LOCUS       NZ_KB913032            21146 bp    DNA     linear   CON 28-APR-2024
DEFINITION  Amycolatopsis alba DSM 44262 scaffold1, whole genome shotgun
            sequence.
ACCESSION   NZ_KB913032
VERSION     NZ_KB913032.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Amycolatopsis alba DSM 44262
  ORGANISM  Amycolatopsis alba DSM 44262
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9811274)
  AUTHORS   Klenk,H.-P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Amycolatopsis alba DSM 44262
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: India
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 44262
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v. 4.24
            finishing_strategy                :: Missing
            environment                       :: Soil
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi10729
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2011
            Isolation Site                    :: Soil
            Cell Shape                        :: Filament-shaped
            Motility                          :: Nonmotile
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram+
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v.
            4.24
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina GAii
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000384215.1-RS_2024_04_28
            Annotation Date                   :: 04/28/2024 01:36:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,988
            CDSs (total)                      :: 8,922
            Genes (coding)                    :: 8,855
            CDSs (with protein)               :: 8,855
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 24 of 67
            Pseudo Genes (incomplete)         :: 49 of 67
            Pseudo Genes (internal stop)      :: 4 of 67
            Pseudo Genes (multiple problems)  :: 10 of 67
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7047308
            Orig. end                         :: 7068454
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB913032.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 404842
            Source DNA and Organism available from Hans-Peter  Klenk
            (hpk@dsmz.de)
            Source DNA available from Hans-Peter  Klenk (hpk@dsmz.de)
            Organism available from Hans-Peter  Klenk (hpk@dsmz.de)
            Contacts: Hans-Peter  Klenk (hpk@dsmz.de)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21146
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="29"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21146
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21146
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11146](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11146)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(420..435)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     gene            1030..1266
                     /locus_tag="AMYAL_RS0133215"
     CDS             1030..1266
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032714.1"
                     /locus_tag="AMYAL_RS0133215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_245193210.1"
                     /transl_table=11
                     /translation="MQTRDSWLCLAMAVLAGWAPTLRMCLLLTIGGGIVVGVVRISTPQ
                     VGASAGTCVGLLTLFGAWIVKARQGKQRREPSL"
     gene            1396..2871
                     /locus_tag="AMYAL_RS0133220"
     CDS             1396..2871
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101037.1"
                     /locus_tag="AMYAL_RS0133220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypsin-like serine protease"
                     /protein_id="WP_245193212.1"
                     /transl_table=11
                     /translation="MRRARRLGALAVSVLAATTALGSPASADTVQSFHTSLDPASVRES
                     VRYLVESYQVNEQEALRRLELQTDGVKLDELLRRDRGAEYGGMWLDQDKGQLVVAMTKP
                     AAAEPYLKAMPVRAAVRTQQVQHSLQQLTAAKERVAAKVGAGPEAVYLPSVSESENRVV
                     LWERDWVAQEKAAVRAAVDVVATETNTARKAAAAESGMVVSRVLKNPNALSTPNVDLGF
                     CHPLYCTNYGPMRGGLRLDMKRDDGTWGGCTSAFNLRSTGGGFPGKGWVLTAGHCMRTK
                     TNNTPTQHNGNDVLQQHGIEKSSYPYDYAALPYVNDAASTKWLEGQTGRNRVLKYCRNG
                     GMDSNGDTPCGAQATSVDEYITGARKLADIKAGYVVCASGTASSAVNYPDSVDSGAGAG
                     YLVGTRCGRVLSTDVGINTDLCARPGDSGGPLFSQADHAALGILIGNQQSRSGPCQAGE
                     LNNYAPIETITTDLSERIAGKGSQFAVITTPNG"
     misc_feature    1576..1578
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2937..3416)
                     /locus_tag="AMYAL_RS0133225"
     CDS             complement(2937..3416)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032716.1"
                     /locus_tag="AMYAL_RS0133225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_245193213.1"
                     /transl_table=11
                     /translation="MTELYRSAEIAGSTEAVTHAGWHPGARLRAGTANGRLLAYHDSGV
                     EAECIFREGERTLFNIMSTGYGRDTTESGFAVWSSRPGVLGAIDTGVSRVEVADADGVV
                     VQADIVDHTFAVDVDLGPEPRTVDEVFAPWDPPELTVRVYAEGDTLRYEGPLLTS"
     gene            3713..3964
                     /locus_tag="AMYAL_RS0133230"
     CDS             3713..3964
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032717.1"
                     /locus_tag="AMYAL_RS0133230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020635612.1"
                     /transl_table=11
                     /translation="MTAQRTITEEIGEIGVWLMGEFGGRVPAAVINRVLNASKRDLEGR
                     IDPEEFGEMFHALCRFRLQRIVAAEQRITVKIPGARPS"
     gene            complement(3936..5396)
                     /locus_tag="AMYAL_RS0133235"
     CDS             complement(3936..5396)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334393.1"
                     /locus_tag="AMYAL_RS0133235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_020635613.1"
                     /sec_met_domain="Aldedh (E-value: 1.7e-150, bitscore:
                     500.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITNDRLFIGSEWATPSDPARLDIVSPHDQSVLGRVVQALPADID
                     RAVAAARTAFDEGPWPRTSPEERIAVLRRLNALREARVDEIAALISAENGSALWFTRAG
                     QPGVGRLAVSYLKAAEEFGWEETLTPSDPAAPFRSIVRREPIGVVAAIIPWNSPFSASL
                     AKVIPALLAGNTVVLKVSPENSLSMSLLADLLAEAGLPAGVISVLPADRETSEYLVKHP
                     GVDKIAFTGSTAAGRRIASLAGAQLKRVSLELGGKSAAVILSDAVLPDVIAGLKFGSLL
                     NNGEACIAQTRILAPRSRYDEIVAGLKEMIESLVVGDPADETTFIGPMVRPGQQQRVRD
                     YIELGIAEGARLVTGGPEIPTGLDKGNYVTPTLFADVDSTMRIAKEEIFGPVLVVIPYD
                     DEDDAVRIANDSEYGLSGGVWSADEEHALAVARRMRTGTVTVNGAPIGFDGPFGGFKAS
                     GIGREYGAAGLAQYVELKTVTTGERRGS"
     gene            5475..6014
                     /locus_tag="AMYAL_RS0133240"
     CDS             5475..6014
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223304.1"
                     /locus_tag="AMYAL_RS0133240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_020635614.1"
                     /transl_table=11
                     /translation="MRADAARNLEAVLKTGALMLARDPSASISAIAAEAGVDRRTVYRR
                     FASREDLLAAIYDSRLTAVEKVVRTARLTETPVPVALHRYVEGIIEVNRAWPVELTRMR
                     AEPSIQDRRNRLTAEVDTFLRRATDEGFLRADIPDGWASRLLIQLLHLASREEMDTPRA
                     ADLLVGTFLGGVGVHS"
     gene            6190..7287
                     /locus_tag="AMYAL_RS0133245"
     CDS             6190..7287
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334395.1"
                     /locus_tag="AMYAL_RS0133245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ionic transporter y4hA"
                     /protein_id="WP_026467648.1"
                     /transl_table=11
                     /translation="MAASRRRFPVSWTTVMPVLAIVVLALSWGRDLGPVPVAIVAVALG
                     GTVLAAVHHAEVVAHRVGEPFGSLVLAIAVTVIEVALIVTMMSSGGPEAGTLARDTVFA
                     AVMITMNGIAGISLMVGARRYGETHFNPEGSGGALATVATLASVTLVLPTFTTSTPGPA
                     FNSTQLTFAAVASLLLYGLFVLTQTVRHRDFFLPVDSEGSVKEEDHAEPPSSKAALTSL
                     GLLLIALVAVVGLAKVESPAIEAGVRAAGFPQSFVGVVIAMLVLLPETLAATRAARRDR
                     MQTSLNLAYGSAIASIGLTIPTIALASIWLDGPLLLGLGATHIVLLALTIAVSVLTVVP
                     GRATRLQGGVHLVLLASFLVLAINP"
     gene            7342..9333
