LOCUS       NZ_KB905411            10816 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Sciscionella marina DSM 45152 A37UDRAFT_scaffold_37.38, whole genome
            shotgun sequence.
ACCESSION   NZ_KB905411
VERSION     NZ_KB905411.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Sciscionella marina DSM 45152
  ORGANISM  Sciscionella marina DSM 45152
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Sciscionella.
REFERENCE   1  (bases 1 to 35302)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Sciscionella marina DSM 45152
            collection_date                   :: SEP 2006
            lat_lon                           :: Missing
            depth                             :: 516 m
            alt_elev                          :: Missing
            country                           :: China
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 45152
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: 19196758
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Sand; Sediment; Marine; Aquatic
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11892
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site :: Marine sand sediment at a depth of about 500 m,
            the northern South China Sea
            Cell Shape                        :: Rod-shaped
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28 C
            pH                                :: 7
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000379465.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 01:37:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,209
            CDSs (total)                      :: 8,146
            Genes (coding)                    :: 7,961
            CDSs (with protein)               :: 7,961
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 1 of 185
            Pseudo Genes (frameshifted)       :: 52 of 185
            Pseudo Genes (incomplete)         :: 155 of 185
            Pseudo Genes (internal stop)      :: 15 of 185
            Pseudo Genes (multiple problems)  :: 34 of 185
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:59:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 23600
            Orig. end                         :: 34416
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905411.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405877
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5816](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5816)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(420..435)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.03"
                     /tool="antismash"
     gene            complement(1708..2172)
                     /locus_tag="A37U_RS0129370"
     CDS             complement(1708..2172)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0129370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020500250.1"
                     /transl_table=11
                     /translation="MPEELRVEDLGEGEFAIVRYGRAVSHWYASASVFEQVGSRYSSRR
                     VVECAVAYLTEHGAGGQLPESVDLERLTTTDENFLAQVRRRLEEPVRLPEDPRNRPTET
                     VDALEERITEQTGAIDRGDENRLPGTSTEDSEPEGADPGARLHTVQEPPV"
