LOCUS       NZ_KB905819            24571 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Streptomyces sulphureus DSM 40104 F603DRAFT_scaffold00007.7, whole
            genome shotgun sequence.
ACCESSION   NZ_KB905819
VERSION     NZ_KB905819.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sulphureus DSM 40104
  ORGANISM  Streptomyces sulphureus DSM 40104
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 406601)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name :: Streptomyces sulphureus DSM 40104
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 40104, ATCC 27468
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R37654
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11971
            Current Finishing Status          :: Level 1: Standard Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Sporulation                       :: Sporulating
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R37654
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000381025.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 01:54:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,193
            CDSs (total)                      :: 6,120
            Genes (coding)                    :: 6,022
            CDSs (with protein)               :: 6,022
            Genes (RNA)                       :: 73
            rRNAs                             :: 6, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 1, 3, 1 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 98
            CDSs (without protein)            :: 98
            Pseudo Genes (ambiguous residues) :: 0 of 98
            Pseudo Genes (frameshifted)       :: 37 of 98
            Pseudo Genes (incomplete)         :: 75 of 98
            Pseudo Genes (internal stop)      :: 11 of 98
            Pseudo Genes (multiple problems)  :: 20 of 98
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:55:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10721
            Orig. end                         :: 35292
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905819.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405920
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24571
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24571
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24571
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14571](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14571)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    66..86
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.41"
                     /tool="antismash"
     misc_feature    422..437
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.56"
                     /tool="antismash"
     misc_feature    complement(1021..1035)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     tRNA            1373..1433
                     /anticodon=(pos:12114..12116,aa:Gln,seq:ttg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="F603_RS35150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Gln"
     gene            1373..1433
                     /locus_tag="F603_RS35150"
     gene            complement(1565..2329)
                     /gene="madM"
                     /locus_tag="F603_RS0119360"
     CDS             complement(1565..2329)
                     /GO_function="GO:0005342 - organic acid transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015849 - organic acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="madM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906173.1"
                     /locus_tag="F603_RS0119360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malonate transporter subunit MadM"
                     /protein_id="WP_019547634.1"
                     /transl_table=11
                     /translation="MDTLVSVFEENDLVVAFALVGGLMLVSGWLSKKLSRGRLHGSAVA
                     ILLGLVLAYWGGTVTGGEKGIADFAVFSGLGLMGGAMLRDFAIVSTAYGVDLKEIKRAG
                     LSGALSIVLGVVLSFVVGVVIAALFGYTDAASLATIGSGAATYIVGPVTGTAVGASSDV
                     IALSVAAGLVKSVVVMVGTPLIAPLIGLNNPKSAMAFGGLLGTTSGVAGGLAATDKRLV
                     PYGAMTATFYTGIGCLLGPSLLYVTLRAVVGG"
     gene            complement(2331..2732)
                     /gene="madL"
                     /locus_tag="F603_RS0119365"
     CDS             complement(2331..2732)
                     /GO_function="GO:0005342 - organic acid transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015849 - organic acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="madL"
                     /inference="COORDINATES: protein motif:HMM:TIGR00807.1"
                     /locus_tag="F603_RS0119365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malonate transporter subunit MadL"
                     /protein_id="WP_026328559.1"
                     /transl_table=11
                     /translation="MVLYGVAALAVCMLAGTLVGEVLGIAVGVDANVGGVGFAMIMLVL
                     VSHWLRGRGKFPEPTEQGVLFWSAMYIPIVVAMAATQDVAGAIAGGPMAILAGLGAVVA
                     GAALVPVLARIGSPAEPLPPQDADEKQEV"
     misc_feature    2721..2736
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.76"
                     /tool="antismash"
     gene            complement(2893..4428)
                     /locus_tag="F603_RS0119370"
     CDS             complement(2893..4428)
                     /NRPS_PKS="Domain: AMP-binding (11-404). E-value: 1.3e-103.
                     Score: 338.7. Matches aSDomain:
                     nrpspksdomains_F603_RS0119370_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906175.1"
                     /locus_tag="F603_RS0119370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_019547636.1"
                     /sec_met_domain="AMP-binding (E-value: 5.7e-112, bitscore:
                     368.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPFTTIHRSFVEQAERRPDKALFELPDGRGVTYRKTAETVQRIA
                     ARLVADGVAPGDRVAAQVHKSPEAIALYLATLQVGGVFLPLNTAYTGNETGYFLGDAQP
                     RVLVCAPERETEHTRRAQEGLVIETLGVSGDGSLLDDDARRTETYEASADDPAAILYTS
                     GTTGRSKGAVLTHGNLAANCRALLDSWRFTADDRLIHALPIFHIHGLFVAANMALTAGA
                     SLHYLPKFDADAIVDLLPRATVLMGVPTFYTRLLKHPGLTAETCAGMRLFVSGSAPLLA
                     GDHESFATRTGHAILERYGMTETGMNTTNPYEGGPRKPGTVGKPLPGTEIRVVDAESGE
                     PLPDGEVGSIEVRGPNVFTGYWRLPEKTAAEFRADGFFVTGDLGRIDEDGYLCLVGRGK
                     DLVITGGYNVYPKEIEELLDAHPEVVESAVIGVPHPDFGETVVAVVVPTPGAQPAAEEL
                     REFVAGDLARFKHPRAVRVVEALPRNVMGKVQKAELRKRYESLFTPPASPADT"
     CDS_motif       complement(3184..3246)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F603_RS0119370_0003"
                     /evalue="1.50E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="F603_RS0119370"
                     /protein_end="415"
                     /protein_start="394"
                     /score="14.6"
                     /tool="antismash"
                     /translation="VGRGKDLVITGGYNVYPKEIE"
     aSDomain        complement(3217..4395)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F603_RS0119370_AMP-binding.1"
                     /evalue="1.30E-103"
                     /label="F603_RS0119370_AMP-binding.1"
                     /locus_tag="F603_RS0119370"
                     /protein_end="404"
