LOCUS       NZ_KB905814            21503 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Streptomyces sulphureus DSM 40104 F603DRAFT_scaffold00002.2, whole
            genome shotgun sequence.
ACCESSION   NZ_KB905814
VERSION     NZ_KB905814.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sulphureus DSM 40104
  ORGANISM  Streptomyces sulphureus DSM 40104
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 892984)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name :: Streptomyces sulphureus DSM 40104
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 40104, ATCC 27468
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R37654
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11971
            Current Finishing Status          :: Level 1: Standard Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Sporulation                       :: Sporulating
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R37654
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000381025.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 01:54:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,193
            CDSs (total)                      :: 6,120
            Genes (coding)                    :: 6,022
            CDSs (with protein)               :: 6,022
            Genes (RNA)                       :: 73
            rRNAs                             :: 6, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 1, 3, 1 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 98
            CDSs (without protein)            :: 98
            Pseudo Genes (ambiguous residues) :: 0 of 98
            Pseudo Genes (frameshifted)       :: 37 of 98
            Pseudo Genes (incomplete)         :: 75 of 98
            Pseudo Genes (internal stop)      :: 11 of 98
            Pseudo Genes (multiple problems)  :: 20 of 98
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:55:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 267515
            Orig. end                         :: 289018
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905814.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405920
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21503
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="3"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..21503
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21503
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11503](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11503)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            124..879
                     /locus_tag="F603_RS0105445"
     CDS             124..879
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354596.1"
                     /locus_tag="F603_RS0105445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_019545002.1"
                     /transl_table=11
                     /translation="MPSQRASDQQKQPKYRQIADYLRAGIMDGTYPSGQPLPSEETLAK
                     QFSVTRPTVRQGIAELRASGLVEVMAGRGGFVRSPHSRPSLTRPRGVRREPDGRYVEAD
                     GIRWTNAEEPTATRTDAPVALADLLRVPPGEPLFTYDVLQTAEGSPLRQLHRTYVPFSV
                     LVGTKFEEEPPPPAPELYEALSALGHELHFTEHVRTRMPLPDQAEALRLPDGVPLLQLL
                     RVTRDSDGRPLALEELHLPGNDLELTYPL"
     gene            1286..2071
                     /locus_tag="F603_RS34990"
     CDS             1286..2071
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024783.4"
                     /locus_tag="F603_RS34990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HNH endonuclease"
                     /protein_id="WP_158678608.1"
                     /transl_table=11
                     /translation="MAISDKSMKILWALSGGCCAICRTELVIPREVEKDDHSVIGEMAH
                     IHPQSPGGPRGNAPFTGNRDHHSNLVLLCGNHHKVVDDQENGWPVERMKKLKADHEAWV
                     TDTLTRQPLSMSVDPSGPDPKTIEFYLVRSGTELWALISSACSFLPSYSEENRTDEEVE
                     QLLVLLDELRDWLELGDTLETLIEQRNARKRMDTILEECANSGYFLYSRKIKMRVAGGT
                     DPIPMTWWQAEVRAVPVEHFFKLVEERLKQRNDESGCSS"
     misc_feature    1676..1678
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2112..3011
                     /locus_tag="F603_RS34995"
     CDS             2112..3011
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F603_RS34995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158678609.1"
                     /transl_table=11
                     /translation="MTSETDAVEHERIVDFNPLRNAADYLDSVFEHLTDKPSQPGARAL
                     KYAILHLQAATEILLKARLIHEHWSLVYRDPKKANLSQFRAGAFDSCSVEAAMDRLAKI
                     AEVPIEQKDREAIASLAKTRNALTHYGHTASAFALESQAAKVLSFLLAFVTKQLVPRLG
                     DDDSWMARKVDDYWLQLADLQAVVEERMKGLSGQLQQHAEYTVWCPDCRQPAFIPGETP
                     TCLFCLQEFDDPENATLDWGYGILGDPDYGPDWFVDNCHCGVENTLVFPVTTVGIGPGE
                     DVALCFACRAVYREEKKR"
     misc_feature    2352..2354
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3133..3441)
                     /locus_tag="F603_RS0105450"
     CDS             complement(3133..3441)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F603_RS0105450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019545003.1"
                     /transl_table=11
                     /translation="MDEVFMTFDALRPRYDHRISMTLTMTAYGPNVYAFSPVYGTSTFI
                     GKGALLLGNPRVALSRSVMMTDERRAYLAKRWAYWQEDERRKNVDANGMVFRETGSE"
     gene            complement(3423..3968)
                     /locus_tag="F603_RS33850"
     CDS             complement(3423..3968)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025448.4"
                     /locus_tag="F603_RS33850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Shedu anti-phage system protein SduA
                     domain-containing protein"
                     /protein_id="WP_078503558.1"
                     /transl_table=11
                     /translation="MVLADWYRLLSQDPEEDEVQRFLELHPSMVPGGSGDIGPGGHHGS
                     DMGAVFRRPKLIGSGRTFEPDFMWVTRSSGLITPILIEIEKPSKRWFKKDERPTSNFTD
                     ARDQLNDWRSWFARGGNQSLFRDTFLCFGDKYHDRPLEPQYVLIYGRELEFKRGGGHTN
                     PTSFDTSEINSGGWTRCS"
