LOCUS       NZ_KB905814            20552 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Streptomyces sulphureus DSM 40104 F603DRAFT_scaffold00002.2, whole
            genome shotgun sequence.
ACCESSION   NZ_KB905814
VERSION     NZ_KB905814.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sulphureus DSM 40104
  ORGANISM  Streptomyces sulphureus DSM 40104
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 892984)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name :: Streptomyces sulphureus DSM 40104
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 40104, ATCC 27468
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R37654
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11971
            Current Finishing Status          :: Level 1: Standard Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Sporulation                       :: Sporulating
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R37654
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000381025.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 01:54:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,193
            CDSs (total)                      :: 6,120
            Genes (coding)                    :: 6,022
            CDSs (with protein)               :: 6,022
            Genes (RNA)                       :: 73
            rRNAs                             :: 6, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 5 (5S)
            partial rRNAs                     :: 1, 3, 1 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 98
            CDSs (without protein)            :: 98
            Pseudo Genes (ambiguous residues) :: 0 of 98
            Pseudo Genes (frameshifted)       :: 37 of 98
            Pseudo Genes (incomplete)         :: 75 of 98
            Pseudo Genes (internal stop)      :: 11 of 98
            Pseudo Genes (multiple problems)  :: 20 of 98
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:55:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 122266
            Orig. end                         :: 142818
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905814.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405920
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20552
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="2"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..20552
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20552
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10552](-)"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10552)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     misc_feature    617..628
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.54"
                     /tool="antismash"
     misc_feature    complement(818..833)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            complement(1271..1852)
                     /locus_tag="F603_RS0104825"
     CDS             complement(1271..1852)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544886.1"
                     /locus_tag="F603_RS0104825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_019544886.1"
                     /transl_table=11
                     /translation="MSDTVAEPEKKVGRQERILDATLTLLSQHGISGVSMRAVAREAGV
                     ALGLVNYHYDDKTTLISAALRRIEEQDVALVEPDPSKSPEENLRSALRRIADAEFLTTE
                     YLSLRLQLWALARAHADFGEINTAAQKRYRKALTALIRAARPELSGAEAGRRATDIDIV
                     QNGLWLTALLGIDRASIRRSVRHCEEIAFQ"
     gene            complement(1955..2923)
                     /locus_tag="F603_RS0104830"
     CDS             complement(1955..2923)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907290.1"
                     /locus_tag="F603_RS0104830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PDR/VanB family oxidoreductase"
                     /protein_id="WP_019544887.1"
                     /transl_table=11
                     /translation="MPLANDSSSLKLRLVRRTPVANGVVLLAFAAADGAELARWDPGAH
                     LDLRLPSGLRRQYSLCGDPADRATYTVCVLREEAGRGGSAEVHDRLDVGAEIESSHPRN
                     HFPLVEAPDYVLLAGGIGITPLKAMAEELQRRGASWRLVYGGRDRQSMAFAEQLASSHP
                     ARVTLVPQDEAGVPDVERIVATLSPETRLYCCGPPPMLAAATEECARAGVGDRLHVERF
                     APAEGTPETSADSAFEVELRETGVTLTVPADQSLLEAIRAVRPTIDSSCQEGYCGTCET
                     RVLKGRPEHRGTLLSPEEHDEEGTMLICVGRSRSAKLVLDL"
     gene            complement(3040..4038)
                     /locus_tag="F603_RS0104835"
     CDS             complement(3040..4038)
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544888.1"
                     /locus_tag="F603_RS0104835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-hydroxyacyl-CoA dehydrogenase NAD-binding
                     domain-containing protein"
                     /protein_id="WP_019544888.1"
                     /transl_table=11
                     /translation="MSPSEQPAQHVAGSGDFARVASLGAGVIGRSWTALFLAAGKSVAV
                     YDPDPQAEARVRQAVESAWPVLTQLGLTEHGDPENVHFCADPRAAVDGAAFVQESVPER
                     IALKHDLYAAIGPALDADAVVASSASGLTLTEMQEGWRDPGHFVLGHPFNPPHLIPLVE
                     VMGNDRTAGGAVDRARAFYASVGKVTIEVRREVPGHVANRLQAALWREAIHLVNEGVAS
                     VEDVDTAVSSGPGLRWAAMGPTQLFHLGAGEGGLAAFCERYADSFNRWFDDLGRPHLDE
                     ATSQRLVDGLGPISEKHSVDELAHRRDALLTELIATARKQATGRGTDPRRH"
     gene            complement(4025..4954)
                     /locus_tag="F603_RS0104840"
     CDS             complement(4025..4954)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907292.1"
                     /locus_tag="F603_RS0104840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-keto-5-aminohexanoate cleavage protein"
                     /protein_id="WP_019544889.1"
                     /transl_table=11
                     /translation="MPEPVIITCAPTGGIHTPTMSPHLPITPEEIAQASVEAAEAGAAV