                     /protein_start="11"
                     /score="338.7"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VEQAERRPDKALFELPDGRGVTYRKTAETVQRIAARLVADGVAPG
                     DRVAAQVHKSPEAIALYLATLQVGGVFLPLNTAYTGNETGYFLGDAQPRVLVCAPERET
                     EHTRRAQEGLVIETLGVSGDGSLLDDDARRTETYEASADDPAAILYTSGTTGRSKGAVL
                     THGNLAANCRALLDSWRFTADDRLIHALPIFHIHGLFVAANMALTAGASLHYLPKFDAD
                     AIVDLLPRATVLMGVPTFYTRLLKHPGLTAETCAGMRLFVSGSAPLLAGDHESFATRTG
                     HAILERYGMTETGMNTTNPYEGGPRKPGTVGKPLPGTEIRVVDAESGEPLPDGEVGSIE
                     VRGPNVFTGYWRLPEKTAAEFRADGFFVTGDLGRIDEDGYLCLVGRGKDLVIT"
     CDS_motif       complement(3313..3402)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F603_RS0119370_0002"
                     /evalue="1.60E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="F603_RS0119370"
                     /protein_end="372"
                     /protein_start="342"
                     /score="20.5"
                     /tool="antismash"
                     /translation="PDGEVGSIEVRGPNVFTGYWRLPEKTAAEF"
     CDS_motif       complement(3901..3960)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F603_RS0119370_0001"
                     /evalue="5.40E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="F603_RS0119370"
                     /protein_end="176"
                     /protein_start="156"
                     /score="22.1"
                     /tool="antismash"
                     /translation="AAILYTSGTTGRSKGAVLTH"
     gene            complement(4428..5813)
                     /locus_tag="F603_RS0119375"
     CDS             complement(4428..5813)
                     /GO_function="GO:0050080 - malonyl-CoA decarboxylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547637.1"
                     /locus_tag="F603_RS0119375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malonyl-CoA decarboxylase domain-containing
                     protein"
                     /protein_id="WP_019547637.1"
                     /transl_table=11
                     /translation="MEQHDGWLLADLFQALGRRRDGAPEPGEPDSALEQLLVACEVLMS
                     DVGEASMRAVAARALAAYAALDDDGRRTFFAHVTRTYDVDADQVRAAFHRWESARQAGL
                     HGEAELVHLFDVVEPARQQLLRRMNHAPDATPALVDMRADLRRLMHDHPELRPLDHDFL
                     HLLTSWFNRGFLRMAEVTTDSPPDLHAHLLQHERVHPMADHEELRRRLQPADRRIFAFF
                     HPATGDVPLVFVEVALVRGLPQHIAPLLDPGPEIDPASADTAALYSINNALDGLAGVSF
                     GSFLIKQVIEQVGEQLPHLTQFATLSPIPGFRRWLLKHAEHEPELERLAAELEASAGTR
                     ALTPPDLERMRSMLLPVLARYIARERREDGRPVDAVARFHLGNGATAWKLNWPANTSPE
                     AWEQSYGAMVNYRYEPDRLERQHEDFVRRRTVALGGPLQDVLPETEPPRPHASEPGSEK
                     GTP"
     misc_feature    5774..5788
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     misc_feature    5869..5887
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.31"
                     /tool="antismash"
     gene            5956..6633
                     /locus_tag="F603_RS0119380"
     CDS             5956..6633
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906177.1"
                     /locus_tag="F603_RS0119380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_019547638.1"
                     /transl_table=11
                     /translation="MARVPEAERVRDALENAVINGRYRPGERLDPALLEREFGCSRTPV
                     REALQTLQRSGLVRIRPKQGTYVTELSVSELGERFEVMAELEGMAARLSARRIAQEALD
                     DLARTLHECAEHAAAGDADRYYYANARFHDVVYDSCGNEYLREQAQALKRILQPYRRLQ
                     LRVPDRMRRSLGEHREIAAAIRAGDAEAAEDAARDHVLVQVKEFSQLVHTWKHLTEPVG
                     RVE"
     gene            complement(6950..8221)
                     /locus_tag="F603_RS0119385"
     CDS             complement(6950..8221)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547639.1"
                     /locus_tag="F603_RS0119385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6895 family protein"
                     /protein_id="WP_019547639.1"
                     /transl_table=11
                     /translation="MTAPPHASWPQLPSHAGSFSAQRTERECAVEVLTRALSWLERYAE
                     WFRPQRWEELLPARPFRPGPLLELLALVRVLRRSRALTGGEALARRALDLAEEAVAEDE
                     FATGLRRADALLPYHVNLVGLLGTLGRPQPELHAAAQSLVAAGAGGHHLPYKPVLNRLE
                     LRYFLDRGGFTAPPALPTPAELYAQTLAAQCPHVLHLDDDETYALTHVLFYTTDFGATT
                     GPPAAEHHPARLRQCVRTLLGVHLARGSLDLVSELLLCTTALGGAPDPAAASRYAWNTL
                     RTAQRPDGAVPSPVHMPSRWEELRHNRADAYLFGTCYHTTLAAALASAVLLERPRPPQP
                     RTDTATPCPPPPASPDALASWLDDAHPAREPTALQAYLPSVLVLCTRARDAPLLRRALD
                     AAEAAGLAAHPLVGEAAALARCLR"
     gene            complement(8218..9009)
                     /locus_tag="F603_RS0119390"
     CDS             complement(8218..9009)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906179.1"
                     /locus_tag="F603_RS0119390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_019547640.1"
                     /transl_table=11
                     /translation="MTATTAPAPAEETVLSVSLRAVAVIAHRDLLRQVKRPGVLLSQGV
                     QILFFVLVYAVGFDGMIGSVGGVPFSAYVFPGIVAIQVVSIGVASGQTYAWDREFGVLR
                     ELLVAPVPRICLPLGKVVAGAGMVTVQSALMLAFAPLMGLELTPVRYAAAVGCYALAAT
                     VFSVIGLCLATVIKQMQTLQATVQLAMFPMLFLSGSVFSAADAPVWLAAVMHLNPMTYA
                     VDLARQTLLGGHGLLVWWADLAALGAILCGVLILLRTRSGK"
     gene            complement(9006..9944)
                     /locus_tag="F603_RS0119395"
     CDS             complement(9006..9944)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547641.1"
                     /locus_tag="F603_RS0119395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_019547641.1"
                     /transl_table=11
                     /translation="MEAAPAFEVADLVVRYGKVTAVAGVSVDSPPGRITALLGPNGAGK
                     SSLLGVLSTASRPDAGRVRIFGHDVGAAPMAARRRLGLVFQERTLDKELSVERNLWFHA
                     RLFGMTRSDARSRIALLLGLFDLADRRRQPVEQLSGGLSRRLEIARALLHRPGLIILDE
                     PTNGLDPSARSTVWTDLLRLRTELGVTVLYSTHYMDEAEYADEIVILQQGSVVRRGGPE
                     ELKDGLASSRILVSCADPADHGTAERQLRAAGFPTLSEAGGLAVHCAEPEARIAEVVRV
                     LDVPGLTVSVRHPSLNDVYLAAAGQESASPR"
     misc_feature    9922..9937
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.34"
                     /tool="antismash"
     gene            complement(10001..11359)
                     /locus_tag="F603_RS0119400"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906181.1"
                     /locus_tag="F603_RS0119400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_019547642.1"
                     /sec_met_domain="LANC_like (E-value: 7.8e-53, bitscore:
                     173.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRTCTVSAAEAVSLVAERLADPAHTAAVASRDDNRDPVYDAVMW
                     GPMTLANGLPGTALLYGELTRTDERWRTVAHRHLQAAAGAMATSPSHGLFSGPASLLAA
                     AQTCAGLDGHYATLRSRLARWVADDQATRLRAFDARARTPGVGWGAYDLVNGISGTARL
                     LLDSATDPAEVSPEVESALDASLRHLVRLTEPVHVDSDVLPGWWVPAELQVSDRDRRTY
                     PRGDLNLGMAHGIAGPLSVLAASCTAGREVPGTRDAVRRIAEWLLGWTLHDDAGPYWPA
                     RVPREDETASRSKRPSALFTRTAWCYGTPGVAAALHRAGCALGERPWCRAAVTALETAL
                     RRDPSRWAIEGPTLCHGFAGLLRIVLRVADEAGNAELAARAEPVRRRVLELADESAPFG
