LOCUS       NZ_KB905413            22557 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Sciscionella marina DSM 45152 A37UDRAFT_scaffold_39.40, whole genome
            shotgun sequence.
ACCESSION   NZ_KB905413
VERSION     NZ_KB905413.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Sciscionella marina DSM 45152
  ORGANISM  Sciscionella marina DSM 45152
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Sciscionella.
REFERENCE   1  (bases 1 to 34374)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Sciscionella marina DSM 45152
            collection_date                   :: SEP 2006
            lat_lon                           :: Missing
            depth                             :: 516 m
            alt_elev                          :: Missing
            country                           :: China
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 45152
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: 19196758
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Sand; Sediment; Marine; Aquatic
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11892
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site :: Marine sand sediment at a depth of about 500 m,
            the northern South China Sea
            Cell Shape                        :: Rod-shaped
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28 C
            pH                                :: 7
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000379465.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 01:37:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,209
            CDSs (total)                      :: 8,146
            Genes (coding)                    :: 7,961
            CDSs (with protein)               :: 7,961
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 1 of 185
            Pseudo Genes (frameshifted)       :: 52 of 185
            Pseudo Genes (incomplete)         :: 155 of 185
            Pseudo Genes (internal stop)      :: 15 of 185
            Pseudo Genes (multiple problems)  :: 34 of 185
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:59:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7874
            Orig. end                         :: 30431
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905413.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405877
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22557
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..22557
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22557
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12557](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12557
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    607..621
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     misc_feature    991..1006
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            complement(1410..2612)
                     /locus_tag="A37U_RS0129660"
     CDS             complement(1410..2612)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020494669.1"
                     /locus_tag="A37U_RS0129660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="P1 family peptidase"
                     /protein_id="WP_240437712.1"
                     /transl_table=11
                     /translation="MSRERIAMTRPLGPTRARDLGIVIGSGSPGPANAITDVSGVRVGH
                     CTLVGGTGVLVRGRGPVRTGVTVVLPHDKGIWSRPVFAGCHRLNGNGELTGLEWVRESG
                     MLTSPVGLTNSHSVGVVRDALVRAEVAARDPGELFWGLPVVGETWDGVLNDINGFHVCP
                     EHVGHALSAAVGGAVAEGNVGAGTGTICHGFKGGIGTASREIETSGDSRYTLGVLVQAN
                     QGRRDRLSVDGVPVGCHLGPAEVPIPVPPETTVPVEGGGSIIVVVATDAPLLPHQCTRL
                     AQRASFGIARTGGVGEHFSGELVLAFATGNRLRKSEYGADTPGPRPVAMLADGSIDPLF
                     AAAVEATEESILNALVAARSVTGRDGVRAYALPHEGLVAVLEAHGRYTRSFCSALPEET
                     S"
     gene            3331..4338
                     /locus_tag="A37U_RS46030"
     CDS             3331..4338
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS46030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020500307.1"
                     /transl_table=11
                     /translation="MRQRLRRLAPAAGLFLLAPLVGEFLLGNLPIDKLGVLPIFALLYG
                     AGALLIRETVRRTGRGWPAIVLLAAAYALLEEGPVDQLLWNPSYGGRQHTLAGDAYLPA
                     LGTNLSVVQAVLSLHTIWSISVPIALVETFVPTRRTAPWLGRIGLTVTGVLFALGVAAA
                     YSESQRTGQFHATPGQYAGALVVIVALVVLGFAVPYRPHPIDRTAPSPWLVGALTLILT
                     SLLLYLVMFWPGRLSQWVSVAAWCVVAAALAILIGRWSRYRDWGAAHRLGLAAGALLTY
                     TWIAFLHQPVGGLPDPRAQLVDLAGNTVFALLAVALIVLAARAVRRTARTPARY"
     gene            complement(4483..5046)
                     /locus_tag="A37U_RS54025"
     CDS             complement(4483..5046)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025343.4"
                     /locus_tag="A37U_RS54025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_338055095.1"
                     /transl_table=11
                     /translation="MTCPTRCARWSGRTDRLAALLDVLSLDAVTAPDRMPPERAQAILH
                     RHLDTLLTVRTVCNANDSVTDRMETSRSTACTPRNCVYLAGKPCGCTALFMRDMIQIHK
                     IRDSVEFLTCVDAPVTVLLMREWPRRSWTTLRSTPATNTRESRGVGRADRAARASRGTI
                     ARREPHRLARAVNRRTPGTRRGFG"
     misc_feature    complement(5282..5298)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 24.95"
                     /tool="antismash"
     misc_feature    complement(5464..5482)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.07"
                     /tool="antismash"
     gene            complement(5487..6740)
                     /gene="ribA"
                     /locus_tag="A37U_RS0129675"
     CDS             complement(5487..6740)
                     /EC_number="3.5.4.25"
                     /GO_function="GO:0003935 - GTP cyclohydrolase II activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ribA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013675537.1"
                     /locus_tag="A37U_RS0129675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP cyclohydrolase II"
                     /protein_id="WP_240437713.1"
                     /transl_table=11
                     /translation="MTQDRKHAYNELMDRIHMAVAALKSGRPVLVTDAADRENEGDVVL
                     AAHAVTPDWIAWTVRHTSGLLCAPMPPHRAAELALPAMVAYNEDSRGTAYTVTVDAKTG
                     VTTGISAADRARTLQALANPASTSADLTRPGHILPLRARAGGVLERPGHTEASVDLCRL
                     AGVPPVAAIAELVDEDGSMLRGPGVEAVAHRFSLPTLTIAELIGYRQWNPLPTAEDPRV
                     VRTAETELPTRHGHFRALGYLDLRTGADHLVLVRGNPSDETIVRVHSECLTGESLGSQR
                     CDCGPQLDAALERIGRDGGVVVYLRGHEGRAIGLRKKLAAYELQDEGLDTVDANLRIGT
                     PEDAREYGAAAAILRDLNTTHVQLLTNNPDKIRSLEAGGVSVVRRLSLAVGAAPTNIHY
                     LATKHRRMGHLFDNREIS"
     gene            complement(6737..7261)
                     /locus_tag="A37U_RS0129680"
     CDS             complement(6737..7261)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417177.1"
                     /locus_tag="A37U_RS0129680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_240437714.1"
                     /transl_table=11
                     /translation="MAGQFPYIDPFDDGRSPVRRETDMDEASSLIDAVFRFERAVSRIG
                     NVRLRPWNMTLSSYTALRILANQPHLTLAQLSRRCYARPQTMTRMITQLEKRGFVVRGA
                     HPESERAHSLEVTKAGLAALAEMGSAVLKISDTLNSVLGRDDIAAADRQLRQAAQVVEG
                     ESRDEERTDRQ"
     misc_feature    7226..7240
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.82"
                     /tool="antismash"
     gene            7339..7818
                     /locus_tag="A37U_RS0129685"
     CDS             7339..7818
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010228433.1"
                     /locus_tag="A37U_RS0129685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavin reductase family protein"
                     /protein_id="WP_026197736.1"
                     /transl_table=11
                     /translation="MLTKMAFRSTLGHFPSGVVAVTSRDAHGEPVGMAVSSFTSVSLEP
                     PLVAFLPSKSSSTFPIIARRGTFCVNVLAVGQEDICRALAVPGGDKFTRVSWHPGSHDD
                     PVLDGVVAWLGCTITSVHDAGDHDIVVGHVDDLAADGSADPLLFFRSQYHHVAAA"
     misc_feature    7377..7392
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
     misc_feature    complement(7377..7393)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.01"
                     /tool="antismash"
     gene            7852..8841
                     /locus_tag="A37U_RS0129690"
     CDS             7852..8841
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659133.1"
                     /locus_tag="A37U_RS0129690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Ldh family oxidoreductase"
                     /protein_id="WP_020500311.1"
                     /transl_table=11
                     /translation="MTILTLPDARALVTKAMSCAGQSPADADVIADHLLDCEQRGLSFG
                     GLARAVSIVERHRTTHEEPRPIRVVAETSVSATLDGGDQVGYLVGMRALALAMSKARER
                     GIAVVGAHNTWYTGMFSYYLEKAAVAGFSGMIAGSGPGVVAPYGGTEGRFGTNPIAFGF
                     PASPTPVIWDIGTSAVMYGEVALKARLGERLEQGQAYDFDGVPTRDPAAALDGAFAVWG
                     GHKGSGLAMVVQLLGMMSGAAADPPGISDCGFFVLLVDPAVLTDPDDYQDRVTEFAASM
                     RATRPVEGEAGVRVPFDRSVACRAETLRRGTIDVPDAVVTALQKSTSA"
     gene            8982..10004
                     /locus_tag="A37U_RS0129695"
     CDS             8982..10004
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659131.1"
                     /locus_tag="A37U_RS0129695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_020500312.1"
                     /transl_table=11
                     /translation="MVQFFTGLQPLEAGETDPDRMLERVHELDRSQAIDRVLVGYSSTW
                     PHNHATAPFALAATEKFSPIVAHRPGVMPPVAAARYFATLDVLARGRLAINLVVGGSDK
                     DLRRESDDLPKEERYRRAIEYLDVIRRTWTATDQFDHHGDYYAAEAVKIQTKPAQGQVP
                     IFMGGESDNAVDFGARHADLYMLWGEPFAGTKERIERVVAASERYERQMRFSLSLRLFV
                     GDSDDDAWAQARAVEHQIAAASGQFLRSSSTDTSVGRQRALALTEEELHDDCFWTGLTK
                     LLGGFANSQALVGTEERILNTLGTYRDLGIDTFLVTTGAEAAWDPTLEDFLARAKKELG
                     "
     gene            10001..11617
                     /locus_tag="A37U_RS0129700"
     CDS             10001..11617
                     /NRPS_PKS="Domain: AMP-binding (21-426). E-value: 5.2e-85.