                     IHLHARDPETGKPDPRPELFQEFLPQISARSDAVVNVSTGGGLGMSREDRLRAAVAVSP
                     EMASLNVGSLNFGIFPMLEKYDRWQHAWEPEFLESTRDLVFKNTFADLEYIVKELGGEH
                     GTRFEFECYDLGHLYNLAWLVDQGWLQPPFFVQMVFGVLGGVGADLDNLVHMHTVAEKL
                     FGDDYEWSVLAAGRHQMPFATQAAMLGGNLRVGMEDSLFIGPGQLAASNADQVAKIRTI
                     VESLGRSVATPADARRRLGLKGADRVAF"
     gene            complement(4993..6147)
                     /locus_tag="F603_RS0104845"
     CDS             complement(4993..6147)
                     /EC_number="1.14.13.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013044.4"
                     /locus_tag="F603_RS0104845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aromatic ring-hydroxylating dioxygenase subunit
                     alpha"
                     /protein_id="WP_037955413.1"
                     /transl_table=11
                     /translation="MTDVTADQVTAIAAGYDEDPANSMSLRADAYTEPKWYAIDQQAIF
                     ARTWQWICHVEKLTQPGSYVAATVAGMPVVVVRDRRGGLRAFYNVCKHRAHELLSGSGT
                     TRTIVCPYHAWTYDLGGSLVGARQTDRMETFDKTEICLDQVQVEEFCGFVYVNLDPTAT
                     PLAEQAPDLAADITRRAPDIADLTHAKRLYYEVETNWKNVIDNFLECYHCHVAHKEFVS
                     LVDMETYDVKTHGIWSSHFADAGTSENTAYDVSDATVTEHAVWWLWPNTCLLRYPGRGN
                     FMVFQVWPDGPGRTLETWDFFLESTELNEAEEQSVQYIDEVLQVQDIDLVESVQRGMGT
                     PAFNQGRIIYDPERAPGLSEHGVHHFHGLVLDAYRALAGDQSPS"
     gene            6288..7649
                     /locus_tag="F603_RS0104850"
     CDS             6288..7649
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907294.1"
                     /locus_tag="F603_RS0104850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent succinate-semialdehyde
                     dehydrogenase"
                     /protein_id="WP_019544891.1"
                     /sec_met_domain="Aldedh (E-value: 2.2e-129, bitscore:
                     427.5, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRYAVTNPATDEVVQEVPTITDEALELALDASRAAQSSWAREST
                     VEQRSALVARVGALHAERRREFADIIVREMGKPVGEALGEVDFCADIYRYTAESAPSCL
                     ADQEIPLPAGEALVRSAPLGVLLGIMPWNYPAYQVARFAAPNLAIGNTILLKHAPQCPQ
                     SAAFLEQLFVDAGFPAGAYTNIYASNDQAARLIADPRTAGVSLTGSERAGRAVAELAGR
                     HLKKVVLELGGSDPFLLLGSEDLDAAVGQAVAARLDNGGQACNAAKRIIVVDDLYDEFA
                     DRFIREFTAVEPADPTEPATVLGPLSSTEAADRLEDQVESAVAHGATVHRRASRRGTFF
                     PPVVLTDLSPENPAHHEEFFGPVAVLYRVRDEEEAVAVANDTPYGLGSYVFTPDREQAV
                     RVADRLEAGMVFINEVGAEGAELPFGGVKRSGTGRELGHLAFNEFVNKKMIRSA"
     gene            complement(7886..8707)
                     /locus_tag="F603_RS0104855"
     CDS             complement(7886..8707)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (32-260). E-value:
                     1.8e-21. Score: 68.8. Matches aSDomain:
                     nrpspksdomains_F603_RS0104855_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907295.1"
                     /locus_tag="F603_RS0104855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_019544892.1"
                     /sec_met_domain="PF00561 (E-value: 1.6e-15, bitscore: 52.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.2e-17, bitscore:
                     60.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGYTDGAEVPARTARLGDLDVTWSERGRNGAPVVFLHGLAEDRH
                     TWSYQQNALEDLHTYAYDLRGHGDTPAGRTDGTLSQLGGDLVAFLDAVTGPATCVGFSL
                     GGTVVLWTAAHRPDLVPHPVVVATSTVVGRAAAAFYEQRRAIAESGDRVVIEDALREDS
                     AGALVGRADLLERVVASRTKAVGGAEGYVNGLRTMRALREEPLTPLLEGITAHVDVIGG
                     EFDALCPRKAADIMLTNLPDAAYHEVPGVGHLMNADDPAGVTTVLRTILAR"
     aSDomain        complement(7928..8611)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F603_RS0104855_Abhydrolase_1.1"
                     /evalue="1.80E-21"
                     /label="F603_RS0104855_Abhydrolase_1.1"
                     /locus_tag="F603_RS0104855"
                     /protein_end="260"
                     /protein_start="32"
                     /score="68.8"
                     /tool="antismash"
                     /translation="PVVFLHGLAEDRHTWSYQQNALEDLHTYAYDLRGHGDTPAGRTDG
                     TLSQLGGDLVAFLDAVTGPATCVGFSLGGTVVLWTAAHRPDLVPHPVVVATSTVVGRAA
                     AAFYEQRRAIAESGDRVVIEDALREDSAGALVGRADLLERVVASRTKAVGGAEGYVNGL
                     RTMRALREEPLTPLLEGITAHVDVIGGEFDALCPRKAADIMLTNLPDAAYHEVPGVGHL
                     MNADDP"
     misc_feature    8925..8939
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.19"
                     /tool="antismash"
     gene            complement(8943..10004)
                     /locus_tag="F603_RS0104860"
     CDS             complement(8943..10004)
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907296.1"
                     /locus_tag="F603_RS0104860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase"
                     /protein_id="WP_019544893.1"
                     /transl_table=11
                     /translation="MTTPEEQARAEADAAWLRTTVMSGFLLSQIAGTLTRVGAVDALGE
                     RSGTAEEVARDTGTHAPSLRRLLRAGCVLGLVTTGEGGRFALTPFGAEFRRGTPARLAA
                     DLYGTPALWDAFGALEDAVRTGTPAFEKRHGTGFYESFAADEALGERFTAAMASGTAAQ
                     APLVADSCDWGRFAHVVDVGGGDGTLLAAILAAQPGLHGTLYDRPEALRPAPDTLKSAG
                     VAGCCTLLEGDFLASVPAGGDAYLLRNILHGLDDASCVRVLDLCRGAAGPDGTVLVATL
                     LLPREGETVEAAGVLHTMLSDIETLTLTSGRERTLAEYEELLGRAGLRCKKVTELAGLP
                     CHAVLEAVPDLGA"
     gene            complement(10001..10552)
                     /locus_tag="F603_RS0104865"
     CDS             complement(10001..10552)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544894.1"
                     /locus_tag="F603_RS0104865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019544894.1"
