LOCUS       NZ_KB913032            21095 bp    DNA     linear   CON 28-APR-2024
DEFINITION  Amycolatopsis alba DSM 44262 scaffold1, whole genome shotgun
            sequence.
ACCESSION   NZ_KB913032
VERSION     NZ_KB913032.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Amycolatopsis alba DSM 44262
  ORGANISM  Amycolatopsis alba DSM 44262
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9811274)
  AUTHORS   Klenk,H.-P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Amycolatopsis alba DSM 44262
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: India
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 44262
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v. 4.24
            finishing_strategy                :: Missing
            environment                       :: Soil
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi10729
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2011
            Isolation Site                    :: Soil
            Cell Shape                        :: Filament-shaped
            Motility                          :: Nonmotile
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram+
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v.
            4.24
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina GAii
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000384215.1-RS_2024_04_28
            Annotation Date                   :: 04/28/2024 01:36:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,988
            CDSs (total)                      :: 8,922
            Genes (coding)                    :: 8,855
            CDSs (with protein)               :: 8,855
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 24 of 67
            Pseudo Genes (incomplete)         :: 49 of 67
            Pseudo Genes (internal stop)      :: 4 of 67
            Pseudo Genes (multiple problems)  :: 10 of 67
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7094977
            Orig. end                         :: 7116072
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB913032.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 404842
            Source DNA and Organism available from Hans-Peter  Klenk
            (hpk@dsmz.de)
            Source DNA available from Hans-Peter  Klenk (hpk@dsmz.de)
            Organism available from Hans-Peter  Klenk (hpk@dsmz.de)
            Contacts: Hans-Peter  Klenk (hpk@dsmz.de)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21095
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="30"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21095
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21095
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11095](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11095)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            744..2831
                     /locus_tag="AMYAL_RS0133405"
     CDS             744..2831
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159734.1"
                     /locus_tag="AMYAL_RS0133405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FUSC family protein"
                     /protein_id="WP_020635646.1"
                     /transl_table=11
                     /translation="MISRITQATTDRLVASDPGLVRLRLAFSAVLSIVVAVLAILPFHQ
                     PLTVTLVAAIAAMTSAFTVNDTTTGQQAVTLLLGLVLGAASLTAASVGSAVPPLDSVVF
                     VLLIFVAVYAQRFGSRGIALGSLSFFLFFFAMFLQTHLKQVPVLLLALTIGIAANAVVR
                     FVLVRKRTDAEFLRIRRAFRARLAAVVRAAEDHLAVGGSERTRKRLRTTNSRMHESVLL
                     IEDTAPEVAGAESANRLRRRAIEVELAVQWLTITVQRTCAEDLDEDVRDDLIARMRRFR
                     SLIERDPRELPLISETEEFSKMLVEGSRIDEHAAPGDGVRRALAELALADVRAQRVAEH
                     DVSDTADDPEDPDEEKSAAFAYDNQTRSAIQAVVGGGLAVLGGELVSSQRWYWAVLTVF
                     VVFIGSSTAGATFVKGVRRLGGTLIGIVGGLVLTLVVSGSVPATLALILVCVFGMVYMA
                     RVSQVIMAFFITSMLGLLYSLLGTFSLEVLWIRVAETAVGAAAGVLAAVVIVPVRTRAV
                     MLDDVSALLDELDEFVEKAAGLLSGAENVSVIEKSRDLDRAVDKVRTTIEPLTHPVNLS
                     SRRDYGWHVLTTVETIAFRARHVAARSQAGLLVNEADRLLLYTGRIRENIVVLGKAIGD
                     PGGSGHGTLVRDDGTPVADRIDDPRARSVLTSLGHLDETVIALGRAFGVEATDPAPSGK
                     G"
     gene            complement(2872..3516)
                     /locus_tag="AMYAL_RS0133410"
     CDS             complement(2872..3516)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159732.1"
                     /locus_tag="AMYAL_RS0133410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4360 domain-containing protein"
                     /protein_id="WP_020635647.1"
                     /transl_table=11
                     /translation="MLNVLVAAVTLLSSVVTPSGWVPPPLPSDKIVIDVVTIIGTGCRP
                     GTAAISVSPDNTAFTVTYSEYTAQVGLGAKPTDLRKNCQLNLYVHVPQGFTYGIAGTDY
                     RGFASLAAGATGLERANYYFQGNSPTANVNHTLKGPLEDNWQFTDNIEVGAIVYKPCGE
                     DRNFNINTELRAAVGTSDPKKTTSFVTMDSTDGSIKTTYHFSWKTCPKPKN"
     gene            complement(3796..4434)
                     /locus_tag="AMYAL_RS0133415"
     CDS             complement(3796..4434)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659435.1"
                     /locus_tag="AMYAL_RS0133415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4360 domain-containing protein"
                     /protein_id="WP_026467654.1"
                     /transl_table=11
                     /translation="MLNAVVAAVSLFSTILTPNSWAPPGPPPDRVVIDVVTVNGSGCPP
                     GSSAVAVARDNSAFTVTYSEYTAQVGVGAKPTDFRKNCQLNLNIHVPQGFTYGIASADY
                     RGFAALEPGAKGLQRANYYFQGNSPTAQVSHPINGPLSDNWQFRDEAEGGVIIYKPCGE
                     DRNLNVNTELRVAAGSSDPRKTTSFITMDSTDGAFHTTYHFSWKVCPGS"
     misc_feature    complement(4387..4389)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4394..4408)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    complement(4571..4582)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            complement(4690..5553)
