LOCUS       NZ_KB905401            22755 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Sciscionella marina DSM 45152 A37UDRAFT_scaffold_28.29, whole genome
            shotgun sequence.
ACCESSION   NZ_KB905401
VERSION     NZ_KB905401.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Sciscionella marina DSM 45152
  ORGANISM  Sciscionella marina DSM 45152
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Sciscionella.
REFERENCE   1  (bases 1 to 69007)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Sciscionella marina DSM 45152
            collection_date                   :: SEP 2006
            lat_lon                           :: Missing
            depth                             :: 516 m
            alt_elev                          :: Missing
            country                           :: China
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 45152
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: 19196758
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Sand; Sediment; Marine; Aquatic
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11892
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site :: Marine sand sediment at a depth of about 500 m,
            the northern South China Sea
            Cell Shape                        :: Rod-shaped
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28 C
            pH                                :: 7
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000379465.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 01:37:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,209
            CDSs (total)                      :: 8,146
            Genes (coding)                    :: 7,961
            CDSs (with protein)               :: 7,961
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 1 of 185
            Pseudo Genes (frameshifted)       :: 52 of 185
            Pseudo Genes (incomplete)         :: 155 of 185
            Pseudo Genes (internal stop)      :: 15 of 185
            Pseudo Genes (multiple problems)  :: 34 of 185
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:59:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 15695
            Orig. end                         :: 38450
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905401.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405877
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22755
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22755
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22755
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12755](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12755
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            136..1329
                     /locus_tag="A37U_RS0124030"
     CDS             136..1329
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676190.1"
                     /locus_tag="A37U_RS0124030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CaiB/BaiF CoA-transferase family protein"
                     /protein_id="WP_040588669.1"
                     /transl_table=11
                     /translation="MTAPTPGPLDGVTVVSIEQAVAAPFATRQLADLGARVLKIERPGT
                     GDFSRGYDAAVKGTSSVFVWLNRGKESLTLDFKSEDGRELLERLLASADVFVQNLSPSA
                     AERAGLDPAAVQDRHPNLVVCGVSGYGSGGPLRDAKAYDLLVQGEAGMLSVTGTPEEMA
                     KVGVSIADISAGMYGYSGILAALMQRMRTGQAPPVEISLFDSLVEWLAYPLYYTHFGGM
                     TPTRMGVNHPTIAPYGAFEAKDGQWLLLAVQNDAEWRRFCDRVLGDPERAEDPRFATNS
                     DRVAHRSALDALIADRLVGTDGVAIRALLTEVGIANARITDIADLAGHPQLLERDRWIR
                     TPIPTGDVETVYPPGIPGQRRTDLGAVPLLGEHSDQVLTELGYSAEEIARLRQQQVI"
     gene            1368..1874
                     /locus_tag="A37U_RS45050"
     CDS             1368..1874
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039588.3"
                     /locus_tag="A37U_RS45050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MaoC family dehydratase"
                     /protein_id="WP_020499224.1"
                     /transl_table=11
                     /translation="MTVHTGWQGRFFEDFVLGDVYEHPLGRTITTTDNIWFTLLTQNTA
