LOCUS       NZ_KB913032            22553 bp    DNA     linear   CON 28-APR-2024
DEFINITION  Amycolatopsis alba DSM 44262 scaffold1, whole genome shotgun
            sequence.
ACCESSION   NZ_KB913032
VERSION     NZ_KB913032.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Amycolatopsis alba DSM 44262
  ORGANISM  Amycolatopsis alba DSM 44262
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9811274)
  AUTHORS   Klenk,H.-P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Amycolatopsis alba DSM 44262
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: India
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 44262
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v. 4.24
            finishing_strategy                :: Missing
            environment                       :: Soil
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi10729
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2011
            Isolation Site                    :: Soil
            Cell Shape                        :: Filament-shaped
            Motility                          :: Nonmotile
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram+
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v.
            4.24
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina GAii
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000384215.1-RS_2024_04_28
            Annotation Date                   :: 04/28/2024 01:36:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,988
            CDSs (total)                      :: 8,922
            Genes (coding)                    :: 8,855
            CDSs (with protein)               :: 8,855
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 24 of 67
            Pseudo Genes (incomplete)         :: 49 of 67
            Pseudo Genes (internal stop)      :: 4 of 67
            Pseudo Genes (multiple problems)  :: 10 of 67
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4156445
            Orig. end                         :: 4178998
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB913032.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 404842
            Source DNA and Organism available from Hans-Peter  Klenk
            (hpk@dsmz.de)
            Source DNA available from Hans-Peter  Klenk (hpk@dsmz.de)
            Organism available from Hans-Peter  Klenk (hpk@dsmz.de)
            Contacts: Hans-Peter  Klenk (hpk@dsmz.de)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22553
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="15"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22553
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22553
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12553](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12553
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(148..157)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.1"
                     /tool="antismash"
     gene            157..360
                     /locus_tag="AMYAL_RS0119770"
     CDS             157..360
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441988.1"
                     /locus_tag="AMYAL_RS0119770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cold-shock protein"
                     /protein_id="WP_005149851.1"
                     /transl_table=11
                     /translation="MAQGSVKWFNGEKGFGFIAQDDGGPDVFVHYSEIQGSGFKSLDEG
                     QRVEFEIGQGQKGPQAQRVVAI"
     misc_feature    complement(440..455)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            580..1809
                     /locus_tag="AMYAL_RS0119775"
     CDS             580..1809
                     /GO_function="GO:0004806 - triglyceride lipase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016042 - lipid catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003091799.1"
                     /locus_tag="AMYAL_RS0119775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lipase family protein"
                     /protein_id="WP_026467256.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 4.2e-05, bitscore:
                     22.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFSARPALLSSAVTAGLVAALLSFGAAPAGADPGFYEPPSPLPS
                     GADGDVLKTLPSRFNGAKSTRVMYLSRDTANRAIPVTGTVLVPDKAWTGPGQRPIVAYA
                     PFTAGMGDQCAPSKALAGEGGDLVSSFQSSFVSSLLDKGFAVAQTDYQGLGTPGEHTYV
                     VREAEAHVVLDVLRAAQRLPGAGLSAASPVGIAGYSEGGGASASAVELAPAYAPELDLK
                     GAYVGAAPADKAVLAKSLDGGMYVGFLGYSLIGLDAAYPEAGILDLANDAGKQLFAEAR
                     TTCTLDGVLKYMYRSTGQLTKDGRPVSAYLEQEPFRGIVAANRVGTLKPAAPVLVEHVP
                     NDDVIPSGIGKQLGKDWCAKGANVRFQDIPSLSPIFTHVLGINGAQGDAANWLAERFAG
                     KPAPGNCGQF"
     gene            1885..2529
                     /locus_tag="AMYAL_RS0119780"
     CDS             1885..2529
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030754.1"
                     /locus_tag="AMYAL_RS0119780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_020633035.1"
                     /transl_table=11
                     /translation="MRPDAVSRSALEPEQVGRKVRLREVGLRDRRVLMGFDRDMAREAS
                     TLIGGGHRHWASHRSGSAGDDIHFGIETVRGRMLVGSVCTIGADPVTGRFGYGIGIAPR
                     HQRCGYAADAITVLLAHMFEQRGFRKCEVTVYGGNLASLSLHAGLGFREEGRLRDTEVV
                     RGEIKYLVRMGITVEEFAARPAEAPADLGGRGQHRRPRRGKHWRAPAAVSG"
     gene            complement(2519..3166)
                     /locus_tag="AMYAL_RS0119785"
     CDS             complement(2519..3166)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163340.1"
                     /locus_tag="AMYAL_RS0119785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_020633036.1"
                     /transl_table=11
                     /translation="MTIRVVIADDQALVRTGLRMILENADDIDVVGEAGDGAEAVGLVA
                     DLDPDVVLMDIRMPEMDGVEATVAIAAAHRARVLVLTTFDLDEYVYAALQAGASGFLLK
                     DALAPDLLSGVRVVAAGEATLAPTVTRRLLDRVVTGLPASASDERLALLTGRENEVLRQ
                     LARGLSNAEIAEKLYLSPGTVKTHVGRILTKLGLRDRVQAVVFAYESGMLSR"
     gene            complement(3163..4365)
                     /locus_tag="AMYAL_RS0119790"
     CDS             complement(3163..4365)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163341.1"
                     /locus_tag="AMYAL_RS0119790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_020633037.1"
                     /transl_table=11
                     /translation="MLVNLRSHPRAVDVGLTVLIGLSTVVSADDPEGLEWWLTSLAGLA
                     SLLVRHRNPLITFSAGMAVSLLHLAMGNDLRPVDVVPLIGLFSVAAWGSRRLSVTLLAA
                     GLLVAGAWTFHASQANSREPGPPPPRIIIIDPLAPFDVDTDHRQVQDWGGFPGIGLSLA
                     VAWLAGLNTRQRRIRLSVLEQRAADLERERDTQAALAVAAERGRISRELHDVVAHSLSV
                     MVLQAQGAQAEMDRRPERAREAMDAVVGTGRTALSEIRRLLGALGQDEPDWEPRPGAER
                     LPRLVADVRSAGTPVEFLVEGEPRPLPSTVDLAAYRIVQEALTNVLKHAGPDASVTIVM
                     RYGPVALEIEVTDDGVAAEPPSCTGHGLEGMRERVNVLGGTFEAGSRPDRGFAVRATLP
                     S"
     misc_feature    4503..4518
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     gene            4504..5592
                     /locus_tag="AMYAL_RS0119795"
     CDS             4504..5592
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030757.1"
                     /locus_tag="AMYAL_RS0119795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetylhydrolase"
                     /protein_id="WP_026467257.1"
                     /transl_table=11
                     /translation="MRRLLVAVAVIAGLVSLASPASAVPRLTLPPPTGSYPVGSTDLHL
                     VDRARKDPWVPTGPRELMVSMFYPALLPVGPKRPYLTLAEAKMFLAGSGLPDIDPARVA
                     GIRTSARVDAPPLPGKRALVVLSPGFNKPRTTLTGLAEELASKGFVVAVVGHNYEAFAT
                     GFPDGHVTDCVACGSDSKLLPPVRAADVSFLLDTLTSASSPWSRLIDRTRIGMAGHSIG
                     GYSTPTAMVADQRIRAGADLDGRLWSPIPASGIDRPFLLLGRESEYTPAGPDTTWAANW
                     PNLTGWKRWISVAAAAHPSFTDVGVLGEQLGLREPGVLDGARGMQLTRAYVSAFFDKHL
                     YGGRQPLLDGPVAGNPEIKFWN"
     misc_feature    4514..4534
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.13"
                     /tool="antismash"
     gene            complement(5589..6545)
                     /locus_tag="AMYAL_RS0119800"
     CDS             complement(5589..6545)
                     /NRPS_PKS="Domain: PKS_KR (31-113). E-value: 1.1e-06.
