LOCUS       NZ_KB905458            10393 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Sciscionella marina DSM 45152 A37UDRAFT_scaffold_8.9, whole genome
            shotgun sequence.
ACCESSION   NZ_KB905458
VERSION     NZ_KB905458.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Sciscionella marina DSM 45152
  ORGANISM  Sciscionella marina DSM 45152
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Sciscionella.
REFERENCE   1  (bases 1 to 276736)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Sciscionella marina DSM 45152
            collection_date                   :: SEP 2006
            lat_lon                           :: Missing
            depth                             :: 516 m
            alt_elev                          :: Missing
            country                           :: China
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 45152
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: 19196758
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Sand; Sediment; Marine; Aquatic
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11892
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site :: Marine sand sediment at a depth of about 500 m,
            the northern South China Sea
            Cell Shape                        :: Rod-shaped
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28 C
            pH                                :: 7
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000379465.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 01:37:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,209
            CDSs (total)                      :: 8,146
            Genes (coding)                    :: 7,961
            CDSs (with protein)               :: 7,961
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 1 of 185
            Pseudo Genes (frameshifted)       :: 52 of 185
            Pseudo Genes (incomplete)         :: 155 of 185
            Pseudo Genes (internal stop)      :: 15 of 185
            Pseudo Genes (multiple problems)  :: 34 of 185
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:59:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 93733
            Orig. end                         :: 104126
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905458.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405877
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10393
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10393
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10393
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5393](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5393)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            791..1192
                     /locus_tag="A37U_RS47655"
     CDS             791..1192
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS47655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020502196.1"
                     /transl_table=11
                     /translation="MHKALAGADRAGIWLLRGSSALLLVFLILQGVTAGVVLGGSSAAI
                     ALHSLGAYFVHATALLATLSALWLWRRGRLLWPAVLGAVVLVLTFVQATLGDADVMAAH
                     VPVALLLVGLTVTLLVHACQITTQRTHFR"
     gene            1311..2096
                     /locus_tag="A37U_RS47660"
     CDS             1311..2096
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631920.1"
                     /locus_tag="A37U_RS47660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_020502197.1"
                     /transl_table=11
                     /translation="MRWRSFMALGDSFTEGLDDPADDGGFRGWADRLAELLAAVQPGLT
                     YANLAVRGKVMNDIVTEQLPIALAERPDLVTLCAGGNDLIVPGCDIDALAGRFEDMVAR
                     LTESGADVVVFNGPDPKHMPLMRTVRGKVALYNSHLWSIAGRYGATAIDLWGMRVLGDS
                     RAWADDRLHFTPEGHRRIALRVATALGVPTGQEWNAPWPEQAPLDWFRSRRKDLDWMRT
                     YMLPWARRQLTGRSMGDGVTAKRPSLAPIEVESREHGLA"
     misc_feature    complement(1339..1351)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            2096..2482
                     /locus_tag="A37U_RS0139615"
     CDS             2096..2482
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016152.4"
                     /locus_tag="A37U_RS0139615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_020502198.1"
                     /transl_table=11
                     /translation="MGWGAAEREDARAKLVELAERLPGTEPAHGHGHTGFLVRGKRIAW
                     FLVDHHGDGRLALWVKAPPGEQEALVGTDPVRYFVPAYLGARGWIGVDLYAASPDWDEI
                     AGLLEQAWRMTATKAAIRAFDAAP"
     gene            complement(2479..2865)
                     /locus_tag="A37U_RS0139620"
     CDS             complement(2479..2865)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673062.1"
                     /locus_tag="A37U_RS0139620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_020502199.1"
                     /transl_table=11
                     /translation="MSGFGPGDPFLADCPARLAVELIADKWTVVVLAGLSKGPVRHGEL
                     VEAIGGISRKMLTQTLRRLEAHGLVRRHAHASAPPRVEYELTPLGATLTGPIHALTEWA
                     KANGDAILDALDADSGTVANHGRD"
     gene            2914..3840
                     /locus_tag="A37U_RS0139625"
     CDS             2914..3840
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (16-306). E-value: 3.4e-48.
