LOCUS       NZ_KB944666            22985 bp    DNA     linear   CON 09-DEC-2024
DEFINITION  Enterococcus faecalis EnGen0336 strain T5 acAro-supercont1.1, whole
            genome shotgun sequence.
ACCESSION   NZ_KB944666
VERSION     NZ_KB944666.1
KEYWORDS    WGS; RefSeq.
SOURCE      Enterococcus faecalis EnGen0336
  ORGANISM  Enterococcus faecalis EnGen0336
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Enterococcaceae; Enterococcus.
REFERENCE   1  (bases 1 to 2806553)
  AUTHORS   Earl,A.M., Gilmore,M.S., Lebreton,F., Walker,B., Young,S.K.,
            Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B., Abouelleil,A.,
            Alvarado,L., Arachchi,H.M., Berlin,A.M., Chapman,S.B., Dewar,J.,
            Goldberg,J., Griggs,A., Gujja,S., Hansen,M., Howarth,C.,
            Imamovic,A., Larimer,J., McCowan,C., Murphy,C., Neiman,D.,
            Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T., Sisk,P.,
            Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Enterococcus faecalis T5
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2806553)
  AUTHORS   Earl,A.M., Gilmore,M.S., Lebreton,F., Walker,B., Young,S.K.,
            Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B., Abouelleil,A.,
            Alvarado,L., Arachchi,H.M., Berlin,A.M., Chapman,S.B., Dewar,J.,
            Goldberg,J., Griggs,A., Gujja,S., Hansen,M., Howarth,C.,
            Imamovic,A., Larimer,J., McCowan,C., Murphy,C., Neiman,D.,
            Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T., Sisk,P.,
            Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (21-FEB-2013) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R42411
            Assembly Name                     :: Ente_faec_T5_V1
            Genome Coverage                   :: 289.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000393015.1-RS_2024_12_09
            Annotation Date                   :: 12/09/2024 13:32:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,757
            CDSs (total)                      :: 2,690
            Genes (coding)                    :: 2,666
            CDSs (with protein)               :: 2,666
            Genes (RNA)                       :: 67
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 8 of 24
            Pseudo Genes (incomplete)         :: 14 of 24
            Pseudo Genes (internal stop)      :: 4 of 24
            Pseudo Genes (multiple problems)  :: 2 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:17:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 90665
            Orig. end                         :: 113650
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB944666.1.
            Please be aware that the annotation is done automatically with
            little or no manual curation.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22985
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22985
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22985
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12985](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12985)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(57..1613)
                     /db_xref="GeneID:60892410"
                     /gene="rny"
                     /locus_tag="WMS_RS03500"
                     /old_locus_tag="WMS_00084"
     CDS             complement(57..1613)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_process="GO:0006402 - mRNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892410"
                     /gene="rny"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005875117.1"
                     /locus_tag="WMS_RS03500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00084"
                     /product="ribonuclease Y"
                     /protein_id="WP_002354863.1"
                     /transl_table=11
                     /translation="MVLNILLAIVGLIVGLGLGFVIAKSRHDKAINGAKISASSILENA
                     RKESETLKKEALLEAKEENQKYRSEIESELKESRLELKSQENRLIQREQTLDRKDDSLE
                     KREGSLEEKEEKLGARQQLIDEREKEVENLINQQHQELERIASLSKEEAKSIIMKSTEE
                     ELNHELTLMVKESEQRAKEESDRKAKNLLSLAIQRCAADSVSETTVSVVTLPNDEMKGR
                     IIGREGRNIRTLETLTGIDLIIDDTPEAVVLSGFDPIRREIARMTLEKLIQDGRIHPAR
                     IEEMVEKSRKEMDERIREYGEQAAFEVGAHTLHPDLIKILGRLRFRTSYGQNVLNHSIE
                     VAKLAGVLAAELGEDVQLAKRAGLLHDIGKALDHEIEGSHVEIGAELAAKYKENSVVIN
                     AIASHHGDVEATSVISVLVAAADALSAARPGARSESLENYIRRLENLENISNSFEGVDS
                     SFAVQAGREVRVMVKPEEISDLESVRLVRDIRKKIEDDLDYPGHIKVTVIRETRAVDYA
                     K"
     misc_feature    1889..1903
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(2010..3056)
                     /db_xref="GeneID:60892411"
                     /gene="recA"
                     /locus_tag="WMS_RS03505"
                     /old_locus_tag="WMS_00085"
     CDS             complement(2010..3056)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008094 - ATP-dependent activity, acting
                     on DNA [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892411"
                     /gene="recA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354860.1"
                     /locus_tag="WMS_RS03505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00085"
                     /product="recombinase RecA"
                     /protein_id="WP_002354860.1"
                     /transl_table=11
                     /translation="MADDRKVALDAALKKIEKNFGKGSIMKLGEKADQKISTIPSGSLA
                     LDVALGVGGYPRGRIIEVYGPESSGKTTVSLHAIAEVQRNGGTAAFIDAEHALDPQYAE
                     KLGVNIDELLLSQPDTGEQGLEIADALVSSGAIDIVVIDSVAALVPRAEIDGEMGASHV
                     GLQARLMSQALRKLSGSINKTKTIAIFINQIREKVGVMFGNPETTPGGRALKFYATVRL
                     EVRRAEQLKQGTDIVGNRTKIKVVKNKVAPPFKVAEVDIMYGQGISQEGELLDMAVEKD
                     LISKSGAWYGYKEERIGQGRENAKQYMADHPEMMAEVSKLVRDAYGIGDGSTITEEAEG
                     QEELPLDE"
     misc_feature    complement(3150..3165)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.58"
                     /tool="antismash"
     misc_feature    3151..3164
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: strong, score: 22.72"
                     /tool="antismash"
     gene            complement(3170..4414)
                     /db_xref="GeneID:60892412"
                     /locus_tag="WMS_RS03510"
                     /old_locus_tag="WMS_00086"
     CDS             complement(3170..4414)
                     /codon_start=1
                     /db_xref="GeneID:60892412"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002365395.1"
                     /locus_tag="WMS_RS03510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00086"
                     /product="competence/damage-inducible protein A"
                     /protein_id="WP_010819079.1"
                     /transl_table=11
                     /translation="MKAEIIAVGTELLLGQVVNTNATFLSEELAALGIDVYYQTVVGDN
                     GGRLETLLTEAEQRSDLIVFCGGLGPTEDDLTKQVVAQHLHKSLVEDQEGLNRLHQFFQ
                     QSKRPMTENNLRQVLAIEGGQVLQNPTGLAVGSFVTEGTTSYLLLPGPPNELIPMFQQA
                     ARPLLINAFPQEEQLISRVLRFYGIGESQLVTEIQSLIAHQTNPTIAPYAKPNEVTLRL
                     TVKTKDLVAGEELLTATEEKVLAKVGDYFYGYGDDNSLAKVTVDLLLQNGQTVTAAESL
                     TAGLFQSTLGEIAGASKIFKGGFVTYSQETKENFLGISHELLEEHGTVSEACAKEMAEK
                     ARQLAKSNYGLSFTGVAGDPIEGQPTGTVWIGLAEEGQPTVAECFHFNRDRNYIRQSAV
                     MRGLDLLRRRIINKK"
     gene            4606..5811
                     /db_xref="GeneID:60892413"