                     FRHLMRHPAAARSPDPHRALNVAGLLEGAAGVALALLPPNTSPLAWDRCLGLA"
     gene            complement(11356..14571)
                     /locus_tag="F603_RS0119405"
     CDS             complement(11356..14571)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906182.1"
                     /locus_tag="F603_RS0119405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_019547643.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.9e-175,
                     bitscore: 578.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.7e-15,
                     bitscore: 50.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.6e-39, bitscore:
                     128.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEPSISDTDRRDGGNLFRAADLFLCRSPLNPQAPGLPTGHAGGP
                     REREACAAVLASAGDDAALHEALLLASPSLASLVHRVRAHGAEGITDARLRRAALAVLR
                     YDVRRRTRPTPFGLFAGVAVGTFDSTAKAERGPAHRTRTHVDMQWLTRVGNRLEADAAV
                     LSCLDVQAHQGLRVRGDRLVLTYPSTRGVPPRGDGPDRSTVSVRRTPLVAEAVAKARCP
                     VPYGELVGDLSAAFPGVPVERVRTLLAALVREELLITEVRPPLDGGDPLRHLLDVLDRA
                     SGGGGTSEETEELRLALHRLDGARHAYDALPVGAGAGRLRHLLDTARAAEPDDTPLHID
                     TRLDTELRLPHVVRSEVERAAEVMWRLSRPKLGLFALREYHRRFLDVYGADRLVPVLEL
                     LDEATGLGAPAGYGWPNSEAPEVPPEDARSLGRDRAMARLVARAQRAGLREVVLSDAEL
                     AEFARGSADPADLPSSCEVTVQVTAPGAEALGEGEFRVFLSPSPGSHRAGSTFARFADL
                     DPEWRARFAALDRDVPTHVAGAVPVDLAFRPRGGRAANLAHTVPGTGRRVSVGVPNAGD
                     VEELPVAEVGIGATLERMTAVHLPTGRELAPVLGNMVSAPAQAPNAVRLLWEIGLEGQR
                     LWEPWNWGPLADAPFVPRVRHGRFVLASAVWRLDELRAAAEESHAGWEAALSRWQEFWQ
                     VPRLVLAVAADQRLTLDLDDAWHRELLRDQLCRNPELIAQEVPGEHEGWLESPFAGHTT
                     ELVVPLTRRPDVPPRRGYAGHHQPQRTVHGLGGNWLYLKLHGPARCQDELLRDHLPALV
                     NLAGEEGAESWFFLRYTDPSGHHLRVRLYAESADRLWGRVAPAVGALLEEWQRAGLVRS
                     HTLAQYDPETERYGGPTAQHLAEQVFRYDSEAALELLRLAKEPENGHDAESLAAVSVAS
                     LAHAFGPPDPEDPLLTGDFGDDSAAAWLSMTGSRRDLPQEYRPGAGQWRRLVDPYAGFP
                     ALAGDGTGLRIREALLPRDEAVRRLASRVREASSTPRGRIVGSLLHMTCNRLFGGDSAQ
                     EARVLGIARGAVQDNLNRRRHHA"
     aSDomain        complement(13780..14049)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F603_RS0119405_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="3.00E-16"
                     /identifier="RREFam001.1"
                     /label="F603_RS0119405"
                     /locus_tag="F603_RS0119405"
                     /protein_end="264"
                     /protein_start="174"
                     /score="50.9"
                     /tool="antismash"
                     /translation="LRVRGDRLVLTYPSTRGVPPRGDGPDRSTVSVRRTPLVAEAVAKA
                     RCPVPYGELVGDLSAAFPGVPVERVRTLLAALVREELLITEVRPP"
     gene            complement(14658..14828)
                     /locus_tag="F603_RS34750"
     CDS             complement(14658..14828)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="F603_RS34750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_019547644.1"
                     /sec_met_domain="TIGR03731 (E-value: 5.2e-10, bitscore:
                     33.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGINSPADVRNDEGLLDLDLEIGVEKSVAGPAVTSISYCTPGCTS
                     EGGGSGCSHCC"
     CDS_motif       complement(14733..14828)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MGINSPADVRNDEGLLDLDLEIGVEKSVAGPA"
                     /locus_tag="F603_RS34750_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14658..14732)
                     /prepeptide="core"
                     /locus_tag="F603_RS34750_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="9.60"
                     /molecular_weight="2152.4"
                     /monoisotopic_mass="2150.8"
                     /core_sequence="VTSISYCTPGCTSEGGGSGCSHCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGINSPADVRNDEGLLDLDLEIGVEKSVAGPA"
                     /leader_location="[14732:14828](-)"
                     /alternative_weights="2170.4"
                     /alternative_weights="2188.4"
                     /alternative_weights="2206.4"
     misc_feature    complement(14872..14888)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    15049..15063
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.23"
                     /tool="antismash"
     gene            15058..15615
                     /locus_tag="F603_RS0119415"
     CDS             15058..15615
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547645.1"
                     /locus_tag="F603_RS0119415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_019547645.1"
                     /transl_table=11
                     /translation="MCSDETLLTAAAHGDQSALRDLYERHAAAMLRLIRRLTSDQGAAE
                     EILQESWLAVWRSATGFRGESSVRSWLLGVARRQAHNQLRRSRPRFADLAEAYEVPDPA
                     PGVEEQVVVAAERDALRTAVRALPEHLREVLALVLVEDLAYPEVAEVLEIPVGTVKSRM
                     SHARKRLGNMLAATRLEGTARR"
     gene            15612..16514
                     /locus_tag="F603_RS0119420"
     CDS             15612..16514
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906185.1"
                     /locus_tag="F603_RS0119420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019547646.1"
                     /transl_table=11
                     /translation="MKQPPHLEDDSLAALAKSTADGARPAHLRECAACRSRLAWWQGVT
                     DAVRTDEAARNAAAPSFDTLIAPVLTPQTATQPQPVLSTAPHRPSPARTLRLAGQLVQR
                     QTKLLPRAWAPLSAVGLLAAALLAPLLGDPSTTLRAFSAAAVLVLLLGALLVSSPRTDP
                     RHELMHTLPTSPTSVFLARTTAVLTLDLLLALGCSALLGDLGWWTAVSGWLGQGLLAST
                     AALALSLRLGAATGASAGAAIWLLSVLTGPDGLLTSPLAVVLNPLLTTSWWTLALSALL
                     LGWAVRQVRRSPDAVAEPA"
     gene            16640..17272
                     /locus_tag="F603_RS0119425"
     CDS             16640..17272
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906186.1"
                     /locus_tag="F603_RS0119425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019547647.1"
                     /transl_table=11
                     /translation="MRTASNTAPPQASWAQEARRCGRTALLLPALAAVAAFAAFSAGPP
                     EGTLPGRLVLECALPVATALACATVVVREPMAELHLTLPTGYPRTVTRRLALVGAASAV
                     SALLLVAGLLATGSSPAPAATLSELLALTVLLSGTAVWSAVRLGSGAAATGTVAAVVLA
                     KVLLLDQALPQATVQAPWALLAGGVLFLFALRTLADAERSALRLLEV"
     gene            17272..18066
                     /locus_tag="F603_RS0119430"
     CDS             17272..18066
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906187.1"
                     /locus_tag="F603_RS0119430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019547648.1"
                     /transl_table=11
                     /translation="MNALLCTVRYEALMAVRRKAVLGTVVPLTALSLLLAVTSPVVTGH
                     TDPTARVGAVVVLVNTFCALGVGIALADRLRRGMETRGLADVLEATPTAALARSLGASL
                     GPLLTALTPVAAPLLLFGAVVAAAAASIVPLVATLAALVTAVLPAALLAASLGGLLGAL
                     MPVAAARGVLVAAWLWAVQLPPSLSPVPTPTGTVFSPLGGYPLVAWAHAPEVWARREST
                     GFARPEVTDTTALLNLALVLALALACYALGHLATRLRRHGAP"
     gene            18063..19010
                     /locus_tag="F603_RS0119435"