                     /locus_tag="AMYAL_RS0133420"
     CDS             complement(4690..5553)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159724.1"
                     /locus_tag="AMYAL_RS0133420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_020635649.1"
                     /transl_table=11
                     /translation="MRISVSVTDFSWPGGQAALVDNLAEVARVADTTGLDTLWVADHLL
                     QTAPGSDPDSEMLEAYTTLGFLASETSRIKLGTMVSAATFRAPALLVKAVTTLDVLSRG
                     RAWLGIGAGYQEDEARAMGLSLPPVAERFERLEETLRIARRMWDGNSSAFTGRHYRLER
                     PVNNPLPVRRPRVLIGGTGPKRTLRLVAEYADACNLFDVPDGGKTVRGHLDVLARHCAD
                     VGRPVEEIEKTIATRLAPGESSKDLAGRCAEFASWGLDHVVVITAGPWRPEAVAVLGEA
                     VGLIAA"
     misc_feature    complement(4813..4815)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5531..5543
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     misc_feature    complement(5536..5554)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.64"
                     /tool="antismash"
     misc_feature    complement(5539..5554)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.5"
                     /tool="antismash"
     gene            complement(5676..6080)
                     /locus_tag="AMYAL_RS0133425"
     CDS             complement(5676..6080)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159722.1"
                     /locus_tag="AMYAL_RS0133425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_020635650.1"
                     /transl_table=11
                     /translation="MRSTENEIRELGARWADAEVRGDTEALDRMTAADFTLVGPLGFVL
                     GKPQWLQRYRGGDLITEKLDWAEVEIRDYRAAAVSVGVHAQEGTHQGNRVDGRFRVTHV
                     FVRDGERWLIAGIHLSPIAGPPPFARPEAP"
     gene            6172..6660
                     /locus_tag="AMYAL_RS0133430"
     CDS             6172..6660
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159720.1"
                     /locus_tag="AMYAL_RS0133430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_020635651.1"
                     /transl_table=11
                     /translation="MQKPTTAPIGVVLAKTAKTVGRAFDQALATDGGSQPVWQILITLK
                     TRRVANQRELAAAVGIQGATLTHHLNAMESAGLITRRRDPDNRRVHVVELTDEGETVFH
                     RLAKAAIAHDKRIRAGFSDEEITTLAGLLSRLAANVAGGGIDQENSDWTHPNGDSGQD"
     gene            6705..7694
                     /locus_tag="AMYAL_RS0133435"
     CDS             6705..7694
                     /EC_number="1.1.1.37"
                     /GO_function="GO:0016615 - malate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006108 - malate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009946856.1"
                     /locus_tag="AMYAL_RS0133435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malate dehydrogenase"
                     /protein_id="WP_020635652.1"
                     /transl_table=11
                     /translation="MTQAPVNVTVTGAAGQIGYALLFRIASGQLLGPDTPVKLRLLEIP
                     QAVKAAEGTAMELEDGAFPLLSGIDIFDDPKQAFEGANVALLVGARPRAKGMERGDLLE
                     ANGGIFKPQGEAINAGAASDIKVLVVGNPANTNALIAQAHAPDVPADRFTAMTRLDHNR
                     ALAQLSKKLGVPVTELKKVAIWGNHSATQYPSIAHAEVSGKPATEVITDQQWLAEDFIP
                     TVAKRGAAIIEARGLSSAASAASAAIDHVHTWVNGTPEGDWTSAAVVSDGSYGVPEGLI
                     SSFPVTAANGEYKIVQGLEIDDFSRARIDASVNELAEERDAVKKLGLI"
     gene            complement(7752..8111)
                     /locus_tag="AMYAL_RS0133440"
     CDS             complement(7752..8111)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017984593.1"
                     /locus_tag="AMYAL_RS0133440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_020635653.1"
                     /transl_table=11
                     /translation="MRIGELARRTGVSERALRYYEEQGLLTPQRRPSGYRVYGDADVAA
                     VRRIRILLGAGLNTAQILEILPCIIDEDGWLTPDCPELVDALRQQRNRIDEAIGELEST
                     RANLDTIIGADRRAS"
     gene            8164..9000
                     /locus_tag="AMYAL_RS0133445"
     CDS             8164..9000
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100: 3-hydroxyisobutyrate dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159713.1"
                     /locus_tag="AMYAL_RS0133445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-binding domain-containing protein"
                     /protein_id="WP_020635654.1"
                     /transl_table=11
                     /translation="MTTVTVLGLGPMGHALAAALTAARHPTTVWNRTPGKENGLDATVA
                     GTAAEAIAASPLVIVCVRDYAVAQSILDAEALKGRTLVNLSGGSPRQARAMADWAAGNG
                     IDYLDGVIMATTDAIGGPDAALFFSGPADVYETHRSTLAALGENARFVGDSAGRAAAFD
                     ASLQDMLWTSMSGVVHMFALAKAEGIAAADIAGEAKALLGFFPDMIDVLAEQVGSDRYP
                     GEYGTIGSAAATMDHVLDAIRARDLDNGVLSAARAEAQRAIDAGHGEDGFGRLAAP"
     misc_feature    complement(9021..9036)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            9122..10000
                     /locus_tag="AMYAL_RS0133450"
     CDS             9122..10000
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164754.1"
                     /locus_tag="AMYAL_RS0133450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_020635655.1"
                     /transl_table=11
                     /translation="MPSSPAPGSDRARLAMKLRELRAATGMSGNQFAKELGWPQSRVSK
                     IETAAQFPTGDDIVAWLGTAGARGEENVVTELLRRARVESVSVRQEFGKAGGAGATQRS
                     VHEQERQAARVATFQPAMLPGLLQTPAFMRSLLSLPSGPAQMGNASSADIEQLVAARIE
                     RQSLLYQGDKDLPFVIGEAALWIRVGDLETQLGQLDRLQSLAGLHTVDLRILPFGKATP
                     IAPLHGFRIIDAEFVAVETFTGEHQLRDPDEIALYRQLFRLLHEEAVGEEEAAGLIRRV
                     SRRLVTEDPDG"
     gene            complement(10001..11095)
                     /locus_tag="AMYAL_RS0133455"
     CDS             complement(10001..11095)
                     /GO_function="GO:0008641 - ubiquitin-like modifier
                     activating enzyme activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003082534.1"