                     /locus_tag="WMS_RS03515"
                     /old_locus_tag="WMS_00087"
     CDS             4606..5811
                     /codon_start=1
                     /db_xref="GeneID:60892413"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016627528.1"
                     /locus_tag="WMS_RS03515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00087"
                     /product="hypothetical protein"
                     /protein_id="WP_010819080.1"
                     /transl_table=11
                     /translation="MSVVLVLLGLLGLLVSGGLTIKALIKKQPKKQYGYAALASAALFI
                     GGVATTDSSPTLSLDAESVETDANGSATIKGEYDGNSKLTANGKEVKTKDKTFAYKVKL
                     SDEKTQKITFVAEKKDTKVEKSVEVTPSKEFIASITDSEQELAKTEKALAYAEKQPSQK
                     NYDEAATLVSSLSQEYEKYNDRLEKIKEAVPVDEAVTTAEKSKSKSDYQAAEKLVAAAP
                     VGKEGFQQRLTTVQTAIAEKEKNEQLVASATAAVEKAEQEPSNEAYYNEAVKQIDALNS
                     PNQALTKRVAVVKTQLDAHKEKQRKEAEAQKLAAEKAQKEQAEAAAKAQAEAEAQQAAQ
                     APAEVETAAAEAPSGNALIKGSRNGIYHVPGSRYYNRTTNPVAWFSTVEEAEAAGYRAP
                     KQ"
     gene            complement(6037..>6141)
                     /db_xref="GeneID:68864506"
                     /locus_tag="WMS_RS17650"
                     /pseudo=""
     CDS             complement(6037..>6141)
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]"
                     /GO_function="GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]"
                     /GO_process="GO:0051290 - protein heterotetramerization
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:68864506"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002334253.1"
                     /locus_tag="WMS_RS17650"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system RelE family toxin"
                     /pseudo=""
                     /transl_table=11
                     /translation="RYRIGNYRILANICDSKVVIQIFPIGHKGTIYKE"
     gene            complement(<6144..>6248)
                     /db_xref="GeneID:96990715"
                     /locus_tag="WMS_RS17800"
                     /pseudo=""
     CDS             complement(<6144..6248)
                     /codon_start=1
                     /db_xref="GeneID:96990715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383791.1"
                     /locus_tag="WMS_RS17800"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="antitoxin"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDDEIDLKTLRNAMEISKEKKEIGISQEQMEKLLN"
     CDS             6257..6400
                     /gene="allorf_0096922_0097065"
                     /locus_tag="allorf_0096922_0097065"
                     /protein_id="allorf_0096922_0097065"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGAPRNICTENSDSD
                     YL"
     CDS_motif       6257..6355
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA"
                     /locus_tag="allorf_0096922_0097065_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       6356..6400
                     /prepeptide="core"
                     /locus_tag="allorf_0096922_0097065_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.70"
                     /molecular_weight="1572.6"
                     /monoisotopic_mass="1571.7"
                     /core_sequence="PRNICTENSDSDYL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA"
                     /leader_location="[6256:6355](+)"
                     /alternative_weights="1590.7"
                     /alternative_weights="1608.7"
     gene            complement(6871..7134)
                     /db_xref="GeneID:60892414"
                     /locus_tag="WMS_RS03525"
                     /old_locus_tag="WMS_00088"
     CDS             complement(6871..7134)
                     /codon_start=1
                     /db_xref="GeneID:60892414"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002396818.1"
                     /locus_tag="WMS_RS03525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00088"
                     /product="hypothetical protein"
                     /protein_id="WP_002396818.1"
                     /transl_table=11
                     /translation="MRYSLEDRADNRINAVAAVYKDESKDLIRESNTHRCGVCGEEKTC
                     TTILDFDNLIRKNMLNIKYDYKFNQCVALYDRKEEFNLVKRM"
     misc_feature    7113..7130
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 24.35"
                     /tool="antismash"
     gene            complement(7138..9267)
                     /db_xref="GeneID:60892415"
                     /locus_tag="WMS_RS03530"
                     /old_locus_tag="WMS_00089"
     CDS             complement(7138..9267)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892415"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002424924.1"
                     /locus_tag="WMS_RS03530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00089"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_010819081.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.4e-33, bitscore:
                     110.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIKVVYQNEHSECGIAVVTSILNFFGSRVTINDLRDKYGSPKG
                     GLTFGNMNYIMKKFGLIYHGIKINDTDYLKNQKKPVILFWDNNHFVVFYKYKRGHFYVM
                     DPKLGKVVYTKHEFEEHFSLYALVFKEINYNDGKKEIKINLKNKTKELICSLLRSTKSI
                     IILMIFVIFLSKMLSLIVPVLTQRLIDNYQILANLSLATLIGGTILIAGIYYLITVSYS
                     LLLTKLQLSWSKKLSNKFMEKVFIKSLNFFVNRSSGSMIYKANLITMVQQMLSKNTIEN
                     IIDYLFMIVYFIYLTNYSSKLTIITIIFCLLILINSLTYSKINYKINGRVIEYQSEIQS
                     LYVEIFSGMETIKSLGKEKVFFTRWSNIFSNSLKSLSQQGKAAAWLSRISTTLLFTLPI
                     IILFFGIHEVQANQMSLGQLIGFTTLIAYFIEPFSTMIGSISQILILKSYLNQISDVTN
                     TDFYNEINGKKKFERFENLKMNNVNFSFSEFEKNVISSVNLEIKKGEKVAIVGKSGSGK
                     STLLKLICGLFIPSEGQVIYNNEEISSFDKSSLRNKVGYVTQSSIVFGNTLEENLMVGD
                     ESPIVVKEVLTATGINELVDNDMLGLNTIISENGMNLSGGQKQKISIARCLLKNPDVII
                     MDEPTSSLDNVSEKKIMDYILNNCKTSVIVAHRLNTIKNMDRIIVLDKGRVVEEGNHEQ
                     LLEMQKVYYSLYNEM"
     gene            complement(9274..9975)
                     /db_xref="GeneID:60892416"
                     /locus_tag="WMS_RS03535"
                     /old_locus_tag="WMS_00090"
     CDS             complement(9274..9975)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892416"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010710868.1"
                     /locus_tag="WMS_RS03535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00090"
                     /product="flavodoxin family protein"
                     /protein_id="WP_010710868.1"
                     /transl_table=11
                     /translation="MKKILAIIGSRDKNSETLSIVNRIKETVQDLNASFEFEIITPYDY
                     NLNFSDSPRLAFIKGADTNEQDERDDSKKIKAKIENASLVILASPTYFANVSADIKLFI
                     DRFCHLAHLFYFAKKPCITVVTSDGNGHIQTSNYLKSFCDGLGMVRVQEIISIRSNPIS
                     ENEIEASVREGLKYISNPQKISPNLSMEMSFQHWKKSISKQNETLSEYRYWENSGLFSC
                     NSLEEYFDRYR"
     misc_feature    9997..10010
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.16"
                     /tool="antismash"
     gene            complement(10001..12985)
                     /db_xref="GeneID:60892417"
                     /gene="lanM"
                     /locus_tag="WMS_RS03540"
                     /old_locus_tag="WMS_00091"
     CDS             complement(10001..12985)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892417"
