LOCUS       NZ_KB913032            22035 bp    DNA     linear   CON 28-APR-2024
DEFINITION  Amycolatopsis alba DSM 44262 scaffold1, whole genome shotgun
            sequence.
ACCESSION   NZ_KB913032
VERSION     NZ_KB913032.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Amycolatopsis alba DSM 44262
  ORGANISM  Amycolatopsis alba DSM 44262
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 9811274)
  AUTHORS   Klenk,H.-P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Amycolatopsis alba DSM 44262
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: India
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 44262
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v. 4.24
            finishing_strategy                :: Missing
            environment                       :: Soil
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi10729
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2011
            Isolation Site                    :: Soil
            Cell Shape                        :: Filament-shaped
            Motility                          :: Nonmotile
            Sporulation                       :: Sporulating
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram+
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.05; ALLPATHS v. r41043; Phrap v.
            4.24
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina GAii
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000384215.1-RS_2024_04_28
            Annotation Date                   :: 04/28/2024 01:36:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,988
            CDSs (total)                      :: 8,922
            Genes (coding)                    :: 8,855
            CDSs (with protein)               :: 8,855
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 24 of 67
            Pseudo Genes (incomplete)         :: 49 of 67
            Pseudo Genes (internal stop)      :: 4 of 67
            Pseudo Genes (multiple problems)  :: 10 of 67
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:42:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2226915
            Orig. end                         :: 2248950
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB913032.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 404842
            Source DNA and Organism available from Hans-Peter  Klenk
            (hpk@dsmz.de)
            Source DNA available from Hans-Peter  Klenk (hpk@dsmz.de)
            Organism available from Hans-Peter  Klenk (hpk@dsmz.de)
            Contacts: Hans-Peter  Klenk (hpk@dsmz.de)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22035
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="10"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22035
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22035
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12035](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12035
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(205..219)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            complement(365..2425)
                     /locus_tag="AMYAL_RS0110410"
     CDS             complement(365..2425)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="AMYAL_RS0110410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_020631247.1"
                     /transl_table=11
                     /translation="MTGLRVGVDIGGTFTDLCVLDETGVVAVGKVLTTHDEPARAVEEG
                     LKRTLADAGLDAADVEQFVHGTTLVTNALIERKGARTALLATAGFRDMLEMRREHRYEL
                     YDLLIELPTPLVPRHLRFDVPERILADGTVHTGLDEEYVARLGGELDARGIDAVAICFL
                     HAFTNPAHERRAAEVLRDVAPRLRIALSSEVVPEIREFERASTTVANVYVQDLTERYLR
                     DLERRLHEAGVRPSPHIMLSNGGIATVDTAARHPIRILESGPAGGALAASAIGRAAGVE
                     DLLAFDMGGTTAKLCMISGGTPLVTHEFEVDRKYRLLPGSGLPVKVPVTDMIEIGVGGG
                     SIARIGALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGGMTLD
                     AEGAREAIRSKIAGPLGVSVEAAAWGIHTSVNEDMANAARVHTVERGKDPAKLPMFTFG
                     GAGPVHGAGVARALGAPEMVAPPAAGVLSAAGFLTAPLAFDFVRSARSAVLDLSWDQVD
                     ALFTEMEAEGGELLEKSGVDGAKVTHRRIAEMRYSGQGYEIRVPVEPGNWPESLIGAFT
                     ETYRTLYRRTGPDVGIEVLNWRVVSSGPAPEVTLELAGAEAEGDARKGSRPAYFPAEGG
                     FVDTAVFDRYLLKPGDRVEGPAIVEERESTVVVPPGARCVVGEDASLVVTV"
     gene            complement(2422..4053)
                     /locus_tag="AMYAL_RS0110415"
     CDS             complement(2422..4053)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028451.1"
                     /locus_tag="AMYAL_RS0110415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_020631248.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.9e-55, bitscore:
                     185.5, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.5e-27, bitscore:
                     93.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPTGAQHLVDALTALGTEVVFGLPGVHNLPLWEALADTDIRLV
                     GVRHEQTAGYAADGYARATGKLGVALVTTGPGAANTLAAVGEAMASAAPVLIIATDIPS
                     TLRRPGVVRGVLHETSDQQAMFAPVTKAGFTVPSADQVAATLHRAARLALQPQSGPVYL
                     GIPTDFLSERTPARRPPRSHARPSEIPDLTEAEALLATADRPLIWAGGGALRAEAGEAI
                     GKLAERLAAPVLTTFGARGLLSVDHPCLAPNPVHAPEVGALWDEADVVLAIGTDFDGLM
                     TQNWLMPQPKKLIAINVDPDDAAKNYQPDITLVGDAKVLTEALKVEERSGIAALVGRLA
                     KVSARVRQRIKEEEPQAADLLSTLDEVLPPDAVVVADMCVAGYWIGGFHRVRAPRKLAY
                     PMGWGTLGYGFPAALGAGAAGTGRAICISGDGGFLFGCGDLATLAQEQLPVTVIVVDDG
                     GYGMLRYDQDRAGLPRRGVDWDSPDFVGLARSFGVHADRVSGFGRAFRRLLGEFVESDE
                     PNVLVVRAKMAPPLNTSPRWYRKGSS"
     misc_feature    complement(3955..3957)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4102..4728)
                     /locus_tag="AMYAL_RS0110420"
     CDS             complement(4102..4728)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033792.1"
                     /locus_tag="AMYAL_RS0110420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_020631249.1"
                     /transl_table=11
                     /translation="MSDGIIEVTTEAELREILPPPLERTANKARPKLHELDRRWLAESP
                     FVLIATSAADGTCDVSPKGDPAGFTLVLDDTRIAIPERPGNRRADGFHNILSNPHVGLI
                     YLIPGRGDTLRINGRARLVREAPFFGDMVVNGSRPKLALVVDIDEIFHHCQKAFMRSKL
                     WSPENWTPDAMPSRAAIAKTFERPEESMADLEAYYEPGRYAAGLY"