     gene            complement(4475..5287)
                     /locus_tag="F603_RS35000"
     CDS             complement(4475..5287)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F603_RS35000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158678610.1"
                     /transl_table=11
                     /translation="MGESHRSPDEPGAQSAKEGLTDDGAIGAAAILLSQRGHTTAAALM
                     LDVTAFIFERRTHYEESMDFTSTLEYEDVILEVEPHLTLGFDRSVVHQIASAFDAVGNK
                     WERYFDEVMVREVIPEVGSDWRNRLARELKGGSVSNQGRNIRYEPTHPQADGLHLTNEW
                     EHKVYQVLRERQSSLPDNETIGIIPLAGTRVLGHTFEPDLMVTYRGRVGVIEIDGPHHK
                     GRRSDDAGRERLLRNAGIRHIDRIDVADSTQKAEVEKFVTDFLKHLSV"
     misc_feature    complement(4817..4819)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(5287..5302)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.36"
                     /tool="antismash"
     gene            complement(5858..6181)
                     /locus_tag="F603_RS0105455"
     CDS             complement(5858..6181)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545004.1"
                     /locus_tag="F603_RS0105455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_245600690.1"
                     /transl_table=11
                     /translation="MTDPKGVCARPADCLTPGVAYVRGWAEGNCAADGLAEVLRAVGLD
                     VDLPGLKADVNVFGDGVVTLGTVRPDAARLLADLLTTALTAEMAWQEDGRPGLGGAADS
                     SAA"
     gene            complement(6205..6507)
                     /locus_tag="F603_RS0105460"
     CDS             complement(6205..6507)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545005.1"
                     /locus_tag="F603_RS0105460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019545005.1"
                     /transl_table=11
                     /translation="MPADHEHSSDSASWSPLDSEEWYAARDAVAGLRDVLIAAGMERDF
                     PYLRADLNAFGHGLIELGRISPETAERLTGLLRRALESTYDVPGTGTHGRQQRND"
     gene            complement(6497..6853)
                     /locus_tag="F603_RS0105465"
     CDS             complement(6497..6853)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F603_RS0105465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_026328167.1"
                     /transl_table=11
                     /translation="MPLGPVMADRASEQIGFFVPTWARDPFDRMVRQESADEAPEYRYL
                     GEGSTVVVPGPMPLTGDRYIWLRAPMRRPEASPSRIAALAAMFVAASSVVARADRYGRE
                     QSAASVEGEATHAS"
     misc_feature    7232..7246
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.44"
                     /tool="antismash"
     gene            7436..8692
                     /locus_tag="F603_RS0105475"
     CDS             7436..8692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354592.1"
                     /locus_tag="F603_RS0105475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019545008.1"
                     /transl_table=11
                     /translation="MKRRIATWENGHSTPDEFYGALICEAFDIAPAELGLSAAVGQDSR
                     LLETRYPPTPEEAFQTVSQLWRADLHGYEPLLLSEASQHAWSEASLRWLVAPDPSFPSS
                     ARTDGARVGLADVAMIKTTSDMFAEMDDRFGGEHARQSVVQYLSQDVAPLLTGQYTEAV
                     GRALFSTVAESTLLAGWMSYDACHHGLAQRYFLQALRLAQDGDDRRLAGSILSAMSHQA
                     TFLGNYTEAATLARAARMGISGVATPTLMAQFHAMEARALARTGDIRACEQALSEATKA
                     LESRNSSDEPEWITYFDEAELAAEAAHCFRDVNSARRAVAHAENAMSGSHVRSDFFATM
                     VLADAHLRAGDPEEACRVALDAFDLGEQLKSARCVSYLKEFRDGLSAVGETAAVRSFRE
                     QANGHRLWTATEGQHDGSR"
     gene            complement(8693..9589)
                     /locus_tag="F603_RS0105480"
     CDS             complement(8693..9589)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019354591.1"
                     /locus_tag="F603_RS0105480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphotransferase family protein"
                     /protein_id="WP_019545009.1"
                     /sec_met_domain="APH (E-value: 7.2e-17, bitscore: 57.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAEFTAESAGAVLGEACRSAGLDPAGAELLRLGSNAVYRLSTAP
                     VIVRIARDTDALDEMQRAVGVARWLETEDFPATRVFGDVEQPAVIGGRVVTYWVNLQDE
                     VEYARLDELADLLKRLHWLEEPKSLGLPHFDPFAKVWDSLRTLDGASEADRSFLEERAG
                     ELNKAYDRLDFVLPFGMIHGDANVGNCLRDRTGRAVLIDLDGFALAPREWDLVLTSLYY
                     ERFGWHTRTEYESFVHHYGFDLMNWPGYPVLADVRELMMTLWLGHQVTTNSRAAEEFPR
                     RVDSIRTGGSRKDWQPY"
     tRNA            9682..9781
                     /anticodon=(pos:277258..277260,aa:Arg,seq:ccg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="F603_RS35005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Arg"
     gene            9682..9781
                     /locus_tag="F603_RS35005"
     misc_feature    complement(9946..9958)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
     gene            complement(10001..10567)
                     /locus_tag="F603_RS33855"
     CDS             complement(10001..10567)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="F603_RS33855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_078503559.1"
                     /sec_met_domain="PF13471 (E-value: 2.2e-18, bitscore: 61.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPVALAPRDRLPPHRRVLPLTAVAAARLLAFVRPSVIRWCLEH
                     ARRGAAPATTGQAPAARQHIVSVSLRCAGQGCLERSLAAALLCRFRGTWPTWCTRVRPH
                     PFAAHAWIEAEGHPAGEPHPPGHRPLLSIAPCPTGPPAPGDETAHGSRRALPLRGGARR
                     WSLPCRRARARVSRASRAPRHCRWQ"
     gene            complement(10564..10854)
                     /locus_tag="F603_RS0105485"
     CDS             complement(10564..10854)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640866.1"
                     /locus_tag="F603_RS0105485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_019545010.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2e-24,
                     bitscore: 81.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 6.7e-15, bitscore: 50.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLRLHPDVSTTALGADDGESRTDEGVVLLNERTGGYWQFNATGA