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401133.1"
                     /locus_tag="WMS_RS03540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00091"
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_010819082.1"
                     /sec_met_domain="DUF4135 (E-value: 7.7e-88, bitscore:
                     292.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7e-48, bitscore:
                     160.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCFDKGKALTIEERMSLIKNKIFDDKNSSNIQRWLNRKTTVDSE
                     LFSKILNINNWKLEEFNHCIDENFKIDSYSDRVTYSDFDSLIASIEDQNNLPSTYVKLI
                     RPFLTKLENGLIVDFQDKLSEKAIENIFDCLASRLINLSLKVFVLEMDFIKNSNGLHGE
                     TSKERFINFIDLYDDKEKLLNLYQKYPVMTRKLSITTLYFIDFMNEFLNNLFQSWDSIE
                     DTFFDTEEKIYVESLIFEKGDTHEKGKSVVIIEFNLGKIVYKPRNLYIEKNFQKIIKFF
                     SYSNGFLNMDIPKSLYNSTFTFVQFIEQEPCNNEEEIERFYQRYGQLIALIYLTNGSDI
                     HFENVISHGEYPVIVDYETLFSVPIKLEGRQENIFSEIVGFIRNSVSSSIMLPGKMQLD
                     SEGNSVDISGLSGKTQKLEKKMYVPKNLDNDNAKFVLENVILEGSNNNVFYKDKLINYQ
                     DYYKEIIAGFSNVMDFFLVNKEEYLNLIEGMENNTIRILARNTNTYAQFLEFTKHPNCL
                     KDFVELEKILENLYTFPYENKQISQLEYKDMVFDDIPIFFSKLDENCIYNSEGVRIQNV
                     FENTPRIFLIDKIKNIDSENISKQIGIIMMKIKGEEGVVKQDVSSLVISKEDSYLQIAE
                     KLAEKLIDSAYIDKNEEYMTWLVINDGVVDEFDLGASKVNFYDGLIGIASLFKSLYKVT
                     GKVKYQRYFDYLVKTTMDLLDTMQTDSAYVGFHSFLQLFSIIEKEDTNYERITHYLNLL
                     QQNSQNFLEREGTVDWLLGYGGIIPLYIDVYKKTKDNQYLEIAIFLGNKLIMFAEKDTN
                     VMKNIGIGHGISGLLISMVELYKVTKDRQYLEYIKKLNERMSISLVQENEDVVSWCNGI
                     LGYLLGQSYLHKNNIKSALSDKEKQRLLLKIKNQYLESDCLCHGNCGIIQFYIDLYLLE
                     NSDKYLEHAKKIGNKMISEIIKNEYIQIREFEGFDNIGLFNGISGVAYTLVRLLEPENV
                     PSVFV"
     misc_feature    complement(13020..13033)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.36"
                     /tool="antismash"
     gene            complement(13137..13334)
                     /db_xref="GeneID:60892418"
                     /locus_tag="WMS_RS03545"
                     /old_locus_tag="WMS_00092"
     CDS             complement(13137..13334)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892418"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002396812.1"
                     /locus_tag="WMS_RS03545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00092"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_002396812.1"
                     /transl_table=11
                     /translation="MDEKQLDSLVGQKFEDLSKEEMNFIAGGNDNARISPTIILSAATV
                     ASAASSFVGSYTLSAFTKCR"
     CDS_motif       complement(13251..13334)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MDEKQLDSLVGQKFEDLSKEEMNFIAGG"
                     /locus_tag="WMS_RS03545_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13137..13250)
                     /prepeptide="core"
                     /locus_tag="WMS_RS03545_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.50"
                     /molecular_weight="3594.0"
                     /monoisotopic_mass="3591.9"
                     /core_sequence="NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDEKQLDSLVGQKFEDLSKEEMNFIAGG"
                     /leader_location="[13250:13334](-)"
                     /alternative_weights="3612.0"
                     /alternative_weights="3630.1"
                     /alternative_weights="3648.1"
                     /alternative_weights="3666.1"
                     /alternative_weights="3684.1"
                     /alternative_weights="3702.1"
                     /alternative_weights="3720.2"
                     /alternative_weights="3738.2"
                     /alternative_weights="3756.2"
                     /alternative_weights="3774.2"
     gene            complement(13355..13564)
                     /db_xref="GeneID:60892419"
                     /locus_tag="WMS_RS03550"
                     /old_locus_tag="WMS_00093"
     CDS             complement(13355..13564)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0005488 - binding [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892419"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401134.1"
                     /locus_tag="WMS_RS03550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00093"
                     /product="lichenicidin A2 family type 2 lantibiotic"
                     /protein_id="WP_002401134.1"
                     /transl_table=11
                     /translation="MEAEKIVGMQFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSY
                     VASAAGSAALSAVSGLVSYTKKCF"
     CDS_motif       complement(13538..13564)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEAEKIVGM"
                     /locus_tag="WMS_RS03550_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13355..13537)
                     /prepeptide="core"
                     /locus_tag="WMS_RS03550_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="1.60"
                     /molecular_weight="6041.7"
                     /monoisotopic_mass="6038.1"
                     /core_sequence="QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGS
                     AALSAVSGLVSYTKKCF"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEAEKIVGM"
                     /leader_location="[13537:13564](-)"
                     /alternative_weights="6059.7"
                     /alternative_weights="6077.8"
                     /alternative_weights="6095.8"
                     /alternative_weights="6113.8"
                     /alternative_weights="6131.8"
                     /alternative_weights="6149.8"
                     /alternative_weights="6167.9"
                     /alternative_weights="6185.9"
                     /alternative_weights="6203.9"
                     /alternative_weights="6221.9"
                     /alternative_weights="6239.9"
                     /alternative_weights="6258.0"
     gene            13718..14221
                     /db_xref="GeneID:60892420"
                     /locus_tag="WMS_RS03555"
                     /old_locus_tag="WMS_00094"
     CDS             13718..14221
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892420"
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002424923.1"
                     /locus_tag="WMS_RS03555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00094"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002424923.1"
                     /transl_table=11
                     /translation="MNTGEKIRKYRMEKNLSQVELSSILLVSRQTISNWENGRTRPEME
                     NLVLISNFFDVPLEVFLSEDISEIKKQHTEFTFTAKIIFIIFISICVLISSIFMSIKMS
                     KYFLVFPFLLLNIIFACLLTFFLRQTPEKSYLKKFNKLNFLFIILIMGLISFFSIYFLL
                     TLLN"
     gene            14339..14692
                     /db_xref="GeneID:60895035"
                     /locus_tag="WMS_RS17490"
                     /old_locus_tag="WMS_00095"
     CDS             14339..14692
                     /codon_start=1
                     /db_xref="GeneID:60895035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002407847.1"
                     /locus_tag="WMS_RS17490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00095"
                     /product="hypothetical protein"
                     /protein_id="WP_002407847.1"
                     /transl_table=11
                     /translation="MSNEVKKMISLTWILFLVSIVTMISIGITFKFWGLKGLLIPVFEC
                     SLIAYIGFKIEIIRRRINIKSYNELLNILHYDSLKSTTSPSRKNFFLEKNLLAFLISFV