                     Score: 277.4. Matches aSDomain:
                     nrpspksdomains_A37U_RS0129700_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417183.1"
                     /locus_tag="A37U_RS0129700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_020500313.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-93, bitscore:
                     304.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTVVSPKELADDTVGGLVAARARTLQDKPALVSGDTELTYGHL
                     DETVSQVARGLLAIGSAPGDSVGILLPNRVEYLLAWFGAARAGLVEVPVNTAYKGMFLD
                     HALRSTAVRVLVTEAGLLELVADLPEPPETLTTVVLLDEVRPSRTLPGVRVLTWRELLA
                     DGECAAELPEVGPADPVAIMLTSGTTGHSKGVVYPNRMQVVAARECTAQMGTTPDERLY
                     TCLPLFHGAAQVNLALHGLYAGATVVLGRRFSASRFWDELRANRVTQFNALGSMLPALL
                     AQPASNSDRDHHAQRAFAAPAPETVLQPFEKRFGVHIVEGYGLTETKNILYNPLSGRRI
                     GSIGLPTASSIVEVHDTSGQPAAPGQAGEIVYRPREPHIMFSGYHHDAEATLATIRDLW
                     WHTGDLGYTDEDGYFYFIDRKKDALRRRGENISSHEVESVLLAYPGVVAAAVVGTPSEL
                     GEDEVLALLQLESGQQLDFAELFSYCDRSMPHFMVPRYYRVLDQLPATPTGKVRKTELR
                     SQGRTGAWDAQLAGLTPTRHA"
     aSDomain        10064..11278
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0129700_AMP-binding.1"
                     /evalue="5.20E-85"
                     /label="A37U_RS0129700_AMP-binding.1"
                     /locus_tag="A37U_RS0129700"
                     /protein_end="426"
                     /protein_start="21"
                     /score="277.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARARTLQDKPALVSGDTELTYGHLDETVSQVARGLLAIGSAPGDS
                     VGILLPNRVEYLLAWFGAARAGLVEVPVNTAYKGMFLDHALRSTAVRVLVTEAGLLELV
                     ADLPEPPETLTTVVLLDEVRPSRTLPGVRVLTWRELLADGECAAELPEVGPADPVAIML
                     TSGTTGHSKGVVYPNRMQVVAARECTAQMGTTPDERLYTCLPLFHGAAQVNLALHGLYA
                     GATVVLGRRFSASRFWDELRANRVTQFNALGSMLPALLAQPASNSDRDHHAQRAFAAPA
                     PETVLQPFEKRFGVHIVEGYGLTETKNILYNPLSGRRIGSIGLPTASSIVEVHDTSGQP
                     AAPGQAGEIVYRPREPHIMFSGYHHDAEATLATIRDLWWHTGDLGYTDEDGYFYFIDRK
                     KDALRR"
     CDS_motif       10544..10588
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A37U_RS0129700_0001"
                     /evalue="2.40E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="A37U_RS0129700"
                     /protein_end="196"
                     /protein_start="181"
                     /score="14.0"
                     /tool="antismash"
                     /translation="IMLTSGTTGHSKGVV"
     misc_feature    11396..11398
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11628..12557
                     /locus_tag="A37U_RS0129705"
     CDS             11628..12557
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417184.1"
                     /locus_tag="A37U_RS0129705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate carboxyltransferase"
                     /protein_id="WP_020500314.1"
                     /sec_met_domain="HMGL-like (E-value: 6.4e-22, bitscore:
                     69.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDEVHIREIAPRLTFQNHLVPTEVKIELVRRLIDAGVRAFELSS
                     FVRPDLIPGLADAEDVFSGIPRVPGLRLGCCVGNTHGLVRAIDAGADAASFLLSADEDF
                     ALANTGRSTTESLSELERMAAYAADYDIVLATYVIFAWGGPTGPARDGAQLEPLARRLL
                     DIGVDHWILADSSGYAAPPQVRELVTTALAHVPAENLTVQIHDTRGMGLAALPSLLELG
                     IRNIDTALAGSGGHPAMPGTPGGGICTEDAIQFLELCGVPTGIHLPRLVDTANWFAEQI
                     GIPNKGFVRHTGPVPRENGATKPLTFTW"
     gene            12585..14051
                     /gene="tcuA"
                     /locus_tag="A37U_RS0129710"
     CDS             12585..14051
                     /codon_start=1
                     /gene="tcuA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417185.1"
                     /locus_tag="A37U_RS0129710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent tricarballylate dehydrogenase TcuA"
                     /protein_id="WP_020500315.1"
                     /sec_met_domain="DAO (E-value: 1.6e-13, bitscore: 41.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKVVVAGAGLAGLTAAISAREAGANVVLLEKGDRTDVGGNAAFS
                     GGLFLFCYDGPADLTSITQDYEAGMWADRIEAPPYTTEAYTDELMAMSNGRADPQLVRA
                     LTNRSLDTVRWLTEKGVRFTFNRTVGAHVREGILHIPPGQILTSTGNGMSRGFEVIKPL
                     VRRAEQLGVEFRWSTPLVEVLRSNGRAVAAAVGDDEPVPADALVITSGGFQANTELRRR
                     YLGPEWENVKLRGTRLATGDGLTAALRAGAGEAGTWASCHSAAVDPTMPSPGCSEAAPP
                     FPLHGFWLGVLVNRDGERFVDEGPGPWVKNYSKMGKAIMRQPGCEAYEIFDQRTAKRVA
                     DEFAGDAVPIVAATVPELAERIGTPADALVRTIKEFNRACQDSRTAKGITPPKSQDATP
                     LDHPPFVAYHAVAGLTFTFGGVRIDPNGRALDPDGVPVPGLYAAGEATGGLFYGDYPGG
                     AALMRAAVFGRAAGRTAAIEGSDSAGLESF"
     misc_feature    12726..12728
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14028..15374)
                     /locus_tag="A37U_RS0129715"
     CDS             complement(14028..15374)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015905.4"
                     /locus_tag="A37U_RS0129715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmgE/PrpD family protein"
                     /protein_id="WP_083933999.1"
                     /transl_table=11
                     /translation="MCGDITGELAGFCVSVATQRMPGDVIVKAKLCLADFLSAALVSSE
                     EARSAVKALGVSGGDEGAAQVLGAATRATAPTAAYLTSVSAAATARTDTHVESSSHPGM
                     VLFPALLALAEQEDVPAGRLLSAVVVGYEVMCRLGSALITPGVAATFRPTGLTGPVAAA
                     AACAHLLALDRHGTQGALGMAASAACGLNEWARAGTQEHVLHSAMAARAGVEAALLARH
                     KLTAARGALEGEAGLLAGFGARHRSSRLIEGLGSGYAIRDIVHKPAPACIYVQGPCQLA
                     EEIVRRHHPDWKRIEAVGIRLPEQAVRYPGCNNSGPVTDVVAAQLSVQFSVASVLVTGG
                     IFDQNWKNLDDLGTKQLAARSRLTVDPHLTKEFPQRNGSHVEVLLDNGSTLVAEQDAFP