                     /sec_met_domain="cypI (E-value: 4.9e-35, bitscore: 116.3,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRHNGASLAAEAALYGLLGTWFALTVGQQFKKRPRFLERVDPGN
                     VTLPVSTFFAPRPGTTDTHLLVRDELLDGSTTEWAEYPVSQDRSLRQMVWHPNRRREKA
                     LCDVQNDLAFLVRQDKGPEHIHMTVPYLALLNFVSHRCPHAPDSRRVQFLLVASGGHDE
                     TEEPDVLLASDFHTLDTEGR"
     gene            complement(10549..12405)
                     /locus_tag="F603_RS0104870"
     CDS             complement(10549..12405)
                     /NRPS_PKS="Domain: Abhydrolase_1 (355-490). E-value:
                     7.7e-15. Score: 47.1. Matches aSDomain:
                     nrpspksdomains_F603_RS0104870_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907298.1"
                     /locus_tag="F603_RS0104870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_019544895.1"
                     /sec_met_domain="PF00561 (E-value: 9e-12, bitscore: 40.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNTRRDDIDAVFRKVERCTSVGATISALEQLASSSLHADDDLLS
                     WPVLKLHAPQWWRSAGEGRLDALFGYPNVLSLPGTRMLAGLGLLLPGTTRAQRGALAAT
                     MCGTAYGMQTQMRYGLDGSDHMAFLNFASSALEKLFPDNARAREAVVVFLAAQACLSYF
                     TSGAAKLASPVWRDGTAIPGIFRTATYGDRFFYELVRDRPWLAKTVAWSTIAGELAFPL
                     ALVAPKPVARGLLATGTAFHLGNAKFMGLNRFVWSFCATYPAVAHVSRALGPRKEAPAK
                     KPLNGATWRGGSVRTAPRAASLLVGAGAAAVAGAAVYRRVRSGRARAVAVPGELVTVGG
                     RDVHVVARTGGSGPTVVFENGMACPATGWSWVWEGMEPGTRYVAYDRPGTGWSAPAKGP
                     QDAERASAGLRELLARLGAEPPYVLVGQSVGGLLIRSFARRHPELVGGLVFVDASHPDQ
                     LARSAGQRRTLPWLRQRMTSTWLRAELGMLPEPQRLGPFSSLPAPLAAQTVERMKAPAS
                     WRAARREMSQWPRSWSADAAKLTDAGGRPVAVLTASGTVERDPVHADLQAELAALSHES
                     RHDLVPGATHESLVMDPQHAPHVADAIAWTRKRAAVGEGSLR"
     aSDomain        complement(10936..11340)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_F603_RS0104870_Abhydrolase_1.1"
                     /evalue="7.70E-15"
                     /label="F603_RS0104870_Abhydrolase_1.1"
                     /locus_tag="F603_RS0104870"
                     /protein_end="490"
                     /protein_start="355"
                     /score="47.1"
                     /tool="antismash"
                     /translation="VVFENGMACPATGWSWVWEGMEPGTRYVAYDRPGTGWSAPAKGPQ
                     DAERASAGLRELLARLGAEPPYVLVGQSVGGLLIRSFARRHPELVGGLVFVDASHPDQL
                     ARSAGQRRTLPWLRQRMTSTWLRAELGMLPE"
     CDS_motif       complement(11107..11145)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_F603_RS0104870_0001"
                     /evalue="2.60E-03"
                     /label="NRPS-te1"
                     /locus_tag="F603_RS0104870"
                     /protein_end="433"
                     /protein_start="420"
                     /score="10.4"
                     /tool="antismash"
                     /translation="PYVLVGQSVGGLL"
     gene            complement(12481..12762)
                     /locus_tag="F603_RS0104875"
     CDS             complement(12481..12762)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907299.1"
                     /locus_tag="F603_RS0104875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019544896.1"
                     /transl_table=11
                     /translation="MAVSRTTRIADWAQHHAEFGERHVPRSDEPLPVLLTPAAVFAGVT
                     AAQTAAQVGLTAAAGALGYDDHGSTVPSTALDTGRSVGDTLAHHPQGF"
     misc_feature    12780..12800
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.17"
                     /tool="antismash"
     misc_feature    12920..12934
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.41"
                     /tool="antismash"
     gene            complement(13230..13400)
                     /locus_tag="F603_RS35320"
     CDS             complement(13230..13400)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544897.1"
                     /locus_tag="F603_RS35320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019544897.1"
                     /transl_table=11
                     /translation="MSTGRDREPRLDAAEANDAIRRFVAGRTVWTPADLVELDRLRAEW
                     REARRGCTAAA"
     gene            13726..13917
                     /locus_tag="F603_RS0104885"
     CDS             13726..13917
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907302.1"
                     /locus_tag="F603_RS0104885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_019544898.1"
                     /transl_table=11
                     /translation="MSNQERRERYARALYATLGFSAERHPWEGLAAARREVWYVRADAA
                     LALADEEIAEALESERQR"
     gene            14018..15739
                     /locus_tag="F603_RS0104890"
     CDS             14018..15739
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544899.1"
                     /locus_tag="F603_RS0104890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_019544899.1"
                     /transl_table=11
                     /translation="MPRLPRSPFTAPGEQGRGVWRALAEVAGGVLLISLGQVVVSSADE
                     QLPLSQYALSVPVLGLFAVRRRYPVVSLLGIAALAGAQPAAGLPAAVTAYTATRQLTAP
                     RHRTALLLASTLLVLLTSTALAAFAGSEGQTSGPAVGAVLAATALLVPGLVGTSVGQQD
                     RLMPALRERAAAAEEARRLAESESRMQERSRIAAEMHDLVGHRLSLISLHAGGLEMALR
                     DESAEMRDEAALVRRATGDAMQELREVLGVLGPLGRDTGTGALTDTTGTRSDIEALAEE
                     SRSGGIPVELTWEGADLDDRPAQVRRAVHRVVRESLTNVHRHAAGAHVTINVTHTGDRV
                     EVLVRNGRAPLQGAAQQGSGRGLVGLRERVSLLGGELESGPTPAGGFAVTAHIPAQPDP
                     HAGTAGSGDARPEPAEPGAERAPSGVQRRVVGALTGLLGLTGVSVMILFGLFLVSEANR
                     TPQAAEEVEPRIGMHREELGPSLWDDTGVRAAATGHEPARPESATECIYPMVPSEDFLP
                     LSEGAGMGPMEYAPFDAQEGPGQLRITRYCFHGDELTAIDRFNVPVVSQTPSWESP"