                     FVLRLLLEGEEPPDIAGRLADHHRVEREQADRDVAAVVEELLDARLLVLDR"
     aSDomain        complement(10576..10797)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_F603_RS0105485_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="7.40E-26"
                     /identifier="RREFam002.1"
                     /label="F603_RS0105485"
                     /locus_tag="F603_RS0105485"
                     /protein_end="93"
                     /protein_start="19"
                     /score="81.0"
                     /tool="antismash"
                     /translation="ESRTDEGVVLLNERTGGYWQFNATGAFVLRLLLEGEEPPDIAGRL
                     ADHHRVEREQADRDVAAVVEELLDARLLV"
     gene            complement(10832..11503)
                     /locus_tag="F603_RS35735"
     CDS             complement(10832..11503)
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="F603_RS35735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_245600691.1"
                     /sec_met_domain="Asn_synthase (E-value: 5e-15, bitscore:
                     51.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVAGPPPHGAARHRRPPPRTGWGLDTVRASESASAAAVETARTA
                     LLRTADEALPLADDPGQHQSLLLLRSTASDHRQLASPFVEEGVHLDSPYLDDRVVEAVL
                     SVRVHERGTPWRYKALLSEAMRGTLPESVRNRATKGEFNAEARSGLLTHRGAILTMCTD
                     SALAERGLLDLDALRRQLHAPHADISAESHVENLVGCEAWLRAVRPPTHPKRTDDAATS
                     P"
     misc_feature    11972..11981
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     misc_feature    complement(12001..12016)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.41"
                     /tool="antismash"
     misc_feature    complement(12084..12097)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.08"
                     /tool="antismash"
     misc_feature    12363..12374
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.57"
                     /tool="antismash"
     gene            12618..12788
                     /locus_tag="F603_RS34620"
     CDS             12618..12788
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004922216.1"
                     /locus_tag="F603_RS34620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF190 domain-containing protein"
                     /protein_id="WP_106431241.1"
                     /transl_table=11
                     /translation="MHIRSILSLSEDLPVAIVVVDSRERVRGFLPQLDELLGEGLVVLD
                     ECEVIRYAAGE"
     gene            complement(12797..14059)
                     /gene="eno"
                     /locus_tag="F603_RS0105505"
     CDS             complement(12797..14059)
                     /EC_number="4.2.1.11"
                     /GO_function="GO:0004634 - phosphopyruvate hydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="eno"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907408.1"
                     /locus_tag="F603_RS0105505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphopyruvate hydratase"
                     /protein_id="WP_019545014.1"
                     /transl_table=11
                     /translation="MLRIARTTALEILDSRSRPTLLVCLTTTDGIRVRAGVPAGASTGS
                     REAVEVRDGDPERFGGQGVRIAAGHVEGEISEALAGRMFSSFREVDQALRELDGTADKS
                     RLGANAVVGVSLAAAKADARSRGMPLWERLAEVGEAEPRMPVPHFNVVNGGAHAQGALD
                     FQEFMVAPRGAGSLPEAVRAGSEIYDHLKSLLSFEGHTTGLGDEGGFAPALGQPEDALD
                     LLVAAITAAGYTPSRQEVALALDPAASELRHDGGYRVGGVQLDADALIERYVDLVRRYP
                     VWSLEDGLGEDDTDGWKRLTERLGGTVQLVGDDNFVTSPTLIAEAIDQGVANAALIKVN
                     QIGTVSEVLDAVRLCRDAGYGCMVSHRSGETTDDFLADLAVGTGCGQLKSGAPARGERL
                     AKYNRLLEISGTAPDLPYGPE"
     gene            14353..15183
                     /locus_tag="F603_RS0105510"
     CDS             14353..15183
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545015.1"
                     /locus_tag="F603_RS0105510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_019545015.1"
                     /transl_table=11
                     /translation="MDAHTELGQDRAHSARMYDYYLGGKTNYRADREAAAGVLRVYPGA
                     LVAARENRGFMHRATRYAAEELGIRQFFDIGTGIPTEPNLYQVAHRFQPDARVVYTDND
                     PIVLAYDRALLTAGPPAAIAYIDADVREPETILERAAETLDFDEPVALSLVALLHFIPR
                     GDDPHRLVARLTERLATGSLLVLSHATTDFDLPDSTHTVAAAARAYEEKGLMLGRVTRE
                     EMGAFFEGLELAAPGLVPTSEWRPDLDLAEGLQRLPGMISPDEVGVWAGVGRKP"
     gene            15385..16872
                     /locus_tag="F603_RS0105515"
     CDS             15385..16872
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907410.1"
                     /locus_tag="F603_RS0105515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_019545016.1"
                     /transl_table=11
                     /translation="MRPRTRPRPRTLLGRTPLAGRYPAAVALALLALCPYLVLTTATTL
                     MEPLLLRELHATRFGLQLANGLSNAAYAFGAVAAADIVQRVPRRHVYLVCEWGFVAGCV
                     LVLCAQGAAVFVTGMVLQGLVTGMLLVAALPPLVTGHGTRRLPTTAAVISLGLFGMATC
                     GPLVGGLVGAFGGWRLLFAVLAVLAVVGVTIGVLAFEPNQPPAQSAAFDWLAIPLALGA
                     TLLPFFGVSWLTKSSFTDPLFLVPVAFGLLLGVGLVAGQYHAPRPLMPVRPISNTLPVA
                     GILGAMTVGAVFTALVELTEGYLVDVAGASPLQVGLLLAPQLPGVVVAALLFRRVLPTA
                     GVPLLALSGLAGVAAAGAVLLTATPSDAAVVVPFAALLLGYGAGAGVAPGLFMAGLSVP
                     STQIGPTFALVELLRSEAAFLVGPVLLRIADAEGLASGFRLAVGASLVLTVLGGALIVG
                     VYLLGGARLHRPDLSAWIAGGSTAYHSPRLGARLRKG"
     gene            complement(16966..17382)
                     /locus_tag="F603_RS0105520"
     CDS             complement(16966..17382)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545017.1"
                     /locus_tag="F603_RS0105520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2267 domain-containing protein"
                     /protein_id="WP_019545017.1"
                     /transl_table=11
                     /translation="MQHDAFIGQVQARAGLSSRGEAEAVTRATLETLAERIQATQAENL
                     ADQLPHEIGEHLRRVAYAQDEPVTGARMDRREFFDRVAQRSGLDPSKAIHAARCVVEVV
                     DEATSGDVLGKIRQSLDEELATVLYAGSSGTAPR"
     gene            complement(17465..17884)