                     Score: 156.3. Matches aSDomain:
                     nrpspksdomains_A37U_RS0139625_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642408.1"
                     /locus_tag="A37U_RS0139625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_020502200.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-20, bitscore:
                     67.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAITQQTFGGPEVLTIVDAPEPQPLPTEVLVRVRAIGLNPLEAR
                     LRSGEFPLIGQPPFVLGWDLSGVVEQAWTGRFRPGDEVFGMPLFPRAANAYAEFVSAPA
                     LHLAPRPASLSPVEAAALPVAGLTAWQGLVDLGGVTEGDRVLIHGGGGGIGHIAIQLAK
                     ALGARVITTASGSKREFVKGLGADEVIDYQRVDFTETVRDIDLVLDTLGGDTTGRSLAV
                     LRPGGHLVTAVADEDAELAARFEAADMRFSGIAVDPDPFALRGLAELAEQGRLRVHVQE
                     TFPFERVAEAHRLLDDGHLKGKLVLTG"
     aSDomain        2962..3831
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0139625_PKS_ER.1"
                     /evalue="3.40E-48"
                     /label="A37U_RS0139625_PKS_ER.1"
                     /locus_tag="A37U_RS0139625"
                     /protein_end="306"
                     /protein_start="16"
                     /score="156.3"
                     /tool="antismash"
                     /translation="IVDAPEPQPLPTEVLVRVRAIGLNPLEARLRSGEFPLIGQPPFVL
                     GWDLSGVVEQAWTGRFRPGDEVFGMPLFPRAANAYAEFVSAPALHLAPRPASLSPVEAA
                     ALPVAGLTAWQGLVDLGGVTEGDRVLIHGGGGGIGHIAIQLAKALGARVITTASGSKRE
                     FVKGLGADEVIDYQRVDFTETVRDIDLVLDTLGGDTTGRSLAVLRPGGHLVTAVADEDA
                     ELAARFEAADMRFSGIAVDPDPFALRGLAELAEQGRLRVHVQETFPFERVAEAHRLLDD
                     GHLKGKLVL"
     CDS_motif       3268..3312
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A37U_RS0139625_0001"
                     /evalue="1.10E-03"
                     /label="PKSI-ER_m4"
                     /locus_tag="A37U_RS0139625"
                     /protein_end="133"
                     /protein_start="118"
                     /score="12.5"
                     /tool="antismash"
                     /translation="AAALPVAGLTAWQGL"
     CDS_motif       3337..3399
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A37U_RS0139625_0002"
                     /evalue="2.00E-07"
                     /label="PKSI-ER_m5"
                     /locus_tag="A37U_RS0139625"
                     /protein_end="162"
                     /protein_start="141"
                     /score="23.5"
                     /tool="antismash"
                     /translation="GDRVLIHGGGGGIGHIAIQLA"
     gene            complement(4106..4969)
                     /locus_tag="A37U_RS0139630"
     CDS             complement(4106..4969)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441527.1"
                     /locus_tag="A37U_RS0139630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phytanoyl-CoA dioxygenase family protein"
                     /protein_id="WP_020502201.1"
                     /sec_met_domain="PhyH (E-value: 1.3e-26, bitscore: 88.2,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATEVRSEAHDRYPTRITGETHLLERVEPTVWSDEADGPMDAGD
                     LAAHAARGYSIVDGLLSPAEVQAYWSELHRLYVDEGLRSDERLAFDAETGELTSIFAVH
                     EISELFTELVRDPRVLDRARQVLGSEVYVHQSKVTLVPGFTDPGYFWRSEFERWHAEDG
                     MAAPRAVSVSITLADAFASGGAMMLMPGSHRTFVSCGPDKNPPRTDITKLAAEHGIEQF
                     TGQAGAALLADCNVLHGAGSNITPYPRSSIWLAFNSVENPLVEPFSAEARRPEHLASRQ
                     VDTIEY"
     gene            complement(5001..5393)
                     /locus_tag="A37U_RS0139635"
     CDS             complement(5001..5393)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947387.1"
                     /locus_tag="A37U_RS0139635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_026198106.1"
                     /sec_met_domain="ectoine_synt (E-value: 4.3e-55, bitscore:
                     179.1, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLSDIEDTDDDIKSENWRSKRIILAREKLGFSVHETTLYAG
                     TVSDFWYANHIEAVFITQGEGEVENRETGEVFQLKPGTIYVLNNHDKHQVRPKTEIKCV
                     CVFNPPVTGRETHDENGVYPLITEDD"
     gene            complement(5430..6680)
                     /gene="ectB"
                     /locus_tag="A37U_RS0139640"
     CDS             complement(5430..6680)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (22-357). E-value: 4e-73.
