Select genomic region:
Overview
7.1
8.1
8.2
8.3
8.4
9.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB944818.1 (Enterococcus faecalis EnGen0359)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | terpene-precursor | 584,219 | 605,100 |

NZ_KB944819.1 (Enterococcus faecalis EnGen0359)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | RRE-containing | 302,252 | 323,355 |
Region 8.2 | cyclic-lactone-autoinducer | 719,988 | 740,716 |
Region 8.3 | RiPP-like | 752,687 | 762,974 | Low | enterocin AS-48 | ribosomal:unmodified
Region 8.4 | RiPP-like,lanthipeptide-class-ii | 825,471 | 853,373 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide

NZ_KB944820.1 (Enterococcus faecalis EnGen0359)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | RiPP-like | 249,663 | 260,706 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | terpene-precursor | 584,219 | 605,100 |
Region 8.1 | RRE-containing | 302,252 | 323,355 |
Region 8.2 | cyclic-lactone-autoinducer | 719,988 | 740,716 |
Region 8.3 | RiPP-like | 752,687 | 762,974 | Low | enterocin AS-48 | ribosomal:unmodified
Region 8.4 | RiPP-like,lanthipeptide-class-ii | 825,471 | 853,373 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide
Region 9.1 | RiPP-like | 249,663 | 260,706 |

No secondary metabolite regions were found in these records:
  NZ_KB944812.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944813.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944814.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944815.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944816.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944817.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944821.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944822.1 (Enterococcus faecalis EnGen0359)
  NZ_KB944823.1 (Enterococcus faecalis EnGen0359)

Compact view
NZ_KB944818.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 584,219 - 605,100 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
WOK_RS09880: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
WOK_RS09915: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
WOK_RS09915: PT_FPPS_like
Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_KB944819.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 302,252 - 323,355 nt. (total: 21,104 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
WOK_RS11890: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.5 |  | 0.44 | ribosomal | microcin C7 | Escherichia coli
BGC0000626.3 |  | 0.40 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.40 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.3 |  | 0.40 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0001660.3 |  | 0.40 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001787.3 |  | 0.39 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000521.3 |  | 0.38 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.5 |  | 0.44 | ribosomal | microcin C7 | Escherichia coli
BGC0000626.3 |  | 0.40 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.40 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.3 |  | 0.40 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0001660.3 |  | 0.40 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001787.3 |  | 0.39 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000521.3 |  | 0.38 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 26.12 out of 26.12
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.70 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78
Confidence: medium
Additional weak hits (4):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.13 out of 26.85
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.90 out of 31.73
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.16 out of 35.63
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (302251...323355)
WOK_RS11845
  RRE type: Pantocin_Microcin_RRE
  Location: 3 - 79
  Score: 32.0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LuxO | Repressor of luminescence
MogR | Repressor of flagellar motility genes

NZ_KB944819.1 - Region 2 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 719,988 - 740,716 nt. (total: 20,729 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii
BGC0001366.5 |  | 0.27 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0002058.3 |  | 0.27 | NRPS, PKS | mutanocyclin | Streptococcus mutans B04Sm5
BGC0002287.2 |  | 0.27 | NRPS | mutanocyclin, leuvalin, tyrvalin | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii
BGC0001366.5 |  | 0.27 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0002058.3 |  | 0.27 | NRPS, PKS | mutanocyclin | Streptococcus mutans B04Sm5
BGC0002287.2 |  | 0.27 | NRPS | mutanocyclin, leuvalin, tyrvalin | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
Additional weak hits (1):
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.68 out of 29.72
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism

NZ_KB944819.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 752,687 - 762,974 nt. (total: 10,288 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.53 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000489.3 |  | 0.46 | ribosomal | enterocin AS-48 | Enterococcus faecalis
BGC0001291.3 |  | 0.46 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0000487.5 |  | 0.44 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000523.3 |  | 0.31 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000557.5 |  | 0.27 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000526.5 |  | 0.26 | ribosomal | macedocin | Streptococcus macedonicus
BGC0001221.5 |  | 0.23 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.53 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000489.3 |  | 0.46 | ribosomal | enterocin AS-48 | Enterococcus faecalis
BGC0001291.3 |  | 0.46 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0000487.5 |  | 0.44 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000523.3 |  | 0.31 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000557.5 |  | 0.27 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000526.5 |  | 0.26 | ribosomal | macedocin | Streptococcus macedonicus
BGC0001221.5 |  | 0.23 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 23.98 out of 25.88
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_KB944819.1 - Region 4 - RiPP-like,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 825,471 - 853,373 nt. (total: 27,903 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
WOK_RS14340: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
WOK_RS14350: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000504.5 |  |  | 0.88 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000618.3 |  |  | 0.48 | ribosomal | enterocin A | Enterococcus faecium DO
BGC0000500.5 |  |  | 0.21 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000509.4 |  |  | 0.19 | ribosomal | epilancin 15x | Staphylococcus epidermidis
BGC0001407.5 |  |  | 0.18 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000516.4 |  |  | 0.18 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000525.5 |  |  | 0.18 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002698.2 |  |  | 0.18 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000623.3 |  |  | 0.17 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  |  | 0.17 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.96 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000618.3 |  | 0.57 | ribosomal | enterocin A | Enterococcus faecium DO
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.50 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000516.4 |  | 0.50 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002698.2 |  | 0.49 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.48 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001210.5 |  | 0.47 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for WOK_RS14350

WOK_RS14355
Leader:
MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS
Core:
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
Core with dehydrations:
G D V Q A E Dhb Dhb P A Cys F Dhb I G L G V G A L F Dha A K F Cys

#### antiSMASH-DB 4.0 matches for WOK_RS14355

100.0%
NZ_AP026721.1 and 35 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide
Lanthipeptides: PO855_RS02215_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
85.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide
Lanthipeptides: BEH_RS02100_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T I G L G V G A L S A C
1
G D V Q A E T T P V C F T I G L G V G A L V S A A G C
27
77.8%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide
Lanthipeptides: IKS_RS03655_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G V G+L S A C
1
G D V Q A E T T P V C F T V G L G V G S L V S A S V C
27
with 108 more sequence matches
Only the first 10 are displayed here.
74.1%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide
Lanthipeptides: IKS_RS03660_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G+G+L S A C
1
G D V Q A E T T P V C F T V G L G I G S L V S A S V C
27
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10230_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P I C G F T I G I G I G A L A S V K W C
28
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10250_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P L C G F T I G I G I G A L V S V K W C
28
70.0%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide
Lanthipeptides: COK11_RS25885_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T I G L G+G A L S A C
1
G D V K P E T T P A C L A G F T I G L G I G A L A S A A G C
30
66.7%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26125_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T+G L G+G A L S A C
1
G D V K P E T T P A C L A G F T V G L G I G A L A S A A G C
30
63.0%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08035_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q E T+P A C T I G+G+G S F C
1
G D V Q P E T S P A C V T I G I G I G I G I S K L F C
27
59.3%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide
Lanthipeptides: OF830_RS26725_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V Q E T T P A C T L G +F S K+C
1
S D V Q P E T T P A C V T-A L T T G I I F S I K W C
26
58.6%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide
Lanthipeptides: OF830_RS26730_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
D V Q E T T P A C F T I G V +F S + C
1
S D V Q P E T T P A C A V A F T I G A T V--I F S V R N C
28
57.1%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11325_lanthipeptide
2
D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
D V Q E T T P C F +G+G+G A+ S A C
2
D V Q P E T T P V C G F F V G V G I G A I I S A T A C
28
55.6%
NZ_JACSPU010000002.1:
Lanthipeptides: H9630_RS06775_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V E T T P A C G L F S K F C
1
S D V A P E T T P A C-V A A F A T G L L F S I K F C
26