                     /locus_tag="F603_RS0105525"
     CDS             complement(17465..17884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019545018.1"
                     /locus_tag="F603_RS0105525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CBS domain-containing protein"
                     /protein_id="WP_019545018.1"
                     /transl_table=11
                     /translation="MPRTVREIMTEAPVQVSTTAYVSDVAARMRDEDIGAVLVTEAGEP
                     RGLVTDRDLTVRILARGGDVTGIRVREACSRELVSVAPEEPVGGAVELMRGKALRRLPV
                     LDDGQVIGVVSLGDLSVEREPYSALGDISASTPNT"
     misc_feature    18092..18107
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    18097..18106
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     misc_feature    complement(18107..18123)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.38"
                     /tool="antismash"
     gene            18228..18608
                     /locus_tag="F603_RS0105530"
     CDS             18228..18608
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="F603_RS0105530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_019545019.1"
                     /transl_table=11
                     /translation="MESPLEAAIDEWHASVNEGAPERSARAVGRPLVVLGPKGAGPIDP
                     EQFAEWVERSGIKLIPRSWHPVSERLMVVEQDATWPESEGPARVATVFRVTGERVTAAL
                     RLPDLESALELARVCREMAATE"
     gene            18605..19045
                     /locus_tag="F603_RS0105535"
     CDS             18605..19045
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024212.4"
                     /locus_tag="F603_RS0105535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_019545020.1"
                     /transl_table=11
                     /translation="MTAPGPGQILFAFVRHWSRRPPTSEGKLAEQGRLVLVTEAAHSLT
                     QRGIAATVNALAHEIGIDQSGASRLVKSATEAEYLTMQASETDGRRRQASVTASGRALL
                     EQAHRWQEEVFGRLTEDWSEQQRRDFQRAMTDLIDRSYALGT"
     misc_feature    19551..19568
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            19607..20164
                     /locus_tag="F603_RS0105540"
     CDS             19607..20164
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907413.1"
                     /locus_tag="F603_RS0105540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_019545021.1"
                     /transl_table=11
                     /translation="MRDLIVTENITLDGVIEAAGDWFAPANTDGDRSDMAAALQRQAEM
                     ADAFLTGRVTFEEMRSYWPHRAEDGSYVAEYLGRVQKYVFSGTLTHPEWEHTTVLRGTL
                     EAEIRGLKAEPGRDIVATGSISLVHALAAAGVVDEYRLFVHPVVLGTGRRLFPDGAAPR
                     RLRLTETSAFACGVVLLRYRVG"
     gene            20309..20578
                     /locus_tag="F603_RS0105545"
     CDS             20309..20578
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013750.4"
                     /locus_tag="F603_RS0105545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate-binding module family 14 protein"
                     /protein_id="WP_019545022.1"
                     /transl_table=11
                     /translation="MRPRRLATVAALAVAGALLPLPALAAATAFGGPAPVCQENGLFPH
                     AEDARYFHHCSGHRPHLKKCPANLRFDPQLRVCAYAKKANTPRV"
ORIGIN
        1 cagagtggcc acccgtaata cgggttgtca accgtgttgg aatgagagac gctgtcctcg
       61 ttcggagacg atttgtctcc ggatcaagac agcacaggct tgaccagcga ttcggggagt
      121 cagatgccat cgcagagggc cagcgatcag cagaagcagc ccaagtaccg gcagatcgcg
      181 gactacttgc gtgccggcat aatggacggc acctacccat cgggccagcc gctgccctca
      241 gaggaaaccc tggcgaagca gttcagcgtc acgcgcccga ccgtgcgtca gggcatcgca
      301 gagctacgag cctccggctt ggtcgaagtc atggccggcc gaggcggctt cgtccgctcc
      361 ccccacagcc gccccagcct cacccgcccg cgcggcgtac gccgcgagcc agacggccgg
      421 tacgtcgaag ccgacggcat ccgctggacc aacgccgagg aacccacggc cacacgcaca
      481 gacgccccgg tcgctctggc ggacctactc cgcgtgccac cgggcgagcc actgttcacg
      541 tacgacgtgc tccagacggc cgagggcagc ccactccgcc agctccaccg cacgtacgtg
      601 cccttctccg tactggtcgg cacgaagttc gaggaagagc ccccgcctcc cgcaccggaa
      661 ctctacgaag ccctgtcggc cctaggccac gaactccact tcaccgagca cgtccgcacc
      721 cgcatgccac tgccagacca ggcggaagcc ctgcgtctac cggatggcgt cccgctccta
      781 caactcctcc gcgtcacacg ggactccgac ggccgaccgc tcgccctgga ggagctgcac
      841 ctgccaggca acgacttgga gctgacgtac cccctctgag tacgcagagg ctcagacttt
      901 ctctacgtct tcaaggcggc tcgctccgct ccccgcgcgc atgcccggcc ctcggcccgg
      961 cctgtgctca tgtctccgcc cctccagccc ggccagcgcc cgtgccactc catgcataca
     1021 gccacctgat gccagagaag ggggtacgtc gtggctgggg cggtcggctc cacggcttta
     1081 cggagccact ttggcgcgag cctcgaagat catggcccca aagtcgtgct ttaccgagca
     1141 ggtccactac ctgcccgacg cgccggaagc tttcggaacc atgatcactc gcgccaaagc
     1201 agcgccacct caaagccgct ccaccgacct tgcaccttcg ccgacggccc agacagcgga
     1261 acggtgccac agttatgatc cgacggtggc catctcagac aaatccatga agatcctttg
     1321 ggcgctaagc ggcgggtgct gcgctatctg ccggacggaa cttgtgattc cgcgagaagt
     1381 tgagaaggac gaccattccg tcattggaga gatggcacac attcacccgc agtcaccggg
     1441 tgggccgaga gggaacgcac ctttcactgg aaacagagac caccattcga acctggtcct
     1501 actgtgcggg aaccaccata aggtagttga cgatcaggaa aacggatggc ccgtagagag
     1561 gatgaagaag ctcaaggcag atcatgaagc ttgggtcaca gacaccctta cgcgtcagcc
     1621 gctaagcatg agcgttgatc caagtgggcc cgaccctaag acgattgaat tttacttagt
     1681 ccgttcggga acagaactat gggctctcat ctctagtgca tgttcattcc ttcccagcta
     1741 ttccgaagag aatcgaacgg atgaagaagt cgaacaacta cttgtgctgc tagatgaact
     1801 cagggattgg ttggagttgg gtgacactct cgaaactcta atagagcagc gaaatgcgag
     1861 gaagcggatg gatacgatct tggaggagtg tgcgaatagc ggctactttc tgtactcgcg
     1921 caagattaag atgcgcgtcg cagggggaac tgatcctatt ccgatgactt ggtggcaggc
     1981 tgaggtccgt gccgtccccg tagaacattt cttcaagctc gtggaagagc gactgaagca
     2041 gcgaaatgac gaaagcggtt gtagcagcta gtgcatgtat tcgaatccat caacattctg
     2101 aggtgtgagc tttgactagt gaaaccgacg ccgtcgaaca cgagcgaatc gtggatttta
     2161 atcctctgcg gaacgctgct gactacctgg acagcgtctt cgagcacttg acggacaagc
     2221 cgtcacagcc gggagcgcgc gctctcaaat acgcaattct ccatctacaa gccgctaccg