                     SMTAVQIVRRFHLAVDPVYGRAGSQAILDCIAGLDRIPLSRLLETLQSG"
     misc_feature    complement(15374..15390)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.58"
                     /tool="antismash"
     gene            15432..16046
                     /locus_tag="A37U_RS0129720"
     CDS             15432..16046
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659128.1"
                     /locus_tag="A37U_RS0129720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NIPSNAP family protein"
                     /protein_id="WP_020500317.1"
                     /transl_table=11
                     /translation="MLYELTNLALKLYTVPKALSTLEDYTTGVAARGRLLGCWEIEHGI
                     IVGRVILLREFQDAVQLTEEREQILASSNPFGIGEYLESFTVESYAQFPFLPPVRTGRC
                     GNVYEIRTYRLKVGGLLPTMSGWEAALPERTKLFPLTTAMYGLDGAPRITHIWPFPSLD
                     ERLTIRRNSYERGIWPPKNGPENITHATSTIALPTAFSPLH"
     misc_feature    15479..15490
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.35"
                     /tool="antismash"
     misc_feature    15534..15536
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15822..15824
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16038..16040
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16193..17221)
                     /locus_tag="A37U_RS50345"
     CDS             complement(16193..17221)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="A37U_RS50345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_157183108.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-15, bitscore:
                     48.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLITAAIFGTSESAPAYAADGQGIRCMNTITPVRLVAHGPAHFQV
                     HGRLCLPSSGQTRTVQLLVPGGAYDHSYWDFPYRPERYSYVRAMAESGKATFTIDPIGS
                     GRSSLPLGASVTLSAVARTVHQLIRDLRGGAIGDRSFRKVVLEGHSVGSAVAWVEAATY
                     RDIDGLIVTGMMHPNPLLPITLRAIVGLGTSVQPAMLDPKFRYVLDPTYITTRPGTRAG
                     LFYNPADTDPEVPVVDEQTKATLPLPEMAFPVHQLDGLTRHINVPTLVVEGGKDKFFCA
                     GLGGRDCSSGQAIRRHEAPYYGPGAQLQGYVLPNAGHCINLERNAQEWYRAASRWIDTA
                     VH"
     misc_feature    complement(16481..16483)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17760..18542)
                     /locus_tag="A37U_RS0129725"
     CDS             complement(17760..18542)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020415886.1"
                     /locus_tag="A37U_RS0129725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_020500318.1"
                     /transl_table=11
                     /translation="MPTDRERTDGGSVQVVRKSAQILDCFSATTPRLRAADIVQATGMP
                     TSTVARILRTLVGENLLQRQRQEYSIGLRVTAWSAAAKAGSDLLAAAGPHITALRDRSR
                     ESCGIYVRQGTNRVSVLGAESTHSIIYRGYIGQILPLQAGAAGKVLMAYDEQAHQAALE
                     EGLPGYTEYSITDPQVLEKLLDQVRKQGWAFTEEEREPGLNSLAAPVFGAGRTLVAAVA
                     MGAPSFRLTRAVAEKLAADITATAAAISRALLASEPEQ"
     misc_feature    complement(18667..18681)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.95"
                     /tool="antismash"
     gene            18711..19580
                     /locus_tag="A37U_RS0129730"
     CDS             18711..19580
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020415885.1"
                     /locus_tag="A37U_RS0129730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="isocitrate lyase/PEP mutase family protein"
                     /protein_id="WP_240437716.1"
                     /sec_met_domain="PEP_mutase (E-value: 6.7e-50, bitscore:
                     160.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIRSRLRELLAERSAVVAPGVFDGLSAALTVSAGFRAAYLSGA
                     AVAAANGLPDVGLATQTEFVQLLALVSGRMDVPVIADADTGFGDVTHAYRTVQLYERAG
                     AAAIQLEDQEFPKRCGHIDGKRVVDAEEFARKIEAAAQARRDPETVLIGRTDACAVHGF
                     DEAVRRGNLYAEAGADLVFLEAPGTFDQVRRVPAEVTAPALFNLVPRGKTPQVELAELA
                     ELGYALVIMPGLCVGSAAAAMRAALERAARGDVGTDGQDSPRGLFDALGLSFWEDLRES
                     YAGQAADA"
     gene            19573..20823
                     /locus_tag="A37U_RS0129735"
     CDS             19573..20823
                     /EC_number="4.2.1.33"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020415884.1"
                     /locus_tag="A37U_RS0129735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aconitase/3-isopropylmalate dehydratase large
                     subunit family protein"
                     /protein_id="WP_020500320.1"
                     /transl_table=11
                     /translation="MPETLIQKVLGRASGGQAEVGEIVVCEVDLTALIDIQFAHDRLAD
                     VVSVADPDRIMIVFDHAVPAPSIRDAESGRKARAFAAEHGIRKLFDLGQHGIVHQVLAE
                     QGLARPGWVVACTDSHTCAAGAVGAAARGLGPAEVLQIVCTGRTWHQVPPTVHYALSGR
                     KSPWVNGKDIFLHIAGRYGDATGHAVEFGGPGLAELPMADRRTIATQGAEIGADFTIFP
                     ADQHCLDYVTAAAPDAEPAPVRPDEDAEYAAVRGIELSGISPMVARPGTVIENAGPVGD
                     LVGTRIDQAFIGSCANGQLADLEVAAEILKGQQVASGTRLIVTPASQRIYLEASRRGLL
                     ADLVEAGATVTNPTCGACFGYHMGTLAAGEVCITASTRNFKGRMGSTEAEVYMASPATV
                     AASAIRGVISDVREVVG"
     gene            20820..21320
                     /locus_tag="A37U_RS0129740"
     CDS             20820..21320
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02087.1"
                     /locus_tag="A37U_RS0129740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020500321.1"
                     /transl_table=11
                     /translation="MNQVSGRAWVFGDGINTDDMYPGFAMRLPIEEAARHMFHASRPEW
                     PQLVHPGDVVVAGRNFGLGSSRPVPLLFRELGVAALVAEQFNSLFFRNCINYGLPAATL
                     PSATRLIREGETVLIDFTDGSLRVGETVHPIAPLPELLRAVLDAEGLLRQLELDGKLRP
                     GKG"
     gene            21323..22459
                     /locus_tag="A37U_RS0129745"
     CDS             21323..22459
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016210.4"