                     /locus_tag="AMYAL_RS0133455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_020635656.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.6e-19,
                     bitscore: 68.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 8.4e-48, bitscore: 161.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPRVKGEHRPVRFGDGIRIGGKVFGIAAELKDPDGAVWALLACL
                     DGTRTVGQVVADLTRRFPSCSAEEAADAIERLVELGYVEDADEPECTALSARQRERHSR
                     GRSLYRWIDLKRRISSWDFQVRLAEARVVVVGVGGVGCTAALGLCMSGVGRLHCVDPDV
                     VELSNLSRQILYTERDLGRLKVEVAVDRLRAVNSDIEVTGEATRIKDVASLRRLAADCD
                     VLVMVADQPSELRAWTNEACVSTGTPWVHGGYHGPQVNVGIYRPGAGPCYECARLAEQD
                     REALRPPLETWRTPTEVPVNAANAVTAGVVGNLVAHAAMRLITDAPMLRLNCQYGFSLA
                     TMDHSFITGLDESHAECRACRMAG"
     aSDomain        complement(10826..11095)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMYAL_RS0133455_Pantocin_Microcin_RRE
                     .1"
                     /evalue="4.90E-22"
                     /identifier="RREFam017.1"
                     /label="AMYAL_RS0133455"
                     /locus_tag="AMYAL_RS0133455"
                     /protein_end="90"
                     /protein_start="0"
                     /score="68.9"
                     /tool="antismash"
                     /translation="MRPRVKGEHRPVRFGDGIRIGGKVFGIAAELKDPDGAVWALLACL
                     DGTRTVGQVVADLTRRFPSCSAEEAADAIERLVELGYVEDADEPE"
     misc_feature    complement(11256..11271)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    complement(11257..11271)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.07"
                     /tool="antismash"
     gene            11364..12233
                     /locus_tag="AMYAL_RS0133465"
     CDS             11364..12233
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164759.1"
                     /locus_tag="AMYAL_RS0133465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_020635658.1"
                     /transl_table=11
                     /translation="MSTLNPTAVKRWIALEMKRLREAAGYDRATAAERIGKATTVIAHI
                     ETARNLPAPADLEILLAFYGAPEKVEFFRDMTRRAKRGRDWWIKFNRAVPEWLNLYLGL
                     ETGAARINTVDLIALPGLFQTRAYARAIMLEGRKWSSEAELDAMVDLRMARQEILERTE
                     DAPQIWSILDESVLRRQIGGPAVMREQLQHLIDLSERPKIDIQVLPFSAGAHGASDGMF
                     IILTYPPEFRGDPGTVYVENRREGLYYESAAALLDFRNTFERLQVQAENPERSRALIRD
                     CAREIDVH"
     gene            12223..12453
                     /locus_tag="AMYAL_RS0133470"
     CDS             12223..12453
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164761.1"
                     /locus_tag="AMYAL_RS0133470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_026467655.1"
                     /transl_table=11
                     /translation="MSTDSPRPTLTTVSGWWKSSYSNGASGCVEFNASMPGYVGVRDSK
                     LGEKSPVLVFTPHEIQAFLTTLTNGTGPRCP"
     gene            12555..15002
                     /locus_tag="AMYAL_RS0133475"
     CDS             12555..15002
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164751.1"
                     /locus_tag="AMYAL_RS0133475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6493 family protein"
                     /protein_id="WP_020635660.1"
                     /transl_table=11
                     /translation="MHLDAILTGQPSEVLSRIFGLSPAERKALIPDLMAAFKDSREFIE
                     IEPDTYGVRNPLKGQQAATALLAILPTSDPLLRKLWIATPTILERVLQDRPLAERKAMA
                     LRLIGHQTAWEAIRRMTLDGDLEPIRTPEYHAGWFRWAGRFGGKPLAERLRTEPEALTE
                     LWELLTLEGNGDASFAAFDKYVRDEDKWSTALLELTATGELDRTRLLDLTLDVLARDFA
                     AFRAQWYAALHEALAPTPDERTTAQIRYARLCGSSLPRTVSFAVKALSLVDKQGTLDDE
                     IALQHLPAAAAGRGATTAKLALKLAGRIADRRPELTDIANEVFEAALTHEASDVRALAT
                     ARLGVTPETPDVIDTAEYPEPTRPPWDQRKTLTIPLDVPDTPAAIAEALSSLLADPDQA
                     DLLLAVLDGAHRVTGELQDALKPLVKRATKIAGEKHAAAVPKLVATLVLGLSGRDVACP
                     PQVEGWRRPLHHRVNALLDGTARPVSAATHQGGWLDPVVFVSRMLEHPEAPEDDVADAL
                     LRLAPDTRPEARSLASALTGPHADCIRYALGGPPIGDTGWTALAAARARYPESADPAAA
                     LRGDPGPPFTWTAKIGLNQYGLTSLDIDETPEAVSPKAPWLGVLFGSPAPEWLGFTECH
                     EAVSSPYDRDHLEAAVAGNLLFNDFEVGYPVEKAALPPFLDSPSTPGLPGTMLIATTLV
                     LKRAAAVQLGMDAALTLLDRRMLGPRALGEALGVLGPELIPTRLAPRLSTIANEHPIAI
                     LSTLDTLLPRLEPSHRGVFALLELAADLMERGAGTISAETKTWLAGFKGSSKAAKAASR
                     LSR"
     misc_feature    14832..14834
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14985..16118)
                     /locus_tag="AMYAL_RS0133480"
     CDS             complement(14985..16118)
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164753.1"
                     /locus_tag="AMYAL_RS0133480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SWIM zinc finger family protein"
                     /protein_id="WP_020635661.1"
                     /transl_table=11
                     /translation="MITEIQLEPVEEHTATPVLFKGFVEPGAQAAQALLVLGKVARTRF
                     WMPPSMVNRLIAESDPVFTASRTTLRAEAFSPCCGVYARLDLQEVGSLGEGCTNVDLSD
                     ATRTVLAGVVAQDPLHLTVRGEGIHLRTLDGQNDESLVPLPDRWVAGFAEVAAVTAGAV
                     KMAELDKVETQAFLRRLPTAGGRSWAVPSGRGLRLTSRAGRDSIPASGLHRLRVVEPLV
                     RFARGLTVYTRPDSEVASWVLQLERARLVVTLSPEPSRGFSGEGGWLNALAAGLDAPEL
                     VAGRAGHDVVDGTWFPRELPSGNAPVNGRLAKARELVAAGAVRSLPGGGYEITRAGSVQ
                     RVRLSPAGCTCAWWAKHQETRGPCSHVLAARMSAAEA"
     misc_feature    complement(15141..15143)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(16212..16225)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.38"
                     /tool="antismash"
     misc_feature    16213..16226
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.76"
                     /tool="antismash"
     gene            complement(16288..16488)
                     /locus_tag="AMYAL_RS0133485"
