LOCUS       NZ_KB907506            12794 bp    DNA     linear   CON 21-MAY-2024
DEFINITION  [Pseudomonas] hibiscicola ATCC 19867 G370DRAFT_scaffold00009.9,
            whole genome shotgun sequence.
ACCESSION   NZ_KB907506
VERSION     NZ_KB907506.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      [Pseudomonas] hibiscicola ATCC 19867
  ORGANISM  [Pseudomonas] hibiscicola ATCC 19867
            Bacteria; Pseudomonadota; Gammaproteobacteria; Lysobacterales;
            Lysobacteraceae; Stenotrophomonas; Stenotrophomonas maltophilia
            group.
REFERENCE   1  (bases 1 to 108986)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name :: Stenotrophomonas maltophilia ATCC 19867
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: ATCC 19867
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R37654
            finishing_strategy                :: Missing
            environment                       :: Host
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi15375
            Type Strain                       :: No
            Funding Program                   :: DOE-CSP 2012
            Isolation Site                    :: Plant
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R37654
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000382065.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 01:07:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,084
            CDSs (total)                      :: 4,007
            Genes (coding)                    :: 3,964
            CDSs (with protein)               :: 3,964
            Genes (RNA)                       :: 77
            rRNAs                             :: 5, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 65
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 43
            CDSs (without protein)            :: 43
            Pseudo Genes (ambiguous residues) :: 0 of 43
            Pseudo Genes (frameshifted)       :: 15 of 43
            Pseudo Genes (incomplete)         :: 31 of 43
            Pseudo Genes (internal stop)      :: 7 of 43
            Pseudo Genes (multiple problems)  :: 7 of 43
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:56:28
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 12794
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB907506.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 408460
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..12794
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..12794
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12794
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[1915:2794](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1916..2794
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            343..1629
                     /db_xref="GeneID:90527545"
                     /gene="tilS"
                     /locus_tag="G370_RS0119560"
     CDS             343..1629
                     /EC_number="6.3.4.19"
                     /GO_function="GO:0016879 - ligase activity, forming
                     carbon-nitrogen bonds [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527545"
                     /gene="tilS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005418067.1"
                     /locus_tag="G370_RS0119560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA lysidine(34) synthetase TilS"
                     /protein_id="WP_026347278.1"
                     /transl_table=11
                     /translation="MTAFPALVPLDAPLLVGYSGGADSTVLLHWLWRCAQPTGTALRAV
                     HVHHGLQPDADAWALHCRQQCAALGIQLAVHRVQVDNRAGLGLEGAARQARRAAFAAEL
                     REGETLALAQHQDDQAETFLLRALRGSGVDGLAAMSAHSHLGEHPLWRPLLSTSRDALL
                     HYARQHALQWIEDPSNAEDHADRNFLRLQVLPLLRQRWPHAASALAGSATHCRQTRELL