     CDS             18063..19010
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547649.1"
                     /locus_tag="F603_RS0119435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_019547649.1"
                     /transl_table=11
                     /translation="MNITTRRLAKVYRGGHRALDDVDLHVEGGTVGLLGANGAGKTTLL
                     RVLTGILRPTSGTVEVAGHDLATTAGRTAVKRTLGYLPQELSLYPDLTAREFLDYIGVL
                     KGLDDKRERRRQVEEHLGDVGLEDAAGRRLSGFSGGMKRRVGIAQALMGEPTVLVVDEP
                     TTGLDPHERMRFRRLLAGLGRGRTVLLSTHILDDVAQTCREVAVLDAGRLLFHDTTAAL
                     VSQAAGRTWAVTATEVGGGPPPEADVVSAATTSAGAEYRMVADAAPAGGRPAEPTLEDG
                     YAALLRDHAPTRAHATAGHSTARSTAEPPSHERK"
     gene            19016..19453
                     /locus_tag="F603_RS32445"
     CDS             19016..19453
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F603_RS32445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="DUF2511 domain-containing protein"
                     /protein_id="WP_019547650.1"
                     /transl_table=11
                     /translation="MSPAAPPAAAPRAELRTHTRRHGALLGAALAALVLAGTAGCKGEG
                     RADPATTDPAPLPSPTSTKQEIGEENFAYTWPFTVPRGTAECRDGDKAVFTVQGGTTYA
                     LNDRARQAGYPDVGPIRASGSGGGDISLGTVLSRALKLCNP"
     gene            19576..20277
                     /locus_tag="F603_RS0119445"
     CDS             19576..20277
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547651.1"
                     /locus_tag="F603_RS0119445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_019547651.1"
                     /transl_table=11
                     /translation="MFEQAGSRTEPGRQVIAHHALRELLDSPHTPLGRLRAQLPDIRFV
                     AYRDLAAETSVLTRPLLMPSTTEFQNEELRAVRLNQATALIVAVTHDVSGHQAYHAIRS
                     GADLVFNLANPSREQLDAVCARCVSHSSAVVGLSQHSRSSSVEAAGEVRPDGHPGPYDE
                     ELLRLLGTSLTVSEIARRFYCSERTMYRRIRHLYDAFGVSRRSELMAAVSRANGRPNVV
                     AGRNLSSSDAS"
     gene            complement(20340..21098)
                     /locus_tag="F603_RS0119450"
     CDS             complement(20340..21098)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906191.1"
                     /locus_tag="F603_RS0119450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_019547652.1"
                     /transl_table=11
                     /translation="MPGAQQTDTAPSTPTERTALTIRGLHKHYGSHRALDGVDLSVETG
                     EVYGLLGPNGAGKTTLMKAMLGLQRPSSGTIEIFGRPVGRESLAQVGALIEVPGLWPTL
                     TAAETMKVHARLRGVPEEWIAPALQTVKMDGVGGRRVGAYSLGMRWRLGIAVALLARPR
                     LLLLDEPTNGLDPVGIKEMRGIIRALADEGVAVLLASHQLAEVAQVCDRVQVLVEGRTR
                     YEGALAGLAPDGDLEQGFFRLVESADARIR"
     gene            complement(21100..21903)
                     /locus_tag="F603_RS0119455"
     CDS             complement(21100..21903)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906192.1"
                     /locus_tag="F603_RS0119455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_019547653.1"
                     /transl_table=11
                     /translation="MTVETSAPPLARGRDAPSLVTVVGTELIRHRRGFLLWYHLLAPVI
                     ITVPLFLGSLGSSEAKAGRTFEVFQNVTLEFWGVLVPMTAGLAAALSVRADQDAWRLLL
                     SYGVPRGRYFVGKVAALGVLGFVSSTVLLLMLALGAALAGAFPEAMGTVLPAVYLPWLV
                     GLSMTALAVLCAVVWGMGPSIGIGVAGLLCGALVSDKVFWFAVPFAWPMRVVLPLAGIG
                     PNGVPLPEDSPVRDPSAIPLALGLAAALTAVLIVVGRVHMSRKEI"
     gene            22146..22454
                     /locus_tag="F603_RS0119460"
     CDS             22146..22454
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906193.1"
                     /locus_tag="F603_RS0119460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019547654.1"
                     /transl_table=11
                     /translation="MKTLRRGIAATTVVLALGGLVAPAAVAAEQAAVAPSSSVAVMKTW
                     HATVQCQIVRISDNNAIRYERADGSGNTKEKAKKAAERNIHVPKGHYKRHCDVKRYW"
     gene            complement(23422..23754)
                     /locus_tag="F603_RS0119470"
     CDS             complement(23422..23754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547655.1"
                     /locus_tag="F603_RS0119470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="co-chaperone YbbN"
                     /protein_id="WP_019547655.1"
                     /transl_table=11
                     /translation="MTATADLLAVTDADFEKEVIASPIPVLVEFTASWCSPCRMMLPVL
                     TQLAAERAGALKVLTMDVESNPRTQSDYSVLAMPTLIGFRNGEPITSLVGAVSGLRLRE
                     HFAGLL"
     gene            complement(23751..24245)
                     /locus_tag="F603_RS0119475"
     CDS             complement(23751..24245)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019547656.1"
                     /locus_tag="F603_RS0119475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_019547656.1"
                     /transl_table=11
                     /translation="MRIGELAHLAETTPRTLRYYESRGLLTSRRDAQGHRTYDPVAVLQ
                     LRQIRVLRKIGFGLEETKPFLDCLQAGHTEGDACPASLDAYRSKLAELDSLTARLDTVR
                     QEIEDRLRRAQEPPAPSEPKGDVPACMLTSNSLPGPPSSPNRSAQATPSLRLTVPHKEK
                     R"
ORIGIN
        1 tacccgcccg agcagcacgg cgagcgccgt aagcgccgcg actgcatcgg ctcgtggcag
       61 gcccgatacc gggacgctga cgacaagcag aaggcgaaga acttccccag gaagaaagag
      121 gccgacgcgt tcctcgacaa ggtccgcggt gctgtccgac agggaacgta cctcgacccg
      181 aagcgcggcg agatcacggt cgaaaagtgg tgggccgagt ggtggccgtc gcacgagccg
      241 tcacgcacca cgacgaagaa ccgcaagctg tcgtcttgga cggtgcacat acagcccaag
      301 tgggggcggc ggaagctcaa cagcctcacg taccttgagc ttcagacatg ggtcgcccaa
      361 gagctgaagg ggtacgcgac gcagaccaag gtcctggagc tgttgaacat gctcctgcgg
      421 gacgccgtac gcgatcagcg gatcacgaac aacccgtgcg ccgacgtcac caagacggcg
      481 agtccgccga ccaagcaccc agatgatttg cggcctccta cgctggagca gtacgcgctg
      541 gtgagggccc aactaccggt ctggtaccgc ccgatcgtcg actggttgga ggacacgggc
      601 ttgaggtggg gcgaggccat cggcacccgc cgagcgttcc tcgacctggc cactgacacg
      661 gtcaaggtga gggaagtggt catcgacgac cgcggcgtgc tgcgtcggca gggcatcccc
      721 aagaccgtgg cgggattccg cacggtgccg ttgacgcaga aggcgaagaa tgcagccctg
      781 gccatggtgg accggctcga cccggcgtac acggtgacgg ccatcgagga tggcatgcac
      841 tccgaagagc tgatcttccg agggccgctc gccggaacga ccaagacggt caacggccgg
      901 gcggtcgagg tcgagggtgt gctgagcagg aacaacttcc gacgggtgtg ggttcctgcc
      961 atccaagagg ccggcatcgc gcgtgaggtg aagaaccccg agaccggccg caaggagtgg
     1021 tggccgaggg tctcggatta ccgggacgcg tacgcctcgc ggttgcacgc gcaagggctg
     1081 tccgaggtcg acgtgcagta catcctcggg cacgaccgcg gcggcaaggt cacgtggctg
     1141 tacacccacc gcggcgagga agctgtcgag aacgctcgca aggcactcgc cggtggccgc
     1201 cacctgcggg ccgtctcatg aggccgggaa gggacagagt ccacatggag tccacaaacc
     1261 cccctcggcg tccctcgctg cccctctttt tctctcggta agagcagatg ttgatcaaga
     1321 gggctgccgc tgaccagcac tcggaacgcc tcggagtggc tcggcgaaac tcgccgggcg
     1381 gtacatctga ctttgcatgg cagatgtcag gggttcgact cccctaggct ccacaccgga
     1441 agagcccctc ggtctgcggg aacgcaggtc gaggggctct ttgcgctcgt cgcggcgccg
     1501 ccgtcccgga gtgccggatg cttccgcgac tcggtgaacg gtacggaggg cacggcccgc
     1561 gggatcagcc gccgacgacc gcgcggagcg tcacgtacag cagcgacggg ccgaggaggc