                     PLHFDHVYAARTDFGKPLVNSCLTLSLVAGQSVTDVSQNVYANLGWGQIELPHPVFEGD
                     TIRSRSTVLGTRPSQSRPTLGVVEVQTEGFTQSDDLVIRFTRTLLVYRTGHGPRATNGA
                     QEEQA"
     gene            1871..3031
                     /locus_tag="A37U_RS0124040"
     CDS             1871..3031
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676191.1"
                     /locus_tag="A37U_RS0124040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_020499225.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8e-22, bitscore:
                     70.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.4e-23, bitscore:
                     74.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.8e-37, bitscore:
                     119.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTTDTEVRADLRGLVDRVCADFPDAYWRELDDQLAYPEKFVDA
                     LTSTGVLGALVPEEFGGLGLEVGDASVIVEQINRNGGNAAAVHAQLYTMSSVLRHGSDE
                     QRKRYLPKIASGELRLQAFGITEPIAGTDTTKIRTFARRDGDSYILNGQKIWTSRLQHS
                     ELMLVLARTTPLEQVARKSHGLSLFLLDLREIEGITVRPIRTMVNHETNEVFYDDVRVP
                     ASALVGEEGQGFRYVLDSMNPERILVAAECIGDGRWFVERSSRYATERVVFDRPIGQNQ
                     GVQFPIARAHIHVEAADLMRWRAAELFDAGKECGAEANMAKLLAADASWEAANAALQTH
                     GGFGMASEYDIERKFREARLFQIAPISTNLILAHIGQHVLNMPRSF"
     gene            3031..4455
                     /locus_tag="A37U_RS0124045"
     CDS             3031..4455
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013676189.1"
                     /locus_tag="A37U_RS0124045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmgE/PrpD family protein"
                     /protein_id="WP_020499226.1"
                     /transl_table=11
                     /translation="MPEIAAEDILHGSNREAAPQTSETTPTRVLAEYVAQPPERVPQEA
                     IELARTAVLDTVGVALAAAREPVVSALGAVFGEISGPCVTWLDGRSADPSRTALRNATA
                     AHALDFDDVDDLFTGHPSAVLVPAVLAVAEQTEASGALAAEGYWRGLTVIRALAAGLGV
                     GEHYTRGWHSTATLGVLGASAAAATVLGLNAQQTAHALGIAVSRAAGSRHNFGSMTKPL
                     HAGLAASDGVLAAVLAQAGLTAGSDPVGGPYGYLGLYSGAATLTEAQRSAATERIVATL
                     RDPGRAALNLKLFPCCYATNAAADAALELQASGLRIEDIDTVQVAVPAGGLQPLIESAP
                     RTGLEAKFSVHYVVASCLADGHLRLDAFTDAAVDRAPVLDLAARITATDTLPTVQTGRL
                     VFAAETTVRTRTGDTTAIRCDAPRGHADRPARMADVLAKFDDCVAFGGANVPTDLAERL
                     HGLPERPNVAGIFTDQ"
     gene            4611..5666
                     /locus_tag="A37U_RS45055"
     CDS             4611..5666
                     /GO_function="GO:0016624 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, disulfide as
                     acceptor [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313901.1"
                     /locus_tag="A37U_RS45055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_020499227.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 3.3e-07,
                     bitscore: 21.8, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPVQLLDPDGRLTQDENWPLELTPELCRDLYRRMRLARRFDEQA
                     YVLQRQGELGLWLQSLGQEAAQVGSISAVRPDDHVFPSYREHAAALCRGITPAELLVQW
                     RGSRNSGWDPATYRFHIYTLVLAAQLPHATGYAMGVQRDGTDEIVLAYFGDGAASEGEA
                     NETFNWAATTEVPLLLFCQNNQWAISTPAHTQTRTSLHQRAQGFGLEAHLVDGNDILAV
                     HAVTAAVAERVRSGGGPAMIEAQTYRMAGHSTSDDPDRYRDASELDSWKTRDPIHRLER
                     LLEERGWMNDGFRADLEAECEVFANRTSQECKQLPLQDVSTLFNTVLAEPTPLLTEEHR
                     RYAELVASFAE"
     gene            5727..6710
                     /locus_tag="A37U_RS0124055"
     CDS             5727..6710
                     /EC_number="1.2.4.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313899.1"
                     /locus_tag="A37U_RS0124055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="WP_020499228.1"
                     /transl_table=11
                     /translation="MSQLTLSKALNTGLQQALTNDPKVIVMGQDVGGLGGVFRVTDGLQ
                     KDFGPQRVIDTPLAEASIVGTAIGLALRGYRPICEIQFDGFVYPAFNQIVSQLAKMRAR
                     SHGQLALPVVIRIPVGGGIGAVEHHSESNEVYFAHTAGLRVVCCSNPQDGHWMLRQAVA
                     SEDPVIFYEPKRRYWAKDEVTDTPAESTLPLDRARILRSGDDLTLLTYGGMVDTCQRAA