                     DEEDAELIAHLEVAPRVLSLELLRQVSPGRAARVLRAWVLGHAAAPLPATVLKQALDEL
                     LPAGNDRQARVRWHDHAIQQWRDHAYLLPARLPALPPAWQAEWDGRAPLALPNGGQLRL
                     QGAPAFERPLQVRARAGGERILLPGRQHSHALKDCLQRERLAPWRRAQLPLIFDGPQLL
                     AAADVVIAAPLQAWLQANGAQLRWRPGGW"
     gene            1666..1926
                     /db_xref="GeneID:90527546"
                     /locus_tag="G370_RS0119570"
     CDS             1666..1926
                     /EC_number="3.1.11.6"
                     /GO_component="GO:0009318 - exodeoxyribonuclease VII
                     complex [Evidence IEA]"
                     /GO_function="GO:0008855 - exodeoxyribonuclease VII
                     activity [Evidence IEA]"
                     /GO_process="GO:0006308 - DNA catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527546"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005410522.1"
                     /locus_tag="G370_RS0119570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="exodeoxyribonuclease VII small subunit"
                     /protein_id="WP_005410522.1"
                     /transl_table=11
                     /translation="MAKKSPENASPVAQFEQSLESLEQLVEQMETGELSLEASLSAYER
                     GVGLYRQCQQALEQAELRVRLLSDPAQPEASEPFDPPSHDG"
     gene            1916..2794
                     /db_xref="GeneID:90527547"
                     /locus_tag="G370_RS0119575"
     CDS             1916..2794
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527547"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008264747.1"
                     /locus_tag="G370_RS0119575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_019662099.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.2e-67, bitscore:
                     219.8, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEVLFARWRDRIESQLDAALPSPAEAPQRLHQAMRYSVLGGGK
                     RMRPLLVYASGHLFGAQPEQLDAAAMAVELIHAYSLVHDDLPAMDDDALRRGKPTTHIA
                     FDEATAILAGDALQTRAFGLLADAPLTATLRVACLQTLAHASGASGMCGGQALDIDATG
                     QQQTLAALTRMHALKTGALIRAAVRMGALCGQAHEPQLAQLDSFADALGLAFQVRDDIL
                     DVEASSEQLGKTAGKDEAQEKSTFPALLGMDGAKAQLRELAARMQATLAGHGEEADPLR
                     ALATLAVERNH"
     gene            complement(2906..3277)
                     /db_xref="GeneID:90527548"
                     /locus_tag="G370_RS0119580"
     CDS             complement(2906..3277)
                     /codon_start=1
                     /db_xref="GeneID:90527548"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014647933.1"
                     /locus_tag="G370_RS0119580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_019662100.1"
                     /transl_table=11
                     /translation="MSEFDNVPPPPATTEAPADQRTMALAAHLLGIFTGFIGALIIWLI
                     NKDDAGKAFVTDQAKEALNFQITVAIAMVICMILTIVVIGAILMPIVGLVSLVFCIIAA
                     VKANNGEAYRYPFALRLIK"
     gene            complement(3365..4732)
                     /db_xref="GeneID:90527549"
                     /gene="pmbA"
                     /locus_tag="G370_RS0119585"
     CDS             complement(3365..4732)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527549"
                     /gene="pmbA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019662101.1"
                     /locus_tag="G370_RS0119585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloprotease PmbA"
                     /protein_id="WP_019662101.1"
                     /transl_table=11
                     /translation="MNVIAPEVAVGDDSAARLERLADLSQQLLDRARALGASQAEVSCS
                     EDRGLEVNVRLGEVETVQSTRDRGIAVTVYFGQRKGSASTGDLNEASLAATVEQACAIA
                     RHTEDDPAAGLAEAALMATDFPDLDAWHPWALQADEAVDLALACENAGREADAQIRNSD
                     GASVSSMQSLSVYANSHGFIGRERGTHHSVGCALIAGQGDGMQRDGWYTSALAREDLEE
