LOCUS       NZ_KB944666            20729 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Enterococcus faecalis EnGen0336 strain T5 acAro-supercont1.1, whole
            genome shotgun sequence.
ACCESSION   NZ_KB944666
VERSION     NZ_KB944666.1
KEYWORDS    WGS; RefSeq.
SOURCE      Enterococcus faecalis EnGen0336
  ORGANISM  Enterococcus faecalis EnGen0336
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Enterococcaceae; Enterococcus.
REFERENCE   1  (bases 1 to 2806553)
  AUTHORS   Earl,A.M., Gilmore,M.S., Lebreton,F., Walker,B., Young,S.K.,
            Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B., Abouelleil,A.,
            Alvarado,L., Arachchi,H.M., Berlin,A.M., Chapman,S.B., Dewar,J.,
            Goldberg,J., Griggs,A., Gujja,S., Hansen,M., Howarth,C.,
            Imamovic,A., Larimer,J., McCowan,C., Murphy,C., Neiman,D.,
            Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T., Sisk,P.,
            Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Enterococcus faecalis T5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2806553)
  AUTHORS   Earl,A.M., Gilmore,M.S., Lebreton,F., Walker,B., Young,S.K.,
            Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B., Abouelleil,A.,
            Alvarado,L., Arachchi,H.M., Berlin,A.M., Chapman,S.B., Dewar,J.,
            Goldberg,J., Griggs,A., Gujja,S., Hansen,M., Howarth,C.,
            Imamovic,A., Larimer,J., McCowan,C., Murphy,C., Neiman,D.,
            Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T., Sisk,P.,
            Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2013) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R42411
            Assembly Name                     :: Ente_faec_T5_V1
            Genome Coverage                   :: 289.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000393015.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 13:32:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,757
            CDSs (total)                      :: 2,690
            Genes (coding)                    :: 2,666
            CDSs (with protein)               :: 2,666
            Genes (RNA)                       :: 67
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 8 of 24
            Pseudo Genes (incomplete)         :: 14 of 24
            Pseudo Genes (internal stop)      :: 4 of 24
            Pseudo Genes (multiple problems)  :: 2 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:17:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1875594
            Orig. end                         :: 1896323
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB944666.1.
            Please be aware that the annotation is done automatically with
            little or no manual curation.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20729
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="4"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20729
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20729
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10729](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10729)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    107..122
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: strong, score: 28.99"
                     /tool="antismash"
     misc_feature    578..592
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     gene            complement(1997..3385)
                     /db_xref="GeneID:60894102"
                     /locus_tag="WMS_RS12195"
                     /old_locus_tag="WMS_01808"
     CDS             complement(1997..3385)
                     /codon_start=1
                     /db_xref="GeneID:60894102"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010712556.1"
                     /locus_tag="WMS_RS12195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01808"
                     /product="MFS transporter"
                     /protein_id="WP_010712556.1"
                     /transl_table=11
                     /translation="MIDRKKVILYTCCMSLFVVTMDVTVVNVALPSIQSDFHTNLSTLQ
                     WVTDGYTLMVASLLLLSGSTADRIGRKRVLQLGLACFGLASFLCGISQTPGQLIAFRML
                     QGIGGSMLNPVAMSIITQVFTEKLERAKAIGLWGSVTGISLGMGPIIGGLIVSYFSWRY
                     VFFVNVPIIAAAIILTQKFVPESKVEKTAKNDFVGQALMILFLFSSIYSIIGLPRKGLF
                     APDILSTGIIGCLAIVIFFIYEYNIDNPLINPRFFLSIPFTSASFLAIFGFIIYNGYLF
                     LNTLYLQEMRGFSPLEAGLSTIPLAFVSFLVAPRAGEMVGRIGTKRPIMLCGISMLAVS
                     FLQLFVTKTTPMIILFVIYIFLGIGFGMLNSPITITAIEGMPLSQSGTAAAIAVTCKQI
                     GNSLGVALPSLLITKPITSSLTRTPFTNVWLLFGCCAIAIIFLSYLSNSPLAKKSLRRV
                     RFYF"
     gene            complement(3767..4621)
                     /db_xref="GeneID:60894103"
                     /locus_tag="WMS_RS12200"
                     /old_locus_tag="WMS_01809"
     CDS             complement(3767..4621)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60894103"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010821679.1"
                     /locus_tag="WMS_RS12200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01809"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_002357233.1"
                     /transl_table=11
                     /translation="MTIEKLEYFYTIAKYNSISKAASELHVSKSTLSASLKDLESELGH
                     LLFDRNGNSLTLNSYGDKIVQSVYIILNEAKKMKLNLHEMIENPVMRLGFGNTSLMYKV
                     TENEDQLNRFWECYHGSSFELLNKLENHELDFVITSADVNSPVLKKEQLIELKMYLCVS
                     REIKQEIEEEGFTCLTNYPFLFLPHHLDHLEATKSVLEMLQLTSPLVCCYDTLMLTRLI