     CDS             complement(16288..16488)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMYAL_RS0133485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020635662.1"
                     /transl_table=11
                     /translation="MFANWIQIAELALLPVGLAIGYAAGRICRHDERASFGGGVAITHP
                     GLVSEYQDPTWDAGATWESAR"
     gene            complement(16569..17447)
                     /locus_tag="AMYAL_RS0133490"
     CDS             complement(16569..17447)
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164762.1"
                     /locus_tag="AMYAL_RS0133490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_026467656.1"
                     /transl_table=11
                     /translation="MTEDDAQPDPERAIELLWGAPEPDRPGLSLGRIIAAAIEVADAEG
                     LAALSMRKVAERFGTTTMSLYRYVPGKAELVELMRDAVHGEFPMKPSAGLGWRAGLEHW
                     ARRVWEMHRCHPWLVHSAGTRRLPGPNIMAGYDHALDVASRSGLAPAQVIAVVNLVGGF
                     VESVARQAGETAELQRRTGVSHERWWSERESLFERLDGYPALTRLWKGGGMDAPLDPFE
                     FGLQRTLDGVQALIEGGGSEVMRDETERGECAICGKPLEGVGRGRPRDYCSRACQQRAY
                     RRRQAEASASE"
     misc_feature    complement(17480..17493)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.54"
                     /tool="antismash"
     gene            17534..19333
                     /locus_tag="AMYAL_RS0133495"
     CDS             17534..19333
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164763.1"
                     /locus_tag="AMYAL_RS0133495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_020635664.1"
                     /transl_table=11
                     /translation="MPEIRFFVSPDGRDDWPGTADQPFATAKAAQAAVRAVTAGMTGDI
                     VVTFTAGVHRLEQPLIFDGALGDSGANGFRVVYQAHGYGTPEQVKVELSGGREIGDWQA
                     GDDDVWTAPIGDLAPRRLTVDDHPSTRAARTSGLPGNVTKTATGYVTDSIEPQSWPDPS
                     GLEFVYPGVYPWSEARIAVASISGDASSTTVTMAQPAFDNAKSLYDSKWYGAGGDGTWD
                     GLAAPTVLENNVAFLSEPGTFAVSRTGPGDHVLHYRPRPGEEIGKTIVVAPVLETLISG
                     QGVHDLVLRGFTFADATWNGPTRTGGYLHYHGNTRYEQGEFQKIDLGADVGYVHVPAQP
                     VQLPANVSLTSVSRVTVEDSHFTRLGAGGLLIEDSADVRIRGCVFDDISGSGLAVHTST
                     RVSLEDNLVHHIGTEYRGSSAVLVVESEETTVAHNEIRDVPHNGVVITGGERAKGTQVI
                     SNLVERSMGKLMDGGGIYLSAPQGSSFAGGALVRGNVIRDVLTSYNFGLYTDYGAAWIT
                     VTGNVVHGADTPIVLQVGPPMENVAFVGNFWDVRPDGHDTPPETVTVAANTVLPKETFG
                     EAILADPAGADILARAGRRGLER"
     gene            19404..20033
                     /locus_tag="AMYAL_RS0133500"
     CDS             19404..20033
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334437.1"
                     /locus_tag="AMYAL_RS0133500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020635665.1"
                     /transl_table=11
                     /translation="MPTQPTEAPVTRRRLARIATEVLAPWVWVLGLPLVVAWQVTGHHF
                     GKTLLWGLIVGVTGSLIPMAVIVRGAKKGKWDSHHVTDRAGRLVPFAVCIGSLAAGFVI
                     LIAGGAPHEMIALAAAELVCLVAALAITFGAKFKISMHAMVAAGAAVMLMRVYGPWLAL
                     VFLGVGWVCWSRVELGDHTRAEVTAGTVAGVVLGGGVYLLLDAVLA"
ORIGIN
        1 ctgcggcggc tctacgtcgg cagcgacctc ggccagggct atccgggcga tgaggacaac
       61 ggcgagatgt ccgcctggta cgtcttcggc gcgctcgggt tctacccgct ggcgatgggc
      121 agccccgagt acgcgatcgg ttcgccgctg ttcacgaagg cgaccgtcca cctggagaac
      181 gggaaggacc tggtcgtcaa ggcgcccggc aacaccgagg acaccgtgta cgtccacggc
      241 ctgacgatcg acggacgtcc gcacgagagc agcacgctcg cgcattccgc gctggccgac
      301 ggggcggtgc tggagttcac gatgggcgcg cagccgtcgg actggggccg gacccccgcc
      361 gaaccggcca ccccgtgccc gctcacggac atcaccgcgg gcgccggtgc cctgttcgac
      421 gacaccacca agaccgaggt caccttctcc gaacgggaac cggtcatcga tttccccgtc
      481 gaagacaccg cccgcgacgt cgtgatgtac accctgacct cgggaagccg ccgcggcgat
      541 ccgcgttcgt gggtgctgga gggatccgac gacggcgagc gctggacgct gctggaccag
      601 cgtgagggcg agacgttccg gtggcgcctt cagacccgtc cgttcgccct cgccgagccg
      661 gcgcggcacg cccgataccg tcttcgcatc acctcgtcca ccgccaggcg ggtcaccctc
      721 gcccaaggag agctgctcgc ccgatgatct cccgcatcac ccaggccacg accgaccgtc
      781 tggtcgcctc cgaccccggc ctggtccggc tccggctcgc cttctccgcc gtgctcagca
      841 tcgtcgtcgc ggtgctggcg atcctgccgt tccaccagcc gctcacggtc accctcgtcg
      901 ccgcgatcgc cgcgatgacc tccgccttca ccgtcaacga cacgaccacg gggcagcagg
      961 cggtgacgct gttgctcggg ctggtgctcg gcgcggcgtc gctcaccgcg gccagtgtgg
     1021 gttcggcggt gccgccgctg gacagcgtcg tgttcgtact gttgatcttc gtcgcggtct
     1081 acgcccagcg gttcggttca cgcgggatcg cgctggggtc gctgtcgttc ttcctgttct
     1141 tcttcgcgat gttcctgcag acgcatctga agcaggtccc ggtgctgctg ctggcgctga
     1201 ccatcggcat cgcggccaac gcggtcgtcc ggttcgtcct ggtgcgcaag cgcaccgacg
     1261 cggagttcct ccggatccgg cgggcgttcc gggcgaggct cgccgcggtg gtgcgggcgg
     1321 ccgaggacca tctcgcggtg ggcggcagcg agcgcacccg caagcggctc cgcacgacga
     1381 actcccgcat gcacgagtcg gtgctgctca tcgaggacac cgcgcccgag gtggcgggcg
     1441 cggagtcggc gaaccggctc cgccgtcgcg cgatcgaggt cgagctggcg gtgcagtggc
     1501 tgacgatcac cgtgcagcgc acctgcgccg aggatctcga cgaggacgtc cgtgacgatc
     1561 tgatcgcgcg gatgcggcgg ttccggtcac tgatcgagcg cgatccgcgg gagctgccgc
     1621 tgatcagcga gaccgaagag ttcagcaaga tgctggtgga aggcagccgg atcgacgagc
     1681 acgccgcgcc cggtgacgga gtccgccgcg ccctcgccga actcgcgctg gccgacgtgc
     1741 gggcgcagcg ggtcgccgag cacgacgtct ccgataccgc cgacgatccc gaagatcccg
     1801 acgaggagaa gtctgcggcg ttcgcgtacg acaaccagac ccgcagcgcc attcaggccg
     1861 tcgtgggcgg cgggctcgcc gttctcggcg gcgagctggt gtcgagccag cggtggtact
     1921 gggcggtgct gacggtgttc gtggtgttca tcggctcgtc gaccgcgggg gcgacgttcg
     1981 tcaagggtgt ccggcggctc ggcgggaccc tgatcgggat cgtgggcggg ctggtgctga
     2041 cgctggtggt gtcgggcagt gtgcccgcga cgctggcgct gatcctggtg tgcgtgttcg
     2101 gcatggtcta catggcgcgg gtgtcgcagg tgatcatggc gttcttcatc accagcatgc
     2161 tcggcctgct ctacagcctg ctggggacgt tcagcctcga agtgctctgg atccgggtcg
     2221 cggagaccgc ggtgggtgcg gcggccgggg tgctggcggc ggtggtgatc gtgccggtgc