     gene            15736..16422
                     /locus_tag="F603_RS0104895"
     CDS             15736..16422
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544900.1"
                     /locus_tag="F603_RS0104895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_019544900.1"
                     /transl_table=11
                     /translation="MTVHPDRPIRVLLADDETMIRHGVRLILRHAEGIEVVGEASDGEE
                     AVRLATEAKPDVALIDIRMPVLDGLATIDPLLALQPRPQVVMLTTFGDEENVTRALRSG
                     ATGFLLKDEGPQELISAVRSAAAGDAVLSPGVTGTVIERMLSGSSDAASPPRGTAPEQQ
                     LSELTGRERDVLTLLGGGLANVDIGRRLGIGVGTVKTHVSAILEKTGTDSRVQAAVLAY
                     RTGLLS"
     gene            16589..17374
                     /locus_tag="F603_RS0104900"
     CDS             16589..17374
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907305.1"
                     /locus_tag="F603_RS0104900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_019544901.1"
                     /transl_table=11
                     /translation="MSMQAAVSASVHSPQSSAAARATELSKVYGEGETRVVALDSVSLE
                     FERGRFTAIMGPSGSGKSTLMHCMAGLDSVSGGSARIGDTELSRLNDRQLTRLRRDSVG
                     FVFQAFNLLPTLSASENITLPMSIAGRRPDPQWLDTVVQTVGLSGRLDHRPAQLSGGQQ
                     QRVAVARALASRPEIIFADEPTGNLDSRSGGEILGFLRNSVRELGQTVVMVTHDPTAAA
                     YADRVVFLADGRLVDELFTPTAESVLDRMRRAGTAGRTD"
     gene            17425..19983
                     /locus_tag="F603_RS0104905"
     CDS             17425..19983
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016907306.1"
                     /locus_tag="F603_RS0104905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_019544902.1"
                     /transl_table=11
                     /translation="MLRTALRNLIAHKTRLIMTALAVVLGVAFVSGTLVFGDTVTRALR
                     GASADNLKDVAVSVQAESEWESESDAVEDRSTALTGDLAEKVKDVPGVTSVRPTVNGTA
                     TLATKDGRPLNADMSWQNLATNYAPDDHDRDSRYPLSTGRAPTGEDELLLERRTAEKAG
                     YELGDTVRFAVNGPALTGRLVGTVETDDPRVTAGGSLVLFDTDTAQRLLLQPDRFDELA
                     VGSAPGTDNRQLAQEVSEVLPEESITATSGAELAKEQADDIVRSTGEMTKVLIAFAGIA
                     LFVGIFLIANTFTMLVAQRSRETALLRAVGASRRQVVRAVLIEAGLLGLVASAVGFALG
                     IGIATAMRPLLNMAGAGLPDGSLVISAGTLVWSLVVGVGVTVFAAWLPSRKAAKVAPVE
                     ALSTVDQAPPKRSMVFRNSLGGVLTGAGVLVMLLVSTQEGGDDSNLLAAAFGSVLTLIG
                     MIALAPLLSRPLVRLAGALTSRLSGVSGMLARENALRNPRRTAATASALMIGLTLITGM
                     SVVGKSTQAALEDDAVRGMTAEYKVSDADFNGIEPALGAKVDDVPGVTASAPLTSSTLM
                     AEDEFATVTGADPKRLERVTDLKFTSGSLAGVGPGEVALSEEYAEKTGLSQGDTFRAEI
                     GAEDSQKLTVAGVYESTRVVEDVLGTYDDVLPYSEGGKLDSVLVGTAPGTEGLDQDIRE
                     ALGNSPLLQVQDKEQLTKEEAGPIDLLLNMMYGLLGMTVVIGVLGVVNTLAMSVFERTR
                     EIGLLRAIGLDDRGVKQMVRLESVVISLFGAALGVGTGIFLAWSLGSLTGSSLTTYETV
                     LPWARLGLFLLLALAVGVLAAVWPARRAVRLNMLRSLNAE"
ORIGIN
        1 gaagagttcg ggacagcact ggaagccgcc gtgctcgggg ccggtgtcgt tgagtgccac
       61 gatgccctgc acccgctgcg ggggcactgc cagcgtggtg tcgacgtccc agtgcagttc
      121 gatgtcgaaa ccgcgctcac gggactcgat cagcgaacgg tccctggttc ctgaattcgg
      181 tgggttcagg ttcatgcggt ccaaagtcac ccacaactcc tcgcagtccc atacgtcgac
      241 gaacgcgtcg tacacacgct gggtctgacg gctgtcccac agaagctggt ggtgataggc
      301 ctcgacgaag ccgtagatgt gcagctccct gtcgaggtcg gagcggtact cctgcttttc
      361 gtaccacgtc tcgggacggt cagggtcaag tccctggaaa tcccacgcga aatccagcag
      421 gcgcccggcg gcgtccggat cgatcgcccg cttgaccacg acgtagccgt agttctgcca
      481 gaacgtgaag tcctcttctg acagcactct gaggggccgt gacttcttca ggtcgcgcag
      541 ccgcgtgggg gccaggtacg tctcgccgtc ggagctgaaa tacgggaggt cggaagcggc
      601 gcgatgcaga tagggggaaa ccgttgacat gagtactagt actccaaagc tcggttcggg
      661 gtgacggctg cacgcgggcg cgaacgtcca gggctcagcc ggagcgcagc cacggcgccc
      721 tctcggcggt cgcaacagac ttcgagtagc gcacgtcggc aggagacccg gttccgcttc
      781 tttccaggtc ctcgcgtcgt gaccgtagct cagtaaagat ggactagacc aatggctcgt
      841 gtcaacccgc tcgccgctcc tggtcggcag caacgcaccc tcgtttgcgg ggagttgaga
      901 actggtgcga ctgctcggcg ccagcctctt cgtggcgccg ccgacccgcc ggcgcgggct
      961 ccgctctcgg cacggccagc ctgcttcggg cagcgcggca cccagccggc ccgctgaccg
     1021 gggttcgcgg cgtgaaaagc cagacggcgc cgctgtgccg gggcgaccgg agcagcccac
     1081 gggccgagtc ggccgaccac cgacggccgg tcgttcgtgc ccgtgcgtct cacccgcgcg
     1141 cggtgcgggc gagacgggct cgcgacccgg tgtgccgcga cgccggagga agtccccggc
     1201 cggtacgtcg tcccgtggtg ggagcagggc gactccgtcg ccgcaccgct cccggagcgc
     1261 ggcctcgcgc ttactggaag gcgatctcct cgcagtgccg gacgctccgt cggatcgaag
     1321 cgcggtcgat gccgaggagg gcggtgagcc agaggccgtt ctggacgatg tcgatgtcgg
     1381 tggcgcgtct gcccgcctcg gcgccggaca gctcggggcg ggccgcacgg atgagggcgg
     1441 tgagcgcctt ccggtagcgc ttctgggcgg ccgtgttgat ctcgccgaag tccgcgtgcg
     1501 cccgcgcgag cgcccacagt tggaggcgga gggagaggta ctccgtcgtc aggaactcgg
     1561 cgtcggcgat gcggcgcagg gcggagcgga ggttctcctc ggggctcttc gacgggtccg
     1621 gctcgaccaa ggccacatcc tgctcctcga tgcggcgcag ggccgcgctg atgagggtgg
     1681 tcttgtcgtc gtagtggtaa ttgacgagcc cgagagcgac tccggcctca cgggcgacgg
     1741 cgcgcatgct gacgccagaa atgccgtgct gggacaggag ggtgagggtg gcgtcgagga
     1801 tgcgctcctg tctgccgacc ttcttctcgg gttccgccac cgtgtcgctc acccgccgat
     1861 ggtatcgggc ggctgttcct cgcggggagg gccggaccgt cgcggggacg cggcgtgcac
     1921 tccgccgctg atccccgcgc tcagcggggc gtgctcacag gtcgaggacc aacttcgcac
     1981 tgcgggaccg tccgacgcag atcagcatcg tcccttcttc gtcgtgctcc tcgggggaca
     2041 ggagagtccc gcggtgttcc ggccgtccct ttaggacgcg ggtctcgcac gtgccgcagt
     2101 agccctcctg gcaggaggag tcgatggtcg gccgtacggc ccgtatcgcc tccaggaggc
     2161 tctggtccgc ggggacggtc aacgtgacgc ccgtctcccg cagttccacc tcgaaggcgg