                     EKSKGVYAVISLRKEQLQEIDSKLFFLPIERKQKFYLYRNVSSSVFVQPGQIKATLQKL
                     LET"
     gene            5013..5843
                     /db_xref="GeneID:60894104"
                     /locus_tag="WMS_RS12205"
                     /old_locus_tag="WMS_01810"
     CDS             5013..5843
                     /codon_start=1
                     /db_xref="GeneID:60894104"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002397393.1"
                     /locus_tag="WMS_RS12205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01810"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_010819437.1"
                     /transl_table=11
                     /translation="MKINYLGTGAAERIPGIFCNCKLCKYAREKKGREIRTQTQLIIDD
                     VLLIDFPGDSYLHLLQYDLCFADFNSLLISHWHSDHFYGEDLAYRMSGYALDIPNRLTV
                     YGNEAVKTFYQRAFDLEGRQDDTRLHYQVIQPYKCFSIANYTIYPLPAQHGNFSEDCFI
                     FVIDDGKDAFLSTHDTGYFTSEMFEYLEKSHLLLNIVSLDCTSQTNETGNSHMNWEENL
                     KLIAELKERKLVTDKTIYVANHFSHNGGLSYAEMAALSQKHEIITSYDGLEILT"
     gene            complement(5991..6845)
                     /db_xref="GeneID:60894105"
                     /gene="sprE"
                     /locus_tag="WMS_RS12210"
                     /old_locus_tag="WMS_01811"
     CDS             complement(5991..6845)
                     /codon_start=1
                     /db_xref="GeneID:60894105"
                     /gene="sprE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002364098.1"
                     /locus_tag="WMS_RS12210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01811"
                     /product="serine proteinase SprE"
                     /protein_id="WP_010819438.1"
                     /transl_table=11
                     /translation="MKKFSIRKISAGFLFLILVTLIAGFSLSANAEEYIVPAESHSRQK
                     RSLLDPEDRRQEVADTTEAPFASIGRIISPASKPGYISLGTGFVVGTNTIVTNNHVAES
                     FKNAKVLNPNAKDDAWFYPGRDGSATPFGKFKVIDVAFSPNADIAVVTVGKQNDRPDGP
                     DLGEILTPFVLKKFESSDTHVTISGYPGEKNHTQWSHENDLFTSNFTDLENPLLFYDID
                     TTGGQSGSPIYNDQFEVVGVHSNGGIKQTGNHGQRLNEVNYNFIVNRVNEEENKRLSAV
                     PAA"
     gene            complement(6894..8426)
                     /db_xref="GeneID:60894106"
                     /gene="gelE"
                     /locus_tag="WMS_RS12215"
                     /old_locus_tag="WMS_01812"
     CDS             complement(6894..8426)
                     /EC_number="3.4.24.30"
                     /codon_start=1
                     /db_xref="GeneID:60894106"
                     /gene="gelE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002369251.1"
                     /locus_tag="WMS_RS12215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01812"
                     /product="M4 family metallopeptidase coccolysin"
                     /protein_id="WP_080113944.1"
                     /transl_table=11
                     /translation="MMKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLS
                     KLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDRNGAVTSV
                     TGNPVDQVVKIQSVDAIGEEGVKKIIASDNPETKDIVFLAIDKRVNNEGQLFYKVRVTS
                     SPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVTFNVPVEKSNTGIALHG
                     TDNTGVYHAVVDGKNNYSIIQAPSLATLNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRG
                     MPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAG
                     LEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMA
                     QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQ
                     FSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVNQPSESVLVNE"
     gene            complement(8661..10004)
                     /db_xref="GeneID:60894107"
                     /gene="fsrC"
                     /locus_tag="WMS_RS12220"
                     /old_locus_tag="WMS_01813"
     CDS             complement(8661..10004)
                     /codon_start=1
                     /db_xref="GeneID:60894107"
                     /gene="fsrC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402207.1"
                     /locus_tag="WMS_RS12220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01813"
                     /product="sensor histidine kinase FsrC"
                     /protein_id="WP_010717630.1"
                     /transl_table=11
                     /translation="MILSLLATNVLLVSSFIVFVFLRVTLIKIECKIPLLSLLIVINLC
                     SFAALMLGYSWLIYALTVVIFTGFLLIHKKRFSIFKAIFLSVFTLLMVSFINYTEQTIL
                     SVFFQQIYQNKLLWIASNVLLLLINIWIALKIPNSVFLRLNRVLENSRIFFGCLLLLLI
                     LLLLFVFLISPEISPDFMRGFVTVNSSKLELLISVGLFLILIGLVIEAYLEEQRINTQL
                     LNNLTIYTEKIESINEELAMFRHDYKNLLYSLQIAISYEDILEIKRIYEETIAPTKKII
                     DNEEFELMKLNRLKNMELKALISMKINTAKQAKLKVIVDVPEVFILDTSIDLVVVIRLL
                     AILLDNAIENSAKSELKMFAISIFNKNETQEFVITNSVQAEFDFKIMKKTKFSSKSNPE
                     EHGWGLLYVKEIVDFSDQFDLQTSFNEGSVTQHLIIEKNHNSKKVVNE"
     gene            complement(10001..10729)
                     /db_xref="GeneID:60894108"
                     /locus_tag="WMS_RS12225"
                     /old_locus_tag="WMS_01814"
     CDS             complement(10001..10729)
                     /codon_start=1
                     /db_xref="GeneID:60894108"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016634271.1"
                     /locus_tag="WMS_RS12225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01814"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_002377181.1"