                     /gene="ligA"
                     /locus_tag="AMYAL_RS0133250"
     CDS             7342..9333
                     /EC_number="6.5.1.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635616.1"
                     /locus_tag="AMYAL_RS0133250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent DNA ligase LigA"
                     /protein_id="WP_020635616.1"
                     /transl_table=11
                     /translation="MNARDRIQELADQIVVLRDAYYRGSPKVADADYDAIEDELRGLIE
                     ANPELTPDPNPLDQVGAPAVLHAPIRHSRPMLSLEKATKPEQVEAFFARFPGQPVVVMP
                     KLDGLSLALVYENGRLARAITRGDGTTGDDVTMLVRALTDGVPDKVDAPGRVEVRGEAV
                     MLRSTFAAYNKVHPDKPLINPRNAAAGTLRAKDPATVAERRLQFFAFDLSTEPDSAETD
                     LDSALRTLGFAAADMRHCADAEAAQAVITTIEQQRNDLDYDLDGAVLRLADRDAYAAAG
                     TRSSSPRGALAFKFAAEEKTTVLADVVWDVGKTGKIAPVAWLEPVFVGGTTVTRATLAN
                     QEVIRARGIKIGDTVLVRRAGDVIPFVAGVLDAAKRTGEEREIVPPSVCPSCEEPLTEQ
                     GNSRELFCTNVACPAQTVRRLIHWASRAAADIDAIGGVWIERLAEAGILEHPSDFYRLT
                     KETLLEFDRIGDVSATRMIESIDASRAVGLRRALIGLAIPMASEGTAARLCRAGFGSLE
                     AVADAGEEGLVAVEDIGPKVAASLIEHLTRLRPELERLREAGVSLDVRDEDLPPVVAAG
                     APLEGKTVVVTGSISDPRSGEKVPRPTFQRLCERAGATIASSVSASTDLLITGADVGAS
                     KLTKAEKLEVEVVDQGVIWGQLIEAGVV"
     gene            complement(10001..11146)
                     /locus_tag="AMYAL_RS0133255"
     CDS             complement(10001..11146)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032722.1"
                     /locus_tag="AMYAL_RS0133255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_020635617.1"
                     /sec_met_domain="T1TS (E-value: 6.6e-53, bitscore: 179.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQGALATLLAGPRGLGTSAARLAARLTAVSPAVEETPPPEAPA
                     LDPTYAYRPWGDGSAPPLYVPVTERINVPLADEVDRRLIGWAGECGFDEGEREQIGKAG
                     FGRLVMLAHPDCEDPDKLLISAKLNAAWWAADDLYADDTSLGAVPAELPPKLALAMAAM
                     DPVPSLGEFSRDLDETLRSDRVLVALNSGTEYLRRNGTAAQVNRVCYSTFAMFVSWSAY
                     AAWRHSGKYPPAWEYLAARQHDSFYTSMTLIDVLGGYELTSNLYYDPRVREAAIQAGTA
                     SVLVNDVHSVAKDLEDESPPCNAVLLIADDRKCSIEEATAITVELHNDVVRDFQAAHEK
                     LSVVPSLELQRFLRGLRGWMGGGFEWHSTSSRYKVVSGKDG"
     misc_feature    complement(10088..10090)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11172..12035)
                     /locus_tag="AMYAL_RS0133260"
     CDS             complement(11172..12035)
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032723.1"
                     /locus_tag="AMYAL_RS0133260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_020635618.1"
                     /transl_table=11
                     /translation="MTIARTPAPAKVLRTEYQKSVASYWNKEKDPVNLRLGDVDGLYHH
                     HYGVGEVDWSVLEGPESTRDERIIAEMHRLETAQADVLLDHLGDVKPDDWLLDAGCGRG
                     GSSIMANARFGCHVDGISISEKQVEFANHQADIRGVSDKVGYHFRNMLDTGFETGSRKA
                     IWNNESTMYVDLHELFAEHARQLEFGGRYVTITGCYNDVTGGRSKAVAQIDQHYTCNIH
                     PRSQYFKAMTANDLVPISVVDLTADTIPYWELRAKSSVATGVEKPFLDAYREGSFHYLL
                     IAADRV"
     gene            complement(12089..13477)
                     /locus_tag="AMYAL_RS0133265"
     CDS             complement(12089..13477)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334401.1"
                     /locus_tag="AMYAL_RS0133265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_020635619.1"
                     /transl_table=11
                     /translation="MTATTPEADRRLSLGPAAARNLATTTKTRPQMQSITPRWLLKMLP
                     WVEATGGTFRVNRRLTYAIGDGRVSFTNVGTEVRVVPQELAELALLRGFDDEDTLTALA
                     DRFVQHEYQPGETIVSHGSPLDEVVLVAHGKVAKVAPGEYGAEAAIGSMADGDHFGDEM
                     LAGIDRNWPFTVKAVTPVIVLTLRADDFADLNGRSEALRRHVQDMLAHKGKPQNAKGES
                     EIGMSSGHDGEPLLPGTFVDYEISPREYDLAVAQTALRVHTRVTDLYNGPMDQFDEQLR
                     LTIAALRERQEYDLINNREFGLLHNADLKSRFQTRSGPPTPDDMDELVSRRRKTKFFLA
                     HPRAIAAFGRECTRRSLYPEGTTVDGKVVAAWRGVPLLPCDKIPITENGTSSILAMRTG
                     VDDNGVIGLHQTGLPDEYEPGLNVRFDGISDQAVASYLVSTYYSAAVLVPDALGVLENV
                     EVAR"
     gene            complement(13474..14895)
                     /locus_tag="AMYAL_RS0133270"
     CDS             complement(13474..14895)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159827.1"
                     /locus_tag="AMYAL_RS0133270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_020635620.1"
                     /transl_table=11
                     /translation="MTVTESGTSAEGVQGSENPQLSLGRAAARNLATTTKSVPQMQGIS
                     SRWLLKMLDWVQVNGGAYRVNRRLNYAVGDGRVTFSKAGTEVSVIPAELGELKPLKGYD
                     DEEVLAELARRFEQQEVAAGDVLVEFGHRADRVYLIAHGKITKTGPGPYGDETALGVVK
                     DGDYFGGQALVADDGIWEFTAKAATACTVLTLTRQDFERVLEQSESLQAQIEQTSQDTG
                     RSNDFGEAEIDISSGHDGEPLLPGTFVDYETSPREYELSVAQTVLRVHSRVSDLYNQPM
                     DQTEQQLRLTIEALRERQEHEMINNTDFGLLHNADFTQRIATRTGPPTPDDFDDLLALV
                     WKEPGFFLAHPRTIAAFSRECSKRGIYPTGADLGGHKVPSWRGVPILPCNKIPVSQTST
                     SSVLLMRTGEQNQGVVGLRQIGLPDEYEPGLNVRFMGISEQAIISYLVSTYYSAAVLVP
                     DALAVLEAAELGREG"
     misc_feature    15072..15085
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.62"
                     /tool="antismash"
     gene            15391..15723
                     /locus_tag="AMYAL_RS0133280"
     CDS             15391..15723
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159818.1"
                     /locus_tag="AMYAL_RS0133280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_020635621.1"
                     /transl_table=11
                     /translation="MLTCETQGAALARLGRALADPNRCRILVALLDGVNYPGQLADQLG
                     LSRSNVSNHLACLRGCGLVVATYEGRQVRYALADAHLARALRELVQVVLAVDTTEACVD
                     DAEVLR"
     gene            15726..16373
                     /locus_tag="AMYAL_RS0133285"
     CDS             15726..16373
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159817.1"
                     /locus_tag="AMYAL_RS0133285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation transporter"
                     /protein_id="WP_051137582.1"
                     /transl_table=11
                     /translation="MESTSCVDGCCTAKSTLDPDRRAVLSRRVRLLVAATITYNVIEAV
                     VAISAGTIASSTALIGFGLDSVIEVASATAVAWQFAGKDPEARERTALKVIAVSFFALA
                     AYVTVESIRTLFGADPAGHSTVGIVLAAVSLLVMPFLSHAQRRAGRELGSASAVADSKQ
                     TLLCTYLSGVLLVGLLLNSLLGWYWADPLVALVIAAVAIKEGREAWRGEHCC"
     gene            16384..16995
                     /locus_tag="AMYAL_RS0133290"
     CDS             16384..16995
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032728.1"
                     /locus_tag="AMYAL_RS0133290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_020635623.1"
                     /transl_table=11
                     /translation="MTRTVRWNRYWDGKSRNYDREMQFLDRKLFGDSRAWACGQADGDV
                     LEVAVGTGLNLPLYPEGVMLTGIDLSDGMLAIARARAERLGHPVTLRRADAHDLPFEAG
                     SFDTVVCTLGLCAIPDDGKALREMTRVLRPGGRLVLLDHVASSSRVVRGLQWLAEKVTV
                     PMAGEHFLRRPLDKIGGLGLTVEHRERFKLGLVERLVARK"
     misc_feature    complement(16404..16424)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.5"
                     /tool="antismash"
     gene            complement(17003..17572)
                     /locus_tag="AMYAL_RS0133295"
     CDS             complement(17003..17572)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635624.1"
                     /locus_tag="AMYAL_RS0133295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_020635624.1"
                     /transl_table=11
                     /translation="MTAPTGRRERKKAATRQKIAETALRLFLERGYDEVGIREVAAEAD
                     VAVTTLFSHFASKEALVFEQDADFEQGLTRAVTERAPDEPLIPALRRQVHAMVRHCTAD
                     GAAPIFRMIDESPALRDYEDSMRLRHAESLAAAIAADPDLSQSATACRTIARFVIDAYS
                     LGREAADPEAAVDEIFRMIEAAWEAA"
     gene            17643..18536
                     /locus_tag="AMYAL_RS0133300"
     CDS             17643..18536
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-182). E-value: 2.2e-34.