     gene            2261..2434
                     /locus_tag="A37U_RS45930"
     CDS             2261..2434
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335571.1"
                     /locus_tag="A37U_RS45930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CsbD family protein"
                     /protein_id="WP_020500251.1"
                     /transl_table=11
                     /translation="MDDETTNKAEELQGKAKEKAGEVTDNEQWQMEGKAQKTKGSLKQA
                     GDKLRKALKPKR"
     gene            complement(2664..2945)
                     /locus_tag="A37U_RS0129380"
     CDS             complement(2664..2945)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0129380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020500252.1"
                     /transl_table=11
                     /translation="MTEQLDVKRLNGDSCAVTIRRGMATTHHRVTMSGELFDDLLLPGA
                     AATRVVEQTMRYLLERRSAGSIPHDIDLDELREHDARYLNALRKRLAG"
     misc_feature    complement(2685..2687)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3073..3339)
                     /locus_tag="A37U_RS45935"
     CDS             complement(3073..3339)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015734.4"
                     /locus_tag="A37U_RS45935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PASTA domain-containing protein"
                     /protein_id="WP_020500253.1"
                     /transl_table=11
                     /translation="MSHDDRVEVPDVTGLGAVEACGAVRAAGLSPRGPQHAPEPIDGTI
                     IQQDPAPGVSVNIGNDVTLWSDNGRAAQEVLDPDLSTATAPMT"
     gene            complement(3423..4061)
                     /locus_tag="A37U_RS45940"
     CDS             complement(3423..4061)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020500081.1"
                     /locus_tag="A37U_RS45940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ANTAR domain-containing protein"
                     /protein_id="WP_020500254.1"
                     /transl_table=11
                     /translation="MTTGKLWGPSILAALGEGPLATADIWCDERWPHLRFERLRDRVEA
                     TQLDVIARVRGAAAMPSIWDEDGIMVLSVYLDGPANERTVATLARHEPLVTSAVTMAGI
                     AERNQQQSQRVLDALASRAAIEQAKGVIMGIRNCDPNAAWDVLRAVSQEVNLKLRELAT
                     ALVEHIGQVPADKPVNQSVVHVDERAREIAAQLWKGLRQEQIGDGTHVP"
     misc_feature    complement(4025..4044)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.06"
                     /tool="antismash"
     misc_feature    4415..4429
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 20.76"
                     /tool="antismash"
     gene            complement(4532..4843)
                     /locus_tag="A37U_RS0129395"
     CDS             complement(4532..4843)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039733.3"
                     /locus_tag="A37U_RS0129395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6338 family protein"
                     /protein_id="WP_020500255.1"
                     /transl_table=11
                     /translation="MPTKARNPGSNAGAHRVGLELDDGSCLVGQLLTFNPDPPHTGGRE
                     LVLTAPLSYRGPGAAVTTPLESLVACVAAARVVAMTAGSELAADGAAHPHATVTVPPG"
     gene            complement(5001..5816)