     2221 agtcggcgct cgtctccggt gtgccctcgg ccggggcgaa ccgctccacg tggagccggt
     2281 cgccgacgcc ggcgcgggcg cactcctcgg tggccgcggc gagcatcggc ggaggaccgc
     2341 agcagtacag acgggtctcg ggggacagcg tcgcgacgat ccgttccacg tccgggaccc
     2401 ctgcctcgtc ctggggcacg agggtcaccc gggcggggtg cgaggaggcg agctgctcgg
     2461 cgaaggccat ggactgccgg tccctgcccc cgtagacgag tcgccaagag gctccgcggc
     2521 gttgcagttc ctcggccatg gccttgagcg gagtgatgcc gatgccgccg gcgagcagca
     2581 cgtagtcggg cgcctcgacc aaggggaagt ggttgcgggg gtgggagctt tcgatctcgg
     2641 cgccgacgtc cagccggtcg tgcacctctg cggagccgcc gcggcccgcc tcttcgcgga
     2701 ggacgcagac ggtgtaggtg gcgcggtcgg ccgggtcgcc gcagagcgag tactgccggc
     2761 ggagtccgga aggcaggcgc aggtcgaggt gggcgcccgg gtcccagcgg gccagttcgg
     2821 cgccgtcggc cgctgcgaag gccagcagca cgacgccgtt cgcgaccggt gtcctccgca
     2881 ccagccgcag cttcagcgaa ctgctgtcgt tcgcaagggg catgacggtg tctctccttc
     2941 ttgacggagc ggatggcacg gtcgccgcgg ccgattcgga tcggccgcgg cgaccgcgct
     3001 cccgctgtgc tcgtggccgg tcgtgcgcgg ccgcggggct cagtgacgac gagggtctgt
     3061 gccccgtccg gtggcctgct tccgggctgt ggcgatcagc tccgtgagca aggcgtcccg
     3121 gcggtgggcg agttcgtcga ccgagtgctt ctcgctgatc ggcccgaggc catcgacgag
     3181 ccgctgcgac gtcgcctcgt cgaggtgcgg gcgccccagg tcgtcgaacc agcggttgaa
     3241 gctgtcggcg tagcgctcgc agaaggcggc gagccctccc tcgccggcgc ccaggtggaa
     3301 gagctgcgtc gggcccatcg ccgcccagcg cagacccggt cccgaggaga ccgccgtgtc
     3361 gacgtcctcg acgctcgcca cgccttcgtt gacgaggtgg atggcctcgc gccacagcgc
     3421 cgcttgcagc cggttggcga cgtggcccgg gacctcgcgc ctgacctcga tcgtcacctt
     3481 gccgaccgag gcgtagaagg cacgggcgcg gtccaccgct cccccggcgg tcctgtcgtt
     3541 gcccatcacc tcgaccaggg ggatgaggtg cggcgggttg aacgggtgcc cgagcacgaa
     3601 gtgccccggg tcccgccagc cttcctgcat ctccgtcagc gtcaggcccg aggccgacga
     3661 ggccaccacg gcgtcggcgt cgagggcggg cccgatcgcc gcgtagaggt cgtgcttgag
     3721 ggcgatgcgc tcggggacgc tctcctggac gaaggccgct ccgtcgacgg cagcacgggg
     3781 gtcggcgcag aagtgcacgt tctcggggtc gccgtgctcg gtgagcccga gctgcgtcag
     3841 aacgggccag gcggactcga ccgcctgccg caccctcgcc tcggcctgcg ggtcggggtc
     3901 gtaaacggcc acggatttcc cggcggcgag gaagagcgcg gtccagctcc ggccgatcac
     3961 gccggcgccg aggctcgcca cgcgtgcgaa gtcgccgctg cccgcgacgt gttgggcagg
     4021 ctgctcagaa ggcgacacgg tcagctccct tcaggccgag tcggcgacgg gcgtcggccg
     4081 gggtggcgac cgagcgtccg agggattcga cgatcgtgcg gatcttcgcg acctggtcgg
     4141 cgttggaggc ggcgagttgg ccagggccga tgaagaggct gtcctccata ccgaccctga
     4201 ggttgccgcc gagcatggcc gcctgcgtcg cgaacggcat ctggtgccgg ccggcagcga
     4261 gtacggacca ctcgtagtcg tccccgaaga gcttctcggc gaccgtgtgc atgtggacga
     4321 ggttgtccag atcggcgccg acgccgccga gtacaccgaa gaccatctgc acgaagaagg
     4381 gcggttggag ccagccctgg tcgacgagcc aggcgaggtt gtagaggtgg ccgaggtcgt
     4441 agcactcgaa ctcgaacctg gtgccgtgct ccccgcccag ctccttcacg atgtactcga
     4501 ggtcggcgaa ggtgttcttg aagaccaagt cccgcgtgga ttcgaggaat tcgggctccc
     4561 aggcgtgctg ccaccggtcg tacttctcca gcatggggaa gatgccgaag ttcagcgaac
     4621 cgacgttgag cgacgccatc tccggcgaga ccgcgacggc ggcgcggagc cggtcctcgc
     4681 gcgacatgcc cagaccgcca ccggtcgaga cgttgacgac cgcgtcggac ctggcggaga
     4741 tctgcggcag gaactcctgg aagagctcgg gtcgggggtc gggcttcccc gtctcggggt
     4801 cgcgggcgtg caggtggatg acggccgcgc ctgcctcggc ggcctcgacg gacgcctgcg
     4861 cgatctcctc cggggtgatc ggcaggtgcg gcgacatcgt cggggtgtgg atgcctccgg
     4921 tgggggcgca ggtgatgatg actggctcgg gcatgcggac gcacctccgt acgggtcgga
     4981 cggatctcct ggtcaggacg ggctctggtc gcctgccagg gcgcggtacg cgtccaggac
     5041 gaggccgtgg aagtggtgca ccccgtgctc ggagagcccc ggcgccctct cggggtcgta
     5101 gatgatccgg ccctggttga aggcgggcgt acccatcccc cgctgcacgc tctcgaccag
     5161 gtcgatgtcc tgtacttgga gcacctcgtc gatgtactgc accgactgct cttccgcctc
     5221 gttgagttcg gtgctctcca ggaagaagtc ccaggtctcc agggtgcgtc ccgggccgtc
     5281 cggccagacc tggaagacca tgaagttgcc ccgccccggg tagcggagga ggcaggtgtt
     5341 gggccacagc caccacaccg cgtgctcggt gaccgtcgcg tcggagacgt cgtacgcggt
     5401 gttctccgag gtgcccgcgt ccgcgaagtg gctcgaccag atgccgtgcg tcttcacgtc
     5461 gtaggtctcc atgtcgacga gggagacgaa ctccttgtgc gcgacgtggc agtggtagca
     5521 ctcgaggaag ttgtcgatga cgttcttcca gttggtctcg acctcgtagt acagccgttt
     5581 cgcgtgcgtg aggtcggcga tgtcgggggc ccgccgggtg atgtcggcgg cgaggtcggg
     5641 ggcctgctcc gccagcggcg tggcggtcgg gtcgaggttg acgtagacga agccgcagaa
     5701 ctcctcgacc tggacctggt cgaggcagat ctccgtcttg tcgaacgtct ccatccggtc
     5761 cgtctgccgg gcgcccacca gggagccgcc caggtcgtac gtccaggcgt ggtacgggca
     5821 gacgatggtg cgcgtcgtcc ccgagcccga cagcagctcg tgtgcccggt gcttgcagac
     5881 gttgtagaag gcccgcagcc ctccccgccg gtcgcggacg acgaccacgg gcatgccggc
     5941 gaccgtcgcg gcgacgtagc tgccgggctg ggtgagcttc tcgacgtggc agatccactg
     6001 ccaggtacgg gcgaagatgg cctgttgatc gatcgcgtac cacttcggtt cggtgtaggc
     6061 gtcggcacgc agggacatgg agttggcggg atcttcgtcg tagccagcgg ctatcgccgt
     6121 gacctggtct gcggtgacat cagtcatgac agcgaccata gaccggactg gacgatcgtt
     6181 caatatgtcg gtgaacgatc gtccagctca ccccagtagg ctggacaact gttcaatcta
     6241 tgccagcatg attcttccac cgcccgaatg cgcaccagag gaggagcatg agccggtacg
     6301 ccgtgaccaa ccccgcgacc gacgaggtgg tccaggaggt tccgacgatc accgacgagg
     6361 cgttggagct cgccctcgac gcctcacgcg cggcgcagtc ctcctgggcg cgcgagagca
     6421 cagtggagca gcggtcggcc ctcgtcgcgc gcgtgggtgc actgcacgcg gagcgccggc
     6481 gggagttcgc cgacatcatc gtgcgcgaga tgggcaaacc cgtcggagag gcgctcggcg
     6541 aggtggactt ctgcgccgac atctaccgct acaccgccga gtcggcaccg tcctgcctgg
     6601 ccgaccagga gatcccgctc cccgcgggcg aagccctggt gcgcagcgct ccgttgggcg
     6661 tcctgctggg gatcatgccg tggaactacc ccgcctacca ggtagcccgg ttcgcggccc
     6721 ccaacctcgc catcggcaac acgatcctgc tcaagcacgc tccgcagtgc ccgcagtccg
     6781 cggccttcct ggaacagctc ttcgtcgacg ccggcttccc ggccggcgcc tacaccaaca