                     Score: 20.7. Matches aSDomain:
                     nrpspksdomains_AMYAL_RS0119800_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030758.1"
                     /locus_tag="AMYAL_RS0119800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_020633039.1"
                     /transl_table=11
                     /translation="MITSQHKIGSGFDARSTAAEVLDGIDLSGKLALVTGGYSGLGLET
                     TRALANAGAHVVVPARRPADAEAALAGISGTEVGELDLADLTSVEAFAHRFLDTGRSID
                     LLIAGAGIMAAPERRVGRGWESHFAICHLGHHALVSRLWPALTASGGARVVTVASSGHH
                     SSPMRWHDVHFERGYDRWLAYGQAKTANVLFAVHLDKLGAGHGIRAFSLHPGAILTPLQ
                     RHLRPEEMVERGWIDEHGNQADPDFKSPEQGAATQVWAATSPSLDGLGGLYCEDCDVAE
                     IAEEEGEWVGVRPYAIDAGEAARLWKLSDDLTGVSLG"
     aSDomain        complement(6207..6452)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AMYAL_RS0119800_PKS_KR.1"
                     /evalue="1.10E-06"
                     /label="AMYAL_RS0119800_PKS_KR.1"
                     /locus_tag="AMYAL_RS0119800"
                     /protein_end="113"
                     /protein_start="31"
                     /score="20.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="ALVTGGYSGLGLETTRALANAGAHVVVPARRPADAEAALAGISGT
                     EVGELDLADLTSVEAFAHRFLDTGRSIDLLIAGAGIM"
     CDS_motif       complement(6372..6449)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AMYAL_RS0119800_0001"
                     /evalue="5.90E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="AMYAL_RS0119800"
                     /protein_end="58"
                     /protein_start="32"
                     /score="22.1"
                     /tool="antismash"
                     /translation="LVTGGYSGLGLETTRALANAGAHVVV"
     gene            6601..6993
                     /locus_tag="AMYAL_RS0119805"
     CDS             6601..6993
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633040.1"
                     /locus_tag="AMYAL_RS0119805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_020633040.1"
                     /transl_table=11
                     /translation="MTELAIGQVTDRTGLSVHALRFYEKEGLLAAPVKRDTNGRRVYTE
                     YDVEWLVNCTKFRASGMPLATIREFAELVRQGPGNEEKRLGLLRAHQDTVRDRIAELAD
                     CLELISRKVEVYEEHVARGTADALWR"
     gene            7105..8091
                     /locus_tag="AMYAL_RS0119810"
     CDS             7105..8091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633041.1"
                     /locus_tag="AMYAL_RS0119810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MCE family protein"
                     /protein_id="WP_020633041.1"
                     /transl_table=11
                     /translation="MRSFGAVDPVKMALAGLTTMALGMAAALNADALPVIGGGTTYSAE
                     FSDAGGLRADNDVRIAGVKVGKVSEIDLEGDRVLVSFRVKDAWLGDATSASIRIKNVLG
                     QKYLALDPRGEAILDPGDAIPLRRTTAPYDVLEAFRDLSKTVDAIDVDQLAKSFDAISA
                     TFADTPADVRAALDGVSKLSGTIASRDRQLRTLVANTRQVSQTLVDRDTEVQRLIQDGN
                     ALLRAISTRQQAIKDLLDGSKRLATALDGIIVDNDGQLGPVLEQLDRLTSMLQRNQDSL
                     AKGIAAFAPAIRVLTNVAGNGHWIDGYLCGLILPSFGPLNEKGCFEK"
     gene            complement(8794..9216)
                     /locus_tag="AMYAL_RS0119815"
     CDS             complement(8794..9216)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163353.1"
                     /locus_tag="AMYAL_RS0119815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020633042.1"
                     /transl_table=11
                     /translation="MPEETEEKTVDTHPDKTSGPGRILVAVYAIFALAATSRAAVQIST
                     KYQEAPLAYILSAFAAVVYLLATVALARRGAGWWRIALAACGIELLGVLTVGTFSLFDR
                     EAFPHATVWSVYGQGYLFIPLVLPVIGLFWLRRTKP"
     gene            complement(9209..9574)
                     /locus_tag="AMYAL_RS0119820"
     CDS             complement(9209..9574)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633043.1"
                     /locus_tag="AMYAL_RS0119820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020633043.1"
                     /transl_table=11
                     /translation="MITGFAVTVAICASLVAVWSFVQSVRKKLPDNALLTGLAVVELLL
                     VAQLVIGVVLLLGGDRPGSMATYLAYLIGSLVVLPLGTFWALAERTRSSTAILGIACLA
                     IPVMVLRLHEVWAGASA"
     misc_feature    complement(9675..9690)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(9814..9829)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            10001..12553
                     /gene="lanKC"
                     /locus_tag="AMYAL_RS0119825"
     CDS             10001..12553
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163355.1"
                     /locus_tag="AMYAL_RS0119825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_020633044.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1348.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 5e-08, bitscore: 31.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.3e-08, bitscore:
                     31.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAYCFADPLFFDEQQETGNAADDFASLLPAPESGWRTGVR
                     GVWRMLHPVARNLPLQGWKIHVSAGLGNAERVLAKVHEHCLEHTLSYKHLRSRSTLLAR
                     NSKYAPRDGSGKLLTLYPADNNELERVLVELSVKLDGEPGAYILSDLRYGAGPLYVRYG
                     GFAEQWVELDGKRVLAVRKPDGTLVPDKREPTFSVPDWVTIPEFLAPHLAARKSGGVDQ
                     FPYRVKSSLHFSNGGGVYLADRNADDERVVLKEARPFAGLDRDEIDAVERLRREHEVLE
                     RLKGVDGIPAAFERFTVWEHHFLAMEYMPGISLGNWLARNYPLTRRDTTEADIAAYTER
                     ALALVGRVEKMVGDVHGRGIVFGDLHSLNILVDGDEKDDTAVSLIDFEMASDVESGDRP
                     ALGAPGFRAPRDRNGFEVDEYALAVLKLWIFLPLTTLLELAPAKLRGLADFVQKRFAVP
                     EGYADSIVAELAPRNIPPLTSATELDQGKPDWALVRKQITEAILASATPERTDRLFPGD
                     IEQFRVGGACFGYGAAGVLHTLNTVGGERHPGHERWLLDSIRRDPPGRPGFYDGSYGIA
                     YVLEELGYRDEATKLLAASATLVEQTTDHGLEGGLSGIGLTQLHFAVARKDNEFGRQAL
                     TTAVRLAEALEIADPPGDFARAGLLNGWSGPALLFVRLFERTREEGWLSFADQALERDI
                     EECVESDDGSLQVRDGETRTLPYVGVGSAGILMVAEELAKYRPDAKALKSLPGLREACR
                     GEFVIHPGLLFGRGGLMTALAMGAEPDRRARDAIDLHLSRLAWYAVPYKGGLAFPGNQL
                     LRLSMDVVTGGAGVLLALAATLDGKAALPFLSSRTAVH"
     misc_feature    10349..10351
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12570..12583