                     /locus_tag="A37U_RS0129400"
     CDS             complement(5001..5816)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228354.1"
                     /locus_tag="A37U_RS0129400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_020500256.1"
                     /sec_met_domain="Linocin_M18 (E-value: 9.5e-72, bitscore:
                     232.5, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHLLRELAPIPQAAWDKLEEEAKDQFTVHLAGRRLVDWSGPHGW
                     EHSATGLGRKRVLEPEHQNRGDIELHRRKVLELAEVRLPFAVNRSELDDAERGAGDLDL
                     DALDAAALHLARLENHAVFHGWREAGFTGMTAASPHRPVPLGSDPQNYPKSTALAVNTL
                     RDAGVPGPYALAVGPRDHMDILAAAEQGGYPVLDHLRRILGGGKVVRAPGIEVAVVLGL
                     GAGNFLFDVGQDISIGYEGHDRDFVRFYFEENFCIRVVERSAAVALARE"
     gene            complement(5813..6370)
                     /locus_tag="A37U_RS0129405"
     CDS             complement(5813..6370)
                     /GO_function="GO:0043169 - cation binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009080022.1"
                     /locus_tag="A37U_RS0129405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemerythrin domain-containing protein"
                     /protein_id="WP_020500257.1"
                     /transl_table=11
                     /translation="MPDITELILDDHQEFRRRFAALDEVDTPEELAKIWRPLSALLDLH
                     AVAEERIFYPELVHRGSDAEDETVDAVDDHNQIRDAVHEADSYPVGSAPWSSAVRRARL
                     ENSEHMAEEEDGALADFRRHADPGLRADLGARFAAFKQEHPAAAGLDTSDIAPNRYLAS
                     VEAEGAGDGSLGLGPLDGRRNG"
     gene            complement(6419..6886)
                     /locus_tag="A37U_RS45945"
     CDS             complement(6419..6886)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021536.4"
                     /locus_tag="A37U_RS45945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2267 domain-containing protein"
                     /protein_id="WP_083933979.1"
                     /transl_table=11
                     /translation="MSSTRVSLPADRGMPAAEYIQYGRRGFPVRYDEIVDRVRAGGGPV
                     NKVEAEALVQSVAAVLGQRLTGAQAGRLADHLPEELRRSLIEADQGQRFGAVEFLGRVA
                     QREAMGRTGEQLRVHVRAVFGVLAEAVSTGEFEEVLDQLPADYEQLVSVAG"
     gene            complement(7065..7538)
                     /locus_tag="A37U_RS45950"
     CDS             complement(7065..7538)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020501479.1"
                     /locus_tag="A37U_RS45950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_063712847.1"
                     /transl_table=11
                     /translation="MPGGTEFASERRPPVQYVAFATGLVLLLIGILGFVPGATTEYHLL
                     QLVGHGPSALLFDTFSVTVARNFLFVAFGIALIAVSRTSKLAHGLLITVGLIYLLLYCY
                     GLLAGHGADANLLALNDPDNWLHLAIAVVLLAMALLAGQNRHPQRSTSPPGDV"
     gene            complement(7998..8300)
                     /locus_tag="A37U_RS54000"
     CDS             complement(7998..8300)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016564.4"
                     /locus_tag="A37U_RS54000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SsgA family sporulation/cell division regulator"