                     FFLLIISISFVIF"
     gene            complement(15099..15221)
                     /db_xref="GeneID:68864507"
                     /locus_tag="WMS_RS17655"
     CDS             complement(15099..15221)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:68864507"
                     /inference="COORDINATES: protein motif:HMM:NF013828.5"
                     /locus_tag="WMS_RS17655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_224799193.1"
                     /transl_table=11
                     /translation="MKNRANFFFQLINLRYEKKSTVLTSNIALFQWTEVFQDKR"
     gene            complement(15883..16512)
                     /db_xref="GeneID:60892421"
                     /locus_tag="WMS_RS03565"
                     /old_locus_tag="WMS_00096"
     CDS             complement(15883..16512)
                     /codon_start=1
                     /db_xref="GeneID:60892421"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354854.1"
                     /locus_tag="WMS_RS03565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00096"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_025189783.1"
                     /transl_table=11
                     /translation="MIYMKVAVLGATGKEGQLLLAEAKRRGMDVTAIVRNASKITDGTP
                     TIEKDVYQLTTEDIQAFDVLISALGFPDVQDFPKSTQHLIEILTNQKTRLFVVGGAGTL
                     YVDPEHTTQLKDTPSFPAEIQPLASAMGEALNLLKEAQNIHWTYISPASMFDAEGPATG
                     HYEVAGEELTTNSQGDSYISYADYAVAMLDEVESNAHPNQRISVYQ"
     gene            complement(16571..16996)
                     /db_xref="GeneID:60892422"
                     /locus_tag="WMS_RS03570"
                     /old_locus_tag="WMS_00097"
     CDS             complement(16571..16996)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892422"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002383201.1"
                     /locus_tag="WMS_RS03570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00097"
                     /product="Rrf2 family transcriptional regulator"
                     /protein_id="WP_002383201.1"
                     /transl_table=11
                     /translation="MAMSTKLSVAIHILSLIETGPQEQVTSEYIASSVNTNPVVVRRLM
                     SQLKKAGLIHSMRGANKNTLLKKPEEISLYEIYTAVELEREIFNIHQNPNPNCSVGANI
                     QSVLETEFTKVQQKMEEELKSITLADVIHEIEVKRDK"
     gene            complement(17085..17468)
                     /db_xref="GeneID:60892423"
                     /locus_tag="WMS_RS03575"
                     /old_locus_tag="WMS_00098"
     CDS             complement(17085..17468)
                     /codon_start=1
                     /db_xref="GeneID:60892423"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002354850.1"
                     /locus_tag="WMS_RS03575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00098"
                     /product="YccF domain-containing protein"
                     /protein_id="WP_002354850.1"
                     /transl_table=11
                     /translation="MKTLGNILWFIFGGFFGGLSWLFAGVIWCITIIGIPIGLQCFKLA
                     GLSFWPFKKRVVYSDSGVSLVVNIIWLIISGLPLAIGHCISGLLLCLTIIGIPFGQQSF
                     KLAKLALMPFGARVVSTTDFYFE"
     gene            17632..18423
                     /db_xref="GeneID:60892424"
                     /locus_tag="WMS_RS03580"
                     /old_locus_tag="WMS_00099"
     CDS             17632..18423
                     /codon_start=1
                     /db_xref="GeneID:60892424"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002367471.1"
                     /locus_tag="WMS_RS03580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00099"
                     /product="hypothetical protein"
                     /protein_id="WP_010819084.1"
                     /transl_table=11
                     /translation="MDLHLTVDLKKTKTLIDLADQAHLIIEQTTKLPKKEAAILFLLRD
                     NQLVALGLAEEKATYKEVSFDHSILLKPTWDTELAYLAQAFLDDAKESGLTLEATPTTV
                     KIPKSAVATVTNYKETVTFILERFGYSLFNKPAPKKARPAKARHKWTKEVSQIPFYIDT
                     RQSKATVFWQKRNEMLIKAGATMMPEAPLNKDGSVGFSARFGEKLRDERKGQFKDFVTT
                     EDIVLKSVNEVGLFLYFAGTNSWLELVDENGKTLNEWTVVE"
     gene            complement(18476..19612)
                     /db_xref="GeneID:60892425"
                     /locus_tag="WMS_RS03585"
                     /old_locus_tag="WMS_00100"
     CDS             complement(18476..19612)
                     /codon_start=1
                     /db_xref="GeneID:60892425"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002365400.1"
                     /locus_tag="WMS_RS03585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00100"
                     /product="ArgE/DapE family deacylase"
                     /protein_id="WP_010819085.1"
                     /transl_table=11
                     /translation="MEKSEKISILQDVVKIKSVNGNEEEVAIYLQNLLKKYEIPSELVS
                     YAPNRSSLVAYLGENREKVLGFSGHMDVVSEGDESQWTFPPFAAHIEGNKLYGRGATDM
                     KSGLVAMVLAMIELKEKEVPLKGAVKFLGTVGEEVGELGAGQLTEKGYADDLSALVIGE
                     PTNYNLMYAHMGSINYSVVSHGKEAHSSMPEEGINAINNLNEFITEANQQMAEVTANYE
                     NPELGRTIHNVTVIKGGTQVNSIPGQAALQGNIRSIPEFSNDQVIALLQKIVDELNKKE
                     KHQLELTIDYNKIPVKAEKDSALIQAIQAQFDQPLPLVTSAGTTDLAEFTKSDNTFDCV
                     VFGPGVTTTAHQVDEYVEIDNYLDMIDKYQAIAKSYLN"
     gene            complement(19742..20626)
                     /db_xref="GeneID:60892426"
                     /locus_tag="WMS_RS03590"
                     /old_locus_tag="WMS_00101"
     CDS             complement(19742..20626)
                     /codon_start=1
                     /db_xref="GeneID:60892426"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402522.1"
                     /locus_tag="WMS_RS03590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00101"
                     /product="RsiV family protein"
                     /protein_id="WP_002365402.1"
                     /transl_table=11
                     /translation="MEDFVKSVVKNFSKEYRQQPLPTDLQAEVKARFHKEKKRYTWLRF
                     RNRSLQSSLVVACGFVLSVNLFPGFSEAARNIPVLDKIVQLVTIKTLTAKKQESEVNID
                     VPKIQTSQESSVADTLNKKYLKEAQTEFQQVKGQLFDGSRVSVTGDYEKVVDDRRFLVV
                     KRTFTEIKGSSATTTKYDTIDKRANVVVSLPLIFKNDFYIDVISSEIKQQIADQMKNDS
                     NKIYWSEKEDAPSDVQPFKKIKKDQPFYINEKHQLVIVFPQGEIAPYYMGTPEFVIPNQ
                     VIENELAAPNYLK"
     gene            complement(20651..21148)
                     /db_xref="GeneID:60892427"
                     /locus_tag="WMS_RS03595"
                     /old_locus_tag="WMS_00102"
     CDS             complement(20651..21148)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:60892427"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016618616.1"
                     /locus_tag="WMS_RS03595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00102"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_002360979.1"
                     /transl_table=11
                     /translation="MVFDGWKRKKQIRALETLVDTKYEKMYRIAFNYTHSKEDALDVIQ
                     ESFEKALKAIQKGPDIKDFDAWFFRILLSVATDYWRKKKREAVHIEKDEHVLALLNNPQ
                     RSFLEIEEIINQLDSPNREIILLKFFEGFTLKEIALILDINENTIKTKMYRSLNELRSL
                     LN"
     gene            complement(21385..22866)
                     /db_xref="GeneID:60892428"
                     /locus_tag="WMS_RS03600"
                     /old_locus_tag="WMS_00103"
     CDS             complement(21385..22866)
                     /codon_start=1