     6841 tctacgcctc gaacgaccag gcggcgcgcc tgatcgccga cccgcgcaca gccggggttt
     6901 ccctcaccgg gtccgagcgc gccgggcggg cggtggccga actcgcgggc cggcacctga
     6961 agaaggtcgt gctggagctc ggtggctcgg acccgttcct gctgctcggc tccgaggatc
     7021 tggacgcggc ggtcggacag gccgtcgccg cgcggctgga caacggcggg caggcgtgca
     7081 acgccgccaa gcggatcatc gtcgtcgacg acctgtacga cgagttcgcc gaccggttca
     7141 tccgggagtt cacggccgtc gaacctgccg accccaccga gcccgccacg gtgttggggc
     7201 cgctctcctc gaccgaggcg gcggaccggc tggaggacca ggtcgagagc gccgtcgcgc
     7261 acggagccac cgtccaccgg agggcgtcgc ggcggggcac gttcttcccg cctgtggtgc
     7321 tcaccgacct gtctcccgag aacccggccc accacgagga gttcttcggc ccggtagccg
     7381 tcctgtaccg ggtgcgggac gaggaggagg cggtcgccgt cgccaacgac actccgtacg
     7441 ggctcggttc gtacgtcttc accccggatc gggagcaggc cgtgcgggtc gccgaccgtc
     7501 tggaggccgg gatggtcttc atcaacgagg tcggtgcgga aggggctgag ctgccgttcg
     7561 gcggtgtgaa gcgctcgggc accgggcgcg agctcggtca cctggcgttc aacgagttcg
     7621 tcaacaagaa gatgatccgc tccgcgtgac gtcaggcgcc ggtcgattcc gcttcgggcg
     7681 gatcacgccg gtacctcaac ggaggtcacc gatgagcgag ttgtccgacc cggcgcggtc
     7741 gccggccgca actccccggt ggccgggagg agaagtcccg gccaccggct accgaccccg
     7801 cggaggcttg cacgcgaacg gagtgcgaaa ccacgcacgc gacgtgcgcg ggacgcgaac
     7861 cgacggaggt gagccgcggc ttggatcagc gcgcgaggat cgtgcggagc acggtcgtca
     7921 ccccggcggg gtcgtccgcg ttcatcaggt gtccgacccc cgggacctcg tggtaggcgg
     7981 cgtcgggcag gttcgtcagc atgatgtcgg cggccttccg ggggcagagc gcgtcgaact
     8041 cgccgccgat gacgtccaca tgggcggtga tcccctccag caaaggtgtg agcggctcct
     8101 cccgcagcgc ccgcatggtc cgcagaccgt tgacgtagcc ctcggcaccg ccgacggcct
     8161 tcgtcctgct tgcgacgacc ctctccagca gatcggcacg cccgacgagc gcacccgccg
     8221 agtcctcgcg gagcgcgtcc tcgatcacca cgcggtcgcc cgactccgcg atggcccgcc
     8281 gctgctcgta gaacgccgcg gcagcccgac cgaccacggt cgaggtggcg acgacgaccg
     8341 ggtgcggcac gaggtccggt ctgtgggcgg ccgtccagag gacgacggtc cctcccagcg
     8401 agaagccgac gcaggttgcg ggacccgtca ccgcgtcgag gaaagcgacc aggtcgccgc
     8461 cgagttggga gagcgtcccg tcggtcctgc ctgccggggt gtctccgtga cctcgcaggt
     8521 cgtaggcgta ggtgtgcagg tcttccaagg cgttctgctg gtacgaccag gtgtggcggt
     8581 cctcggccag accgtggagg aagacgacgg gtgccccgtt gcgtccgcgc tcggaccacg
     8641 tgacgtcgag gtcgccgagg cgtgcggtac gggcggggac ctcggctccg tcggtgtagc
     8701 cggccatggg gggctcctgg ctgtcgctgg ctcgtgagga gagcttcgtc cctctgggcg
     8761 tggccggtca aaggcggtgt cgctccttgc ttccgggagg cgctcggtcg cacgcgccct
     8821 gaggacggcg agaccgcacg gtgcgagctg ccgacagccg cgccgcgcaa cgacccgtcg
     8881 gtgcaaggtc gttgaggggg cacgccccta cccgacagac cggccgacga gccgttccgc
     8941 cctcacgccc cgaggtccgg tacggcctcc agcaccgcgt ggcagggcag gcccgccagc
     9001 tcggtgacct tcttgcacct caaccccgct ctgcccagca gctcctcgta ctccgccagg
     9061 gtccgctccc tgccggacgt cagcgtgagc gtctcgatgt cgctcagcat cgtgtgcagc
     9121 acgcccgccg cctcgaccgt ctctccctcg cgcggcagca acagggtggc caccagcacg
     9181 gtgccgtcgg gcccggcggc accgcggcag aggtcgagga cgcggacgca ggaggcgtcg
     9241 tcgagcccat gcaggatgtt gcgcagcagg tacgcgtccc cgccggccgg aaccgaggcg
     9301 aggaagtcgc cctcgagcag ggtgcaacac ccggcgacgc ccgcggactt gagcgtgtcc
     9361 ggcgccgggc gcagcgcctc gggacggtcg tacagcgtgc cgtgcagccc gggctgggcg
     9421 gcgaggatcg ctgccagcag cgtgccgtcg cccccgccga cgtcgacgac gtgcgcgaac
     9481 ctgccccagt cgcaactgtc ggcgaccagg ggggcctggg cggcggtgcc cgatgccatc
     9541 gcggcggtga accgctcccc cagcgcctcg tcggccgcga aggactcgta gaagccggtg
     9601 ccgtgccgct tctcgaaggc cggtgtgccc gtgcggacgg cgtcctccag tgcaccgaag
     9661 gcgtcccaga gggcgggggt cccgtagagg tcggcggcga gccgggccgg ggtgcccctg
     9721 cggaactcgg cgccgaacgg ggtcagcgcg aaccgtccgc cttcgccggt ggtgacgagt
     9781 ccgagtacgc agccggcgcg caacagccgg cgcagcgacg gcgcatgggt gccggtgtcg
     9841 cgcgccacct cctcggcggt gcctgaccgc tcgccgagcg cgtcgacggc tccgacgcgc
     9901 gtcagggtcc cggcgatctg gctcagcagg aagcccgaca tcacggtcgt cctcagccac
     9961 gccgcgtcgg cctccgcacg cgcctgctct tccggggtgg tcatcggccc tccgtgtcga
    10021 gcgtgtggaa gtcggacgcc aagaggacgt cgggctcctc cgtctcgtcg tgaccgcccg
    10081 aggcgacgag gaggaactgc acgcgccggg agtcgggtgc gtgcgggcag cggtggctga
    10141 cgaagttgag cagtgcgagg tacgggacgg tcatgtggat gtgctcgggg cccttgtcct
    10201 ggcgcaccag gaaggcgagg tcgttctgca cgtcgcagag cgccttctcc ctgcgcctgt
    10261 tggggtgcca gaccatctgg cgcagcgacc ggtcctggga gacggggtac tcggcccact
    10321 ccgtggtgct gccgtccagc agctcgtcgc ggacgaggag gtgggtgtcc gtggtgccgg
    10381 gccgcggggc gaagaacgtc gagacgggca gcgtgacgtt gccggggtcg acgcgctcca
    10441 ggaaccgggg acgcttcttg aactgctggc cgacggtgag cgcgaaccag gtgccgagca
    10501 gcccgtacag ggcggcctcc gctgcgagcg aggctccgtt gtgccgcctc atcgaagact
    10561 cccttccccg accgccgcgc gttttctggt ccaggcgatg gcgtcggcga cgtgcggtgc
    10621 gtgctgcggg tccatgacga ggctctcgtg cgtcgcgccc ggcaccaggt cgtgccgcga
    10681 ctcgtgggag agcgccgcga gttcggcctg gaggtcggcg tggaccgggt cgcgctccac
    10741 ggtgccgctc gccgtcaaca ccgcgacagg gcgtcccccg gcgtcggtca gcttcgccgc
    10801 gtccgccgac caggagcgcg gccactggct catctcgcgc cgcgcggccc gccaactcgc
    10861 cggtgccttc atccgctcca cggtctgcgc ggcgagcggc gcgggcaggg aggagaacgg
    10921 gccgagccgc tgcggctcgg gcagcatgcc gagttcggcg cggagccagg tggacgtcat
    10981 ccgctggcgg agccagggga gcgtacgccg ctggcctgcg gagcgggcga gttggtcggg
    11041 gtggctcgcg tcgacgaaga cgagcccgcc gacgagttcg ggatgccggc gcgcgaagct
    11101 ccggatgagc aacccgccga cggactgccc gacgaggacg tacgggggct cggcgccgag
    11161 ccgcgccagc agctcccgca gaccggcgct ggcccgctcg gcgtcctgcg gccccttcgc
    11221 gggcgcgctc cagccggtgc cgggccggtc gtaagcgacg tagcgggtgc cgggctccat
    11281 cccctcccac acccagctcc acccggtggc ggggcaggcc atgccgttct cgaagacgac
    11341 ggtgggaccc gagcctccgg tccgtgccac cacgtggacg tcccggcctc ccacggtgac