                     /locus_tag="A37U_RS0129745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PrpF domain-containing protein"
                     /protein_id="WP_026197738.1"
                     /transl_table=11
                     /translation="MSDQETVRCVLMRGGTSKGVYFHESDLPKPGPRRDRLLKRLMGTP
                     DVLQIDGLGGSRPITSKVAIIAPSARDDADVDYTFAQVSIDEDEINYTGNCGNISSGVG
                     PFAIDEGIVPAVDEITEVRIHNTNTGKILVAHVPVGDGKSKVDGDFALPGVPGTGAEIV
                     MDWSGTVGAKTGKLLPTGCPVDDIELSDGTCVAATICDAGNPAVWAHAEDFGLTGSELS
                     AEINENTALIDRVRELRGRAAVLAGLCTDWRAVDTQSPGIPLAGLVAPPAGYTTLNGAD
                     IAARDMDLRVRLLFMNRLHESIAGTASICLTAASRVPGSVPGKVGANRTDGLLLAGHPS
                     GVTPVRVEGSSVHFGLLGFSRTARRLMDATAYYPRSTF"
ORIGIN
        1 ctgcgtgatg agctcggtca ggtgtggatc cttctgctgg aatcccaccg cgaacggggc
       61 cagctgcggg ctccagttgc gcatcgccat cagcggaccc ccgaacgcgg cgtagtacgt
      121 gacggtggcg tccatctgtg ccggcacaga cacccaggcc cgctggttga gcacgccttc
      181 ttcgagctgg gtggccacca cggtcacgcc gatctcggcg aggctctgct ggatgatctg
      241 ggtgatggcg ccaccgacgg tgtcgccagc ggtggcaccg tagatgatct cgaatcgcag
      301 gttggggtga ccggcttcgg ccagcagcga cctggcccga tcgggatcac gacgcagcga
      361 agacggtatc gcccccggaa aggctgccga caccacaccg gtgacctcgc cggcgtccgc
      421 aagggcgacg cgccggatct tctcgcggtc gatgccacaa gcgatggcct gccggacccg
      481 gggatcggcg aagggggtag cgccgcaggc gttcagggtc aggacgaaga agtcggtgca
      541 ttgctgcacc cgcacggcga ggttcgggat gctcgacagc agcaggggcg cgtcgggctg
      601 gtcgaaatcg gcgatgtcga tgctgccgtt gccaagggcg gcgatccgcg agttcacgtc
      661 cggcatgatc gggatgacaa ggcggtccgc ggccggcgaa cgccaggcgt gcggattgcg
      721 gaccaggacc cagcgttgat cctgctcgtg gctttgcacc aggaacggtc ccgtgccgag
      781 catctcggta gtcgggtcga gcccgccggc gtcgatctcc ttcatcggca ggatcaccgc
      841 agacgcagcg ctgagcgcgg acaggaacgt gcggctgggc gcggcaagcc tgaaccgcac
      901 cgtccggtcg tcgagcttgc tgaccgtggt gctcgggccg ccgatgaaac tggcgaacga
      961 tgtcgggttc tccggatcga gatgtcgccg gaaggtctcg accacatcat cggcggtcag
     1021 cgggcggccg tgggagaaca cggcatcggg acgcagcgag aagacgtact cggtcggcga
     1081 gggagtctgc cagctctgcg ccagcgccgg cactacgttc aggttgtcgt cgagctcgac
     1141 cagcgggtcg tagatcacct ggatcaggtc ccacgaggaa cccaggttcg acttcggcgg
     1201 atcgagcgcg atggcttcag cactcttacc ccagatgacc gtgccgcccg gtactgcggt
     1261 ggcgggcccg ataccgccac cgacctcggc gcgcctcgcg caccccgaca gcaccccggg
     1321 aaccgcgata ccggcccctc cggtgagcag cgcacgcaac acggctcgac gaccgacgcc
     1381 agtgcttccg gatggaggaa ccggggctgt cacgacgttt cctcgggcag cgcagagcag
     1441 aaggaacggg tgtatcggcc gtgcgcctcg agcaccgcga cgagaccctc gtgcggcagc
     1501 gcataggcgc ggacaccgtc acgaccggtc acagaacggg cagccaccag cgcattgagg
     1561 atcgactcct cggtggcctc cactgcggcg gcgaacagcg ggtcgatact cccgtcggcg
     1621 agcatcgcca ccggccgggg cccgggagta tcggcgccgt actcgctctt acgcagcctg
     1681 ttaccggtgg cgaaggcgag cacgagctcg ccgctgaaat gctcgcccac ccctccggtg
     1741 cgagcgatcc cgaacgacgc ccgctgcgcg agacgggtgc actgatgcgg gagcaacgga
     1801 gcatcggtgg ccacgaccac gatgatcgag ccgccgccct cgacgggcac ggtcgtttcc
     1861 ggcggcaccg gaatcgggac ctccgccgga ccgagatggc acccgaccgg aaccccatcg
     1921 accgacagcc tgtcgcggcg gccctgattg gcctggacca acaccccaag cgtgtaccgg
     1981 ctgtccccgc ttgtctcgat ttcgcgagag gccgtgccaa tgccgccctt gaaaccatgg
     2041 caaatcgtcc cggtgcccgc accgacgttg ccctcggcga ccgcaccgcc cacggcagca
     2101 ctcagggcgt gccccacgtg ttcggggcac acgtggaagc cgttgatgtc gttcaggaca
     2161 ccatcccaag tctcccccac caccggcaga ccccagaaca gttcaccggg atcgcgtgcc
     2221 gcgacctcgg cccgcaccag cgcatcgcgc accaccccga cgctatggga attggtcaga
     2281 ccgacaggcg aggtcagcat cccactctcc cgcacccact ccagcccggt gagctcaccg
     2341 ttgccattga gccggtgaca ccccgcgaac accgggcgac tccagatccc cttgtcgtgt
     2401 ggcaggacga ccgtgacgcc cgtgcgcacc ggcccccgac ccctgaccag cacgcccgtc
     2461 cccccgacga gcgtgcaatg ccccacccgg accccggaga cgtcagtgat cgcattagcg
     2521 gggcccggcg agccactgcc gatgactatg ccgagatccc gtgcacgcgt cggacccaga
     2581 ggtcgcgtca ttgcaatcct ctcacgactc aagccgtcat aacttgagca agtgtacaaa
     2641 gatagctcgg ccgcctgtca agaccatcgg gaataaagcg caaagatgat cacggcgaca
     2701 ggggtatcag aactggacgg tcaatcaaag tatcggtgag tacaggccgc cggttgccgt
     2761 atggcagagc cctggcccga aggccgccga cgcacatggc cgcgatcggc ctcgggcaag
     2821 cgaacgccat gccgccgatg ggcggacgat gtttcgaaca tgccgatcgt gaacgaagac
     2881 caacgaatga tccggcttct ccctcgacga aaccgtgtcc gtgccgacct tcggaagcct
     2941 cctcgtctcg acaccgagtc cagcggatcg acaccgccgc cgcatccggc acgttctcaa
     3001 ccggcttcct cgctcgaccg ctgccaggat gtgcgggacg aaccccgcga gcaccactcc
     3061 gcacgcaccg tcgggcctgc ccagcgccgc agcttccagc acgcgcccgc gcaaccgcgg
     3121 cagcccgaga gcatcgagcc cagcgacgtc tcggagccaa tcaccagcca cgatctcgcc
     3181 atcagtgccg agcacctcgg ctaccgcgat cgaaacagca cctcgcccgg cacaaaggac
     3241 cgctgcgata aaggaatacg gagcgcccgc tgcttcggtc ggtgtcgtgg tcggttgcgc
     3301 tggatcggtc gggattatta gcgtccgggc atgcgtcagc gactacgtcg actcgcgccc
     3361 gcggccgggc tgtttctgct cgccccgctg gtgggcgagt tcctgctcgg caacctgccg
     3421 atcgacaagc tcggcgtgct gccgatcttc gcgctgctct acggggcggg cgcgctgctg
     3481 atccgcgaaa cggtacgacg caccggccgc ggctggcccg cgatcgtgct gctcgccgcg
     3541 gcgtacgcgc tgctcgaaga gggcccggtc gaccaactgc tgtggaaccc ctcatacggc
     3601 ggaaggcagc acacactcgc cggcgacgca tacctcccgg cactcggcac gaacctctcg
     3661 gtggtgcagg ccgtgctctc cctgcacacc atctggagca tcagcgtgcc gatcgccctg
     3721 gtcgagacgt tcgtgccgac gcgtcgcacg gcgccctggc tgggccgtat cgggctgacg
     3781 gtcaccggcg tcctgttcgc cctcggcgtg gccgccgcgt acagcgaaag ccagagaacg
     3841 ggacagttcc atgccacccc tggccagtac gccggtgccc tggtggtgat cgtcgcgctg
     3901 gtcgtgctgg gcttcgctgt cccctaccgg ccgcacccga tcgaccggac ggcaccgagc
     3961 ccatggctgg tcggcgcgct caccctgata ctgaccagcc tgctgctcta cctggtgatg