                     Score: 238.3. Matches aSDomain:
                     nrpspksdomains_A37U_RS0139640_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084079.1"
                     /locus_tag="A37U_RS0139640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_020502203.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.9e-75, bitscore:
                     247.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIFETFESEVRSYSRGWPVIFDRAKGSYLYEEDGKPYLDFFAGA
                     GALNYGHNNPILKEALLEYISRDGVTHALDMGTVAKREFLESFSERILKPRNLDYKVQF
                     PGPTGANAVEAALKLARKITGKEAIVNFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHS
                     TPMPYDNYFDGTTPDFLFFERLLEDSGSGLNEPGAVIVETVQGEGGINAARIEWLQGLA
                     ELCEKHGMLLIVDDVQMGNGRTGPFFSFEHAGITPDIVTVSKSIGGYGLPMALTLFKSE
                     HDVWGPGEHNGTFRGNSPAFVTAAKALETYWADDELERSTLAKGERLAAALGTLAEENA
                     EAGLLVKGRGLARGLQFPSGDLAAKVCASAFERGLLMETSGPSDEVVKQLPPLTLTEEE
                     LEQGIAIISEAVRSVMG"
     aSDomain        complement(5610..6614)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0139640_Aminotran_3.1"
                     /evalue="4.00E-73"
                     /label="A37U_RS0139640_Aminotran_3.1"
                     /locus_tag="A37U_RS0139640"
                     /protein_end="357"
                     /protein_start="22"
                     /score="238.3"
                     /tool="antismash"
                     /translation="DRAKGSYLYEEDGKPYLDFFAGAGALNYGHNNPILKEALLEYISR
                     DGVTHALDMGTVAKREFLESFSERILKPRNLDYKVQFPGPTGANAVEAALKLARKITGK
                     EAIVNFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHSTPMPYDNYFDGTTPDFLFFERL
                     LEDSGSGLNEPGAVIVETVQGEGGINAARIEWLQGLAELCEKHGMLLIVDDVQMGNGRT
                     GPFFSFEHAGITPDIVTVSKSIGGYGLPMALTLFKSEHDVWGPGEHNGTFRGNSPAFVT
                     AAKALETYWADDELERSTLAKGERLAAALGTLAEENAEAGLLVKGRGLARGLQF"
     gene            complement(6739..7266)
                     /gene="ectA"
                     /locus_tag="A37U_RS0139645"
     CDS             complement(6739..7266)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006238984.1"
                     /locus_tag="A37U_RS0139645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_205623131.1"
                     /transl_table=11
                     /translation="MEGLVTRVSDSSGDTSGVVIAEPTVADGAELWRIARDSGKLDLNS
                     SYAYLLWARDFSATSAVARVDGAIAGFVLGYRRPEAPEALLIWQVAVNARARGRGVAGK
                     MLDHLVQRLAPEVSHLETTVTPDNAASIALFDSFAKRWSADMETNELFASTQFPDEHEP
                     ENLYRIGPLVGR"
     misc_feature    7281..7296
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.55"
                     /tool="antismash"
     misc_feature    complement(7347..7363)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.29"
                     /tool="antismash"
     misc_feature    complement(7353..7367)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.49"