                     AVAAEEDRREIEVVDLRTLSPLDMETIAASVGKTGRCVVAHEAPTFAGLGAEVGAEITE
                     YSFYDLQAPVLRVGGFNIPYPPAKYEDQHLPDLDRVLDAVDRSFAW"
     gene            6718..7980
                     /locus_tag="A37U_RS0124060"
     CDS             6718..7980
                     /EC_number="2.3.1.-"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313898.1"
                     /locus_tag="A37U_RS0124060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrolipoamide acetyltransferase family
                     protein"
                     /protein_id="WP_020499229.1"
                     /transl_table=11
                     /translation="MNTSAKSQQFHLPDVGEGLEEAEIVTWHVAVGDSIGNNQPLAEIE
                     TAKSLVELPSPYEGTVLEILAEPGQTVRVGEPVVSIGTATEEPAEPAPEVLVGYGPGTS
                     APARRRRRQTSQEQPPVARSVQPNAARAKPPVRRHAKQMGIDIETVTATGPYGTVTRQD
                     LLRHADRATDHLPDPAPMAQAATRPDNEARRTPVTGVRKATAAAMTTSAFSAPHASEYH
                     VVDVTRSVKLVGQLKTHPAFGQSKVSMLLPVARALLAAVSEHPAINASWADTEILEHPA
                     VNLGIAAATPRGLLVPNIKNAQSLTLPSLARAITELVDTARKGRSSPQEMTGGTITITN
                     IGIYGIDAGTPILNPGEAAILCLGAVRRLPWEHNGRIELRWVTRLTLSFDHRIVDGELA
                     SKALSRIGQILHRPKTELLLT"
     gene            8640..8894
                     /locus_tag="A37U_RS0124065"
     CDS             8640..8894
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0124065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020499230.1"
                     /transl_table=11
                     /translation="MHAHENLDWRPTILGTVEDLSAVLLSTALGEHARAQLSLLPPEFP
                     TSPQLVPAELPDTGVTEAITLLAHLIAMAAAEGQVDDEE"
     gene            complement(9163..9777)
                     /gene="mftR"
                     /locus_tag="A37U_RS0124070"
     CDS             complement(9163..9777)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082061.1"
                     /locus_tag="A37U_RS0124070"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_020499231.1"
                     /transl_table=11
                     /translation="MTTPHRDTDARRRGRPPATNARELELAALRLFSEHGFDDTTVEEI
                     AAVAGVSRRTFFRYFDSKSAALWHQFDGEVQRLRTAFDAVSPHTPLMDAIREVVVGVNH
                     YRAEDVPELRTRMHLISTVPALQTSAGPHYDAWERAVSDFAARRLNQPPDTLYPLAIGR
                     TTLAASRAAFDQWLTTADTDLTTYLDLSLHALANGFDTRTR"
     gene            9885..10001
                     /gene="mftA"
                     /locus_tag="A37U_RS49165"
     CDS             9885..10001
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947188.1"
                     /locus_tag="A37U_RS49165"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_020499232.1"
                     /transl_table=11
                     /translation="MADDSRVAVGENDVDAPDVVTSDLLVEEVSIDGMCGVY"
     misc_feature    complement(9913..9928)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.37"
                     /tool="antismash"
     gene            10001..10300
                     /gene="mftB"
                     /locus_tag="A37U_RS50045"
     CDS             10001..10300
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010310366.1"
                     /locus_tag="A37U_RS50045"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_083933808.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 4e-29,
                     bitscore: 92.8, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDPQHDPILDQAWVLSPSVALRPEPFGALAYHFGNRKLTFLKRR
                     ELVVLVETLGEHPDVRSALVAAGVPEVEYGAYCSALHSLAGTDMVRPRTREVAA"
     aSDomain        10031..10270
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A37U_RS50045_Mycofactocin_RRE.1"
                     /evalue="1.80E-29"
                     /identifier="RREFam016.1"
                     /label="A37U_RS50045"
                     /locus_tag="A37U_RS50045"
                     /protein_end="90"
                     /protein_start="10"
                     /score="92.8"
                     /tool="antismash"
                     /translation="DQAWVLSPSVALRPEPFGALAYHFGNRKLTFLKRRELVVLVETLG
                     EHPDVRSALVAAGVPEVEYGAYCSALHSLAGTDMV"
     gene            10297..11529