                     VGLVGRRAAERTVARLQPRSMATGSMPVLFAPEVARSLVGHLLSAVSGGALYRQASFLL
                     DSVGLQLFPGWMQIEELPHLRRGLRSAAFDGDGVATRASALVRDGVLQRYVLGSYSARK
                     LGLQTTANAGGVHNLQLAANAGALQDIARQMGNGLLVTELMGQGVNGVTGDYSRGAGGF
                     RVENGEIQYPVDGITIAGNLREMFSSIEAVGSDVDPRSHIRTGSILVGRMTIAGND"
     misc_feature    4776..4789
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.72"
                     /tool="antismash"
     gene            4800..5390
                     /db_xref="GeneID:90527550"
                     /gene="yjgA"
                     /locus_tag="G370_RS0119590"
     CDS             4800..5390
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527550"
                     /gene="yjgA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019338623.1"
                     /locus_tag="G370_RS0119590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribosome biogenesis factor YjgA"
                     /protein_id="WP_019662102.1"
                     /transl_table=11
                     /translation="MRGRDEETGEFHDKSRSQNRRDALDVLALGEKLVSLTPAQLARLP
                     IPEDLLPHIAECKRITAHIAHKRQLAFLAKHMRREEEATLDAIRDALDANSETGRREVA
                     MMHRVEDWRDRLLAEGDKALAALLDDYPQADRQQLRTLVRNAQAEKARNKPPRAYREIF
                     QVLRGLMLPAALGLKTAGDEDAGHVETDEADED"
     gene            complement(5432..6877)
                     /db_xref="GeneID:90527551"
                     /gene="tldD"
                     /locus_tag="G370_RS0119595"
     CDS             complement(5432..6877)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527551"
                     /gene="tldD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007972594.1"
                     /locus_tag="G370_RS0119595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloprotease TldD"
                     /protein_id="WP_019662103.1"
                     /transl_table=11
                     /translation="MTDIALTLAQDRLLRPGGLDTAGLERTFGQLLGPGVDFGDLYFQH
                     ARRESWSVEDGIVKDGAHSIEQGVGVRAISGEKTGFAYSDDIHADALLAAAQSARAISR
                     EGGAQSGRSLLRGNARALYPALDPIDGIGNEAKVEVLKRLDGYLRAADPRVKQVMVSLS
                     GGVDTVLIARSDGVLGADVRPLVRLNVQVIVEHHGRRESGYAGGGGRYGYEELFADGRP
                     EAFAREALRQALVNLDAVPAPAGVMPVVLGPGWPGVLLHEAVGHGLEGDFNRKGTSVYA
                     GRIGERVAAPGVTIVDDGTLDGRRGSLNIDDEGHPSQCTTLIEDGILVGYMQDSLNARL
                     MGVAPTGNGRRESFAHMTMPRMTNTYMRAGQHDPQEMIRSVKKGLYAVNFGGGQVDITS
                     GKYVFSATEAYLIEDGRVTTPVKGATLIGNGPETMQKVRMVGNDLALDEGVGVCGKDGQ
                     SVPVGVGQPSLLIEGITVGGTQA"
     misc_feature    6873..6887
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    6880..6894
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.56"
                     /tool="antismash"
     gene            complement(6938..10792)
                     /db_xref="GeneID:90527552"
                     /locus_tag="G370_RS0119600"
     CDS             complement(6938..10792)
                     /codon_start=1
                     /db_xref="GeneID:90527552"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014647937.1"
                     /locus_tag="G370_RS0119600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YhdP family protein"
                     /protein_id="WP_019662104.1"
                     /transl_table=11
                     /translation="MSAPPRLRLRRIRRHLIAACAVGLVGLALLVGTLSQLLPLAERHP
                     DRIAAWLSERAGQPVRFDQLQTAWTRRGPLLQLKGLHIGAGRGLAIGEAEVLVSMYSGL
                     LPGRSLTELRLRGLALDLQQDASGRWSVRGLPQSADGGDPLDALRRLGELQVIGGRLGV
                     HSPTLGIDTTLPRIDLRLRVNGDRLRVGVRAWAQAEALPLTAVLDVDRTRGNGEAWLGA
                     DPVDFHAWSPLLAAGGVRLREGKGELNLWLTLREFVPVAVTTDSDLRDVRIDGAPIPGM
                     AAPQLQLQRLQARLRWQRQAEGWALQVPRLRLKNEDGEQRLDGLQLQVGKQLRVRSGEV