                     /tool="antismash"
     gene            complement(7560..8294)
                     /locus_tag="A37U_RS0139650"
     CDS             complement(7560..8294)
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675290.1"
                     /locus_tag="A37U_RS0139650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_020502205.1"
                     /transl_table=11
                     /translation="MSWSIAVLIAVSGLAAGISGTVTGLGSVFSYPALLAAGIPPAAAN
                     VTNTFSLAIGTVAAVPSSRRELAGQWGAARALGLACVLGSALGAALVLLTPSGAFERVV
                     PFLVGGAALAILAPRPAVHRVRTWPAVLGVFAVAVYGGYFAAAAGVLVLAVLLATRSGS
                     LVRLNALKNLLTLVADVVAAVAFALFGHIVWLAVPPLVFGLLVGSWLGPVIARVLPERL
                     LRYGIALAGAGLAVKLGFDAFG"
     gene            8372..9262
                     /locus_tag="A37U_RS0139655"
     CDS             8372..9262
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020496443.1"
                     /locus_tag="A37U_RS0139655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_020502206.1"
                     /transl_table=11
                     /translation="MIDLRRLRVLRALAEYGTLTAAAHALYLTPSAASQQVRQLGKELG
                     VTLLEPHGRHVYLTPKARELLHHAEAIEQCWEQAQARLHADAPPSGELRVCGITTAVSA
                     LLAPAAVTMRERFPEVRMRIVEAEPPACFDLLFRGAVDLAVTMATPESPPLEDPGFESL
                     PLLEDPYDLLTAPEHPLAGADRVRLADLAREQWVLGMPETAYRQTILALCGTAGFTPDI
                     AHEVFEWSAVAGLAGRGLGIALLPRLVRLPAEPAVVRTPLADPAPSRPLLTVTRRGAGG
                     HPLITAALTVLRELC"
     misc_feature    9986..10000
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
ORIGIN
        1 cgagccacag cggcacgtag accgcgatgc gcagtaggta ctgggcgacc cacaccaggc
       61 tggcgaggca ataggcgcgc accagcgcgg gatccttacg ccagcgggtc ttctggccga
      121 gcaccacgcc gacgatgatc cccagaaacg gccagcgcac cacgatgctg gccagccagg
      181 cgagcgccga tgcggcgttg gagagcaact ggagcaggaa gaaatccgcg gcgcgcccgg
      241 tgtgcagcgc gatcagggcg gcgatcacca cgagcgcgac actcacgatg accgcgcgcg
      301 gtttctcctt gcggatcagc cggagaacgg cgatcaccag ggcgagcccg atcgccgaag
      361 ccgcgccgat ctcgatggac tggcagctcg cgagccatcc gatgacgaac ccgaccggtg
      421 gcaggctcgc gtcgatcgca gcggttcgcc ccccgagcag gctcgcgaac gattcccgcc
      481 gctgctcagt cttagagcac atctgagaac tccatgtcct gctgcgctgc aacgttggcg
      541 aagtaccttc gcatgccagc gcggcgatct gccgcgtcgt cctcaatcac cgcagaaacc
      601 cactgcggct cattcgtccg ccgctgtctc gggtgcgggt gtcccgcagg acacccgcat
      661 ccacgctgac tcccgctcgc gacggacgag agtcctcaga cgcactcttg tccacctact
      721 tagtgtcccc taactcgccc cgttggcacc aatacgcgaa aatcacaccg agaaggcgca
      781 tacttccatc atgcacaagg ctcttgcagg ggccgatcgc gccggtatct ggctgttgcg
      841 cggaagtagc gccctgctcc tggtgtttct gatactgcag ggagtaaccg cgggagtcgt
      901 gctcggtggc tcgagcgctg cgatcgccct gcacagcctc ggcgcctact tcgtccatgc
      961 cacggcactg ctggccaccc tcagcgcgct ctggctgtgg cgccgcggcc ggctgctctg