     gene            complement(4721..5878)
                     /locus_tag="AMYAL_RS0110425"
     CDS             complement(4721..5878)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="AMYAL_RS0110425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_020631250.1"
                     /sec_met_domain="DAO (E-value: 2.5e-69, bitscore: 233.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPLPERTDVVVIGGGIIGVACAYRLAAAGVSVLLLERDTLGAGS
                     TAKAAGGIRSSFTTHVNIEIGLRGLAEYASFAQTYGTEIDFRRDGYLYLVTDPADLPEF
                     ERCAELQNSYGVRSRLVEPAEARRFSPLIDTEGVVAALWSPDDAKATPDSAVQGYARAA
                     RGHGAVLKTGVEVVGIERDGDEITGVRTTDGFVRTNAVVCAAGAWSGRIGEFAGVDLPV
                     RPFRRQVVFTGPVTDLPASVPLTIEMPSAFYFHREGLGLAMSFCDGDGDPGFDTRYQPG
                     DWLPKLAEIAARRVPAVLNAGIRSGWAGLYEVTPDRNQIVGESVQLSRFFYATGFSGHG
                     FQMGPAVGELVRDLYLGRVPAIDITGLDVRRFDGDRAATREHNIV"
     gene            complement(5862..6875)
                     /locus_tag="AMYAL_RS0110430"
     CDS             complement(5862..6875)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033794.1"
                     /locus_tag="AMYAL_RS0110430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_020631251.1"
                     /sec_met_domain="GST_C (E-value: 1.3e-06, bitscore: 27.5,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTDPQTGEFRRSANHFDARITADGRDGWPAEAGRYRLVVSRA
                     CPWASRALVVRRLLGLESALGVAVADPIQDDKSWRFTLDPDGRDPVLGIKYLAEAYHAA
                     DPHYMGGISVPAIVDIPSKRLVSNDYPRITLDFSTEWTSLHRPGAPDLYPERLRGEIDD
                     VNMGVFADVNAAVYQAGFATKQAAYDDAYHRLFAMLDALSDRLERQRYLVGDTITEADI
                     RLFTTLVRFDSVYHGHFKCNRNKLTEQPVLWAYARDLFQTPGFGDTVDFDHIKRHYHAV
                     HEQVNPTRIVPLGPDLSGWTTPHHREQLGGRPFGDGTPPGPPPEDERIGDTDGATS"
     gene            6972..8348
                     /locus_tag="AMYAL_RS0110435"
     CDS             6972..8348
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150531.1"
                     /locus_tag="AMYAL_RS0110435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_020631252.1"
                     /transl_table=11
                     /translation="MPFMPVTDSMFLLVETREHPMHVGGLQLFKKPEDAGPDYLRDLRR
                     KLLDSDNMRDVFRRRPARPVNTAGHVAWATDNDLELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEIHLVEGLQDGRFAIYSKIHHALMDGVSALRHLQGTLSDDPTDLD
                     CPPPWGRRPKPDGGRNGKASPSVLSTFGKTVNQLAGIAPAAMKVAREAFQEHTLTLPAQ
                     APKTMLNVPIGGARRFAAQSWSLDRVRKVATAAGVSRNDVVLAMCSGALRDYLMEQNAL
                     PDAPLTAMVPVSLRRKDSVDAAGNNIGALLCNLATHLTDPAARLATINASMRNGKKLFS
                     ELTPLQTLLLSGINVAQLGVSPIPGFVNNTKPPFNLVISNVPGPRKQMYWNGASLDGIY
                     PASVLLDGQALNITLTSNGDNLDFGVTGCRRSVPHLQRILTHLDTALAELEHAVSIGRS
                     "
     gene            complement(8501..9487)
                     /locus_tag="AMYAL_RS0110440"
     CDS             complement(8501..9487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="AMYAL_RS0110440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_020631253.1"
                     /transl_table=11
                     /translation="MSLRRTLATTFAAATAVSIAAVPAAATEAPSVQAIKQIASGLNQA
                     WSIDFLPDGTGLFTQKDAKTISKIDKAGKVTTVQTIAGVSVTPEAGLLGIAVSPKYATD
                     QTVFIYYTTSSDNRIAKLKLGQTPKPIVTGIPRGANFHHGGRIRFGPDGYLYAGTGDGQ
                     NGANAQNKNSLGGKVLRVTTDGAPAPGNPFNSRVYSYGHRNVQGLTWVNGQLYVSDIGA
                     NKLDELNKVEPGKNYGWPTCEGPCDTAGMTNPVKAWPTAVATPSGLAAYKGSLYMASLK
                     GGTFKLDLNGNGDKLWTNLGRTRDATAGPDGQLYTITPGAIYVSDGS"
     misc_feature    complement(9479..9481)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9691..9703)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            9801..9896
                     /gene="pqqA"
                     /locus_tag="AMYAL_RS0110445"
     CDS             9801..9896
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="AMYAL_RS0110445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_007033797.1"
                     /transl_table=11
                     /translation="MIETIEVWTTPDFVEYETPMEVTAYAARMED"
     misc_feature    9815..9830
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 21.0"
                     /tool="antismash"
     gene            10001..10681
                     /gene="pqqC"
                     /locus_tag="AMYAL_RS0110450"
     CDS             10001..10681
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336983.1"
                     /locus_tag="AMYAL_RS0110450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_020631254.1"
                     /sec_met_domain="TIGR02111 (E-value: 1.2e-84, bitscore:
                     282.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSEFVAALRGLSHRYWGTHPFHRRMHDGGLSEYELKIWAANRW
                     YYQCVLPQKDAAIISNCPVPEIRREWLDRIVYHDGAKAGDGGIERWLRLCAAVGLDREE
                     VLDQRHVAPGVRFAVDAYVNFARTRPWLEAVASGLTEMFAGHLMQRRVADMLANYSWIA
                     REDLDYFTNRIDKVSGEGKGTLDIVVRHAVTREQQEKAIAALSFKTDVLWSMLDAIERA
                     AAKE"
     gene            10684..10956
                     /gene="pqqD"
                     /locus_tag="AMYAL_RS0110455"
     CDS             10684..10956
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="AMYAL_RS0110455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_020631255.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.7e-23, bitscore:
                     80.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.6e-09, bitscore: 36.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLEMGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAV
                     LTLCDGVEDVAAIASALRKRYAGVREEEILDVLSRLGDRRIVEWT"
     aSDomain        10690..10947
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AMYAL_RS0110455_PqqD_RRE.1"
                     /evalue="8.50E-26"
                     /identifier="RREFam006.1"
                     /label="AMYAL_RS0110455"
                     /locus_tag="AMYAL_RS0110455"
                     /protein_end="88"
                     /protein_start="2"
                     /score="80.5"
                     /tool="antismash"
                     /translation="TLEMGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAVLT
                     LCDGVEDVAAIASALRKRYAGVREEEILDVLSRLGDRRIVE"