                     QAGIALRALALSDRLEPGLRRWLFLSRPQLDVRALQLAGERDGPLWAQGELQSLGFASV
                     GNSPGLRGLGGRFEGDANGFSLQLQPQRQLQFDWPTGFGVRHDLQLAGQIVGWRDEGGG
                     WRIGTPAMRVEGTDYAADVRGGVWFQGDGTRPWLQLAAKLDDVPMTAAKRFWIHSKMSK
                     GATDWLDMALAGGQVRGGVGLVTGDLDDWPFDNNDGRFEATGHITNGDIRFQHDWPLMS
                     QVDADIAFIGPGFDMHGRGDLAGVAVQKFEAGIQDFGQQPLYVRADAQSEAGRLLAMLR
                     QSPLHKDYGDTLDNLTAAGPAHVTFDLLQPLHHDKGGGHLQGTVDLAGVKLVDKRFQLA
                     FDNMHGQARYSNGGFDAEELSVRHLGQDGRLSLRAGGYVHDSRLAFESKLSATLDAGVL
                     IDRAPEMAWLKPYITGTSPWTIAVNLPKVAPGAPAPPSELRLSSDLVGTRLDLPAPLDK
                     PAAEPLATTVAAQLPMGAGRIDVAFGQRLALAARSHNNQTGVQVTLGSDHVDREPPPSG
                     LTVNGRSPTLDALEWIGLARGGSDDNTMPLRAVDVQVGQLKLIGGVFEQTRLQLHPGAQ
                     ALDVRLAGPSLAGRLTVPNADGGTISGQLDRVHWQSLPAAPDAPAAPARVQAGANDMDP
                     AKLPPFALDIADLKFGKVVLGQAVLRTRPLANGLNVDELRFRAPDQEIDISGRWLGRAG
                     GARTELTAQVRSEDLGGLMQNLDYGGQLRGGSGQAQLQATWSGGPSDFQLGNLQGRLDL
                     HARNGQLLELEPGAGRVLGLLSVTQLPRRLMFDFRDFFSKGFAFNQIDGSMQFGQGMAR
                     TDKVLIEGPAANITIRGQADLRNQQFDQTIDVNPRAGNLLTVVGAVAGGPVGAALGAAT
                     NAVLSKPLGEIGARTYKVTGPWKEPKVEVIERSRDKAPPPAPAPAPAIPPTVTGLPRPR
                     "
     gene            complement(10823..12310)
                     /db_xref="GeneID:90527553"
                     /gene="rng"
                     /locus_tag="G370_RS0119605"
     CDS             complement(10823..12310)
                     /EC_number="3.1.26.-"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0006396 - RNA processing [Evidence IEA]"
                     /codon_start=1
                     /db_xref="GeneID:90527553"
                     /gene="rng"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002802933.1"
                     /locus_tag="G370_RS0119605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribonuclease G"
                     /protein_id="WP_019662105.1"
                     /transl_table=11
                     /translation="MSEEILVNVTPRETRVAVIENGMLQELHIERGWRRGVVGNIYKGK
                     VQRVMPGMQAAFVEVGLERAAFLHANDVVRPAPVASADTENTTLPPPASVPIVELLRDG
                     QDIVVQVVKDPIGTKGARLTTQISIPSRYMVLLPQSKVVGVSARIEDEAERARLKALVT
                     ELSAQHGGYGYIVRTNAEGQPAEAIAEDIAYLSRVWNVVERRGREAPSCSIIYEDLSLP
                     LRSVRDLIRKDVDKVKVDSKETFGQLQAFVAKYMPVLAEKLELYSGDRPIFDMFGVEDE
                     IGRALDKQVPLKSGGYLVIDQTEAMTTIDVNTGSFLGQRNLEETVFRTNLEAAQAVARQ
                     LRLRNLGGIIIIDFIDMDDAEHRRQVLRTLEKALARDHAKTTVYDFSPLGLVEMTRKRT
                     VESLERQLSETCPQCSGRGSIKTTETVTYEIFREITRAVRQFDAARLLVIASTKVVARI
                     TDEESAAVAELEEFLGKSIRFQADEQYLQEQFDVVLL"
     misc_feature    12665..12681
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
ORIGIN
        1 gttggtaggt gtcgaccttg gtcgacacat ctgtcagata tcgaatgagt catccacgca
       61 tggcgtggat ctactgtgtc caccaaggtc gacacctacc aaagcggtgc aagacgccgt
      121 tccgacagat cgcggcaatc tgtcgaaggc ggggtgggtc cggttgcggg ggcgtgagcc
      181 gcatggatgc ggcgaccgag cttacatgga cgtacttgca gcgtcccccg caaccggacc
      241 caccccgcca tccctcagca gaccagctgt tgctgttgct ctggctcgta gcaggtgcag
      301 ggcgcagccc tgccaagcaa accccaccct atacttgccg ccgtgaccgc cttccctgcc
      361 ctcgttccgc tggatgcgcc gctgctggtg ggctacagcg gcggtgccga ctccaccgtg
      421 ctgctgcact ggctgtggcg ctgcgcccag cccaccggca cggcactgcg tgcggtgcac
      481 gtgcaccacg gcctgcaacc cgatgcggac gcctgggcgc tgcattgccg gcagcaatgc
      541 gccgcgctgg gcatccaact ggccgtgcat cgcgtgcagg tcgacaaccg tgcgggcctc
      601 ggccttgaag gcgcggcgcg gcaggcgcga cgcgccgcgt tcgcggccga gttgcgcgag
      661 ggcgaaacgc tggcacttgc gcagcaccag gacgaccagg ccgagacctt cctgctgcgc
      721 gcgctgcgcg gttcaggcgt cgacggcctt gcagcgatgt ctgcacacag ccatcttggc