                     /protein_id="WP_240437710.1"
                     /transl_table=11
                     /translation="MRLSFHVRRNERTVWTVARTLLATGLHTPSGEGEVRVRPVDGESA
                     VAVELYSPSGQAEFVTDAGQLGEFVDATYRFVSSIQAQAIVDAEFDSRRWLDSGE"
     gene            8230..8451
                     /locus_tag="A37U_RS54005"
     CDS             8230..8451
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS54005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_240437711.1"
                     /transl_table=11
                     /translation="MASNVLATVHTVLSFLLTWKESRTAHGSPLVYWNSTSTGIAVPSD
                     NSMSKIAVSVIEELSITTRSRLSLLVSP"
     misc_feature    complement(8810..8824)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            9270..9695
                     /locus_tag="A37U_RS45960"
     CDS             9270..9695
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS45960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020500261.1"
                     /transl_table=11
                     /translation="MISDQPAEKPSVADDGVVEVHTSIDSAQLAVLRNVAATLTMDAGF
                     TVDSVEDARLLVDEVCSTLIRNAERGAQLSCRFRADDRFYLHAQATASPDAVVDRSSWS
                     WRIMSTLADTLISWTNANPGQPTTLHIEATKASDGCP"
     gene            9692..10495
                     /locus_tag="A37U_RS0129430"
     CDS             9692..10495
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020660130.1"
                     /locus_tag="A37U_RS0129430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SigB/SigF/SigG family RNA polymerase sigma
                     factor"
                     /protein_id="WP_020500262.1"
                     /transl_table=11
                     /translation="MTEGPDHLGLSKQAEHQEYAQFAEDFHEFAALSPENPRYERLREK
                     LVREHMPLAEHIAMRFRHRGVQLEDLRQVAMLGLINAVDRFEPDRGNDFLAFAVPTIMG
                     EVRRYFRDAGWAMRVPRRLQELHLNLGKAIDELSQRTGRAPRADELAEYLGIELGEVRR
                     GLEAGSAYRADSLNSPVGGTTESDSQAVSDTIGEQDTNIEDVELRETLQPLLADLPERE
                     RRILTLRFFGNLTQSEIARKIGLSQMHVSRLLAQSLKQLRERIYG"
     misc_feature    complement(10582..10596)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
ORIGIN
        1 ctcgcgtaat accgcggcga gatcatcgag tacccaccag ttgcccagca gcgaggacgt
       61 cgtcgcccat tgcaaggcgt ccacttcgat cacccgcctc cgccgcaccg cacccaactg
      121 ccgccacaac ggcctgtcgt acaaccagcg aggatcaaca gtggggccga cagccacgaa
      181 caccagatcg gcatcgtgct ctggcaagtg ctccagagat acgggcacga atgatctcgc
      241 gctcgaggcc gccttggcct gggccgcggg gcgtcgaaga tcgagagcgg ccactgtcga
      301 ggctgccggg gtagcgccgc ccacggtgaa gatcgagtcg gctgccagtc ccggtgagat
      361 gatcgagatc gtcggcgcgg atcgcgaccg cagcgcgctt tgcagctgct gcctcgaggc
      421 cgacaacatc gtcaatgcat gccgagttcg cctcagccgt ccgagtgcgg ctccgacggc
      481 cagggagtcc gccgctagcc gccccgttcg ggcaacccgt tgcacactgc ttgatatccg
      541 gtccaggacg acggcctgct cgacgggacc gccgctgagt ccgatgaccc tggtcggact
      601 cagtgccacg agcttctcga gctcgagctg cccacctggc gatgacacat cgaccacagg
      661 cccctcttgc agcatcgcga tcgcctcaac gatcggatct ttggcaagaa acgacgctgt
      721 cgcctgctga tggcggccca gcatgagtgc cagacccgcc gtagctccgt ccaaggtcgc