                     /db_xref="GeneID:60892428"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002368476.1"
                     /locus_tag="WMS_RS03600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="WMS_00103"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_010819086.1"
                     /transl_table=11
                     /translation="MILMMFLNKVDKRKIALFQLLENAPMLTESKETVMQELELSEFIV
                     NKTVAELNADFIEFGLSEDFQIVSDGIFLTLNESGTETSDTLIDCYIKESLRFAMFQDF
                     FFQRFDSVNEFALEHFVSHTLAYKEFKELKKMLENYQITINKEFHLVGNETNLREVTTL
                     VFLQLYQRDFSLYGKKVLEQIRNFELFFSEKVHLNQRAGYAQAKCFHFLAVSLVRTQQQ
                     FYVEKKVDSQVLKQLAGDNQQNVFNWLESLQVPEPQRINEGNYLLLFLIAEEWLQVASA
                     ALCQRFAEIQQLNRDLLSYLKIQFQLSEEVLRGFEQKVTIVHFKLFHFPIEANYSYRKM
                     DITYFAETYTEYFSASRQFIQEQKTNPAVWDARQFLFYRYLLLMVDALPLKKVLAPITL
                     CVDFSFGEAYNRMIQKNIEKITEWNIIFKAHVDESVQLILSDIHFVDWPEITQIIWLAP
                     PRPVDWSHFIKTLSALRPHSGEENKVGTAPLSSEK"
ORIGIN
        1 caatccttgc aattgttcgt tgagacacta cacgcgatac ttattcgctt tttattttat
       61 ttcgcatagt caacggcacg tgtttcacgg ataaccgtta ctttgatatg tcctggataa
      121 tccaagtcat cttcaatttt cttccgaatg tctcgaacta aacgaacaga ttctaaatca
      181 gaaatttctt ctggtttcac catgacacga acttcacgtc ctgcttgaac agcaaaactt
      241 gaatcaacgc cttcaaaact attagaaata ttttctaagt tttctaagcg gcgaatgtag
      301 ttttctaacg attcactacg tgcacctgga cgggctgcag ataacgcatc tgcggctgcc
      361 actaaaacag aaataactga ggttgcttcc acatcaccat gatgcgaggc aatggcatta
      421 ataactactg aattttcttt atatttcgca gctaattctg cgccaatctc aacgtgagaa
      481 ccttcaattt catgatccaa tgctttccca atatcatgta gtaaacctgc acgtttggct
      541 aattgaacat cttcgcctaa ttcggcggct aaaacgccag ccagttttgc tacttcgatt
      601 gagtggttca agacattttg accataactt gttctgaaac gtaaacggcc taaaatttta
      661 attaaatcag gatgtaacgt atgagcacct acttcaaagg ctgcttgttc tccgtattca
      721 cgaatccgtt catccatttc tttacgtgat ttttctacca tttcttcgat acgagcggga
      781 tgaatccgac catcttggat taatttttcc aaggtcattc gagcgatttc tcgtctgatt
      841 ggatcaaatc cggataacac aaccgcttct ggcgtatcat caatgattaa gtcaatccct
      901 gttaatgttt ccaatgtacg aatattacgt ccttcacgac caataatgcg acctttcatc
      961 tcatcatttg gtaaagtgac cacggaaaca gttgtttcag aaacagaatc ggcggcgcaa
     1021 cgttgaattg ctagggaaag caagttcttc gctttgcgat cagattcttc tttggcacgt
     1081 tgttctgact ccttgaccat caaggttagt tcatgattca actcttcttc tgttgacttc
     1141 ataataatcg attttgcttc ttcttttgaa agggaagcaa ttcgttctaa ttcttgatgt
     1201 tgctgattaa ttaagttttc tacttctttt tctcgctcat caattaattg ctgtctagca
     1261 ccaagtttct cttctttttc ttccagtgag ccttcacgtt tttcaagaga gtcatcttta
     1321 cgatccaacg tttgttcccg ttgaattaaa cgattttctt gagatttaag ttctaatctg
     1381 ctttctttca actcactttc aatttctgaa cgatacttct ggttctcttc cttagcttct
     1441 agcaatgctt cttttttcag tgtttctgat tctttccgag cgttctcgag aatactcgac
     1501 gctgaaattt ttgcaccatt tattgcttta tcatgacgtg actttgcaat aacaaatcct
     1561 aaaccaagac cgacaatcaa accgacgata gcgaggagaa tatttaaaac catatttcca
     1621 cctccatact atctttttgt taattcatat cttgtagttt tttgataaac taaaatcaat
     1681 tatcaatatg cctacttgca tatttgtgca tacacacaat tttattctaa tgtttgtcgt
     1741 gaaaggtgtc aacttaaaaa agccctttct tttggaaagg gcagcaaata ttagacaacg
     1801 tcacattttt aggtttccgc cgtcacaaat tgtttaaatt ttagaacaaa cgccgcatag
     1861 tctgctgttt gactaagctg cttgatgtgg atgggttcgg acatggacaa cagtctattt
     1921 aacaatttag ttctaaacaa agaaagacaa cacctgtcct gttcagtaag tgttgtcttt
     1981 cttcttaacg agtcgtattc actcgttatt tattcatcta agggtaattc ttcttgacct
     2041 tctgcttctt ctgtaatggt tgaaccgtca ccgatgccgt atgcatcacg gaccaattta
     2101 gacacttctg ccatcatttc aggatgatcc gccatgtatt gtttggcatt ttcacggcct
     2161 tggccaattc gttcttcttt gtagccatac caagcaccac ttttgctgat aaggtctttt
     2221 tccacagcca tatctagtaa ttcgccttct tgggaaatcc cttggccata catgatatca
     2281 acttctgcca ctttaaatgg tggcgccact ttgtttttaa cgactttaat ttttgtgcgg
     2341 ttaccgacga tgtctgttcc ttgttttaac tgttctgcac gacggacttc tagacgaacc
     2401 gttgcgtaga atttcaatgc acgtccacca ggagttgttt caggatttcc gaacatcacg
     2461 ccaacttttt cacgaatttg gttaatgaaa atagcaattg tttttgtctt attaattgag
     2521 cctgataatt tacgtagtgc ttgagacatt agtcgagctt gtaagccgac atggctcgct
     2581 cccatctcac catcaatctc tgcacgagga actaacgcag caaccgagtc gatgacaacg
     2641 atgtcaatcg caccacttga aactaaggca tcggcaatct ctaagccttg ctcacccgta
     2701 tctggttgag ataaaagtaa ttcatcaatg ttaacgccta gtttctccgc atattgagga
     2761 tccaatgcat gctcagcatc gataaaagcg gctgttccac catttcgttg cacttctgca
     2821 attgcgtgta aagaaacagt tgttttacct gaactctcag gaccatatac ttcaataatt
     2881 cggccacgtg gatacccacc tacgcccaat gcaacatcta acgctaaaga accactaggg
     2941 atagttgaaa ttttttgatc agctttttcg cctaatttca taatagaacc tttcccaaag
     3001 ttcttttcaa tttttttcag tgcggcatct aaagccactt tacgatcatc tgccaatgga
     3061 taatcctcct ttaatttata taaacttatt tttcatttcc tgttagtagg tctatcatat
     3121 ctcttttgta ccaaaaaagc aagaaaaaac cgaacaaaca ttcgcatatt tattttttat
     3181 taatgattcg gcgccgcaaa agatctaacc ctcgcataac cgcactctgt ctaatataat
     3241 ttcggtcacg gttaaaatgg aaacattctg caacggttgg ttggccttct tccgccagcc
     3301 caatccaaac agtgcctgtc ggttgacctt cgattgggtc accagcgacc ccagtaaatg
     3361 ataaaccata gttagattta gctaactgac gcgctttctc tgccatttct ttggcacacg
     3421 cttcacttac cgtgccatgt tcttctaaaa gttcatgaga aattcctaaa aagttctctt
     3481 ttgtttcttg cgaatacgtc acgaagcctc ccttaaaaat cttcgaagca cccgcaattt
     3541 cccccagtgt actttggaat aggccagcgg tgaggctctc agcagccgtg acggtttgtc
     3601 cgttttgtaa taacaaatcc actgttacct tggctaaact attgtcatcc ccatacccat
     3661 aaaaatagtc tcccacttta gctaaaacct tttcttccgt cgctgttaat aattcttcgc
     3721 cagctactaa gtcttttgtt ttaactgtta aacgaagtgt cacttcatta ggcttagcat
     3781 aaggcgcaat ggttggattc gtttggtgcg caatcaacga ttgaatctcg gtcaccagct
     3841 gtgattcacc aatgccataa aaacgcaaga ctcttgaaat caattgttct tcttgtggaa
     3901 acgcattaat caataaaggt cgtgccgctt gttggaacat cggaattaat tcattgggcg
     3961 gccctggtaa gagcaaatag cttgttgtgc cttctgttac gaaagaacca accgctaatc
     4021 ctgtcgggtt ttgaagaact tgtccacctt caatggctaa cacttgtcgt agattatttt
     4081 ccgtcattgg ccgcttagac tgttggaaaa actggtgtaa gcggttcaat ccttcttgat
     4141 cttctactaa tgatttatgg agatgttgtg cgacaacttg cttggttaaa tcgtcttctg
     4201 taggtcctag ccctccacaa aagacaatta aatcacttct ttgttctgct tctgttagta
     4261 gcgtttctaa gcggccgccg ttatcaccaa caacggtctg atagtaaaca tcgatgccta
     4321 gcgcagctaa ctcttctgat aaaaaggtgg cgttggtatt cactacttgt ccaagtaata
     4381 actctgttcc gactgcaatg atttctgctt tcattgattt ccccttctct aataacatac
     4441 gtagttaaac tcactttcca ttttagcaca acaaaatttt tacaaaagaa tttgagcttc
     4501 aggaaataat ttttctatca ggaaatttat taattattac gaaaaaaatg ttcattttct
     4561 cacaatacat tgtataataa cgttatatcg aaaggagaga aatgaatgag tgtagtatta
     4621 gtacttttgg gtctattagg gttacttgtc agcgggggtc tgactatcaa agcattaatt
     4681 aagaaacaac cgaaaaaaca atatggctat gccgcattag caagtgccgc tctatttatt
     4741 ggtggggttg ccacgacaga ttcttcccca acgctttcac ttgatgcaga gagtgttgaa
     4801 accgatgcca atggctcagc caccatcaaa ggcgaatacg acggcaacag caaactaacg
     4861 gccaatggca aggaagtaaa aacgaaagac aaaacgtttg cttacaaagt aaaactgtcc
     4921 gatgaaaaaa cgcaaaaaat cacttttgtt gctgagaaga aagataccaa agttgaaaaa
     4981 tcagtcgaag tcacaccgtc aaaagaattt attgcgagca tcacagattc tgagcaagaa
     5041 ttggccaaaa cagaaaaagc cttagcttac gctgaaaaac aaccttctca gaaaaactat