     1021 gccggccgtg ctcggcgcgg tggtgctcgt cctgaccttc gtccaggcga ccctcgggga
     1081 cgcggatgtg atggccgcgc atgtcccggt cgccctgttg ctcgtcgggc tgaccgtgac
     1141 cctgctcgtg cacgcgtgcc agatcactac gcagcgcaca cattttcggt aacgccgacc
     1201 cgcggattca ccgatacaac ctacggcatg gtaactgacg gtggcgtagc catcggccga
     1261 taaggcatgc tcgccttgat catggcaggc gctcggggag gtgtacgcat atgcggtggc
     1321 gcagtttcat ggcgctcggc gacagcttca cggagggcct ggacgatccc gctgacgacg
     1381 gtggtttccg cggctgggcc gatcggctcg ccgaactgct cgccgccgtc cagcccgggc
     1441 tgacctacgc gaacctcgcc gtgcgcggca aggtcatgaa cgacatcgtc accgagcagc
     1501 tgcccatcgc gctcgccgaa cgaccggatc tggtgaccct gtgtgccggc ggcaacgatc
     1561 tgatcgtgcc cggctgcgat atcgacgcgc tcgcgggccg gttcgaagac atggtcgccc
     1621 ggctcaccga gagcggggcg gatgtggtcg tgttcaacgg tcccgatccc aagcacatgc
     1681 cgctgatgcg caccgtgcgc ggcaaggtcg cgctgtacaa cagccacctg tggtccatcg
     1741 cgggccgcta cggcgcgacc gcgatcgatc tgtgggggat gcgggtgctc ggcgattccc
     1801 gcgcctgggc cgatgaccgg ctgcatttca ccccggaagg gcaccgcagg atcgcgctgc
     1861 gggtggccac ggccctcggg gtgcctaccg ggcaggagtg gaacgccccg tggccggagc
     1921 aggccccgct cgactggttc cgctcccggc gcaaggacct cgactggatg cgcacctaca
     1981 tgctgccctg ggcgcgccgc cagctgaccg ggcgctcgat gggcgacggg gtcaccgcga
     2041 agcggccaag cctcgccccg atcgaggtcg agtcccggga acacgggctc gcctgatggg
     2101 ctggggtgcg gccgaacgcg aggacgcgcg ggcgaaactg gtcgagctcg ccgaacggct
     2161 gcccgggacc gaacccgcgc acgggcacgg gcacaccgga ttcctggtac gtggcaagcg
     2221 gatcgcgtgg tttctcgtgg accatcacgg cgatggcagg ctcgcgctct gggtgaaggc
     2281 gccgcccggt gaacaggaag cgctcgtcgg taccgatccg gtgcgctact tcgtgcccgc
     2341 ctatctcggc gcgcgcggct ggatcggcgt ggacctgtat gccgcttccc cggactggga
     2401 cgagatcgcc gggctgctcg aacaggcctg gcggatgacc gcgaccaagg cggcgatccg
     2461 ggccttcgac gccgcgccct agtctcggcc gtggttggcg accgtcccgg aatcagcgtc
     2521 cagcgcgtcg aggatcgcgt cgccgttcgc cttcgcccac tcggtcagcg cgtgaatcgg
     2581 cccggtcagc gtcgcgccga gcggggtgag ctcgtattcc acgcggggcg gcgctgaagc
     2641 atgagcgtgg cggcggacga gcccgtgcgc ttcgagccgc cggagcgtct gggtgagcat
     2701 cttgcgcgag atgccgccga tcgcctcgac gagctcgcca tggcgcaccg ggcccttgct
     2761 gagaccggcg agcacgacca ccgtccactt gtcggcgatc agctcgaccg ccagccgcgc
     2821 cggacaatcg gcgagaaaag ggtccccggg accgaatccg ctcacgattc caaggtacct
     2881 gccggtacct atcggaaacc taatctgaga gtcatgcgag ccatcaccca gcagacgttc
     2941 ggcggtcccg aggtactgac catcgtggac gcgcccgaac cccagccgct gccgaccgag
     3001 gtcctcgtcc gggtcagggc gatcgggctg aacccgctgg aggcgcgcct gcgctccggg
     3061 gagttccccc tgatcggcca gccgccgttc gtcctcggct gggacctcag cggcgtggtc
     3121 gagcaggcct ggaccggccg gttccggccc ggcgacgaag tattcgggat gccgctgttc
     3181 ccccgggcgg ccaacgcgta cgccgaattc gtgtcggccc cggcattgca cctggcgccc
     3241 agaccggcgt cgctctcgcc tgtcgaggcc gctgcgctgc cggtcgccgg actgacggcg
     3301 tggcagggcc tcgtcgacct cggcggcgtg accgagggcg accgcgtcct gatccacggc