                     Score: 110.9. Matches aSDomain:
                     nrpspksdomains_AMYAL_RS0133300_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_158889528.1"
                     /locus_tag="AMYAL_RS0133300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_020635625.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-08, bitscore: 33.6,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.8e-08, bitscore:
                     32.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVIFTEFGGPEVLQLVDAEAPHAGPGQVRIAVRAAGVNPVDWR
                     IREGQVLGAHPTVLPSGVGIDAAGIVDEVGEGVTGVEVGDSVFGEGSSTYAEFAVLPAW
                     ARMPANLSFEEAAGYPSVVETALRLIREVDVRPGQTLLVSGASGGVGSAVLQIARERGI
                     TVIGTAGAANQDYLRGLGAVATTYGEGWVERVRRLGRVDAALDLAGSGVIGELVELTGD
                     PGKVLSIADLGAPEFGVRFSGVAGSVPDALAEAVDLISRGKLHIPVEKSYSLTDAAAAH
                     ADSHAGHARGRRVIVV"
     aSDomain        17685..18188
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMYAL_RS0133300_PKS_ER.1"
                     /evalue="2.20E-34"
                     /label="AMYAL_RS0133300_PKS_ER.1"
                     /locus_tag="AMYAL_RS0133300"
                     /protein_end="182"
                     /protein_start="14"
                     /score="110.9"
                     /tool="antismash"
                     /translation="LQLVDAEAPHAGPGQVRIAVRAAGVNPVDWRIREGQVLGAHPTVL
                     PSGVGIDAAGIVDEVGEGVTGVEVGDSVFGEGSSTYAEFAVLPAWARMPANLSFEEAAG
                     YPSVVETALRLIREVDVRPGQTLLVSGASGGVGSAVLQIARERGITVIGTAGAANQDYL
                     RGLGA"
     CDS_motif       18054..18116
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMYAL_RS0133300_0001"
                     /evalue="1.20E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="AMYAL_RS0133300"
                     /protein_end="158"
                     /protein_start="137"
                     /score="14.8"
                     /tool="antismash"
                     /translation="GQTLLVSGASGGVGSAVLQIA"
     gene            complement(18543..19028)
                     /gene="rraA"
                     /locus_tag="AMYAL_RS0133305"
     CDS             complement(18543..19028)
                     /GO_function="GO:0008428 - ribonuclease inhibitor activity
                     [Evidence IEA]"
                     /GO_process="GO:0051252 - regulation of RNA metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rraA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159804.1"
                     /locus_tag="AMYAL_RS0133305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease E activity regulator RraA"
                     /protein_id="WP_020635626.1"
                     /transl_table=11
                     /translation="MIDSFTTADLVDEHGDRLHVCDTQFRQFGGHRKFAGPIRTVSCHE
                     DNGLVKKLLATPGEGGVLVVDGGGSLHSALTGDMIAKSAVDNGWAGVVVHGAVRDSAEL
                     AGLPLGVKALGTNPRKSSKAGVGAVDVPVGFGGVTFTPGDTLYSDDDGVVILPATTA"
     gene            complement(19025..19564)
                     /locus_tag="AMYAL_RS0133310"
     CDS             complement(19025..19564)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159803.1"
                     /locus_tag="AMYAL_RS0133310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020635627.1"
                     /transl_table=11
                     /translation="MQLYPLQEGEEVLWTGAPQRPRKWFPEHIQMVALAVPFVFLFFVW
                     VEHSGLPPFIGLFAAFFILFHQRLSDRRSRENVLTYMVTNQRIIFVANWQAGTEFRWVW
                     FRYLQHPPEVKVDETGVGTVTYGSRWGRSRVRSNELRGAWAAPVLELRAIPDARRVADL
                     IEEARNWLIATYTQAP"
     gene            complement(19609..20208)
                     /locus_tag="AMYAL_RS0133315"
     CDS             complement(19609..20208)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159802.1"
                     /locus_tag="AMYAL_RS0133315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_020635628.1"
                     /transl_table=11
                     /translation="MTRLTRAEQQRRTHEHLLGAGRQVFLRRGFLAATVEEIAADAGYT
                     RGAVYKHFGGKEGLWLAIIRADADGHLQGLREALARAATREEVIAALNPVDVADKDAAK
                     WSAAAAEVLAATAQQPETATLVAAIQRRHDDEVVALLTEHTRRLRLEPALPLDQAVVML
                     GALGIGLALRQSVAPAADPAAILAHVLETMIPIKAT"
     gene            20270..20506
                     /locus_tag="AMYAL_RS49540"
     CDS             20270..20506
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMYAL_RS49540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_143267825.1"
                     /transl_table=11
                     /translation="MELLAPVAAFLSLPLFLAGFAWYAVRARSRGVSQSLLAPIEEIWD
                     PIAHKTNIEIQIEAERSPETPSPGDPPEPMWRP"
     gene            complement(20519..21139)
                     /locus_tag="AMYAL_RS0133325"
     CDS             complement(20519..21139)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159796.1"
                     /locus_tag="AMYAL_RS0133325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_020635630.1"
                     /transl_table=11
                     /translation="MKIAVVGAAGMTGSRVVTEAISRGHHVTAVFRRTPPDSRHPDVEI
                     VRGDITDVGRMSEVFGGVDAVVGATRPAPGAEDTVAATAKALLDAAAGTRVLVVGGAGP
                     LRSPSGGLVIDDPVFVPLSWRTIASASTTQLQVCEAHDGDWVYLSPPAMLEPGIRTGTY
                     RRGTTTILTAEDGSSRISAEDLAVAIVDELENPGGDRHFTVGY"
ORIGIN