     2281 gcacgcgcgc ggtgatgctg gacgacgtct cggcgttgct tgacgagctg gacgagttcg
     2341 tcgagaaggc cgcgggcctg ctgtccggtg cggagaacgt gagtgtcatc gagaagtcgc
     2401 gtgatctgga ccgggcggtg gacaaggtcc gcacgacgat cgagccgctc acccatccgg
     2461 tgaatctcag cagccgccgt gactacggct ggcatgtgct cacgacggtg gagacgatcg
     2521 ccttccgcgc ccggcatgtc gccgcgcggt cgcaggccgg gctgctggtc aacgaggcgg
     2581 atcggctgct gctgtacacc gggcggatcc gggagaacat cgtggtgctg gggaaggcga
     2641 tcggcgatcc cggcggttcg gggcacggga cgctggtccg ggacgacggt acgccggtgg
     2701 cggaccggat cgacgatccg cgggcgcgtt cggtgctcac cagtctcggg catctcgacg
     2761 agacggtgat cgcgctgggc cgcgcgttcg gggtggaggc cacggatccg gcgccgtccg
     2821 ggaaagggtg acggccccct tcggttcgaa ggaggccgcc gcctctgggg atcagttctt
     2881 cggtttgggg caggtcttcc acgagaagtg gtaggtggtc ttgatggagc cgtcggtcga
     2941 gtccatggtg acgaagctgg tggtcttctt cggatcggaa gtgccgaccg cggcccgcaa
     3001 ttccgtgttg atgttgaagt tgcggtcctc gccgcagggt ttgtagacga tggccccgac
     3061 ttcgatgttg tcggtgaact gccagttgtc ctccaacggg cccttgaggg tgtggttcac
     3121 gttggctgtc ggggaattgc cctggaagta gtagttcgct cgttccaggc cggtggcccc
     3181 cgcggccagg gaagcgaatc cacggtaatc ggtgcccgcg ataccgtagg tgaatccctg
     3241 cggtacgtgg acatagaggt tgagctggca gttcttgcgc agatcggtcg gcttggcacc
     3301 gagtccgacc tgggcggtgt attcgctgta ggtgaccgtg aacgcggtgt tgtccggtga
     3361 tacggaaata gccgcggtac ccggtctgca tccggttccg atgatcgtga cgacgtcgat
     3421 gacgatcttg tcggacggca ggggcggcgg cacccagccg ctcggcgtga cgaccgagga
     3481 gagcagcgtc acggcggcaa ccagcacgtt gagcatgaga tccttcccaa agcttccacg
     3541 cggcgggaac tgggcggatg cgatgtcagc gagacgatct cgtcccggcc gcccgccgat
     3601 cggacgaaac ggattcggtc accggactca ggggcgaccg cggaaacagg gtcgtcgaga
     3661 agactcgccg ccgccgggca gggcgacgac gagccgcgat ttcctcggtt caggcggcca
     3721 gcgccctgac cggggtatgg gtgggagacg gccttcttcc ggaccgggaa gcaggccgtc
     3781 accctgggga cgatgtcagg agcccggaca gaccttccac gagaagtgat aggtggtgtg
     3841 gaacgcaccg tcggtggaat ccatcgtgat gaaactggtg gtcttcctcg gatccgacga
     3901 acccgccgcg accctcagtt ccgtgttcac gttgagattc cggtcctcgc cgcagggctt
     3961 gtagatgatg actccgccct cggcctcgtc gcggaattgc cagttgtccg acaacggccc
     4021 gttgatgggg tggctcacct gcgcggtcgg cgaattgccc tggaaatagt aattcgcccg
     4081 ctgcaaaccc tttgcgcccg gctcgagcgc cgcgaaaccg cggtaatccg cgctggcgat
     4141 accgtaggtg aatccctgcg gcacgtggat gttgagattc agctggcagt tcttccggaa
     4201 gtcggtgggc ttcgcgccga ccccgacctg cgcggtgtat tcgctgtagg tcacggtgaa
     4261 ggcactgttg tccctggcga cggcgaccgc ggacgaaccc ggcgggcaac cggagccgtt
     4321 gaccgtgacc acgtcgatga caacccggtc gggcggcggt cccggcggcg cccagctatt
     4381 cggtgttaat atcgtcgaga aaagtgatac ggcggcaacc actgcattga gcatggggtc
     4441 cttcccaaaa cttccacacg gggggcgggg aactgggcgg actcatgtta gcgaaacgat
     4501 ctcggcgatg ccgcccgccg atcggacgaa accatcccgg caatcggttc atgaaattat
     4561 attatggtct gtaaccgttt tccgggggcg gcgaaaaagc cactttaccc ggaaaacacc
     4621 actcggttcg cacgatatgg aaattgcgtt cgcggactgc tgttgacggt tccggaaaga
     4681 cagccccgct caggcggcga tcagccccac ggcctcgccg agcaccgcca ccgcctccgg
     4741 ccgccatggc ccggcggtga tcaccaccac gtggtcgagc ccccacgacg cgaactcggc
     4801 gcaccggccc gctaagtcct ttgaggactc ccctggcgcc agccgggtcg cgatggtctt
     4861 ctcgatctcc tcgaccggcc gtccgacgtc ggcgcagtgc cgggcgagga cgtccagatg
     4921 cccgcggacg gtcttgccgc cgtcgggaac gtcgaagagg ttgcacgcgt cggcgtactc
     4981 ggcgaccagc cgcagcgtcc gcttcggccc ggtgccgccg atgagcaccc gtggccgccg
     5041 gaccggcagc gggttgttga ccggccgttc cagccggtaa tgccgaccgg tgaacgcgga
     5101 gctgttgccg tcccacatcc ggcgcgcgat ccgcagggtc tcctccagcc gctcgaaccg
     5161 ttcggcgacc ggcgggagcg acagtcccat cgcgcgtgcc tcgtcctcct gatatcccgc
     5221 gccgatcccc agccaggccc ggccccgcga aaggacgtcc agcgtggtga cggccttcac
     5281 cagcagggcg ggcgcccgga aggtggcggc gctgaccatc gtgccgagtt tgatccggga
     5341 cgtctccgag gcgaggaagc ccagggtggt gtacgcctcc agcatttccg agtccggatc
     5401 gctgcccggc gcggtctgca ggagatggtc ggccacccac agggtgtcga ggccggtcgt
     5461 gtcggccacg cgggcgacct cggcgaggtt gtcgaccagc gcggcctgcc cgccgggcca
     5521 ggagaagtcg gtgacactga cactgattcg catgattcac gtccttgggt gagaggtatg
     5581 acagtgggag cacgttgcga aagccacttt ctttcgcaac gctgaaggtt gcgaaagtgg
     5641 ctttcgcaac gccgccgccc ggaggccgag ggcactcagg gggcttcagg gcgcgcgaag
     5701 ggcggcggtc cggcgatcgg gctcaggtgg atgccggcga tgagccaccg ttcgccatcg
     5761 cgcacgaaca cgtgggtgac gcggaatcgg ccgtcgaccc ggttcccctg gtgcgttccc
     5821 tcctgtgcgt gcacgccgac ggacacggcg gccgcgcggt agtcgcggat ttcgacctcg
     5881 gcccagtcga gcttctcggt gatcaggtcc ccgccccggt agcgctgcag ccattgcggc
     5941 ttgccgagga cgaaacccag cggcccgacc agggtgaagt cggccgccgt catcctgtcg
     6001 agtgcttccg tgtcgccgcg gacctcggcg tcggcccagc gggctccgag ctcgcggatc
     6061 tcgttctccg tgctgcgcat ggcgttccct ccatctcgtt cgatgtccac aacgttagat
     6121 atcgaacgtt tcgatgtcaa acgcttagat tgatgcgcta tactgggtgg cgtgcagaaa
     6181 ccgaccacgg cacccatcgg cgtcgtcctc gccaagaccg cgaagaccgt cgggcgcgcc
     6241 ttcgaccagg cgctggccac cgacggcggc tcgcagccgg tctggcagat cctgatcacg
     6301 ctgaagaccc ggcgcgtggc caaccagcgg gaactcgcgg ccgcggtcgg catccagggc
     6361 gccacgctga cccatcacct caacgcgatg gagagcgcgg gcctgatcac ccggcggcgc
     6421 gacccggaca accggcgcgt gcacgtggtc gaactcaccg acgagggtga aacggtcttc
     6481 caccggctgg cgaaagcggc gatcgcacac gacaaacgga tccgcgccgg attcagcgac
     6541 gaagagatca ccacactggc cgggctgctg tcccggctcg ccgcgaacgt ggccggtggt
     6601 ggcatcgatc aagaaaacag tgactggacg cacccgaacg gcgactcggg acaggactag
     6661 catcgcggta caaagtcgat gtcgcctcaa gctggagaac cgcaatgacc caagcccctg
     6721 tcaacgtcac cgtcaccggt gcggccggcc agatcggcta cgcgctgctc ttccgcatcg
     6781 cgtccggtca gctgctcggc ccggacaccc cggtgaagct gcggctcctg gagatcccgc
     6841 aggcggtcaa ggcggctgag ggcaccgcga tggaactcga agacggcgcg ttcccgctgc
     6901 tgtcgggcat cgacatcttc gacgacccga agcaggcctt cgagggcgcg aacgtcgccc