                     /gene="mftC"
                     /locus_tag="A37U_RS0124085"
     CDS             10297..11529
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010229643.1"
                     /locus_tag="A37U_RS0124085"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_020499234.1"
                     /sec_met_domain="PTHR43273 (E-value: 1.2e-40, bitscore:
                     131.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.3e-25, bitscore: 81.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 2.5e-10, bitscore: 32.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.7e-16, bitscore:
                     50.8, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.2e-06, bitscore: 21.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVQERPVGGSLVDQFELGLDAPICLTWELTYACNLECAHCLSS
                     SGRRDPRELSTEQCEAVIDELQRMQVFYVNIGGGEPTIRPDFWHLLEYAVDHQVGVKFS
                     TNGVRITPERARFLASTDYVDVQISLDGATAEVNDYVRGPGSYDTALTALRNLQEAGFE
                     DAKISVVCTRENIGQLDEFKALADRFGATLRLTRLRPSGRGADVWDELHPLPGQQKVLY
                     DWLIAHGEDVLTGDSFFHLAAFGEKLPGLNLCGAGRVVCLIDPVGDVYACPFAIHENFL
                     AGNVLSDGGFQRVWQASELFTELRSPQTGGACAKCSFYDACRGGCMAAKFFTGLPLDGP
                     DPECVRGLGESALAGERTVPPASRDHSKAAPTRNQPVMLTLLSRPPVSACAESPLADYA
                     PGAPEQKGCCA"
     gene            11526..12755
                     /gene="mftD"
                     /locus_tag="A37U_RS0124090"
     CDS             11526..12755
                     /EC_number="1.4.3.26"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR03966"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020418891.1"
                     /locus_tag="A37U_RS0124090"
                     /note="MftD, an enzyme found in the mycofactocin
                     biosynthesis locus, performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases; Derived
                     by automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="pre-mycofactocin synthase MftD"
                     /protein_id="WP_020499235.1"
                     /sec_met_domain="TIGR03966 (E-value: 4.5e-196, bitscore:
                     642.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLENPWKRNPWFESVAVAKRRARKRLPAPVYGALVAGSERGQTI
                     DDNEAAFREVGFAPHVAGQRPERSMATTVLGQDVSLPVLISPTGVQAVHPEGEVAVARA
                     AAARATVMGLSNFASKSVEEVTATGAPTFFQMYWTGDRDVMIQRMRRAHAAGVIGLIAT
                     LDWSFSMGRDWGSPEIPEKVDLKTMVRMAPKVVTKPRWLYEFGRTGQIPDLTAPNLAPP
                     GGAAPTFFGAYHEWMTTPPPSWADVAWMREQWAQISGTPFVLKGVCRIDDALRARDAGV
                     SGLSVSNHGGNNLDGTPGAIRMVKPIADAVGYDVEVVTDGGIRRGSDVVKALALGARSV
                     LIGRAYLWGLAANGQTGVENVLDVLRSGIDSALMGLGVASIDELTPEHLLVPPGFERRL
                     GAPTPEVAGR"
     gene            12752..13423
                     /gene="mftE"
                     /locus_tag="A37U_RS45060"
     CDS             12752..13423
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: protein motif:HMM:TIGR03964.1"
                     /locus_tag="A37U_RS45060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_020499236.1"
                     /transl_table=11
                     /translation="MTGHLTHATWPEIDHVELILVPVGSIEQHGPHLPLDTDTAIATAV
                     AQGVAEIVDGAWVAPAIVYGSSGEHQAFPGTSSIGTEALQLLLIELVRSMRTWARRVLF
                     VNAHGGNLPALDRAIGQLVDEDHDVTWTPCAIDDSDLHAGRTETSLMLHLRPRSVRLDR
                     MEQGNTGSLQQLLPALVREGVGGVSANGVLGDPAGATAEEGEQTLARMVQTIATRTTAA
                     V"
     gene            13420..14184
                     /locus_tag="A37U_RS0124100"
     CDS             13420..14184
                     /NRPS_PKS="Domain: PKS_KR (3-168). E-value: 1.2e-13. Score:
                     43.3. Matches aSDomain:
                     nrpspksdomains_A37U_RS0124100_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017983860.1"
                     /locus_tag="A37U_RS0124100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_020499237.1"
                     /transl_table=11
                     /translation="MTRVAIVTGAARGIGAATVARLAADGYQIMAVDSCEGPPLASRAE
                     LDALTAAHSDNVVAHIADVRDRSALAKAVTRTLEHWHRLDVVVACAAVMRGGAPLWETP