     1621 agccgatgcc cgtgtagaag gtggccgtca tggcgccgta ggggaccagg cgcttgtcgg
     1681 tggccgccag gccgccggcc acccccgagg tggtgcccag caggccgccg aaggccatcg
     1741 ccgacttcgg gttgttcagg ccgatgagcg gggcgatcag tggcgttccg accatcacca
     1801 ccacggactt caccagtccc gcggcgacgg acagcgctat cacgtccgag ctcgccccca
     1861 ctgccgtacc ggtcacgggg ccgacgatgt aggtggcggc cccggagccg atcgtcgcca
     1921 gggacgcggc gtccgtgtag ccgaagaggg cggcgatgac cacgccgacg acgaacgaga
     1981 gcaccacgcc cagcacgatc gacagcgcgc cggagagtcc ggcccgcttg atctccttga
     2041 ggtcgacgcc gtacgcggtg gagacgatgg cgaagtcccg cagcatcgcg ccgcccatca
     2101 ggccgagccc ggagaagacg gcgaagtcgg cgatcccttt ctcgccgccc gtcacggtgc
     2161 cgccccagta ggcgagtacc aggccgagca ggatggcgac ggcggagccg tgcagacgac
     2221 cgcggctcag cttcttcgac agccaaccgg agaccagcat caggccgccg acgagtgcga
     2281 aggccacgac caggtcgttc tcctcgaaga cggagacgag cgtgtccacc tcagacctcc
     2341 tgcttctcgt cggcgtcctg cggcggcagc ggctcggccg ggctgcctat tcgcgccagt
     2401 accggtacga gcgccgctcc ggccacgacg gcgccgagcc cggcgaggat cgccatcggc
     2461 ccgccggcga tcgcgccggc cacgtcctgg gttgcggcca tggcgacgac gatcgggatg
     2521 tacatcgccg accagaagag caccccctgc tcggtcggct cggggaactt gcctctgccg
     2581 cggagccagt gggagacgag caccagcatg atcatggcga agccgactcc gcccacgttg
     2641 gcgtcgaccc cgacggcgat accgagcact tcgccgacga gcgtgcccgc cagcatgcac
     2701 accgcgagcg ctgccactcc atagagaacc atcgtcttct ccacactgag agacttcaga
     2761 ggatgagggc ccacgaggcc cggttctgct tgttcttcgc ctcgctcgcg tctccctcgt
     2821 gggggcgtga gcggtgtcct gctgtccgtg gggaggtcgc gtccccgacg tcgtgccgtt
     2881 ccgctcgccg ggtcaggtgt ccgcagggga cgccgggggc gtgaacaggg attcgtagcg
     2941 cttgcgcagt tcggccttct gcaccttgcc catgacgttg cgcggcagtg cttcgacgac
     3001 gcgtaccgcc cgcggatgct tgaaccgcgc caggtcgccg gcgacgaact cgcgaagttc
     3061 ctcggcggcg ggctgcgcac cgggcgtggg gacgacgacg gcgacgaccg tctcgccgaa
     3121 gtccgggtgg ggcacgccga tcacggcgga ctccaccacc tcgggatggg cgtcgagcaa
     3181 ctcctcgatc tccttggggt agacgttgta tcccccggtg atcaccaggt ccttgccgcg
     3241 gccgacgagg cacaggtagc cgtcctcgtc gatgcggccg aggtcgccgg tgacgaagaa
     3301 gccgtccgcg cggaactcgg cggcggtctt ctcggggagg cgccagtaac cggtgaagac
     3361 gttcgggccg cggacctcga tgctgcccac ttcgccgtcg ggcagcggct ctccgctctc
     3421 ggcgtccacc acgcggatct ccgtgccggg gagcggcttg ccgacggtgc cgggcttgcg
     3481 cggcccgccc tcgtacgggt tggtggtgtt cattcccgtc tcggtcatgc cgtaccgctc
     3541 gaggatcgcg tggccggtac gggtcgcgaa gctctcgtgg tcgccggcga ggaggggcgc
     3601 ggaaccggag acgaagagcc gcattccggc gcaggtctcc gcggtgagcc ccgggtgctt
     3661 gagcagacgg gtgtagaagg tgggtacgcc catcagcacc gtggcccggg gcagcaggtc
     3721 gacgatcgcg tcggcgtcga acttcggcag gtagtgcagg gaggcaccgg ccgtgagggc
     3781 catgttcgcg gcgacgaaga gcccgtggat gtggaagatc ggcagggcgt ggatgaggcg
     3841 gtcgtcggcg gtgaaccgcc aggagtcgag cagcgcacgg cagttggcgg cgaggttgcc
     3901 gtgggtgagc acggctccct tggagcgccc ggtggtgccc gaggtgtaga ggatcgctgc
     3961 ggggtcgtcg gccgatgcct cgtacgtctc cgtacggcgg gcgtcgtcgt cgaggaggct
     4021 gccgtcgccg gagacgccca gtgtctcgat gacgaggccc tcttgtgcac gccgggtgtg
     4081 ctccgtctcg cgctccgggg cgcacaccag cacgcggggt tgggcgtcgc cgaggaagta
     4141 cccggtctcg ttgccggtgt aagcggtgtt gaggggcagg aagacaccgc ccacctgcag
     4201 ggtggccaga tacagtgcga tcgcctccgg cgacttgtgc acctgggccg cgactcggtc
     4261 ccccggcgcg acgccgtcgg cgacgagtcg ggccgctatg cgctggaccg tctccgcggt
     4321 cttgcggtag gtgacgcccc gcccgtcggg cagctcgaag agtgccttgt ccggccgccg
     4381 ttccgcctgt tcgacgaagg accggtggat ggtggtgaag ggtgacatca gggcgttcct
     4441 ttctcgctcc ccggttctga cgcgtggggt cgcgggggct cggtctccgg gaggacgtcc
     4501 tgcaacgggc cgccgagcgc gaccgtgcgg cggcggacga agtcctcgtg ctgacgctcc
     4561 aaccggtccg gttcgtagcg gtagttgacc atcgcgccgt acgactgttc ccacgcctcg
     4621 ggcgaggtgt tcgccggcca gttcagcttc caggcggtgg cgccgttgcc gaggtggaac
     4681 cgggcgaccg cgtcgacggg gcggccgtcc tcgcgacgtt cgcgcgcgat gtaccgggcg
     4741 aggaccggca gcagcattga gcgcatccgt tccaggtcgg gcggggtgag ggcgcgggtt
     4801 cccgctgacg cctccaactc cgcggcgagc cgttcgagtt cgggttcgtg ctcggcgtgc
     4861 ttcagcagcc agcggcggaa cccggggatc ggcgagagcg tggcgaactg cgtgaggtgc
     4921 gggagttgct cccccacctg ctcgatgacc tgcttgatga ggaagctgcc gaaggagacg
     4981 ccggcgagcc cgtccagcgc gttgttgatc gagtacaggg ccgcggtgtc cgcgctcgcg
     5041 gggtcgatct ccgggcccgg gtcgagcaac ggggcgatgt gctggggcag tccgcgtacc
     5101 agcgcgacct cgacgaagac cagcggcacg tcgccggtcg ccgggtggaa gaaggcgaag
     5161 atgcggcggt ccgccggttg caggcggcgc ctgagctcct cgtggtcggc catcgggtgg
     5221 acccgctcgt gctggagcag gtgggcgtgg aggtcggggg gcgagtcggt ggtgacctcg
     5281 gccatgcgga ggaagccgcg gttgaaccag gaggtgagca agtggaggaa gtcgtggtcc
     5341 agcgggcgga gttcggggtg atcgtgcatc agccggcgca ggtccgcgcg catgtcgacg
     5401 agcgcgggcg tcgcgtcggg ggcgtggttc atgcgccgga ggagctgctg gcgggcgggc
     5461 tcgacgacgt cgaagagatg gacgagttcg gcctccccgt gcaagccggc ctgcctggcg
     5521 ctctcccacc ggtggaaggc ggcgcggacc tggtcggcgt cgacgtcgta ggtacgggtg
     5581 acgtgggcga agaaggtccg tcggccgtcg tcgtcgagtg cggcgtaggc ggcgagggcg
     5641 cgcgctgcta ccgcgcgcat cgacgcctcg ccgacgtcgc tcatcaacac ctcgcatgcg
     5701 acgaggagtt gttcaagcgc ggagtccggc tcgccgggct cgggtgcgcc gtcgcgccgt
     5761 cgtccgagag cctggaacag gtcggccagc agccaaccgt cgtgctgttc catcgccggt
     5821 cctctccctg tcctcgaccg cacaggtctg tgcatacatc agcggttgtg atgtatataa
     5881 ctgcggcacc gtagaacacg tgagtcggat cttccacccc tgggagccgg ataacctggg
     5941 cgttcggagg tgcacatggc gcgagtaccg gaagccgaac gtgtgcggga cgcgctcgag
     6001 aacgccgtca tcaacggtcg ctaccgtccc ggtgagaggc tcgatcccgc cctgttggag
     6061 cgggagttcg gctgttcccg caccccggtc cgggaggcgc tccagacgtt gcagcgctcc
     6121 gggctcgtcc ggatccgtcc caagcagggc acctacgtca cggagctgag cgtctccgaa
     6181 ctaggggaac gcttcgaggt gatggccgag ttggagggga tggcggcgcg gctctccgcc
     6241 cgccgtatcg cccaggaggc cctcgacgac ctcgcgcgca cgctgcacga gtgcgccgaa
     6301 cacgcggcgg ccggcgacgc ggaccggtac tactacgcca acgcccggtt ccacgacgtc
     6361 gtctacgact cctgcggcaa cgagtacctg cgcgagcagg cgcaggcgct caagcgaata
     6421 cttcagccgt accggcggtt gcagttgcgc gtgcccgatc ggatgcgccg ctcgctcggg
     6481 gagcaccggg agatcgctgc ggccattagg gcaggggacg cggaggctgc cgaggacgcc
     6541 gctcgggacc atgtgctcgt gcaggtgaag gagttcagcc agctcgtgca cacctggaag
     6601 cacctcaccg agccggtggg gcgagtggag tgaggggcga gttcgcaggg ggagccgtga
     6661 cgctggggtg cgggggcggt gcggcttcgg tcggcgggca gccgttcgca gtggcgaggt
     6721 tcgtggggtg agcggtgggt gtggcgctca ccggccttcc agtcaaccgg tgcgggcgtc
     6781 aggtctgttg gtcggcgggc atgtgggggc ttttctgggg cttttgcgcg tcaggcgggc
     6841 gtagggctgg gagttggtcc gttcggcagg cggattttgc gatcgtcgac gttcgcttgc
     6901 tccaggaatt gagcggtgca ggtcccgccg gcgcggcctc ggtcgccggt taccgcaggc
     6961 agcgggcgag ggccgcggct tcaccgacca agggatgggc ggcgagtccg gccgcctccg
     7021 ctgcgtcgag ggcccggcgc agaagagggg cgtcgcgggc ccgggtgcac aggaccagta
     7081 cggacggcaa gtacgcctgc aatgccgttg gttcgcgtgc ggggtgagcg tcgtcgagcc
     7141 aggacgcgag ggcgtcaggg gacgcgggcg gtggagggca cggcgtcgcc gtgtcggtgc
     7201 gcggctgcgg tgggcggggg cgctccagga ggacggcgga ggccagagct gctgccagcg
     7261 tcgtgtggta gcaggtgccg aagaggtacg cgtcggcgcg gttgtgccgc aactcctccc
     7321 atcgggaggg catgtggacg ggactcggca ctgcgccgtc gggtcgctga gcggtgcgga