#### MIBiG 4.0 matches for WOK_RS14355

27.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
T T P A C F T I G L G V G A L-------F S A K F C
27
T P A + L G+ A+ S A F C
1
T D P A V T G L I L G I V A I Q A G V A V G V S A A F C
28
11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
8
T P A C F T
13
T P C T
8
T P G C K T
13
7.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
9
P A C F T I G
15
P A C T+
38
P A C H T L S
44
WOK_RS14360
Leader:
MENLNVVPSFEELSVEEMEAIQGS
Core:
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
Core with dehydrations:
G D V Q A E Dhb Dhb P V Cys A V A A Dhb A A A Dha Dha A A Cys G W V G G G I F Dhb G V Dhb V V V Dha L K H Cys

#### antiSMASH-DB 4.0 matches for WOK_RS14360

100.0%
NZ_AP026721.1 and 34 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide
Lanthipeptides: PO855_RS02210_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
93.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide
Lanthipeptides: BEH_RS02105_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V S L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V S L K S C
44
90.9%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide
Lanthipeptides: BEH_RS02110_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V+L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V T L K S C
44
with 107 more sequence matches
Only the first 10 are displayed here.
86.4%
NZ_JH791802.1 and 5 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptide NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide
Lanthipeptides: IKS_RS30065_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A S S A A C G W V G G G I T G V T V V++L K C
1
G D V Q A E T T P V C A I A A T T A A S S A A C G W V G G G I A T G V T V V I T L K S C
44
84.1%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26130_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S C G G G I T G V T V V V S L K H C
1
G D V Q A E T T P V C A I A A T A A A S S G I C A A T G G G I A T G V T V V V S L K H C
44
81.8%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide
Lanthipeptides: COK11_RS25880_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S C G G I T G V T V V V S L K C
1
G D V Q A E T T P V C A V A A T A A A S S G V C A A T G A G I A T G V T V V V S L K S C
44
77.3%
NZ_MIFM01000001.1 and 1 other:
NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide
Lanthipeptides: BHL22_RS00425_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V+ S S A A C G W V G G I T G V T V V V+L K C
1
G D V Q A E T T P V C A V S V A T M T S S A A C G W V A G G I A T G V T V V V T L K S C
44
72.7%
NZ_CP062165.1 and 5 others:
NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide
Lanthipeptides: JNUCC31_RS17165_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A V A A T A A S S A C V G G G I G V T+V+++K C
1
G D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
72.7%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11330_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P V C A V A A T A A S S A C V G G G+ G V T V V++L K C
1
A D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G V A V G V T V V L T L K T C
44
70.5%
NZ_KB946334.1 and 1 other:
NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide
Lanthipeptides: UC7_RS10245_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q A E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10240_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q V E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_LN831278.1:
Lanthipeptides: BN1360_RS08835_lanthipeptide
2
D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P+C A V A A T A A S S A C V G G G I G V T+V+++K C
2
D V Q P E T T P I C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
65.9%
NC_014098.1:
Lanthipeptides: BTUS_RS14190_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P+C A A T A S S A A C V G G I G V T+V+++K C
1
G D V Q A E T T P I C Y T A A T V T A S S A A C A G V G A G I V A G V T I V L T I K R C
44
WOK_RS14385
Leader:
MSVVIGA
Core:
D L A G L K L K E I V K S F P E E E G H Q V V D V P T E G Q D F I D V T L S V A K R G K S W Y C H
Core with dehydrations:
D L A G L K L K E I V K Dha F P E E E G H Q V V D V P Dhb E G Q D F I D V Dhb L Dha V A K R G K Dha W Y Cys H