     6961 tgctggtcgg cgcccgtccc cgtgccaagg gcatggagcg cggcgacctg ctcgaggcca
     7021 acggtggcat cttcaaaccg cagggcgagg ccatcaacgc cggcgcggcg agcgacatca
     7081 aggtcctcgt ggtcggcaac ccggccaaca ccaacgccct catcgcgcag gcgcacgcgc
     7141 cggacgtccc ggccgaccgc ttcaccgcga tgacccgcct cgaccacaac cgcgcgctcg
     7201 cgcagctgtc gaagaagctg ggtgtaccgg tgacggagct gaagaaggtc gcgatctggg
     7261 gcaaccactc cgcgacccag tacccgtcga tcgcgcacgc cgaggtgtcc ggcaagccgg
     7321 cgaccgaggt catcaccgac cagcagtggc tggccgagga cttcatcccg accgtcgcca
     7381 agcgcggcgc ggcgatcatc gaggcccgcg gcctgtcctc cgccgcttcg gccgcctccg
     7441 cggcgatcga ccacgtccac acctgggtca acggcacccc cgagggcgac tggacctcgg
     7501 cggcggtcgt gtccgacggc tcctacggtg tcccggaggg cctgatctcc tcgttcccgg
     7561 tcaccgccgc gaacggcgag tacaagatcg tccagggcct ggagatcgac gacttctcgc
     7621 gcgcccgtat cgacgcttcg gtcaacgagc tggccgaaga gcgcgacgcg gtgaagaagc
     7681 tcggcctcat ctgagcctga tccacccgtg caaggcggcc gtgtcccgag gggcacggcc
     7741 gcctttccgg ttcagctcgc ccgccggtcc gcaccgatga tcgtgtcgag gttggcccga
     7801 gtgctttcca gctccccgat cgcctcgtcg atccggttcc gctgctgccg cagggcgtcg
     7861 acgagttccg ggcagtcggg tgtcagccag ccgtcctcgt cgatgatgca gggcaggatc
     7921 tccaggatct gcgcggtgtt cagcccggcc ccgagcagga tccggatccg ccgcaccgcc
     7981 gccacgtcgg cgtcgccgta cacgcggtag ccgctcggcc gccgctgcgg ggtcagcagc
     8041 ccctgctcct cgtaataccg gagcgcgcgc tcgctgacac ccgtccgccg cgcgagttcc
     8101 ccgatcctca tccgcgctcc agccttgact ctcacgtcga tgtcaaggtt tagcttagcc
     8161 gccatgacca ccgtgaccgt cctcggactc ggccccatgg ggcacgccct cgccgccgcg
     8221 ctcaccgccg cccgccaccc caccaccgtc tggaatcgca ctcctggcaa ggaaaacggc
     8281 ctcgacgcca ccgtcgccgg gacggccgcc gaagcgatcg cggccagccc gctcgtgatc
     8341 gtctgcgtcc gggactacgc cgtggcacag tcgatcctcg acgccgaagc gctcaagggc
     8401 cgcaccctgg tgaacctcag cggcggatca ccacgacagg cccgcgcgat ggcggactgg
     8461 gccgccggga acggcatcga ctacctcgac ggcgtcatca tggcgacgac cgacgcgatc
     8521 ggcggccccg acgccgcatt gttcttcagc gggcccgccg acgtctacga aacgcatcgc
     8581 tccaccttgg ccgcgctcgg cgagaacgcg cgcttcgtcg gcgattccgc cggccgggcc
     8641 gccgcgttcg acgcgtccct gcaggacatg ctctggacct cgatgagcgg cgtggtgcac
     8701 atgttcgcgc tcgccaaggc ggaaggcatc gccgccgccg acatcgcagg ggaagcgaaa
     8761 gcgttgctcg gtttcttccc ggacatgatc gacgtgctcg ccgaacaggt cggctcggac
     8821 cgttaccccg gcgagtacgg caccatcggc tccgccgcgg cgaccatgga ccacgtcctc
     8881 gacgcgatcc gcgcgcgaga cctcgacaac ggcgtgctgt ccgccgcccg cgccgaggcg
     8941 cagcgagcca tcgacgccgg gcacggggag gacggcttcg gcaggctcgc cgcaccctag
     9001 gcctattctt gttttatgcc aaccccacag ggctattcgg gtactattcg acccatggac
     9061 ccgagagggc ggtaacatga tcacgatctg acccggcagt cccaccctgc gaaaggggat
     9121 catgccttcc tcacccgccc ctggctccga ccgcgcccgg ctcgcgatga agcttcgcga
     9181 actccgcgcg gccaccggga tgtcgggtaa ccagttcgcc aaggaactgg gctggccgca
     9241 atcacgggtg tccaagatcg aaacagccgc gcagttcccg accggcgacg acatcgtcgc
     9301 ctggctcggg acggccggcg cccgcggcga agagaacgtg gtcaccgaac tgctcaggcg
     9361 cgcgcgggtc gaatcggtgt cggtccgcca ggagttcggc aaggcaggcg gggccggggc
     9421 aacccagcga tcggtccacg agcaggaacg ccaggcggcc agggtcgcca ccttccaacc
     9481 ggcgatgctc cccggtttgc tgcagacacc cgctttcatg cgcagcctgc tgtccctgcc
     9541 gtccgggccc gcacagatgg gcaacgcctc cagcgccgac atcgaacagc tggttgccgc
     9601 tcgcatcgaa cggcaatcgc tgctgtacca aggcgacaag gacctgccgt tcgtgatcgg
     9661 cgaggctgcc ctgtggatcc gcgtcgggga cctggagacc cagctcggcc agctggaccg
     9721 gcttcagtcc ctggccggcc tgcacacggt cgacctccgg atcctgccct tcgggaaagc
     9781 caccccgatc gccccgctgc acggattcag gatcatcgac gccgagttcg tcgcggtgga
     9841 gaccttcacc ggcgagcatc agctcaggga cccggacgaa atcgccctgt accggcaact
     9901 gttccgcctg ctgcacgaag aagcggtcgg cgaggaggaa gcggccgggc tgatccggcg
     9961 tgtgtcgcgc cgtctggtca ccgaagaccc ggatgggtga tcaccccgcc atccggcaag
    10021 cccggcattc cgcatgcgac tcgtcgagac cggtgatgaa actgtggtcc atggtggcga
    10081 gactgaaccc gtactggcaa ttcagccgga gcatcggcgc gtccgtgatc aggcgcatcg
    10141 ccgcgtgcgc gaccaggttg ccgaccacac cggcagtcac cgcgttcgcc gcgttcaccg
    10201 ggacctccgt cggagtcctc caggtctcca gcggtggccg caacgcctca cggtcctgtt
    10261 cggcgaggcg ggcgcattcg taacacggcc ctgcacccgg acggtagatg ccgacgttga
    10321 cctgcgggcc gtgatagccc ccgtgcaccc aaggggtgcc ggtggacacg cacgcctcat
    10381 tcgtccaggc ccggagctcc gaaggctggt cggcgaccat caccagcacg tcgcaatcgg
    10441 cggccagcct tcgcagggag gccacgtcct tgatcctcgt cgcctctccg gtgacctcga
    10501 tgtcggagtt gaccgcccgc agccggtcca ccgccacctc caccttcaag cggcccagat
    10561 cccgctcggt gtagaggatc tggcggctga ggttggacag ttcgaccaca tccggatcga
    10621 cacagtgcag ccgtcccacc ccggacatgc acagtcccag agccgccgtg cagccgacgc
    10681 cgccaacgcc gaccaccacc acccgcgcct cggcaaggcg gacctggaaa tcccagctcg
    10741 agatcctgcg cttcaggtcg atccagcggt acagcgaccg gcctctcgaa tgccgttcac
    10801 gctgccgcgc gctcaacgcg gtgcactccg gctcgtcggc gtcctcgaca tatccgagtt
    10861 cgaccagtct ttcgatggcg tccgcggctt cctcggcgga gcacgacggg aagcgccgcg
    10921 tcaggtcggc gaccacctga ccgaccgttc gcgtcccgtc cagacaggcc agcagcgccc
    10981 acaccgcgcc atccggatcc ttcagctcgg cggcgatgcc gaacaccttc ccgccgatcc
    11041 gaatcccgtc cccgaaacgg accggtcgat gctcgccttt cacgcgtgga cgcatcagaa
    11101 cctcccctcg gtcagttgtt gtcggcgcag tagacgtggt gtaccgcgtc ggcgcgctcc
    11161 accatcacga tctcgatcat tgccatccac ctcccccgct caggccccgc cggtgacccc
    11221 atcgcctcca caatgtagaa tcgcgagttg tagacgttct caaatgtaga gcttcacatt
    11281 gtgggagtcc atggcagcac cgtgggccat gcgggtgatg tcgtggtcgc actacgtgac
    11341 caccctgaag aggcggtgac ttcatgagca cgctgaaccc cactgccgtc aagcgctgga
    11401 tcgcgctcga gatgaagcgc ctccgggaag ccgccggcta cgacagagcg accgcggcgg
    11461 aacgtatcgg caaggcaacc acggtcatcg cgcacatcga gaccgcacga aacctgccgg
    11521 cgcccgccga cctggaaatc ctgctcgcct tctacggcgc accggagaag gtcgaattct
    11581 tccgcgacat gaccaggcga gcgaaacgcg gccgcgactg gtggatcaaa ttcaaccgag
    11641 cggtgcccga atggttgaat ctgtatctgg ggctggaaac cggcgccgcg cgcatcaaca