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.53"
                     /tool="antismash"
     gene            12593..12739
                     /locus_tag="AMYAL_RS49265"
     CDS             12593..12739
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="AMYAL_RS49265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_093976479.1"
                     /transl_table=11
                     /translation="MELVLDLQALEAPEVLDGGHGGGGHGGGSNLSLLASCANSTISLL
                     TCH"
     CDS_motif       12593..12655
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELVLDLQALEAPEVLDGGHG"
                     /locus_tag="AMYAL_RS49265_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12656..12739
                     /prepeptide="core"
                     /locus_tag="AMYAL_RS49265_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="8.50"
                     /molecular_weight="2401.6"
                     /monoisotopic_mass="2400.2"
                     /core_sequence="GGGHGGGSNLSLLASCANSTISLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELVLDLQALEAPEVLDGGHG"
                     /leader_location="[12592:12655](+)"
                     /alternative_weights="2419.7"
                     /alternative_weights="2437.7"
                     /alternative_weights="2455.7"
                     /alternative_weights="2473.7"
                     /alternative_weights="2491.7"
     gene            12852..14519
                     /locus_tag="AMYAL_RS0119835"
     CDS             12852..14519
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633046.1"
                     /locus_tag="AMYAL_RS0119835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_020633046.1"
                     /transl_table=11
                     /translation="MAGSADRLLVEVTALDRPRLVALVLSALAGTASGLLLPGALAAAV
                     DAVVAGRPSFPEVSWLLSLGIVEILVGLIGGILSARMTSSATAWLRRRLADRHLALGTR
                     STFADGDAISRLTGDCTGAGLVASVVVQLGSTTLISGGSVVLLALMDWRLALVFLGSIP
                     FGLMLARTHLKNTADDVLTYQEVSGELAARMVDAVAGLRTIAASGTADREAERVLRPLP
                     KLSLAGRGMWRTQARMVWRSGLLLPAAELAVLAAAGFGVLEGRLTVGQVLAALGYVALG
                     MGLVTQIPLLTTLSRARSCARRINEVLDSPVPEPGDLSIVPGRGTLELREVTVEGALRD
                     VDLLVRGGRFTAVVGRSGSGKSALVNVLGGLLTPDEGTATLDGRPLERLRPYELRAVVG
                     FAFERPALHGATIGDAVGYGSWAGEAAVRGACRSAQVDDLIVRLPDGYRTPLSETPLSG
                     GEAQRIGLARAIAHAPRVLILDDATASLDTVTEAAVEEAIERTLPGRTRVVVTHRAATA
                     ARADMVVWMEDGRVRAVGPHGQLWRNPVYQAVFTEGAQ"
     gene            14516..16252
                     /locus_tag="AMYAL_RS0119840"
     CDS             14516..16252
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="AMYAL_RS0119840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_020633047.1"
                     /transl_table=11
                     /translation="MSVWGLYRSALAGQWRGGLVLLACSVLESAPAFLSGRLVELAVDE
                     GFAAGRPGTGLRWLAVFGLVAVLGAFGSRLVWHQLGKVVEPLRDALVTAVVRGVLHDPA
                     PPRNQPDASGVARITQHVEVVRDATAGLLVQARGMIVTTVAALAGLFTVAGSLALIVAI
                     PVVVAVVVFACLLPSLARRQRALALADERTAEVAGATLSGMRDIVACGAEPLAALDLYD
                     AIDTQAKAAVRVARSGAARAVVIAAGGFVPLLLALLVAPGLVKDGVLTAGAALGALVYL
                     ATTMQPALRGLGATASTVVLRLIVALRRLAETAQAEPEADGTAEPDGTAIYVRDLTFSW
                     GAAAEPVVRGLDLHLRPGERLAVVGPSGIGKSTLAGLLTGMLEPQAGRVLLGGVPVREI
                     PAALRHRLVALIPQEAYVFAGSVRDNVGLFAQTAMDGELLAAVTAVGAEPLVTRLGGLD
                     GEIGHGTLSAGEAQLIALARVYASDADVIVLDEATSHLDPPAEARAERAFAERGGVLVV
                     IAHRLTSALRADRVLVMDGKETALGTHLELMDRSTRYAQLMHAWSPRLPQPSAQFFQRA
                     PE"
     gene            complement(16208..16627)
                     /locus_tag="AMYAL_RS0119845"
     CDS             complement(16208..16627)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633048.1"
                     /locus_tag="AMYAL_RS0119845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioesterase family protein"
                     /protein_id="WP_020633048.1"
                     /sec_met_domain="4HBT_2 (E-value: 8.2e-16, bitscore: 57.6,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNAEYPHWQTVPLRWKDNDVYGHVNNVVHYSVMDTVINTWLIER
                     GGLDIETGGVIGLCVESQCKYHASVSFPGELEVGLRVGHLGRSSVRYEVGMYSKETVIA
                     EGRFVHVFVDRESRRPVPVEGLLRGALEELRAGLG"
     gene            complement(16621..17853)
                     /locus_tag="AMYAL_RS0119850"
     CDS             complement(16621..17853)
                     /EC_number="1.1.99.24"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0047988 - hydroxyacid-oxoacid
                     transhydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642937.1"
                     /locus_tag="AMYAL_RS0119850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxyacid-oxoacid transhydrogenase"
                     /protein_id="WP_039795606.1"
                     /sec_met_domain="Fe-ADH (E-value: 2.3e-103, bitscore:
                     344.8, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYGTGSSDEIGYDLTQYGARRVLVLTDADVAATGWPQRIAEGIE
                     TYGIEAVVFDGVHVEPTDVSMRKAVDFARGQGEWDAFVAVGGGSAIDTAKAVNLLTSND
                     GDLLDYVNAPVGGGRAPSAPLKPLVAVPTTTGTGSESTTVCVLDVLSLRVKSGISHLRL
                     RPSLAVVDPRLTVSQPPEVTAASGMDILCHAAESYTAKPYTEFDRKRPEDRVPYCGSNP
                     LADMFAEQSLRLLSWALPAAVRDGSDLKAREAMALAATFAGLGFGNAGVHIPHANAYPI
                     AGQVRDFHPSGYPGEEAMVPHGMAVSLTAPAAFRFTFDAAPDRHERVARLLAPDYEWPG
                     DLRDHLPAVLRQIMREIGIPNGIGAVGYAESDVDSLVSGTVKQQRLLATAPREASEEDL
                     AGILRDSVTLW"
     misc_feature    complement(17872..17883)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.05"
                     /tool="antismash"
     gene            18024..19685
                     /locus_tag="AMYAL_RS0119855"
     CDS             18024..19685
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071745.1"
                     /locus_tag="AMYAL_RS0119855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_280632825.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.6e-38, bitscore:
                     128.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.9e-34, bitscore:
                     115.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYQPGASVAQTAVRILTEAQIHRVYAVAGESFLDLLDALQRERS