      781 gaacatcccc tgtggcgacc actgctgtcg acgtcgcgcg acgcgctgct ccactacgcc
      841 cggcagcacg cgcttcaatg gattgaagac cccagcaacg cggaagacca cgccgatcgc
      901 aacttcctgc gcctgcaggt gttgccgttg ctgcgccagc gctggccgca cgcggcgtcg
      961 gcattggccg gcagcgcgac gcattgccgg cagacccgcg aactgctgga cgaggaagac
     1021 gccgagctga tcgcgcatct ggaagtggca ccgcgcgtgc tgtcattgga acttctgcgc
     1081 caagtgtcgc cgggccgcgc cgcacgcgtg ctgcgcgcct gggtgctggg ccatgctgca
     1141 gcaccgttgc cggccacggt gctgaaacag gcgctggacg aactgctgcc ggccggcaac
     1201 gatcgccagg cccgtgtgcg ctggcacgat cacgcgatcc agcaatggcg cgaccacgcc
     1261 tacctgctgc cagcccggct acctgcgctc ccccccgcgt ggcaggccga atgggacgga
     1321 cgcgcgccat tggcgctgcc caatggcgga caactgcgcc tgcagggcgc cccggccttc
     1381 gaacgcccat tgcaggtacg tgcgcgcgcg ggcggtgagc gcatcctgct acccggtcgc
     1441 cagcattcgc acgcgctgaa ggactgcctg caacgtgagc gtcttgcccc gtggcgccgc
     1501 gcgcagctgc cgttgatctt cgatggcccg cagttgctgg ccgccgccga cgtggtcatc
     1561 gccgcgcccc tgcaggcctg gttgcaggcg aacggggcac agctgcgttg gcgtcccggc
     1621 ggctggtgaa ttgacccccg cgcgcagccc gtccacactt gccgcatggc caagaagtcc
     1681 cccgaaaacg cctccccggt cgcccagttc gagcagtcgc ttgaatcgct ggaacagctg
     1741 gtggagcaga tggaaaccgg cgagctgagc ctggaagcct cgctcagtgc ttacgaacgt
     1801 ggcgtcggtc tgtatcgcca gtgccagcag gcgctggaac aggccgaact gcgcgtgcgc
     1861 ctgctcagcg atccggcgca gccggaagca tccgagccgt tcgatccgcc cagccatgac
     1921 ggctgaggtt ctgttcgcgc gctggcgcga ccgcatcgag agccagctcg acgccgccct
     1981 gccctcgccc gccgaggccc cgcaacggct gcaccaggcc atgcgctact cggtgctggg
     2041 tggcggcaag cgcatgcggc cgctgctggt gtacgccagt ggccacctgt tcggcgcgca
     2101 gccggaacag ctggacgcgg cggcgatggc cgtcgagctc atccacgcct attcgctggt
     2161 gcacgacgac ctgccggcca tggacgatga cgcgctgcgc cgcggcaagc cgaccaccca
     2221 catcgccttc gacgaagcta ccgccatcct cgccggtgac gccctgcaga cccgtgcctt
     2281 tggcctgctg gccgatgcgc cgctgacggc cacgctgcgc gtggcctgcc tgcagaccct
     2341 ggcccacgcc tccggtgcct ccggcatgtg cggcggccag gcgctggaca tcgatgccac
     2401 cggccagcaa cagaccctgg cggcactgac ccgcatgcat gcactgaaga ccggcgcact
     2461 gatccgcgcg gcggtgcgca tgggtgcgct gtgcggccag gcccacgaac cgcagctggc
     2521 ccagctcgac agtttcgccg atgcactcgg cctggccttc caggtccgcg atgacatcct
     2581 ggatgtggaa gccagttctg aacaactggg caagaccgcc ggcaaggacg aggcacagga
     2641 aaagagcacc ttcccggcgc tgctgggcat ggacggcgcc aaagcacagc tgcgcgaact
     2701 ggcagcgcgc atgcaggcaa ccctggccgg ccatggcgag gaagccgatc cgctgcgcgc
     2761 gctggcaacg ctggcggtgg agcgcaatca ctgattgctg gcggcgacgc tgccgcactg
     2821 cgctcaccgc gcttggcccg gcacgagcgc caaacaacaa cgcccggcaa tgccgggcgt
     2881 tgcatgtatc cgcgtgcgga cgaacttact tgatcaggcg cagcgcgaac gggtagcgat
     2941 aggcttcgcc gttgttggcc ttgacggcgg caatgatgca gaacaccagg ctgaccagac
     3001 caacgatcgg catcaggatc gcgccgatga cgacgatggt caggatcatg cagatgacca
     3061 tggcgatggc cacggtgatc tggaagttca gcgcttcctt ggcctggtcg gtcacaaagg
     3121 ccttgcccgc atcatccttg ttgatcaacc agatgatcag cgcgccgatg aagccggtga
     3181 agatgcccag caggtgcgca gccagcgcca tcgtgcgctg gtcggccggg gcctcggtgg
     3241 tcgccggcgg cggcgggacg ttatcgaatt cgctcacgac aaaactcctt ttcattgggt
     3301 ggtcttgacc caccagcacc aagctggctg cgtcaggcgg gcatagctta cgccatcgac
     3361 gccatcaatc attaccggca atggtcatcc gccccaccag gatcgagccg gtgcggatgt
     3421 gcgagcgcgg gtcaacatca ctgcccaccg cttcgatgct gctgaacatc tcgcgcaggt
     3481 tgccggcgat ggtgatgcca tccaccggat actggatctc gccattctcg acccggaagc
     3541 caccggcgcc ccgcgaatag tcgccggtca ccccgttgac gccctgcccc atcagctcgg
     3601 tcaccagcag gccattgccc atctgccggg cgatgtcctg cagcgcgcca gcattggcgg
     3661 ccaactgcag gttgtgcacg ccaccggcat tggcggtggt ctgcaggccc agcttgcgtg
     3721 ccgagtagct gcccagcacg tagcgctgca ggacgccgtc acggaccagc gccgaagctc