    11701 ccgtcgatct gatcgcactt cccggactgt tccagacccg tgcctacgca cgcgcgatca
    11761 tgctggaagg ccggaaatgg tcctccgaag ccgaactcga cgccatggtc gacctgcgga
    11821 tggcgcgaca ggagatactc gagcgcaccg aagacgctcc gcagatctgg tcgatccttg
    11881 acgagagcgt cctgcggcgg cagatcggcg gacctgcggt gatgcgtgag caactgcagc
    11941 acttgatcga cctgtccgaa cgaccgaaga tcgacatcca ggtcctcccc ttcagcgcgg
    12001 gcgcccacgg cgcgtcggac ggcatgttca tcatcttgac ctatccaccc gagttccggg
    12061 gcgaccctgg aaccgtttat gtcgaaaatc gacgcgaagg cctctactac gagagcgccg
    12121 cagctctcct cgattttcgc aacacattcg aacgacttca ggttcaagcg gagaaccctg
    12181 aacgttcacg tgctctgatc cgcgattgtg caagggaaat tgatgtccac tgattcaccc
    12241 cgccccaccc tcaccactgt ttcgggctgg tggaagtcca gctacagcaa tggggcgagc
    12301 ggttgcgtcg agttcaacgc ctccatgccc ggctacgtcg gcgtgcggga ttcgaagctc
    12361 ggcgagaaaa gcccggtcct cgtgttcaca ccgcacgaga tccaagcgtt cctgacgacg
    12421 ctcacgaacg gaactgggcc gagatgtccg tgaaggactc cttgagggag tcagaggccg
    12481 ggtctcgtga cgctcaacgt ctcgagcgtg gcgctcgtga cctcggccgt agcccctcac
    12541 gacacaatgg ccccgtgcac ctggacgcga tcctcaccgg tcaaccctcg gaagtcctct
    12601 cccggatctt cgggctctcc cccgccgagc ggaaagccct catccccgac ctcatggccg
    12661 cgttcaagga cagccgagaa ttcatcgaga tcgaacccga cacctacggc gtccgaaacc
    12721 cgctcaaagg ccagcaagcc gccacggccc tcttggccat ccttcccaca agcgaccccc
    12781 tgctccggaa actctggatc gccacaccca cgatcctcga acgcgtgctg caggaccggc
    12841 ccctcgccga acgcaaggcg atggctctcc gcctgatcgg ccaccagacc gcgtgggaag
    12901 cgatccgccg catgaccctc gacggcgacc tcgaacccat ccggacaccc gagtaccacg
    12961 cgggctggtt ccgctgggcc ggacgcttcg gcggaaaacc cctcgccgaa cggctccgaa
    13021 ccgaacccga agcgctcacc gaactctggg aactcctcac gctcgaaggc aacggggatg
    13081 ccagcttcgc cgccttcgac aagtacgtcc gcgacgaaga caaatggtcg accgcgctcc
    13141 tcgaactcac cgccaccggc gaactcgacc gcaccagact gctcgacctc accctcgacg
    13201 tcctcgcccg cgacttcgcc gcctttcgcg cccagtggta cgccgccctc cacgaagcgc
    13261 tcgcacccac accggacgaa cgcacaacgg cacaaatccg ctacgcccgg ctatgcggaa
    13321 gcagcctccc ccgcactgtc tccttcgccg tcaaagcact gtctctcgtg gacaaacaag
    13381 gcaccctcga cgacgaaatc gccctccagc acctccccgc cgccgcggcg ggacgaggcg
    13441 ccaccaccgc caaactcgcg ctcaaactcg ccggccgcat cgcagaccgg cgacccgaac
    13501 tcaccgacat cgccaacgaa gtcttcgaag cggcactcac ccacgaagcc tccgacgtcc
    13561 gcgccctcgc caccgcccgg ctcggcgtca cccccgagac accggacgtc atcgacaccg
    13621 ccgaataccc cgaacccaca cgaccaccct gggaccagcg caaaacactg accatcccgc
    13681 tcgacgtccc cgacaccccg gccgcgatcg cggaagccct ctcctccctc ctcgccgatc
    13741 ccgaccaggc cgacctcctc ctggccgtcc tcgacggcgc acaccgcgtc accggcgaac
    13801 tccaggacgc cctcaaacca ctggtgaaac gcgccaccaa gatcgcaggc gagaagcacg
    13861 ccgcggccgt ccccaaactg gtcgccaccc tcgtcctcgg cctcagcggc cgcgacgtcg
    13921 cctgcccacc acaggtcgag ggctggcgtc gtccgctcca ccaccgggtc aacgccctgc
    13981 tggacggcac cgcccgccct gtctccgccg ccacccacca gggcggctgg ctcgacccgg
    14041 tcgtcttcgt ctcccgcatg ctcgaacacc cggaagcacc cgaagacgac gtcgccgacg
    14101 cgctgctgag gcttgccccg gacacccggc ccgaagcccg ctcactcgcc tcggcactca
    14161 ccggcccgca cgccgactgc atccgctacg ccctcggcgg accgcccatc ggcgacaccg
    14221 gctggaccgc cctcgccgcc gcccgtgccc gataccccga atccgccgac cccgccgctg
    14281 cgctgcgcgg tgaccccgga ccgccgttca cctggacggc gaagatcggc ctgaaccagt
    14341 acggcttgac ctcgctggac atcgacgaaa ccccggaagc cgtctcaccg aaagccccct
    14401 ggctgggcgt gcttttcggc agcccggcgc ccgaatggct cggcttcacc gaatgccacg
    14461 aagcggtctc ttcaccctac gaccgcgacc acctggaagc cgccgtcgcc gggaacctgc
    14521 tcttcaacga cttcgaagtc ggctaccccg tggagaaggc cgcgctgccg ccattcctgg
    14581 acagtccttc gacacccggc cttcccggca cgatgctcat cgccaccacg ctcgtgctga
    14641 aacgcgccgc cgccgtccag ctgggcatgg acgccgcact gaccctcttg gaccgacgga
    14701 tgctcggccc tcgcgcgctc ggcgaagcac tgggcgtgct cggccctgag ctcattccga
    14761 cgaggctggc cccccggctt tcgaccatcg cgaacgaaca cccgatcgcc atcctgtcca
    14821 ctttggacac cttactgccg aggctggaac cttctcaccg cggcgtcttc gcgctgttgg
    14881 agctcgccgc ggacctgatg gaacgcggcg cgggcacgat cagcgccgaa acgaagacct
    14941 ggctggcagg tttcaaaggc agttcgaagg cggcgaaggc ggcatcacgc ctcagccgct
    15001 gacatccggg ccgccagtac gtgcgaacac ggcccccgtg tctcctgatg cttggcccac
    15061 caagcacagg tgcaacccgc cggggacaac cgcacccgct gcaccgaccc ggcacgggtg
    15121 atctcgtagc cgccgccggg taacgaccgg accgccccgg cggccacgag ctcacgcgcc
    15181 ttcgccagtc ggccgttcac cggagcgttc ccgctcggca gctcccgcgg gaaccacgtg
    15241 ccgtcgacga cgtcgtgtcc ggcacgcccc gcgacgagtt ccggcgcgtc gagtcccgcc
    15301 gccagcgcgt tcaaccaacc gccttcaccg gagaagccgc gggacggctc cggagacagc
    15361 gtcacgacga gtcgcgcgcg ctccagctga agcacccagc tcgcgacctc actgtccggt
    15421 cgtgtgtaga cggtcagtcc tcgggcgaac cggacgagtg gctcgaccac gcgcagccga
    15481 tgcagtccgg acgccgggat cgagtcacgg cccgcacgcg acgtcagccg gagcccacgc
    15541 ccggacggca cagcccacga cctgccaccg gcggtgggca gccgccgcag gaaggcctgt
    15601 gtttcgacct tgtccagctc cgccatcttg accgcgcccg ccgtgacagc ggcgacctcg
    15661 gcgaagcccg ccacccagcg atcaggcagc ggtaccagcg actcgtcgtt ctgcccgtcg
    15721 agagttcgca agtggattcc ctcaccgcga acggtcaggt gcaacggatc ctgtgccacg
    15781 acgcctgcca gaacggttcg tgtcgcgtcc gacaggtcga cgttcgtgca cccttcaccg
    15841 agacttccga cttcctggag atcaagcctg gcgtagacgc cgcagcacgg cgagaaagcc
    15901 tccgctcgca acgttgtccg gctcgcggtg aacaccggat cggactcggc gatgagccgg
    15961 ttcaccatcg acggcggcat ccagaaccgc gtgcgggcga cctttcccag tacgagcagc
    16021 gcctgagcgg cctgagctcc gggttcgacg aaacccttga agagcaccgg cgtcgcggtg
    16081 tgctcttcga ccggctcgag ctggatctcg gtgatcatcg ggcaacccta gccagtaccc
    16141 ccgacactct tggcggtttt gattgtcaga tcgtgtagtt gatcttgttc gttgccaagg
    16201 tgaataggtc gttatacact ttataaccga cgacaggccc cgagcggatt ctcccgagac
    16261 ctgccgccgc cctcccccgg aatcggccta cctggccgat tcccaagtcg cacccgcgtc
    16321 ccaggtgggg tcctggtatt ccgaaaccaa gccggggtgg gtgatcgcga ctcccccgcc