      781 caaccgctca accggaactt gtgctgcctg cttccgcgtg acagaagcac agcctccgat
      841 gaacccgccg ataccagcgg tgagtaccag tcgacggccg atcaccgggg aactcttcga
      901 acggatagct cgtgcggcat cgacgatctc cctcactccc ggtcagcgcc tgcccagtga
      961 gtcggagaat gagcatcgaa agttccggtt cgacagtgtc gcaatgctcg acgacccgca
     1021 gtcggtccgt ctcccgaacc ggcgtcccgg cttcagtgca ccagcgggag atcctggcaa
     1081 gccatctgct gggcaggcca tggccgcttc gcgatcgagt cggcgtcgag ggctgggcac
     1141 ggcagcgcat aaaagcccat gggtgtgatg gcgtcaacgc ggagggcgcc gcgggacgac
     1201 cggtgtccgg cctcgcgcta cgcgggggcg gaattctctg ctggcacaaa ccgataggcc
     1261 tgggcgtggt gagcgctcag agctgtcgca caggcacgac atgcgagctt gcgggtctcg
     1321 atgaaagttt cttcggccga ggagaaaccc gatggatgct taatcgtatt cacaccaaca
     1381 tgcgcgcagt ctcggcatac ccccgctcca cacgtcgtgc agatcgccat ggcggatgtg
     1441 gactcaccat gttcggcgca gtcgaaacag ttcatgattt cctcccttct caagggcgct
     1501 tgttcgatat agtcatcagc ggatcggcgt gtctccagag ccctgtggac gtgtgcgggg
     1561 cgttcatgaa gaggtcctgt gcgttcgtca gccgcttgat gcgcgttctc cgactgtcgt
     1621 ggaccaaacc gctcggtatc ggcccccggc tcgttccggc accgcgcgtc gatggcatcg
     1681 gcgcggatac gcggcatcga ccaacggtca gaccggcggt tcctgaacgg tgtgcaggcg
     1741 tgcaccggga tctgcgcctt ccggctcact gtcctcggtg gacgtgcctg gcagtcgatt
     1801 ctcatcgccg cggtcgatgg ccccggtctg ttcggtaatt cgttcttcga gggcatcgac
     1861 ggtctccgtg ggccgattcc gcgggtcttc cgggagccgg accggttcct cgagtcgtcg
     1921 acgtacctgc gccagaaaat tctcgtcagt tgtcgtgagc cgctcgagat cgacgctctc
     1981 cggcaattgc ccaccggccc cgtgttcggt cagatacgcc acggcgcact cgacaactcg
     2041 tcgtgagctg taccgcgagc ccacctgctc gaacacggaa gcactcgcat accagtgcga
     2101 cacggcacgt ccataccgga cgatcgcgaa ctcaccttct cccaggtcct cgacgcgcag
     2161 ttcttccggc atgggcacct ccttccgcct ttggcgtacc cacgcctcgg cgatcgaaac
     2221 acgcaagcat agaacgacta cctgtgggta ctccctgtct atggatgacg agacaacgaa
     2281 caaggcagag gaattgcagg gcaaggccaa ggaaaaagca ggtgaagtga ccgacaacga
     2341 gcaatggcag atggagggca aagcacagaa gacgaagggc agcctcaaac aggcgggtga
     2401 caaattgcgg aaggcgttga agcccaagcg ttagcggtgt tctcagtctt cctgctgtgc
     2461 gcctcggtcc gttcggccga gttccggcgg agtccttgcc gcaggtacgg acgaggccgg
     2521 gctcggcctc tgttcacgac cgccgtgagc tcccgcttcg gtcccctgct ctccgatatc
     2581 tcgtggttcg acgtcccaca atccttgatg cgcagacaac gacacacgcg gtcacacgga
     2641 agggaaagcc cccgggcagg acctcaaccg gccagtcgtt tccgtaacgc gttcagatag
     2701 cgggcgtcgt gttcgcgcag ctcgtccaga tcgatgtcgt gcgggataga gccggccgag
     2761 cggcgttcca gcaggtatcg catcgtctgt tcgacgacac gtgtcgccgc ggctccggga
     2821 aggagaaggt catcgaacaa ttccccgctc atggtcacac gatggtgcgt ggtggccatc
     2881 ccacgccgga tcgtgaccgc acacgaatcg ccgttgagcc gcttcacgtc gagctgttcg
     2941 gtcatctcgg gtctcgtccc tccattgcac gtctcggccc gccgtcttcc acgcgtgccg
     3001 atcaccggcc gcggttgtcg tcaggtgatc acatacccgc ggccggcgcg gtgcaaacgc
     3061 ctcagcggtc ggctaggtca tcggtgccgt ggcagtggag agatccgggt cgaggacttc
     3121 ctgcgcggct cgaccgttat ccgaccacag cgtcacgtca ttcccgatat tgaccgagac
     3181 tccgggcgcg ggatcctgct gaatgatggt gccgtcgatc ggctcgggag catgctgcgg
     3241 tccgcgaggc gacaagccgg cagcccggac cgcgccacac gcctcgacag cgcccaaacc