                     ITFVSARHDSGAAFMAEAEGKLTEHPAVLLAGRGPNAANLAIGVSTAYQDESPMVVLLE
                     NPPSSPGPTSELPTADLTAMFEPIVKWTGRAESPDEVPGLLVEALTRCREGRPGPTVVA
                     VPADFWGVPFDSAKPVAAVKAPATGALGRTAEAVAQLVDEARYPVVIVGGRARAAREEL
                     IAVADELALPVYNAFRRQDAFPENHARYAGHLGIGIPARQLDALERADLVLALGTQLDE
                     VTTQCFRYPTPSQTLVLVGTGIEPARRGGLTFRVDSEVEPFLRELRDVASPRQRRASAA
                     NAAVHTFMTPPDTSGATRVHPADVIRAVRKLAPEDAIVTSDAGNFAQFMHRYWCFTAPR
                     SQLGPSNAAMGYAVPAAVAAKLAEPRRTVIAMVGDGGALMTGQEIETAVRYRVPVTVLV
                     FQNGLHGPLAVHQARKHGRLSGVTVPVTDFASWARGLGAAGYTVDDREQLEPIIASALV
                     RQRPCVIDIRTDPDVVTPDIRLTSLLGAARPQQGQQ"
     misc_feature    19892..19907
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.91"
                     /tool="antismash"
     gene            19921..20091
                     /locus_tag="AMYAL_RS49900"
     CDS             19921..20091
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163371.1"
                     /locus_tag="AMYAL_RS49900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020633051.1"
                     /transl_table=11
                     /translation="MADETKPQDRSVSGVVPVLFSADAETHDIAVVATNREALRRSPFG
                     AEVPLRAASGE"
     misc_feature    20255..20270
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            20325..20528
                     /locus_tag="AMYAL_RS0119865"
     CDS             20325..20528
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="AMYAL_RS0119865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cold-shock protein"
                     /protein_id="WP_005163378.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGAKGPQATSVTVI"
     gene            20711..21592
                     /locus_tag="AMYAL_RS0119870"
     CDS             20711..21592
                     /GO_function="GO:0003951 - NAD+ kinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006741 - NADP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163380.1"
                     /locus_tag="AMYAL_RS0119870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(+)/NADH kinase"
                     /protein_id="WP_020633052.1"
                     /transl_table=11
                     /translation="MGEAVAGIVANPASERDIQSLRSALRVAGVGRVMVWTEAGKIIGT
                     VRRMVDAGASVVICLGDDGLMRAAAAACGDVPLLMLPTGSTDTLPEPTVAGLAAGLLAT
                     HQVDADLVTNRATILEVVTKARREIALNDVSVCSESRWDPASLTELYCTFAVPDGIGLS
                     SIPGRLCPSPKSTVDGVAVSLGPVEETPYVVQAPIAPGEVRSVGVRGWSVLDPGVRVDL
                     AAGGGSIALDGQPHFVLRPGESAFVELKPDGPWCVDVRAVMAEATRTGLLLGRRPQGAF
                     PKYHLADAPFTG"
     gene            21671..21793
                     /locus_tag="AMYAL_RS50815"
     CDS             21671..21793
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AMYAL_RS50815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_279629241.1"
                     /transl_table=11
                     /translation="MGKMNVKGLLGLVVIGVVVLLGFLAYRLILVEMITRLSDH"
ORIGIN
        1 gaccatccgg ccgactcgcc aagggtgacg ttgacctggg gatttgtact aatttgggac
       61 ggcgacgtgt gttccggcgc gacacctgcg agaatgacaa gtgagatcgg ggcatcgaat
      121 gggctcagac tcgctatgaa gagcaggtaa aaaagtatgg ctcagggcag cgttaagtgg
      181 ttcaacggcg aaaagggctt cggcttcatc gctcaggacg acggcggacc ggacgttttc
      241 gtgcactact cggagatcca gggcagcggc ttcaagtccc tggacgaagg gcagcgcgtt
      301 gagttcgaga tcggccaagg tcagaagggc ccgcaggccc agcgcgtcgt cgccatctga
      361 cttttctcca cctcgaaggc ccccatcctc tccggatggg ggccttcggg cgtttgaggg
      421 gcgggtcacc cggcggcgtg tgacaaaaac gccgaaaccc gtgctcagcg agctgacaag
      481 gcccggaatc gctggttgac ggcctgcccg cctgcctcca ctgtgggctt ctctcgccgg
      541 tccggcgaga ggaacccgag ctcatcagtg gagttcagca tgcgcttttc cgcccggcct
      601 gccctgctgt ccagcgcggt gaccgccggt ctcgtcgccg ccctgctgtc cttcggggcc
      661 gcgcccgccg gcgccgatcc cggcttctac gagccgccgt caccgcttcc atccggtgcc
      721 gacggcgacg tgctcaagac gctgccgtcg cggttcaacg gcgccaagtc gaccagggtc
      781 atgtacctga gcagggatac cgcgaatcgc gccatcccgg tgactggaac ggttctggta
      841 cccgacaagg cgtggaccgg gccggggcag cggccgatcg tggcgtacgc gccgttcacc
      901 gccgggatgg gtgatcaatg cgcgccctcg aaggcgctgg cgggcgaagg cggcgacctg
      961 gtctcgtcgt tccagagctc cttcgtgagc tccctgctgg acaagggctt cgcggtcgcc
     1021 cagaccgact accagggact cgggacgccg ggcgagcaca cgtatgtggt gcgggaggcc
     1081 gaagcgcacg tggtgctcga cgtcctgcgg gcggcccagc gactgcccgg cgccggactt
     1141 tcggccgcgt cgcccgtggg catcgcgggc tactcggaag gcggcggcgc ctcggcctcg
     1201 gctgtcgagc tggcgcccgc gtacgctccc gagctcgatc tgaagggcgc ctacgtcgga
     1261 gcggctcccg cggacaaggc ggtcctcgcg aagagcctcg acggcgggat gtacgtcgga
     1321 ttcctgggct actcgctgat cggcctggac gcggcctatc cggaagccgg gatcctggac
     1381 ctggccaacg acgccggtaa acagctcttc gccgaggcgc gcaccacctg cacgctggac
     1441 ggcgtcctca agtacatgta ccggagcacc ggtcagctga ccaaggacgg gcggccggtc
     1501 tcggcctacc tggaacaaga acccttccgg gggatcgtcg cggccaaccg cgtcgggacg
     1561 ctcaagcccg cggcgccggt gctggtcgaa catgtgccca acgacgacgt catcccgtcg
     1621 ggtatcggca agcagctcgg caaggactgg tgcgccaagg gggcgaacgt gcggttccag
     1681 gacatcccgt cgctgagccc gatcttcacc cacgtcctgg gcatcaacgg cgcccagggt
     1741 gacgcggcga actggctggc cgagcggttc gccgggaagc ccgcgccggg gaactgcggc
     1801 cagttctaga cgacgggccc aggacgccgg gccgggcggc taccgatatc gtcaagggat
     1861 gcttgtgatc gttcgtgagc acccgtgcgg ccggacgcgg tgagccgctc cgccctcgag
     1921 ccggagcagg tcgggcggaa ggtgcggttg cgcgaggtcg gcctccggga ccggcgggtc
     1981 ttgatgggct tcgatcgtga catggcccgc gaggcgtcga cgctgatcgg cggcggtcac
     2041 cggcactggg cctcgcaccg ttcgggttcc gcgggcgacg acatccactt cggcatcgag
     2101 acggtccgcg gccggatgct ggtcgggtcg gtctgcacca tcggcgccga cccggtgacc
     2161 ggccggttcg gttacggcat cgggatcgcc cctcgccacc agcgctgcgg atacgccgcg
     2221 gacgccatca ccgttctcct ggcgcatatg ttcgagcaac gcggcttccg caaatgcgag
     2281 gtcaccgtgt acggcggcaa cctggcgtcg ctttcgctgc acgccggcct cggcttccgc
     2341 gaggaaggca ggctgcgcga caccgaagtg gtgcgcggcg agatcaagta cctggtacgg
     2401 atgggcatca cggtggagga gttcgccgca cgtcccgccg aagcccccgc cgacctcggc
     2461 ggacgcggcc agcaccggcg gccccgccgc ggcaagcact ggcgcgcgcc cgccgcggtc
     2521 agcggctgag catcccggac tcgtaggcga agacgacggc ctgcacgcgg tcgcggaggc