     5101 gatgaagccg caaccttagt atcttcatta agtcaagaat acgagaaata caatgatcgc
     5161 cttgaaaaaa tcaaagaagc agtacctgtt gatgaagcag ttacaactgc tgaaaaatct
     5221 aaaagtaaaa gcgattatca agcagctgaa aaattagtag ctgctgcccc agttggcaaa
     5281 gaaggatttc aacaacgatt aacgactgtt caaaccgcta tcgctgaaaa agaaaaaaat
     5341 gaacaattag tcgccagtgc aactgccgct gttgaaaaag ctgaacaaga accaagcaat
     5401 gaagcttact ataatgaagc ggtcaaacaa attgacgctt taaactcccc aaatcaagct
     5461 ttaacaaaac gggtagccgt tgttaaaact caattagatg cccacaaaga aaaacaacga
     5521 aaagaagcag aagctcagaa actagccgct gaaaaagcgc aaaaagaaca agccgaagcg
     5581 gcagcaaaag cgcaagctga agcagaggcg caacaagccg cacaggcgcc ggcggaagtc
     5641 gagacggctg ctgcggaagc accaagcggt aacgccttaa ttaaagggtc acgtaatgga
     5701 atttatcatg tacctggaag tagatattat aatagaacta cgaatccagt agcttggttc
     5761 tctactgttg aagaagcaga agcagcagga taccgagcac ccaaacagta aatacattag
     5821 caataattaa tcaaacaaaa aaaacatact aagattagag ggtgaattca tcgacgggtg
     5881 aatttaccct ctaatcttag tatgttttaa tttcttcact cattcaagtt tatagaatac
     5941 tttgttaaat agattcgttt atatgcaaaa cttaaaagtt tatagccttt cttttcatac
     6001 tattttttgt tttcagattt ttgtcactac aataaattat tctttataaa tggtgccctt
     6061 atgacctatt ggaaatattt gtatcacaac tttagaatca caaatattag ccagtattcg
     6121 atagtttcca attctatagc gctattcaac aacttctcca tttgctcttg agaaatacca
     6181 atctcttttt tctctttgga aatttccatt gcgtttcgta aggtttttaa gtcaatttca
     6241 tcatcaagaa ttctaaatgt tgttgttgat caaaacatat aactacctcc attcatactt
     6301 tatactaaaa aaatacggcc cggtcaatac atcgttagta cacataggag gagcaccccg
     6361 gaacatctgt acagaaaata gtgatagtga ttacctctaa atctgtaaaa cgtttatttg
     6421 aagcagctta tagaattttc aagatataaa acaaaatata tttctgaaac attcatacag
     6481 aaattagcat gtggtgtcca acagttgtta ttgtcgagtg ggaataaaga gccaacatga
     6541 tatggatggg gagcgcctat aaaccaacat cttccagttg ctaaagagct tgattttcat
     6601 aaaaaatgat atggtttcct atcaaaaatc ccttgcaaaa ttaacgtttg acaagggact
     6661 tttcttttgt ttgctgcttt tttaagcctt ggttgactgt tcctgaattt tatagagttg
     6721 aaaaacactg tttattggaa tttatatcaa acttttaagt aaattagctt cactatatta
     6781 tattaaatac tcgttactaa tgttcgtaac caaaataaat taattgcaca gcaaagaaca
     6841 taataaaact cgatgattac tttggcaaaa ctacattctt ttaacaagat taaattcttc
     6901 ttttctatca tacaatgcca cacattgatt aaatttataa tcatatttaa tattaagcat
     6961 attctttcta attaaattat caaagtctaa aatagttgta caagtttttt cttctccaca
     7021 tacgccacat ctatgtgtat tactttctct aatcaagtct ttgctttcat ccttatagac
     7081 tgcagcaaca gcatttattc tgttatctgc cctatcctct aaagagtatc tcaagcatta
     7141 catctcatta tataaagaat aatatacttt ttgcatttct aacaattgtt cgtgattacc
     7201 ttcctctaca actctaccct tatctaaaac aattatccta tccatatttt ttattgtatt
     7261 caacctatgt gccacaatca cactagtttt acaattattt aaaatataat ccattatttt
     7321 tttttctgat acattatcta atgagctagt cggttcatcc ataataatta catctggatt
     7381 ttttaataaa catcttgcaa tggaaatctt ctgtttttga cctccagaaa gattcattcc
     7441 attttctgat attattgtat tcaatccgag catatcatta tctaccagtt cgtttattcc
     7501 tgtagcagtc aatacttctt taacaacaat aggcgattcg tcacctacca tcaaattttc
     7561 ctctagcgta ttaccaaata ctattgaact ttgtgttaca tatccaactt tatttctcaa
     7621 actactttta tcaaaactag atatttcttc attattataa ataacctgtc cttcactagg
     7681 aataaacaat ccacaaatta gttttaagag tgtacttttt ccacttccac ttttaccaac
     7741 tattgcaact ttctctcctt tttttatttc taaattcaca cttgaaatta cattcttttc
     7801 gaattctgaa aaagaaaagt ttacattatt catttttaaa ttttcaaatc tttcaaactt
     7861 ctttttacca ttaatttcat tatagaaatc tgtgtttgtg acgtctgata tttggttaag
     7921 atatgatttc aaaattaaaa tttgagaaat agaaccaatc atcgtagaaa atggttcaat
     7981 aaaatatgct atcaaggttg taaaaccaat tagttgacct aaagacattt ggttcgcctg
     8041 aacttcatgt ataccaaaaa aaagaataat aataggtaaa gtaaaaagta gcgtagtaga
     8101 aattctggat aaccatgctg ctgcttttcc ttgttgactc aaacttttca aactgttact
     8161 aaatatgtta gaccaccttg taaaaaaaac cttctctttt cctaaggatt ttattgtttc
     8221 cattccagaa aatatttcaa catacaagga ttgaatttca ctttggtact ctataactct
     8281 tccattgatt ttataattta ttttagaata tgttagggaa ttaattaata ttaataaaca
     8341 aaatatgata gtaattattg tcaatttact tgaataatta gttaaataaa tgaaatatac
     8401 aatcataaat aaataatcta tgatattttc gattgtattt tttgaaagca tttgctgaac
     8461 catagtgatt aaattagctt tataaatcat tgaacctgat gatctgttca caaaaaaatt
     8521 taacgacttt ataaaaactt tttccataaa tttattagat aattttttac tccagctaag
     8581 ttgcaatttc gttaacaata aactataaga gactgttatc aagtaatata ttcctgctat
     8641 taaaatcgtt ccccctatta aagtagctaa agacaaattt gctaatatct gataattatc
     8701 tattaacctt tgagtcaaaa caggaactat caatgataac atcttagata aaaaaattac
     8761 aaatatcata agtataatta tcgattttgt actacgtaat agactacaaa ttaactcttt
     8821 ggtcttgttt ttcaaattta ttttaatttc tttttttcca tcattataat taatttcttt
     8881 aaacacaagc gcatataagg agaaatgttc ttcaaattcg tgttttgtgt aaacaacttt
     8941 tcctaatttt ggatccatta catagaaatg acctctttta tatttataaa aaactacaaa
     9001 atggttatta tcccaaaaaa gaataactgg ctttttttga tttttcaaat agtcagtatc
     9061 atttattttt attccatgat atattaaacc aaattttttc ataatataat tcatattccc
     9121 aaaagttaaa ccacctttag gacttccata tttatcacgt aaatcattta tagtaactct
     9181 agatccaaaa aagtttaaaa tgcttgttac tactgctata ccacattcac tatgctcgtt
     9241 ttgataaact acttttatat ttttcatgag tatttaccta tatctatcga aatattcttc
     9301 taaactatta catgaaaata acccactatt ctcccaatac ctatattctg acaacgtttc
     9361 attctgtttt gaaatagatt ttttccagtg ttgaaacgac atctccatac ttaaattagg
     9421 tgaaatcttt tgaggattac ttatatactt tagtccttct cttacagatg cttctatttc
     9481 attctcagaa ataggattac tccttattga tataatttct tgtactctaa ccattcctaa
     9541 tccatcacaa aaagatttca aatagttgga agtttgaata tgaccatttc catctgacgt
     9601 taccacagtg atacatggtt tttttgcaaa ataaaacaaa tgtgctaaat gacaaaaacg
     9661 atcaatgaaa agtttaatat ctgcagatac attagcaaaa taagttggac tcgctagaat
     9721 aacaagtgaa gcattttcta tctttgcttt tattttttta gaatcatctc tttcatcttg
     9781 ttcatttgta tctgctcctt ttataaacgc taatctaggg ctatcggaaa aatttagatt
     9841 ataatcatag ggagtaataa tttcaaactc aaaagaagca ttcaaatcct gaaccgtttc
     9901 ttttattcta tttactatgc ttagagtttc actattttta tctcttgaac cgataattgc
     9961 tagtattttt ttcataataa tctcctcata attcatattt ttaaacaaaa actgacggaa
    10021 cattctctgg ttctaatagc ctaaccaagg tatatgcaac accagatatg ccattaaata
    10081 aaccaatatt atcaaaccct tcaaactctc ttatttgtat atattcgttt ttaataattt
    10141 cagaaatcat tttgttacct attttttttg catgttccaa atatttatca gagttttcta
    10201 ataaatacaa atcaatataa aattgaatta tcccacaatt accatgacat aaacagtcag
    10261 attccaagta ttgattttta atttttaata gtaatctttg tttttcttta tcagataatg
    10321 cactcttaat attatttttg tgaaggtaag attgtcccaa tagataacct aatattccat
    10381 tacaccaaga tacaacatct tcattttcct gaactagaga aatagacatt ctttcattta
    10441 attttttaat atattctaaa tattgcctat ctttggtaac tttatatagt tcaaccatag
    10501 atataagtaa gcctgaaatg ccatgaccta taccaatatt tttcattaca tttgtatctt
    10561 tttcagcaaa cattatcaat ttgttaccca aaaaaatagc gatttctaaa tattgattat
    10621 ctttggtttt cttatacaca tcaatatata atgggattat acctccataa cctaataacc
    10681 agtctactgt accctcacgt tctaaaaaat tttgagaatt ttgctgtaac aggttcaaat
    10741 aatgtgtaat tctttcatag ttagtatctt ctttttcgat tatagaaaac aattgtaaaa
    10801 atgaatgaaa ccctacataa gcactatctg tttgcatagt atctaaaaga tccatcgtag
    10861 ttttcactaa ataatcaaaa tatctttgat attttacttt tcctgttact ttatataacg
    10921 atttaaacaa tgatgcaatt cctattaacc catcataaaa attgactttt gaagcaccta
    10981 aatcaaattc atcaactaca ccatcattta taaccaacca agtcatatat tcttcatttt
    11041 tgtcgatata agctgagtca attagttttt cagctaattt ttcagctatc tgtaggtaac