                     /sec_met_domain="AgrB (E-value: 1.1e-31, bitscore: 106.9,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIDWILKNIMDMDQEDQSGKTQWTKYYLTVYFSGLFNFLMILIL
                     SVLFGTLSETFIVYVVLIFLRPVAGGWHAKTKWLCRLESIVIYVAIPFVLKNSSVSLPF
                     IYKILLICLLVVLFYWYAPQGTAIEPVQPSDLNVLKKQSLIRVCLLILCSLFVKEKIAS
                     VILYGLVIQGLMILPVTKNLIEGSVFMKFGKKIIKNVIEKRVAKVSDGVGTKPRLNQNS
                     PNIFGQWMGQTEKPKKNIEK"
     gene            complement(10818..11549)
                     /db_xref="GeneID:60894109"
                     /gene="fsrA"
                     /locus_tag="WMS_RS12230"
                     /old_locus_tag="WMS_01815"
     CDS             complement(10818..11549)
                     /codon_start=1
                     /db_xref="GeneID:60894109"
                     /gene="fsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109506.1"
                     /locus_tag="WMS_RS12230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01815"
                     /product="response regulator FsrA"
                     /protein_id="WP_078126945.1"
                     /transl_table=11
                     /translation="MAIYILEDQIIQAKALEALLTNILHSRNIYNETIHLFSRSDELLQ
                     VAHQDAQLNIFFLDIQMNNHIQAGFEVAKEIRKTDSESLIVFISTHTELVLTSYKYMVS
                     ALQFIQKNVDFLDFQKEVETCVDAYIQQKENIKTKSEYIIINLKASSIKMDINDIYFFQ
                     TEYDHRVSMVGKNFKREFYGTLSKIEQLHPDLIRVHQSIIINKKYASKLNYKTHLLTMR
                     DGTEVPVSRRYYTQVKALFLT"
     misc_feature    11661..11676
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            complement(11968..13959)
                     /db_xref="GeneID:60894110"
                     /locus_tag="WMS_RS12235"
                     /old_locus_tag="WMS_01816"
     CDS             complement(11968..13959)
                     /codon_start=1
                     /db_xref="GeneID:60894110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401391.1"
                     /locus_tag="WMS_RS12235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01816"
                     /product="amidase domain-containing protein"
                     /protein_id="WP_010819440.1"
                     /transl_table=11
                     /translation="MKRKKIKNQLLVLTSILVLLSLEVAPVVTLAAELPSSSLQTALSS
                     ETTITSEEKVIETTETTETTETTVATSTTSTSSSSSESNSSTDTTTESTSHSTTETTTT
                     NTSSETKKEPTEPTVSSEITQPIEQSQPPQVQPPQVPVTKQEPEEPIQVPEATNNVVEE
                     NQAVSLNPSLKVDEIASSNLKGYELPLLSSFGEKKRAVVVAEALRHIGKTKKEFNLTEQ
                     ALTSSFLAQKIYQQLFKIDIGSTPQEQMTFGKVRSIEEAEPGDLIFWQTAEGKTLQNGV
                     YLGQGKYLIAAAEADSKEKPEVIAQLENIYTAKQQPDSKEEKRLVVTNPFKEFILTEYG
                     KEVLATYGASFEMLKSEQTTAFIKKIGETARELGEKYDVFASVMIAQAILESGSGESQL
                     AKEPYYNLFGVKGSFQGNSVSFSTKEADQRGQLYTISAGFRDYGGYNDSLQDYVQLLRQ
                     GIDGNQDFYKPAWRSEAKNYLQATRFLTGKYATDKQYDNKLNSLIAVYNLTQFDLPKTA
                     DGLIIQSKNELSEAEQQQMHFPVYDGINYNRSGSYPVGQCTWYVYNRFKQLGTSVDEFM
                     GNGSDWGRKGRALGYQVSSLPKAGRAISFQPGVAGADNQYGHVAFVEAVTSDGIIISES
                     NVINDQTISYRVLPNAIAYSSGVTYIGA"
     gene            complement(14041..19668)
                     /db_xref="GeneID:60894111"
                     /locus_tag="WMS_RS12240"
                     /old_locus_tag="WMS_01817"
     CDS             complement(14041..19668)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60894111"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016633936.1"
                     /locus_tag="WMS_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01817"
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="WP_025189858.1"
                     /transl_table=11
                     /translation="MGSNFKEEKMNKEYQGKKIYGKKHWLTFLLVSSSVLAFHLFVTMD
                     SQVVDAQEQTAKEEVADSATSVGAIVSIEKAEKNFVITYASGKKAQISILNDHLFRYHL
                     DPTGKFEEYPTPNDPKHVAKITAKTMADYGTQAFEQTNVTDSGNQFILENNGLKIMFEK
                     ESALIKVLDKKKDQVILEETAPLSFKNDKATQTLKQSSQENYFGGGTQNGRFTHKGTAI
                     QIVNTNNWVDGGVASPNPFYWSTAGYGVVRNTWKPGNYDFGSHDPQTTTTTHEGTDFDA
                     FYFFNNSSAGILKDYYELTGKPALMPEYGFYEAHLNAYNRDYWVKVAEGTAGAVKFEDG
                     NFYKEYQPGDLGNLNGTLESLNGEKENYQFSARAVIDRYKKNDMPLGWFLPNDGYGAGY
                     GQTDSLDGDVQNLKEFTEYAQANGVEVGLWTQSNLHPADPKNPKKGERDIAKEVSVAGV
                     KALKTDVAWVGYGYSFGLNGVEDAANVFVKETDGAVRPMIVSLDGWAGTQRHAGIWTGD
                     QTGGQWEYIRFHIPTYIGTSLSGQPNVGSDMDGIFGGKNKEVNIRDFQWKTFTPVQLNM
                     DGWGSNPKTPFAFDQEATDLNRAYLKLKSMMMPYNYSIAKESVDGLPMVRAMALEFPNE
                     GTAYTKDSQYQYMWGPNLLVAPIYNGNQDEAGNSIRDGIYLPDEKQVWVDLFTGEKYQG
                     GRVLNGVKTPLWKVPVFVKDGSIIPMTNPNNNPKEIQRDQRSFLIYPNGATSFNMYEDD
                     GISTSYEAGQSATTKINSQGPKSNEKGDLTVTIEPTKGSYSGFVDERSTTLDLLASEAP
                     ESVTAMVGGTEVTLKQAANKEEFLAGTNLYYFDKEFQVNQYLSEASGEKLNQSALSVKL
                     AKQSVTAKDVQITVKGFINKGTVDGGNTTVDDQLTIPANVAINEEKTTPSSLTLQWDQV
                     TEATSYEVERDGTVFGNIQTNTATFDGFSFLSEHTFRVRAVGKNGVSEWSEPIKGKTQD
                     DPYKETINQVKATSNLPEQPGAELKKLTDKDLSTGWHTNWSTGIANPSDGNFLSLKFDL
                     GAEYQMDKIEYLPRDNAGNGNILQLQYRTSKDGANWTEFSEPINWKQDALTKTIETKDQ
                     AYRFVEMKVLKSVGNFGSGREMLFYKQPGTEGILHGDITNDGTIDENDAMSYRNYTGLE
                     SVDSDFNGYVEKGDLNKNGVIDAYDISYVLRQLDGGIEIPDVEEIAGGLSLAVVNENGK
                     DTYLPGDTLTFTLKGQDLKNINALSTKMSFDSSKFELVGQPATTNNTKQMENYSKYRKH
                     SNDVENLYLVLSNQGNKQLLNGSMDLVTFKVKVKETTRVKRATTVEQPLQFDMSQGLLV