#### antiSMASH-DB 4.0 matches for WOK_RS14385

100.0%
NZ_KB944819.1:
Lanthipeptides: WOK_RS14385_lanthipeptide
1
D L A G L K L K E I V K S F P E E E G H Q V V D V P T E G Q D F I D V T L S V A K R G K S W Y C H
49
D L A G L K L K E I V K S F P E E E G H Q V V D V P T E G Q D F I D V T L S V A K R G K S W Y C H
1
D L A G L K L K E I V K S F P E E E G H Q V V D V P T E G Q D F I D V T L S V A K R G K S W Y C H
49
22.2%
NZ_QKUF01000002.1:
Lanthipeptides: allorf_268360_268587_lanthipeptide
6
K L K E I V K S F P E E E G H Q-V V D V P T E G
29
K L +I V K P E G H P E G
15
K L I K I V K I S P E A S G H N P F F G Y P A E G
39
18.4%
NZ_CP006872.1:
Lanthipeptides: allorf_5538288_5538485_lanthipeptide
29
G Q D F I D V T L S V A K R G K S W Y
47
G D D T V A G K+ Y
12
G D D K T D N T K C V A T C G K N C Y
30
with 5 more sequence matches
14.3%
NZ_AP012322.1 and 1 other:
NZ_CP014241.1 Lanthipeptides: Bang102_RS07925_lanthipeptide
Lanthipeptides: BBAG_RS05705_lanthipeptide
33
I D V T L S V A K R G K S W Y
47
+D V T+S V A S++
16
V D V T V S V A M S V A S Y F
30
14.3%
NZ_CP024848.1:
Lassopeptides: CUC15_RS18285_lassopeptide
4
G L K L K E I V K S F P E E E G H Q V V D
24
G+K + V+ P+ H V V+
3
G I K T P D A V Q P D P D A H D H D V V N
23
14.3%
NZ_CP031010.1 and 2 others:
NZ_JAHKQF010000008.1 Lassopeptides: KO501_RS05760_lassopeptide NZ_JAHKQR010000002.1 Lassopeptides: KO518_RS03645_lassopeptide
Lassopeptides: DS731_RS04595_lassopeptide
10
I V K S F P E E E G H Q V V D V P T E G
29
S P+E+G Q P +G
2
F A G S I P D E Q G G Q T K R N P F Q G
21
14.3%
NZ_MKZS01000001.1:
Lanthipeptides: BJP37_RS12670_lanthipeptide
22
V V D V P T E G Q D F I
33
V V D +G Q F I
18
V V D C G A K G Q T F I
29
10.2%
NZ_MOOT01000057.1:
Lanthipeptides: BK765_RS32535_lanthipeptide
11
V K S F P E E E G H Q V
22
++S F P E+ H++
28
L Q S F P N E K A H R L
39
allorf_0835577_0835699
Leader:
METAHSKIHFVKGLSNSFGK
Core:
N K N K N S M I K F V T A S I N N G C M
Core with dehydrations:
N K N K N Dha M I K F V Dhb A Dha I N N G Cys M

#### antiSMASH-DB 4.0 matches for allorf_0835577_0835699

100.0%
NZ_CP091901.1 and 5 others:
NZ_KB932317.1 Lanthipeptides: allorf_1274501_1274623_lanthipeptide NZ_KB944819.1 Lanthipeptides: allorf_0835577_0835699_lanthipeptide NZ_KB946767.1 Lanthipeptides: allorf_0873518_0873640_lanthipeptide NZ_KB946767.1 Lanthipeptides: allorf_0869748_0869870_lanthipeptide NZ_KZ845881.1 Lanthipeptides: allorf_0859524_0859646_lanthipeptide
Lanthipeptides: allorf_1827294_1827416_lanthipeptide
1
N K N K N S M I K F V T A S I N N G C M
20
N K N K N S M I K F V T A S I N N G C M
1
N K N K N S M I K F V T A S I N N G C M
20
52.8%
NZ_CP015883.1 and 1 other:
NZ_JAASJP010000011.1 Lanthipeptides: allorf_43013_43183_lanthipeptide
Lanthipeptides: allorf_0205278_0205448_lanthipeptide
1
N K N K N S M I K F V T A S I N N G C M
20
N K N K N S I K F V T A S I N N G C M
1
N K N K N S T I K F V T A S I N N G C M
20
allorf_0848268_0848384
Leader:
MLEKIKRDFSRCVKIKVTKILKHHHGG
Core:
I P Y G Y Y T I I C R
Core with dehydrations:
I P Y G Y Y Dhb I I Cys R