     4021 ttctggcccg gccgcctgtc ccaatgggtg agcgtggccg cctggtgcgt cgtggccgcc
     4081 gcgctagcca tcctgatcgg gcgctggtcc cgctaccgcg actggggcgc cgcacaccgg
     4141 ctcggcctgg ctgccggcgc acttctgacc tacacctgga tcgcgttcct ccaccaaccc
     4201 gtcggcggcc tcccggaccc gcgtgcccag ctagtcgatc tcgccggtaa cacggttttc
     4261 gcgctcctgg cggtggcgct gatcgtgctc gccgcccgag ccgtccgccg tacagcgaga
     4321 accccggctc ggtactgagc agcgggcagc gcgacagcgg tagcggctgg tttgccgggt
     4381 tccgcgacct cgcagcgggc accgcgggcc tcatcggact cctcaatccc gtcaccggcg
     4441 tgtgctccgt ggcaccctca tcaccggtcg ctcccccgac gatcaaccaa accctcgcct
     4501 tgttccaggg gtacgtcggt ttactgcccg ggcaagccga tgcggctcgc gtcgtgcgat
     4561 ggttccacgc gaagctctcg ctgccctgtc tgcacggccc accccacggg actccctcgt
     4621 gttcgtcgcc ggagtcgacc gcaaagtcgt ccaagaacgt ctcggccact cgcgcatcag
     4681 cagcacagtc actggagcat caacgcaggt aaggaattcg acgctgtcac ggatcttgtg
     4741 gatctggatc atgtcccgca tgaagagagc ggtgcatccg caaggcttac ctgccaagta
     4801 cacacagttc cttggcgtac atgcggtact gcggctcgtc tccatacgat cggtgacaga
     4861 gtcgttcgcg ttgcacaccg tgcgaaccgt gaggagtgtg tcgaggtgcc tgtgcaggat
     4921 cgcctgcgcg cgttcgggtg gcattcggtc gggtgcggtc acggcatcca ggctgaggac
     4981 gtcgagcagt gcggccaacc ggtcggttct gccggaccac cgtgcgcagc gagtcggaca
     5041 ggtcacgcgc gtagggccgg agagtgtcgt tggtgcgtgc tgcggtggtg aaggccagcc
     5101 acacgctcgt ctcttctctc agccgccggc ggtcctgtgg tgactcggca atgcggaggt
     5161 tgtcgacgtg tgctggcaca cgggcgttca ccgcgtcgtt cagtgcctgc tgcgcgaaaa
     5221 gcatcagccc gtcgtggtcg gcgaagtagt gcctcaccga gccgatcgcc agtccggcct
     5281 ccgccgcaac attgtgcagt gatgccgcgt ggagtccgtg gcggagcacg acgcggaaca
     5341 ccgctttggc gatgccctgg cgccgggctt cgggatcgac gagctcgggc acagtgctcg
     5401 ttccgttgtc gggccttagc gggccggcgc cgccagcgga gcaatcagtc gtctgaaata
     5461 agttctgaga gccgctatca agtcgctcag gaaatctcgc ggttgtcgaa gaggtggccc
     5521 atgcggcggt gtttcgtagc gaggtagtga atgttcgtag gagcagcgcc gacggctagg
     5581 gaaaggcggc gcaccacgga aactccaccg gcttccaagc tacgaatctt gtcgggattg
     5641 ttggtcagca gctggacgtg ggtcgtgttg agatcacgta gtatggctgc cgctgccccg
     5701 tattcgcgcg cgtcttccgg tgtgccgatg cggaggttgg cgtccactgt gtccagtccc
     5761 tcgtcctgaa gttcgtacgc ggccagcttc tttctgagcc cgatggcccg accttcgtgt
     5821 ccgcgcagat acaccaccac cccaccgtcc cgcccgatgc gctccagtgc ggcgtcgagc
     5881 tgcgggccgc agtcgcagcg ctgcgagccg agtgattcac cggtaaggca ctcggagtgg
     5941 actcgcacga tggtctcatc gctcgggttt ccacgaacga gcacgagatg atcggcaccc
     6001 gtgcgcaggt cgagatagcc tagtgcgcgg aaatgtccgt gtctggtggg tagctcggtc
     6061 tccgcggttc gcaccactcg cggatcctct gcggtcggca gggggttcca ttgacggtag
     6121 ccgatcagtt cggcgatcgt gagcgtcggc aagctgaacc ggtgcgcgac ggcctcgacc
     6181 ccgggacctc gcagcatcga gccgtcctcg tccacgagtt ctgcgatagc cgcgaccggc
     6241 ggcacaccgg ccagtcggca taggtcgacc gatgcctccg tgtgccctgg ccgctcgagg
     6301 acacccccgg ctcgtgcccg cagcggcagg atatgaccgg gacgggtgag atcagcactc
     6361 gtgcttgcgg ggttcgcgag tgcctggagg gtacgcgcac ggtctgcagc gctgattccg
     6421 gtggtgacac cggtttttgc gtctacggtc acggtgtagg cagtgcctcg agagtcctcg
     6481 ttgtacgcca ccatcgctgg cagcgccagc tccgccgcgc gatgcggggg catcggcgcg
     6541 cacagcagcc cggaggtgtg ccggacggtc caggcgatcc agtctggcgt caccgcgtgc
     6601 gcggcgagta cgacatcacc ttcgttctca cggtcggcgg cgtcggtcac aagtaccggc
     6661 cggccggact tcaaagcggc tactgccatg tgaattcgat ccataagctc attataagca
     6721 tgcttacgat cctgggtcac tgcctgtccg tgcgctcctc gtcgcgcgac tcaccttcaa
     6781 ccacttgcgc cgcctgtcgc agctgacggt cagcggccgc gatgtcgtct cggccgagta
     6841 ccgagttgag cgtgtcgctg atcttgagca cggcgctccc catctccgcg agcgcagcaa
     6901 ggccggcctt ggtgacttcg agcgagtggg ctcgctcact ctccggatgc gcgccgcgga
     6961 cgacgaaacc gcgtttctcc agttgcgtga tcatgcgcgt catcgtttgc ggacgggcat
     7021 agcaacggcg ggacagttgg gcgagcgtga gatgcggctg attggccagt atgcgcagcg
     7081 cggtgtaact ggacagtgtc atgttccacg gccggagtcg cacattgccg atccgcgaga
     7141 ccgcacgctc gaatcggaac acggcgtcga tcagggaaga cgcctcatcc atgtcggttt
     7201 ctcgtcgcac gggcgagcga ccgtcatcaa acgggtcgat ataaggaaac tggcctgcca
     7261 ctcccacagt gtagtggtag cgcgcggacg ggtcttcagt atgttgcttg accaaaagag
     7321 tgcttgtatc atgtcagcat gcttacaaaa atggcgttcc gatcgacgtt ggggcatttc
     7381 cccagcgggg tagtcgccgt caccagtcgt gacgcgcacg gcgagccggt ggggatggct
     7441 gtctcgtcgt tcacctcggt ttcgctcgaa ccccctttgg tggcattcct gccttccaag
     7501 tcgtcttcga cgtttccgat catcgctcgg cgcggcacct tctgcgtcaa cgtcctggcc
     7561 gtcggccagg aagacatctg ccgcgccttg gccgtgccgg gcggggacaa attcacccgt
     7621 gtgagctggc accccggatc acacgacgat cccgtgctcg atggtgtcgt ggcctggctc
     7681 ggttgcacga tcacctccgt gcacgacgct ggcgaccacg acatcgtcgt gggccacgtt
     7741 gacgacctgg ctgccgatgg ttcagcggac ccactgctgt ttttccgcag ccagtaccac
     7801 catgtcgctg ccgcttgatc tcaaccctgt cacatccgcg gaggccggtt catgaccatt
     7861 ttgaccttgc ccgatgcccg cgctctcgtg acgaaggcga tgtcctgtgc cgggcagtca
     7921 ccggcggacg ccgacgtcat tgccgatcat ctgctcgact gtgaacagcg aggcttgtcg
     7981 ttcggcgggc ttgcacgcgc ggtgtctatc gtggaacgtc accggaccac acacgaagaa
     8041 ccgcggccga tccgcgtcgt tgccgaaacc tcggtctcgg caacgctcga cggcggcgac
     8101 caggtggggt acctcgttgg catgcgagcg cttgcgctgg cgatgtccaa ggctcgcgag
     8161 cgcgggatag ccgtagtcgg tgcccacaac acctggtaca cgggaatgtt ttcctactat
     8221 ctggagaaag ccgccgttgc gggtttctcg gggatgatcg caggcagcgg acctggcgtg
     8281 gtcgctccgt acggtggtac cgaaggccgg ttcggtacga accccatcgc gttcggtttc
     8341 cccgcgagcc cgacgccggt catctgggac atcggcacat ccgctgtcat gtatggcgag
     8401 gtggcgctga aagccaggct cggcgaacgc ctggaacagg ggcaagcgta cgacttcgac
     8461 ggcgtcccga cacgcgatcc tgctgccgct ttggatggcg cgttcgccgt ctggggcgga
     8521 cacaaaggtt ccgggctggc catggttgta cagctgctcg ggatgatgag cggtgcggct
     8581 gctgacccgc ccggcatctc cgactgtggc ttcttcgtgc tgttggtcga cccggccgtg