                     GQGFQQATLSDFSVTVKPTELVDKELLQALITLNQARVEKEYTPETWAIFKPVLDEAVA
                     VLANEQATQTDVSAAVENLKKAVEQLEKMPDVANKADLEKAIQEGLTKKPSDGQEFTEE
                     TKKVLEESLAAAQKVFAQEKVTQEEIDQATKTLREAIAQLKEQPVAVDKETLKEKIAQA
                     RGRKPEEGYQFTKETEKQLQEAIQAAEAIVAKETATKEEVSEALNALETAMAQLKEVPL
                     VNKDQLQEVVKRAQQVTPSEGHQFTASSLQDLQKALLAAKNTLENPAANQKMIEEAVAE
                     LTSAIDGLQEEALVTDKKALEAMIAKAKAIKPSAGKEFTSESKARLTEAIDQAEGILAD
                     KNARQEQIDTAEKNVKTALDSLEEQVLQADKTKLRELLQKAETLKPKAGKQFTKASQEA
                     LAEAIKQAKALVEDPSATQEAVDKCLSILAQAIEAMAEEPISSNSTGNNRNHGTVSGTG
                     SVTSPGKGTAAGGTTTKTTTSGTLPKANEVVSPIWSISGFLLIVSIGLGKLFFKNKKDQ
                     N"
     gene            complement(20173..20568)
                     /db_xref="GeneID:60894112"
                     /locus_tag="WMS_RS12245"
                     /old_locus_tag="WMS_01818"
     CDS             complement(20173..20568)
                     /codon_start=1
                     /db_xref="GeneID:60894112"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002407764.1"
                     /locus_tag="WMS_RS12245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_01818"
                     /product="hypothetical protein"
                     /protein_id="WP_002361986.1"
                     /transl_table=11
                     /translation="MDGMFANLTLRERRLLKQAQVGATISFILLFVPILTISLLHTSDL
                     LAKWLGIVGVIMVLPLLYFAWQILKIAYKDQKDNPTPPLWVPKVYGIGLSINPYHRFGK
                     LIFILLAVLIVGIIISLLFTPASQINH"
     misc_feature    complement(20715..20729)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.5"
                     /tool="antismash"
ORIGIN
        1 ttttcaaaag ccacatcata gttgtagtcc tttggttgca cttcttggaa tccttgtggt
       61 ttataaaaac gtaaaaggtt ttcctgattt aatttgtcag ataaacttaa cgattttttc
      121 acccaatcgt tatctttcgt gacttctgct tttaaatctg ctggaacttg gtctaatttt
      181 tttccttgat tattgtagat ttccccacct agataagaaa attgaggcgt tacaaaatcg
      241 ccatttctaa aaggaaccac ttgtttatat tgaggagata aaaggtccgt gccaaaatgg
      301 atataatttt tatcatcgac acctaaaaga tggtacagtg tcggtaaaac gtcaatttcc
      361 ccaccatatt cgtgcatgat tttcccttgc gtatagcctg gcatgtaaaa catcaaaggt
      421 actctttgca attgcgcatt gtcatagttt gtccacgttt ttggatcgcg gttgaaggct
      481 ttacacaagt ccttgttgtt cgcatctgaa ataccgaagt ggtcaccata aataacaaaa
      541 atagaatgat tgtataaact tgttgtttgc aagtaatgga aaaattgttc tagcgattga
      601 tccaaatagt gcgctgttcg aacataatca tccacaatcg aattgcctgt gttcaattta
      661 ggaaacggga agttttggtc atccgtataa taaggggtat gattggtcac agttaaaaac
      721 ttcgcataga atggctgctg taaatgctca agctcactag ctgattcacg caacaattgt
      781 ttatctaaaa taccgtaacc tagcattttg tcatcttttg aaaaatatga ccgatcaaaa
      841 aagtattgat aacctaagtt tttatacaca tggtcccgat tccaaaaact ccccacattc
      901 ccatggaaaa cagcggttgt atagcctttt tgtcctaaaa cagcgggagc cgcttcgaaa
      961 gtattgtctg atcctaattg tgtaaaaaga gagccttgcg gtaacccgaa tgttcctgtt
     1021 tccaacatgt tctccgcatc actcgttttt ccttgcccta cttcatgaaa gaaattatca
     1081 aaactgattg tcgctttgtt ttgatagagc tgatttaaaa acggtgtaac ctcttggcct
     1141 tggactttca tattaatcaa aaattgttga aaactttcta aatgaatcac aaatacattt
     1201 tttcctttgg caatcccggc atactgcgga ttaagcggta aattgttttg cttggtaaat
     1261 ttcatgattt caggtaattc gtttgaacta gcttctgctc ttacctcatt tgacatggct
     1321 gttttgacac catcgatggc tgtgaatgca tccaagccaa gatattttac aatataatta
     1381 cgatcgaaaa ttctttgaag caattgagga cgatcggttt cgcttaaaaa taagttaacc
     1441 gaaaagagca agacacttaa acaactaatt gagatcgcca atcttctgtt gataggttta
     1501 gtcataaaga cttgatgatt ccgtcgctgt ttaaaagagt aaaataccaa aacgagcagc
     1561 actaaagtat ctagccaata aaagacatcg tggaccctca ttaaggcaag taaatcacca
     1621 gaaattcctt ctgaaacttt tgaaaagcca aaaacagatt ggatggtaat aaagtcagtg
     1681 aattcacgat aaaaaataat attcaaatat aaaattaatg tatttaaaac atttaaaaga
     1741 gttaagctaa gcataaatgt tttatgcttt ttaaaataca aactaaaacc aaataataac
     1801 agcgtagtag caactggatt gaaccataaa atttctcgct ggagactgcc cttaacgccc
     1861 aatgagaaat ctaggtaata cgccagaatc gtttttgccc aaaagagtaa cacaaaaaat
     1921 aaaaagagtc ctaatcggtt atttattttt ttcatctaag tttgtcttcc tttcccttca
     1981 aaaaaatctt gatttgttaa aaataaaacc taactctgcg caatgacttt ttcgctagcg
     2041 gagaattgga taaataactt aaaaagataa tcgcaatggc gcaacatcca aataaaagcc
     2101 atacgtttgt aaaaggtgtt cgagtaagcg aactagtaat aggctttgta attaaaagac
     2161 ttggtagcgc aacacctaaa gaattgccaa tttgcttaca tgtcaccgca atggctgctg
     2221 ccgttcctga ctgagaaagt ggcattcctt caatcgctgt aatggtaatc ggtgaattta
     2281 acatcccaaa cccaatgcct aaaaagatat aaataacaaa taaaataatc ataggcgttg
     2341 ttttagttac aaataattgt aaaaagctaa cagccaacat tgaaatacca caaagcataa
     2401 taggacgttt cgtccctatt ctccctacca tttcgccggc tctcggtgca acaagaaaac
     2461 taacaaaagc caaaggaatg gttgataagc cagcttccaa cgggctgaag cctctcatct
     2521 cttgcaaata tagcgtgttt aaaaataaat agccgttata tatgataaag ccaaaaatag
     2581 ctaaaaaaga agccgatgta aatggaatag ataaaaagaa acgcgggttg attaacggat
     2641 tgtcaatgtt atattcataa ataaagaaaa tgacaatggc taaacagccg attatcccag
     2701 tacttaaaat atctggcgcg aaaagccctt ttctaggtag tccgataatg gaatagatag
     2761 aactaaatag aaaaagaatc atcaatgctt gaccaacaaa atcatttttc gccgttttct
     2821 ctacttttga ctcaggtaca aacttttgtg taaggataat tgccgcagca atgatcggta
     2881 catttacaaa aaagacatac cgccagctaa aataagaaac aattagtccg ccaataatcg
     2941 ggcccatgcc taaggaaatc cctgtaacag agccccacaa gccaattgct ttcgctcttt
     3001 ctaacttttc ggtaaatacc tgtgtaataa tagacattgc taccggattt aacatagaac