#### antiSMASH-DB 4.0 matches for allorf_0848268_0848384

100.0%
NZ_CP091901.1 and 5 others:
NZ_KB932317.1 Lanthipeptides: allorf_1260456_1260572_lanthipeptide NZ_KB932336.1 Lanthipeptides: allorf_1630831_1630947_lanthipeptide NZ_KB944819.1 Lanthipeptides: allorf_0848268_0848384_lanthipeptide NZ_KB946767.1 Lanthipeptides: allorf_0886194_0886310_lanthipeptide NZ_KZ845881.1 Lanthipeptides: allorf_0872228_0872344_lanthipeptide
Lanthipeptides: allorf_1839998_1840114_lanthipeptide
1
I P Y G Y Y T I I C R
11
I P Y G Y Y T I I C R
1
I P Y G Y Y T I I C R
11

#### MIBiG 4.0 matches for allorf_0848268_0848384

14.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
4
G Y Y T I I C R
11
+Y I C R
2
A W Y N I S C R
9
allorf_0848311_0848466
Leader:
MNIRDKIRKINDMILHS
Core:
N K L F S H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
Core with dehydrations:
N K L F Dha H F V A D F I Cys R L L Y N I H R E F L H G D V Dha R F L Dha P

#### antiSMASH-DB 4.0 matches for allorf_0848311_0848466

100.0%
NZ_CP091901.1 and 3 others:
NZ_KB932336.1 Lanthipeptides: allorf_1630874_1631029_lanthipeptide NZ_KB944819.1 Lanthipeptides: allorf_0848311_0848466_lanthipeptide NZ_KZ845881.1 Lanthipeptides: allorf_0872271_0872426_lanthipeptide
Lanthipeptides: allorf_1840041_1840196_lanthipeptide
1
N K L F S H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
34
N K L F S H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
1
N K L F S H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
34
97.1%
NZ_KB932317.1:
Lanthipeptides: allorf_1260374_1260529_lanthipeptide
1
N K L F S H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
34
N K L F H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
1
N K L F G H F V A D F I C R L L Y N I H R E F L H G D V S R F L S P
34
20.6%
NZ_JAFLVY010000007.1:
Lanthipeptides: allorf_043836_043934_lanthipeptide
4
F S H F V A D F I C R L
15
F H F D F+C L
2
F F H F F G D F M C S L
13
with 1 more sequence matches
14.7%
NZ_CP026121.1 and 1 other:
NZ_CP075896.1 Lassopeptides: KJK29_RS31770_lassopeptide
Lassopeptides: C1703_RS06295_lassopeptide
1
N K L F S H F V A D F
11
N +F H+ D F
7
N D I F G H Y S G D F
17

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.20 out of 29.25
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.88 out of 28.14
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.73 out of 32.93
Confidence: medium
Additional weak hits (3):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.47 out of 29.38
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.06 out of 19.52
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 15.93 out of 20.47
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

WOK_RS14355 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 2630.3 Da
  Molecular weight: 2632.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2650.0 Da N = 1
    2668.0 Da N = 2
WOK_RS14360 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 4017.0 Da
  Molecular weight: 4019.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4037.6 Da N = 1
    4055.6 Da N = 2
    4073.6 Da N = 3
    4091.6 Da N = 4
    4109.6 Da N = 5
WOK_RS14385 - Class II
  Cleavage pHMM score: -5.00
  RODEO score: 0
  Monoisotopic mass: 5406.8 Da
  Molecular weight: 5410.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5428.1 Da N = 1
    5446.1 Da N = 2
    5464.1 Da N = 3
    5482.1 Da N = 4
allorf_0835577_0835699 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 2159.1 Da
  Molecular weight: 2160.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2178.5 Da N = 1
    2196.6 Da N = 2
allorf_0848268_0848384 - Class II
  Cleavage pHMM score: -3.60
  RODEO score: 0
  Monoisotopic mass: 1342.7 Da
  Molecular weight: 1343.6 Da
  Number of bridges: 1
allorf_0848311_0848466 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4036.1 Da
  Molecular weight: 4038.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4056.6 Da N = 1
    4074.7 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
PerR | Peroxide regulator
SypG | Regulator of biofilm formation and host colonization

NZ_KB944820.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 249,663 - 260,706 nt. (total: 11,044 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000818.5 |  | 0.22 | NRPS | notoamide A | Aspergillus versicolor

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000818.5 |  | 0.22 | NRPS | notoamide A | Aspergillus versicolor

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production