    11101 tatcctcctt acttattact aaacttgata catcttgttt tacaactccc tcttcacctt
    11161 tgattttcat cataataatc cctatctgtt tagaaatatt ttctgaatca atatttttaa
    11221 ttttatcaat taaaaatatt ctaggagtat tttcaaaaac attttgtatc ctaactcctt
    11281 ctgaattgta gatacaattc tcatctagct ttgaaaaaaa tattgggata tcatcaaaaa
    11341 ccatatcttt atactctaat tgagatatct gtttattttc ataagggaat gtatataaat
    11401 tttccaatat cttttctaac tcaacaaaat cttttaaaca gtttgggtgt ttagtaaact
    11461 ccaaaaattg agcatatgtg ttcgtatttc ttgctaatat tctaattgta ttattttcca
    11521 tgccttcaat tagattcaga tattcttctt tattaaccaa aaagaagtcc attacattac
    11581 taaaaccagc aataatttct ttatagtaat cttgatagtt aataagttta tccttataga
    11641 acacattatt attactgcct tctaaaatga cattctctaa tacaaatttt gcattatcat
    11701 tgtctaaatt ttttggaacg tacatttttt tttctaattt ttgagttttc ccactaagcc
    11761 cactaatatc aacgctattt ccttctgaat ctaattgcat tttccccggt agcataatac
    11821 tagacgatac agaatttcta ataaacccca caatttcact gaatatattt tcttgtcttc
    11881 cttcaagttt tataggaacc gaaaacaaag tttcatagtc aactataaca ggatactctc
    11941 catgagaaat tacattttca aaatgaatat cactaccatt agttaaatag attaatgcaa
    12001 ttagctgacc atatcgttga taaaatcttt caatttcttc ttcattatta caaggttctt
    12061 gctcgataaa ttgaacaaaa gtgaatgtag aattatacaa agattttggg atatccatat
    12121 ttaaaaatcc attactataa gaaaagaact ttataatttt ctgaaaattc ttttctatat
    12181 ataagtttct gggtttataa acaatttttc ccaaattaaa ctctataata acaacacttt
    12241 tccctttttc atgagtatcg cctttttcaa atatcaaact ttctacatat attttttctt
    12301 ctgtatcgaa gaatgtatct tcaattgaat cccatgattg aaataaatta ttcagaaatt
    12361 cattcatgaa atcaataaaa tataaggttg ttatactcaa ttttcttgtc attactggat
    12421 atttttgata cagattcaac aatttttctt tatcatcata caaatctata aaatttataa
    12481 atctttcttt tgatgtttca ccatgaagtc cattgctatt tttaataaaa tccatttcta
    12541 acacaaagac ttttaaactt agatttatta atcgactagc taaacaatcg aaaatatttt
    12601 ctatagcttt ttccgataat ttatcctgaa aatcaacaat taagccgttc tctagttttg
    12661 ttaaaaatgg tctgattaat ttaacatagg tactaggtaa gttattttga tcctctatag
    12721 atgctatcaa gctatcgaaa tcagagtacg tcactctgtc actgtaagaa tctattttaa
    12781 aattttcgtc tatacaatgg ttaaattcct ctagtttcca attattgata tttagaatct
    12841 tactgaaaag ttcactatcc acagttgttt ttctattaag ccatctttga atgttgctac
    12901 tatttttatc atcaaatatt ttgttcttaa ttaaactcat tctttcctct atagttaatg
    12961 ctttcccctt gtcaaaacag ttcataaatc cccctcctaa agtattatgt atataattat
    13021 tgttttaaaa aatgtatgga attaaattcg ttgaatttaa ttccatacat ttcaaattcc
    13081 aacaaataga atgaaacata tatttttatt tctacttatc aattaaaaac actttattat
    13141 ctgcactttg taaaagcaga caatgtatac gatcctacga atgaacttgc agcacttgct
    13201 acagtggcag cagaaagaat aattgtaggt gaaattctag cgttatcgtt tccaccagca
    13261 ataaagttca tttcttcttt tgataaatct tcaaattttt gacctactaa cgagtctaat
    13321 tgtttttcat ccaatataat ctctcccttt catattaaaa acatttttta gtatatgaga
    13381 caagaccact aacagctgac aaagctgcag agccagccgc tgatgcaaca taacttgtgt
    13441 atggtgtgac aggagtaaca atagtcggag aaattctagc gttattattt cctccagcaa
    13501 taaagttcat ctcttctttg gataaatctt caaattgcat accaacaatt ttttctgctt
    13561 ccataataca atcccttcct ttcaaaaatt atatagcgtg ttaacacatc ttcatgttat
    13621 catgataata taaaaaataa agtaccattt gttatacatt ttacatatgc aaaacatatt
    13681 atacaaatgg ttaattcttt tatcaacgga ggtttttatg aatactggag aaaaaattcg
    13741 aaaatataga atggaaaaaa atctgtctca agttgaactt tcatcaatac tattagtttc
    13801 tagacaaaca atttcgaact gggagaatgg acgaactaga ccagaaatgg aaaatttagt
    13861 actaatcagt aatttttttg atgtaccatt agaggttttt ctatcagaag atatctcaga
    13921 aattaaaaag caacacaccg aatttacatt tacagctaaa attatattta taatttttat
    13981 ttcaatttgt gtattgattt caagtatttt catgtctata aaaatgagta aatattttct
    14041 tgtttttcct tttttgctat taaatataat ttttgcctgt ctattaacat tttttcttag
    14101 gcaaacacca gagaaatctt atttaaaaaa attcaacaag ttgaacttct tatttattat
    14161 tctcatcatg ggtttgatta gttttttctc tatttatttc ttgctaactc ttttaaatta
    14221 aaatgtaaaa aacctttata gtctttacta aataaaacta ttacgctatt aatccttctt
    14281 atttttgtat atgctacact tgtaacgtat atattattat ctgaaaggag caattgaaat
    14341 gagtaacgaa gtaaaaaaaa tgatttcttt aacttggatt ttatttttag tatccatcgt
    14401 aacaatgatt tccattggta ttacttttaa attttggggg ttgaaaggat tattgatacc
    14461 tgtttttgaa tgtagtttaa tagcatatat aggtttcaaa attgaaataa taagaagaag
    14521 aatcaacatt aagtcctaca atgaattgct aaatattcta cattatgatt ctctgaaatc
    14581 tacaacttca ccctcaagaa aaaatttttt ccttgaaaaa aacctgcttg cttttctaat
    14641 ctcttttgtc tttttcctat taatcatttc gataagcttt gtaatatttt gataaaatta
    14701 aaatagataa ttgttttgtc gatttatttt taatgatctt aatctgactt actgtttttt
    14761 tgtcaggtca agatcgttta cacgtataat ttacaaaaaa gtgattttac tgtagctgta
    14821 tcaatttcct ttttagctgg cggtgctttt gccccgataa atagcggtgt caataaatat
    14881 tgacatgaaa ctaaaattaa atatatctaa aatactaaac cacttttata gtcaaaatct
    14941 attcagtgtc aagggccata taaagatgta tgttttggct ctctgctatt tttcaatatc
    15001 gaggcccttc gtttccatgt aatctttcat tcgataagat ttctcattga ttgataaaat
    15061 tttagaatga tggattagat gatcaataat cacattcttt accttttatc ctggaatacc
    15121 tctgtccatt ggaacagagc tatattggat gttagaaccg ttgatttttt ctcataacgt
    15181 aagttaatga gctggaaaaa gaaattcgcc ctatttttta tacgacaact tcactctaaa
    15241 aacaaaaaag actaccttca cttagttacg tagtcaaaca atattgatat atcccatatt
    15301 aatcattctc ggttactatg gtctttttat tttgtaaata ctttttatac gcagattcta
    15361 tgagctaatg tttgatacaa ataagtataa tgatttagtt tgtccctcaa ggtaacttgg
    15421 aaaagaaact cgattattaa tcgacctaca aaccacttct gacagtttta atatgacaga
    15481 aaaattgttt gtaggtcgat tgttttcatt gtagttggtg agggcgggtt agacctcatt
    15541 gacgtttgtc cagactctgc tagataggta ttttatgcca acgaaagtaa agcttgtgct
    15601 ttcgttaaag ctttttgagc ggagcttttt taacggcata actttttccc attgagacat
    15661 ctaaagcaag tacatacatg attttcatct cctacacacg gtctcgaagc ctaccatact
    15721 taaaccagat tttaaatgac agtgaaggag atcatttttt gtttgtactc acagtcctag
    15781 agagtgtggt cggtcttcct tttacaacca actatacgct taaaacagcc ctagaggata
    15841 cctctaatct tagtatattt tttgtattaa taattttttc ttttattgat acacactaat
    15901 tcgttgattt gggtgtgcat tactttccac ttcatctaac atggcaacgg cgtagtctgc
    15961 gtaactaatg tagctgtcac cttgactatt ggttgttaat tcttcgccag cgacttcata
    16021 atggcctgtc gcaggacctt cagcatcaaa catggatgca ggactaatat aggtccagtg
    16081 gatgttttga gcttctttca ataagtttaa agcttcgccc atcgccgaag ctaatggctg
    16141 aatttctgct gggaatgatg gtgtatcttt taattgagtt gtgtgttctg ggtccacata
    16201 caaggttcca gcgcccccaa cgacaaacaa gcgcgttttt tgattggtta aaatctcaat
    16261 caaatgctgg gtagattttg ggaaatcttg cacatcaggg aatcctaagg cactaattaa
    16321 tacatcaaac gcttgaatat cttctgttgt taattgataa acatcttttt caatggtcgg
    16381 tgtgccatct gttatttttg aggcattacg aacgatggct gtcacgtcca tcccacgacg
    16441 tttagcttct gctaaaagta attgtccttc ttttcctgtt gctcctaata ctgctacttt
    16501 catgtaaatc atcctttcat ttttaaatag aactaaaata gttacattta atactttaaa
    16561 agtagagaga ttacttatct ctcttaactt ctatttcatg aatcacatct gctaaggtga
    16621 tgcttttcaa ttcttcttcc attttttgtt gcactttagt aaattcagtt tctagtaccg
    16681 attggatatt tgccccaacg gaacagtttg gattaggatt ttgatggata ttgaaaatct
    16741 ctcgttccaa ttcaaccgct gtataaattt catacagtga gatctcttct ggtttcttta
    16801 ataaggtatt tttattggct ccacgcatgg aatgaatcaa gccggctttt tttaactggc
    16861 tcattagtcg tcgaacaacg actggattcg tattcacgct cgaagcaatg tattcagaag
    16921 tcacttgttc ttgaggacct gtttcaatca aacttaaaat atgaatcgca acacttaatt
    16981 tcgttgacat ggccatgtct aatcactcca aactaaatgt aacgttattt gttacattta