     3061 caccaatccc ttgcaacatg cgaaacgcga tcaattgccc tggggtttgc gaaatcccac
     3121 ataggaaaga cgctaaacca aaacaggcta agcccaattg aaggactcgt ttacggccaa
     3181 ttcgatctgc tgtagaccca gacaacaata ataaggatgc taccattaaa gtgtagccat
     3241 ctgttaccca ctgtaatgta gacagattcg tgtgaaaatc actttgaatg gatggtaacg
     3301 ccacattgac aaccgtaaca tccatggtca ctacaaacaa actcatgcaa caagtataca
     3361 aaataacttt ttttctatcg atcataaaaa cagtcctttc tagcaactac ataaaacagg
     3421 aaaagcaaca atgacactta aacttctaac gacacggtta tcgcaagtac tcacgtatca
     3481 acagttcttt atattccttg ccatttagtt attttatact taaaaaagta aatctttaga
     3541 tagccaaact atacaccaga acccttttaa attgaaccgt aatagatacg atttatcgat
     3601 tcttaagtta ttaaataatt gaacattccg ttcagaaata tcgaacagtc ccataattga
     3661 gtatctcttt taaacaatga acatcaaaaa taaccttatc cgcagcagaa gtaaatctaa
     3721 gcgaataaag ctatttttgg taactattcc aaagtaattt taatggctaa gtctctagca
     3781 acttttgtaa agttgccttg atttgaccag gttggacaaa aaccgaactg gaaacatttc
     3841 ggtataaata aaatttttgt tttcgttcaa tcggtaaaaa gaagagttta gaatcaattt
     3901 cctgcagttg ttctttccga agagagatta ccgcataaac tcctttactt ttttcaatga
     3961 gacgagtaag catcaacgta tcgtagcaac aaacaagcgg acttgttaat tgcaacattt
     4021 ctagcacact cttggtagct tctaaatgat ctaagtgatg cggcaaaaat agaaatggat
     4081 agttggtcaa acaggtgaag ccttcttcct caatttcttg tttaatttct cttgaaacac
     4141 aaagatacat ttttagttca attaattgtt ctttctttaa aactggacta ttcacatctg
     4201 cagaagtaat cacaaaatcc aactcatgat tctccaattt attcaataac tcaaacgatg
     4261 aaccatggta acattcccaa aaacgattca gttgatcctc attttctgtc actttataca
     4321 tcaaggacgt atttccaaaa cctaaacgca tcactggatt ctcaatcatt tcatgcaaat
     4381 taagtttcat tttcttagcc tcgtttaaaa tgatatatac agattggacg attttatcac
     4441 cataggaatt taacgtcaaa gaattaccgt tacggtcaaa aagtaaatgg cccaattcac
     4501 tttccaaatc ttttaatgac gcacttaagg ttgatttact aacatggagt tcagaggctg
     4561 ctttggaaat actattatat tttgcaatgg tataaaaata ttctaatttt tcaatagtca
     4621 tcttttgtca tcccttttat tcaaattcat ttccccacgc aacctgttca aaacacgcct
     4681 cactctttat caatagcgta gttatttttg ctctaataag ctatgtccat cttgttattt
     4741 ttctataact aatagcagat ggatatgaaa gtgcctttgg taaaactttt tctcggaaat
     4801 agcatgaaca ttcacaacaa attcagctta ttaaaaaagg cgtctagctt tttctatttt
     4861 acgcatattt acttaagaaa ttccatttca attcttctct aaaaaaggta agatggacac
     4921 aacaaatgtt tcagtttcca tgcccattta ctttaaggtt cagcgttatc tactaagtat
     4981 gaagaatgtc aaagaaaggt taggtactcc caatgaaaat caactattta ggtacgggtg
     5041 cagcagaacg gattccagga attttttgta attgtaaatt atgtaagtac gctcgagaga
     5101 aaaaaggacg agaaattcgt acacaaactc aattaattat tgatgatgtc ctgctgattg
     5161 attttccagg agattcttat ttacacttgt tgcagtatga cttgtgtttt gcagacttta
     5221 actctttact aatctctcat tggcattccg atcattttta cggcgaggat ttggcttatc
     5281 gaatgtctgg ttatgcatta gatattccca atcgtttaac tgtttacgga aatgaagcag
     5341 ttaagacgtt ttatcagcgc gcctttgatt tagaaggtcg tcaagacgat acccgattac
     5401 attatcaggt tattcagccc tacaaatgtt ttagtattgc gaactatacg atttatcccc
     5461 ttcctgcaca acatggaaat ttcagtgaag attgttttat tttcgttatt gacgatggta
     5521 aagatgcttt tttatccacc catgatacag gttactttac gtcagaaatg tttgaatatc
     5581 ttgaaaagag ccacttactt cttaatattg tttctttaga ttgtactagt caaacaaacg
     5641 aaactggcaa tagtcatatg aattgggaag aaaatttaaa attaattgca gaattaaaag
     5701 aaagaaaact cgtcacagat aaaacgattt acgttgccaa ccatttttct cacaatggtg
     5761 gcttgtctta tgcggagatg gcggctttat ctcaaaagca tgaaatcatt acgagttatg
     5821 atgggttaga aatactaact taatcggatt atttgccttc ttttcagcac tattatatgc
     5881 ttttaaccga taattacaag gtacttttat cgtaacttac actatcttaa aaaacaaaaa
     5941 tactcgagat ttcccgtgat tctggaaatt ccgagtattt ttatggttct ttacgctgct
     6001 ggcacagcgg ataaacgttt attttcttct tcattcactc gattaacaat aaagttataa
     6061 ttcacttcat ttagtctttg accatgattt cctgtttgct taatgccacc attggaatga
     6121 acaccaacta cttcaaactg atcattatag attggtgaac cagattgacc accggttgta
     6181 tcgatatcat aaaatagtaa tggattttct aagtctgtaa agttagatgt aaacaaatca
     6241 ttttcatgag accattgtgt gtggtttttc tcacctggat agcctgatat tgtgacatgg
     6301 gtatctgaag attcaaactt tttcaaaaca aatggcgtta aaatttctcc caaatctggg
     6361 ccatctggac gatcgttttg tttgccgaca gtcactaccg caatatccgc attcggggaa
     6421 aaagctacat caatcacttt gaatttgcca aatggtgtcg cactgccatc tcgacctgga
     6481 taaaaccaag catcatcttt ggcattcgga tttaatactt tggcattctt aaaactttca
     6541 gccacatgat tattggtgac aattgtatta gttccaacaa caaagcctgt tcctaaagaa
     6601 atatagcctg gtttactggc aggggaaatg attcttccga ttgacgcaaa aggcgcttcg
     6661 gttgtatctg ccacttcttg tcttctgtct tcagggtcca gtaacgatct tttttgtcgt
     6721 gaatgacttt cggcaggaac gatatactct tctgcatttg cagacaagct aaaaccggct
     6781 atcaaagtta ctaaaatcag aaacaaaaaa ccagcactaa tttttcgtat ggagaacttt
     6841 ttcataagat tatgccactc cttatccatt tttatttaat tggggaattt ttttcattca
     6901 ttgaccagaa cagattcact tggttggttt acttgaatat cctctttagc tccgattcca
     6961 gcagagttaa aggctgctga caccactgaa gctgcttcat cgccatattg aacttttgca
     7021 gcagcaagca tcgcatcacg agcatcactg aattgtgctt taggtgttaa gtaatttact
     7081 aacgagctgt agaaaatagt ctgtgctttt tcaatgccta agttctggat aatggtgtaa
     7141 ccaatccgat taataattcc actattataa tgaacaccgc cttgatcata ataaggcgtt
     7201 cctttatacc gtgctcgatc gtcgtattga gccatggttt ctggttgtcc gtgtttactt
     7261 ggcgtttgta aatttcgaat acctgttttt cggtcaacac tctgagtatc cgcaccaatt
     7321 tctggattag atgcacccga aataatataa cccatcaaat cagaataaga ttcattcaac
     7381 gcacctgatt gtcctaaata ttctaaaccg gcagtatgtt ccgtcacacc atgtgtcatt
     7441 tcatgaccaa ctacatctaa agaggaagca tacgtttttc ctgttggtgt acttgtttca