     3301 cgtgacgtcg gggacctcga ctctgtcatc gtgggacata tgacgacggt agatgatcca
     3361 tttcggttcg gaaacccgta cgcagcaatc gggtccggga cctcgccgtc ataccgtacc
     3421 ggtcacggca cgtgtgtccc gtctccgatc tgctcctggc gaagcccttt ccacagttga
     3481 gcggcaatct cccgggcgcg ctcgtccaca tggaccacgc tctggttcac gggtttgtca
     3541 gccggtacct gtccgatgtg ttccaccaag gcggttgcca gttcacggag tttgaggttc
     3601 acctcctggc tcaccgcgcg gagaacatcc caggcggcat tgggatcgca gtttcgtatc
     3661 cccatgatga cgcccttcgc ctgttcgatg gccgcccgcg aggcgagcgc gtccagaaca
     3721 cgctgtgact gctgctgatt gcgctcggcg attccggcca tcgtgaccgc gctggtcacc
     3781 aacggctcgt ggcgggcgag cgtggcgacg gttctctcgt tcgcgggacc atcgaggtag
     3841 accgacaaga ccataatccc gtcctcgtcc cagatcgagg gcatcgcggc ggcgccccga
     3901 acccgggcga tgacgtcaag ctgggtggcc tccaccctgt cccgcagccg ttcgaatctc
     3961 agatgcggcc agcgttcgtc gcaccagatg tcggccgtcg cgagcggccc ctcccccaac
     4021 gcggccagga tcgaaggtcc ccacaatttc ccggtcgtca ccggagtcaa cgattctccg
     4081 acaccgctgg ccgcaagtac tctcagtcgc cctccgcctc ggttgcgggc aggatgggca
     4141 acactgacgg cagcgccgag gtcaccggcg acatcgcagc gtaggccggt cagcacgcgg
     4201 gacaacaggg cagccagcga tgtggctaca ggctccaagg gcgtcgaatt catgccattc
     4261 cacagacgat ctcacggacc acatggagct tcgatgaaac cccacagggc cactccgtct
     4321 tcgtggaagc caggtgcccg tgccccgggc gcggcacgaa ttgctcgcac gcgccccagt
     4381 gcggtgtcgc gcccgccctt gaagtgtcga tacgatcaat agcgtcgata agaaaaagca
     4441 taacgaagca gcaacgaatt tgccagcccg ctttcaggtg accagcttgt ctaccgagcc
     4501 tggtttgccg gtaaacaccc gaaaaaatcg gtcatccagg cggaaccgtg accgtggcgt
     4561 gcgggtgtgc ggctccgtcg gccgccagct ccgaaccagc tgtcatggcc accacgcgag
     4621 cagccgccac gcaggccacc aacgactcga gtggcgtcgt caccgccgcg ccgggcccgc
     4681 ggtagctcag tggagcggtc agcacgagct cccggccacc cgtatgcggc gggtcggggt
     4741 tgaacgtcag cagctgcccc acgagacagc tgccgtcatc gagctccagc ccgactcggt
     4801 gcgcaccggc attgctgcct ggatttcgcg ctttcgtcgg cacgccggca ccagtgcgcc
     4861 accatctatg gcgacgcgcc caaccgctgc ccatcagcac cactttcacc tccacgatct
     4921 gcggtcacga cttcctgcga ttcctgtcga gggataaccc gtttcacgac tgccgaaacc
     4981 cgcgcgaacg gtacgagcac ctattccctg gccagcgcca cggcggccga tcgttcgacg
     5041 acccgtatgc agaagttctc ctcgaaatag aatcgcacga agtcccggtc atgtccttcg
     5101 tatccgatgg agatgtcctg tccgacatcg aacaggaagt ttcccgcacc gaggcccagc
     5161 acgaccgcca cctcgatccc cggcgcccgc acgaccttac cgccgcccag gatgcggcgc
     5221 aggtgatcga gaaccggata tcctccttgt tccgccgccg cgagaatatc catgtgatcc
     5281 cgcggcccga ccgccaaggc atacggtccc gggactccgg catcccggag tgtgttcacc
     5341 gcgagagccg tcgatttcgg gtagttctgc ggatcgctgc cgagcgggac gggccgatgc
     5401 ggactggccg ctgtcatgcc ggtgaaaccg gcctcgcgcc acccatggaa caccgcgtgg
     5461 ttctccagcc gggccaaatg cagtgccgcc gcgtccagcg cgtccagatc gagatcaccc
     5521 gcgccacgct cggcgtcatc gagttcggac ctgttgacgg cgaacggaag gcgcacctcg
     5581 gcgagttcga gcacctttcg ccggtgcagc tcgatgtcac cccggttctg gtgctcaggt
     5641 tcgagaacgc gcttacggcc cagtccagtg gccgagtgtt cccaaccatg cgggcccgac
     5701 cagtcgacca gccgccgccc cgccaggtgc accgtgaact ggtccttggc ctcctcctcg
     5761 agtttgtccc atgccgcttg cggtatcggc gcgagctcac gcagcagatg gttcatccgt