    11401 gagttcgccg ggcacggcga ccgcgcgtgc gcgcccgctc cgcacgcgcc ggtacaccgc
    11461 cgcacccgcc acggcagccg cgccggcccc gaccagcagg ctcgccgccc gcggcgccgt
    11521 acgcaccgag ccgccgcgcc aagtcgcccc gttgagcggc ttcttggcgg gtgcctcctt
    11581 ccgcgggccc agcgcccggg agacgtgggc gacggcgggg taggtggcgc agaacgacca
    11641 gacgaagcgg ttcagcccca tgaatttcgc gttccccaga tggaaggccg tccccgtcgc
    11701 gaggaggccg cgggcaaccg gcttgggcgc caccagggcg agagggaagg cgagttcgcc
    11761 ggcgatcgtc gaccaggcga cggtcttggc gagccaggga cggtcgcgta cgagctcgta
    11821 gaagaaccgg tcgccgtagg tggcggtgcg gaagatcccc ggtatcgcgg tgccgtcgcg
    11881 ccagacgggc gaggcgagtt tcgcggcgcc cgaggtgaag tacgacaggc acgcctgcgc
    11941 ggcgaggaag acgaccaccg cttcgcgggc gcgggcgttg tcggggaaga gcttctccag
    12001 cgccgagctg gcgaagttga ggaaggccat gtggtcggac ccgtcgaggc cgtaccgcat
    12061 ctgggtctgc atgccgtacg cggtgccgca catggtggcc gcgagcgcgc cgcgctgcgc
    12121 gcgggtggtg cccggcagga gcagtccgag cccggcgagc atgcgggtcc ccggcagcga
    12181 gaggacgttc ggatagccga agagggcgtc cagccggcct tcgccggcgc tgcgccacca
    12241 ctgcggcgcg tgcagtttga gcaccggcca gctcagcagg tcgtcgtcgg cgtgcagcga
    12301 ggacgacgcg agctgttcca gggcgctgat cgtcgcaccg accgaggtgc accgctcgac
    12361 cttgcggaag accgcgtcga tgtcgtcgcg tcgtgtgttg tccacggacc atcctccgat
    12421 gacgggtgcg gtgctccggc gagcgcgcgc tcgccggagc accggtgtcg agacgggcgc
    12481 tcagaacccc tgcgggtggt gagcgagggt gtccccgacc gaacggccgg tgtccagcgc
    12541 ggtgctgggg acggtcgacc cgtggtcgtc gtagccgagt gcgccggcag ccgccgtgag
    12601 gccgacctgc gcggccgtct gtgcggccgt cactccggcg aagacggcgg ccggggtgag
    12661 cagcaccggc agcggctcgt cgctgcgggg tacgtgtcgc tcgccgaact ccgcgtggtg
    12721 ctgggcccag tcggcgatcc gtgtggtccg tgacacagcc atcgctgagt accttcctct
    12781 tctcgtcggt cagaccatga cgtgctcgtc atgcgccggt tcatcccagt gcggacgaag
    12841 ggcgaacgac gtgctgagga attttctaca gcgacagcga tgcgggtacc ggccccgtgg
    12901 gcgcacgaat cgtgatggtt tttttccgat tctttacctt gcgtaacgct gtggcgcgcg
    12961 aagtcttgcg cgcgacggcg cacccgcgat ccgtttcggg gtcgtggcga ccgtcgttgc
    13021 gtgcccgcgc aggggtccgg ctctcctgcc gggccgcaac ttccttacgt cgaaggggcg
    13081 ttggaggagg ctcgggacgg aaaaccaccg cctcccgccc cgcgggcgcg acagccacgg
    13141 gtaagcgggt ttccacgagc cgcgttcacc ggcttccgcg agacggagcc cgcgtcgttc
    13201 cggcccgggc gtacaggagt cggccctgtc tacgcggcag cggtgcagcc gcggcgggcc
    13261 tcacgccact cggcgcggag ccggtcgagc tcgaccaggt ccgccggcgt ccacacggtg
    13321 cgcccggcga cgaagcgccg gatcgcgtcg ttcgcctcgg cggcgtcgag gcgtggttct
    13381 cggtcccttc ctgtgctcat ggtcgacgag cctaacgtcc gtcttttccg tcgacgtcat
    13441 cctgtgggcg gatcaacgac ccttcagggt gggtagtccc gcggagtgcc gtccgcccgc
    13501 ggtcggcgga acctcgcgct ccaccgtacg gtccgccgcc cgtcgacctg cccgacccgt
    13561 cccgaccgag cgcgtgagcg ggcggccctg gtgcggacag ggacaaggaa ggtccgctcc
    13621 ccgcgcccgt caccggccgt cccgtaaggg atcatctacc ggtagcggcc cgggacttcg
    13681 tggaggaccc accgcccggc ccgacaccga ggcgaggagg attccgtgag caaccaggaa
    13741 cgccgcgagc ggtacgcgag ggcgctgtac gccaccctcg ggttcagcgc cgaacggcac
    13801 ccgtgggagg ggctggccgc ggcccggcgg gaggtctggt acgtccgggc cgacgccgcg
    13861 ctcgcgttgg cggacgagga gatcgccgag gcgctggagt ccgagcggca gcgctgaact
    13921 ccgagcagcg tcggccgagg ccctccggct tccggcagag caccgtctcc tccccaggtc
    13981 gcagccgtac tccgcagcga ccaccgacaa ttgaccgatg ccccgtctcc cccgaagccc
    14041 gttcacggcg cccggcgaac agggccgcgg cgtgtggcgc gcgctcgccg aagtcgccgg
    14101 tggcgtgctg ctgatctccc tcggccaagt cgtcgtcagc agtgcggacg agcagctccc
    14161 gctgagtcag tacgccctct ccgtccccgt gctcggactc ttcgccgtcc gccgccgcta
    14221 ccccgtcgtc agcctcctcg gtatcgcggc gctcgcgggc gcgcagcccg ccgccggact
    14281 gcctgccgcg gtcaccgcgt acaccgccac gcggcaactc acggcgccac ggcaccgcac
    14341 ggccctgctg ctcgcctcca ctctcctcgt cctcctgacg agcaccgccc tcgccgcgtt
    14401 cgccggctcc gagggccaga cctccggtcc ggccgtcggc gccgtcctcg ccgccacggc
    14461 gctgctcgta ccgggactcg tcggcacctc ggtgggacag caggaccggc tgatgccggc
    14521 gctcagggaa cgcgccgccg ccgccgagga ggcccgccgg ctcgccgaga gcgagtcgcg
    14581 gatgcaggag cggtcgcgga tcgccgccga gatgcacgac ctcgtcggcc accggctcag
    14641 tctcatctcg ctgcacgcgg gcggcctgga gatggcgctc cgcgacgagt cggccgagat
    14701 gcgcgacgag gcggccctgg tgcgccgggc caccggcgac gcgatgcagg agctgcgcga
    14761 agtcctcggc gtcctgggcc cgttgggccg ggacaccggt accggcgcgc tcaccgacac
    14821 gacgggtacc aggtccgaca tcgaagcgct cgccgaggag tcgcggagcg gcggcatacc
    14881 cgtcgagctc acgtgggagg gcgcggacct cgacgaccgc ccggcccagg tgcgccgcgc
    14941 cgtgcaccgg gtggtccgcg agtctctgac caacgtgcac aggcacgcgg ccggcgccca
    15001 cgtcaccatc aacgtcacgc acaccggcga ccgcgtggag gtgctcgtac gcaacgggcg
    15061 cgcgcccctg caaggtgcgg cgcagcaggg ctcggggcgc ggcctcgtcg gactgcggga
    15121 gcgggtctcg ctgctcggcg gcgagttgga gtcggggccg acgccggcgg gcgggttcgc
    15181 ggtgaccgcg cacatccccg cgcagccgga cccgcacgcc ggcaccgcgg gctcagggga
    15241 cgcacggccg gaaccggccg agcccggtgc cgagcgcgcg ccctcgggtg tccagcgccg
    15301 cgtcgtcggt gcactcaccg ggctgctcgg cctcacgggc gtcagcgtga tgatcctctt
    15361 cggcctcttc ctcgtgagcg aggcgaaccg gacccctcag gccgccgagg aggtcgagcc
    15421 ccggatcggc atgcaccgtg aggagttggg cccgtccctc tgggacgaca cgggggtgcg
    15481 ggcggcagcg acgggacacg agccggcccg ccccgagtcc gcgacggagt gcatctatcc
    15541 gatggtgccg agcgaggact tcctgccgct gagcgagggc gcggggatgg gacccatgga
    15601 gtacgctccc ttcgacgccc aggagggccc gggtcagctc aggatcaccc gatactgctt
    15661 ccacggcgac gagttgaccg cgatcgaccg cttcaacgtg ccggtggtgt cccagacgcc
    15721 atcgtgggag tccccgtgac cgtgcatccc gaccgtccga tccgtgtcct gctcgccgac
    15781 gacgagacga tgatccggca cggcgtccgc ctgatcctgc gccatgcgga ggggatcgag
    15841 gtggtcggcg aggcgagcga cggcgaggag gccgtgcggc tcgccaccga ggcaaagccc
    15901 gacgtcgcac tcatcgacat acggatgccc gtgctcgacg ggctcgccac gatcgacccg