     7381 gggtgttcca cgcataccgc gaggcggcgg ccgggtcggg ggccccgccg agcgcggttg
     7441 tgcacaggag gagctcggag acgaggtcga ggctgccgcg ggcgaggtgc acacccagca
     7501 gcgtgcggac gcactggcgc agtcgggccg ggtggtgctc cgctgcgggt gggcccgtcg
     7561 tggcgccgaa gtccgttgtg tagaagagga catgggtgag cgcgtacgtc tcgtcgtcgt
     7621 cgaggtggag gacgtgcggg cactgcgcgg cgagggtctg cgcgtacagc tccgccggcg
     7681 tggggagggc cggtggggcg gtgaatccgc cgcggtcgag gaagtagcgg agctccaggc
     7741 ggttgagtac gggcttgtag ggcaggtggt ggccgcccgc gcccgccgcg acgagcgact
     7801 gcgccgccgc gtgcaactcc ggttggggcc gaccgagcgt gccgagaagg cccacgaggt
     7861 tgacgtggta cggcagcagc gcgtcggcgc gacggagacc ggtcgcgaac tcgtcctcgg
     7921 caacggcctc ttccgcgaga tcgagcgctc ggcgggccag cgcctctccc ccggtgagag
     7981 cgcggctgcg ccggaggacg cggacgaggg cgagaagttc gaggagcggt ccgggtcgga
     8041 acggccgagc cggcagcaac tcctcccacc gctgcggacg aaaccactcc gcataccgct
     8101 ccagccagct cagagcccgt gtcaacacct cgacggcgca ttcccgctcc gtgcgctgcg
     8161 ccgagaacga acccgcgtgg gaagggagtt gcggccacga ggcgtgcggc ggcgccgtca
     8221 cttgccgctc ctcgtccgca acaggatgag gacgccgcaa aggatcgcac ccagcgccgc
     8281 gagatcggcc caccagacca gcaggccgtg cccgccgagg agggtctgcc tggcgaggtc
     8341 cacggcgtac gtcatcggat tgaggtgcat caccgccgcg agccagacgg gggcgtccgc
     8401 cgcgctgaag accgagcccg agaggaagag catgggaaac atggcgagtt gcaccgtcgc
     8461 ctggagggtc tgcatttgct tgatcaccgt ggcgaggcag aggccgatga cgctgaagac
     8521 ggtcgcggcg agcgcgtagc accccaccgc ggcggcgtac cgcaccggtg tcagctccag
     8581 ccccatcaaa ggtgcgaagg cgagcatcag cgcgctctgc accgtgacca tcccggcccc
     8641 ggctacgacc ttgccgagcg gcaggcagat ccgcggcacg ggcgcgacga ggagctccct
     8701 gagcacaccg aactcccggt cccaggcgta ggtctggccg gaggcgacac cgatggagac
     8761 gacctggatg gcgacgatgc cgggaaagac gtacgcactg aacggcacac cgcccacgct
     8821 tccgatcatg ccgtcgaagc cgaccgcgta gacgaggacg aagaagagga tctgcacgcc
     8881 ctggctgagg agcaccccgg ggcgtttgac ctggcgcagc aggtcacggt gggcgatcac
     8941 ggcgacggcc cggagcgaga cggagaggac ggtctcctcg gcgggcgccg gtgcggtggt
     9001 ggcggtcatc gggggctcgc actctcctgt ccggccgcgg cgaggtagac gtcgttgagg
     9061 gaggggtggc gcactgagac ggtgagcccg ggaacatcga ggacgcggac cacctcggcg
     9121 atcctcgcct ccggttccgc gcagtgcacc gcgaggccgc ccgcctcgct gagcgtgggg
     9181 aacccggctg cgcgcaactg ccgttcggcg gtgccgtggt cggcggggtc cgcgcaggag
     9241 acgaggatgc gggaggatgc gagtccgtcc ttgagctctt ccggaccgcc gcgcctgacg
     9301 acgctgccct gctggaggat gacgatctcg tcggcgtact cggcctcgtc catgtagtgc
     9361 gtggagtaga ggacggtgac gccgagttcg gtgcgcagcc tcagcaggtc cgtccacacg
     9421 gtgctgcggg cactggggtc gaggccgttg gtgggctcgt cgaggatgat caggccgggg
     9481 cggtgcagca gggcgcgggc gatctccaac cggcgggaga ggccgccgga gagctgctcg
     9541 accggttggc ggcggcggtc cgcgagatcg aagaggccga gcaggagggc gatcctggac
     9601 cgggcgtcgg agcgcgtcat cccgaagagg cgggcgtgga accagagatt gcgctcgacc
     9661 gaaagctcct tgtcgagcgt gcgctcctgg aagacgaggc cgagccgcct ccgtgcggcc
     9721 atcggcgcgg cgccgacgtc gtgcccgaag atgcggaccc ggcccgcgtc ggggcgggag
     9781 gccgtggaga ggaccccgag gagactggac ttgcccgcgc cgttggggcc gaggagtgcg
     9841 gtgatgcgcc ccggcggcga atcgacggag acaccggcga cggctgtcac cttcccgtag
     9901 cggacgacga ggtccgcgac ctcgaacgcc ggtgctgcct ccactgcttc ctccttctcg
     9961 ccagtcggaa cccccggctc ggacaccgct gcctgccccc tcacgccagc cccaggcagc
    10021 ggtcccaggc gagcggggac gtgttcggag gaaggagcgc gagcgccacc cccgccgcgc
    10081 cctccagcaa ccccgccacg ttcaacgcgc ggtgcggatc gggagagcgg gccgcggccg
    10141 ggtggcgcat gaggtggcgg aagccgaacg gcgccgactc gtcggcgagt tcgaggaccc
    10201 ggcggcgtac gggctcggcg cgggcggcga gctctgcgtt gccggcctcg tccgccacgc
    10261 gcaggacgat gcggaggaga cccgcgaacc cgtggcagag agtcgggccc tcgatcgccc
    10321 acctcgacgg gtcgcgccgc agggccgtct ccaacgcggt gaccgctgcg cgacaccacg
    10381 gccgctcgcc gagcgcacac ccggcgcggt ggagcgcggc cgcgacgccc ggagtgccgt
    10441 agcaccaggc ggtacgggtg aagagcgccg aagggcgctt cgacctggat gccgtctcgt
    10501 cctcgcgagg cacacgggca ggccagtagg ggccggcgtc gtcgtggagc gtccagccga
    10561 ggagccactc ggcgatgcgg cgcacggcgt cgcgcgtgcc ggggacctcg cgcccggcgg
    10621 tgcaggatgc ggcgaggacc gagagagggc ccgcaatgcc gtgcgccata ccgaggttga
    10681 ggtcgccgcg cggataggtc cggcgatcac ggtcgctgac ctggagctcg gccgggaccc
    10741 accagccggg gagcacgtca gagtcgacgt ggaccggctc ggtgagacgg acgaggtggc
    10801 gcagcgaggc gtcgagcgcc gactcgacct ccgggctcac ctccgccggg tccgtcgcgg
    10861 agtcgaggag cagtctcgcc gtccccgaga tgccgttcac gaggtcgtag gcgccccagc
    10921 cgacgccggg tgtgcgggcg cgggcgtcga aggcgcgcag ccttgtcgcc tggtcgtcgg
    10981 cgacccagcg ggcgaggcgc gaacgcagcg tggcgtaatg accgtcgagg cctgcgcagg
    11041 tctgggcggc ggccaacaac gaggcaggac cggagaagag gccgtgactc ggcgacgtcg
    11101 ccatcgcacc ggcggcggcc tggaggtggc ggtgtgccac ggtgcgccac cgctcgtcgg
    11161 tgcgggtgag ctcgccgtag aggagcgcgg tgccggggag cccgttggcg agcgtcatcg
    11221 ggccccacat gacggcgtcg tagaccgggt cgcggttgtc gtccctggag gccacggcag
    11281 cggtgtgcgc gggatcggcg aggcgctcgg cgacgaggga gaccgcctcc gccgcgctga
    11341 cggtgcaggt ccgcttcatg cgtggtgcct ccgacggttg aggttgtcct ggacggctcc
    11401 gcgtgcgatg ccgagcaccc tcgcctcctg ggcgctgtcc ccgccgaaga ggcggttgca
    11461 ggtcatgtgg aggaggctgc cgactatgcg gccccgcggc gtcgacgacg cctcgcgaac
    11521 acgcgaggcg agccgccgca ctgcctcgtc gcgcggcagc agggcctcgc gtatccgcag
    11581 ccccgtgccg tcgccggcga gcgcggggaa gccggcgtac gggtcgacca ggcgtcgcca
    11641 ctgcccggcg cccggccggt actcctgggg aaggtcccgg cgagagcccg tcatggagag
    11701 ccatgccgca gccgagtcgt ccccgaagtc gcccgtgagg agcgggtctt cggggtccgg
    11761 tgggccgaag gcgtgagcga gggaggcgac ggagacggcg gcgaggctct ccgcgtcgtg
    11821 gccgttctcc ggctccttgg cgaggcggag cagttccagc gccgcctcgc tgtcgtaccg
    11881 gaagacctgc tcggcgaggt gttgcgccgt ggggcctccg taccgttccg tttccgggtc
    11941 gtactgcgcc agcgtgtggc tgcggacgag accggcgcgc tgccactcct cgagcagggc
    12001 gccgacggcc ggtgccaccc gtccccacag gcggtcggcg gattccgcgt aaaggcgtac
    12061 acgcaggtgg tgccctgacg ggtcggtgta gcggaggaag aaccagctct cggctccctc
    12121 ctcgccggcg aggttgacga gcgcgggcag gtggtcgcgg aggagttcgt cctggcagcg
    12181 ggcggggccg tggagcttga ggtagagcca gttgccgccg agcccgtgca cggtgcgctg
    12241 cggctggtgg tgccccgcgt acccgcgccg cggggggacg tcggggcggc gggtgagcgg
    12301 gacgaccaac tccgtcgtgt gtccggcgaa agggctttcc aaccaaccct cgtgctctcc
    12361 cgggacctcc tgcgcgatca gttccgggtt gcggcagagc tggtcgcgga ggagctcgcg
    12421 gtgccaggca tcgtcgaggt cgagcgtgag tcgctggtcg gctgcgacgg cgaggacgag
    12481 ccgcggcacc tgccagaact cctgccaccg cgagagggcc gcctcccagc ccgcgtgcga
    12541 ctcctcggct gccgcccgca gttcgtcgag ccgccagacg gcgctggcga ggacgaagcg
    12601 gccgtggcgg acgcgcggca cgaacggcgc gtcggcgagc ggcccccagt tccacggctc
    12661 ccacagccgc tggccctcga gcccgatctc ccacaacagc cgtaccgcgt tgggcgcttg
    12721 ggccggcgcg ctgaccatgt tgcccagaac gggagcgagt tcgcggcccg tcggcagatg
    12781 gaccgccgtc atccgctcca atgtcgcgcc gataccgacc tccgccaccg gcagctcctc
    12841 gacgtccccc gcgttcggca cgccgaccga gacccgcctc ccggtgccgg ggaccgtgtg
    12901 cgcgaggttg gcggcccgcc caccgcgcgg ccggaaggcg aggtccacgg ggacggcgcc
    12961 cgccacatgt gtggggacgt cacggtcgag cgcggcgaag cgggcccgcc actccgggtc
    13021 gaggtcagcg aagcgtgcga aagtcgaccc ggcacggtgg gagcccggtg agggggagag