     8641 ctgaccgatc cagacgacta ccaggacagg gtcaccgaat tcgccgcgtc gatgcgggca
     8701 acgaggccgg tcgaaggcga ggcaggggtc cgagtgccgt tcgatcggtc cgtggcctgc
     8761 cgtgcggaga cgcttcgacg cggcacgatc gacgtgcccg acgccgtggt cacggcactt
     8821 cagaagtcga cgtccgcctg agcatacaca cgacctcgcg atcaaaccgt cccgaacgac
     8881 ccggtgcccc gcggctgcgc ccaggcggag tcgcgcatcc ggcaccccga ccatttcacc
     8941 aggcaccaga cctggttggc agacaatcaa aggaggacac catggtccag ttctttaccg
     9001 ggctccagcc cctcgaggcc ggcgagaccg acccggaccg aatgctcgag cgggtccacg
     9061 aactggaccg gtcgcaggcg atcgaccggg tactggtcgg gtactcctcg acctggccgc
     9121 acaaccatgc gaccgcgccc tttgcgctcg cggcaaccga gaaattctcc ccgatcgtcg
     9181 cccatcggcc cggtgtcatg ccgccggtgg cagcggcacg atacttcgcg accctggatg
     9241 tgttggcgcg cggacggctc gctatcaacc tcgtcgtcgg tgggtccgat aaagacttgc
     9301 gccgcgagtc cgacgacctg cctaaggagg agcgctatcg gcgcgcgatc gagtaccttg
     9361 atgtgatccg ccgaacctgg accgcaaccg atcagttcga ccaccatggc gactactacg
     9421 ccgcagaagc ggtgaagatc caaacaaagc ctgcgcaggg gcaagtgccg atcttcatgg
     9481 gcggggagag cgataacgcg gtcgacttcg gcgcgcgtca cgcggacctg tacatgctgt
     9541 ggggggaacc gttcgcgggc acgaaggaac gcatcgaacg ggttgtcgct gcatccgaac
     9601 gctacgagcg gcagatgcgg ttctcgctga gcctacggct gttcgtcggc gattccgacg
     9661 acgatgcctg ggcgcaagcc cgtgcggtcg aacaccaaat cgcggcagcg agtggccagt
     9721 tcctccgttc ctcctcgacc gacacttcgg tggggcggca gcgggcgctg gcgttgaccg
     9781 aggaggagct gcatgacgac tgcttctgga ccgggctgac gaaattgctc ggtggtttcg
     9841 ccaactccca agcgctcgtc ggcaccgagg agcgcatcct gaacacgttg ggcacctacc
     9901 gtgatctcgg catcgacacg ttcctggtga ccacaggcgc cgaggcagcc tgggacccga
     9961 cgctcgaaga cttcctggcc cgggcgaaga aggagctggg atgacccgga ccgtcgtgtc
    10021 acccaaggaa ctcgcggacg acaccgtcgg tggtctcgtc gccgcacggg cccggacact
    10081 ccaggacaag cccgccttgg tgtccggcga taccgaactc acctacggtc acctggacga
    10141 gaccgtttcc caggtggccc gcggcctgct cgcgatcggt tccgcgccgg gcgactccgt
    10201 cggcatcctg ctgcccaacc gtgtcgagta tctgctcgcc tggttcggtg ccgcccgggc
    10261 agggctggtc gaggtgccgg tcaacaccgc ctacaagggc atgtttctcg atcacgcgct
    10321 gcgcagtacc gccgtgcggg tcttggtcac cgaggccggc ctcctcgagc tcgtcgccga
    10381 ccttcccgaa ccacctgaaa cgctcacgac ggtggtcttg ctggacgagg tcaggcccag
    10441 ccgcacgctg cccggcgtca gagtgctgac ctggcgtgag cttctcgccg acggcgaatg
    10501 cgcagccgag ctgcccgagg tcggcccggc ggatccggtg gcgatcatgt tgacctccgg
    10561 cactaccggc cacagcaaag gagtcgtcta ccccaaccgc atgcaagtgg tcgccgcccg
    10621 agagtgcaca gcgcaaatgg gcaccacccc cgatgaacgg ctttacacat gcctgccgct
    10681 gttccacggt gctgcgcagg tcaatctcgc tttgcacggc ctgtacgccg gtgcgaccgt
    10741 ggtactcggc aggcggtttt ccgcgagccg gttctgggac gagttgcgcg cgaatcgcgt
    10801 cacccagttc aacgcactcg gctcgatgct gccggcactc ctcgcgcagc cggcctcgaa
    10861 ctccgaccgc gaccaccatg cgcagcgtgc gtttgccgcc cccgccccag aaacggtact
    10921 ccaaccgttc gagaaacgct tcggtgtgca catcgtcgaa ggctacggac tcaccgagac
    10981 caagaacatt ctttacaacc cgctgtcagg gcgcaggatc ggctcgatcg ggttgcccac
    11041 agcatcatcc atcgtcgagg tccacgacac gtccgggcaa ccagctgcgc cgggccaggc
    11101 gggcgaaatc gtctaccgcc cccgtgagcc gcacatcatg ttttccggct accaccacga
    11161 tgccgaggcg accctcgcga cgatccgcga tctgtggtgg cacacagggg atctcggcta
    11221 caccgacgag gatggctact tctatttcat cgaccgtaag aaagatgcgc tgcgccgccg
    11281 cggcgagaac atatcctcgc acgaggtcga atccgtactg ctcgcctacc caggagtcgt
    11341 cgccgccgcc gtcgtcggca caccctcgga actcggtgaa gacgaggtac tggccttact
    11401 acagctggaa tccggacagc agctcgattt cgctgagctc ttctcttact gcgaccggtc
    11461 gatgccgcac ttcatggtgc cccgctatta ccgggtcctc gaccagctac ctgccacccc
    11521 gaccggcaaa gtgcgcaaga ccgaactgcg cagtcagggg cggaccggcg catgggacgc
    11581 gcagctcgcc gggctcacac cgacccgcca tgcctgaagg aaccaccatg gtcgacgaag
    11641 tacacattcg tgagatcgcg ccacgcctga cgttccagaa ccatctcgtc ccgaccgagg
    11701 tcaaaatcga actggtgcga cgactcatcg acgccggggt ccgggcattc gagctgtctt
    11761 ccttcgtgcg gccggacctg atcccgggac tcgccgatgc cgaagacgtg ttctcgggca
    11821 tccctcgtgt gcccgggctg cgcctaggct gctgtgttgg caatactcac ggactcgtgc
    11881 gggctatcga cgccggcgcg gatgccgcgt cgttcctgct gtcggccgac gaggacttcg
    11941 ccctcgccaa caccggacgc tccacgacag aatccctgag cgaactcgaa cgcatggcgg
    12001 cctacgccgc cgactacgac atcgtgctcg ccacgtacgt gattttcgcc tggggcggcc
    12061 ccaccggccc cgccagggac ggagcacagc ttgaaccact ggcgcgccgg ttgctcgata
    12121 tcggcgtgga tcattggatc ctcgccgact cgtccggata cgcggccccg ccgcaggtgc
    12181 gcgagctcgt gaccaccgca ctcgcccatg tacccgccga aaatctcacc gtgcagatac
    12241 acgacacgcg cggcatgggc ctggccgcct tgccgtccct gctcgagctt ggtattcgca
    12301 acatcgatac cgcgctcgca ggcagcggtg gacaccccgc catgccaggt actccggggg
    12361 gcggaatttg caccgaagac gccatccagt tcctcgaact gtgtggcgta ccgaccggca
    12421 tccacctgcc ccggctcgtc gacacggcca actggttcgc cgagcaaatc ggcataccca
    12481 acaaaggttt cgtacggcac accggcccgg taccacgtga gaacggggcc acgaagccac
    12541 tgacattcac ctggtgacaa agctaccgaa ccaaggagaa agccatgccg aaagttgtcg
    12601 tcgccggcgc gggtttggcc gggctcaccg ccgcgatctc cgctcgtgaa gccggtgcga
    12661 acgtggtact gctggagaaa ggcgaccgca ccgacgtcgg cggcaacgcc gcgttctccg
    12721 gaggattatt cctattctgc tacgacggac cggccgatct gacctcgatc acccaggact
    12781 acgaagccgg catgtgggcc gaccggatcg aggcgccgcc gtacaccact gaggcctaca
    12841 cggacgagtt gatggcgatg agcaacggcc gcgccgaccc gcaactcgtc agagcactca
    12901 cgaacaggtc gctcgacacc gtgcggtggc tcaccgagaa aggcgtgcgc ttcaccttca
    12961 accgcactgt gggtgcccac gttcgtgagg gcatcctgca catcccgcct gggcagattc
    13021 tgaccagcac cggcaacggc atgtcgcgcg ggttcgaggt gatcaaaccg ttggtgcggc
    13081 gcgccgagca gctcggggtc gagttccgct ggtccacgcc gctcgtcgaa gtgcttcgta
    13141 gcaatggacg tgccgttgct gccgcagtcg gcgacgatga acccgtaccg gccgacgcac
    13201 tggtgatcac tagcggtggg tttcaggcaa acaccgaact gcggcgccgt tacctggggc