     3361 ggtggcggcg ggatcggcca catcgcgatc cagctcgcga aggcactcgg cgcgcgcgtg
     3421 atcacgaccg ccagcggaag caaacgggag ttcgtcaagg gactcggcgc cgacgaggtg
     3481 atcgactacc agagggtcga tttcaccgag acggtccgcg acatcgacct cgtgctcgac
     3541 acgctcggcg gcgacaccac cgggcgctcg ctcgcagtgc tgcgcccggg cggtcacctg
     3601 gtgacggcgg tcgccgatga ggacgcggaa ctcgccgcca ggttcgaggc ggccgacatg
     3661 cggttcagcg gcatcgcggt cgaccccgat ccgttcgccc tgcgcggtct cgccgaactc
     3721 gccgaacagg gcaggctccg ggtccacgtg caggagacgt tcccgttcga gcgggtcgcc
     3781 gaggcacacc ggctgctcga cgacggtcac ctcaagggaa aactcgtcct caccggctga
     3841 tcccggtcgc cggtgcctgc gggaaagaca taaaacggcc ccgaaccgtt cgctttgaca
     3901 gcggacggca cggggccgta ctccacgtcg gttccacacc gattcggacc ccgagcgtcg
     3961 aaatcggcat ggtcaccgcg aggaactacg gtacgtaact gagccatcgt gttccgtacc
     4021 gtcctgccac cctagcttgc gctatcaggt gatcaacaca gtgccatgcg tgctctaggt
     4081 cacatttagc aggggtacgc acttatcagt actcgatcgt gtcgacctga cggctagcca
     4141 gatgctcagg gcggcgcgcc tccgcgctga acggttcgac cagcgggttc tccacgctgt
     4201 tgaaggccag ccagatgctc gagcgcgggt acggggtgat gttgcttccc gccccgtgca
     4261 gcacattgca gtcggcgagc agcgcggcgc ccgcctggcc ggtgaactgc tcgatgccgt
     4321 gctcggccgc gagcttggtg atatcggtac gcggtgggtt cttgtccggc ccacagctga
     4381 cgaaggtgcg gtgcgatccg ggcatcagca tcatcgcccc gccggaggcg aacgcgtcgg
     4441 cgagcgtgat cgacacgctc accgcgcgcg gtgccgccat cccgtcctcg gcgtgccagc
     4501 gctcgaactc cgaacgccag aagtagccgg ggtcggtgaa cccgggaacc agggtgacct
     4561 tgctctggtg cacgtacacc tcggaaccga gcacctgccg ggcccggtcg agcacccggg
     4621 gatcgcgcac gagttcggtg aacagctcgc tgatctcgtg caccgcgaag atcgaggtga
     4681 gctccccggt ctccgcgtcg aaggccagcc gctcatccga gcgcagcccc tcgtccacat
     4741 agagccggtg caactcggac cagtaggcct gtacctctgc cggggacagg aggccatcga
     4801 cgatcgagta accacgcgcg gcgtgtgccg cgagatcacc cgcgtccatc ggtccgtccg
     4861 cttcatcgga ccagaccgtc ggctcgaccc gctccagcag atgcgtctcg ccggtgatcc
     4921 tcgtgggata acggtcgtgg gcctcgctac gcacttcggt cgcggtcatc gtcgcctggc
     4981 ctcctgtgcc tcgcggactg tcagtcgtcc tcggtgatca gcgggtagac gccgttctcg
     5041 tcatgcgtct cccggccggt caccggtggg ttgaacacgc acacgcactt gatctcggtc
     5101 ttcggccgga cctggtgctt gtcgtggttg ttgagcacgt agatcgtgcc cggcttgagc
     5161 tggaaaacct ctccggtctc cctgttctcc acttcaccct caccctgggt gatgaacacg
     5221 gcctcgatgt ggttggcgta ccagaagtcg ctcaccgtgc ccgcgtagag agtcgtctcg
     5281 tgcaccgaga aaccgagctt ctcccgagcg aggatgatgc gcttgctgcg ccagttctcg
     5341 ctcttgatgt cgtcgtcggt gtcctcgatg tcgctaagcg aacggacgat caactcttcc
     5401 tccaaacgtc gctgtcggct gggctttcgt cagcccatga cggagcgtac ggcttcggag
     5461 atgatcgcga ttccctgctc cagttcttcc tcggtgagcg tcagcggcgg gagctgcttg
     5521 acgacctcgt ccgaaggtcc ggaggtctcc atgagcaggc cgcgctcgaa cgcgctcgcg
     5581 cacaccttcg ccgcgagatc accgctcggg aactgcagcc cgcgagccag cccgcgcccc
     5641 ttgaccagga gcccggcctc ggcgttctcc tcggcgaggg tgccgagcgc ggcggccagc