     2581 cgagtttcgt caggatgcgg ccgacgtggg tcttcaccgt ccccggcgac aggtacagct
     2641 tctcggcgat ctcggcgttg gacaggccgc gggccagctg ccgcagtacc tcgttttcgc
     2701 gcccggtgag cagggcgagc ctttcgtcgg aagccgaggc gggcaggccg gtgacgacgc
     2761 ggtcgagcag ccgccgggtg acggtgggcg ccagcgtggc ctcaccggcg gcgacgacgc
     2821 ggacgccgga gagcaggtcc ggcgccagcg cgtccttgag caggaagccg ctggcccccg
     2881 cctggagcgc ggcgtagacg tactcgtcca gatcgaaggt ggtcagcacc aggacacggg
     2941 cgcgatgggc cgcggcgatc gcgacggtgg cctcgacgcc gtccatctcg ggcatccgga
     3001 tgtccatgag cacgacgtcg ggatcgaggt ccgccaccag cccgacggcc tccgcgccgt
     3061 cgcctgcctc gccgacgacg tcgatgtcgt ccgcgttctc caggatcatc cgcaggccgg
     3121 tgcgcacgag cgcctggtcg tcggcgatca ccacccggat cgtcatgacg gcagggtcgc
     3181 gcggacggcg aaaccgcggt ccggccgcga tcccgcttcg aaggtgccgc ccagtacgtt
     3241 cactcgttcc cgcatccctt cgaggccgtg cccggtgcag gacggcggtt ccgccgcgac
     3301 gccgtcgtcg gtcacctcga tctccagtgc caccggcccg tatcgcatca cgatagtcac
     3361 cgacgcgtcc gggccggcgt gcttcagtac gttcgtcagc gcctcctgca cgatccggta
     3421 cgccgcgagg tccactgtgg acggaagcgg ccgcggttcc ccttcgacca ggaactcgac
     3481 cggcgtgccc gcggaccgga cgtcggcgac cagccgcggc agccgttccg caccgggccg
     3541 cggttcccag tccggctcgt cctggccgag cgccccgagc agccgccgga tctcgctcaa
     3601 cgcggtccgc ccggtgccga cgacggcgtc catcgcctca cgtgctcgct cgggccgccg
     3661 gtccatttcc gcctgggcgc cttgggcttg cagcaccatc acggaaaggg agtgcgcgac
     3721 gacgtcgtgc agttcgcggc tgatccggcc gcgttcggcg gccacggcca gcgcggcctg
     3781 ggtgtcgcgc tcgcgttcga gatcggcggc gcgctgctcc agcaccgaca ggcggatccg
     3841 gcgctgccgc gtgttcagcc cggccagcca cgccaccgcg agcgacagcc cgatgccggg
     3901 gaaaccgccc cagtcctgca cttgcctgtg gtcggtgtcg acgtcgaagg gcgccaacgg
     3961 gtcgatgatg atgatccgcg gcggtggcgg tcccggttcc cgcgaattcg cctgggaggc
     4021 atggaacgtc cacgctcccg cgacgagcag ccctgccgcc agcagcgtca cggagagccg
     4081 ccgcgatccc catgccgcga cggagaagag gccgatcaac ggcaccacgt cgaccgggcg
     4141 gagatcgttg cccatggcca ggtggaggag tgacacggcc atcccggccg aaaaggtgat
     4201 cagcggattg cgatggcgga ccagcaagga agccagaccc gccaaggaag tcagccacca
     4261 ctccagacct tccggatcat cggcagagac cacagtggac agtccgatga gtacggtcag
     4321 cccgacgtcg acggccctgg ggtggcttct gaggttgacc agcaccagcc gagcgtaatc
     4381 cccgatcgga cgcagcggat ccgcctcacg gcagacatcg ggatacgacc tgcggcagac
     4441 gcgcgaatac gccgcccggt cccaggctgg ggaacggaag atcctcgaca gaacggaacg
     4501 ctcatgagaa ggcttctcgt cgcagtggcg gtcatcgccg gcctggtgtc cctcgcgagc
     4561 ccggcttcgg ccgtcccgcg gctgacgttg ccgccgccga ccggctccta tcccgtcggt
     4621 tccaccgacc tgcacctggt cgaccgggcg cgcaaggacc cctgggtgcc gacggggcca
     4681 cgagagctga tggtgtcgat gttctacccg gcgctgctgc cggtcggccc gaaacggccg
     4741 tatctcacct tggccgaggc caagatgttc ctggccggat cgggcctgcc cgacatcgac
     4801 cccgcacggg tcgccgggat ccggaccagc gcacgggtcg acgccccgcc cttgccgggg
     4861 aagcgcgcgc tggtcgtcct gtcaccgggg ttcaacaagc cgcgcaccac actcaccggg
     4921 ctggcggaag aactggcgag caagggtttc gtcgtcgcgg tggtcggcca caactacgag
     4981 gctttcgcca ccggcttccc cgacgggcac gtcaccgact gcgtcgcgtg cgggtcggac
     5041 tcgaagctgc tcccgccggt gcgcgccgcg gacgtctcgt tccttctcga cacgctgacc
     5101 agtgcttcgt cgccgtggtc ccggctgatc gaccggacgc ggatcggcat ggccgggcat
     5161 tccatcggcg ggtacagcac gccgacggcg atggtcgccg accagcggat ccgggcgggc
     5221 gccgatctgg acggcaggct gtggtcgccg atccccgcgt ccgggatcga ccggccgttc
     5281 ctgttgctcg gccgcgaaag cgagtacacc ccggccggtc cggacacgac ctgggccgcc
     5341 aactggccga acctcaccgg ctggaaacgc tggatcagcg tcgccgcggc cgcgcatccg
     5401 tccttcaccg atgtcggcgt actcggtgaa cagctcggct tgagggaacc cggtgtgctc
     5461 gacggcgcgc gcggaatgca gctgaccagg gcgtatgtct cggcgttctt cgacaagcac
     5521 ctgtacggcg ggcgtcagcc gctgctggac gggccggtgg cgggcaaccc cgagatcaag
     5581 ttctggaact agcccaagga gacaccggtg aggtcgtcgg acagcttcca cagccgcgcg
     5641 gcctcaccgg cgtcgatcgc gtaggggcgc acgccgaccc actcgccttc ttcctcggcg
     5701 atctcggcga cgtcgcagtc ctcgcagtac agcccgccca gtccgtcgag cgacggtgac
     5761 gtcgccgccc agacctgggt ggccgcgccc tgctcaggcg acttgaaatc cgggtcggcc
     5821 tggttgccgt gctcgtcgat ccagccacgc tcgaccatct cctccggccg cagatgccgc
     5881 tgcaggggag tgaggatcgc gcccggatgc aggctgaacg cgcggatccc gtgtccggcg
     5941 ccgagcttgt ccaggtgcac tgcgaacagc acgttcgccg ttttggcctg gccgtaggcg
     6001 agccaccggt cgtaaccgcg ctcgaagtgg acgtcgtgcc agcgcatcgg cgaggaatgg
     6061 tggccggagg aggcgaccgt gacgacacgg gcaccgccgg acgccgtcag cgcgggccaa
     6121 agacggctca ccagggcgtg gtggccgagg tggcagatcg cgaaatgcga ctcccagccg
     6181 cggccgaccc gtcgttccgg cgcggccatg atcccggcgc cggcgatcag caggtcgatc
     6241 gagcgtcccg tgtcgaggaa ccggtgggcg aaggcctcga cgcttgtcag gtcggcgagg
     6301 tcgagctcgc cgacctcggt gccggagatc ccggcgaggg ccgcttccgc gtcggcggga
     6361 cggcgggcgg ggacgacgac gtgcgcgccg gcgttcgcca gcgcacgggt ggtttccagg
     6421 cccagccccg aatatccgcc ggtgacgagt gcgagcttgc ccgaaaggtc gatcccgtcc
     6481 aagacctccg cggcggtgct gcgcgcgtcg aagccggacc cgatcttgtg ctgtgaggtg
     6541 atcatgcggc gaacggtagg agctagaggg ctctctaggt caacagctag ggtcgtccgc
     6601 gtgacggaac tcgcgatcgg ccaggtcacc gaccggacgg gcctcagcgt gcacgccctt
     6661 cgcttctacg agaaggaagg gctgctcgcg gcaccggtga agcgggacac gaacggccgt
     6721 cgcgtgtaca ccgagtacga cgtcgaatgg ctggtgaact gcacgaagtt ccgggcgtcc
     6781 ggaatgccgc tcgccacgat ccgcgagttc gccgaactcg tccggcaggg gccgggcaac
     6841 gaggaaaagc ggctgggact gctacgggcg catcaggaca ccgtccgcga ccggatcgcc
     6901 gaactggccg actgcctgga gctgatcagc cggaaggtcg aggtctacga agaacatgtc
     6961 gcgcggggaa cggcggacgc gctctggcgc tgatcgaatg tccttaatgg acattcgaca
     7021 gtacccgatc ggtgcaacgt ttcgcctggc aagggacgcg aacggcccct agagtttgcc
     7081 gctcgtgacc tgcgaggtga ggcgatgcga tccttcggcg cggtggatcc ggtcaagatg
     7141 gcgctcgccg ggctcaccac gatggctctc gggatggcgg cggcgctcaa cgccgacgcc
     7201 ctgccggtga tcggcggcgg cacgacgtat tccgcggaat tctccgacgc gggcgggctt
     7261 cgcgcggaca acgacgtccg gatcgccggg gtgaaggtcg gcaaggtgtc cgagatcgac
     7321 ctcgaaggcg atcgcgtgct cgtctctttc cgggtgaagg acgcctggct cggcgacgcc
     7381 acgagcgcgt ccatccggat caagaacgtc ctggggcaga agtatctggc gctggacccg
     7441 cgcggcgaag cgatcctcga ccccggcgac gcgatcccgc tgcggcggac caccgcgcca
     7501 tacgatgtcc ttgaagcgtt tcgggatctg tcgaagaccg tcgacgccat cgatgtcgat