     gene            10947..12035
                     /gene="pqqE"
                     /locus_tag="AMYAL_RS0110460"
     CDS             10947..12035
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150538.1"
                     /locus_tag="AMYAL_RS0110460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_020631256.1"
                     /sec_met_domain="PF04055 (E-value: 1.2e-20, bitscore: 73.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.2e-06, bitscore: 25.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.4e-09, bitscore: 37.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.4e-11, bitscore:
                     42.9, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNTSTAAPPLGMLAELTHRCPLHCPYCSNPVELIARDGELSTK
                     EWLSVLTQARELGVLQVHMSGGEPLARPDLPILVEHATKLGCYVNLVTSGLGLTESRLD
                     DLAERGIAHIQLSVQGATAERADRLAGARAHDRKLVVAGLIKKAGLPLSVNVVLHRQNH
                     DQLAGIIDLAEKMGADRLELANTQYYGWALRNRDALMPTRRQLDEAEPIVRAATERLRG
                     RMEIIYVVADYYEQYPKPCMYGWGARQLTVAPDGNVLPCPASTAIETLEFDNIRDKPLA
                     RIWYESSSFNAYRSEDWMSDTCGTCERRAIDFGGCRCQAFQLTGDASATDPVCSRSPDR
                     GIVDLILATPPKADELVMRGPR"
     gene            12032..12895
                     /gene="pqqB"
                     /locus_tag="AMYAL_RS0110465"
     CDS             12032..12895
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="AMYAL_RS0110465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_020631257.1"
                     /transl_table=11
                     /translation="MRVILLGTAAGGGFPQWNCACALCVSDAPPRTQDCVAVSADGKGW
                     YLLNASPDIRAQILATPALRAGPGPREIPLRGVLLTDAELDHSLGLLLLREAGGLPVWA
                     PDAVLGALSEQFPARSIIDGYGGWDWLPSSEVSIDGLRVSALPVSDKRPKYARSSAEDG
                     PWVVAYRIEDVETGGVLVYAPCLKSWPDGFDDFTRDAGLVLLDGTFYAPDEMSGATATK
                     VGDGAQLAMGHLPITGSLAKLRPGPRWAYTHLNNTNPVVDPSSPEHAAVLDGGASLPLD
                     GSEFKL"
     gene            complement(12892..13866)
                     /locus_tag="AMYAL_RS0110470"
     CDS             complement(12892..13866)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082804.1"
                     /locus_tag="AMYAL_RS0110470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_051137517.1"
                     /transl_table=11
                     /translation="MRTTTLGRSGLEVSRIAFGTWQLGGGWGSFDEDSAIAAIHHAREL
                     GATFFDTAQAYGFGKSEALLGKALREELKRDRDNLVIATKGGTKPRSERPRDSRREWLT
                     QGIEDSLRFLDVDHIDLYQIHWPDPGTPAEETAGILQEFVDAGKIRHIGVSNYDAAALA
                     DFDKTRPVETLQPPYHLFRRDIEIDPLPYARENDIGVLVYSPLGSGLLTGSLTAETTFE
                     KADWRSQSSAFTGETFRRNLAIVDRLKEFAADKGISVSQLAIAWTLARPGVHVAIVGAR
                     KAANIEASLAAADIDLSADELAEIDRLTADAVPVAGASPEGIA"
     misc_feature    complement(13928..13941)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            13976..14494
                     /locus_tag="AMYAL_RS0110475"
     CDS             13976..14494
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005447463.1"
                     /locus_tag="AMYAL_RS0110475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_020631259.1"
                     /transl_table=11
                     /translation="MSESPALDGLRVLAHPIRLRVLSLLTGVAMSAAEVARELGETQAN
                     VSYHLRRLHEAGLLDIVEEVRIRGGLAKRYRHDPESGSWFTSTNPHEEQLLLATMAEEL
                     KRRGEFRVPGQRGSTTDTEIWVDRETWEKALEQARELGELLHSAAKPPRTRGTIPVSAT
                     VSMFEMRRR"
     gene            14491..15711
                     /locus_tag="AMYAL_RS0110480"
     CDS             14491..15711
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033804.1"
                     /locus_tag="AMYAL_RS0110480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_020631260.1"
                     /transl_table=11
                     /translation="MTSLREPLRHHNFRWLVGGRTFGEFGNAVAPLALAFAVIDLTGSA
                     VDIGIVVGARSVASVVLLLFGGVLADRLPRSVILQGTELAATLTQAVIAASVLCGFASI
                     PLLVGLSVVNGAVAAISAPASASLTPLTVPATLLAQANALGRLLSNSGRIAGAGLGGIL
                     VTAVGPGWALGGNALLFLGSALSYRRIRLSRRERLPGSRPLAELAEGWREFRSRTWVWV
                     VVVQFMVVNAVIAGGIAVLGPVVADSSFGRSGWGFALAAQTIGSLVGGILVARWQPRRA
                     LFVGVAVILFEAPPLILLGQAPWLPLLLAAMFVSGLAIEQFVVAWDVSLQENVPEDKLA
                     RVYSYDMLGSFIALPLGQMAAGPAAQHFGVSTTLLACAALVVAATCLALCSGQVRGLVR
                     KTHATHP"
     gene            complement(15754..17130)
                     /locus_tag="AMYAL_RS0110485"
     CDS             complement(15754..17130)
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150551.1"
                     /locus_tag="AMYAL_RS0110485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidase"
                     /protein_id="WP_020631261.1"
                     /transl_table=11
                     /translation="MNDIKLTASELVAAYATGELSPVEATQNALRVIEERDDEINAYCL
                     VDAEGAIEQAKASEVRWRDGNPIGWLDGVPASIKDMFLTQGWPTLRGSRCIDPDQPWDV
                     DSPVTARLRENGLVLLGKTTTPELAWKGVTDNTLTGITRNPHDLSTTAGGSSGGSAAAV
                     AAGMGELSVGTDGGGSIRIPASFCGIVGLKPTHGRIPLFPASPFGPLSHAGPMARSVDD
                     TALLLDVLAMPDYRDPAALAPPVSTFREAVRRDVRGLNAAYSPTLGYVDVDPEVAAIVK
                     SAVQSLGDAGLYIEETDPGFTDPKPAFDILWSTGAAKWLDTFPAGSETKVDPGLRKVWE
                     SGKTFSASDYLGANAERAALGILMGEFHTRYDVLITPTLPIAAFEAGHEVPPGSGLSGW
                     PDWTPFTYPFNMTQQPAISVPAGRTSSGLPVGLQIVGPRHSDDLVLAVAKLLEEVRPWP
                     "
     gene            complement(17138..18127)
                     /locus_tag="AMYAL_RS0110490"
     CDS             complement(17138..18127)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336991.1"
                     /locus_tag="AMYAL_RS0110490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_020631262.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 7.8e-52, bitscore:
                     174.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASETPVLAVLCGDTRPPDMRAIEAEAVVRYTDEAGLADALSGA
                     DAFFVYDFLSTAVPGAWHAADRLRWLHIASAGVDPVLFPGVQQSDVVLTNSRGVFDGAI
                     AEYVLGVVLAFAKDFARSWDLQRQKRWKHRESERISGRRVLVVGTGPIGRSIARMLRAA
                     GMSVAGVGRRPREGDPDFGAVYASSDLGSHLPEADYVVAVAPLTEQTKGMFDAEAFAAM
                     KPGARFVNVGRGELVVTSDLVGALRDGSLGGAALDVFDTEPLPPESPLWTMENVLISPH