     3781 gggtggccac gccatcgcca tcgaaggcgg ccgaacgcag gccacggcgc aggtgaggca
     3841 gttcctcgat ctgcatccag ccggggaaca actgcaggcc gacgctgtcc agcaggaagc
     3901 tggcctggcg gtacagggca ccgccggaca ccgccgacaa caggtggccg accaggctgc
     3961 gcgccacttc cggggcgaac aacaccggca tgctgccggt ggccatcgag cgaggctgca
     4021 ggcgggcgac ggtgcgctcg gcagcacgac gaccgaccag gcccacctcc tccagatcct
     4081 cgcgggccag cgcactggtg taccagccat cgcgctgcat gccatcgccc tggccggcaa
     4141 tcagcgcaca gcccaccgaa tgatgggtgc cgcgctcacg gccgatgaaa ccatgcgaat
     4201 tggcatagac cgacaggctc tgcatgcttg acaccgaagc gccgtcggaa ttgcggatct
     4261 gcgcatcggc ctcgcggcct gcgttctcac aggccagggc caggtccacc gcctcgtcgg
     4321 cctgcagcgc ccacgggtgc caggcatcca gatccgggaa gtcggtggcc atcaacgcgg
     4381 cctcggccaa gccggcagcc gggtcatctt cggtatgccg ggcgatcgca caggcctgtt
     4441 cgaccgtggc ggcaaggctg gcctcgttca ggtcgccagt gctggcactg cccttgcgtt
     4501 gcccgaaata gacggtgacg gcgataccgc ggtcacgggt ggactgcacg gtctcaacct
     4561 cgccaaggcg gacattgacc tccaggccac gatcctcgct gcagctgacc tcggcctggc
     4621 tggcgcccag cgcgcgggca cggtcgagca gctgctggga gaggtcggcc agccgttcca
     4681 gccgggccgc gctgtcgtcg ccgacggcca cttcaggggc gatcacgttc aatgctttat
     4741 cctgtacggg ttgggcccgg catcacgccg ggcgactttt ttgaaatcag gtatggacga
     4801 tgcgcggacg cgacgaagaa accggtgaat tccacgacaa gagccgcagc cagaaccggc
     4861 gcgacgcgct cgacgtcctg gccctgggcg agaagctggt gtcgttgacc ccggcccagc
     4921 tggcgcgcct gccgatcccg gaagacctgc tgccgcatat cgccgagtgc aagcgcatca
     4981 ccgcccacat cgcccacaag cgccagctgg cgttcctggc caagcacatg cggcgcgaag
     5041 aagaggccac gctggatgcg atccgcgacg cgctggacgc caacagcgag accggccgcc
     5101 gcgaagtggc aatgatgcat cgcgttgagg actggcgcga ccgcctgctg gccgagggtg
     5161 acaaggcact ggcggccctt ctcgacgatt atccgcaggc cgatcgccag cagctgcgca
     5221 cgctggtgcg caacgcgcag gccgaaaagg ctaggaacaa gccgccgcgc gcctaccgtg
     5281 agattttcca ggtgctgcgc ggcctgatgc tgccggccgc gcttggcctg aagacggcgg
     5341 gcgacgaaga cgccggccac gtcgagaccg acgaagccga cgaggactga gtccgcgccg
     5401 gtcggggcgg tggcgctggc catcgcccgg ctcaggcctg ggtaccgccg acggtgatgc
     5461 cctcgatcag cagcgagggc tggccgacac ccacgggcac gctctgcccg tccttgccgc
     5521 agacgcccac gccctcgtcc aaggccaggt cattgccgac catgcgcacc ttctgcatgg
     5581 tttccggacc gttcccgatc agggtcgcgc ccttcaccgg cgtggtgacg cggccatcct
     5641 cgatcaggta ggcctcggtc gccgagaaca cgtacttgcc gctggtgatg tcgacctggc
     5701 cgccgccgaa gttgaccgcg tacaggccct tcttcaccga acggatcatc tcctgcgggt
     5761 cgtgctggcc ggcacgcatg taggtgttgg tcatgcgcgg catggtcatg tgcgcgaatg
     5821 attcgcggcg gccattgccg gtaggcgcca cgcccatcag gcgcgcattg aggctgtcct
     5881 gcatgtagcc gaccaggatg ccgtcctcga tcagcgtggt gcactggctg ggatggccct
     5941 cgtcgtcgat gttcaacgaa ccgcggcgtc cgtccagcgt gccgtcatcg acgatggtca
     6001 cgcccggggc ggcaacgcgc tcaccgatgc ggcccgcgta gacgctggtg cccttgcggt
     6061 tgaagtcgcc ttccaacccg tggccaaccg cttcatgcag cagcacgccc ggccagcccg
     6121 gaccgagcac caccggcatc accccggccg gagccggaac ggcgtccagg ttcaccagcg
     6181 cctggcgcag cgcctcgcgg gcgaaggcct cggggcgccc gtccgcaaac agttcttcat
     6241 acccgtagcg gccaccgccg cctgcatagc cggactcgcg gcgaccgtgg tgctcgacga
     6301 tcacctgtac gttcaggcgc accagcggcc gcacatcagc acccagcaca ccgtcgctgc
     6361 gtgcgatcag caccgtgtcg acgccgccgg acaggctcac catcacctgc ttcacgcgcg
     6421 ggtcggcggc acgcaggtag ccatccaggc gcttgagcac ctcgaccttg gcctcgttgc
     6481 cgataccatc gatcgggtcc agcgccgggt acagcgcgcg cgcgttgcca cgcagtagcg
     6541 atcgcccgga ttgggcaccg ccttcgcgtg agatcgcacg tgccgactgc gccgccgcca
     6601 gcagcgcgtc ggcgtggatg tcatcggaat aggcgaagcc ggtcttttcg ccggaaattg
     6661 cccgcacgcc cacgccctgt tcgatggaat gggcgccatc cttgacgatg ccgtcttcca
     6721 cgctccagct ctcgcggcgg gcatgctgga agtaaagatc accgaagtcc acaccggggc