     7561 cagctcgcca agagtttcga cgcgatctcg gccaccttcg ccgatactcc cgccgatgtc
     7621 cgcgccgcgc tcgacggcgt ctcgaagctg tccggcacca tcgcctcacg cgaccggcaa
     7681 ctccggacgt tggtggcgaa cacgcgacag gtctcgcaga ccctcgtcga ccgcgacacc
     7741 gaggtccagc ggctgatcca ggacggcaac gccctgctgc gcgcgatctc cacccggcag
     7801 caggcgatca aggatctgct cgacggctcg aaacggctcg cgaccgccct cgacggcatc
     7861 atcgtcgaca acgacgggca actcgggccg gtgctcgaac aactcgaccg gctgacgtcg
     7921 atgctgcagc gcaaccagga ttcgctggcc aaggggatcg ccgcgttcgc cccggcgatc
     7981 cgggtgctca ccaacgtcgc gggcaacggg cactggatcg acggctacct gtgcgggctg
     8041 atcctgccct cgttcggccc gctcaacgaa aagggctgct tcgagaagtg agcggaaggg
     8101 gcgccggtgg ccgttcggtc gggctggtcg tgagtggcga ttcgggttag cgcggaccag
     8161 catttgccta cctacgcctg acctgcgcga gggtggcggt tccgcggctg tcggctcgac
     8221 ggtgaaggaa tcaggacgtt caacgtcctg attccttcac cgtcacgggg gtcgcccggt
     8281 ctcggatctt gatcaaggtc gtgccggtca tgtccggaaa cttcccccgt ggaccacacc
     8341 cgcatcagca caagctcgac ccggcaccga gacgaagcag gccgagcgtg gaggattccg
     8401 gacgttcaac gtcctgaatc ctccacactc gaccgccagt cgcaccagtg gggtaatacc
     8461 ggtccgttat tgaggggtaa gtcagatgtg tcctggcagg cggcgagtcc gtgaaggcat
     8521 ccttcgcgtc aagccctgcc gggttctctg gtgcccttgg ccgcacttcg ggatgtctca
     8581 aagggggcct tcaggacggt gaacgtccca cagggggcct tcgagacacg gcgcccgagt
     8641 cgcccgatcc caggtcgccc cgaatgtggc attggggaca ctcaacgtcc ccaatgccac
     8701 attcggcgca caccccaacg acacgacacg tttgccttac ccctcaatag agcccgaatc
     8761 gccactcacg accagccgca ccgacgccgt ccgtcagggc ttggtgcgcc gcaaccagaa
     8821 caacccgatc accggcagca ccagcgggat gaagagatag ccctgtccgt acaccgacca
     8881 cacggtggcg tgcgggaagg cctcgcggtc gaagaggctg aacgtgccga cggtcagcac
     8941 accgagcagt tcgatcccgc aggcggccag cgcgatccgc caccagcccg cgccgcggcg
     9001 ggccagcgcc acggtggcca gtagataaac cacggccgcg aacgcggaga gtatgtaggc
     9061 cagcggagct tcctggtact tggtgctgat ctgcacggcg gcgcgcgatg tcgccgccag
     9121 cgcgaagatc gcgtacaccg cgaccaggat ccgtccgggg ccggaggtct tgtccgggtg
     9181 ggtgtccacc gtcttctcct cggtttcttc aggcactggc gcccgcccag acctcgtgca
     9241 gccggagcac catcaccggg atggcgaggc aggcgatccc gaggatcgcg gtgctcgacc
     9301 gggtccgttc ggccaaggcc cagaacgtcc cgagcggcag cacgaccagg ctgccgatca
     9361 ggtaggcgag ataggtggcc atgctgcccg gacggtcgcc gccgagcagc agcacgacac
     9421 cgatcacgag ctgggccacc aggaggagtt cgacgacggc gaggccggtc agcaaggcgt
     9481 tgtcggggag ttttttacgc acggactgca cgaaactcca caccgcgacc agcgacgcgc
     9541 agatcgcgac ggtcaccgcg aagcctgtga tcacgcccgc ctccttacct gctccaccgg
     9601 cgacaacgta cctccgggcc gatcatcgcc gacgggcgac cggtgacggg cgtggcgggc
     9661 accacggaac gagcagtggt ccagacctcg ggtgaataga tcacgaagcg cgccgggttg
     9721 gcgctctgtc aattccccgg tgcctgattg tgatcggcgg cgctacctgg gattacgtcg
     9781 caggtacgtt cctgttacac accgaccggg tggttgaaaa cagagttgat ctcacgctgg
     9841 gtacccttac cattcggtag gtttcgaatt cacgtccctg aacagcccat ccgaaccccc
     9901 ggtatggcgg attggccgtt tgctttccgg cgggtggaat attctccatc gcgatggtgc
     9961 acatggccca tccgattggt gccgaaggag ggggcgctcg atggacgtcc ggtacgaagc
    10021 atattgcttc gccgatccgc tgttcttcga tgagcagcag gaaaccggga acgccgccga
    10081 cgatttcgcc tccctgttgc ccgctcccga gtcgggctgg cgcaccgggg tgcgcggagt
    10141 gtggcggatg ctgcaccctg ttgctcggaa ccttcccttg cagggctgga aaatccatgt
    10201 gtcggccggg ctgggcaacg ctgagcgagt gctcgcgaag gtgcacgagc attgtcttga
    10261 gcacacgctg tcctacaagc acctgcgttc gcggagcaca ctgctggcca gaaattccaa
    10321 atacgctccg cgtgacggga gtggcaagtt actgactctt tatccagctg acaacaacga
    10381 gctcgagcgc gttctcgtcg agctgtccgt gaagctcgac ggggagcccg gcgcctacat
    10441 tctcagtgat cttcgatacg gtgccggtcc gctctacgtc cgttatggcg gattcgcaga
    10501 gcaatgggtc gaactcgacg gaaaacgtgt cctcgcggtg cgcaaaccgg acggaacctt
    10561 ggttccggac aagcgcgagc cgaccttctc cgtacctgac tgggtgacga ttccggagtt
    10621 cctcgcgcct catctcgcgg ctcgcaagag cggcggagtg gatcagttcc cctatcgggt
    10681 gaaaagttca ctgcacttct ccaacggtgg cggcgtgtac ctcgccgacc ggaacgccga
    10741 cgacgagcgc gtggtcctga aggaggccag gccgttcgcc ggcctggacc gcgacgagat
    10801 cgacgccgtc gaacgcctcc gccgcgagca cgaggtgctg gagcggctga agggtgtcga
    10861 cggcatcccc gccgccttcg agcgcttcac cgtctgggag caccacttcc tggcgatgga
    10921 gtacatgccg ggcatctcgc tcggcaactg gctcgcccgc aactacccgc tcacccggcg
    10981 ggacaccacc gaggccgaca tcgccgcgta caccgaacgc gcgctggcgc tggtcgggcg
    11041 ggtggagaag atggtcggcg acgtgcacgg ccgcgggatc gtcttcggcg acctgcattc
    11101 gctgaacatc ctggtcgacg gggacgaaaa ggacgacacg gcggtctcgc tgatcgactt
    11161 cgagatggcg tccgacgtcg aaagcggcga ccggcccgcg ctcggcgcgc cagggttccg
    11221 cgccccccgc gaccggaacg ggttcgaggt cgacgagtac gcgctggccg tcctgaagct
    11281 gtggatcttc ctgccgctca ccacgctcct ggagctcgcc ccggcgaagc tgcgcgggct
    11341 cgcggacttc gtccagaagc gcttcgccgt cccggagggc tacgccgact cgatcgtcgc
    11401 ggagctcgcg ccccggaaca tcccgccgct gaccagcgcc accgagctgg accagggcaa
    11461 accggactgg gcgctggtgc gcaagcagat caccgaggcg atcctcgcca gcgcgacccc
    11521 cgagcgcacc gaccggctct tccccggcga catcgaacag ttccgtgtcg gcggggcgtg
    11581 cttcggctac ggcgcggcag gcgtcctcca caccctgaac acggtcggcg gcgagcgtca
    11641 ccccggccac gaacgctggc tgctggactc gatccgtcgc gatccgccgg gacgaccggg
    11701 gttctacgac ggctcgtacg ggatcgcgta cgtcctcgaa gagctcggct accgcgacga
    11761 ggccaccaaa ttgctggcgg cgtcggcgac cctggtcgag cagaccaccg accacggcct
    11821 ggaaggcggc ctgtccggga tcgggctcac gcagctgcac ttcgcggtgg cccgcaagga
    11881 caacgagttc ggcaggcagg cgctcacgac cgccgtccgg ctcgccgaag ccctcgagat
    11941 cgccgacccg cccggtgact tcgccagggc aggactgctc aacggctggt ccggtccggc
    12001 actgctgttc gtccggctgt tcgagcgcac ccgcgaagag ggctggctgt ccttcgccga
    12061 ccaggcgctg gagcgggaca tcgaggagtg cgtcgagtcc gacgacggct cgcttcaggt
    12121 ccgcgacggt gagacccgga cgctgcccta cgtgggtgtc ggcagcgccg gaatcctgat
    12181 ggtcgccgag gagctggcga agtaccgccc ggacgcgaag gcgctgaaga gccttcccgg
    12241 cctgcgtgaa gcttgccgcg gcgagttcgt catccatccc ggcttgctgt tcggcagggg
    12301 cgggctgatg accgcgctgg ccatgggcgc cgaaccggac cggcgcgccc gcgacgccat
    12361 cgacctgcat ctttcccggc tggcctggta cgcggtgccg tacaagggcg gcctggcgtt
    12421 ccccggcaac cagctgctgc ggctgtcgat ggacgtcgtc accggcggcg cgggtgttct
    12481 gctcgccctc gccgcgaccc tggacgggaa ggccgcgctg cctttcctgt cctccagaac