    13081 gaagacgcgg aactcgcctt cgccgagcgc ctcggccccc ggcgccgtca cctggacggt
    13141 gacctcgcac gaggagggca ggtcggcagg gtccgccgag ccgcgcgcga actctgccaa
    13201 ctcggcgtcg ctcagcacga cttcgcgaag cccggcccgt tgggcacggg cgacgaggcg
    13261 ggccatcgcg cggtccctgc cgagcgaacg cgcgtcctcg ggcggtactt cgggggcctc
    13321 gctgttgggc cagccgtacc cggcaggggc accgaggccc gtcgcctcgt cgaggagctc
    13381 cagcacgggg acgagacggt cggcgccgta gacgtcgagg aagcggcggt ggtactcgcg
    13441 gagggcgaag aggccgagct tggggcggga gaggcgccac atcacctcgg cggcgcgctc
    13501 gacctcggag cggacgacgt gcgggagccg cagctcggtg tcgagccgcg tgtcgatgtg
    13561 gagaggagtg tcgtccggct ccgccgcgcg agcggtgtcg aggaggtgcc ggagccggcc
    13621 cgcgccggcg ccgacgggga gcgcgtcgta cgcgtgccgt gcgccgtcga gacggtgcag
    13681 ggcaagccgc agctcctccg tctcctccga tgtcccgcca ccaccggacg cgcggtcgag
    13741 gacgtcgagc aggtgtcgga gcgggtcgcc gccgtcgagc ggcgggcgga cctcggtgat
    13801 cagcaactcc tcccggacca gggcggcgag gagcgtacgc acgcgctcga ccggtacccc
    13861 ggggaacgcc gcggagaggt ccccgacgag ctccccgtag ggcacggggc accgcgcctt
    13921 cgccacggcc tcggcgacga gcggtgtgcg ccgtacggag accgtcgacc tgtcgggtcc
    13981 gtcgccgcgc ggtgggacgc cgcgggtgga cgggtaggtg agcacgaggc ggtcgcctcg
    14041 cacccggagc ccctgatgtg cctggacatc gaggcacgag agcactgccg cgtccgcttc
    14101 cagccggttc cccactctgg tgagccactg catgtcgacg tgcgtgcgcg tccggtgcgc
    14161 cggaccgcgt tccgccttcg ccgtcgagtc gaacgtcccg acggcgaccc ctgcgaagag
    14221 gccgaacggc gtcggacggg tgcgcctgcg tacgtcgtac ctgaggacgg ccagcgccgc
    14281 gcggcgcagg cgtgcgtcgg tgatcccctc cgctccgtgc gcgcggaccc tgtggacgag
    14341 cgaggcgagg ctgggggagg cgaggagcag cgcctcgtgg agtgcggcgt cgtccccggc
    14401 ggacgccagc accgcggcgc acgcctcccg ctcgcgcggt ccgcccgcgt gcccggtggg
    14461 cagcccgggc gcctgcgggt tcagcgggga cctgcacagg aagaggtcgg ccgccctgaa
    14521 gagattgccg ccgtccctgc ggtccgtgtc cgagatgctc ggctccccca tgtctccccc
    14581 tggtcgattg cttctggtgc ccggtcgcgg gcgggtcgtg ccgggaaggg acgtgcggtc
    14641 cctccccggc acgggcgtca gcagcagtgg ctgcagccgg agccgccgcc ctcactggtg
    14701 catcccgggg tgcagtagga gatgctggtg acggccggac cggccaccga cttctccaca
    14761 ccgatctcca ggtcgaggtc gagcagcccc tcgtcgttcc tcacgtcagc gggagagttg
    14821 atacccacat cggcctcctt cgtcgagaac agacaggtgt gcaccggatc gatccgagtt
    14881 atacgcaagc acgtctgtgc ctcccgactc accgggtagc tggggaaatg gcagtgatgg
    14941 caggttcgtg gcaggggcgc acccgagggg cgcgcggcgg aggccgtgcc gcaaccttcc
    15001 tggggaattg cgcagacaac agtgaaccgc gtccgtcggc agcgctacac acaagatgtg
    15061 tgttccgacg agactctgct gaccgctgcc gcgcacggcg accagtcggc cctgcgggac
    15121 ctgtacgaga gacacgctgc cgccatgctg cgcctcatcc gtaggctcac ctcggaccag
    15181 ggcgccgccg aggagatcct ccaggagtcc tggctggccg tctggcgctc cgctacgggt
    15241 ttccgaggcg aatcctccgt gcgtagctgg ctgttgggcg tagcacggcg gcaggcgcac
    15301 aaccagctcc gccgctcccg tccccgcttc gccgacctcg ccgaggcgta cgaggtcccc
    15361 gaccccgccc ccggcgtcga ggaacaggtc gtcgtcgcag ccgagcgcga cgcactgcgc
    15421 acggccgtca gggccctacc ggaacacctg cgcgaagtcc tcgcgctcgt gcttgtcgaa
    15481 gacctggcct acccggaggt ggcggaggtg ctggagatcc ccgtcggtac cgtcaaaagc
    15541 cgcatgtcgc acgcccgcaa gcggctcggc aacatgctcg ccgccacgcg gctggaagga
    15601 acggcgcgac gatgaagcaa ccaccccacc tggaggacga ctccctcgca gccctcgcca
    15661 aatcgaccgc ggacggggcg cgccccgcgc acctgagaga gtgcgccgcc tgccgcagtc
    15721 gcctcgcctg gtggcagggc gtcaccgatg cagtccgtac cgacgaagcg gcgcgcaacg
    15781 cagccgcacc ctccttcgac accctcatcg ccccggtcct caccccgcag accgcgacgc
    15841 aaccccagcc cgtcctgtcg acggcgcccc accgtccgtc acccgcgcgc acgctccgcc
    15901 tcgccggaca actcgtccaa cgccagacga agctgctccc ccgggcgtgg gcaccgctca
    15961 gcgcggtcgg cctcctcgcc gccgctctgc tcgcaccgct cctcggcgac ccgagcacga
    16021 cgctccgcgc cttctccgcc gccgctgtcc tcgtcctcct gctcggcgcc ctcctcgtca
    16081 gctcccccag aaccgacccg agacacgagc tgatgcacac cctcccgacc tcgccgacga
    16141 gcgtcttcct cgcccgcacc acagccgtcc tcaccctcga cctgctactc gcgctcggct
    16201 gctccgcgct cctcggcgac ctcggctggt ggacggccgt ctccggctgg ctcgggcagg
    16261 gcctcctcgc ctccaccgct gcgctcgccc tctccctccg gctcggcgcc gccaccggag
    16321 cctcggccgg tgcggcgatc tggttgctga gcgtcctgac cggacccgac ggcctcctca
    16381 caagccccct cgccgtcgtc ctcaacccgc tcctgacgac ctcctggtgg acgctcgccc
    16441 tctccgcgct cctcctcggc tgggccgtgc gccaggtccg ccgctccccc gacgccgtcg
    16501 ccgaacccgc gtgaaccgcc cgccgcccag ccgctacgta cacgcacgta ccgcctcccg
    16561 tgcccggctc cccccgttac cggcagggga ggcggtacct cccaccagcc accgaccgcg
    16621 ccgagagggg gcaacagcca tgcgcaccgc atccaacacc gcaccgccgc aggcgtcttg
    16681 ggcccaggaa gctcgtcgct gcgggagaac cgcgctcctg ctgcccgcgc tcgccgccgt
    16741 cgccgcgttc gccgccttct cggcggggcc accggaaggg acccttcccg gacgcctcgt
    16801 gctcgagtgc gccctgcccg tcgcgaccgc actcgcctgc gccaccgtgg tcgtacgcga
    16861 acccatggcc gagctccacc tgacgctgcc caccggctac ccccgcacgg tcacccgccg
    16921 cctggccctc gtcggtgccg cctcggccgt ctccgcgctg ctcctcgtcg caggccttct
    16981 ggccacggga agttccccgg cgcctgccgc gactctctcc gaactcctcg ccctcacggt
    17041 tttgttgagc ggaaccgccg tctggtccgc cgtacgcctc ggctcgggtg ccgccgccac
    17101 cggaacggtc gccgccgtcg tcctggccaa ggtcctcctc ctcgaccagg ccctcccgca
    17161 ggccaccgtc caagcgccct gggcgcttct cgcaggcggc gtcctcttcc tgttcgcgct
    17221 gcgcaccctc gccgacgccg agcgctccgc cctgcgcctg ctggaggtct gatgaacgcg
    17281 ctgctgtgca ccgtgcgcta cgaggcgctc atggcggtac gacgcaaggc ggtcctcggc
    17341 accgtcgtcc cgctcaccgc actcagcctg ctcctcgccg tcacctcgcc cgtcgtcacc
    17401 ggccacaccg acccgacggc ccgcgtcggc gccgtcgtgg tgctggtcaa cactttctgc
    17461 gccctcggcg tcggcatcgc cctcgccgac cggctccgca gaggcatgga gacacgcggc
    17521 ctcgccgacg tgctggaggc gacccccacc gccgctctcg cgcgcagtct cggcgcctcg
    17581 ctcgggccgt tgctcaccgc gctcacgccg gtcgccgcac cccttttgct cttcggcgcc
    17641 gtcgtcgctg ctgccgccgc ctcgatcgtg ccgttggtcg ccaccctcgc cgcgctcgtc
    17701 accgccgtac tcccggccgc gctcctcgcc gcctcgctcg gcgggctgct cggcgcgctg
    17761 atgccggtag cggccgcgcg cggcgtcctc gtcgccgcgt ggctgtgggc cgtccagctc
    17821 ccgccctcgc tctcgcccgt ccccacaccc acgggcaccg tgttcagccc gctcggcgga
    17881 tatccgctcg tggcctgggc ccacgccccg gaggtctggg cacgccgcga gagcaccggc
    17941 ttcgcgcgtc ccgaagtgac cgacacgaca gccctgttga acctggccct cgtgctggcg
    18001 ctcgccctcg cctgctacgc cctcggccac ctcgccaccc gactgcgacg acacggagcg
    18061 ccatgaacat caccacccgc cgactcgcca aggtctaccg cggcggacac cgggcactcg
    18121 acgacgtcga cctccacgtc gaaggcggca ccgtcgggct cctcggtgcc aacggagcgg
    18181 gtaagaccac actcctgcgc gtcctcaccg gcatcctgcg cccgacctcc ggcaccgtcg
    18241 aggtcgccgg gcacgatctc gcgacaaccg cgggccgtac cgcggtgaaa cgcacactcg
    18301 gttaccttcc gcaggagctc tccctctacc cggacctgac ggcacgcgag ttcctcgact
    18361 acatcggcgt gctcaagggg ctcgacgaca agcgcgagcg tcgcagacag gtcgaggaac
    18421 acctcggtga cgtcggcctg gaggacgccg cgggacgccg cctctccggt ttctccggtg
    18481 gcatgaaacg cagagtcggc atcgcccagg ccctcatggg cgaaccgacc gtactcgtcg
    18541 tcgacgaacc gaccacgggc ctcgacccgc acgagcgcat gcggttccgc aggctgctcg
    18601 ccgggctcgg acgggggcgc accgtgcttc tctccaccca catcctcgac gacgtcgcac
    18661 agacctgccg cgaggtcgcc gtactcgatg cggggcggct cctcttccac gacaccacgg
    18721 ccgcgctcgt gagccaggcg gccgggcgca cttgggccgt caccgcgaca gaggtcggcg
    18781 gcggtccgcc tccggaagca gacgtcgtca gcgcggccac gacctcggca ggcgccgagt