     2281 agatcctttt gaaggcacgc ctgatccatg aacattggag tctcgtctac cgtgacccga
     2341 agaaagcaaa cttaagccag ttccgtgcgg gcgcgtttga cagttgttcc gttgaggcag
     2401 cgatggaccg ccttgcgaag atcgcagagg ttcctatcga gcagaaggac cgcgaggcga
     2461 tcgctagcct ggcgaaaacg cggaatgcac tgactcacta cggacacacg gcatccgcgt
     2521 tcgcgttgga gtctcaagcg gccaaggtac tgtccttcct tttggctttc gtcactaagc
     2581 agctcgtgcc gaggcttggc gatgatgact cttggatggc tcgcaaggtc gacgattatt
     2641 ggctacagct tgctgacctt caggctgtcg ttgaggaacg catgaagggg ctatccggcc
     2701 aactacagca acacgccgag tacacggttt ggtgtcccga ctgtcgccaa cccgctttta
     2761 ttcccggcga aactccgaca tgcctcttct gcttgcaaga gtttgatgac ccagaaaacg
     2821 ccactctcga ttgggggtac ggaatcctcg gagaccctga ctatggcccc gattggttcg
     2881 tagataactg tcattgcggc gtagaaaaca cgctcgtgtt tccggtgacc actgtcggaa
     2941 ttgggcctgg tgaggatgtt gcactttgtt tcgcttgtcg tgctgtctac cgcgaggaaa
     3001 agaagcggta agaggtaaaa gctcgacgag cctcagaaca gacctaatcc ggaataaccg
     3061 agagagggcg tcgcttcata cagtactcct tcgttgtgtt tctcagtatg tctcattcct
     3121 tatgtcatgc ggctactcgc tccccgtctc gcgaaatacc atcccgttgg cgtcgacgtt
     3181 cttccgacgc tcgtcttcct gccagtaggc ccaccgtttg gccaggtaag cgcgccgctc
     3241 gtcggtcatc atgaccgaac gagaaagggc aactcgcgga ttccccagga gtagtgcccc
     3301 ctttccgatg aaggtactcg tcccgtacac cggcgaaaaa gcataaacat tcggtccgta
     3361 tgccgtcatc gtcagcgtca tcgaaatgcg gtgatcgtaa cggggccgca gtgcgtcgaa
     3421 cgtcatgaac acctcgtcca tccgccgctg ttgatctcgc ttgtatcgaa gctcgtcggg
     3481 ttcgtgtggc cacctcctcg cttgaattcc aactcacgac catagatcaa cacgtactgc
     3541 ggctccagcg gtcgatcatg gtacttgtca ccaaagcaca gaaacgtatc tcgaaagaga
     3601 gattggtttc ctccacgagc gaaccaagaa cgccaatcat tcagctgatc gcgagcatcc
     3661 gtgaaattgc tagtgggacg ctcatccttc ttaaaccatc gcttcgatgg cttctcgatc
     3721 tcaatgagga tcggcgtgat aagaccggaa gaccttgtga cccacatgaa gtcaggttca
     3781 aatgtacggc cgctaccgat tagcttgggc cgccggaaca ccgcccccat atcggaccca
     3841 tgatgtccac ccggaccaat atcaccgcta cctcccggaa ccattgatgg atgcagctca
     3901 aggaaacgtt gaacttcatc ctcctcagga tcctggctaa ggagcctgta ccagtcggca
     3961 agcaccatgt ctgagtacgt ctcccaggca tggctcctcg ggcggagcgg atcggtatcc
     4021 ggaacgaccg caccacggac agctctggcg gatgactgag aattctccac aggctaaggc
     4081 tactcagtgc ccgcaaccgt caccctcact tcacggagaa taggtgactg ttgagacgtc
     4141 agcgcttcct gccgaggcca ggtaaccccc cgctaactgg acgtacgctg gtcgacggct
     4201 cgtcgacggc tcgtcgaagt tcttcaggat atgctggcgc ttggcgagag cctagcggcg
     4261 gtaggctcag cggttcgccg ccttgagggg gcaatacgac gctcccggac gctgggcaag
     4321 cgaggacctt ccccggcggc tgatgcgagt agaggcgtcc agtccggacg ttaaccttgg
     4381 ttacccttcc acagccgtcg cattcgtatc gaatcgaatc cggattgcgc attctgcccc
     4441 ttcaattaac tatgccacga cccattcaac ccaatcagac actcagatgc ttcaagaagt
     4501 cggtcacgaa tttttccact tccgctttct gggtcgaatc ggcaacatcg attcgatcaa
     4561 tatgtctgat gcctgcattt ctcagcaacc gctcgcgacc agcatcgtcg gacctacggc
     4621 ccttatggtg cggtccgtcg atctcgatga ctccgacgcg accccggtag gtaaccatca
     4681 gatctggctc gaatgtgtgc cccagaacac gcgttcctgc aagtgggatg attccgatgg
     4741 tctcgttgtc cgggaggctt gactggcgct ctcgaagtac ttggtaaacc ttgtgttccc
     4801 actcattcgt tagatgtaag ccgtcagctt gaggatgtgt cggctcgtag cgaatattcc
     4861 gcccctgatt acttacgctt ccgcctttca gttcacgagc aagcctgttc cgccaatccg
     4921 agccaacttc aggtatgacc tcacgaacca tcacttcgtc gaagtaccgc tcccatttat
     4981 tccccacggc atcaaaggcg gaagcgatct ggtggactac tgaccggtcg aagccgagag
     5041 tgaggtgagg ttcgacctcc aggattacat cctcgtattc gagtgtggag gtaaagtcca
     5101 tgctctcttc gtaatgcgta cgtcgctcga agatgaaggc cgtcacgtcg agcatgagcg
     5161 cagcagccgt ggtgtggccc cgttgcgaca acaggattgc tgcggcgccg atcgctccgt
     5221 catccgtgag tccctccttg gcagactggg ctcctggctc gtctggcgag cggtgcgatt
     5281 cacccatgtg agcatgttga catcggtcgc gggcaattgc acctgatgcg aaagatgttg
     5341 gctgcccgca gtgcgtgata gacggcgtcg gcaagcgggc ttcacgccgc cgcccgtcag
     5401 cccatctcgt tcatcgccgc aggtaaggca accacaagac ggatcggagg ttccctcacc
     5461 gttctcacac tccgggggca agccagcagg ggccgctgac agcggcctgg cagccgggag
     5521 ttgcggtaca gcagcgaggt acagcaacca ccaccactgc acctgttgga ctgcaggccg
     5581 agacttcggg cgaagaggtc cgtgccaggc ccgtgccaga acctgcgggg aaccacgagg
     5641 aacacagggg tatcagccga ccacccacca ggcgccggca ccgctccgtc gcaggtcagc
     5701 cccggagcga gccccaaatg cccttagctt cccaagctca cagctcagcc gacacatagg
     5761 tggctcgtcg ttcggctcgg gctgcggcgc tggggcgccg gtcccagccg acgacgagcc
     5821 acctgtactg cttggcaagc ttgttcgccg atccgttcta tgccgctgaa ctgtcagcag
     5881 cgcctccgag tcccggccgg ccgtcttctt gccatgccat ctctgccgtc agcgcagtcg
     5941 tcagcaagtc ggccaggagc cgcgcagcgt ccggacgtac cgtgccaagg gtgacgacgc
     6001 cgtccccgaa gacgttcacg tccgccttga gccccggcag gtccacatcc aggccgaccg
     6061 cgcgtagcac ctcggcaagg ccgtcagcag cgcagttgcc ttccgcccag ccgcggacat
     6121 aggccacacc tggagtgagg caatccgcag gtcgcgcgca cacgcccttg gggtccgtca
     6181 cgtcgtccac ctcatccgct ctgctcagtc gttccgctgc tggcggccgt gcgttcctgt
     6241 gcccggcacg tcgtacgtgc tctctagtgc ccgccgcagc agccctgtca gccgctcggc
     6301 cgtctccggc gagatgcggc cgagttcgat caggccgtgt ccgaaggcgt tcaggtcggc
     6361 acgcaggtac gggaagtcgc gttccatccc ggcagcgatc aatacgtccc gaagcccggc
     6421 gaccgcgtcc cgcgccgcgt accactcttc gctgtcgagc ggggaccagc tcgcgctgtc
     6481 gctgctgtgt tcgtggtcag ctggcatggg tggcttcccc ttccacggac gcggccgact
     6541 gctcacggcc gtaccggtcc gcccgagcca cgacagacga cgcggcgacg aacatcgcgg
     6601 ccagcgcagc gatgcgcgaa ggggacgcct ccggtcgacg catcggagcc cggagccaga
     6661 tgtagcgatc ccccgtcagc ggcatcggcc cgggtacaac gaccgtggaa ccctcaccca
     6721 ggtagcggta ctcaggcgct tcgtctgccg actcctgccg gaccatgcgg tcgaagggat
     6781 cgcgtgccca ggtggggacg aagaagccga tctgttcgga cgcgcggtcc gccatcacag
     6841 gtcccagcgg catgccgtgg cgctggagtt ggtcgaacgt ctacagcccg acccgctgcc
     6901 cgaccgccac gacgtcgaag aagcgcccag caggaagcgc gtaggggcgt cgagggtcaa
     6961 ccgcccagta ctcccggcac tcgtccgggt catcggatgc gcaggagatc cactgaactc
     7021 cccttcttgt catcatctgc acgtcgagtc acctcagttg gtccaagccc cagccgtttg