        1 caccgtggcg aacctgcgag tcgcggcggg cttcggcgcg cacgactccg gcctgcgggc
       61 gctggtgacg gaactcggcg aaggcagcgc gcgattccgg gagctgtggg agacccatca
      121 ggtacgcggc aagacccgtg aacccaaaca tctcgtgcat cccgacgtcg gtccgctcac
      181 cctcacctat caagcgttcg acgtgcgcgg tgcccctggc cagcagctga tcatctatca
      241 cgccgaaccg gccacgccga gcgctcacgc cctcgcgctg ctgagcagtc ttcacgccac
      301 gcgtgcggcc gacgcctgac ccgcgagaac atgtccggag tgtgaccacc cgatcagagc
      361 agtcactcgc tgttggtgag ccaagtgcca caccatggcg cacccggccg cctgttcgag
      421 tgaacccacc gtgaacatcg atgctcggat ttggtcgaag ttgaacgcaa tcggtggttg
      481 cgatcagtat ttttcacacc gcggaagcaa cgcgcacgac ttcgacaata tgcttctcca
      541 cctgcgcgga tcagtgcgat gccgcaagca gtgacgacca gggaaggcaa gccatcggac
      601 cgtcgagccc gtctggcggc actcgtccat tcggcgccac caactacttt tagtagtttc
      661 cagagtcacc cagaccgctg agcgacgcgt gcataccgtt cagcgcgaca cacgcagtac
      721 tactgaacgg tcacagtctg ctttcgccaa gatgttctca gccgcaccgg gtcaagaacc
      781 ggtaacgcgc gcgtggcccc ctgctgtcac aggaggccac gcggatgtcc attcgcccgc
      841 tcgctagaac aaggacagga cgccgtgacc ttacagcctg ataatgcgac gacaccagac
      901 aacggcccgc cccgacgggt caaagtcgtc atcgagcact tcgaaaagcc acctcgccga
      961 gtcgccacct ccgcggagat gatccgtgcc gcgcggcctc tcctgaggtg ccccggacgc
     1021 caccgcaaag tgcagacccg cgacagctgg ctctgcctgg cgatggcggt cctcgccggc
     1081 tgggctccga ccctgcggat gtgcctcctg ctgacgatcg gcggcggaat cgtcgtcggc
     1141 gtcgtcagga tcagcacgcc tcaggtcggc gcgtcggcgg gaacctgcgt cggtctgctg
     1201 acccttttcg gcgcctggat cgtcaaagcc cgccaaggga agcagcgtcg ggagccgagt
     1261 ctgtagctcg aaggtcgccc cgtgcctgcc ggatcgacgg caggcacggg gcgcggctct
     1321 gtcgaaaact gcccacacct gccggtcgac ctccggttaa atgatcgcga agtccccgac
     1381 atgtgaggag atcttgtgcg gagagctaga agactggggg ccctggccgt ttcggtgctg
     1441 gcagcgacca cggcactggg cagtccggcg tcggccgaca ccgtgcagtc gttccacaca
     1501 tcgctcgacc ccgcttcggt gcgggagtcg gtgcggtacc tggtcgagag ctaccaggtg
     1561 aacgagcagg aggcattacg ccgtctggag ttgcagacag acggcgtcaa gctggacgag
     1621 ctgctgcgcc gcgatcgcgg cgccgagtac ggcggcatgt ggctcgacca ggacaagggc
     1681 cagctggtgg tggccatgac caaacccgcg gcggccgagc cgtatctcaa ggcgatgcct
     1741 gttcgtgccg ccgtgcgcac gcaacaggtt cagcattcgt tgcagcagct cacagccgcg
     1801 aaggaacgcg tcgcggccaa ggtcggcgcg ggaccggaag cggtctacct gccgtcggtc
     1861 agtgagtccg aaaaccgtgt cgttctgtgg gaacgcgact gggtggcaca ggagaaggcg
     1921 gccgtgcgtg ccgccgtcga cgtcgtggcc accgagacga acaccgctcg caaggccgcg
     1981 gcggcggaat ccggcatggt cgtctcccgc gtgctgaaga acccgaacgc gctgtccacg
     2041 ccgaatgtgg atctgggttt ctgtcatccg ctctattgca cgaactacgg cccgatgcgc
     2101 ggcggactcc ggttggacat gaagcgggac gacggcacct ggggcggctg caccagcgcc
     2161 ttcaacctgc ggtccaccgg cggcggtttc cccggcaagg gctgggttct gaccgcgggt
     2221 cactgcatgc ggacgaagac caacaacacg ccgacgcagc acaacggcaa cgacgtgctg
     2281 cagcagcacg gcatcgagaa gagctcctac ccgtacgact acgcggccct gccgtacgtc
     2341 aacgacgcgg cgtcgacgaa gtggctcgaa ggccagaccg gccgcaaccg ggtgctgaag
     2401 tactgccgca acggtggcat ggacagcaac ggtgacaccc cgtgtggtgc tcaggccacc
     2461 tcggtcgacg agtacatcac cggcgcccgc aagctcgccg acatcaaggc cgggtatgtc
     2521 gtctgcgctt ccgggacggc ttcgagcgcc gtgaactacc ccgattccgt cgacagcggc
     2581 gcgggcgccg gctacctcgt cggtacccgc tgcggccggg tcctgtccac ggacgtcggc
     2641 atcaacaccg acctgtgcgc ccgtccgggc gacagcggcg gaccgctgtt cagccaggcc
     2701 gaccacgcgg cgctgggcat cctgatcggc aaccagcagt cccggtcggg cccctgccag
     2761 gccggtgagc tgaacaacta cgcgccgatc gagacgatca ccaccgatct cagcgagcgg
     2821 atcgccggca agggatccca gttcgcggtg atcacgactc cgaacggctg atcctctgag
     2881 tacgtgaagg cccccttcat tgcttctagc gcaatgaagg gggccttcac gtacgtctag
     2941 ctggtcagca aaggaccttc gtatcgcaac gtgtcgccct cggcgtacac ccggaccgtc
     3001 aactccggcg ggtcccacgg cgcgaacacc tcgtcgaccg tccggggctc gggtcccaga
     3061 tccacgtcca cagcgaaggt gtgatccacg atgtcggcct ggacgacgac cccgtccgcg
     3121 tcggcaacct ccacacggct caccccggtg tcgatcgcgc ccagcacacc cggccgcgaa
     3181 ctccacaccg cgaacccgct ctcagtggtg tcgcgcccgt acccggtgct catgatgttg
     3241 aacagcgtgc gctccccctc ccggaagatg cactccgctt cgacgcctga atcgtggtaa
     3301 gccagcaatc gcccgttcgc ggtgcccgcc cggagccggg cccccggatg ccacccggcg
     3361 tgcgtcaccg cctccgtcga ccccgcgatc tccgcggacc ggtaaagctc ggtcaaggtc
     3421 gtcagctccg ctatccactg ctcgactact tcatccttcg ctggggccac tacgcgtgtg
     3481 ccttcctctc tgactgtcca caatggtcga tatcgaggct gacacacgcg tgaaccgatc
     3541 gcatcggggt ttccccggag atcgcatcgg caggctgcac ggttccgtgc aaccgaggac
     3601 ggttaggccg agtagagcaa tctcgcggat ttcccgtcat ggcgtttccg gtcgcacgtc
     3661 gcgattgcgc cggggcaagc ccggcgcaac ccgacgcaga ggggtaaggc tgatgaccgc
     3721 gcagcgcacg atcacggagg agatcggcga aatcggtgtc tggctgatgg gcgagttcgg
     3781 tggccgcgtg cccgcggccg tgatcaaccg ggtgctcaac gcgagcaaac gcgacctgga
     3841 agggcgcatc gaccccgagg agttcggcga gatgttccac gcactctgcc ggttccggct
     3901 tcagcggatc gtggcagcgg aacagcggat cacggtcaag atccccggcg ctcgcccgtc
     3961 gtgacggtct tcagctcgac gtactgagcg aggcccgccg caccgtattc gcgaccgatg
     4021 ccactggcct tgaacccgcc gaaggggccg tcgaagccga tcggcgcgcc gttgacggtg
     4081 acggtcccgg tgcgcatccg ccgcgcgacc gcgagtgcgt gctcctcgtc ggcggaccag
     4141 acaccgccgg agagcccgta ctccgagtcg ttggcgatgc ggacggcgtc gtcctcgtcg