     7501 ccataacgca ttgcttttcc atcccaaaaa gcattgtcat aagcatctgg atgttgttca
     7561 tcaacaactg acaagatggg catccctcga tcatcaatac tgtgtcgttg gaaatgatct
     7621 tcataatatg ttttcacaaa ttttccatgc gtataggcgt caacagcatt ctgatttaat
     7681 gtcgctagtg atggcgcttg aataatagaa taattatttt tgccatcaac tactgcatgg
     7741 taaacccctg tgttatccgt tccgtgtaaa gcaattcccg tattgctttt ttcaactggt
     7801 acattaaacg ttacttgaaa agagtttttt aacgttactt cactaccgac atgttccgtt
     7861 aaatcttgtt tttccataat tgttccatct gtagcgttca ctttataaac caatgatacg
     7921 gggtcaccag ttggtgaaga agttactctg actttataaa ataattgccc ttcattattt
     7981 acacgtttgt caatagctaa aaagacaata tctttagttt ctggattatc agaagcaata
     8041 atttttttaa ctccttcttc accgattgca tcaaccgatt gaattttcac tacttgatca
     8101 actggatttc ctgtaacact tgttactgca ccatttctat ctaaatgaat aatcacatta
     8161 tctgaatcaa cagtaacgcc ttccgtttgc ttttctaact taagatgctt catcccccac
     8221 gcatcttctt ttcgatctac aaccgtatat tgttcagcag ctgcctcaga aattgcctcc
     8281 ttttccaact tcgataaaac tgttgaaact tcactttctg aataaacttg ttcttctgcg
     8341 gctacaaaaa gtgaagaaaa tagacatgaa cttccaacaa agatgcctgt acctaaaatg
     8401 tataaaattt tatttccctt catcaaacaa ttaactcctt ccccagtttc cttttatttc
     8461 ttttcccaac aaaagtattg ctttatcctc cctaattttt cccgttaaac gaccgcccct
     8521 ttccctgcgt aaatatttgt tgctattttc attatagaca actacctaac cggcactatc
     8581 taaattcctt aatcagccga catttttccc tgtattgccc ctcataactc aataccatag
     8641 caaaaaagtt gttaacaaat tcattcgtta acaacttttt tactattatg atttttttca
     8701 ataattaaat gttgagtaac cgatccttca ttgaaggacg tttgcaaatc aaattgatct
     8761 gaaaaatcaa caatttcttt tacatataac aatccccaac cgtgctcttc tgggttactt
     8821 ttagaactaa atttggtttt cttcataatt ttaaaatcaa attcggcttg gacactattt
     8881 gttatcacaa actcttgtgt ttcattttta ttgaaaattg agatagcgaa cattttcaat
     8941 tctgattttg cactgttttc aatcgcgtta tctaatagaa tagccaacaa acgaatcaca
     9001 accactaagt cgattgatgt atcaagaata aatacttctg gcacatcaac aatcactttt
     9061 agttttgctt gctttgcggt attaattttc atacttatga gtgccttaag ttccatattt
     9121 ttcaaacgat ttaacttcat aagttcaaat tcttcattat caataatttt tttggttggt
     9181 gcaatcgttt cttcataaat tcttttgatt tccagaatat cttcgtatga aatagcaatt
     9241 tgtaaactat acaataaatt tttataatca tgacgaaaca tcgctagctc ttcattaatg
     9301 gattctattt tttcagtata aatcgttaaa ttattcaata attgagtgtt gatacgttgt
     9361 tcttccaaat aagcttcaat gactaagcca atcagaatta aaaataaacc tacacttatt
     9421 aataactcca atttagaact atttaccgtg acaaatcctc gcataaagtc aggtgaaatc
     9481 tctggcgaaa tcaaaaacac aaaaagtaac aacagaatca acaataaaag taaacaacca
     9541 aaaaaaattc ggctattttc taacacacga tttaatctta aaaaaacact attgggaatt
     9601 tttaaagcaa tccagatatt tataagcaac agaagaacat ttgaggcaat ccataataat
     9661 ttattttgat aaatctgttg aaaaaaaaca cttaaaatcg tttgctccgt gtaattgata
     9721 aacgaaacca taagcaatgt aaaaacggat aaaaatatcg ctttaaaaat tgagaacctc
     9781 tttttgtgaa tgagtaaaaa tcctgtaaaa ataacgactg tcagcgcata aatcaaccaa
     9841 gagtagccca acattaatgc cgcaaacgaa caaagattaa tgacaataag caatgaaagt
     9901 aacggtattt tacattcaat cttgatcaat gttactcgta aaaagacaaa aacgataaag
     9961 ctagatacaa gcaaaacgtt agtagctaat aacgacaaaa tcatttttca atattctttt
    10021 taggtttttc agtttgtccc atccattgtc caaatatatt gggcgaattt tgatttaatc
    10081 taggcttagt tcccacacca tcactgactt ttgcaactct tttttcaata acatttttaa
    10141 ttattttttt accaaatttc ataaaaacac ttccttcaat taaatttttt gttacaggga
    10201 gtatcatcag accttggatg acgagaccgt agagtattac tgaagcaatc ttttctttga
    10261 caaacagact acataaaata agtaaacaca cccttataag gctttgcttt ttgagcacgt
    10321 ttaaatcaga tggctgaaca ggttcgattg ctgttccttg tggcgcatac caataaaata
    10381 atacgactaa gaggcaaatc aataaaattt tataaataaa cggtaagctc acagaagaat
    10441 ttttcaatac aaatggtatg gcaacataga taacaatgct ttctagacga cagagccatt
    10501 tggtttttgc atgccagcca cctgcgacag gccgtaaaaa aatcagtacg acgtatacaa
    10561 taaaggtttc gcttaacgtc ccaaataaaa ctgataaaat cagaatcatc agaaaattaa
    10621 ataagccaga aaaataaacg gttagataat actttgtcca ttgtgttttt cctgattgat
    10681 cttcctgatc catatccata atatttttta gaatccaatc gattagcata tcgccctcct
    10741 cttcaagtat tgcactaaat tataacgaat atagcgacta atagatagat aattccttaa
    10801 ttagtcatta tccctcccta agtaagaaat agtgccttga cctgagtata atatcttctt
    10861 gagactggta cttccgttcc gtctctcata gttaaaagat gcgttttata atttaatttt
    10921 gacgcatatt ttttattgat gatgattgat tgatggactc taatcaaatc tggatgcagt
    10981 tgttcaattt ttgataacgt tccataaaat tctcttttaa aatttttacc aaccattgat
    11041 acacgatgat cgtattccgt ttgaaagaaa taaatatcat taatatccat ttttatagaa
    11101 gacgctttta agttaatgat aatatattca ctttttgtct ttatattttc tttttgttga
    11161 atatatgcat cgacacatgt ttcgacctct ttttggaaat ctagaaaatc cacgttcttt
    11221 tgaataaatt gaagagctga aaccatatat ttgtaggaag ttaaaactaa ttctgtgtga
    11281 gtagaaataa atacaatcag actttcactg tctgtttttc tgatttcttt agcaacctca
    11341 aatcctgcct ggatatgatt gttcatttga atatctagga aaaagatatt tagttgggcg
    11401 tcctggtgtg ccacttgtaa taattcatct gaacgtgaaa ataaatggat tgtttcatta
    11461 taaatatttc ttgaatgtag gatatttgtt aacaatgctt ctaacgcttt tgcttgaata
    11521 atttggtctt ctaatatata aatagccatt tgttcactca tccctttctc aagaagatat
    11581 aaaattacac aacaaaagac aaatgattat aatgttcaat caatttatac accaataaaa
    11641 gagataaaaa attgattgtc tgttagtata ttcacataaa tttagtatag cgatttcagt
    11701 agtttcctgc aaacaaaaac ataaaataac aaagcatcaa gaaagagtac tttggactat
    11761 tcatcttttt ctaacgaatc atgaggacga ttgtctcttc gttgatgaaa aacaaagaat
    11821 caaccgccaa actgttcttg tcattttata catgacaaaa tcaattcatt ggtcgattct