     7081 gccgcgttgg aaccaccttc ggccgcaccg ccctgagctg ggcagatgac gagaggtgac
     7141 gggggttgac gtgccctccg gccccgcgtc accccggatc acctgccgat gaacgcaccg
     7201 acctcggaat tacgggcaga caggagggcc ttacattccg taaattcgga ggggtcagca
     7261 ggacagcgca tctggccgga cgcgcgggga ggcgatcaga acggaagcga accggtcctt
     7321 tggggaactc ctccgcgcgg ctcgcaaggc ccgcggctgg ggacagctcc ggctcgtcag
     7381 cgagttacga cggtgcgcga agcgacacgg gaaggcactc ccgtccgatg acagcgtgaa
     7441 gcgccgcatc gcaacctggg agaacgggca cagcacgccc gacgagttct acggggcact
     7501 catctgcgag gcgttcgaca tcgctccggc cgagttgggg ctgagtgccg ccgttggcca
     7561 ggactcccgc ttgctggaga cgcgctaccc gccgaccccg gaggaggcgt ttcagaccgt
     7621 cagccagttg tggcgcgctg acttgcacgg ctacgagccg ctgttgctct ccgaggcgtc
     7681 gcagcatgcg tggagcgaag cgtctttgcg atggctggtc gcaccagatc cctcgttccc
     7741 atcgagcgcc cgcacggatg gtgcacgggt gggactggcc gacgtagcga tgatcaagac
     7801 gaccagtgac atgttcgccg agatggacga ccggttcggc ggcgagcatg cgcgacagtc
     7861 cgtcgtccag tacctcagcc aggatgtggc gcccctactc acgggccagt acacggaagc
     7921 tgtcggccgg gcgctgttct ccacagtcgc ggagtccact ctgctggccg gttggatgtc
     7981 gtacgacgcg tgtcaccacg gccttgctca gcggtacttc ctccaggcgc tccgtctcgc
     8041 ccaggacggc gacgaccgcc ggctggcggg gagcatactg tccgcgatga gccaccaggc
     8101 cacgttcctg ggcaactaca ccgaggccgc gacactcgcc cgagccgcac gcatgggcat
     8161 ctctggcgtg gcgacgccga ccctgatggc gcagttccac gcgatggagg cccgtgccct
     8221 tgcccgtacg ggtgacatcc gcgcgtgcga acaagctctc agcgaggcca ccaaggcgct
     8281 ggagagccgc aacagcagcg acgagccgga gtggatcacc tactttgacg aggccgagct
     8341 ggcagccgag gccgcccact gcttccgcga cgtgaacagc gcccgccgag ccgtggccca
     8401 cgctgagaac gccatgagcg gcagccatgt gagaagcgac ttcttcgcca ccatggtcct
     8461 tgccgacgcc caccttcggg ccggagatcc cgaagaggca tgccgcgtag ccctcgacgc
     8521 ttttgatctt ggagaacagc tcaagtcagc gcgctgtgtc agctacctca aggagttccg
     8581 ggacggcctg tcggcagtgg gagagacagc cgctgttcgt tccttccgcg agcaggcgaa
     8641 tgggcaccgg ctgtggaccg ctacggaggg acagcacgac ggaagccgct gatcagtacg
     8701 gctgccaatc cttccggctg cctccggtcc ggatgctgtc gacccgacgg gggaactctt
     8761 ccgcggccct gctgttcgtc gtcacctggt gcccgagcca caacgtcatc atcagctcac
     8821 gcacgtcagc aagcaccggg tagcccggcc agttcatgag gtcgaatccg tagtgatgca
     8881 cgaaggactc gtactcggtc cgcgtgtgcc agccgaagcg ctcgtagtag agcgaggtga
     8941 ggaccagatc ccactcgcga ggagccagcg cgaagccgtc gaggtcgatg aggacagcgc
     9001 gcccggtccg gtcgcggagg cagttcccga cgttggcgtc tccgtggatc atgccgaagg
     9061 gcaacacgaa gtccagacgg tcatacgcct tgttcagctc tcccgcccgc tcctccagga
     9121 acgaccggtc cgcctccgag gcgccatcca gtgtgcgcag cgagtcccac actttggcga
     9181 acggatcgaa gtgcggcagc ccgagcgact tcggctcttc cagccagtgc agccgcttca
     9241 ggaggtcagc cagctcgtcc aggcgggcgt actcgacttc gtcctgaagg ttcacccagt
     9301 acgtgacgac ccggccaccg atgacggccg gctgttccac gtcgccaaac acgcgcgtgg
     9361 cggggaagtc ctccgtctcc agccagcgtg cgaccccgac agcccgctgc atctcgtcca
     9421 gggcatcggt gtcccgtgcg atacggacga tgacaggggc tgtcgacagc cggtatacgg
     9481 cgttggagcc caggcgcagc agttccgcgc ccgcaggatc gagccccgcc gagcggcacg
     9541 cctcccccag caccgcgccc gccgactcag cagtgaactc cgccgtcatg ctcgcgcctc
     9601 cccgccgcat agatcatgtc gacggtatcg cttcgcagcc gccgcctaca gagcgcccac
     9661 ggcgtatacg cggcgtgacg cacccccagt ccaagtcgat cagcacgtcg acctgcacag
     9721 acgcacacaa gcacgtcggc ctccggagcc gtgtgcgcag gttcgaatcc tgccgggggt
     9781 acttcgagtt cggagtaccg aaacgccccg ccagcagccc agttgccgag tgcggggcgt
     9841 tcgtcgttgg gtgaccagat gcggcggggc gccgccggaa gcagccctat gacggtggtc
     9901 acctgatgac ggcgtagtga tctttgctgc ttcttcgctg gtcagttgcc acatgcgact
     9961 tacagatcgg caccaagcag cgccgggggc tgcctgtcga tcactgccac cggcaatgtc
    10021 gcggcgcacg ggacgcgcga ctgacacgag cccgggcacg gcgacacggc aacgaccagc
    10081 ggcgcgctcc gccccgcagc ggcagcgctc tcctcgaccc gtgcgccgtc tcatctcccg
    10141 gtgccggagg gcccgttggg catggggcga tgctcagcag agggcggtgc ccgggcgggt
    10201 ggggctcgcc ggcggggtgg ccctccgcct cgatccaggc gtgcgcggcg aaggggtggg
    10261 ggcggacgcg cgtgcaccag gtgggccagg ttccgcggaa gcggcagagc agggcggcgg
    10321 cgagggagcg ctccaagcag ccctgtcccg cgcaccggag gctcaccgag acgatgtgct
    10381 gccgggcggc gggggcttgc ccggtggtcg ccggcgcggc tccgcgacgg gcgtgctcga
    10441 ggcaccagcg gatgaccgat ggacggacga aggcgagcaa cctggcagcg gccacggccg
    10501 tcagcggcag cacccggcgg tgcggcggca gtcggtcgcg gggcgcgagg gcgaccggtt
    10561 cgctcatcgg tccagcacca acaaccgggc gtccagcagt tcttcgacca cggccgcgac
    10621 gtcccggtcg gcttgttcgc gctccacccg gtggtggtcc gcgagtcggc ccgcgatgtc
    10681 gggaggctct tcgccctcca gcagcagacg cagcacgaac gcgccggtgg cgttgaactg
    10741 ccagtagccg ccggtgcgct cgttgagcag tacgacgcct tcgtcggtgc gggactcgcc
    10801 gtcgtcggcg ccgagagccg tggtggagac gtcagggtga agtcgcagcg tcatcggtcc
    10861 tcttcgggtg agtgggtggg cggacggcac gcagccacgc ctcgcaaccg acgaggttct
    10921 ccacgtgcga ctcggcgctg atgtcggcgt gcggtgcgtg cagttgccga cggagtgcgt
    10981 cgagatcgag cagaccgcgc tcggcgagcg ccgagtcggt gcacatcgtg agaatggcgc
    11041 ctcggtgcgt cagcagtccg cttcgggcct cggcgttgaa ctctcccttg gtcgcgcggt
    11101 tgcgcacgga ctccgggagg gtgccgcgca tcgcctcgga gagcagcgcc ttgtaccgcc
    11161 acggggtgcc ccgctcgtgg acgcggaccg acaggacggc ctcgaccacg cggtcgtcga
    11221 ggtagggaga gtccaggtgg acgccctcct cgacgaaggg ggaggccaac tggcggtggt
    11281 ccgacgccgt cgagcgcaga aggaggaggg actggtgctg gccggggtcg tcggcgaggg
    11341 gaagcgcctc gtccgcagtg cggagcaggg ccgtgcgcgc cgtctcgacg gcggcggccg
    11401 aggcggactc ggacgcgcgg accgtgtcga gcccccaccc agtacggggc ggcggtcgtc
    11461 ggtgtcgggc ggctccgtga ggcggcgggc ctgcgaccgc caccagctcc atacgctgcc
    11521 gggacgcatc agtcctgcga cggtggcgcc cagcggccac ctggccagcg agcggaacgc
    11581 tcgcacgtac cgcagcgcga ggacggggtg gtgcgacacc aatcggtgcg ggtagccgtg
    11641 ggagggcagg aagagctcgt ccccgccgaa tcccgacagg tgccagtggc agccacgcgc
    11701 cgccagcatc cgggcgatgt gccgcctccg ggcgtcggtg cgcgcgaaga ccgcgggctg
    11761 ctccgtcccg caggcccgct ccggttcggc gaacagctcg ggcaactcct cctgggcgac
    11821 gacgagatgc tcggctccgg aaagtcggcg ggcggcgcgg gtcgcgaaca ccgtgtctgt