    13261 cggagtggga gaacgtcaaa ctccgtggca cccgcttggc cacgggtgac gggctcacgg
    13321 cggcgctgcg tgccggcgcg ggtgaggctg gaacgtgggc aagctgccac tcggcggccg
    13381 tggatccgac aatgccctcg cctgggtgca gcgaggcagc accaccgttc ccactgcacg
    13441 gtttctggct tggcgtgctc gtcaaccggg atggcgagcg gttcgtcgac gaaggccccg
    13501 gcccctgggt gaagaactac tcgaaaatgg gcaaggcgat catgcgccaa ccgggttgcg
    13561 aggcgtacga gatcttcgac caacgcaccg cgaaacgcgt ggccgacgag ttcgccgggg
    13621 acgcggtccc gatcgtggcg gccaccgtgc ccgaactcgc cgagcgcatc ggcaccccag
    13681 ctgacgcgct cgtccgaacg atcaaggagt tcaatcgcgc ctgccaagac agccggaccg
    13741 cgaaaggcat cacgcccccc aaatcgcagg acgccactcc actggaccac ccgccgtttg
    13801 tcgcctacca tgccgtcgcc gggttgacgt ttaccttcgg cggggtacgg atagacccga
    13861 acggacgggc cctcgatccc gacggcgtcc ccgtacccgg tctgtacgcg gcgggtgagg
    13921 ccaccggggg cctgttctat ggggactacc ccggcggtgc cgcccttatg cgcgccgcgg
    13981 tattcggccg cgcagcgggc cgcaccgccg cgatcgaggg ttccgattca gccggactgg
    14041 agagtttcta gcaggcgcga caacgggatc cggtcgagac cagcaatgca gtccaagatc
    14101 gcctggctgc cggcgcggcc gtaaacggga tcaactgcca aatgaaaccg ccggacgatc
    14161 tgcacggcgg tcatcgaggg aaaggcatcc tgctcggcaa ccagcgtgga cccgttgtcg
    14221 agtagcacct cgacatggga tccattccgc tgtgggaatt ccttggtaag gtgcggatcc
    14281 accgtcagcc gcgaccgggc ggccaactgt ttcgtcccga ggtcatcgag gttcttccag
    14341 ttctggtcga agataccgcc agtcacgagt acggaagcaa cgctgaactg cacactcaac
    14401 tgcgcggcga cgacatcggt gaccgggccg ctgttgttgc accccggata ccgcaccgcc
    14461 tgctctggga gtcggatgcc gactgcttcg atgcgcttcc agtccggatg gtgccgtcgc
    14521 acgatctcct cggccaactg gcacggcccc tggacgtaga tgcacgccgg ggcgggcttg
    14581 tgcacgatgt cgcgaatcgc gtaaccgctg cccagccctt cgatgagccg ggacgaccgg
    14641 tgccgcgcac cgaagcccgc gagcaatccc gcctcgccct ccagggcacc gcgggccgcg
    14701 gtcaatttgt ggcgtgccag caaggccgcc tccacacccg cccgcgcagc catcgccgaa
    14761 tgcagcacat gctcctgcgt accggcgcgc gcccattcgt tgagcccgca cgcggcactc
    14821 gccgccatgc cgagcgcgcc ctgagtgccg tggcgatcga gcgccaagag gtgcgcacat
    14881 gccgcggccg ccgcgaccgg tcccgtcaga ccggtcggcc ggaacgtcgc agccaccccc
    14941 ggcgtgatca gtgcggaacc gagacggcac attacttcat agccgaccac caccgcggac
    15001 aacaaccggc cggcaggcac atcctcctgc tccgccaacg ccagtagtgc gggaaaaagc
    15061 accatgccag gatgcgagga gctctcgacg tgcgtgtcag tgcgagcagt cgccgccgcc
    15121 gacacactgg tgagataagc cgcagtcgga gcggtggcac gtgtggccgc acccagcacc
    15181 tgcgcggcac cctcatcccc accggataca cccagtgcct tcacggctga gcgcgcttct
    15241 tccgaagaaa cgagcgccgc ggacaaaaag tccgccagac acaacttggc cttgacgatg
    15301 acgtcccctg gcatccgttg cgttgccacg ctcacacaaa agcccgccaa ctcacccgtg
    15361 atgtcaccgc acatgcctgt agtataagca tactgctgat aagttagcta acttacttat
    15421 ggagtgttgc cgtgctgtac gaactcacca acctcgcact gaagctgtac accgtgccga
    15481 aagcgctatc cacgctggag gactacacca ccggcgtcgc ggcgcgtggc agattattgg
    15541 gctgctggga aatagagcat ggcatcatcg tcggccgggt aatcctcctt cgcgagttcc
    15601 aggacgccgt acaactcact gaggagcgag agcagattct cgccagctcc aatcccttcg
    15661 ggatcggtga gtacttggag tcgttcaccg tcgagagcta tgcgcagttc cctttcctgc
    15721 cgcctgtccg caccggaagg tgcggcaacg tctacgagat tcgcacctat aggttgaaag
    15781 taggtggact tctcccgacg atgtccggct gggaagccgc gttacccgaa cgcaccaagc
    15841 ttttccctct gaccacggcg atgtacggcc tggacggcgc acctcgaatc acgcacatct
    15901 ggcctttccc cagcctcgac gaacgtttga ccattcgccg caactcctac gaacgcggta
    15961 tctggccccc gaaaaacggc ccggagaaca tcactcatgc gacttccacc atcgcccttc
    16021 ccaccgcctt ctcaccgtta cattgagctg cacaccacct cgaaccggcg cttcagacgc
    16081 cgtgatgatc catcagtcga atacgctgcc ggacacactc gttccaacat cgcgagaagg
    16141 ttcaaccgag gtggggacat gcctgaggtc ggcggcatcg ggattcagct tgtcaatgga
    16201 ctgccgtgtc aatccatcgg cttgccgcgc gataccactc ctgggcgttg cgttcgaggt
    16261 tgatgcagtg cccggcattc gggagtacat acccctgcaa ctgggcgccg ggtccgtagt
    16321 acggggcctc gtgtcggcgt atggcctgtc cgctggaaca gtcccgtccc cctagtccgg
    16381 cacagaaaaa tttgtccttc ccaccctcga cgacgagtgt cggaacattg atatgacgtg
    16441 tcagaccgtc gagctgatgg accgggaagg ccatttcggg taatggcaag gtcgctttcg
    16501 tttgttcatc gactacgggc acttccggat cggtgtcagc aggattgtaa aacagccccg
    16561 ccctcgtacc gggtcgggtc gtaatatatg tcggatccaa aacgtagcgg aattttggat
    16621 ctagcatcgc cggttgtaca gatgtcccca atccgacgat agcacgtagt gtgatcggga
    16681 ggagagggtt cgggtgcatc atgccggtta cgatgagccc gtcgatgtct cggtatgtcg
    16741 ctgcttccac ccacgccacc gctgatccga ccgaatggcc ctcgagaaca actttcctga
    16801 agcttctgtc tccgatggct ccgccacgca ggtcacgaat gagctggtgc actgtccgag
    16861 ctacagcaga cagtgtcacc gatgcaccga gaggaagcga actacgcccc gatccgatcg
    16921 ggtcgatagt gaaagtcgct ttgccgctct cggccatagc acgaacatac gaatagcgtt
    16981 ctgggcgata ggggaagtcc caataactgt ggtcataagc accaccggga accaacaact
    17041 gaacggtgcg cgtttgccca ctggacggaa ggcagagtcg gccatgaact tgaaaatgtg
    17101 ccggtccatg tgcaacaagt cgaactggcg tgattgtgtt catacaacgg ataccttggc
    17161 catcagcggc ataagcaggt gccgattccg aggtgccgaa aatcgcggcg gtgatgagca
    17221 ctgcgagcac agtcaagaag cgcgggcttc gtatattacg cgggagcata gtcgcccttc
    17281 cgccgatcgt ggcacgctcg atggggcgaa ttgttgaacg tcgatacaac agaactccgg
    17341 tggagctgat caacctgagg agtcgcttgg ccgcggacgc cccgcgtcgc gtggatgagc
    17401 ggagacaagc tctcaggcac tttgccgacg acatgaccac ccacagggca gcacctcccg
    17461 gttcgcgtta ttccctcggt gcacgacgaa gcaagatctc acttacccgc tccaaaaccg
    17521 aatacacgcc ttctcgtcaa tacaagcatg ctgatactag atacggaagc tgtctctgtc
    17581 aacggccgcg ccttccggtt gctacggcca gccgcaaaat aggcagacca gtggtcctcg
    17641 tcgcatgctg cggcgatgcc tatcggcacg aggcttgtcg ccgatgtgcg gccggttcgc
    17701 gtggcacgtg tggacgctgc ggtccccgcg gcgctgcggt gttcggtaca gcggggcggc
    17761 tattgttccg gttcgcttgc cagcagggcg cgggagatcg cggcggcggt tgccgtgatg
    17821 tcggcggcga gtttctcggc gacggctctg gtcagccgga acgatggcgc gcccatggcg
    17881 acggcggcga cgagcgtcct tcctgccccg aaaacgggcg cggccagtga gttcagtccc