     4201 tcgtagggaa tgacgacgag gaccggcccg aagatctcct ccttggcgat gcgcatcgtg
     4261 ctgtcgacgt cggcgaacaa ggtcggcgtg acgtagttgc ccttgtccag gcccgtcggg
     4321 atttcgggac ctccggtgac cagccgcgcg ccttcggcga tgccgagttc gatgtagtcg
     4381 cgcactcgct gctgctgacc gggccgcacc atcgggccga tgaaggtcgt ctcgtcggca
     4441 gggtcgccga cgacgagaga ctcgatcatc tccttgagtc cggcgacgat ctcgtcgtac
     4501 cggctccggg gcgccaggat ccgcgtctgc gcgatgcacg cctcgccgtt gttgagcagg
     4561 gatccgaact tcaagccggc gatcacgtcc ggcaggacgg cgtcggacag gatcacggcc
     4621 gcggatttcc cgcccagttc caggctgacc cgcttcagct gtgcaccggc cagcgacgcg
     4681 atgcggcgac cggcggcggt cgaaccggtg aacgcgatct tgtcgacgcc ggggtgcttc
     4741 accaggtact cgctggtctc ccggtccgcg ggaagcacgc tgatcacccc ggcgggcagc
     4801 ccggcctccg ccagcagatc cgcgaggagg ctcatgctga gcgagttctc cggcgagacc
     4861 ttgaggacga ccgtgttccc cgcgagcagt gccgggatga ccttggccag cgacgccgag
     4921 aacggcgagt tccacgggat gatcgcggcg accaccccga tcggctcccg tcgcacgatc
     4981 gagcggaacg gcgcggccgg gtccgaaggc gtgagcgtct cttcccagcc gaactcctcc
     5041 gccgccttca gatacgagac ggccagacgt cccactccgg gttgcccggc gcgggtgaac
     5101 cagagggccg agccgttctc ggccgagatc agcgcggcga tctcgtccac gcgggcctcc
     5161 ctcagcgcgt tcagccgccg gagcacggcg atccgctcct ccggcgaggt ccgcggccat
     5221 ggcccttcgt cgaacgcggt cctcgcggcg gcgacggcgc ggtcgatgtc ggcggggagg
     5281 gcctggacga cgcggcccag aaccgactgg tcgtgcgggg acacgatgtc cagccgcgcc
     5341 ggatcgctcg gcgtcgccca ctcgcttccg atgaagagcc tgtcgttcgt gatcatcttt
     5401 acgcctctct aactgtcaca tcaatgtagc acttatggcg gttaacgaca cagcagcgtg
     5461 atacattccc ggacatgaga gctgatgcgg cgcgcaatct cgaagccgtc ctgaagactg
     5521 gcgcgctgat gctcgctcgc gacccgtcgg cgagcatcag cgcgatcgcc gccgaagcag
     5581 gtgtcgacag gcgcaccgtc taccggcgtt tcgcctctcg ggaagacctc ctggcggcca
     5641 tctacgactc ccggctgacc gcggtcgaaa aggtcgtccg caccgcccgg ctcaccgaga
     5701 cgccggtccc cgtcgccttg catcgctacg tcgaaggcat catcgaggtc aaccgcgcct
     5761 ggccggtcga gctgacccgc atgcgcgccg aaccgtccat ccaggaccgc cgaaaccggc
     5821 tcacggccga ggtggacacg ttcctccggc gcgccacgga cgaaggcttc ctccgcgcgg
     5881 acatcccgga tggctgggcg agccgcctgc tgatccagct cctccacctc gcctcgcggg
     5941 aggagatgga cacaccgcgc gccgcggacc tgctcgtcgg caccttcctc ggcggagtcg
     6001 gcgtccactc ttgagtggta aggcaaacgt gtcttgctcg acccttcgcg cgtctgtcgg
     6061 cttcgggcgt cgagtgcctc gtgcgcctcg ctggggacgc cccgcctgct cgtactcctg
     6121 ctaagaactt cgtcaccctc caccccacat ggagcggcga tgtcacgcag ggtgtgcgaa
     6181 ggtgacgtca tggcagcttc gcgcagacga ttccccgtgt cctggaccac cgtcatgccg
     6241 gtcctcgcca tagtcgtgct ggcgctgagc tggggccgcg atctgggccc ggtgccggtc
     6301 gccatcgtcg cggtcgccct cggcgggacg gtgctggccg cggtgcacca cgccgaggtc
     6361 gtcgcgcatc gcgtcgggga acctttcggc tcgctggtgc tggcgatcgc ggtcacggtc
     6421 atcgaggtcg cgctgatcgt cacgatgatg tcctccggcg gccccgaagc cgggactctg
     6481 gccagggaca cggtgttcgc cgcggtgatg atcaccatga acggcatcgc gggcatttcg
     6541 ctcatggtcg gcgcccggcg ctacggcgaa acgcacttca acccggaagg cagcggcggc
     6601 gcactcgcca ccgtggcgac actcgcttcc gtcaccctcg tgctgccgac gttcaccacc
     6661 agcacccccg gccctgcctt caacagcacc cagctcacct tcgccgccgt cgcctcactg
     6721 ctgctctacg gcctcttcgt gctcacccag accgtgcgcc accgcgactt cttccttccg
     6781 gtcgacagcg agggctcggt caaggaggaa gaccacgccg aaccgccgag cagcaaggcg
     6841 gcactgacca gtctcggcct gctgctgatc gccctggtcg ccgtcgtcgg cctggcgaag
     6901 gtcgaatccc ccgcgatcga agcaggtgtc agggcggcgg gcttcccgca gtcgttcgtc
     6961 ggcgtcgtga tcgccatgct ggtgctgctg ccggaaaccc tggccgcgac gcgggccgcc
     7021 cgacgcgacc ggatgcagac cagcctgaac ctcgcctacg gttcggcgat cgcgagcatc
     7081 gggctcacca tcccgaccat cgcgctggcg tcgatctggc tggacggacc gctgctgctc
     7141 ggcctcggcg cgacccacat cgtgttgctc gcactcacga tcgcggtcag cgtgctcacc
     7201 gtcgtccccg gccgcgcgac ccggctgcag ggcggcgtcc acctggtgct gctggcctcg
     7261 ttcctggtgc tcgccatcaa cccgtgacac gggtcctctt cggacacggt tctgtcggtg
     7321 gtcacgggta atctctgccc cgtgaacgct cgggaccgca tccaagaact cgccgatcag
     7381 atcgtcgtcc ttcgcgacgc ctactaccgg ggctcgccga aggtggccga cgccgactac
     7441 gacgcgatcg aagacgagct gcgggggctc atcgaggcca accccgagct gaccccggac
     7501 ccgaacccac tcgaccaggt cggcgcgccc gccgtcctgc acgcgcccat ccggcactcg
     7561 cgcccgatgt tgtcgctgga gaaggcgacc aaacccgagc aggtcgaggc gttcttcgcc
     7621 cgcttccccg gacagccggt ggtcgtcatg ccgaaactgg acggcctgtc gctggccctg
     7681 gtctacgaga acgggcggct cgccagggcg atcacccgcg gcgacgggac gaccggcgac
     7741 gacgtgacca tgctggtgcg ggcgctgacc gacggcgtcc ccgacaaggt cgacgcgccc
     7801 ggccgggtcg aggtccgcgg cgaggccgtc atgctccggt ccactttcgc cgcgtacaac
     7861 aaggttcacc cggacaagcc gctgatcaac ccgcgcaacg ccgccgccgg gaccctgcgc
     7921 gccaaggatc cggccactgt cgccgagcgg cgtctccagt tcttcgcctt cgatctctcc
     7981 acggaaccgg acagcgcgga aaccgacctc gacagcgcgc ttcggacgct cgggttcgcc
     8041 gcggccgaca tgcggcactg tgcggacgcc gaggccgcgc aggccgtcat cacgaccatc
     8101 gagcagcagc gcaacgacct cgactacgac ctcgacggcg ccgtgctgcg cttggcggat
     8161 cgtgacgcgt acgccgccgc cggaacgcgg tccagctcac cgcgcggcgc gctggcgttc
     8221 aaattcgccg ccgaggagaa gaccaccgtg ctcgcggacg tggtctggga tgtcggcaag
     8281 accggcaaga tcgcgcccgt cgcgtggctg gagccggtgt tcgtcggcgg gaccaccgtc
     8341 acacgggcga ccttggccaa ccaggaggtc atccgcgccc gcggtatcaa gatcggtgac
     8401 accgtcctgg tgcgccgcgc cggcgacgtg atcccgttcg tggccggcgt gctcgacgcc