    11881 cccggtccgg atcgcccagg gacggccgga gcggtaccgc accacctggt cgccggcccg
    11941 cgggagcaac ctcgccttca tttttctcct ctgatttctg agcgccgcct gcggcacttt
    12001 gtgaaaacag cgtgcagaag aaatacgaaa cccggtagcc cccggaacaa ccttcacccg
    12061 atggaatgac acgcgccacg gaatttcgtt caacaatgca ttctcatatg cctctccgcg
    12121 ctactgcctg cgcaccttcc ccaccacacc cggcaacggg cacctccagc gcaactgcag
    12181 gtaacggagc acacacggga agctacccgg ctcgcgcagc gcacgcccgg ctccccattc
    12241 cggcggctca ccctcggaat gccgggcacg gtggtacgcg ccgacctccg gtacctctat
    12301 tgtttcgtcg ccccgtgtgc acggcgagag cggacccatg gaaattgaca cgaagtcggc
    12361 aggaaaaagt ttccccgaaa acgcagaaga gcaccgggaa aggcgcaccg aatcccgcgc
    12421 ggaaaccgtc gccgaggtcc cccacacacc caaggcaggc gtcccggccg tgaccacaca
    12481 ccgcacgaac cccatgcccg aggcttccgt ggcggagcac acgcggcagg accacggccc
    12541 cgccatcgcg gtacggggac tgaccaaggt ccacggcgag cagcgcgccg tcgacggcgt
    12601 cgacctgacc gtcggctctg cacattcgga gcatcctctc gctgagcgag gacctgccgg
    12661 tggcgatcgt cgtcgtcgac agccgcgagc gggtccgcgg attcctgccg cagctcgacg
    12721 agttgctcgg cgaggggctc gtcgtcctcg acgagtgcga ggtcatccgg tacgcggccg
    12781 gggagtgacc gacggttcat tcgggtccgt acgggaggtc gggggccgtg ccggagatct
    12841 ccaggaggcg gttgtacttc gcgaggcgct cgccgcgggc cggggcgccg gacttgagtt
    12901 ggccgcaacc ggtgccgacg gcgaggtcgg cgaggaagtc gtcggtggtc tcgcccgagc
    12961 ggtgggagac catgcagccg tagccggcgt cgcggcagag ccgtacggcg tcgaggacct
    13021 cgctcaccgt gccgatctgg ttgaccttga tcagcgcggc gttggcgacg ccctggtcga
    13081 tcgcctccgc gatcagcgtc gggctggtga cgaagttgtc gtcgccgacg agctgaacgg
    13141 tgccgccgag gcgctcggtg agccgcttcc acccgtccgt gtcgtcctcg ccgagcccgt
    13201 cctccagcga ccacacgggg tatctgcgga cgaggtcgac gtaccgttcg atcagcgcgt
    13261 ccgcgtccaa ctgcacgccg ccgacgcggt atccgccgtc gtgccggagt tcgctcgccg
    13321 ccgggtcgag tgccagcgcg acctcctgcc gggagggggt gtacccggcc gccgtgatcg
    13381 cggcgacgag caggtccagc gcgtcctccg gctgtcccag ggccggtgcg aacccgccct
    13441 cgtcgccgag tcctgtggtg tggccctcga acgagagcag ggacttgagg tggtcgtaga
    13501 tctccgagcc ggctcgcacc gcctcgggca gtgagccggc gccgcgcggc gcgaccatga
    13561 actcctggaa gtccagggcg ccctgggcgt gcgcaccgcc gttgacgacg ttgaaatgcg
    13621 gtaccggcat ccggggttcg gcctcgccga cctcggcgag acgctcccag agcggcatcc
    13681 cgcgcgaccg tgcgtcagcc ttcgccgccg cgagcgagac gcccacgacc gcgttggcgc
    13741 cgagccggga cttgtccgcc gtgccgtcga gttcacggag cgcctggtcg acctcgcgga
    13801 aggaggagaa catccgtcct gcgagggcct cgctgatctc cccctcgacg tggcccgccg
    13861 cgatccgcac gccctgcccg ccgaaccgtt ccgggtcgcc gtcccgcacc tcgacggcct
    13921 cgcggctgcc cgtcgacgcc cccgcgggca cgccggcccg tacccggatg ccgtccgtgg
    13981 tcgtgaggca caccagcaag gtcggtcgtg accgggagtc gaggatttcg agcgctgtcg
    14041 tccgggcgat acgcaacatg gcggtgtcct tccgtggagt cgacctgtcc gttcaccgct
    14101 gtgtttcggc acatcggggc acctactcga tcccggcggc ggggtgcgca gtgtctgcgg
    14161 gtccgtcggg tctcgtgcgc gagcggaagg tgggcggtgc gggtgcggga tcgtgtgcct
    14221 cgtccttcgg gtggagtcgc gccggacgga gacccgctgc accggcggca gttcggggac
    14281 gggccgcccc gcaggattgt gcgcggagcc aaccagtgat cttctgaggc aagttggcgg
    14341 aagaggagga cggtggacgc acacacggag ttgggccagg accgcgcgca ctcggcgcgg
    14401 atgtacgact actacctcgg cgggaagacg aactaccgag ccgacaggga ggccgcagcc
    14461 ggggtactgc gggtctaccc gggcgccctc gtcgcggcgc gcgagaaccg cgggttcatg
    14521 caccgggcga cgcggtacgc cgccgaggag ctgggtatcc ggcagttttt cgacatcggt
    14581 accggcatcc ccaccgagcc caacctctac caggtcgccc accggttcca gccggacgcc
    14641 agggtcgtct acaccgacaa cgacccgatc gtcctcgcct acgaccgcgc cctcctgacg
    14701 gccggtcccc cggccgcgat cgcctacatc gacgccgacg tgcgcgaacc ggagacgatc
    14761 ctcgaacggg ccgccgagac cctcgacttc gacgagccgg tggcactctc cctcgtcgcg
    14821 ctgctgcact tcatcccgcg cggcgacgac ccgcacaggc tggtcgcacg cctcaccgag
    14881 cgcctcgcca ccggaagcct cctcgtcctc tcgcacgcca ccaccgactt cgacctgccc
    14941 gacagcacgc acacggtcgc cgcggcggcc cgcgcgtacg aggagaaggg gctgatgctg
    15001 gggagggtca cccgcgagga gatgggcgcc ttcttcgagg ggctggagct cgccgctccg
    15061 gggctcgtgc cgacctcgga gtggcgcccg gacctcgacc tcgccgaggg gctgcaacgc
    15121 ctgccgggga tgatcagccc ggacgaggtc ggcgtctggg cgggcgtcgg ccgcaagccg
    15181 tagagccgga ccgcggttca cctgcgcgga gttggctgcg cgtgcaggca gggcgtgtca
    15241 gtggcgccgc cgcagcggcg cccggcctta cgctgtcccg gccgcccgga gcggccgggg
    15301 gcgccggcgt acgaccggcc gtccgcgcac gggtgccgcc tgcccgcccg ggcaccaccg
    15361 cccgcccggc cagggaggcg ccccttgcgg ccccgtaccc gtccacgccc ccgcactctc
    15421 ctcggccgca cgcccctggc cgggcggtac ccggccgccg tcgcgctcgc gctgctggcg
    15481 ctctgcccgt acctcgtgct cacgacggcc accacactga tggagccgct gctcctccgc
    15541 gagctgcacg ccacgcggtt cggcctccaa ctggccaacg gactctccaa cgccgcctac
    15601 gcgttcggcg ccgtcgccgc agccgacatc gtccagcggg tgccgcgtcg gcacgtctac
    15661 ctcgtctgcg agtgggggtt cgtcgcgggt tgcgtgctgg tgctgtgcgc ccagggggcc
    15721 gccgtcttcg tcaccggcat ggtcctccag gggctcgtca cggggatgct gctggtcgcc
    15781 gcgctgccgc cgctggtcac cgggcacggg acgcggcggc tgccgacgac cgcggcggtg
    15841 atcagcctcg gactcttcgg gatggcgacg tgcggtcccc tcgtcggggg gctcgtgggc
    15901 gccttcggcg ggtggcgtct cctcttcgcc gtgctcgccg tgctcgccgt cgtcggtgtc
    15961 acgatcggtg tcctcgcctt cgagccgaac caaccccccg cacagagcgc ggcgttcgac
    16021 tggctcgcca tcccgctggc gctcggcgcc accctgctgc cgttcttcgg cgtctcctgg
    16081 ctgacgaaga gctcgttcac cgatccgctc ttcctcgtgc ccgtcgcctt cgggctgctg
    16141 ctgggcgtcg gactcgtggc ggggcagtac cacgctccgc gtccactgat gccggtccgg
    16201 ccgatcagca acacgctgcc cgtcgccggg atactcgggg ccatgaccgt gggggcggtc
    16261 ttcacggcgc tcgtcgagct cacggagggc tacctcgtgg acgtcgcagg cgcctcgcct
    16321 ttgcaggtgg ggctgttgct ggcgccgcag cttccggggg tggtcgtcgc cgccctgctc
    16381 ttccgacggg tgcttcccac ggcaggggtt cccttgctcg cgctgtcggg gctggccggt
    16441 gtggcggcgg cgggtgcggt gctgctcacc gccacgccgt ccgatgcggc ggtggtcgtt
    16501 ccgttcgccg cgctcctcct cggctacggg gcgggtgccg gggtggcgcc cgggctgttc
    16561 atggcgggcc tctcggtgcc ctcgacgcag atcggcccga ccttcgccct cgtcgaactc
    16621 ctgcgctccg aggccgcgtt cctcgtcggg cccgtcctcc tccgcatcgc cgacgccgag