    17941 ggttcccgtt cctcctcggt gaaggcccag ccctgtttgc ggacctggtc gagcagcttc
    18001 tccagcacct gcggatcggt gatgctgtat tcggtgtagc cgggtagccc ttcttcgagc
    18061 gccgcctggt gggcctgttc gtcgtaggcc atcagcactt tccccgccgc ccctgcctgg
    18121 agcggcagga tctggccgat gtagccgcgg tagatgatgg agtgcgtgga ttcggcgccg
    18181 agcacggaga cccggttagt gccctggcgg acgtagatgc cacaggattc ccggctgcgg
    18241 tcgcgtagcg cggtgatgtg cggtccggcg gcggcgagca gatcggaacc ggctttcgct
    18301 gccgcggacc acgcggtgac acgcaggccg atgctgtact cctggcgctg gcgctggagc
    18361 aggttctcgc cgacgagagt gcgcaggatg cgcgcgacgg tcgaggtcgg catgccagtg
    18421 gcctggacga tgtcggccgc gcgcagcctc ggcgttgtgg cggagaaaca gtcgagtatc
    18481 tgcgccgact tgcgcacgac ctgcaccgaa ccgccgtcgg tccgttcccg atcggttggc
    18541 accctgacga cctcgcttcc cgcagtgcgg caagagctgc cgctggccgg tcaaattcgc
    18601 atgcctttgt gccgtctgtc aagtccttga cagacgatgc tggttgccga agagtgaacc
    18661 gcattgtggc aatgatattc acgatgcagc attacggagg agtggttttc gtgtcggaga
    18721 tccgttcccg gttgcgggaa ctgcttgccg agcggtcggc ggtcgtggca cctggcgtgt
    18781 tcgacgggct gtccgcggca ttgaccgtga gcgcggggtt ccgcgccgcc tacctgtcgg
    18841 gcgcggcggt cgcggccgcg aacggcctgc cggacgtcgg ccttgccacg cagacggagt
    18901 tcgtgcagct gctggcgctg gtctcgggca ggatggacgt cccggtcatc gcggacgcgg
    18961 ataccggctt cggcgatgtc acacacgcct accgcacggt ccagctctac gagcgggcgg
    19021 gcgctgcggc gatccagctt gaggaccagg agttcccgaa gcgctgcggc cacatcgacg
    19081 gcaagcgggt cgtggacgcc gaggagtttg cccgcaagat cgaagccgcc gcgcaggccc
    19141 ggcgcgatcc ggaaacagtg ctgatcgggc gcaccgatgc ctgtgccgtg cacggtttcg
    19201 acgaggcggt gcggaggggc aatctgtacg ccgaggccgg ggctgatctg gtgttcctcg
    19261 aggcgccggg cacgttcgac caggtgcggc gggtgccggc cgaggtgacg gcgccagcgc
    19321 tgttcaacct ggtaccgcgc ggcaagacgc cgcaggtcga attggccgag ctcgccgagc
    19381 tcggctacgc actggtgatc atgcccggcc tgtgcgtggg cagcgcagct gccgccatgc
    19441 gcgcggcgct ggaacgggcg gcgcgcgggg acgtgggtac ggacgggcag gattcgccac
    19501 gcggcctgtt cgacgcgctc ggcctgtcgt tctgggagga cctgcgggag agctacgcgg
    19561 ggcaggccgc cgatgcctga aacgctgatc cagaaggtac tcggccgggc atcgggcggg
    19621 caggcggagg tcggggagat cgttgtctgc gaggtggacc tgaccgcgct gatcgacatc
    19681 cagttcgccc atgaccggct ggccgatgtg gtcagcgtcg cggatccgga ccggatcatg
    19741 atcgtgttcg atcacgctgt ccctgcgcct tcgatacgcg atgcggaatc cggccgcaaa
    19801 gcgcgagcct tcgccgccga gcacggcatc cggaagctgt tcgacctcgg acagcacggc
    19861 atcgtccacc aggtactcgc cgagcaaggg ctcgccaggc cgggctgggt ggtcgcctgc
    19921 accgattcgc atacctgcgc ggcgggcgct gtcggtgcgg cggcacgcgg gctcggtccc
    19981 gccgaggtgc tccagatcgt gtgcaccggg cgcacctggc accaggttcc cccgaccgtc
    20041 cactatgcac tcagcgggcg gaaaagcccg tgggtcaacg gaaaagacat cttcctgcac
    20101 atcgcgggtc ggtacggcga cgcaacaggg cacgcggtcg agttcggcgg tcctggcctt
    20161 gccgagctgc cgatggccga ccggcggacg atcgcgaccc agggggccga gatcggcgcc
    20221 gacttcacca ttttccctgc cgatcagcat tgcctggact atgtcaccgc ggcggcgccg
    20281 gatgccgaac cggcaccggt gcgaccggac gaggacgccg aatacgctgc ggtgcgcggg
    20341 atcgagctaa gtggcatctc gccgatggtc gccaggccgg gcaccgtgat cgagaacgcc
    20401 ggaccggtcg gcgacctcgt cggcaccagg atagaccagg cgttcatcgg ttcctgtgcg
    20461 aacggacagc tcgccgatct cgaggtcgcc gcggaaatcc tgaaaggcca acaggtcgcc
    20521 agcggaaccc ggctgatcgt caccccggcg agccagcgga tctacctcga ggcgtccagg
    20581 cgcggcctgc tcgccgatct ggtcgaggca ggggcgacgg tcaccaaccc gacctgcggg
    20641 gcctgcttcg gctaccacat gggcaccctg gccgccggcg aggtgtgcat caccgcgagt
    20701 acccggaact tcaagggacg catgggaagc acggaggccg aagtgtacat ggcctcaccg
    20761 gcgaccgtgg ccgcttctgc gatcagggga gtcatcagcg atgttcggga ggtggtcggg
    20821 tgaaccaggt cagcggcagg gcgtgggtgt tcggtgacgg tatcaacacc gacgacatgt
    20881 acccgggttt cgcgatgcgg ctgccgatcg aggaggccgc gcgacacatg ttccacgcga
    20941 gcaggccgga atggccgcag ctcgtgcatc cgggcgatgt cgtcgtcgcc ggacgcaatt
    21001 tcgggctcgg ctcgagcaga ccggttccct tgctgttccg ggaactcggg gtcgccgcac
    21061 tggtcgcgga gcagttcaac agcctgtttt tccgcaactg catcaactac ggccttcctg
    21121 ctgcgacgct gccatcggcg accaggctga tccgcgaggg cgagacggtg ctgatcgact
    21181 tcaccgacgg cagcctgcgc gtcggcgaaa cggtccaccc gatcgcgccg ctgcctgagc
    21241 tgctgcgtgc ggtgctcgac gcggaaggac tgctccggca actcgaactg gacggcaaac
    21301 tccggccggg gaaaggataa cgatgtcaga ccaggaaacg gtccgatgtg tgctcatgcg
    21361 aggcggtacg agcaagggcg tgtatttcca cgaatccgat ctacccaaac caggaccgcg
    21421 gagggaccga ctgctcaagc ggctgatggg cacccctgac gtactgcaga tcgacgggct
    21481 cggcggttcc cgtccgatca catcgaaggt ggcgatcatc gcaccgtccg caagggacga
    21541 cgccgacgtc gactacacct tcgcgcaggt ctcgatcgac gaggacgaga tcaattatac
    21601 cggcaactgc ggcaacatct cctccggggt agggccgttc gcgatcgacg agggaatcgt
    21661 tccggccgtc gacgagatca ccgaagtgcg gatccacaac accaacaccg ggaaaatact
    21721 cgtggcacac gtgccagtcg gcgacggtaa gtccaaagtg gatggtgact tcgcgctgcc
    21781 gggagtgccg ggtaccggcg cggaaatcgt gatggactgg agcggtacgg tcggagcaaa
    21841 gaccggcaaa ctgctgccga ccggttgccc ggtcgatgac atcgaactgt ccgacgggac
    21901 gtgcgttgcc gctaccatct gcgatgcggg taaccctgcg gtctgggcgc acgccgaaga
    21961 cttcgggctc accggcagcg aactcagcgc ggagatcaac gagaacaccg cgctgatcga
    22021 ccgagtgcgc gaactgcgcg gccgggccgc cgtgctcgct ggtctctgca ccgactggcg
    22081 tgcggtggac acgcagtcac ctggcatccc gcttgccggg ctggtcgccc ctccggcggg
    22141 ttacacgacg ctcaatggcg ccgatatcgc cgcgcgagac atggatctgc gggtccgctt
    22201 gctgttcatg aaccggctgc acgaaagcat cgccggtacc gcatcgatct gtctcaccgc
    22261 cgcgtcgagg gtgccagggt cggtgccggg aaaggtcggc gccaaccgca cggatggctt
    22321 gctgcttgcc ggccacccct cgggtgtcac cccggtgcgg gtcgagggct cgtccgtcca
    22381 cttcggactg ctcgggttca gccgaacggc gcggcgcctg atggacgcca ccgcctacta
    22441 tccgcgttcc accttctgag ccaacgggag tacgcatggc aatgttgccg atgcgcagtg
    22501 actcagcgga aatcgccgcg aatctggatc ggttaccggt cggcccatgg catcggc
//