    16381 gaaggaggcg cgctcgtcgt ggcggcagat tcgtccggcc gcgtagccga tcgcgaggcc
    16441 cactggcagc agtgcgagtt cggcgatttg gatccagttg gcgaacatcg gtctccccgc
    16501 tctccgacct accgtgtcct cccgatgcta ttcgccagct atgcacgtcc gaagcggcta
    16561 ttcgtgtact attcgcttgc ggacgcctca gcctgccgcc ggcgataggc acgctgctga
    16621 catgccctcg agcagtagtc ccgcggcctg ccccgcccga ccccttccag aggcttgccg
    16681 cagatggcac actccccgcg ctcagtttcg tcacgcatta cctcactccc cccgccttca
    16741 atgagcgcct ggaccccgtc gagggtgcgc tgcagcccga attcgaaggg gtcgagtggc
    16801 gcgtccatac cgccgccctt ccacagcctc gtcagggcgg gatagccgtc gaggcgctcg
    16861 aacagggact cgcgttcgct ccaccagcgt tcatgggaca cgcccgtgcg gcgctggagt
    16921 tccgcggtct cccccgcctg ccgcgcgacg gactcgacga atccgccgac caggttcacg
    16981 accgcgatca cctgcgccgg cgccaggccg ctccgcgaag ccacgtccag cgcgtggtcg
    17041 tacccggcca tgatgttcgg ccccggaagg cgacgggttc cggcgctgtg gaccagccac
    17101 gggtgacaac ggtgcatctc ccagacccgt cgcgcccagt gttcgaggcc cgcgcgccag
    17161 ccgagcccgg ccgaaggctt catcgggaac tcgccgtgca cggcgtcgcg catgagttcc
    17221 accagttccg ccttgccggg aacgtaccgg tacagcgaca tggtggtggt gccgaaccgt
    17281 tccgcgacct tgcgcatcga cagcgcggcg agtccctccg cgtccgcgac ttcgatcgcc
    17341 gccgcgatga tccggccgag actcaacccc ggccggtccg gttcgggtgc gccccacagc
    17401 agctcgatcg cccgctcggg atccggctgc gcgtcgtctt ccgtcaccag cactccttga
    17461 cgctcttcgc tcattcgtgt ttaagtaata aaccgcagta tatcccataa acctcccgca
    17521 ggagcacttc agtatgcccg aaatcagatt cttcgtgtcc cccgacggca gggacgactg
    17581 gccagggacc gccgaccagc ccttcgccac cgccaaagct gcgcaagccg ctgtccgcgc
    17641 cgtcacggcc ggaatgaccg gcgacatcgt cgtcaccttc accgcgggcg tccaccgcct
    17701 cgaacaacct ctcattttcg acggtgcact aggcgattcc ggcgcgaacg gcttccgcgt
    17761 cgtctaccaa gcgcacggct acggaacacc ggaacaggtc aaggtcgaac tcagcggcgg
    17821 ccgcgagatc ggcgactggc aagccggtga cgacgacgtc tggacggcac cgatcggcga
    17881 cctggcgccg cgacggctca ctgtcgacga ccatccttcg acccgagcgg cccgcacgtc
    17941 cggcttgcca ggaaacgtga cgaaaacagc gaccggctac gtcacggaca gcatcgagcc
    18001 tcagtcatgg ccggatccgt ccggcctgga gttcgtctac cccggcgtct acccgtggtc
    18061 cgaagcccgg atcgcggtcg cgtcgatctc cggtgacgcc tcctcgacca cggtcacgat
    18121 ggcgcagccc gccttcgaca acgccaaatc cctctacgac tcgaagtggt acggagccgg
    18181 cggcgacggg acctgggacg gcctcgccgc gcccaccgtg ctcgagaaca acgtggcgtt
    18241 cctgtccgag ccgggcacct tcgccgtcag ccggaccggg ccgggcgacc atgtcctgca
    18301 ctaccgcccg cgacccggcg aggagatcgg caagaccatt gtcgtcgccc ctgtgctcga
    18361 gacgctcatc agcgggcagg gcgtgcacga cctcgtgctg cgcggcttca ccttcgccga
    18421 cgcgacctgg aacggcccca cccgcaccgg cggctacctg cactatcacg gcaatactcg
    18481 ctacgagcag ggcgagttcc agaagatcga cctcggcgcg gacgtcggct acgtccacgt
    18541 gcccgcccag ccggttcagc tgcccgccaa cgtcagcctc acgtcggtca gccgggtcac
    18601 ggtggaggac agccacttca cccggctcgg cgcgggaggg ctgctcatcg aggacagcgc
    18661 cgacgtccgg atccggggat gcgtcttcga cgatatctcg ggcagtgggc tcgccgtgca
    18721 cacgagcaca cgggtgtcac tcgaagacaa cctcgtccac cacatcggca ccgagtaccg
    18781 cggttcgtcc gccgtcctcg tggtcgagtc cgaagagacg accgtggccc acaacgagat
    18841 ccgcgacgtc ccgcacaacg gcgtcgtgat caccggtggc gagcgggcca agggcaccca
    18901 ggtgatctcg aacctcgtcg agcgcagcat ggggaaactg atggacggcg gcgggatcta
    18961 cctttcggcg ccgcagggct cgtcgttcgc cggcggggca ctggtccgcg gcaacgtgat
    19021 ccgcgacgtc ctcacctcgt acaacttcgg tctctacacc gactacggcg ccgcgtggat
    19081 caccgtcacc ggcaacgtcg tccacggggc cgacaccccg atcgtgctcc aggtggggcc
    19141 gccgatggag aacgtcgcct tcgtggggaa cttctgggac gtccggcccg atggccacga
    19201 caccccgccc gagacggtga ccgtggccgc gaacaccgtg ctgcccaagg agaccttcgg
    19261 ggaagcgatc ctggccgacc cggcgggcgc cgacatcctc gcgcgggcgg gacgtcgcgg
    19321 tctggaacga tgatcaccgc tcctgccggg cccacgtccg gcaggagccg ctccggccac
    19381 gatccccgag gagaccacgc accatgccga cccagcccac ggaagcgccc gtgacccgcc
    19441 gccgtctcgc gcggatcgcg accgaggtgc tcgcgccgtg ggtctgggta ttgggcctgc
    19501 cactggtcgt cgcgtggcag gtcaccggcc accacttcgg caagaccctg ctgtgggggc
    19561 tcatcgtcgg cgtcaccggc tcgctgatcc cgatggccgt gatcgtgcgg ggcgccaaga
    19621 agggcaagtg ggacagccac catgtcaccg atcgcgcggg acgactcgtc ccgttcgcgg
    19681 tctgcatcgg ctcactggcc gccggattcg tcatcctgat cgcgggaggc gccccgcacg
    19741 agatgatcgc gctcgcggcc gccgagctcg tctgcctggt cgccgcgctc gcgatcacct
    19801 tcggagcgaa gttcaagatc tcgatgcacg cgatggtggc ggcgggcgcg gccgtgatgc
    19861 tcatgcgcgt ctacggcccc tggctcgcgc tggtgttcct cggcgtcggc tgggtctgct
    19921 ggtcccgcgt cgaactcggc gaccacacca gggccgaggt cacggcggga acggtggccg
    19981 gtgtcgttct cggcggtggt gtttacctgc ttctggacgc cgtactggcc tgagccacgc
    20041 cgtataggtc gttatacatc tgtcttcatg gacaactgcc cgagccgtcg gatgccttcg
    20101 gtgagttcgg cgatgtcggc cgtggcggcg aagcccagtc gcaagaacgg cccggcaggc
    20161 tcggtggcga agaaccgctc ccccgccccg accacgactc ctcgctctct cgcggcgcgg
    20221 gcgatcgcgt tcgcgtcact ccccgccggt agccgcaccc acaggtgcag tcctcccgag
    20281 ggcaggcggg cgactgtcca ttcaggacat tcactggcca gtgccgcggc cgcttttccg
    20341 caccgttccc gcagttccgc acccagtttc cgcacgtgac gttcccagga cggcgcgctg
    20401 agcagttcga gagccgcctc ctgcagcggc cgggagacga agaagtcgtc gacccgccgg
    20461 atcgccttca tccggtcgag gaccggtcct cgcgcgatca acgcgccgat ccggaggctc
    20521 ggcgcggcgg ccttggtcac cgacgtcaga tggacgaccg tgccgtcgcg gtcttcggtg
    20581 atcagcgggc gcggtgccgc ggccccgtgt gacagatggc gggcgaaatc gtcctccagg
    20641 acgaacgctc cggccgcccg cgccacctcg agcaccggac ggcggcgatc ggccgtgagc
    20701 acggtcccgg tcgggttgtg gaacgcgggc tgacagtaga aaagccgggc tccggtcatc
    20761 gcgaacgcct cggccagcag gtccgggcgg accccgtcgt cgtcgatcgg gaccggcacc
    20821 ggacggagcc ccgccgcccg tgccgcggcg agcgctcccg gataggtcgg cgattcgacg
    20881 aggaccgggc ttccgggcgc cgcgatggcc cggaacgcca tggacagccc gctttgcccg
    20941 cccgcggtga tcaggacgtc atccggtgac gcacccgccg gtcccgcgaa gaccgacctc
    21001 agtgcggcca gaccggcagc gggtgcgcgg tcccaggcgt ccggacggcg gcctgcccgc
    21061 gcgagtgccg cgctcaggaa ccgggccgcc tgcag
//