     5821 ttcgcctccc atcgagcgga cccagtccga gtgaaccgtc tccggcccct tcggcctcga
     5881 ccgatgcgag gtacctgttc ggggcgatat cgctcgtgtc gagcccggcg gcggctggat
     5941 gctcctgttt gaacgcggcg aaccgagcgc ccagatcggc gcgtaggcca ggatccgcgt
     6001 gtctgcggaa atcggcgagc gcgccgtcct cctcctccgc catgtgttca ctgttctcca
     6061 gccgtgccct gcgaaccgca ctactccacg gtgcgctgcc caccggatag ctatctgcct
     6121 cgtggaccgc gtctctgatc tgattatgat catcgaccgc atcaacggtc tcgtcctcgg
     6181 catcggagcc acggtgtacc agttcgggat agaagatccg ctcctcggcc acggcatgca
     6241 gatccagcag tgccgaaagc ggccgccaaa tcttcgccag ctcctccggc gtgtccacct
     6301 cgtcgagcgc ggcgaagcgc ctgcggaatt cctgatgatc gtcgagtatc agttcggtga
     6361 tatcgggcat gaccaagcac tacccgattt cctcgccggg acacatcccg cgctcgggtc
     6421 acccggcgac actgaccagc tgttcgtagt cggcgggcaa ctgatcgagg acctcctcga
     6481 actcgccggt cgaaacggct tctgcgagaa caccgaatac cgcgcgaaca tgcacccgaa
     6541 gctgctcacc ggtgcggccc atcgcctcgc gctgagccac ccttccgaga aactccacgg
     6601 ctccgaaccg ttgcccttgg tccgcctcga tcagcgaacg gcgcagctct tcgggcagat
     6661 gatcggcaag acgtccggcc tgcgcacctg tcagacgctg gcccagcacc gccgctacgc
     6721 tctgtacgag cgcttcggcc tccaccttgt tcaccggacc accgccagct cgcacccggt
     6781 ccacgatctc gtcataccgc actgggaatc ctcgtcggcc gtactgaatg tattcggctg
     6841 caggcatacc ccgatcagcg gggagcgaaa cgcgggtcga tgacatcaac cacaccgaac
     6901 tccacgtgat atctacgaag gccacttgac cgccgagcca cgagccgcac ccttgccaag
     6961 gctcgcggac cggcgtcgcg gagacgggtc ggcaggtgga ccgcgcagat cccggcgacg
     7021 atgttcttga ttccccggca cgtctcccct tcgctgagct cggctcacac gtccccgggc
     7081 ggcgaggtcg accgctgcgg atggcggttc tgcccggcga gaagcgccat agccaggaga
     7141 acgaccgcga tcgccaggtg caaccagtta tcgggatcgt tgagcgcgag aagattcgca
     7201 tccgcaccgt gcccggcgag cagcccgtag caatagagca gcagataaat caggccgacg
     7261 gtgatcagca ggccatgggc cagtttcgat gtcctggaca cggcgatgag tgcgataccg
     7321 aacgccacga acagaaaatt ccgcgcaacc gtgaccgaga aggtgtcgaa caggagcgcg
     7381 ctcggtccgt gaccgaccag ctggagcagg tgatactcgg tcgtcgcgcc gggtacgaaa
     7441 cccagtatcc cgatcaggag aagcacaaga ccagtagcga acgcgacgta ctgcactggt
     7501 gggcgccgct cggacgcgaa ttctgtcccg ccaggcatct cgcctcctct ggaatatccc
     7561 atcacctgcc gcgaaccgcg acacatgcat tcggctaccc gaaatgccat tcggcgaaac
     7621 cccgcgagag gccgctaccc ggacagtgcg cacgcaccgc cttctgccgg atatgtcgcc
     7681 agcgagaggg acggccacca ggagaagtga gaagtgacca tgaccgggcc ggatcccaca
     7741 acggccaaca cagacctgcc ccgaatcgcg atcgtcaccg gtgccgactc cggcatcacc
     7801 gtcaatgcga tgccccatgg ggcatcgcga caccgatgac cgctccggaa gacaccgagc
     7861 cgcacgagcg gccccgtccc ggctggcgac tacctgatcg agcgccccgg tgtagctttc
     7921 cccgcctggc gtgtcgtctt gtggaaagaa tcgagtctcg ccgaaggaac cgtcggagtt
     7981 cacggtctcc ggcccaccta ttcgccggaa tcgagccacc gacggctgtc gaactcggca
     8041 tcgacgatcg cctgcgcctg tatcgaggac acgaaccggt aagtggcgtc cacgaattcg
     8101 ccgagctgac cggcatcggt gacgaattcc gcctgcccgc tcggcgaata cagctcgacg
     8161 gcgaccgccg attcgccgtc gactgggcgg actcgcacct ccccttctcc cgaaggagtg
     8221 tgcaggccag tggccagcaa tgtcctcgcc accgtccaca cggttctctc gtttctcctg
     8281 acgtggaagg aaagccgcac ggcccacgga tcaccgctgg tgtactggaa ttcgacctcg