    17041 cagaatacgc tgtttcgttt tatttgtcaa tgagaaacct ctgactattc aaaataaaaa
    17101 tcagttgttg aaacaacacg ggccccaaac ggcattaacg ctaatttcgc caatttaaag
    17161 gactgttgcc caaacggaat accgatgatt gtcagacaaa gcaacaagcc actaatacaa
    17221 tgcccaattg ctaatggtag tccactgata atcagccaaa taatatttac caccaaagat
    17281 acgccgctat cactatacac gactcgcttt ttaaacggcc aaaagctcaa ccccgctaat
    17341 ttaaaacatt gtaaaccaat cggaataccg ataattgtaa tacaccaaat cacgcctgcg
    17401 aatagccaag ataagccacc aaaaaagccg ccaaagatga accataaaat attgccaagt
    17461 gttttcattc ttgttcctct actttcctca ttaaaaatta tgtatgtgag taagtatacc
    17521 acgaaagctt ctttttgttt caaacaatat tgtaaggtcg ctgactcgtt aaaagacgaa
    17581 gacgctgttt catgatacaa tgaagaaact aacgataaag gagcagactt catggactta
    17641 catttaaccg ttgatctaaa aaaaacaaag acactcattg acttagccga tcaggcccac
    17701 ttaatcattg aacaaacaac taaattaccg aaaaaagagg cagcgattct tttcttgcta
    17761 agagataacc aactagttgc tttaggactt gctgaagaaa aagctacata taaagaagtt
    17821 tcttttgatc actcgatttt attgaaaccg acttgggaca cagaacttgc ctatttagcg
    17881 caagctttcc tagatgatgc gaaagaaagt ggtttaacat tggaagcaac cccaacgaca
    17941 gtcaaaattc cgaaaagtgc ggtagcgaca gtgactaact ataaagaaac agtcaccttt
    18001 atcttggaac gttttggcta ctctctgttt aataaaccgg cgccgaagaa agccagacca
    18061 gccaaagcac gccacaaatg gacaaaagaa gttagccaaa ttccttttta tattgatact
    18121 cgacaaagta aagcaactgt tttttggcaa aagcgcaatg aaatgcttat taaagctggc
    18181 gcgacaatga tgccagaagc ccctttaaat aaagacgggt ctgtcggttt ctccgccaga
    18241 tttggtgaaa aacttcgtga tgaacgcaag ggccaattta aagactttgt cacaacggaa
    18301 gatatcgtct taaaaagcgt taatgaagtc ggcttgtttc tctattttgc tggaacaaac
    18361 agctggttag agctagttga tgagaacggc aaaactttaa atgaatggac tgtggtggaa
    18421 taaaccttat aaaaaatgtc gcacctgatt tttatgattc aggcgcgaca tttttttaat
    18481 ttaaataact ttttgctatc gcttgatact tatcaatcat atctaaataa ttatcaattt
    18541 cgacatattc gtcgacttgg tgtgcagtag tggtcacacc tggtccaaag acaacgcaat
    18601 caaatgtatt gtctgattta gtaaattcag ctaagtctgt ggtcccagcg cttgtcacta
    18661 atggtaatgg ttgatcaaat tgggcttgaa tggcttgaat taacgcagaa tctttctcag
    18721 cttttacagg aattttattg taatcaatcg ttaattctaa ctgatgtttt tcttttttgt
    18781 tcaattcatc gacaattttt tgtaataatg caatgacttg gtcgttgctg aattctggaa
    18841 ttgaacggat attcccttgc aaggctgctt gacctggaat actgttcact tgtgtgccac
    18901 ctttaatgac ggttacattg tgaatcgttc gacctaattc aggattttca tagtttgctg
    18961 tgacttccgc catttgttgg tttgcttctg taataaattc gttcaaatta ttaatcgcgt
    19021 taatgccttc ttctggcatc gaactgtggg cttcttttcc gtgtgacaca acagaatagt
    19081 taattgaacc catgtgcgca tacatcaagt tataattggt tggttctcca atgactaagg
    19141 cacttaaatc atccgcatag cctttttcag ttaattggcc agcacctagc tcaccgactt
    19201 cttcaccaac tgtacctaaa aatttaaccg ctccctttaa tggaacttcc ttttctttta
    19261 attcaatcat tgctaaaacc attgcgacta agccgctttt catgtccgtt gcgccacggc
    19321 catacaattt atttccttca atatgggccg caaatggcgg gaaagtccat tgactttcgt
    19381 ccccttcaga aaccacgtcc atgtggccac taaaccctaa gactttttct cggttttcac
    19441 ctaggtaagc aaccaaacta ctacgatttg gtgcataaga aacaagttca gaagggatct
    19501 catatttctt caaaagattt tgtaaataga ttgccacttc ttcttcgttt ccatttacag
    19561 atttaatttt aaccacatct tgtaaaatac taattttttc tgatttttcc attgccattc
    19621 gccctttctt gttatgctta attctagtgt acgcttctct cagtaaaacc gcaactgact
    19681 tggttaggtc agttaaaaac acgcgacatt tcttaaaact gtcgcgtgtt ttttgctgag
    19741 tttattttaa ataattaggc gctgccaatt cattctcaat gacttgatta gggatcacaa
    19801 attcaggggt gcccatatag taaggcgcaa tctctccttg aggaaacaca atcactaatt
    19861 ggtgtttttc attgatatag aaaggttggt cctttttaat ttttttgaag ggttgaacat
    19921 cactgggggc atcctctttt tcggaccagt atattttatt gctatcgttc ttcatttggt
    19981 ctgctatttg ttgtttaatt tcactactaa tgacatcaat gtaaaaatca tttttaaaaa
    20041 ttaaggggag tgaaacgaca acattggctc gtttgtcgat ggtgtcatat ttcgttgtcg
    20101 tcgcagagct gcctttaatt tctgtgaagg ttcgtttgac cactaggaaa cgacggtcgt
    20161 ccacgacttt ttcataatct ccagtgactg aaacacgaga accatcaaac aattgccctt
    20221 tgacttgttg aaattctgtt tgggcttctt tcaagtattt tttgttgagc gtgtcggcta
    20281 ctgaagattc ttgggatgtt tggattttag ggacatcgat gtttacttca ctttcctgtt
    20341 ttttcgctgt caacgttttg atggtgacta attgaacaat tttatctaac acaggaatgt
    20401 tgcgggctgc ttcactaaaa cctggaaaca aattgactga taagacaaag ccacaagcca
    20461 ccactagact actttgcagt gagcggtttc taaaacgaag ccaggtgtac cgctttttct
    20521 ctttatgaaa acgcgctttg acttccgctt gtagatccgt tggcaacggt tgttggcggt
    20581 attcttttga aaagttttta acaacgcttt ttacaaaatc ttccattatt ttttcgcttc
    20641 ctttctttta ctaattcaat agacttcgga gttcattcaa actgcggtac atcttcgttt
    20701 taatcgtgtt ttcgttaata tccaggatca aggcgatttc ttttagcgta aatccttcaa
    20761 aaaattttaa tagaataatt tcacgattgg gactatctaa ttgattaata atttcttcaa
    20821 tttctaaaaa actgcgttgg ggattattta aaagggctaa cacatgttca tctttttcaa
    20881 tatgaacggc ttctcgtttc tttttacgcc aataatctgt cgctacagaa agcagaattc
    20941 gaaagaacca cgcgtcaaaa tccttaatat cgggtccttt ttggatggcc ttcagtgcct
    21001 tttcaaagct ttcttgaatc acatccaagg catcttcttt cgaatgtgta tagttaaagg
    21061 caatgcgata cattttttca tatttggtat caacaagcgt ttctaacgcg cgaatttgtt
    21121 tttttctttt ccaaccatcg aaaaccatcg atttctggaa cctcctttcc tgtacactta
    21181 tatagacgaa tcacaagcat aaaaagtttc aactttttta ttatttttaa tttttatatt
    21241 ctaaaagaaa aagcgcggta caaaaatcac tttggatttt tgctccacgc tcaaaatctg
    21301 ataaacggcg ggaacagaac cagctccttc ggaaataagc cgaaattatc caaaaattaa
    21361 agaacaattt ccggaaattt cttcttattt ctcggagcta agcggtgctg tcccgacctt
    21421 gttttcttct cccgagtgcg gtcttagtgc actcagcgtt ttaataaaat gcgaccaatc
    21481 aacaggacgt ggtggcgcta gccaaataat ttgagtaatc tcaggccaat cgacaaaatg
    21541 aatatccgat aaaattaatt gtacactttc atctacatgt gctttgaaaa tgatattcca
    21601 ttccgtaatt ttttcaatat ttttttgtat catacgatta taggcttcac caaaggaaaa
    21661 gtcgacacac aatgtaatcg gagccaaaac ttttttcaat ggtaacgcat ccaccattaa
    21721 caacagatac cgataaaata aaaactgtct ggcatcccaa acagcgggat tcgttttttg
    21781 ttcttgaata aattgtcgac tagcagaaaa atactctgta tacgtttctg caaagtaggt
    21841 tatatccatt ttgcgataac tatagtttgc ttctattgga aaatggaaca atttaaaatg
    21901 aacgattgtt actttttgtt caaaacctcg caggacttcc tcggaaagct gaaattgtat
    21961 ttttaaatag cttaacaagt cacgattcaa ttgttgaatt tctgcaaatc tttggcaaag
    22021 tgctgctgaa gctacttgaa gccactcttc agcaattaaa aataagagta aataattgcc
    22081 ttcgtttatt cgttgtggtt ctgggacttg aagactctct aaccaattga aaacattctg
    22141 ctgattgtca ccggctaatt gttttaacac ttgcgaatct acttttttct ctacataaaa
    22201 ctgttgctgc gttcgtacta aagaaaccgc caaaaaatga aaacatttag cttgtgcata
    22261 gcccgcacgt tgattaagat gtaccttctc agaaaaaaat agctcaaagt tccgaatctg
    22321 ctctaaaact tttttaccgt acaatgaaaa atcacgttgg tataattgta aaaaaaccag
    22381 tgttgttact tcgcgtaaat tggtttcatt tcccaccaag tgaaattctt tattaattgt
    22441 aatttgataa ttttccagca ttttctttaa ttccttgaac tccttataag ccaatgtgtg
    22501 actaacaaag tgttctaaag caaactcatt cacagaatca aaacgctgaa aaaagaaatc
    22561 ttgaaacata gcaaaacgta acgactcttt aatatagcaa tcaatcaaag tatcggaagt
    22621 ttccgttcct gattcattaa gagttaagaa aataccatcg ctcacaattt gaaaatcctc
    22681 tgataaacca aattcaataa aatcggcatt taattcagcg accgttttgt tcacgataaa
    22741 ttcagataat tctaactcct gcattacagt ttcttttgac tctgttaaca tcggtgcatt
    22801 ttccagtaac tgaaataagg cgatttttct tttatcaact ttatttaaaa acatcatcaa
    22861 tatcatagac ttctctcaca tccatttttt tcccatacaa tccatttcct gaaagaaagt
    22921 acccaaccgc tgctaaatag ctttcagatt cttcatcgcc gcctgcacca agtccgttag
    22981 gaaag
//