    15961 ctcctcgccc tgcagccccg cccccaggtg gtcatgctca ccaccttcgg cgacgaggag
    16021 aacgtgacgc gcgcgctccg ctccggcgcc accggcttcc tcctcaagga cgaaggcccg
    16081 caggagctca tcagcgcggt gcgctccgcc gccgcagggg acgccgtcct ctcccccggc
    16141 gtcaccggaa ccgtcatcga gcggatgctg agcggtagtt cggacgcggc gagcccgccg
    16201 cgcggcaccg cccccgagca gcagctctcc gagctcaccg gccgggagcg cgacgtgctc
    16261 acgctgctgg gcggcgggct cgccaacgtc gacatcgggc ggcgcctcgg catcggcgtc
    16321 ggcaccgtca agacccacgt cagcgccatc ctggagaaga cgggcaccga cagccgggtg
    16381 caggcggcgg tgctggcgta ccggacgggc ctgctgtcct gaaggactct gcccgaagac
    16441 agagttccgg ataggccccg aggaccacac ggccctgcgg gcccgacctt cgacaggggc
    16501 tccactcggt ccctgaggcc gacggattcg gcgtacggcg cgcggaggat gaggggcagt
    16561 caacctcccc gcccactctg gagccgccat gtcgatgcag gcagccgtat ccgcgtccgt
    16621 ccactcgccc caaagctcgg ccgccgcccg cgccaccgag ctgagcaagg tctacggcga
    16681 gggcgagacc cgagtggtcg ccctcgactc ggtctcgctg gagttcgagc gcggccggtt
    16741 caccgccatc atggggccgt cgggctccgg caagtcgacg ctcatgcact gcatggccgg
    16801 tctcgactcc gtctcgggtg gctcggcgcg gatcggcgac accgagctgt ctcgcctcaa
    16861 cgaccgacag ctcacccggc tccgcaggga cagcgtcggc ttcgtcttcc aggcgttcaa
    16921 cctgctgccg acgctgtcgg cgtcggagaa catcacgctg ccgatgagca tcgccggccg
    16981 caggcccgac ccccagtggc tcgacacggt cgtgcagacc gtcggtctct ccggccggct
    17041 ggaccaccgt cccgcccagc tctccggcgg tcagcagcag cgcgtcgccg tcgcgcgcgc
    17101 cctcgcgtcc cggcccgaga tcatcttcgc ggacgagccg accggcaacc tcgactcccg
    17161 ctccggcggc gagatcctcg ggttcctgcg caactccgta cgggagttgg gccagaccgt
    17221 ggtgatggtc acccacgatc cgacggccgc cgcctacgcc gaccgcgtcg tcttcctcgc
    17281 cgacggccgg ctcgtcgacg agttgttcac gccgaccgcc gagagcgtcc tcgaccggat
    17341 gcggcgcgca ggcaccgcgg gccgcacgga ctgacccggc cgcctgctcc cgccgacccg
    17401 ccgctctcca caccaggacc cctcatgctg cgtacagctc tgcgcaacct catcgcgcac
    17461 aaaacccgac tgatcatgac agcgctcgcg gtcgtgctcg gtgtcgcgtt cgtctccggc
    17521 accctcgtct tcggcgacac cgtgacccgg gcgctccgcg gcgcctccgc cgacaacctc
    17581 aaggacgtcg ccgtctccgt acaggccgag tccgagtggg agtcggagag cgacgcggtc
    17641 gaggaccgct cgacggcgct cacaggcgac ctcgccgaga aggtgaaaga cgtcccgggc
    17701 gtcacctcgg tgcgccccac cgtcaacggc accgccactc tcgccaccaa ggacggccgg
    17761 ccgctcaacg ccgacatgag ctggcagaac ctggcgacca actacgcacc ggacgaccac
    17821 gaccgggaca gccgctaccc cctcagcacc gggcgcgccc ccaccggcga ggacgaactg
    17881 ctcctggagc gccgcaccgc cgagaaggcc ggctacgaac tgggcgacac ggtccgcttc
    17941 gccgtcaacg gcccggcgct caccggccgg ttggtgggca ccgtcgaaac cgacgaccct
    18001 cgcgtcaccg cgggcggaag cctcgtcctc ttcgacacgg acacggcgca gcggctcctg
    18061 ctccagcccg accggttcga cgagctcgcc gtcggctcgg cgcccgggac cgacaaccgg
    18121 cagctcgccc aggaggtctc cgaggtcctg cccgaggaga gcatcacggc caccagcggg
    18181 gccgaactcg ccaaggagca ggccgacgac atcgtccgga gcaccggcga gatgaccaag
    18241 gtgctcatcg ccttcgcggg gatcgcgctc ttcgtcggga tcttcctcat cgccaacacc
    18301 ttcacgatgc tcgtcgccca gcgcagccgc gagaccgcgc tgctgcgcgc cgtaggggcc
    18361 tcgcgccgcc aggtcgtccg tgcggtgctc atcgaggccg ggctcctcgg gctcgtcgct
    18421 tccgccgtcg ggttcgcgct cggcatcggt atcgcgaccg ctatgcggcc gcttctcaac
    18481 atggcgggcg cggggctgcc ggacgggtca ctggtgatct ccgcgggcac gctcgtctgg
    18541 tcgctcgtcg tcggagtcgg ggtcactgtg ttcgccgcgt ggctgccgtc ccggaaagcc
    18601 gcgaaggtgg cgcctgtgga ggcgctgagc accgtcgacc aggcgccgcc gaagcgcagc
    18661 atggtgttcc gcaactccct cggcggcgtg ctcaccggcg cgggagtgct cgtcatgctg
    18721 ctcgtctcca cgcaggaggg cggcgacgac tccaacctcc tggccgccgc cttcggttcg
    18781 gtgctcacgc tgatcggcat gatcgcgctc gccccgctgc tctcccgccc cctggtacgc
    18841 ctcgccggcg cgctcacgtc gcggctgtcc ggtgtgagcg gcatgctcgc cagggagaac
    18901 gccctgcgca acccccgccg caccgctgcc accgcctcgg ccctgatgat cgggctgacg
    18961 ctgatcacgg gcatgagcgt cgtcggcaag tccacccagg ccgccctgga ggacgacgcc
    19021 gtacggggca tgacagccga gtacaaggtc tccgacgccg acttcaacgg gatcgaaccg
    19081 gccctcggcg cgaaggtcga cgacgtcccg ggcgtcacgg cgagcgcgcc cctgacctcc
    19141 tcgaccctga tggccgagga cgagttcgcc accgtcacgg gagccgaccc gaagcgcctg
    19201 gagcgcgtca cggacctgaa gttcaccagc ggctcgctcg ccggggtcgg ccccggcgag
    19261 gtggcgctct ccgaggagta cgccgagaag acgggcctgt cgcagggcga caccttccgg
    19321 gccgagatcg gcgccgagga ctcgcaaaaa ctcaccgtcg ccggggtcta cgagtcgacg
    19381 cgcgtggtcg aggacgtact gggcacctac gacgacgtcc tcccctactc cgagggcggc
    19441 aagctcgaca gcgtcctcgt cggcacggcc cccggcaccg agggcctcga ccaggacatc
    19501 cgcgaggcgc tcggcaacag cccgctcctc caggtgcagg ataaggagca gttgacaaag
    19561 gaggaggccg gcccgatcga cctgctgctc aacatgatgt acgggctgct cggcatgacc
    19621 gtcgtcatcg gcgtgctcgg cgtcgtcaac acccttgcca tgtcggtctt cgagcgcacc
    19681 agggagatcg gcctgctgcg cgccatcggc ctcgacgacc ggggcgtcaa gcagatggtg
    19741 cgcctggagt cggtggtgat ctcgctcttc ggcgcggccc tcggcgtcgg caccgggatc
    19801 ttcctcgcct ggtcgctcgg cagcctcacc ggctcctcgc tcacgacgta cgagacggtg
    19861 ctcccctggg cgcgactcgg cctcttcctc ctgctcgccc tggcggtggg cgtcctcgcg
    19921 gcggtctggc cggcccgccg ggccgtgcgc ctcaacatgc tgcggtcgct caacgcggag
    19981 tagcacgacg gagaaagggg tgccgcggcg tccggccgcg gcacccctct ttctccgtca
    20041 cacggcgtcc cgtcacgccc ccgcggggaa cctctcccag acgcggtggc gttcgaggag
    20101 ggccacgatc tcgtcgagga cgccggtgcc gttggtaccg gtgacgacgc ccggcgcgtc
    20161 ggcggggacg ccggccgcct ccaggacgga ctcggcgccg ccccagaagc cgatcggctt
    20221 cgcgtgccgg aacgcctcgg cgacgagctg cggtacgcgc ccgtccgtac gctcgccgcg
    20281 ggccggcggg ccgaccttcg cgtcgcgggc cgggtagccg tcgcccgcct tcgacggggt
    20341 gccggcgagg aggatcgcgt cgaactcgat cgagcgggcc gtcgtgaacg tgcgctgcac
    20401 ggtgagcgag tcgccgaggg ttccgccctt gggggcgatg acgaggggca ccatgctggc
    20461 ctcgccgatc ctgcgtacga cggcggcgag ttcgtccagg tcgctgccgg ggtcggcgat
    20521 gatgccgacg acgcgcccgt cgaccggcca gc
//