     8461 gccaagcgca ccggcgagga gcgggagatc gtgccgccct cggtgtgccc gtcgtgcgaa
     8521 gagccgttga ccgaacaggg caacagccgg gaactgttct gcaccaacgt cgcctgcccc
     8581 gcccagaccg tccggcggct gatccactgg gcttcgcggg cggccgcgga catcgacgcg
     8641 atcggcgggg tctggatcga aaggctcgcc gaggccggga ttctcgagca cccgtcggac
     8701 ttctaccggc tcaccaagga aacgctgctg gagttcgacc gcatcggcga cgtctccgcc
     8761 acccgcatga tcgagtcgat cgacgcgagc cgagccgtcg gcctgcgccg ggcgctgatc
     8821 ggcctggcga tcccgatggc ttcagaaggc accgccgcgc ggctgtgccg agcgggcttc
     8881 ggctcgctgg aggctgtcgc ggacgcgggt gaagagggtc tcgtcgccgt ggaggacatc
     8941 ggcccgaagg tcgccgcgtc cctgatcgaa catctcaccc ggctgcgtcc cgaactcgag
     9001 cggctgcggg aagccggtgt ctcgctggac gtccgcgacg aggacctccc accggtggtc
     9061 gcggcaggcg cgccgctgga gggcaagaca gttgtggtca ccggttcgat cagcgacccc
     9121 cgttctggcg agaaggtgcc gcgcccgacc ttccagcggt tgtgcgaaag ggcgggcgcg
     9181 accatcgcgt cctctgtctc ggcgagcacc gacctgctga tcaccggcgc cgacgtcggg
     9241 gcgagcaaac tcaccaaggc cgagaaactc gaagtcgagg tcgtggacca aggcgtcatc
     9301 tggggacagt tgatcgaagc aggcgtcgtt tagcagtggt ctcgtgagtg gtaaggctgg
     9361 ttctcaccgg ccttactcac gaggccccac tgccgggccg gccgcctcac gtgactggcc
     9421 ggacgacacg cgtgattgaa cggacgacac gcgtgtgcca acggacgact cgcgagtcgt
     9481 cccaccggac acgcgtgtcg tccatcccgt cacgcgtgtc gtcctgctgg acacacgaca
     9541 ccgccacccg cgcaccacag caggtaccta acacgccctt ggtcctaacc gtcctgaccg
     9601 ctcacgaccg ccgagagact gcgcggcccg gacacaggcc gcggtgtcgc gaaagccact
     9661 ttcgcgacgt ctgatgtccc gaaagtggct ttcgcgacac gatcgccggg tagcgaccgg
     9721 ggcacagggc aagcgcctca ggcgtgactc gcgtgacccg tccctgatca cgcatgaccg
     9781 cccacctcac ccgaacacga caccgccacc cgcacaccac aagcaggtac ctgaaacacc
     9841 cttggctctc accgtcctca ccactcacga gctggggtcc cgtgcggtct ggcggggagg
     9901 gcgtgttgcg aaagccactt tcgcaacctt caacgttgcg aacgtggctt tcgcaacacg
     9961 accagcggag cgcgtgcttg gaccgtcggc agggctggtt ctaaccgtcc ttaccactca
    10021 cgaccttgta gcgagagctc gtcgagtgcc attcgaaccc gccgcccatc catccccgca
    10081 gcccgcgtaa gaaccgttgc agctcaaggg aaggcaccac gctcagcttc tcgtgcgccg
    10141 cttggaagtc ccggacgacg tcgttgtgca actcgacggt gatcgccgtg gcctcctcga
    10201 tcgagcactt ccggtcgtcg gcgatcagca ggaccgcgtt gcacggtggc gactcgtcct
    10261 ccagatcctt ggcgaccgag tgcacgtcgt tgacgagcac ggacgccgtg cccgcctgga
    10321 tcgccgcttc ccggacccgc gggtcgtagt agaggttcga cgtcagttcg tagccaccga
    10381 ggacgtcgat caacgtcatc gaggtgtaga aactgtcgtg ctgccgggcc gcgagatact
    10441 cccaggccgg cgggtatttc ccgctgtggc gccaggccgc gtaggcgctc cagctcacga
    10501 acatcgcgaa ggtcgaataa cagacgcggt tgacctgcgc ggcagtcccg ttccgccgca
    10561 agtactccgt tccggagttc agcgccacca gaactctgtc actccgcaac gtttcgtcga
    10621 ggtcgcggct gaattcgccc aacgacggca ccgggtccat ggcggccatc gccaacgcga
    10681 gtttcggggg cagttccgcc ggcaccgcgc cgagcgaggt gtcgtcggcg tagaggtcgt
    10741 cggcggccca ccaggcggcg ttgagcttcg cggagatcaa cagcttgtcg gggtcttcgc
    10801 agtccgggtg ggcgagcatg accagcctgc cgaagcccgc cttcccgatc tgctcgcgct
    10861 ccccctcgtc gaaaccgcac tcccccgccc acccgatcag ccgccggtcg acctcgtcgg
    10921 cgagcggaac gttgatccgt tcggtgacgg ggacgtacag cggcggcgcc gacccatcac
    10981 cccacggccg gtatgcgtat gtcgggtcga gggcgggtgc ctccggcggc ggagtttcct
    11041 ccaccgccgg agaaacagcg gtcaaccgtg ccgccagccg ggcggcggac gtacccagtc
    11101 cgcgtggccc ggccagcaac gtggccagtg caccctgttc cgtcatcagt gtctccgatg
    11161 gtctcgcgag gtcagacccg gtccgccgcg atgagcaggt agtggaagct gccttcgcga
    11221 taggcgtcga ggaacggttt ttcgacccct gtcgccaccg aagacttcgc tcgcagttcc
    11281 cagtacggga tcgtgtcggc cgtcaggtcc accaccgaga tcggcaccag gtcgttggcc
    11341 gtcatcgcct tgaagtactg gctgcgcgga tggatgttgc aggtgtagtg ctggtcgatc
    11401 tgcgcgacgg ccttggaccg gccaccggtc acgtcgttgt agcagccggt gatggtgacg
    11461 tagcggccgc cgaactccag ctgtcgcgca tgctcggcga agagctcgtg gaggtccacg
    11521 tacatggtgc tttcgttgtt ccagatcgcc ttgcgcgaac cggtttcgaa gccggtgtcg
    11581 agcatgttgc ggaagtggta gccgaccttg tcggagacgc cccggatgtc cgcctggtga
    11641 ttggcgaact cgacctgctt ctccgagatc gagatcccgt cgacgtggca gccgaaccgc
    11701 gcgttggcca tgatgctgga cccgccgcgc ccgcagcccg cgtcgaggag ccagtcgtcc
    11761 ggtttgacgt cgccgaggtg atcgagcagg acgtccgcct gcgctgtctc caggcggtgc
    11821 atttcggcga tgatccgctc gtcgcgggtg ctctcggggc cttccagtac ggaccagtcg
    11881 acctcgccga ccccgtagtg gtggtgatac agcccgtcca cgtcacccag ccggaggttg
    11941 accggatcct tctccttgtt ccagtacgac gccaccgact tctggtactc ggtgcgcaga
    12001 accttggcgg gagcgggggt acgggcgatg gtcacgtggg tggtcctttc tggagcattg
    12061 ttgttcgttg tggtgacggg gcgaggggtc aacgcgcgac ctcgacgttc tccaggacac
    12121 cgagcgcgtc gggcacgagc acggcggccg agtagtaggt actgaccaga tagctggcga
    12181 cggcctgatc ggagatgccg tcgaagcgca cgttcaggcc cggctcgtac tcgtcgggca
    12241 ggccggtctg gtgcaggccg atcacgccgt tgtcgtccac gccggtccgc atggcgagga
    12301 tcgacgaggt gccgttctcg gtgatcggga tcttgtcgca gggcaggagc ggtaccccgc
    12361 gccacgcggc gaccaccttg ccgtcgaccg tggtgccttc cgggtacagg ctgcggcggg
    12421 tgcattccct gccgaaagcg gcgatcgcgc gcggatgggc gaggaagaac ttcgtcttgc
    12481 ggcgtcggct gacgagttcg tccatgtcgt cgggcgtcgg cggaccggac cgggtctgga
    12541 accgcgattt gaggtcggcg ttgtgcagta gtccgaactc gcggttgttg atcaggtcgt
    12601 attcctgccg ttcccgcagg gccgcgatgg tcagccggag ctgctcgtcg aactggtcca
    12661 tcggcccgtt gtagagatcg gtcacccgcg tgtgcacccg cagtgccgtc tgcgcgacgg