    16681 ggcctcgcca gcgggttccg cctcgccgtc ggggcgtccc tcgtgctcac ggtgctcggg
    16741 ggtgcgctca tcgtcggcgt ctacctcctc ggcggcgctc ggcttcaccg gcccgacctg
    16801 tcggcctgga tcgccggggg gtccacggcc tatcactcgc cgcggctcgg ggcgaggctg
    16861 cggaaggggt gagcgcggag ccctcccgac gcgcctgctt ggtgcgcggg ggcgcgtgcg
    16921 gggctcgtcg cccgggtacg tgcttgccgt gcgcccgctg gtgcgtcagc ggggggccgt
    16981 gccggagctg cccgcataga ggacggtggc gagctcctcg tcgagggact ggcggatctt
    17041 gccgaggacg tcgcccgagg tggcctcgtc gacgacctcg acgacgcagc gcgcggcgtg
    17101 gatcgccttg gacggatcga ggccgctgcg ctgcgccacg cggtcgaaga actcgcggcg
    17161 gtccatacgc gcgccggtga ccggttcgtc ctgcgcgtag gcgacgcggc ggaggtgctc
    17221 gcctatctcg tgcgggagtt ggtcggcgag gttctccgcc tgcgtggcct ggatgcgctc
    17281 ggcgagcgtc tccagggtgg cccgcgtgac cgcctcggcc tccccgcggc tgctgaggcc
    17341 ggcgcgggcc tgcacctggc cgatgaacgc gtcgtgctgc atgggtgcct ccggtacttc
    17401 cgggggcctg cggcgctcgg acgggacgtg cgccgcaggc ccgtgtgcga cttccgtggc
    17461 ctggtcaggt gttgggcgtg ctggcgctga tgtcgcccag ggccgagtac ggttcccgct
    17521 cgacggagag gtcgcccaac gagacgacgc cgatcacctg cccgtcgtcg agaaccggca
    17581 gccgacgcaa agccttcccc cgcatcagct ccaccgctcc gccgaccggc tcctccggag
    17641 cgaccgagac gagctcgcgg ctgcacgcct cgcgtacccg tatgcccgtg acgtcgccgc
    17701 cgcgagcgag gatgcgcacg gtcaggtcgc ggtcggtcac cagtccccgc ggttcgcccg
    17761 cctcggtcac cagtaccgca ccgatgtcct cgtcccgcat ccgtgcggcg acgtcgctca
    17821 cgtacgcggt ggtgctgacc tgcaccggtg cttccgtcat gatctcccgt accgtccggg
    17881 gcatcgcata cctccgaggt ctgctcgcgg gaccgacgcc gctcgggcgg ccgccgaccg
    17941 gtcggtgtgc cgggtctccc gtccgacgcg gacgaaacac gggcttccgg gcgtgaacag
    18001 caccggggct accgctccgg cgcgaagagg ccggggaaat gtgcgccgtc ggcggtggac
    18061 gcgagcaacg ctcatggtgc ggaagtctga accaactgtt ctttgacgca cggaagttgg
    18121 gcacgaaacg ccgtctgcac ggacggagcg ccccggatgc cctggggcgc gaggttgtgg
    18181 accacctcgc actctggaca tgtatgcgaa tcgcatagga ttgccgcatg gagtctccac
    18241 tggaagcagc catcgacgag tggcacgcga gcgtgaatga gggcgctccg gagcggtcgg
    18301 cgagggcggt cggtcgtccg ctcgtcgttc ttggccccaa gggcgccggc ccgatcgacc
    18361 ccgagcagtt cgcagagtgg gtggaacgct cggggatcaa gctcatcccg cggtcctggc
    18421 atccggtcag tgagcgcctc atggtcgtgg agcaagacgc cacctggccc gagagcgagg
    18481 gtccggctcg ggtggcgacg gttttccggg tcaccggaga gagagtgacc gccgctctcc
    18541 ggctgcccga tctggagtcg gcgctcgaat tggcccgtgt ctgccgcgag atggcggcca
    18601 ccgaatgacg gccccggggc cggggcagat cctgttcgcc tttgtccggc actggtcgcg
    18661 cagaccgccg acgagtgagg gcaagctcgc cgagcaaggc cgactcgtgc tcgtcaccga
    18721 ggctgcccac tccctgactc agcgaggcat cgcggcaacg gtcaatgccc tcgcccacga
    18781 gatcggcatc gaccagagcg gagcgtcgcg actggtcaag agcgctacgg aggctgagta
    18841 cctgaccatg caagcgtcgg agacagacgg ccgccgacgc caagcgtcgg tcaccgcatc
    18901 cggccgcgcc ttgctggagc aggctcaccg ctggcaggaa gaggttttcg gccgactgac
    18961 agaagactgg agcgaacagc agcgccgcga tttccagcga gcgatgacag acctgatcga
    19021 ccgctcctac gcgctgggca cgtgaatacg gttccccccg ctctccaagt gcggcgcggg
    19081 ctgcggggag ttcggatcgc gcccggcagt gtgcgctgcc tgtcgcagag tcctctggtg
    19141 cggtcgaagt gctggacgga gtcgcggacc cgcaggtacg cgaggcccgg tccctcgggc
    19201 atggaccccc tcgcgaatct tcccgggcat cggtccacct gtgacctgtc cgcaccggca
    19261 gggcgtacgg gcaggttccc caacttgcat gtgagccagg cgagtcgacc ggaggacgac
    19321 cactctccga gcgtgctccg cgcacagcat gtgcacactg cgggacacga tgcgggggct
    19381 cggaacgagg cggagtcgca gacgggcaga gcctccgatt ccccgagagg gccgcctctc
    19441 ctttcggaca cgaccgcgcg cggtgcgcag tggaggccat ggcgacaccc ttccgcggcc
    19501 cgaggtcggc aacgcccgca ggacgcgccg cagccgcggc tgtgcccgac cgtcccgtcg
    19561 tgcggctagt ttggcgcggc agggaccgtc tgccgtaagg actgccatga gggatctgat
    19621 cgtcaccgag aacatcacgc tcgacggggt gatcgaagcg gcaggcgact ggttcgcacc
    19681 ggcgaacacc gacggcgacc gctcggacat ggcggcggcg ttgcagcggc aggccgagat
    19741 ggccgacgcc ttcctcaccg ggcgagtcac ctttgaggag atgcggagct actggcccca
    19801 ccgggccgag gacggctcgt acgtcgcgga gtacctcggc cgggtgcaga agtacgtctt
    19861 ctccggcacg ctcacccacc ccgagtggga gcacaccacg gtgctcaggg gaacgctgga
    19921 ggccgagatc cgcggactga aagcggaacc cgggcgggac atcgtcgcca ccggcagcat
    19981 ctccctcgtc cacgcactcg ccgcggccgg ggtcgtcgac gagtaccgcc tcttcgtcca
    20041 ccccgtggtg ctcggcacgg ggcggcggct cttccccgac ggggccgcac cacgccggct
    20101 gcgcctcacg gagacatcgg ccttcgcgtg cggggtcgtg ctgctccggt accgggtggg
    20161 gtagcggggc aacggaacga tgtgtgcggc ttgttgctgg ggcggtgcat cgacggtgct
    20221 cacacgaagg agcgggcggc ggcggcagta ggttgacgac tcggcgggca gcacttgcgg
    20281 agccctgtca ccggtcccgg aggacaccat gcgtccgcgc cgcctcgcca ccgtcgccgc
    20341 cctcgccgtt gccggcgccc tgctcccgct ccccgccttg gccgccgcta ccgccttcgg
    20401 ggggccggcg cccgtctgcc aggagaacgg cctcttcccc cacgcggagg acgcccgata
    20461 cttccaccac tgctccgggc acaggccgca cctgaagaaa tgcccggcca accttcgctt
    20521 cgatccgcag ctccgcgtct gcgcctacgc gaagaaggcc aacacccctc gtgtctgacg
    20581 ggcgggaccg ttgcccgcag tcaaccgtcg cgaggctccg aactcccctc caccattggt
    20641 tgtttgggcg cggtgtccag gttgagcgag aggacgtcgg ggcgtgcgta gtggcccgac
    20701 gcgtcgaagt cgaggctctg gcggatgatc tcgtcggtgt cgacctccgc gtagaggagg
    20761 cactcctcgt cgtgaacggg gccggcgagg agatccccgc gcggcgagac gacggcgctg
    20821 ccaccgcgca tcagcaggtc gtcggggtcc gtgccgaaga gcggtgcgta gtcgtccgga
    20881 tagtcgcggc ggcgcatcac ctggcaggcg gtgaggacga agcagcgccc ttccagggcg
    20941 atgtggcgga cggtgggcag ccaggtctcc cggtcgtcgg ccgtgggcgc gcagtagatc
    21001 tcgacaccct tcgcgtacat ggcggcacgc agcagcggca tgtagttctc ccagcagatg
    21061 acggcaccga gcgcgcccgc aggggagtcg acgacgggga gcgtcgagcc gtcgccgaag
    21121 ccccagatga gccgctccgc ccccgtcggc atcaacttgc ggtgataccc gacgcgctcc
    21181 ccgcgctcgt cgatcatgac gacggtgcag tacaacgtcc gccccatccg ctccacgaca
    21241 ccgatcacga cgaacacccc gtgctccctc gcggcagcag ccaccactgc gagctccggc
    21301 ccgtccaact ccaccgccgc gcggtacgac cgcaggaact cgtccctgcc ctcctccgta
    21361 cgcctgccga ccgggctgcc gaaggagagg cccttcgggt aggtgccgag gaacgcctcc
    21421 gggaagacga cgagccgcgc accggccgcc gcggcctcgg caagcgcggc ggcggctttg
    21481 cgggcggttg cgtcgggggc gaa
//