                     MSGDFVGWRNTLVEVFADNFRRWRAGEPLRNVVDKQLGYVPSETLRQG"
     misc_feature    complement(18002..18004)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18227..18967
                     /locus_tag="AMYAL_RS0110495"
     CDS             18227..18967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631263.1"
                     /locus_tag="AMYAL_RS0110495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Asp/Glu/hydantoin racemase"
                     /protein_id="WP_020631263.1"
                     /transl_table=11
                     /translation="MDFDLLEFEGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSRHLATATRDVLHVEPEVVAYLCTSGSFVNGVDYERSLTKA
                     ICDAGAPDAVTTSGALAEVLHQLDLHQVSVLTPYDGDLTGKLHDFLAELGVRTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHADADAIFVSCTNLPTYDLIEPLESALGKPVLTANQL
                     TMWACLRRMNLPIVGPGKWLREVD"
     misc_feature    18239..18241
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19012..19782
                     /locus_tag="AMYAL_RS0110500"
     CDS             19012..19782
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033808.1"
                     /locus_tag="AMYAL_RS0110500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="maleate cis-trans isomerase"
                     /protein_id="WP_020631264.1"
                     /transl_table=11
                     /translation="MPISPLTPPEPPSETTTIGFIYPDHAAEDDYPLAEQLLGGDMAGI
                     KLPVEHIYGTDLHAVPELLDLGSESRLADGAALLAKHEPDAVMWACTSGSFVYGWEGAR
                     DQADRLAAVAGVPASSTSFAFVHAAHALRVRRVAVAASYPDDVARLFVEFLGAGGIEVV
                     SMGSADIDTAAEVGELSPEAVVELAASGDHPAADALLVPDTAMRTLGEINTLETRLGKP
                     VLTANQVTVWEGLRLTGRSPLVRTLGALFGQRGN"
     gene            19786..20478
                     /locus_tag="AMYAL_RS0110505"
     CDS             19786..20478
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033809.1"
                     /locus_tag="AMYAL_RS0110505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_020631265.1"
                     /transl_table=11
                     /translation="MSLPDIEPVSRESTAGIIARQLRDAIMTGALPPGTQLGETDLASR
                     FQVSRGPLREAMQHLVSEGLLRSERHRGLFVIDLEPGDVYDIYSARSAIERAAMLRALR
                     GDRERVATELEQAVTAMATAADDDDPTALSWADLRFHEALIAASGSKRLVRMARTLLIE
                     TRMCLTALQGTYQRVEERVTEHTRIIEALRAGDEETALSLLEAHMEDAVQRLAPGTSLR
                     EGEAPAVP"
     gene            complement(20483..20959)
                     /locus_tag="AMYAL_RS0110510"
     CDS             complement(20483..20959)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033810.1"
                     /locus_tag="AMYAL_RS0110510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_020631266.1"
                     /transl_table=11
                     /translation="MCWHCDNPGKTRNDYLIEEVRPLIRKYGWMVQAVDSGGAQPSFAY
                     TVGLTDAGLPELVVTGLRERRSSQLLNYFAQQVVRSGPPESGEVLPAAVGWPAFEVVPL
                     SSPSAHLVTAVLMYGEEFRALQLVYEDEHGNWPWEREFRGGTGGQPVLGARHRG"
     misc_feature    complement(21099..21112)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.31"
                     /tool="antismash"
     misc_feature    21099..21113
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.79"
                     /tool="antismash"
     misc_feature    complement(21100..21113)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.34"
                     /tool="antismash"
     misc_feature    complement(21402..21413)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    21869..21883
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.7"
                     /tool="antismash"
ORIGIN
        1 caggaagcga accacgcgac cagccgtccc cgcaggaaca ccggcgtggc gacggtgatg
       61 tcgttgatct gcccggccgt ctgccacgga tcgttggtga gcaggacgtc gcccggctca
      121 agggtctccg gcgggtacgc ggcgacgaaa tgccgcatcc cggtcgccat cgcgttgatg
      181 tggccggggg tcccgccgac ggactggccg atcatctcac cgcgcgagtc gaacaccgcg
      241 caggcgagat cgagcgattc ccgcaccacg gaggagaacg cggtgttgac gagcgcgttc
      301 tgctgctccg cgaggatcga atgcagccgg tttcccagca caccgaccaa gatcgggtcg
      361 acgctcacac cgtcaccacc aggctggcgt cttcgccgac cacgcagcgc gcacccggag
      421 gaacgaccac ggtggactct cgttcctcca cgatggcagg gccctcgaca cgatcacccg
      481 gcttgagcag ataccggtcg aacaccgctg tgtcgacaaa gccaccttcg gcgggaaagt
      541 acgccggacg agatcccttg cgcgcgtcgc cctcggcttc ggcacccgcg agttccagtg
      601 tgacctcggg tgccgggccg ctggagacga cccgccagtt gagcacctcg atcccgacgt
      661 ccggaccggt ccgccggtac agcgtccgat aggtctcggt gaacgcgccg atcagtgact
      721 ccggccagtt ccccggctcg accggcacac ggatctcgta gccctgcccg gaataccgca
      781 tctcggcgat ccggcggtgc gtcaccttcg caccgtccac accggacttc tccagcagct
      841 ccccgccttc ggcctccatc tcggtgaaca gcgcgtcgac ctggtcccac gagagatcga
      901 ggaccgccga acgcgccgag cgcacgaaat cgaaggccag cggcgcggtg aggaatcccg
      961 ccgcgctcag caccccggcc gccggagggg cgaccatctc gggggcgccg agcgcccgcg
     1021 ccacgccggc accgtgcacc ggaccggcgc cgccgaaagt gaacatcggc agcttcgccg
     1081 gatccttgcc ccgctcgacg gtgtggacgc gggcggcgtt ggccatgtcc tcgttgacgc
     1141 tggtgtggat gccccaagcg gccgcttcga cgctgacgcc gagcggtccg gcgatcttcg
     1201 agcggatcgc ctcgcgggcg ccctcggcgt ccaaagtcat tccgccgccg aggaaatatc
     1261 cgggatccag gtaaccgagc acgaggtcgg cgtcggtcac ggtcggttcg gtgccgcctc
     1321 gcccgtagca gaccggaccg ggctcggacc ccgccgaatc cgggccgacg gtgagcaggc
     1381 cgagcgcgcc gatgcgggcg atcgaaccgc caccgacacc gatttcgatc atgtcggtga
     1441 ccgggacctt gaccggcagc ccggatcccg gcagcagccg gtacttccgg tccacttcga
     1501 actcatgggt caccagcggc gtgccgccgg agatcatgca cagcttcgcc gtcgtgccgc
     1561 ccatgtcgaa ggccagcaga tcctcgacac cggccgcgcg cccgatcgcg gacgcggcca
     1621 gcgccccgcc cgccggaccg gattcgagga tgcggatggg gtggcgcgct gccgtgtcga
     1681 cggtcgcgat gccgccgttg gacagcatga tgtgcggcga cgggcgcacc ccggcctcgt
     1741 gcaggcgccg ttccagatcg cgcagatacc gttcggtgag gtcctggacg tacacgttcg
     1801 cgaccgtggt ggacgcgcgt tcgaactcac ggatctccgg gacgacctcg ctggacagcg
     1861 cgatccgcaa cctcggcgcg acgtcgcgga gcacctcggc ggcccggcgt tcgtgcgcgg
     1921 gattcgtgaa ggcgtgcagg aaacagatcg cgaccgcgtc gatcccgcgg gcgtcgagtt
     1981 cgcctccgag ccgcgcgacg tactcctcgt ccagtcctgt gtggacggta ccgtccgcga
     2041 ggatccgttc cgggacgtcg aagcgcagat ggcgcgggac cagcggcgtg gggagttcga