    12721 ccaggtcgta ctcgcgtggc gagatctcgt agtcgacgaa cgtgcccggc agcagcggct
    12781 caccgtcgtg cccggacgac atcccgatct cggactcacc cttggcgttc tgcggctttc
    12841 ctttgtgtgc cagcatgtcc tgcacgtggc ggcgcagcgc ctcggaccgg ccgttgaggt
    12901 cggcgaagtc gtcggcgcgc agggtcagca cgatgaccgg ggtgacggcc ttgacggtga
    12961 acggccagtt ccggtcgatg ccggcgagca tttcgtcacc gaagtggtcg ccgtcggcca
    13021 tgctgccgat ggccgcttcg gcgccgtact cgcccggcgc cactttcgcg accttgccgt
    13081 gcgcgaccag cacgacctcg tcgagcgggg agccgtggct gacgatggtc tcgccgggct
    13141 ggtattcatg ctgcacgaac cggtcggcga gcgcggtgag cgtgtcctcg tcgtcgaaac
    13201 cccgcagcag cgccagttcc gcgagttcct gcgggacgac ccggacctcg gtaccgacgt
    13261 tggtgaagct cacccgcccg tcgccgatgg cgtaggtcag gcggcggttg acccggaagg
    13321 tgccaccggt cgcctccacc cacggcagca tcttcagcag ccagcgcggc gtgatgctct
    13381 gcatctgcgg ccgcgttttg gtggtcgtcg ccaggttccg cgcggccgcg gggccgagac
    13441 tgagccgccg gtcggcctcc ggcgtcgtgg cggtcatcct tcgcggccga gttcggcggc
    13501 ttcgaggacg gccagggcgt ccggtacgag cacggcggcg gagtagtacg tgctgacgag
    13561 gtaggagatg atcgcctgct ccgaaatccc catgaagcgg acgttcaatc cgggctcgta
    13621 ctcgtccggc aggccgatct gacgcaggcc gaccacaccc tggttctgct cgccggtgcg
    13681 catcagcagt acggaactgg tgctggtctg gctcaccggg atcttgttgc acggcaggat
    13741 cgggaccccg cgccaggacg gcaccttgtg gccgccgagg tcggcgccgg tcgggtagat
    13801 gccgcgtttg ctgcactcgc ggctgaacgc ggcgatcgtg cgcggatgcg cgaggaagaa
    13861 gccgggttcc ttccacacca gggcgagcag gtcgtcgaag tcgtccgggg tgggcggtcc
    13921 ggtgcgcgtc gcgatgcgct gggtgaagtc ggcgttgtgg agcaggccga agtccgtgtt
    13981 gttgatcatt tcgtgctctt ggcgctcgcg cagcgcctcg atggtcaggc ggagctgctg
    14041 ttcggtctgg tccatcggct ggttgtagag gtcggacacc cggctgtgga cccgcagcac
    14101 ggtctgggcg acactcagtt cgtattcccg tggcgaggtc tcgtagtcga cgaacgtgcc
    14161 cggcaacagc ggctcgccgt cgtgaccgga ggagatgtcg atctcggctt cgccgaaatc
    14221 gttggaacgt ccggtgtctt gcgatgtctg ctcgatctgc gcctgcagcg attcggactg
    14281 ttcgagtacg cgctcgaagt cctgccgggt caaggtgagc acggtgcagg cggtggccgc
    14341 cttggcggtg aactcccaga tgccgtcatc ggcgacgagc gcctgcccgc cgaagtagtc
    14401 accgtccttg accacgccga gcgcggtctc gtcaccatag gggccggggc cggttttggt
    14461 gatcttgccg tgggcgatga ggtagactcg gtcggcccgg tgcccgaatt cgacgagcac
    14521 gtcgcctgcg gccacctcct gctgttcgaa gcggcgggcg agttcggcga gtacttcttc
    14581 gtcgtcgtat cccttgagcg gtttcagttc gcccagttcc gccgggatca cgctcacttc
    14641 ggtgcccgcc ttggagaacg tcacccgtcc gtcaccgacc gcgtaattga gccgccggtt
    14701 gacccgatag gcgccaccgt tgacctggac ccaatcgagc atcttcagca gccagcggga
    14761 cgaaatgccc tgcatctgcg gaacggattt agtcgtggtc gccaggtttc gcgcggcggc
    14821 ccgccccaaa ctcaactgcg ggttttccga cccctggaca ccttcggcgg aagtgcccga
    14881 ttcggtcacg gtcacagcaa ggtccaccct tcgatagtcg cttgagcaaa caagatccac
    14941 aaaccgtggc gtgccgtcat gccccgatgt gcggctccac ggggatcaac atagcaaggc
    15001 gctttgccta cacaagcgca ctttcaggta atgcgagaag gccacccgaa tgccgctttt
    15061 tccattgtgt gagaacacaa tttcccccat tactcgacgc tttaatgtgc ccacacaatc
    15121 ggtccagcga ctgttctgag gtgttatgcg aagccgtccg gaaactcctc ggagtgcccg
    15181 ttatgcgacc gttggagtgg gtgtgccacc ccctttcggg tcacctccgg ggccgtgctc
    15241 ggcgacgtct tgacagcggg ctaccgaaca cagcgtcgcg tccggacact ccgtcgtgtc
    15301 agtagtccca tgtggccact ccgtctcgcc gcgctcggct catccttcag ccgttgccca
    15361 tatgtcagct gaggctgtac tgttccttcc gtgctgacat gtgagactca gggtgccgcg
    15421 ctcgccaggc tgggccgtgc cctcgccgac ccgaaccggt gccggatcct ggtcgccctt
    15481 ctcgacgggg tgaactatcc gggccaactg gccgaccagc tcggtttgag ccgctccaac
    15541 gtgtccaatc acctggcttg cctccgaggc tgcgggctgg tcgtggccac ctatgaaggc
    15601 aggcaggtcc gctacgcgct ggcggacgcg catctggccc gcgcactgcg ggaactggtt
    15661 caggtcgtgc tcgcggtcga caccaccgag gcctgtgtgg acgatgccga ggtgctccga
    15721 tgagcatgga aagcacttcc tgtgtggacg gctgctgcac cgcgaagtcc acgctggacc
    15781 cggatcgccg ggccgtactg tcgcgccggg tccggctcct ggtcgccgcg acgatcacct
    15841 acaacgtcat cgaggcggtc gtcgcgatct ccgcgggcac catcgcctcc tcgaccgcac
    15901 tgatcggctt cggcctggac tcggtcatcg aagtcgcgtc cgccacggcc gtcgcctggc
    15961 agttcgccgg taaagatccc gaagcccgcg agcgcaccgc actcaaggtc atcgcggtgt
    16021 cgttcttcgc gctggccgcc tatgtcaccg tcgaatcgat acgcaccctg ttcggcgccg
    16081 atcccgccgg acattccacc gtcggcatcg tgctggcggc ggtctcgctg ctcgtgatgc
    16141 ccttcctctc ccacgcccag cgtcgcgccg gccgggaact cggctccgcg agcgcggtcg
    16201 ccgactcgaa gcagaccttg ctctgcacct atctttccgg cgtgctgctg gtcgggttgc
    16261 tgctcaacag tctcctcggc tggtactggg cggatccgct ggtcgccctc gtcatcgccg
    16321 ccgtcgcgat caaggaaggc cgcgaggcct ggcgcggcga gcactgctgc tgaaaggagc
    16381 gtcatgaccc gcaccgtgcg ctggaatcgt tactgggacg gtaaatcccg gaactacgac
    16441 cgggagatgc agtttctcga ccggaagctg ttcggcgatt cgcgggcgtg ggcgtgcggc
    16501 caggccgacg gcgatgtcct cgaagtcgcc gtcgggaccg gcctgaacct gccgctctat
    16561 cccgaaggtg tcatgctcac cggcatcgat ctcagtgacg gcatgctcgc catcgcccgc
    16621 gcccgcgccg aacgtctcgg tcatccggtg acactgcggc gggccgacgc ccacgaccta
    16681 cccttcgagg ccggttcgtt cgacaccgtg gtctgcaccc tcgggctctg cgccatcccc
    16741 gacgacggca aggcgttgcg ggaaatgacg cgggtcctcc ggcccggcgg gcggctcgtt
    16801 cttctcgacc acgtcgccag ttcgtcgcgc gttgtccgag gcctgcaatg gctcgccgag
    16861 aaggtcaccg tgccgatggc gggtgaacac tttctccggc gcccgctcga caagatcggc