     6781 caagcaactg gccgaaggtg cgctccaggc cagcggtatc caggccgccg gggcgcagca
     6841 ggcggtcttg ggcaagcgtc agggcgatgt cagtcatggt tctcgatctg gggatgcggg
     6901 ggcgctcagg caagccccgt gaacaggaag gccgcgctca ccgcgggcgc ggcaggccgg
     6961 tgacggtcgg tggaatggcc ggcgccggtg ccggcgcggg tggtggagcc ttgtcgcggc
     7021 tgcgttcgat cacttccacc ttgggctcct tccatggacc ggtcaccttg taggtacggg
     7081 cgccaatctc gcccaacggc ttggacaata ccgcattggt ggccgcgccc aacgccgctc
     7141 ccaccgggcc accggccact gcccccacca cggtcagcag gttgccggca cgcgggttga
     7201 cgtcgatggt ctggtcgaac tgctggttgc gcaggtcggc ctggccgcgg atggtgatgt
     7261 tggctgccgg gccttcgatc agcaccttgt cggtgcgcgc catgccctgg ccgaactgca
     7321 tgctgccgtc gatctggttg aacgcgaagc ccttggagaa gaagtcgcgg aagtcgaaca
     7381 tcaggcgccg cggcagctgg gtcacgctga gcaggcccag cacgcggcca gcacccggct
     7441 ccagctccag cagctggccg ttgcgtgcgt gcaggtccag gcggccctgc aggttgccca
     7501 gctggaagtc cgacggcccc ccgctccagg tggcctgcag ctgggcctgg ccggagccac
     7561 cacgcagctg gccgccgtag tccaggttct gcatcagtcc gcccagatcc tcgctgcgca
     7621 cctgggcggt cagctcggtg cgggctccgc cggcacggcc cagccagcga ccgctgatgt
     7681 cgatctcctg gtccggcgcg cggaagcgca gctcgtccac gttcaggcca ttggccaacg
     7741 gtcgtgtgcg cagcaccgcc tggcccagca ccaccttgcc gaacttgagg tcggcgatgt
     7801 ccagcgcgaa cggcggcagc ttggccgggt ccatatcgtt ggcgccggcc tggacccggg
     7861 ccggtgcggc cggtgcatcc ggagctgccg gcagcgattg ccagtgcaca cggtcgagct
     7921 ggccgctgat ggtgccgccg tcagcattgg ggacagtcag gcgcccggcc agcgacgggc
     7981 ccgccaggcg cacgtccagc gcctgcgcgc ccggatgcag ctgcaaccgg gtctgctcga
     8041 aaacgccacc gatcagcttc aattgaccga cctgcacgtc caccgcacgc agcggcatcg
     8101 tgttgtcatc gctgccgccc cgcgccaggc cgatccactc caatgcgtcc aaggtcgggc
     8161 tgcggccgtt gacggtcaat ccgctgggcg gcggctcgcg atcgacatgg tcgctgccca
     8221 gcgtcacctg cacgccggtc tggttgttgt ggctgcgcgc ggccagcgcc aggcgctggc
     8281 cgaacgccac atcgatgcgg ccggcaccca tcggcagctg tgcggccacg gtggtcgcca
     8341 gcggctcggc agccggtttg tccagcggcg ccggcagatc cagccgggtg ccgaccagat
     8401 cggagctcaa gcgcagctcg ctgggcggcg caggagcacc tggcgccacc ttgggcaggt
     8461 tgaccgcgat ggtccacggc gaggtcccgg tgatgtaggg cttgagccag gccatctccg
     8521 gtgcgcggtc gatcagcacg ccggcgtcaa gcgtggccga cagcttcgat tcgaaggcca
     8581 gtctgctgtc gtgcacgtag ccaccagcac gcaggctcag gcggccgtcc tggccgaggt
     8641 ggcgcaccga cagttcctcg gcatcgaaac cgccattgct gtagcgcgcc tgcccgtgca
     8701 tgttgtcgaa ggcgagctgg aaacgcttgt cgaccagctt cacgccggcc aggtcaaccg
     8761 tcccctgcag atggccaccg cctttatcgt ggtgcagcgg ttgcagcaga tcgaaggtca
     8821 catgcgccgg gcccgctgcg gtgaggttgt ccagggtatc gccatagtcc ttgtgcagcg
     8881 ggctctgccg cagcatggcc agcagtctgc cggcctcgct ctgtgcatcg gcgcgcacgt
     8941 acagcggctg ctgcccgaaa tcctggatgc ccgcctcgaa cttctgcacc gccacgccgg
     9001 ccaggtcgcc gcgcccatgc atgtcgaagc cggggccgat gaaggcgata tcggcatcga
     9061 cctggctcat cagcggccaa tcgtgctgga agcggatgtc gccattggtg atgtggccgg
     9121 tggcctcgaa gcggccatcg ttgttgtcga acggccagtc gtccaggtca ccggtgacca
     9181 ggccgacgcc gccacgtacc tggccgccgg ccagtgccat gtccagccag tcggtggcgc
     9241 ccttgctcat cttggagtgg atccagaagc gcttggccgc cgtcatcggc acgtcgtcca
     9301 gcttggcggc cagctgcagc cacggccgcg taccgtcgcc ctggaaccac acaccgccgc
     9361 gcacgtcggc cgcatagtcg gtaccttcca cacgcatcgc cggcgtcccg atccgccaac
     9421 caccgccctc gtcgcgccag cccacgatct gcccggccag ctgcaggtcg tggcgcacgc
     9481 cgaagccggt gggccaatcg aactgcagct gccgttgcgg ctgcagctgc aggctgaagc
     9541 cattggcatc gccttcgaaa cgcccgccaa ggccgcgcag ccccggtgaa ttgccgacgc
     9601 ttgcaaagcc cagcgactgc agttcaccct gcgcccacaa tgggccatcg cgttcgccgg
     9661 ccagctgcaa cgcgcgcacg tccagctgcg gcctggacag gaacagccag cgacgcaggc
     9721 ccggctcaag gcgatcgctc agggccagcg cacgcagcgc gatgccggcc tgcacttcac