    12541 tgccgtccat tgaggacggc ggaccaagag ataactagtg aaagggaaca ccatggaact
    12601 ggttctcgac ctgcaggccc tggaagcccc cgaggttctc gacggtggcc acggcggcgg
    12661 cgggcacggc ggcggcagca acctgagcct gctcgcgtcc tgcgcgaaca gcaccatcag
    12721 cctgctgacc tgccactgat cacggtctga tcgatgaagg gcgcgggagc ggcacaggcc
    12781 aagtgcgccg ctcccgcgcc ctcattttgc cttctgcttc gtctcgatgg gatcacgttg
    12841 taaggagtgg gatggcgggt tcagccgatc ggctgctggt cgaggtgacc gcgctcgacc
    12901 gcccccgcct ggtcgcgctg gtgctcagcg cgctcgccgg gacggcgtcg ggactgctcc
    12961 tgccaggagc gctcgcggcc gccgtcgacg ccgtcgtggc cggacgtccc agcttccccg
    13021 aagtctcctg gctgctctcg ctcgggatcg tcgagatcct cgtcggactg atcggcggga
    13081 tcctttccgc gcggatgacc agttccgcga cggcctggct gcgccgtcgg ctggccgatc
    13141 gtcatctcgc gctcggtacc cgttcgacat tcgccgacgg tgacgcgatc agcaggctca
    13201 ccggtgactg caccggcgcc ggactggtcg cctcggtcgt cgtccagctc gggtcgacca
    13261 cgctgatctc cggcggatcc gtcgtcctgc tcgcgctgat ggactggcgg ctcgcgctcg
    13321 tcttcctcgg cagcatcccg ttcggactga tgctggcgcg cacccatctg aagaacaccg
    13381 ccgacgacgt cctgacctat caggaggttt ccggcgaact ggcggcgagg atggtcgacg
    13441 ccgtcgccgg gctccgcacg atcgccgcgt cgggcaccgc cgaccgcgag gccgaacgcg
    13501 tgctgcggcc gctgccgaaa ctgagcctcg ccggccgcgg gatgtggcgt acgcaggcca
    13561 ggatggtgtg gcgttccggg ctgctgctgc ccgcggcgga actcgcggtg ctcgccgccg
    13621 ccggtttcgg cgtgctggag ggcaggctga ccgtcggaca ggtcctcgcc gcgctcggct
    13681 acgtcgcgct cggcatgggc ctggtcaccc agattccttt gctcaccaca ctttcccgcg
    13741 cgcggtcgtg tgcgcggcgg atcaacgagg tgctggactc gccggtcccg gaaccgggcg
    13801 acctcagcat cgtccccggc cggggcacgc tcgaactgcg cgaggtcacc gtcgaaggcg
    13861 cgttgcggga cgtcgacctg ctcgtccgag gcggccgctt caccgcggtc gtcgggcggt
    13921 ccggttcggg gaagtccgcg ctggtcaacg tcctcggcgg cctgctgacc ccggacgagg
    13981 ggacggcgac gctcgacggc cgcccgctgg agcggctgcg gccttacgaa ctccgtgcgg
    14041 tcgtcgggtt cgccttcgaa cggcccgcac tgcacggcgc gaccatcggc gacgccgtcg
    14101 ggtacggctc gtgggccggt gaggccgccg tgcggggcgc ctgccggtcc gcacaggtcg
    14161 acgacctcat cgtccggctg ccggacgggt accggacgcc gctttcggag acgccgctgt
    14221 ccggcgggga ggcgcagcgg atcggactgg cgcgcgcgat cgcgcacgcg ccgagggtgc
    14281 tcatcctcga cgacgccacc gccagcctcg acacggtcac cgaagccgcc gtcgaagaag
    14341 cgatcgaacg caccctgccc ggcaggacac gggtggtggt gacccatcgc gcggccaccg
    14401 cggcgcgggc ggacatggtg gtgtggatgg aagacggccg ggtccgcgcg gtcggcccgc
    14461 acgggcagtt gtggcggaac ccggtctacc aggctgtttt caccgagggc gcgcagtgag
    14521 cgtctggggg ctttaccgct cggcgctggc cgggcagtgg cgaggcgggc tggtcctgct
    14581 ggcctgctcc gtactggaga gcgcgcccgc gttcttgtcc ggtcgcctgg tcgaactcgc
    14641 ggttgacgag gggtttgccg cgggtcggcc aggcaccgga ctgcgttggc tcgcggtctt
    14701 cgggctggtc gccgtgctcg gggcgttcgg ttcacggctg gtgtggcatc agctcggcaa
    14761 ggtcgtcgag ccgttgcgag acgcgctggt gacggcggtc gtccgcgggg tcctgcacga
    14821 tccggcgcca ccgcggaacc agccggacgc cagcggtgtc gcccgcatca cccagcacgt
    14881 cgaggtggtc cgcgacgcca cggccgggtt gctggtgcag gcgcgcggga tgatcgtgac
    14941 gacggtggcg gcgctggccg ggttgttcac cgtcgccggt tcgctggcgc tgatcgtcgc
    15001 gatcccggtg gtggtcgcgg tcgtcgtgtt cgcctgcctg ctcccgtcgc tggcccgccg
    15061 ccagcgggcg ctcgcgctgg ccgacgagcg gaccgccgag gtcgccgggg cgacactgtc
    15121 cggcatgcgc gacatcgtcg cgtgcggcgc cgaacccctg gccgcgctcg atctctacga
    15181 cgccatcgac acacaggcca aggcggcggt ccgggtggcg aggtccgggg cggcgcgggc
    15241 ggtggtgatc gccgcaggcg ggttcgtgcc gctgctgctg gcgttgctgg tggcgccggg
    15301 gctggtcaag gacggcgtgc tcaccgccgg ggccgcgctc ggcgcgctcg tctacctggc
    15361 gacgacgatg caaccggcgt tgcgggggct gggcgcgacc gcgagcaccg tggtgctgag
    15421 gctgatcgtc gcgttgcgac ggctggcgga gaccgcgcag gccgagccgg aggccgacgg
    15481 caccgccgaa cccgacggga ccgcgatcta cgtgcgcgac ttgaccttca gctggggcgc
    15541 ggcggcggaa ccggtggtgc gcggtctcga cctgcatctg cggcccggtg agcggctggc
    15601 ggtggtggga ccgagcggaa tcggcaagtc gacactggcc gggctcctca ccgggatgct
    15661 cgaaccgcag gcaggccggg tgctgctcgg cggggtcccg gtccgggaga tcccggcggc
    15721 gctacggcac cggctggtcg cgctgatccc gcaggaggcc tacgtcttcg cggggtccgt
    15781 gcgggacaat gtaggcctgt tcgcgcagac cgcgatggac ggtgaactgc tggcggcggt
    15841 gacggccgtc ggcgcggaac cgctggtcac ccggctgggc gggctcgacg gcgagatcgg
    15901 gcacggcacg ttgtccgccg gtgaggcgca gctgatcgcg ctcgcgcggg tgtacgcgag
    15961 cgacgcggac gtcatcgtcc tcgacgaggc gacgtcgcat ctcgacccgc ccgccgaagc
    16021 ccgcgcggaa cgggcgttcg ccgaacgggg cggggtgctg gtggtgatcg cgcaccggct
    16081 gacatcggcg ttgcgcgcgg accgggtcct ggtgatggac ggcaaggaaa cggcgctggg
    16141 cacccacctc gaactcatgg accggtccac gcgctacgcc cagctcatgc acgcatggtc
    16201 gccgcggcta ccccagccca gcgcgcagtt cttccagcgc gcccctgagt agaccctcga
    16261 cgggaaccgg gcgccgggac tctcgatcga cgaagacgtg cacgaaacgc ccctccgcga
    16321 tcaccgtctc cttcgagtac atcccgacct cgtagcggac gctggaccgg ccgaggtggc
    16381 ccacccgcag tccgacctcg agttctccgg ggaacgacac cgaagcgtgg tacttgcact
    16441 gcgattccac gcacagcccg atgacgccgc cggtctcgat gtcgagcccg ccgcgttcga
    16501 tcagccacgt gttgatcacg gtgtccatca ccgaatagtg gacgacgttg ttgacgtgcc
    16561 cgtagacgtc gttgtccttc caccgcagcg gaaccgtctg ccagtgcggg tactcggcgt
    16621 tcaccacagc gtcaccgaat cccgcaggat cccggcgagg tcctcttcgg acgcctcacg
    16681 cggcgccgtc gccagcagcc gttgctgttt caccgtgccg gaaaccagtg agtctacatc
    16741 ggactcggcg tagccgacgg cgccgatgcc gttggggatc ccgatctccc gcatgatctg
    16801 ccgcagcacc gcgggcaggt ggtcgcgcag atcgcccggc cattcgtagt ccggcgcgag
    16861 cagcctggcc acccgctcgt gccggtccgg ggcggcgtcg aaggtgaacc ggaacgccgc
    16921 gggcgcggtc agcgagaccg ccatcccgtg cggcaccatc gcttcctcac ccggataccc
    16981 ggacggatga aagtcccgga cctgcccggc gatcggatac gcgttggcat gcgggatgtg
    17041 cacgccggcg ttgccgaagc cgagcccggc gaacgtcgcc gcgagcgcca tcgcctcgcg
    17101 cgccttcagg tccgagccgt cccgcacagc cgcgggcagc gcccacgaca gcagccgcag
    17161 cgactgctcg gcgaacatgt cggccagcgg attcgagcca cagtaaggaa cccggtcctc
    17221 gggtcgcttc cggtcgaact cggtgtacgg cttggcggtg tagctttccg cggcatggca
    17281 aaggatgtcc atcccgctcg cggcggtgac ctccggcggc tgcgacacgg tcagcctcgg
    17341 gtcgaccacg gcgaggctcg gccgcagccg gagatggctg atgccgctct tcactcgcag
    17401 tgacaacacg tccagcacgc agaccgtggt gctctccgag ccggtcccgg tggtggtcgg
    17461 caccgcgacc agcggtttca gcggcgcgct cggcgcccgg ccgccgccga ccggggcgtt
    17521 gacgtagtcc agcaggtcgc cgtcgttgct ggtcagcagg tttaccgcct tggcggtgtc