     2101 tgagcaggtc gtacagctcg taccgatgtt cgcgccgcat ctccagcatg tcacggaaac
     2161 cggcggtcgc cagcagcgcg gtgcgggctc ccttgcgttc gatcagcgcg ttcgtgacga
     2221 gggtggtgcc gtgcacgaac tgctcgacgt ccgccgcgtc cagcccggca tcggcgaggg
     2281 tccttttcag accttcctcg acagcgcgag cgggctcgtc gtgcgtcgtc agtaccttgc
     2341 cgacggcgac gacacccgtc tcgtcgagca cgcagagatc ggtgaaggtc ccgccgatgt
     2401 ccacgccgac acggagcccg gtcacgaaga acccttgcga taccagcgcg gcgaggtgtt
     2461 gagcggtggc gccatcttcg cgcggacgac cagcacgttc ggctcgtcgg actcgacgaa
     2521 ctcgccgagc agccgccgga acgcgcgccc gaagccggac acgcgatcgg cgtgcactcc
     2581 gaaagacctc gccagtccga cgaaatcggg gctgtcccag tcgacgcccc ggcgtggcag
     2641 cccggcgcgg tcctggtcgt agcgaagcat gccgtaaccg ccgtcgtcga cgacgatcac
     2701 cgtgaccggc aactgctcct gcgccagcgt ggcaagatca ccgcagccga acaggaaacc
     2761 gccgtcgccg ctgatacaga tcgcgcggcc ggtgcccgcg gcaccggcgc cgagcgcggc
     2821 ggggaagccg tacccgaggg tgccccagcc catcgggtac gcgagtttgc gcggggcgcg
     2881 gacacggtgg aacccgccga tccagtaccc ggcgacgcac atgtccgcga ccacgaccgc
     2941 gtccggcggc agcacctcgt ccaaagtgga cagaagatcc gcggcctgcg gctcctcttc
     3001 cttgatccgc tgccggacac gggcggagac cttggcgagc ctgccgacga gcgccgcgat
     3061 cccggaccgc tcctcgactt tcagcgcctc ggtgagcacc ttggcgtcgc cgaccagcgt
     3121 gatgtccggc tgatagttct tggccgcgtc gtccgggtcg acgttgatcg cgatgagctt
     3181 cttcggctgt ggcatcagcc agttctgcgt catcagcccg tcgaagtcgg tgccgatggc
     3241 gaggacgacg tcggcctcgt cccacagcgc gccgacctcg ggcgcgtgca ccggattcgg
     3301 ggcgagacag ggatggtcga ccgaaaggag cccgcgcgcg ccgaacgtgg tgagcaccgg
     3361 cgcggccagc cgttcggcga gcttgccgat cgcctcgccc gcctcggcgc gcagcgcgcc
     3421 gccgcccgcc cagatcagcg gcctgtcggc agtggccagt agcgcctcgg cctcggtgag
     3481 atccgggatc tcggacggcc gggcgtgcga ccgcggcgga cggcgcgcgg gcgtccgctc
     3541 ggacaggaag tcggtgggga tgccgaggta gaccggcccg ctctgcggct ggagcgcgag
     3601 ccgggccgcg cggtgcaggg tggcggcgac ctggtccgcg ctcgggacgg tgaacccggc
     3661 cttcgtgacc ggcgcgaaca tcgcctgctg atccgacgtc tcgtgcagca caccgcggac
     3721 cacgccgggc cgccgcagcg tggacgggat gtcggtcgcg atgatcagca ccggcgcggc
     3781 cgaagccatg gcctcgccga cggcggcgag cgtgttcgcc gcgccgggcc ccgtggtcac
     3841 cagcgcgacc ccgagcttgc ccgtcgcgcg ggcgtaaccg tcggccgcgt atccggccgt
     3901 ctgctcgtgc cggacgccga cgagccggat gtccgtatcg gccagtgcct cccataacgg
     3961 caggttgtgc accccaggga gaccgaagac gacttcggtc cccagagcgg tcagcgcgtc
     4021 gacgagatgc tgggctccgg tgggtgcagg caccccgccg atagtgccag atcgttcaac
     4081 gatccagcaa ccatcgtgac gtcaataaag ccctgccgcg taccggcccg gctcgtaata
     4141 cgcctcgagg tcggccatgc tctcctccgg ccgctcgaag gtcttcgcga tcgccgcgcg
     4201 ggacggcatc gcatcgggcg tccagttctc gggcgaccac agcttcgacc gcatgaacgc
     4261 cttctggcag tggtggaaga tctcgtcgat gtcgaccacc agcgcgagct tcggcctgct
     4321 gccgttcacg accatgtcgc cgaagaacgg cgcctcccgc accagccgcg cgcggccgtt
     4381 gatccgcagc gtgtcgccgc ggccggggat caggtagatc agcccgacgt gcggattcga
     4441 caggatgttg tggaaaccgt cggctcgccg gttgccggga cgctccggga tcgcgatccg
     4501 cgtgtcgtcc agcaccagcg tgaacccggc cgggtcgccc ttcggcgaga cgtcgcaggt
     4561 gccgtccgcc gccgaagtcg cgatcagcac gaacggtgac tccgcgagcc accgacggtc
     4621 cagctcgtgc aacttcgggc gcgccttgtt cgcggtccgt tccagcggtg gcggcaggat
     4681 ctcgcgcagc tccgcctcgg tggtgacctc gatgatcccg tcagacaatg ttgtgctccc
     4741 tcgtagcggc ccggtcgccg tcgaaccggc ggacgtcgag cccggtgatg tcgatggccg
     4801 ggacccgccc caggtagagg tcccgtacga gctcccccac ggccgggccc atctggaacc
     4861 cgtgtcccga aaacccggtc gcgtagaaga accgcgacaa ctggacgctt tcccccacga
     4921 tctggttgcg gtcgggggtg acctcgtaca gcccggccca gccgcttcgg atccccgcgt
     4981 tgagcacggc ggggacgcga cgcgcggcga tctcggcgag cttcggcagc cagtcgcccg
     5041 gctggtaccg ggtgtcgaag ccggggtcgc cgtcaccgtc gcagaaggac atcgccaggc
     5101 cgaggccctc gcgatggaag tagaaggccg acggcatctc gatggtcagc ggcacggacg
     5161 cgggcaggtc cgtgaccggg ccggtgaaca cgacctgccg ccggaacggc cgcaccggga
     5221 ggtcgacacc ggcgaactcg ccgatccgcc ccgaccacgc gcccgccgcg cagaccaccg
     5281 cgttcgtccg cacgaacccg tcagtggtgc ggacaccggt gatctcgtcg ccgtcgcgtt
     5341 cgatcccgac gacctcgacg ccggtcttca gcaccgcgcc gtgcccgcgg gccgcccgcg
     5401 cgtagccctg gaccgccgag tccggggtgg ccttggcgtc gtcgggcgac cagagcgccg
     5461 ccaccacgcc ttcggtgtcg atcagcgggg agaaccgccg cgcctcggcg ggctcgacga
     5521 gccggctgcg gacgccgtag gagttctgca gttcggcgca gcgctcgaac tcgggcaggt
     5581 ccgcgggatc ggtgaccaga tacaggtagc cgtcgcggcg gaagtcgatc tcggtcccgt
     5641 acgtctgcgc gaaggacgcg tactcggcca gcccgcgcag cccgatctcg atgttgacgt
     5701 gcgtggtgaa cgacgaccgg atcccgccgg ccgccttcgc cgtcgagccc gcgcccaagg
     5761 tgtcgcgttc gagcaacagc accgagaccc cggcggcggc gagccggtac gcgcaggcga
     5821 ccccgatgat gccgccgccg atcacgacga cgtcggtgcg ttcaggaagt ggctccatcc
     5881 gtgtccccga tccgttcgtc ctcgggcggc ggtcccggcg gtgtgccgtc gccgaacggg
     5941 cgaccgccca gctgttcccg gtggtgcggc gtcgtccagc cggacaggtc cggtcccaag
     6001 gggacgatcc gcgtcgggtt cacctgttcg tgcaccgcgt ggtagtgccg cttgatgtgg
     6061 tcgaaatcga cggtgtcacc gaaacccggc gtttggaaga ggtcacgggc gtaggcccac
     6121 agcaccggct gttcggtcag tttgttccgg ttgcacttga aatgcccgtg atagacggaa
     6181 tcgaaccgga cgagcgtggt gaacagccgg atgtccgctt cggtgatcgt gtcaccgacg
     6241 aggtagcgct gtctctcgag ccggtcggaa agcgcgtcca gcatggcgaa gagccggtgg
     6301 tacgcgtcgt cgtacgcggc ctgcttggtc gcgaacccgg cctggtagac ggcggcgttc
     6361 acgtcggcga agacgcccat gttgacgtcg tcgatctccc cgcgcagccg ctctgggtag
     6421 agatcgggcg cgccgggccg gtgcaggctg gtccattcgg tggaaaaatc cagcgtgatc
     6481 cggggatagt cgttgctcac cagccgtttg ctcggaatgt ccacaatggc cgggacgctg
     6541 atcccgccca tatagtgcgg atcggccgcg tgataggcct ccgccaggta cttgatgccg
     6601 agtaccggat cccggccatc gggatcgagg gtgaaccgcc agctcttgtc gtcctggatc
     6661 gggtcggcga cggccacgcc cagcgcggac tcgagaccga gcagccgccg gacgaccagc
     6721 gcccggctcg cccagggaca ggcccggctg accaccagcc ggtacctccc cgcctccgcc
     6781 ggccagccgt ctcggccgtc cgcggtgatg cgcgcgtcga aatggttggc ggaccgacgg
     6841 aactcacccg tctgcggatc ggtcgggatc gtcatgtgag ccaccctaaa gcgtgagaag
     6901 gtggtttcgg tgtgcgtaga ctctggcacc cggcgtgctc gcacgccgcc gcgcggaagg
     6961 tggtccccac gatgccgttc atgcccgtca ccgactcgat gttcctcctc gtggaaacgc
     7021 gcgaacatcc gatgcacgtc ggcggactcc agttgttcaa gaaaccggag gacgccgggc