     9781 cggaacgcac ccgcagctgt ttgccgacct gcagctgcag gccatcgagg cgctgctcgc
     9841 cgtcttcatt cttcagccgc aggcgcggta cctgcagcgc ccagccctcg gcctggcgct
     9901 gccagcgcag gcgggcctgc agtcgctgca gctgcagctg cggcgccgcc atgccgggta
     9961 tcggtgcgcc atcgatgcgc acgtcgcgca ggtccgaatc cgtggtcacc gccaccggca
    10021 cgaattcgcg cagggtcaac cacaggttga gttcgccctt gccctcgcgc aggcgcacac
    10081 cgccggccgc caacagcgga gaccaggcat ggaaatcgac cggatcggcg cccagccagg
    10141 cctcgccgtt gccacgcgtg cggtccacat ccagcaccgc agtcaatggc agcgcttcgg
    10201 cctgggccca ggcgcgcacg cccacgcgca ggcgatcgcc attgacccgc aggcgcaggt
    10261 cgatgcgcgg cagcgtggtg tcgatgccca acgtcggcga gtgcacgccc aggcgccccc
    10321 cgatcacctg cagctcgccc agccggcgca gcgcatccag cggatctcca ccgtcggcgg
    10381 actgtggcag cccacgcacc gaccagcgac cgcttgcatc ctgctgcaga tccagcgcca
    10441 gcccacgcag gcgcaactcg gtcagcgaac ggccaggcaa caggccgctg tacatcgata
    10501 ccagcacctc ggcctcgcca atggccaggc cgcggcccgc gccgatatgc aggcctttga
    10561 gctgcagcaa cgggccacga cgggtccagg ccgtctgcag ctggtcgaaa cgcaccggct
    10621 ggccggcacg ttcgctcagc caggccgcaa tcctgtcggg gtggcgctcg gccagcggca
    10681 gcagctggct gagggtgccc accagcagtg ccagcccgac caggcccacc gcgcaggcgg
    10741 caatgagatg acggcggatc cttcgcagtc gcaggcgcgg cggcgcgctc atcggccacc
    10801 gccggcctgc agccggcgag gatcagagca gaacgacatc gaactgctcc tgcaggtatt
    10861 gctcgtccgc ctggaagcgg atgctcttgc cgaggaattc ctccagctcg gccaccgccg
    10921 ccgattcctc gtcggtgatg cgcgcgacca ccttggtcga ggcgatcacc agcaggcgcg
    10981 cggcgtcgaa ctggcgcacc gcgcgggtga tctcgcggaa gatctcgtag gtcaccgtct
    11041 cggtggtctt gatgctgccg cggccgctgc actgcgggca ggtttccgac agctggcgct
    11101 ccaggctttc caccgtgcgc ttgcgggtca tctccaccag gcccagcggc gagaagtcat
    11161 agactgttgt cttggcatgg tcgcgcgcaa gcgccttttc cagcgtgcgc agcacctggc
    11221 ggcggtgctc ggcatcatcc atgtcgatga agtcgatgat gatgatgccg cccaggttgc
    11281 gcagccgcag ctgccgcgcc accgcctgcg cagcctccag gttggtgcgg aacaccgttt
    11341 cttccaggtt gcgctggccg aggaacgaac cggtattgac gtcgatggtg gtcatcgcct
    11401 cggtctggtc gatcaccagg tagccaccgg atttcaacgg cacctgcttg tccagcgcgc
    11461 ggccgatctc gtcctccacc ccgaacatgt cgaagatcgg gcgatcgccg gaatacagct
    11521 ccagcttctc ggccagcacc ggcatgtact tggcgacgaa ggcctgcagc tggccgaagg
    11581 tctccttcga gtccaccttc accttgtcca catccttgcg gatcaggtcg cgcaccgaac
    11641 gcagcggcag gctcaggtct tcatagatga tgctgcacga gggcgcttcg cggccacggc
    11701 gctcgaccac gttccacacg cgcgacaggt aggcgatgtc ctcggcgatg gcctcggccg
    11761 gctggccttc ggcgttggtg cgcacgatgt agccgtagcc gccgtgctgc gccgacagct
    11821 cggtcaccag cgccttcagg cgggcgcgct cggcttcgtc ctcgatgcgc gccgacacgc
    11881 ccaccacctt ggactgcggc agcagcacca tgtagcgcga gggaatgctg atctgcgtgg
    11941 tcaggcgtgc gcccttggtg ccgatcgggt ccttcaccac ctgcacgacg atgtcctggc
    12001 cgtcacgcag cagctcgaca atcggcacgc tggccggcgg cggcagggtg gtgttctcgg
    12061 tatcggcact ggccaccggc gccggccgca ccacgtcatt ggcgtgcagg aacgcggcgc
    12121 gctccagccc gacttcgacg aaggcggcct gcatgccggg catgacccgc tgcaccttgc
    12181 ccttgtagat gttgccgacc acaccccggc gccagccacg ctcgatgtgc agttcctgca
    12241 gcatgccatt ttcgatcacc gcgacccggg tctcgcgcgg ggtcacgttg accaggattt
    12301 cctcagacat ctgcagcctc cctggcggca tcggcggtgg gggccggcac gccgcagcgc
    12361 gccagcaaac gatcggtgtg cagcaacggc agccccatga cgccggagta gctgccggac
    12421 aggtgctcga tccagcgctc ggccccgccc tggatggcgt aggcaccggc tttgtccagc
    12481 ggttcgccgg tggcgacata ggcggcgatg tcggcagcgt cgatcggggc gaaggtcact
    12541 tcggaaatga ccagttcgct gtccagcccg tccgcgccga ccaccactac ggccgtcatc
    12601 acctggtggg tacgcccggc aagacgcgcc agcatccccc gggcatcggc agcgtcggcg
    12661 ggctttccaa acacctcgcc atgcagcacc acctcggtgt ccgaaccaag caccctcgcc
    12721 tgcgggtcat tggccagcac ccgggccagg ccggcgcgtg ccttttcggc ggcgacccgg
    12781 cagacgtact gttc
//