    11881 ggttatttta atttgttagt tcacacatgg atcattgtgc taacttttta cttaaacatc
    11941 cacacttctt cctgttgaat gagtcgctta agcgccaatg taggtcacgc cactactata
    12001 agcaattgca ttaggtaaga cacgatacga aatcgtttga tcattgatga cattgctttc
    12061 agaaataatg attccatcag aagtgaccgc ttcaacaaaa gcaacatgtc catattgatt
    12121 atctgcgcca gcaactcctg gttggaaact aatcgcacga ccagctttag gcaatgaact
    12181 aacttgatag cctaatgcac gtccttttct tccccagtca ctgccatttc ccataaattc
    12241 atccacagaa gtgcccaact gtttgaaacg attatagaca taccacgtac attggcccac
    12301 gggatagcta ccactccgat tataattgat cccatcatag actggaaaat gcatttgttg
    12361 ctgttccgct tccgacagct catttttaga ttggataatc aaaccgtctg ctgtttttgg
    12421 taaatcaaat tgcgttaagt tataaaccgc aattaacgaa tttaatttat tatcgtattg
    12481 cttgtctgtt gcatatttac ctgttaaaaa acgcgttgct tgaaggtagt ttttggcttc
    12541 cgaacgccac gctggtttat aaaaatcttg atttccgtca atcccttgtc ggagtaattg
    12601 aacataatct tgcagtgagt cattatagcc accgtaatcg cgaaacccag cggaaattgt
    12661 ataaagttgg cccctctgat cagcctcttt tgttgaaaag ctaacactat ttccttggaa
    12721 cgaacctttc acgccaaaga gattataata aggttctttg gctagttgac tttcgccaga
    12781 gccactttct aaaatagcct gagctatcat cactgatgca aaaacatcgt atttttcgcc
    12841 aagttctctg gctgtctcac caattttttt aataaacgct gtggtttgtt ctgacttcag
    12901 catttcaaat gacgcaccat atgttgctaa aacttctttg ccatactccg ttaatatgaa
    12961 ctccttaaaa ggattagtca ctaccaagcg tttttcctct tttgagtctg gttgttgttt
    13021 ggcagtatag atattctcta actgagcgat tacttctggt ttctctttag aatccgcttc
    13081 cgctgcggca attaaatatt ttccttggcc aagataaaca ccattttgaa gcgtttttcc
    13141 ttcagctgtt tgccaaaaaa tcagatcacc aggttctgcc tcctctatag aacgaacttt
    13201 accaaatgtc atttgttctt gcggtgtact gccaatgtct attttaaata attgttggta
    13261 aattttttgg gcaaggaaac tactggtcaa tgcttgctcc gtcaaattaa attctttttt
    13321 tgttttccca atgtgtctta atgcttcagc caccacgact gcccgtttct tttcgccaaa
    13381 agacgacaac agtggaagtt cgtagccttt taaatttgaa gaagctattt catctacttt
    13441 gagggacgga tttaacgata cagcctgatt ttcttcaaca acgttattgg tggcttcagg
    13501 aacttgaata ggttcttcag gttcttgctt ggtcacagga acttgtggtg gttgaacttg
    13561 tggtggttgc gattgttcaa taggctgcgt gatttctgat gataccgttg gctctgtagg
    13621 ttcttttttt gtttcagaac tagtatttgt ggttgtcgtt tctgtcgttg aatgactcgt
    13681 tgattcggta gtcgtatcgg tagaactatt tgattcagat gacgaactac tagtggacgt
    13741 tgtcgatgta gcaacagttg tttcagttgt ttcggttgtt tcggttgttt caattacttt
    13801 ttcttccgaa gtaattgtcg tttccgagga cagagctgtt tgtagcgagc tacttggtaa
    13861 ttctgcagcc aacgtaacaa ctggagcgac ttccaaactc agaagaacga gaatacttgt
    13921 taaaacaagt agttgattct tgattttctt tcttttcatt cgtaaaaatc ctctcctatt
    13981 acttacttgc gcatttgcac actgtttttg tacaaatgcg ccttgtaagt taatgatacg
    14041 ctaattttgg tcttttttat ttttgaagaa taattttcct aaaccaatac ttactatcaa
    14101 tagaaaacca ctgattgacc agattggcga aacaacttca tttgcttttg gcaaagtacc
    14161 agaagtggtg gtttttgttg tcgttccacc tgctgctgtg ccctttcctg gactggttac
    14221 gctaccagtc ccgctaaccg tgccatgatt tctattgttg cctgtagagt tgctactgat
    14281 tggctcttct gccattgctt caatggcttg tgctaaaata cttaaacatt tgtccacagc
    14341 ttcttgcgtc gcacttgggt cctcaacaag tgcttttgct tgtttaattg cttcagctaa
    14401 agcttcttgc gatgcttttg taaattgttt tcctgcttta ggtttcaagg tttctgcttt
    14461 ttgaagcagt tctctcaact ttgttttatc cgcttgaagg acttgttcct ctaaactatc
    14521 caaagcagtt tttacatttt tttcagcagt atcaatttgt tcttgccgag catttttatc
    14581 agctaaaatc ccttccgctt ggtcaattgc ttcagttaag cgcgctttag actcgctggt
    14641 aaattctttt ccggcagatg gtttgattgc ttttgctttg gctatcattg cctctaaggc
    14701 ttttttatct gtaactaacg cttcttcttg taacccatcg atggcactag ttaattcagc
    14761 aaccgcttcc tcaatcattt tttgattagc tgctgggttt tccaatgtgt ttttagctgc
    14821 taaaagcgct ttttgtaaat cttgtaacga ggaggcagta aattggtgcc cttcacttgg
    14881 agtgacttgc tgcgctcgtt tgactacttc ttgtaattgg tctttattta caaggggtac
    14941 ttcttttaat tgagccattg cagtttccaa tgcgtttaga gcctctgaga cttcttcttt
    15001 tgtcgccgtt tctttcgcta cgattgcttc agccgcttga attgcttctt gcaattgttt
    15061 ttctgtttct tttgtaaatt ggtatccttc ttccggcttt cttcctcggg cttgagcgat
    15121 tttctctttt aaggtttcct tatcaacggc gacgggttgt tcttttaatt gtgcaattgc
    15181 ttcacgcaat gttttagtcg cttggtctat ttcttcttgg gtaacttttt cttgagcaaa
    15241 tactttttga gctgctgcta atgactcttc gagaactttt ttagtttctt cggtgaattc
    15301 ttgcccatca cttggtttct tcgttagccc ctcttgaatt gctttttcta aatcagcttt
    15361 attcgctaca tcaggcattt tttccaactg ttctacagcc ttttttaggt tttccacagc
    15421 agcagaaacg tctgtctgtg tggcttgttc attggctaaa acagctactg cctcatctaa
    15481 gactggttta aaaattgccc aagtttcagg cgtatattct ttttcgacac gtgcttgatt
    15541 tagcgtaatt agcgcttgta ataactcttt atctactagc tctgtgggct tcactgttac
    15601 agaaaaatct gaaagtgtgg cttgttggaa tccttggcct actaataagc cttgactcat
    15661 atcaaattgt aatggctgct caacagttgt cgcacgtttt acgcgagttg tttcttttac
    15721 tttaacttta aaggtaacta agtccattga accatttaac aattgtttat ttccttgatt
    15781 actaagaact aaatatagat tctccacatc atttgaatgt ttccgatatt tagaataatt
    15841 ttccatttgt tttgtattat tcgtggttgc aggctgaccg acaagttcaa atttgctaga
    15901 atcaaaggac atttttgtgc ttaacgcatt aatgtttttt aagtcttgac ctttaagtgt
    15961 aaaggttaat gtatcgccag gaagataggt atccttgcca ttttcattaa ccacagcaag
    16021 ggataaaccg cccgcaattt cttcgacatc aggtatctca atcccaccat ctaattgtcg
    16081 taaaacataa ctgatatcat aagcatcaat taccccattt ttatttaaat cacctttttc
    16141 aacatagcca ttaaagtcac tgtccacaga ttctaagcct gtatagtttc gataactcat
    16201 tgcatcattt tcatcaatcg ttccatcgtt agtaatgtct ccatgtaaga ttccttctgt
    16261 tcctggttgt ttgtaaaaga gcatctcacg accagagcca aaattaccta ccgattttaa