     7081 cggactacct gcgggacctt cgccggaaac tgctcgattc cgacaacatg cgcgacgtgt
     7141 tccgccggcg tcccgcccgg ccggtcaaca ccgcaggcca cgtcgcctgg gcgacggaca
     7201 acgacctcga actcgactac cacttccgcc actcggcgct gccccagccg gggcggatcc
     7261 gcgaactgct ggaactgacc gggcgctggc acagcaccct gctcgacagg caccgcccgc
     7321 tgtgggagat ccacctggtc gaaggcctgc aggacggccg gttcgcgatc tacagcaaga
     7381 tccaccacgc gctgatggac ggcgtctcgg cgctgcggca tctgcagggc acgctgtcgg
     7441 acgaccccac cgacctcgac tgcccgccgc cgtggggccg ccgccccaaa ccggacggcg
     7501 gccgcaacgg caaggcgtca ccgtcggtgc tcagcacctt cggcaagacg gtcaaccagc
     7561 tcgccggaat cgcgcccgcc gcgatgaagg tggcgcgcga ggcgttccag gagcacacgc
     7621 tcacgctgcc ggcacaggcg ccgaagacga tgctgaacgt gccgatcggc ggggcccgcc
     7681 ggttcgccgc gcagtcctgg tcgctggacc gggtccggaa ggtggcgacc gccgccgggg
     7741 tgtcacgcaa cgacgtcgtc ctcgcgatgt gctcgggcgc gctgcgggac tacctcatgg
     7801 aacagaacgc gctccccgac gcgccgctga ccgcgatggt cccggtttcc ctgcggcgca
     7861 aggacagcgt ggacgcggcg gggaacaaca tcggcgcgct gctgtgcaac ctcgccaccc
     7921 atctgaccga cccggccgcg cggctcgcga cgatcaacgc gtccatgcgc aacggcaaga
     7981 agctcttctc ggagctgacc ccgctgcaga ccctgctgct gtcggggatc aacgtcgccc
     8041 agctcggcgt ctcgccgatc cccggcttcg tgaacaacac gaaaccgcca ttcaacctgg
     8101 tgatctccaa cgtgccgggg ccgcgcaagc agatgtactg gaacggcgcg tcgctcgacg
     8161 gcatctaccc ggcgtccgtg ctgctcgacg ggcaggcgct gaacatcacg ctgaccagca
     8221 acggggacaa cctggacttc ggcgtcaccg gctgtcgccg gagcgtcccg catctgcagc
     8281 gcatcctgac ccacctggac accgcgctcg ccgaactgga acacgctgtg tctatcgggc
     8341 gcagctgacg agaacatttt gcagggcgcc aggacacttg aacgtcacgt tctcgtgcag
     8401 gcgccctgca aaatgttctc gtgggcctcc ggcccaaaag agggctgcgc cggtgaagtc
     8461 tccgtcgggc gcagagcgcc cttggggaga cccttgagcg ttagctgccg tcggagacgt
     8521 agatggcgcc aggggtgatc gtgtacagct gcccgtccgg gccggcggtc gcgtcgcgcg
     8581 tacggccgag gttggtccag agcttgtcgc cgttgccgtt caggtccagc ttgaacgtgc
     8641 cgcccttgag cgaggccatg tacagcgagc ccttgtacgc cgccagcccg ctcggcgtcg
     8701 ccaccgccgt cggccacgcc ttgaccgggt tggtcatccc cgccgtgtcg cacgggcctt
     8761 cgcaggtcgg ccagccgtag ttcttgccgg gctcgacctt gttcagctcg tcgagcttgt
     8821 tcgcgccgat gtcggagacg tacagctgcc cgttcaccca ggtcaggccc tggacgttgc
     8881 ggtggccgta ggagtagaca cggctgttga acgggttgcc cggcgcgggc gcgccgtcgg
     8941 tggtgacgcg caggaccttg ccgccgagtg agttcttgtt ctgcgcgttg gcgccgttct
     9001 gaccgtcgcc ggtacccgcg tagaggtagc cgtcagggcc gaacctgatc cgcccgccgt
     9061 ggtggaaatt cgcgccacga gggatgccgg tgacgatcgg cttcggcgtc tggcccagct
     9121 tcagcttggc gatccggttg tcggaactgg tcgtgtagta gatgaagacc gtctggtcgg
     9181 tggcgtattt cggcgagacg gcgatgccga gcaggccggc ctccggggtg acgctcaccc
     9241 ctgcgatggt ctggaccgtg gtgaccttgc ccgccttgtc gatcttgctg atcgtcttgg
     9301 cgtccttctg cgtgaagaga ccggtgccgt cgggcaggaa atcgatcgac caggcctggt
     9361 tgaggccgct cgcgatctgt ttgatcgcct ggacggacgg cgcttcggtg gcggccgccg
     9421 gaacggccgc gatcgaaacg gccgtcgccg cggcgaacgt ggtggcgaga gtacgacgta
     9481 aggacatggg acgcctcctt cagctacacc cctggagctc ggatggcggc gataggcggg
     9541 tggtcggggt acacccgtcg agttggatac aaacacacga aataacgaaa cggacaccac
     9601 tggacgggct atcgcagacg accccccacg accgccatat gcgcccagcg tgacgatcgg
     9661 ggcagctcga tcggccatag gtaggaaact ttacaaaatg ccacgggaac ctggctttac
     9721 atctggccag aatcggcggt ccgcttctag ggtgacggtg ctcgtcccgg ttcgttccca
     9781 tgtggacgtt aggagcagaa atgatcgaaa ccatcgaggt ctggaccacg cccgacttcg
     9841 tcgagtatga aactcccatg gaggtcaccg cttacgcggc ccgtatggag gactgatttc
     9901 gcatccggtg gtgggggccg tccccccacc accgtgccgc cgtcccgatc agcgagccgc
     9961 cggaggcagc accgtgcccc tttccccttc cgccgaaccg atgtcctcgt cggaattcgt
    10021 cgcggccctg cgtggacttt cccaccgcta ttggggtact catccgttcc atcggcggat
    10081 gcacgacggc ggactgtccg agtacgaact gaagatctgg gccgcgaacc gctggtacta
    10141 ccagtgtgtg ctcccgcaga aggacgccgc gatcatcagc aactgcccgg tgccggaaat
    10201 ccgccgggaa tggctcgacc gcatcgtcta tcacgacggg gcgaaggccg gggacggcgg
    10261 aatcgagcgg tggctccgct tgtgcgccgc ggtcggcctc gaccgcgaag aggttctcga
    10321 tcagcggcac gtcgcccccg gtgtacggtt cgccgtcgac gcctacgtga atttcgcccg
    10381 cacgagacct tggctcgaag cggtcgcttc ggggctgacc gaaatgttcg ccggccatct
    10441 catgcagcgg cgggtcgccg acatgctggc gaactactcg tggatcgcgc gggaagacct
    10501 cgactacttc accaatcgca tcgacaaggt ctccggcgag ggcaagggga cgctcgacat
    10561 cgtcgtacgg cacgccgtca cccgcgaaca gcaggagaag gcgatcgccg cgctgtcgtt
    10621 caagaccgac gtgctctggt ccatgctcga cgccatcgag cgcgccgcgg ccaaggagta
    10681 acgatgacca ccctcgagat gggctcggtg ccgcggctgc ggcgcggagt ccggctgagc
    10741 tatgaccaga ccagggaaac gcacgtcctc ctgttccccg aaggcgtgct cgtcccgaat
    10801 ccgaccgccg cggccgtgct cacgctctgc gacggtgtcg aagacgtcgc ggcgatcgct
    10861 tcggccttgc gcaagcgcta cgccggtgtg cgcgaggaag aaatcctgga tgtcctgtcc
    10921 cggctgggag atcggcggat cgtcgaatgg acctgaacac ctccaccgcg gcgccgccgt
    10981 tgggcatgct ggccgaactg acccatcgct gcccgctgca ctgcccgtac tgctcgaacc
    11041 cggtcgagct gatcgcccgc gacggcgaac tgtccacaaa ggaatggctg tccgtgctca
    11101 cccaggcacg ggagctcggc gtgcttcagg tacacatgtc cggcggcgaa ccgctcgccc
    11161 ggccggatct gcccatcctg gtcgagcacg ccacgaaact gggttgctac gtcaacctgg
    11221 tgacgtccgg gctcgggctg acggagtcca gattggacga tctcgccgaa cggggcatcg
    11281 cgcacatcca gctgtccgtc cagggcgcga ccgcggagcg cgcggaccgg ctcgccggtg
    11341 cacgggccca cgacaggaag ctggtcgtcg ccggactgat caagaaggca ggcctgccgc
    11401 tttcggtgaa tgtcgtgctg caccggcaga accacgacca gctcgccggg atcatcgacc
    11461 tggccgagaa gatgggcgcg gaccggctcg aactggcgaa cacgcagtac tacggctggg
    11521 cactgcggaa ccgcgacgcc ttgatgccga ccaggaggca actcgacgag gccgagccga
    11581 tcgtgcgggc ggccaccgaa cggctgcgcg gccgcatgga gatcatctac gtcgtcgccg
    11641 actactacga gcagtacccg aaaccgtgca tgtacggctg gggcgcgcgg caactgaccg
    11701 tggcgcccga cgggaacgtg ctgccgtgcc ccgcgtcgac ggcgatcgag acgctggaat
    11761 tcgacaacat ccgggacaag ccgctggcgc ggatctggta cgagtccagt tccttcaacg
    11821 cctatcgcag cgaggactgg atgtcggaca cctgcggcac ctgtgaaagg cgcgcgatcg
    11881 acttcggcgg ctgccggtgt caggcgttcc agctcaccgg tgacgcctcg gcgacggacc
    11941 cggtgtgctc acgttcgccg gatcgcggca tcgtcgatct catcctcgcc acacccccga
    12001 aagcggacga gctcgtgatg cggggaccgc gatgagggtg atcctgctcg gcaccgcggc