    17581 gatggccgat ccgccaccga cggcgacgaa ggcgtcccac tcgccctgcc cgcgggcgaa
    17641 gtcgacggcc ttccgcatgc tgacgtcggt cggctcgaca tgcacgccgt cgaagacgac
    17701 cgcttcaatg ccgtacgtct cgatgccttc ggcgatccgt tgtggccagc ccgtggcggc
    17761 gacgtcggcg tcggtcagga cgagtacccg gcgggcgccg tactgcgtga ggtcgtagcc
    17821 gatctcatca ctcgatccgg tgccgtattt caaggccggg gccccgtaag tgaaaacagt
    17881 ttcacgtccg gcggtggctg aggtcacgtt ttcgtgctcc cttgctcgaa cacgttccga
    17941 tatcggacat tccgccgctc cggggttgcc ggaatcggaa gatcgcttga cggcaccgat
    18001 caccgcccgc ctaagctcat ctcattagat accaaccggg agcgtccgtc gcccagacgg
    18061 ccgtgcggat cctgaccgag gcgcagatcc accgcgtgta cgcggtggcg ggtgagtcct
    18121 tcctggatct gctcgacgcg ctgcagcgcg agcggtcgat caccttcgtt tcggcgaggc
    18181 acgactccgg cgccgccttc atggccgagg ccgagggcaa gctcaccgaa catccggcgg
    18241 tactgctggc aggccggggg ccgaacgcgg cgaacctcgc gatcggcgtc tcgacggcgt
    18301 accaggacga gagcccgatg gtcgtcctcc tggagaaccc gccgtccagc cccggcccga
    18361 ccagcgagct gcccaccgcg gacctgaccg cgatgttcga gccgatcgtc aagtggaccg
    18421 gccgcgcgga atccccggac gaggtccccg gcctgctggt cgaggcgctg acccgctgcc
    18481 gggaagggcg gccggggccc accgtcgtcg ccgtccccgc cgacttctgg ggtgtcccgt
    18541 tcgattcggc gaaaccggtc gccgccgtca aggcgcccgc caccggcgcg ctcggccgga
    18601 ccgccgaggc ggtcgcgcag ctggtcgacg aggcccgcta cccggtggtg atcgtcggcg
    18661 gccgggcccg cgcggcacgg gaagagctga tcgccgtcgc cgacgaactc gcgctcccgg
    18721 tgtacaacgc gttccgccgt caggacgcct tccccgagaa ccacgcgcgc tacgccggcc
    18781 acctcggcat cggcatcccc gcgcggcagc tcgacgcgct ggagcgcgcc gacctggtgc
    18841 tcgcgctggg cacgcagctc gacgaggtca ccacccagtg cttccgctac ccgacgccgt
    18901 cgcagacgct ggtgctggtc ggcaccggga tcgagcccgc ccggcgcggc ggcctgacct
    18961 tccgggtcga ctccgaggtc gagccgttcc tgcgagaact gcgtgacgtc gcctcgccac
    19021 gacagcggcg cgcgtcggcc gcgaacgccg ccgtgcacac cttcatgacg ccgcccgaca
    19081 ccagcggcgc cacccgcgtc caccccgccg acgtcatccg cgcggtgcgc aaactcgcac
    19141 ccgaagacgc gatcgtgacc agcgacgcgg gcaacttcgc ccagttcatg caccgttact
    19201 ggtgcttcac cgcaccacgc agtcagctcg gcccgagcaa cgcggccatg gggtacgcgg
    19261 tccccgcggc ggtcgcggcg aaactcgccg agccgcgccg gacggtgatc gcgatggtcg
    19321 gcgacggcgg cgcgctgatg accgggcaag agatcgagac cgccgtccgc taccgggtgc
    19381 cggtgaccgt cctggtgttc cagaacggac tgcacggtcc gctcgcggtg caccaggcgc
    19441 gcaagcacgg gcggctgtcc ggggtcaccg tccccgtcac cgacttcgcg tcgtgggcac
    19501 gggggctcgg cgccgccggg tacaccgtgg acgaccgcga gcagctggag ccgatcatcg
    19561 cgagcgcgct ggtccggcaa cggccgtgcg tgatcgacat caggacggat ccggacgtgg
    19621 tgaccccgga catccggctg acgagcctgc tgggcgccgc gaggccgcag caggggcagc
    19681 agtaggggcg cggttttctc aggggataca cagaaaccct tgtggcgtcg ccttcacctg
    19741 ctccaaaggg tgggaacgag atgacgactc ggccgacatt cggtcgcgga gaccggattt
    19801 tgtcggtcgg ccgtggcaca atcgccgcaa caccgagagt ccgataagga ccggagtgat
    19861 caccggtggg gttgttggca cgcaagtaca tcgcacgttg tgttgacact gggagaaaac
    19921 atggctgacg agacgaagcc acaggacagg tccgtttccg gcgtggtgcc ggtgctgttc
    19981 agcgcggacg cggagaccca cgacatcgcc gtcgtggcca cgaaccggga ggcgttgcgc
    20041 cgttcgccgt tcggcgccga agtaccgttg cgcgcggcca gcggcgaata gctgggccga
    20101 acagggtaca gtgcggctgc gcacacccga gtgaaggtcc ttgtcgggcc gcttgtggtg
    20161 tgctttactg ctccaggtct cgatttttgt gttcgtgttg gttcacgctc gcagaactca
    20221 gcgggcgtag tgtctcctcg tgtttccggg gaagcaaacc gtctggtcat gactcgggct
    20281 gccgacgtgg cttcctgttt gtttgtgttg catatggaga ttttatgact cagggcactg
    20341 tgaagtggtt caactccgag aaggggttcg gcttcatcac tcccgacaac ggcggcggcg
    20401 acgtcttcgt gcactacagc gagatcaagg gcaacggttt ccgtaccctc gaggagaacg
    20461 cccgcgtgga gttcgaaatc gggcagggcg cgaagggtcc gcaggccacc tcggtcaccg
    20521 tgatctgatc caggttttcg aagcagggcc gccgtcccct cggggaggcg gccctgctgc
    20581 ttttccacgg tcggactgac caaaatggcc ttgttcacac tgcaagtcgt gatgcaacgt
    20641 cgtgcaactc tttctttccc ggccctgacg tcgtttcctt atagggactt ggcgcggcag
    20701 cggaggacat gtgggcgaag cggttgcggg gatcgtggcg aaccccgctt cggagcgtga
    20761 catccagagc ctgcgctcgg cactccgcgt ggccggggtc ggccgggtga tggtgtggac
    20821 cgaggcgggg aagatcatcg gcaccgtccg ccggatggtg gacgcgggcg cgagcgtggt
    20881 catctgcctg ggtgacgacg gcctgatgcg ggccgccgcg gccgcctgcg gcgacgtccc
    20941 gctgctcatg ctgccgaccg gcagcaccga cacgctgccc gagcccaccg tcgccgggct
    21001 cgccgcgggc ctgctggcca cccatcaggt ggacgcggac ctggtcacga accgtgcgac
    21061 catcctcgaa gtcgtcacga aggcccgccg cgagatcgcc ctgaacgacg tcagcgtgtg
    21121 ttcggagagc cggtgggatc ccgcgtcgct gaccgagctg tactgcacgt tcgccgtacc
    21181 ggacggcatc gggctgtcga gtatccccgg acggctgtgc cccagcccca agtccactgt
    21241 ggacggcgtc gcggtctcgc tcggaccggt cgaggagaca ccgtacgtcg tgcaggcgcc
    21301 gatcgcgccc ggcgaagtcc ggtcggtggg tgtccggggc tggagcgtgc tggatcccgg
    21361 cgtccgcgtc gacctcgccg ccggcggtgg ttccatcgcg ctcgacggcc agccgcattt
    21421 cgtgctcagg ccgggagaga gcgctttcgt cgagctcaag cccgacggtc cgtggtgcgt
    21481 cgacgtccgt gccgtgatgg ccgaggccac caggaccggc ctgctgctgg gacgacggcc
    21541 gcagggggcc tttcccaagt accacctggc ggacgcgccc ttcaccgggt gagccgcgcc
    21601 tgaacctcca cccccggctc aacccggcga cggtcccggt ccacccctcg gcgtgcctaa
    21661 cgttcgatcc atgggaaaaa tgaacgtgaa aggcctgttg gggctggtag tcatcggtgt
    21721 cgtcgtcctg ctggggttcc tggcgtatcg cctgatcctg gtcgagatga tcacgcggct
    21781 gagcgatcac tgagggggac gatggggaaa cgtgaaaggc cgctcctgcc ggacacgatc
    21841 gcgccgagct ggctggtcgt ccagctgctc ggcacggccg cggtcgtggt ggtgctgctg
    21901 accgcacgcg agtccagtgc ctggatctgg gcggcgtacg gcgtctgcgg ggccggctgg
    21961 ctgggcttcg tggcggcctc cccgcgcttc cctcggacgg cgaccgtgct gctcgcggtg
    22021 gcgagcgtcg cgccgtcgat cgcgctcggc tgggcggagg actcctccgc catcgtgctg
    22081 gcggtggtca cggtcagccg gttcgccacc ctgaccgagc cgtcggtggc cgccatcctg
    22141 ggggtggtgg ggctcgacgc gagcctcgcg gcggtcaccg gcctggtcgc gggcgcgtcc
    22201 gaaccgctgg tgttcggcaa cgtcggcgtg ttgctcgtgc tgatgctgct ggggctgaac
    22261 cggcggcagt acgaggtgca ggcggcgcag gcggccgccc tgctggagca gaccaagctg
    22321 gcgcagagcg aacacacgcg ggcggccgcg ctcgacgagc gcacccgcat cgccagggag
    22381 atccacgacg tcctcgcgca ttcgctgggg gcgctgggga tccatctgga ggtcgccgag
    22441 gccctgctgg ccgagaagtc cgatgtggac ggtgcgctcg gcagggtccg gttgtcccgc
    22501 cggctggcgg cggacgggct cgccgaggcg cgtgacgccg tcgcggcctt gcg
//