     5701 cgctccccct tggccagggt ggagcgctcc aactcgtcgt cggcccagta ggtctccagc
     5761 gccttggccg cggtgacgaa ggccgggctg ttgccgcgga aggtcccgtt gtgctcaccg
     5821 gggccccaga cgtcgtgctc ggacttgaac agggtcaggg ccatgggcag cccgtagccg
     5881 ccgatggact tggagacggt cacgatgtcc ggggtgatcc cggcgtgctc gaaggagaag
     5941 aacggaccgg tgcggccgtt gcccatctgc acatcgtcga cgatcagcag catcccgtgc
     6001 ttctcgcaca gttcggcgag cccctgcagc cattcgatgc gcgcggcgtt gatcccgccc
     6061 tcgccctgca cggtctccac gatcaccgct ccgggttcgt tgagcccgct gccggagtcc
     6121 tcgagcagcc gctcgaagaa caggaagtcc ggggtcgtcc cgtcgaagta gttgtcgtac
     6181 ggcatcggcg tggagtgcac gagcgggata cccgcgccac cgcgcttcat cgagttcccg
     6241 gtgaccgaga gcgcgccgag ggtcatgccg tggaaggcgt tcgtgaagtt cacgatcgct
     6301 tccttgccgg tgatcttgcg ggccagcttg agcgcggcct ctaccgcgtt cgccccggtc
     6361 ggccccggga actgcacctt gtagtccagg ttgcgcggtt tgaggatccg ctcgctgaac
     6421 gactcgagga attcccgctt ggccacggtg cccatgtcca gggcgtgggt gacgccgtcc
     6481 cgggagatgt actcgagcag cgcttccttg aggatcgggt tgttgtgccc gtagttcagc
     6541 gcgccggcgc ccgcgaagaa gtcgaggtag ggcttgccgt cctcctcgta cagataacta
     6601 cccttcgcac gatcgaaaat aaccggccag ccgcggctgt agctgcggac ttcggattca
     6661 aacgtttcga aaatattcat ttctttgtca tctgctttct cggattcgca tcgcatgcgc
     6721 catcgcaaac gaatgtgact aacgccctac gagcggaccg attctgtaca agttctccgg
     6781 ttcgtgctca tccggaaact gtgtcgaggc gaatagctcg ttggtttcca tatccgccga
     6841 ccaacgcttc gcgaaggaat cgaacaatgc gatcgatgcc gcattgtccg gggttaccgt
     6901 cgtctccaga tgcgagacct ccggcgcaag gcgttgcacg agatgatcga gcatcttccc
     6961 ggcaacaccc cgtccacgcg ccctcgcgtt gacggcaacc tgccagatca acagcgcttc
     7021 cggtgcctcc ggtcgccgat atccgagaac gaatccggca atcgcaccgt ccacccgcgc
     7081 caccgcggag gtagcggaga aatctcgcgc ccagagcaaa tacgcgtacg aggagttgag
     7141 gtcgagtttt cctgaatcgc gggcgatccg ccacagctcg gcaccatcgg cgaccgtggg
     7201 ctcggctatg acgacgcccg aggtatcgcc actcgaatca ctcactcttg tcaccagtcc
     7261 ctcaatagcc cgcctggcga tgcacgtctt tttcgcacac tgccggggac cgctctccga
     7321 ctcgccagcc gaagctaaca gaaacctgcc cgcaatttca gaaacacgat tcacacacag
     7381 ccgcgctacc agggggaaca aaaacaaccg ggtgatgagg gcgacaaagg tcttcacttg
     7441 acccagggtc acgtgataga ggactgccgg gcgcgcgata ccacgggtgg tattccagaa
     7501 gtcgcgccgg acggcggcag ggcagtagta gacaccacat aacaggtcga gcacaagccc
     7561 tatccgaacg cgtcgaaccc cagtttcacg gcgagcccgg ccccggcgag cgcgatgccg
     7621 tagcgcagca gccgctcggg cagcacgcgg gcgatcaccg ggcccagcca ggagcccacg
     7681 agcaggccga acaccagcgg cggcacggcg agccacacga tgtgcccgaa cagcgcgaag
     7741 gccaccgcgg cgaccacatc ggcgaccagg gtgagcaggt tcttcagcgc gttcagccgg
     7801 acgaggctgc cgctgcgcgt cgcgagcagc acggcgagca cgagtacccc ggcagcggcg
     7861 gcgaaatagc caccgtagac cgcgaccgcg aacacgccga gcacggcggg ccaggtgcgt
     7921 acccggtgca ccgcgggccg gggcgccagg atcgccagtg ccgcaccacc caccaggaac
     7981 ggcaccactc gctcgaacgc gccggacggg gtgagcagca ccagggccgc acccagtgcg