    16321 taccttcatt tcaacaaaac gatacgcttg gtccttcgtt tcaatggttt ttgtcaaagc
    16381 atcttgcttc cagttaatag gttctgaaaa ctctgtccaa ttagctccat ctttcgacgt
    16441 ccgatactgg agctgcaaaa tatttccgtt gccggcattg tctcttggca agtattcaat
    16501 tttatccatt tgatactccg caccaagatc aaattttaaa gacaagaaat ttccatcact
    16561 tggattagcg atgcctgttg accagttcgt atgccaacct gtactcaaat ctttatctgt
    16621 taatttcttc aattctgcgc ctggttgttc tggtaaatta cttgttgctt tgacttgatt
    16681 aattgtttct ttatagggat catcttgtgt tttcccttta atcggttcac tccattcaga
    16741 gaccccattt tttccaacag ctcgaactcg aaaagtatgt tcgcttagga aggaaaatcc
    16801 atcaaatgtt gctgtattcg tttgaatatt tccgaaaaca gttccgtcac gctctacttc
    16861 atagcttgtt gcctcagtta cttgatccca ttgaagagtc aaagaagatg gcgttgtttt
    16921 ttcttcattg attgcgacat ttgccggaat agttaactgg tcatcgaccg ttgtatttcc
    16981 tccgtcaacc gttcctttat taatgaaacc tttgacagtt atttgaacat ctttggcggt
    17041 cacagattgt ttcgctagtt ttactgataa cgctgattgg ttcagttttt ctcctgaagc
    17101 ttcagaaaga tactgattca cttggaattc tttatcaaaa taatatagat ttgtaccagc
    17161 taaaaattct tctttattag ctgcttgttt caaggttact tctgttcccc ccaccattgc
    17221 tgttacgctt tcgggcgctt ctgaagctag caaatcaagc gtggtgcttc gttcatcaac
    17281 aaagccacta taacttcctt ttgtcggttc gatagtaacg gtcagatccc ctttttcgtt
    17341 tgatttaggg ccttgactat ttattttagt cgtagctgat tgcccagctt cataactagt
    17401 tgaaattccg tcatcttcat acatattaaa agaagtggcg ccatttggat aaatcaagaa
    17461 agatcgttga tcccgttgga tttcctttgg attgttgttt ggattcgtca ttgggataat
    17521 actgccatct ttgacgaaaa cgggcacctt ccacagcggt gtttttactc catttaagac
    17581 acggccacct tgatattttt cgcctgtaaa taagtcaacc cagacttgtt tttcatctgg
    17641 taagtagatt ccatcacgga ttgaatttcc tgcctcatct tgattgccat tataaattgg
    17701 ggcaacgagt aaattgggtc cccacatata ttggtattga gaatcttttg tatatgctgt
    17761 tccttcatta ggaaattcta aagccatggc ccgtaccatt ggtagtccat caactgattc
    17821 cttggcaata ctgtagttat aaggcatcat cattgatttt aattttagat acgctcggtt
    17881 caaatctgtg gcttcttgat caaaagcaaa tggcgttttt ggattggagc cccagccgtc
    17941 catatttagc tgcactggtg taaaagtttt ccattggaaa tcacgtatgt tgacctcttt
    18001 attttttcca ccaaaaattc catccatatc tgaaccgaca tttggttgtc cagacaacga
    18061 agtcccgata tatgttggga tatggaagcg aatatattcc cattgaccac ccgtttgatc
    18121 gcctgtccaa ataccagcgt gcctttgggt tccggcccaa ccatctaatg aaacaatcat
    18181 cggacgaact gcgccgtctg tttcttttac aaaaacattc gcggcatctt ctacaccatt
    18241 taagccaaag gaatacccat acccgaccca cgccacgtca gttttgagag ctttaacacc
    18301 agcgacacta acttctttcg caatatcccg ttctcctttt ttaggatttt taggatccgc
    18361 tggatggaga ttagattgag tccacagccc cacttcaaca ccattggctt gagcatactc
    18421 tgtaaattct tttaagtttt gtacatcgcc gtccaatgaa tctgtttggc catagccagc
    18481 accgtagccg tcatttggca agaaccaccc taacggcata tcgtttttct tatatcgatc
    18541 aataactgcg cgtgcagaaa attgataatt ctctttttct ccatttaaag attctagcgt
    18601 gccatttaag tttcctagat cgcctggttg gtattctttg taaaaattac catcttcaaa
    18661 cttaactgct cccgcggttc cttctgctac ttttacccaa tagtcccgat tatacgcgtt
    18721 taaatgcgct tcatagaacc cgtattctgg catcaaagct ggtttcccgg ttaattcata
    18781 gtaatctttt aaaatacctg ctgaggaatt attaaagaaa taaaaggcat caaaatctgt
    18841 tccttcgtgc gttgttgtgg ttgtttgtgg atcatgactt ccaaaatcat agttgccagg
    18901 tttccatgta tttcgaacaa cgccataccc tgcagttgac caataaaatg ggttaggcga
    18961 tgctactccg ccatctaccc aattgttcgt attgacaatc tggatagctg ttcctttatg
    19021 cgtaaatcga ccattttgag ttcctccgcc aaaataattt tcttgactac tttgttttaa
    19081 cgtttgtgta gctttatcat ttttaaagga tagcggagcg gtttcttcta aaatgacttg
    19141 atcctttttc ttgtctagaa ctttaattaa agcgctttct ttttcgaaca taatttttaa
    19201 accattattt tctagaataa attggtttcc tgaatctgtg acgttcgttt gctcaaaggc
    19261 ttgtgtacca tagtcggcca ttgttttagc cgtaattttc gcaacatgct ttggatcatt
    19321 tggcgttgga tattcttcaa atttaccagt tggatctaga tgatagcgaa aaagatggtc
    19381 gtttaaaata ctaatttgtg ctttttttcc agaagcatac gtaatgacaa agtttttctc
    19441 cgctttttca atcgacacaa ttgctccgac tgacgttgct gaatcagcta cttcttcttt
    19501 tgctgtttgc tcttgcgcat caaccacttg agaatccatc gtaacaaaca aatggaacgc
    19561 caatacagac gaactcacta ataaaaatgt caaccagtgc tttttaccgt aaattttttt
    19621 accctgatac tctttgttca ttttttcctc cttaaaattg ctccccatag aatagttccg
    19681 acacaattac tcacaaaatc caaaacccaa caaagtttta tccagatgaa aagtcataac
    19741 gattttctta gtttactgag actgttagaa agtcagtttc agtaacccct tcataaacac
    19801 atcctttcaa taaaatatta aatgaaaaca atctattttc atcttatata aaaattttag
    19861 tacagaatca caatttcccg atgaatgcgt tttcatttgt tgactaccaa tttttcactt
    19921 ttttaataac ataattatcg tatgatggtt tttttgtgtt tgtcaacggt taattatagc
    19981 agccaccatt aacaagtatt aacccttgat aaacctgtta attcacttat aatgatgatt
    20041 ttattgcgaa aatatctaca tcagaaaaag aaagactttt ttcaaaaatc taatacctgt
    20101 tgctcaaatc tagtctattt aaaaataatc aacaccctcc tgctcagcaa gagggtgtta
    20161 attactcgtt ttttagtgat tgatttgact tgctggtgtg aaaagcaaac taatgatgat
    20221 gccaactatc agtaccgcta gcaatataaa aattaacttt ccaaaccggt gatagggatt
    20281 gatcgaaagc ccaatcccat aaactttcgg aacccacaaa ggaggcgttg gattatcttt
    20341 ttgatcttta taggctatct ttaaaatctg ccacgcaaaa tacaacaatg gtaaaaccat
    20401 aattacccca actataccta gccattttgc taataaatca ctagtatgca aaagactgat
    20461 tgtcagaatt ggtacaaaca aaagaataaa gctaattgtg gctcccactt gtgcttgctt
    20521 aagcagccgt ctctcacgga gagtaagatt cgcaaacatt ccatccaccc tttcatggtt
    20581 ttcagattaa atcaacgaat cactaaaaaa ctaaattaac tgcgaaaatc aatgaccatt
    20641 cgcccgcgaa tttttccttg ttccatttct tcaaaaatag cattaatttc ttctggttgg
    20701 cgtgtttgac aaacaggaac aacttttcc
//