    12061 gggcggcgga ttcccgcaat ggaactgcgc ctgcgcgctc tgcgtttcgg acgcgccgcc
    12121 gcggacgcag gactgtgtcg cggtgagcgc ggatggcaag ggctggtacc tgctcaacgc
    12181 gtcaccggac atccgcgcgc agatcctcgc cacacccgcg ctgcgggcgg gaccggggcc
    12241 gcgggagatc ccgctgcgcg gggtgctgct caccgatgcc gagctcgatc attcgctcgg
    12301 cctgcttctg ctgcgggaag cgggcgggct tccggtgtgg gcgccggacg ccgttctggg
    12361 tgcactgtcc gagcagttcc ccgcacggtc gatcatcgac ggctacggcg gctgggactg
    12421 gctgccgtcg tcggaggtct ccatcgacgg gctccgggtg agcgcgcttc ccgtgagtga
    12481 caagcggccg aagtacgcgc gctcgtccgc tgaggacggt ccatgggtgg tggcgtaccg
    12541 gatcgaagac gtcgagaccg gcggtgttct cgtctacgcg ccttgtctga agagctggcc
    12601 ggacggattc gacgacttca ctcgcgatgc cggactagtg ttgctggacg ggaccttcta
    12661 cgcgccggac gagatgtcgg gcgccaccgc gaccaaggtc ggcgacggtg cccagctggc
    12721 catgggacat ttgccgatca ccggcagcct cgcgaagctc cggcccggcc cgcgttgggc
    12781 gtacacccac ctgaacaaca cgaatccggt ggtcgatccg tcttcgccgg agcacgccgc
    12841 cgtactggac ggcggcgcct cacttccctt ggatggcagc gaattcaagc tctaggcgat
    12901 gccttcggga ctcgcgcccg cgacggggac ggcgtctgcg gtgaggcggt cgatctccgc
    12961 gagctcgtcc gcggacaggt cgatatcggc ggcggcgaga ctggcttcga tgttggccgc
    13021 cttgcgcgcg cccacgatcg cgacgtgcac acccggccgg gcgagcgtcc aggcgatcgc
    13081 gagctggctg accgagattc ccttgtccgc ggcgaattcc ttgagcctgt cgacgatggc
    13141 gaggttgcgc cggaaggtct cgccggtgaa cgccgaagac tgcgaacgcc agtcggcctt
    13201 ctcgaacgtc gtctccgctg tgagggaccc ggtcagcagg ccgctgccca gcgggctgta
    13261 cacgagcacg ccaatgtcgt tctcccgcgc atacggcagc gggtcgatct cgatgtcacg
    13321 gcggaacagg tgatacggcg gctggagggt ttccaccgga cgggtcttgt cgaagtcggc
    13381 cagcgccgcg gcgtcgtagt tcgagacacc gatgtgccgg atcttcccgg cgtcgacgaa
    13441 ctcctggagg atgcccgcgg tctcctccgc gggcgtgccg ggatcgggcc agtggatctg
    13501 gtagaggtcg atgtggtcga cgtcgaggaa gcggaggctg tcctcaatcc cctgcgtcag
    13561 ccattcgcgg cgggagtcac gcgggcgctc ggaacgcggc ttggtgccgc ctttcgttgc
    13621 aatgacgagg ttgtcgcggt cgcgcttgag ttcctcgcgc aacgccttcc cgagcagcgc
    13681 ttcggatttc ccgaaaccgt aggcctgagc ggtgtcgaag aaggtggccc cgagttcgcg
    13741 ggcgtggtgg atcgcggcga tcgccgagtc ctcgtcgaac gaaccccagc ccccgccgag
    13801 ctgccaggtg ccgaaggcga tcctcgacac ctcgaggccg ctcctgccca atgtcgtcgt
    13861 acgcatacct ctcagcagag cacagacatc ggatcattgc accggatctc ccggccaacg
    13921 aaacccccaa ataactgttt gacggttgtc gtcccggcag tcgatactcg gccgcatgtc
    13981 cgagtccccc gccctcgacg gattgcgcgt cctcgcccat cccatccggt tgcgcgttct
    14041 gtcgcttttg accggtgtcg cgatgagcgc ggccgaggtc gcccgcgaac tcggtgagac
    14101 acaagcgaat gtcagctatc acctgcgacg gctgcacgag gcaggactgc tcgacatcgt
    14161 cgaagaggtg cggatccggg gcgggctggc gaaacgctac cggcacgatc cggagtcggg
    14221 atcgtggttc acgtcgacga atccgcacga ggaacagctg ctcctcgcga cgatggccga
    14281 agagctcaag cggcgcggcg agttccgcgt ccccggtcaa cggggttcga cgaccgacac
    14341 ggagatctgg gtcgatcgcg agacctggga gaaggcgctc gagcaagctc gtgaactggg
    14401 cgagcttctg cactcggccg cgaagccacc ccgcacccgt ggcacgatcc cggtcagcgc
    14461 gacggtttcg atgttcgaaa tgaggcgacg gtgacctcgc tgcgagaacc cctgcgtcac
    14521 cataacttcc gctggctggt cggcggccgc acgttcgggg agttcggcaa cgccgtcgcc
    14581 ccgctcgcgc tggcgttcgc ggtgatcgac ctgaccggtt cggcggtgga catcggcatc
    14641 gtcgtcggcg cccgttcggt ggcgagcgtg gtcctgctgc tgttcggcgg ggtactggcg
    14701 gaccggctgc cccggtcggt gatcctgcag ggcaccgagc tcgccgccac gttgacccag
    14761 gcggtcatcg cggcgagtgt cctttgcgga ttcgcgtcga tcccgctgct ggtcggcctg
    14821 agcgtggtca acggcgccgt cgccgcgatc tccgcgcccg cttcggcttc gctcaccccg
    14881 ttgacggtgc ccgccaccct gctggcgcag gccaacgcac tgggcaggct gctctcgaac
    14941 tccggcagga tcgccggcgc cggactcggc ggcatcctgg tcaccgcggt cggccccggc
    15001 tgggcactcg gcgggaacgc gctgctgttc ctgggctccg ccctgtccta ccggcgtatc
    15061 cggctcagcc gccgcgaacg gctccccggc agccgcccgc tggcggaact cgctgaaggc
    15121 tggcgcgagt tccggtcacg gacctgggtg tgggtcgtgg tcgtgcagtt catggtggtg
    15181 aacgccgtca tcgcgggcgg gatcgcggta ctcggccccg tcgtcgccga cagcagtttc
    15241 ggccgctccg gctggggatt cgccctcgcc gcgcagacga tcggctcgct cgtcggcggg
    15301 atcctcgttg cccgctggca gccgcggcgc gcgctgttcg tcggggtcgc ggtgatcctt
    15361 ttcgaagcgc cgccgttgat cctcctcggc caggcgccgt ggctgccgct gctgctggcg
    15421 gccatgttcg tctccggcct ggcgatcgag cagttcgtgg tggcctggga cgtctcgctg
    15481 caggagaacg tgcccgagga caaactcgcg cgcgtctatt cctacgacat gctcggttcc
    15541 ttcatcgccc ttcccctcgg ccagatggcg gccgggccgg ccgcgcagca cttcggggtc
    15601 agcacgaccc tgctcgcttg cgccgcgctg gtcgtggccg ccacctgtct cgccctgtgc
    15661 agcggacagg tgcggggcct tgtccggaaa acccacgcca cccacccctg accgccaggc
    15721 gatagcaaag gtcccttgct ctctttccgc tggtcacggc cagggacgga cctcttcgag
    15781 gagcttcgcg accgcgagga cgaggtcatc ggagtgccgc gggccgacga tctgcagacc
    15841 gaccgggagc ccgctggagg tgcggcctgc cgggacgctg atggcgggct gctgggtcat
    15901 gttgaacggg taggtgaacg gcgtccagtc cggccagccg ctcagcccgc tgcccggcgg
    15961 cacctcgtgc ccggcctcga aggcggcgat cggcagggtc ggcgtgatca gcacgtcgta
    16021 acgcgtgtgg aactcaccca tcaggatgcc cagcgcggcc cgttcggcgt tggcgccgag
    16081 gtagtcgctc gccgagaagg tcttgccgga ctcccacacc ttccgcagtc ccggatcgac
    16141 cttggtctcc gaaccggcgg ggaaagtgtc cagccacttg gccgcccccg tcgaccacag
    16201 gatgtcgaag gccggctttg gatcggtgaa gccggggtcg gtctcttcga tgtacaggcc
    16261 cgcatcgccc agcgactgga cggccgactt gacgatcgcc gcgacctccg ggtcgacatc
    16321 gacgtagccg agcgtcggcg agtaggcggc gttcagcccg cgtacgtccc ggcggacggc
    16381 ttcgcggaag gtcgacaccg gcggggcgag cgccgccggg tcccggtagt cgggcatggc
    16441 gaggacgtcg agaagcagcg ctgtgtcgtc caccgaacgc gccatcggcc cggcgtgcga
    16501 gagcggcccg aacgggctcg ccgggaacag cgggatccgg ccgtgtgtcg gtttgagacc
    16561 gacgattcca cagaacgaag ccggaatccg gatcgagccc ccgccatcgg tgccgacgga
    16621 cagttcgccc atccccgccg cgacggccgc ggcgcttccc ccgctggacc cgcctgccgt
    16681 cgtcgacagg tcgtgcgggt tgcgggtgat cccggtcagc gtgttgtcgg tgacgccctt
    16741 ccacgcgagt tccggtgtcg tggtctttcc cagcagtacc aagccgttct cacgcagcct
    16801 ggcggtgacc gggctgtcga cgtcccacgg ctgatcgggg tcgatgcacc gcgaaccacg
    16861 cagcgtcggc cagccctgcg tcaggaacat gtccttgatc gaagccggga caccgtcgag
    16921 ccagccgatc ggattaccgt cccgccaacg gacctcggaa gccttcgcct gttcgatcgc
    16981 gccttcggcg tcgacaaggc aataggcgtt gatctcgtcg tctcgttctt cgatgacacg