     8041 ctgccgagca cgcaggcgag cccgagcgcg cgcgcggctc cccactgccc cgcgagttcg
     8101 cgccgggagc tcggtaccgc cgccacggtg ccgatggcca gggagaaggt attggtcacg
     8161 ttcgccgccg ccggtggaat cccggccgcg agcagggccg gataggagaa caccgagccg
     8221 aggccggtga ccgttcccga gatacccgcg gcgagaccgg aaacggcgat gagaactgcg
     8281 atcgaccagg acacgacggc cgagtctgcc gccgtgaacc cgccgtgacc aggttcgatt
     8341 tctgaacggt tctgtttaga atcggcagtt gatgatcgac ttgcgccgac tgcgcgtgct
     8401 gcgcgccctc gccgaatacg gcacgctcac cgccgcggcg cacgcgctgt atctgacccc
     8461 ctcggccgcc tcccagcagg tgcgccagct cggcaaagag ctgggcgtca ccctgctcga
     8521 accgcacggg cggcacgtgt acctgacccc gaaggcgcgc gaactgctgc accacgccga
     8581 ggcgatcgaa cagtgctggg agcaggcgca ggcccggctg cacgcggacg cgccaccgag
     8641 cggtgagctg cgggtctgcg gaatcaccac cgcggtctcg gccctgctcg cacccgccgc
     8701 ggtcaccatg cgggagcgct ttcccgaggt ccggatgcgg atcgtcgagg ccgaaccgcc
     8761 cgcctgcttc gacctgctct tccgcggcgc ggtggacctc gcggtgacca tggcgacccc
     8821 ggagagcccg ccgctcgagg accccggctt cgaaagcctc ccgctgctcg aggatcccta
     8881 cgacctgctc accgcgcccg agcatccgct ggccggggcg gaccgggtgc ggctggccga
     8941 tctggcgcgc gaacaatggg tgctcggcat gccggagacc gcctaccggc agaccatcct
     9001 cgcgctgtgc gggaccgcgg ggttcactcc ggacatcgcg cacgaggtgt tcgagtggtc
     9061 cgcggtcgcc gggctggccg gccgcggcct cgggatcgcg ctgctgccga ggctggtgcg
     9121 gctgcccgcg gaaccggccg tggtgcgcac cccgctcgcc gatcccgcgc cgagcaggcc
     9181 gctgctgacg gtgacccgca ggggtgccgg cgggcatccg ctgatcaccg ccgcgctgac
     9241 ggtgttgcgc gagctttgct gacgacgcgg ctcagcgctg actcgtgaag cacagcgtct
     9301 cgtccgcgcg cccgcgcagt tccaggcgcg cgtgctcgga ccagcactcc cgctcccccg
     9361 tactgcactg ctcgatcacc gattcgctgg cgagcacccg ccccgggagc gccttcgccg
     9421 cctcggtgag ccgcgccgcc tcgttcaccg cgtccccgat gacggtgtac tccagcctgc
     9481 tcctggtgcc cagctgaccg gcgaacaccc gcccgcccgc gatcccgatc cccacatcca
     9541 gttccccggc ctcggtgacc gagtcccgga tccggcgcgc ggcccgcagt gcggcgctcg
     9601 ccggatcggc gtgctgcacc ggggcgccga agatgcacag cgtcgcgtcc ccctcgaact
     9661 tgttgaccag cccgccctcc cggtcgatct cggcgacgac tccgccgagc agccggttga
     9721 gcttggccac gaagtcctcg gtcggcaggg cgtaggccag ttcggtggaa ccgatgacat
     9781 ccacgaacag cgccacaacc tcggtgagtt caccgctgag cgaggcaccg acggacatcg
     9841 cgtggtccac gaccgaatcc ccgacatggc gctcgaacag gtcccgcatg cgctcgcgtt
     9901 cgcgcagccc gcgggccaga tcgttcaccg aggcctgcat cagtccgatc tcggtggtgt
     9961 tgttgacctc cacccgggcg tcgaaatcgt ccctggcgat gcgctcgagc gcggtccgca
    10021 tccggcgcag cgggagcccg accgagcggg cgagcagaac cgtgctcgcg atcccgagga
    10081 acaccccgat cccggcgagc acgaacacca cgcggatccg ctcgtcctgg ctcgagcggg
    10141 tgtaggagag cgcgatgacc accgcgacga gcggaacccc gccggagagc acccaggtca
    10201 ccgcgagcct gccgagcacc gttcccctgc gcgcctggta cgactcgagc actcggctca
    10261 tcaccgggcg cagcagccgc tcggtcgcga gataggcgta ggcggtcgtg gtgatcccgc
    10321 cgagcgcgat gaacgcgacc ccggtcgccg cgtcggtata ggagagcagg ctgaacatca
    10381 gcacgctcat cac
//