    18841 accggatggt tgccgacgcc gccccggccg gcggccgacc agccgaaccc accctggagg
    18901 acggctacgc cgctctcctc cgcgaccacg cccccacccg agctcacgcc acggcaggcc
    18961 acagcacggc ccggtccaca gcagaaccac cttcacacga gaggaagtaa ccacgatgag
    19021 ccccgcggcc ccacccgctg cagctccgcg cgccgaattg cgtacgcaca ccaggcgcca
    19081 cggcgcactt ctcggcgcgg ccctcgccgc gttggtactc gccggcaccg ccggctgcaa
    19141 gggcgaaggg cgcgccgacc cagccaccac cgatccggca ccgttgccga gccccacgag
    19201 cacaaaacag gagatcggcg aagagaactt cgcctacacc tggccgttca ccgtcccccg
    19261 tggcacagcc gagtgccgcg acggtgacaa ggccgtcttc accgtgcagg gaggcacgac
    19321 ctatgcgctc aacgaccgtg cacgccaagc cggttacccg gatgtcgggc ccatccgtgc
    19381 ctcggggagc ggtggcgggg atatcagcct cggcactgtg ctgagccgcg ccctgaagct
    19441 ctgcaacccg tagcgcaggg gacggcgcgg gctctctcgg cctagcgccg gctccccagc
    19501 atggtttcag cccaccggta gaggccgcgg gacaaacctc agggagaacc gtaagcacaa
    19561 cgggggagat ccaacttgtt cgagcaagcg ggctccagga cggagcccgg gcgtcaggtc
    19621 atcgcccacc acgcactccg cgagctactc gactcgcccc acacaccact cggcagactc
    19681 cgggcccagc tccccgacat ccgcttcgtc gcctatcggg acctcgccgc agagacgtca
    19741 gtcctcaccc ggccgttgct gatgccgtcg acgaccgaat tccagaacga ggagttgcgt
    19801 gccgtccgtc tcaaccaggc caccgcactg attgtcgccg tcacgcacga tgtctccggg
    19861 catcaggcat accacgccat acgttcgggc gccgacctcg tcttcaacct tgccaacccc
    19921 agccgggagc agctcgatgc cgtctgcgca cggtgcgtga gccatagttc cgccgtggtc
    19981 ggtctgagtc agcacagccg ttcttcctcc gtcgaggccg ctggtgaagt gcgacccgac
    20041 ggccatcccg gtccgtacga cgaggaattg ttgagactgc tgggcacctc gctgacggtc
    20101 tccgagatcg cccggcgctt ctactgttcc gagcgcacca tgtaccgccg catccgtcac
    20161 ctctacgacg ccttcggtgt ctcccgcaga tcggagctga tggcggcggt ctccagggcc
    20221 aacggacgac cgaacgtcgt tgccgggcgc aatctctcgt ccagcgacgc cagttgacga
    20281 tgcgctcggc cgtgccggcc cccgggatct gctcgactcc gggggctcgt gcacgagcat
    20341 cagcggatgc gtgcgtcggc tgactccaca aggcggaaga agccctgctc gaggtccccg
    20401 tccggtgcga gtccggccaa tgctccctcg taccgcgtac ggccttcgac gaggacctgc
    20461 acccggtcgc atacctgggc aacctccgcg agctggtggc tggcgagaag aacggccacg
    20521 ccctcgtcgg cgagggcccg gatgatgccg cgcatctcct tgatgcctac ggggtccagt
    20581 ccgttcgtcg gctcgtcgag gaggagaagg cgagggcggg cgaggagcgc cacggcgatc
    20641 ccgaggcgcc agcgcatacc gagcgaatac gctccgacgc gcctgccgcc caccccgtcc
    20701 atcttcaccg tctgcagtgc gggggcgatc cattcctccg ggacgccgcg gagccgggcg
    20761 tgcaccttca tcgtctcggc agccgtcaac gtgggccaca gtcccggtac ttcgatgagg
    20821 gctccgacct gcgcgaggga ctcccgaccg acggggcggc cgaagatttc gatcgttccc
    20881 gacgagggcc gctgaagacc cagcatcgcc ttcatcaggg ttgtcttgcc ggcgccgtta
    20941 gggccgagga ggccgtagac ctcccctgtc tccaccgaca gatcgacacc gtcgagggca
    21001 cggtgcgagc cgtagtgctt gtggaggcca cggatggtga gcgccgtacg ctcggtcggc
    21061 gtcgagggcg cggtgtctgt ctgttgtgct ccgggcatct cagatctcct tgcggctcat
    21121 gtggactcgt ccgacgacga tcaggaccgc cgtcagtgca gccgcgagcc cgagcgcgag
    21181 ggggatggct gacggatctc tcaccgggct gtcctcggga aggggaacgc cgttcgggcc
    21241 gatgccggcg agcggcagca cgacgcgcat cggccaggcg aaggggactg cgaaccagaa
    21301 gaccttgtcg gagacgagcg caccgcagag gagcccggcc acaccgattc cgatgctcgg
    21361 tcccatgccc catacgaccg cgcagagcac ggcgagggcc gtcatggaga gcccgaccag
    21421 ccacggcagg tagaccgcgg gcaggaccgt ccccatcgct tcggggaacg cgccggcgag
    21481 ggcggcgccg agcgccagca tgagcagcag gaccgtggag gagacgaagc cgaggacgcc
    21541 gagggctgcg accttgccga cgaagtagcg gccgcgcggg acgccgtacg agagcagcag
    21601 gcgccacgcg tcctggtcgg cccggacgga gagggcggcg gccaggcccg cagtcatcgg
    21661 gacgagcacg ccccagaact ccagggtcac gttctggaag acctcgaacg ttcgccctgc
    21721 cttcgcctcg gaggagccga gcgagccgag gaacagcggc accgtgatga tcacgggggc
    21781 taggaggtgg taccagagga ggaagccgcg gcgatggcgg atgagctccg tgccgacgac
    21841 cgtcaccagc gacggtgcgt cgcgaccgcg tgcaagcggt ggggccgacg tttcgactgt
    21901 catgcgatct cccggggacc ggttcggtgg acggggggta cgtagcgttc cggtggatcg
    21961 cggttcacgc ccgatgtgcg caaaaaatcc gtttccctgt gcgaggcgtc ggcaggactg
    22021 ccaggcgact gccaaagggg ctgccatcgc aggacatggg ggcagcgggg gtgcgagcgt
    22081 caaagcggtg tcgccggccg agtgccggtc ggatgccgtc ttgccccacc taccgggagg
    22141 aatccgtgaa gacgcttcgc aggggaatcg cagcaaccac cgtcgtactc gctctcggcg
    22201 gtctcgtcgc gcccgcggcg gtggccgccg agcaggcagc ggtcgcaccg tccagcagcg
    22261 tggcggtgat gaaaacctgg cacgcgacgg tgcagtgcca gatcgtccgg atcagcgaca
    22321 acaacgccat caggtacgag cgggcggacg gtagcggcaa caccaaggag aaggcgaaaa
    22381 aggccgccga gcgcaacatc cacgtgccca aggggcacta caagcggcac tgcgacgtca
    22441 agcggtactg gtgagctgag gggagttcgt ctccccagcc ggcgcgaggg gtcggctcgc
    22501 gatgcgggtc ggcccctcac cgcggcgggg tgccgttgcg cgcgctacga caacacgacg
    22561 gagctacgcc cgatcggtca ggcacggcat ggcgctgcac cgttcgctct ttgcacctcc
    22621 tcggtcgggg ccgctcctcc cttccctgct tcgacgattg ctgtcgcggc gcttccgatt
    22681 cgccccacgc cggctcatcc agagtggcag cgctcagaag cgttccgccc gactctgccg
    22741 cccacacgcc tcgggttcac cgtagaactc tcctgcgccc gcccccgaac gcgcctcgtc
    22801 cgcctgttgt acctgctccg tctgtccact cgtgaggcac tcgactgctt acggcactgg
    22861 aggctccaac ttcgcgtgcg cgcgacgatg ttcgcggttt tgcctctgct cggcatggca
    22921 ccgacacaca gctctcttct cagtgatcaa cggcgaattg agcgtcggtc tcctctctgc
    22981 cctgttcctt ccactgttcc gtcgtacggt ctcgctcgcc tcgacggccc gaaaagaagt
    23041 acccgcagtc acctgtgcgc ggacgtactc aaacctcgcg gtgtggttgc ggcctggctt
    23101 ttcgtggctg cggttgacgt ctgcttcgac tgagtggtga ggattctcga gtacgtgctt
    23161 ctcccctttc gctgaacaag ttgctgcgcc cacggctggg tgagtcgctg ctgatgctct
    23221 acccccagtt gcagttggcc gtttccgcga tggcggtcca gagccgggcc cggcaggagg
    23281 cagcggcgga gtactgagca gtcgactgaa agggacgacg ccgagctccg accacccgag
    23341 gccgatgggt gctcgcgaaa gccggtcgtc tgaaccggcc gcttttcaaa gggggctcgg
    23401 cgccgtgcgg tcctggcgct gtcacaggag ccccgcaaag tgttccctga gtcgaaggcc
    23461 cgacacggca cccacgagag aggtgatcgg ctccccgttc cgaaagccga tcagcgtcgg
    23521 catggcgagc actgagtagt cggactgcgt acgagggttg gactccacgt ccatggtcag
    23581 gaccttcaag gcgcctgctc gttcggcagc gagttgagtg agcaccggaa gcatcatccg
    23641 acacggagaa caccacgaag cggtgaactc gacgaggacg gggatggggg aagcgatcac
    23701 ttccttctcg aagtcggcgt cggtgacggc gagcaggtcg gctgtggctg tcatcgcttc
    23761 tccttgtggg gaaccgtgag tcggagcgac ggggttgctt gcgcggaccg gttcggtgag
    23821 gacggcggcc cgggaaggct gttgctggtc aacatgcagg caggcacatc gcctttcggt
    23881 tcggacggtg ctgggggttc ctgggcacgg cggagacggt cctcgatctc ctgacgcacg
    23941 gtgtccaacc gagccgtcag cgagtcgagt tcggcgagct tgcttcggta ggcgtcgagc
    24001 gaggccgggc aggcgtctcc ctcggtgtgc ccggcctgca ggcagtcgag aaacggcttc
    24061 gtctcctcca ggccgaagcc gatcttccgc agtacgcgga tctggcggag ttgcagcacc
    24121 gcaacggggt cgtacgtgcg gtggccctgt gcgtcgcgcc gggaagtgag gagtccccgg
    24181 gactcgtagt agcgcagggt gcgcggggtg gtctcggcga ggtgcgccag ttctccgatg
    24241 cgcatcggtc ctccaacagg tgtgatgtgg tgaggtcttc gacgctaggc cttgacgtcc
    24301 acgtcaaggc caaagtctgt ggataaccgg cgagttgtgg gtaagccgct cacctcgagg
    24361 ggtggtccat cggctcggct tgtggataac tgccgtcgag tcgtcgggcc cttctagggt
    24421 cgtcggcatg gaacccagag cgactgtttc gctgccctcg gtgagcacgc ggaccaaggc
    24481 gaccgagcac ggcaagtcac cgcgacgccg cgggacttgc ctgctcgccc ggagccccgg
    24541 tgggacgcgc atgccggagc gtgtgtacgg c
//