    17041 caacgcgttc tgggtggcct cgaccggcga cagctctccg gtggcatacg cggcgacgag
    17101 ctcgctagcg gtcaacttga tgtcgttcat ccggccccta accttggcga agcgtctccg
    17161 acggcacgta tccgagctgc ttgtccacga cgttgcgcag cggctccccc gcacgccagc
    17221 gacggaagtt gtccgcgaac acctctacca gagtattacg ccagccgacg aagtcgcccg
    17281 acatatgcgg cgagatcagc acgttctcca tagtccacaa aggactttcg ggtggcagcg
    17341 gctcggtgtc gaagacgtcg agcgccgcgc ccccgagcga cccgtcccgc agtgcgccga
    17401 ccaagtccga agtgaccacc agttcgccac ggccgacgtt gacgaaccgc gcgccgggct
    17461 tcatcgcggc gaaggcctcg gcatcgaaca tgcccttcgt ctgctcggtc agcggtgcga
    17521 ccgcgacgac gtagtccgcc tcgggaaggt gactgcccaa gtccgaagag gcgtacaccg
    17581 ctccgaagtc gggatcgccc tcacgaggac ggcgtccgac acccgccacc gacatcccgg
    17641 ccgcccgcag catcctcgcg atcgaccggc cgatcggccc ggtgcccacc acgaggaccc
    17701 gcctgcccga gatccgttcg ctctcccggt gcttccaccg cttctgtcgc tgcaggtccc
    17761 acgaacgggc gaaatccttg gcgaacgcga ggacgacccc gaggacgtac tcggctatcg
    17821 ccccgtcgaa cacgccacgc gagttcgtga gcacgacgtc actctgctgc acccctggga
    17881 agagcactgg gtcgacgccc gcgctggcga tgtgcagcca gcgcagccgg tcggccgcgt
    17941 gccaggcacc aggaacggcg gtcgagagga agtcgtagac gaagaacgcg tccgctccgg
    18001 ataacgcgtc ggccaagccc gcctcgtcgg tgtaacgaac caccgcttca gcttcgatag
    18061 cgcgcatgtc cggtgggcgc gtgtctccgc agagcacggc cagcaccggg gtctccgaag
    18121 cgatcacgtt gacaccgtaa aagtggctcg tatgattgtc aacaatccga ggaacgaccc
    18181 cggagcaccg gacctgtggc agcagaagct ttccggaggc tgagacttgg atttcgactt
    18241 actggagttc gaaggccctt tggcgcagcg cggtatcggc gtgatcgctc ccttcgacct
    18301 tgccctggaa cgtgagctgt ggcgctgggt gcccatggag gtctccctcc atctggctcg
    18361 gacgccgtac gagccagtgc ccgtcagcat ggagatggcc cagctcgtca gcgacagcag
    18421 gcatctcgcc accgccacga gagatgtgct ccacgtggag cccgaagtgg tcgcctacct
    18481 ctgcacctcc ggaagtttcg tcaacggtgt ggactacgaa cgctctctga ccaaggcgat
    18541 ctgcgacgcg ggcgcgccgg acgccgtcac cacctccggc gctcttgccg aggtcctgca
    18601 ccagctcgac ctccaccagg tctcggtgct gacgccctac gacggcgacc tgaccgggaa
    18661 gctgcacgac ttcctggccg aactcggcgt gcgcacagtc tcgagcgacc acctcggcct
    18721 cggcggtggc atctggaagg tcagctaccg gaccatcgcc gaacgcatcc tcgccgccga
    18781 ccacgccgac gccgacgcta tcttcgtcag ttgcaccaac ctccccactt acgatctgat
    18841 cgagccgctc gaaagcgcgc tcggcaaacc cgtcctcacc gcgaaccagc tcacgatgtg
    18901 ggcctgcctc cggcggatga acctgccgat cgtcgggccc ggcaagtggc tccgggaggt
    18961 cgactgacct cttcccttac gattgtcgac aatctgtcct ccggaggtcc cgtgcccatc
    19021 agcccgctca ccccacccga accgccgtcc gagacgacca cgatcggttt catctacccc
    19081 gatcacgcgg ccgaagacga ctacccgctc gcggagcagc tcctcggcgg cgacatggcg
    19141 gggatcaagc tgccggtcga gcacatctac gggaccgatc tgcacgccgt acccgaactc
    19201 ctggacctcg gcagcgaaag ccgcctcgcc gacggtgccg cgctgctggc caagcacgaa
    19261 ccggacgcgg tgatgtgggc ctgcaccagc ggcagcttcg tctacggctg ggaaggcgcc
    19321 cgcgaccagg ccgaccggct ggccgccgtc gccggcgtcc cggcgtcgag cacctccttc
    19381 gccttcgtcc acgcggccca cgccctccgc gtccggcggg tcgcggtcgc cgccagctac
    19441 ccggacgacg tcgcccggct gttcgtcgag ttcctcggcg cgggcgggat cgaagtggtc
    19501 tcgatgggca gtgcggacat cgacaccgcc gccgaagtcg gcgaactcag cccggaagcc
    19561 gtcgtcgagc tcgcggcgag cggcgatcac ccggccgccg acgcgctgct cgtccccgac
    19621 accgccatgc ggacgctcgg cgagatcaac acgctcgaga ccagactcgg caaaccggtg
    19681 ctgaccgcca accaggtcac cgtctgggag ggcctgcggc tcaccgggag gtctccgctc
    19741 gtccggacgc tgggcgcgct gttcgggcag aggggcaact gaaccatgtc cttgccggat
    19801 atcgagccgg tcagccggga atcgaccgcc gggatcatcg cgcgccagtt gcgggacgcg
    19861 atcatgaccg gcgcgcttcc tcctggcacc cagctcggtg aaacggatct ggcctcccgg
    19921 ttccaggttt cgcggggacc tctgcgagag gcgatgcagc acctcgtttc cgaagggctc
    19981 ctgcgcagcg agcgccaccg cgggttgttc gtgatcgacc tcgaacccgg cgacgtctac
    20041 gacatctact cggcgcgctc ggccatcgag cgcgccgcga tgctgcgagc actgcgcggc
    20101 gaccgggaac gggtggccac cgaactcgaa caggccgtga ccgccatggc caccgccgcg
    20161 gacgacgacg atccgaccgc gctctcctgg gcggacctcc gcttccacga ggcgctgatc
    20221 gccgcttccg gcagcaaacg gctcgtgcgg atggcccgga ccctgctgat cgagaccagg
    20281 atgtgcctca ccgcactgca ggggacctac cagcgggtcg aagaacgggt caccgaacac
    20341 accaggatca tcgaggccct gcgggccggt gacgaagaaa ccgcgctgtc gctgctggaa
    20401 gcccatatgg aggacgcggt ccagcgactg gcccctggaa ccagcctgcg agagggcgaa
    20461 gctcccgccg tgccttaggg attcagccac ggtgccgcgc ccccagcacc ggctgcccgc
    20521 ccgtgccgcc gcggaactcc ctttcccacg gccaattgcc gtgctcgtcc tcgtaaacca
    20581 gttgcagggc gcggaactct tcgccgtaca tgaggacggc ggtgaccagg tgagccgacg
    20641 gcgaactgag cgggacgacc tcgaacgcgg gccatcccac cgcggcgggc agcacctcac
    20701 ccgattcagg cggccccgac cggaccactt gctgggcgaa atagttcagc agctgactgg
    20761 atcttcgctc tctgaggccg gtgacgacga gttccggcag ccctgcgtcg gtgagcccga
    20821 cggtgtacgc gaagctgggt tgagcgcctc cgctatcgac cgcctgcacc atccagccgt
    20881 acttccggat cagcggacgg acttcctcga tgaggtagtc gttgcgggtc ttcccagggt
    20941 tgtcgcaatg ccagcacatc ggcactcctc cagtagtcga attcgatgat cgacactgtg
    21001 caccggggca ccgacaagaa ctcacgggcc aggcacgcgg aggcgatgac ggcgcccttt
    21061 catcgcgagt ttttcccttt catcgcaacg ttttacactt ttctccgaaa aattcgggca
    21121 ggtcgtgacc gggcgaacgc gcagcccgca tttcccgtcc acacccagaa cgcccatctc
    21181 ggcgtaagta cgcgaaggcc ccttccttgc tcctgatgca aggaaggggc cttcacgcac
    21241 ttacacgcca ccccgaattc atgaatggac cgttcatgac ttcgcgggac ttgacaagcc
    21301 actatgcgga tggttcaaga tagagcggcg accaccgcgg acccgagttc ggcggtggtg
    21361 gacttcccgc cgagatcagg ggtctgcacg gccccctccc cgagaacctt ttccaccgca
    21421 gcgtgaacat cttgtgccgc aacggtttca ccgagatggt cgagcagcat cgcccccgcc
    21481 aggatctgcg ccaccggatt cgcgatgccc tgtccggcga tgtcgggagc gctgccgtgc
    21541 acagcctcga acatggaagg gaactcacct gttggattga tgttgcccga aggcgccatt
    21601 ccgagcccgc ccgtcacggc cgccgccagg tcgctcagga tgtcgccgaa gagattggaa
    21661 ccgaccacga cgtcgagccg gtccggcgcc tgcaccatcc gcgcggcgag cgcgtcgaca
    21721 tggcactgtt cggcgtgcac gtccggatac tccgaagaga tctcggcgaa gatctcgtcc
    21781 cagaacggca tcgagtgaat gagcccgttg gacttggtcg ccgagcagac ccgccccgtc
    21841 cgcgtcttcg ccagttcgaa ggcgtagcgg atgatccgct ccaccccgac ccgcgtgaac
    21901 acggattcct gtaagacgaa ctcgtttccc tggccacgat tgtgcctgcc accgatctcc
    21961 gagtactcgc cctcggagtt ctcccggacg atcaccatct ccagttcatc ggcactcctg
    22021 cccgacagtg ccgat
//