    16921 ggcctcggcc tgaccgtgga acaccgggag cggttcaaac tcggtctggt ggaacggctc
    16981 gtcgcccgga agtgaacagg ggtcaggcgg cttcccaggc ggcctcgatc atccggaaga
    17041 tctcgtccac cgcggcctca gggtcggccg cctcacggcc cagcgaatag gcgtcgatca
    17101 cgaatctcgc gatcgtgcgg caggccgtcg cggactgcga cagatcggga tcggcggcga
    17161 tggccgccgc cagcgactcc gcgtgacgca gccgcatcga gtcctcgtag tcccgcagcg
    17221 cgggcgattc gtcgatcatg cggaagatcg gcgccgcgcc gtccgccgtg cagtgccgca
    17281 ccatcgcgtg gacctgccgc cgcagcgcgg ggatgagcgg ctcgtccgga gccctttcgg
    17341 tgaccgctcg cgtgagacct tgctcgaagt ccgcgtcctg ctcgaacacc aaagcctctt
    17401 tcgaggcgaa gtgggagaag agcgtggtca cggcgacgtc ggcctccgcg gctacctcac
    17461 ggatgcccac ctcgtcgtac ccgcgttcca ggaagagccg cagagcggtc tcggcgatct
    17521 tctggcgggt cgcggccttc ttgcgctcgc gacgcccggt cggcgcggtc atgaggcgac
    17581 gctatcagat ccaaaacaac aacagttcca aaacactaac ggttagtgct acggtcgatc
    17641 tcatgaagaa agtgatcttt accgagttcg gcggtccgga agtcctgcag ctggtcgacg
    17701 ccgaggcccc tcacgcggga ccgggtcagg tgcgcatcgc ggtgcgggcg gcgggtgtga
    17761 acccggtcga ctggcggatc cgcgagggtc aggtcctggg ggctcatccg accgtgttgc
    17821 cgtccggggt gggcatcgac gccgccggga tcgtggacga ggtcggcgaa ggcgtcaccg
    17881 gtgtcgaggt cggcgactcc gtgttcggcg agggttcgag tacctacgcc gagttcgccg
    17941 tcctgccggc ctgggccagg atgcccgcga acctgtcgtt cgaagaggcc gcgggatacc
    18001 cctccgtggt cgagacggcg ctgcgcctca tccgcgaggt cgacgtgcgg cctggtcaga
    18061 cgctgctggt cagcggcgcg tccggcgggg tcggctcggc ggtcctgcag atcgcccgcg
    18121 aacgcggcat caccgtgatc ggcacggcgg gcgccgcgaa ccaggactac ctgcgcggcc
    18181 tgggtgccgt cgccacgacg tacggcgagg gctgggtgga gcgggtgcgg cgactcggcc
    18241 gggtcgacgc ggccctcgat ttggcgggtt caggcgtgat cggcgaattg gtcgagctga
    18301 ccggggatcc ggggaaggtg ctctccatcg ccgatctcgg cgcccccgag ttcggcgtcc
    18361 ggttctccgg cgtcgccggg agtgtgccgg acgcgctggc cgaggccgtc gacctcatct
    18421 cgcgcggcaa gctgcatatc ccggtggaga agtcctactc gctcaccgac gccgccgcgg
    18481 cgcacgccga cagccacgcc gggcacgccc gcggacggcg ggtcatcgtc gtctgagccg
    18541 gctcaggctg tggtcgcggg aaggatcacg actccgtcgt catcggagta aagagtgtcg
    18601 ccgggagtga aggtcactcc cccgaaaccg accgggacgt cgacagcgcc gacgcccgcc
    18661 ttggaactct tgcgcgggtt ggtgccgagc gccttcacgc cgagcgggag tccggcgagc
    18721 tcggcgctgt cgcgtaccgc gccgtggacg accacgcccg cccagccgtt gtcgacggcg
    18781 gatttggcga tcatgtcgcc ggtgagcgcg ctatgcaggg agccaccgcc gtcgaccacc
    18841 aggacaccgc cttcgccggg tgtggccagc agcttcttga ccaggccgtt gtcctcgtga
    18901 caggagaccg tccggatcgg acccgcgaac ttccggtgtc cgccgaactg gcggaactgg
    18961 gtgtcgcaga cgtgcagcct gtcgccgtgt tcgtccacga ggtcggcggt ggtgaaggaa
    19021 tcgatcacgg cgcctgagtg taggtggcga tcagccagtt tcgcgcctcc tcgatgagat
    19081 ccgccacacg ccgggcgtcg gggatcgccc gcagctccag taccggcgcc gcccaggcgc
    19141 cgcggagttc gttgctccgg acccgtgagc ggccccaccg gctgccgtag gtgaccgtgc
    19201 cgacgcccgt ctcgtccacc ttgacctccg gcggatgctg caggtaccgg aaccagaccc
    19261 agcggaactc ggtaccggcc tgccagttcg cgacgaagat gatccgctga ttggtgacca
    19321 tgtacgtgag gacgttttcc ctcgatcgcc ggtcgctcag gcgctggtgg aaaaggatga
    19381 agaaggccgc gaacaggccg atgaacgggg gcaatcccga gtgttccacc caaacgaaga
    19441 acaggaagac gaacgggacg gccagcgcga ccatctggat gtgctccgga aaccactttc
    19501 gcggccgctg tggcgctccg gtccacagca cttcttcgcc ttcttgcaac ggatacaact
    19561 gcatcggcct ctcccccggt gtcatcagga gcacgccggc cctgtccgct acgttgcctt
    19621 gatcgggatc attgtttcca gcacgtgagc gaggatggcc gccgggtccg ccgcaggggc
    19681 gacgctctgc cgcagggcga gcccgatccc cagagcgccc agcatgacga cggcctgatc
    19741 cagcggcagc gcgggttcga gacgcaggcg ccgggtgtgt tcggtgagca gggccaccac
    19801 ctcgtcgtcg tgacgacgct ggatggcggc gaccagcgtg gcggtttccg gttgctgcgc
    19861 ggtcgcggcg agcacttccg cggccgccgc gctccacttc gccgcgtcct tgtccgccac
    19921 gtcgacggga ttcagcgccg cgatcacctc ttcacgggtg gcggcacggg cgagagcttc
    19981 ccgcaggccc tggagatgac cgtccgcgtc ggccctgatg atcgcgagcc acaacccttc
    20041 cttaccaccg aagtgcttgt aaacggcgcc gcgggtgtac ccggcgtcgg ccgcgatctc
    20101 ctcgaccgtc gccgccagga aaccacgccg caggaagacc tgacgcccgg cgcccagcag
    20161 gtgctcgtgg gtgcgccgct gctgctcggc ccgtgtcagc ctggtcatcg cccacccatt
    20221 cagtaacagt acgtttctag aaacacgacg ttactgtatc gtcggatgca tggagctcct
    20281 ggcacccgtg gcggcgtttc ttagccttcc cctcttcttg gccgggttcg cgtggtacgc
    20341 cgtgcgagcc cgtagccgcg gcgtgagtca gtccttgctg gcgccgatcg aggagatctg
    20401 ggatccgatc gcgcacaaga ccaacatcga gatccagatc gaggccgaac ggagcccgga
    20461 gaccccctcg cccggcgatc cgcccgagcc gatgtggcgg ccgtgacggt gcgcgagttc
    20521 agtatccgac ggtgaaatgc cggtctccgc cgggattctc gagttcgtcc acgatggcga
    20581 cggcgagatc ctccgccgag atccgggacg atccgtcctc cgcggtgagg atggtcgtcg
    20641 tcccccgccg gtaggtgccg gtccggattc cgggctcaag catggcgggc gggctgaggt
    20701 acacccagtc gccgtcgtgc gcctcgcaga cttggagctg tgtcgtgctg gccgaggcga
    20761 tcgtccgcca cgacagcggg acgaacaccg ggtcgtcgat gaccagcccc ccggacggcg
    20821 agcgcaacgg tccggcgcca ccgacgacca ggacacgggt gcccgccgcg gcgtcaagca
    20881 gggctttggc ggtcgcggcg acggtgtcct ccgcgcccgg agccggtctt gtcgcgccca
    20941 cgacggcgtc gactcccccg aagacttcgc tcatgcggcc gacatcggtg atgtcgccgc
    21001 ggacgatctc gacgtccgga tgccgcgagt ccggcggtgt gcggcggaag acagcggtga
    21061 cgtggtgccc gcgggagatg gcttcggtga cgacacggga gccggtcatg cccgctgctc
    21121 cgacgacggc gatcttcatc ggacgc
//