     8341 acaggaattg ccgtgccgtc cgacaacagc atgtcgaaga tcgcggtgtc ggtgattgaa
     8401 gaactatcga tcacgactcg ctcccggttg tcgcttctgg tttctccgtg atacccgtgc
     8461 gactgtgata cccgtgcgaa tgtgtgacaa acgcgcgtct ttggggccac cgcatggatc
     8521 aaggaacggc acaccgaccg ggggcggcgg cgcgctgtcc ttgctggttc cgagggccga
     8581 cctctcgtgc cggcgcggag ccctcagtag tacacgacaa gcgttcagcg gcagcgggac
     8641 ttgaacggta gcgcccccca cgaggtgcgc cgggagccgt ttccgagtag tgacccgacc
     8701 gagttcgcgt cgccggagtc ggcttgccgc tggatcctgc agtacgagct atccaccacc
     8761 catagcgtct agaccgatgc ggtggcccgg attcttgtga gtacgcccaa tcgagaagac
     8821 ggattcgacc gaggtttccg tccccggctt ccggggtagt cgtcacgtgg caatgacgaa
     8881 tccaggacca tgaggtgcga ggacggcgtc ttctcggcct tgccgacggg gcgacactcg
     8941 tgttaaggct gaacgaaagt actccgcacg caggctgatg tgcacctgcg tcgcggtacc
     9001 ggaatcggtc cggatgacag ccgcagctgc gacgaatagg gtacgatgaa ggcgaatttc
     9061 ccagagaccg actggcggac gacgtcagtt cgactacgac gcaccggccc catgtcgcgg
     9121 tccgctcccg tatcgacggt tatcgataca gcgacggcca tcccggctgg gcactccgag
     9181 tacaacggtg gaagaaaacc ggtcaggctt gtgcccgtcg gagggagttc caccggagac
     9241 gtcgacgata cgcgggaccg gagcggcaca tgatcagcga tcagccagca gaaaaaccat
     9301 cggttgccga tgacggtgtc gtcgaggtgc atacgagcat cgactccgcc cagctcgccg
     9361 tactacgcaa tgtggctgcg accttgacga tggatgctgg tttcaccgtg gacagcgtcg
     9421 aggacgcccg gctgctcgtc gacgaggtct gctcgactct catccgcaac gcggagcgcg
     9481 gagctcagct gtcgtgccgg ttccgggccg atgaccgctt ctatctccac gcgcaggcca
     9541 ccgcaagccc ggatgccgtt gtcgaccgtt cttcgtggtc gtggcgcatc atgtcaacgc
     9601 tcgcggacac cctcatcagc tggacgaacg cgaatccggg gcagccgacg acgctgcaca
     9661 tcgaggcgac caaggcctct gacggatgcc catgaccgaa ggccctgacc acctcggcct
     9721 gtcgaaacag gccgagcacc aggagtacgc tcagttcgcg gaggacttcc acgaattcgc
     9781 tgcgctctca ccagagaatc cgcggtatga gcgcctgcgg gagaagctgg tccgcgagca
     9841 catgcccctc gctgagcaca tcgcgatgcg gttccgccac cgcggtgtgc agctcgagga
     9901 cctgcgtcag gtcgccatgc tcggcctgat caacgcggtg gaccggttcg aacccgatcg
     9961 cgggaacgac ttcctcgcgt tcgctgtgcc cacgatcatg ggcgaggtgc ggcggtactt
    10021 tcgcgacgcg ggctgggcca tgcgggtgcc gcgcaggctg caggaactgc atctgaatct
    10081 cggtaaagcg atcgacgagc tgtcccagcg caccggtcgc gcaccgcggg cggacgaact
    10141 tgccgagtac cttgggatcg aactcggcga ggtgcgcagg ggcctggagg cgggcagtgc
    10201 ttaccgggcc gattccctca acagcccggt cggcgggacc accgagtccg acagccaggc
    10261 cgtcagcgac accatcggcg agcaggacac caacatcgag gacgtcgagc tgcgcgaaac
    10321 gctacagccg ctgctggccg acctgccgga acgtgaacgg cgaatcctga ccctgcgatt
    10381 cttcggcaat ctcacccaat cggaaatcgc gcgcaagatc gggctttccc aaatgcacgt
    10441 ctccagattg ctcgcacaga gtctcaaaca gctgcgcgag cggatctacg gttgaccggc
    10501 ctggctcccg acacttccac agccggtcac ggtcccggca gttcgtacac ggcgaacgcc
    10561 cgtcctatca ccgaagcaca tatcgacgcc agtcatggcg tcgccaacga tgtgcctgcc
    10621 cgcgaaccgt acatcgcgcc cacgctcgac tatcgacgct gaatccggct taccgcacag
    10681 gagtagtcat gtccgaacac cagaccccgg ccagcgaaca cggggaacac ctcgaactcg
    10741 acgagaaccg ctcggccgcg cagccgctcg actggccacg agacgacccg cgcagggacg
    10801 accctgaaca cgacac
//