                     DTDLDLLWEVDAKGVWNTAATTVPAMLTGPDPSGCRFVAIASAAGTHGMFHLAAYNAAK
                     HAVVGIVKGLAADLVATGVTACAVSPGSTNTPMLQTTADLYSVTIDELTDHQLIRQPID
                     PAEIADTIALCASPAGRVLNGSVVHADGGFAS"
     aSDomain        13429..13923
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0124100_PKS_KR.1"
                     /evalue="1.20E-13"
                     /label="A37U_RS0124100_PKS_KR.1"
                     /locus_tag="A37U_RS0124100"
                     /protein_end="168"
                     /protein_start="3"
                     /score="43.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAIVTGAARGIGAATVARLAADGYQIMAVDSCEGPPLASRAELDA
                     LTAAHSDNVVAHIADVRDRSALAKAVTRTLEHWHRLDVVVACAAVMRGGAPLWETPDTD
                     LDLLWEVDAKGVWNTAATTVPAMLTGPDPSGCRFVAIASAAGTHGMFHLAAYNAAKHAV
                     VG"
     CDS_motif       13435..13491
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A37U_RS0124100_0001"
                     /evalue="3.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="A37U_RS0124100"
                     /protein_end="24"
                     /protein_start="5"
                     /score="9.9"
                     /tool="antismash"
                     /translation="IVTGAARGIGAATVARLAA"
     gene            14181..15662
                     /gene="mftF"
                     /locus_tag="A37U_RS45065"
     CDS             14181..15662
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03965.1"
                     /locus_tag="A37U_RS45065"
                     /note="Members of this protein family, MftF, are
                     glycosyltransferases, members of PF00535 (glycosyl
                     transferase family 2). The encoding gene is found as part
                     of the mycofactocin cassette, in Mycobacterium
                     tuberculosis, many other Actinobacteria, and occasional
                     members of other lineages. Mycofactocin itself, a putative
                     redox carrier, is a heavily modified derivative of the
                     C-terminal Val-Tyr dipeptide of the mycofactocin precursor
                     MftA (TIGR03969); Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="mycofactocin biosynthesis glycosyltransferase
                     MftF"
                     /protein_id="WP_157183007.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.4e-23,
                     bitscore: 73.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTPARLPDGFEVRIREDVTRLANGHVLVGGTPLRALRLTDAAT
                     ALIEHDRIRVVDPASAALARRLLDANIADPVLSAAVPNHVLTVIIPVRDRPEQLDRALS
                     ALYPLPVVVVDDASTDPETVAQTAARHDAHLITLQLNQGPAGARNAGLAHVTTPYVAFV
                     DSDVEITADALLRLTRHFTDPCVAMVGPRIIGIARTTRPRWHERYDESASSLDLGDRPC
                     SVQPGATVAWIPSACLLARISQLGDGFDPDLRIGEDVDLVWRLTTSGHTIRYDPTITAQ
                     HDTRPTLTGWLERKFAYGTGGATLAQRHGTHTAVARLSPAMALAATALLTRHRYSIPIA
                     VVCLAYSTGSLARSLPDAVRGTGLANRLAIRGLGWSLRQESALLLRHWWPATLLAALTN
                     RTARRALTTAAIIDLITAKPGSNQNPLNTFLGRRIDDLAYGAGLWWGAINIRSPKTLAI
                     RWIRVRQKPNLHAGLSARGNCPSRAVSAHGVSYRL"
     gene            16003..17557
                     /locus_tag="A37U_RS54715"
                     /pseudo=""
     CDS             16003..17557
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079337.1"
                     /locus_tag="A37U_RS54715"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="FAD-dependent monooxygenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MASVRAERDLLIGLDSLLVERRPATTTHPKARVCHPRTMEQFGVW
                     GIENRVRRAGLPQESDVACWCGSLNGPLVAYTDPAPTLHRGRSCPRRRWKRRWTMRCPP
                     GHGHGCAG"
     misc_feature    16036..16051
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    17188..17190
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17763..17915
                     /locus_tag="A37U_RS53870"
     CDS             17763..17915
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS53870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020499241.1"
                     /transl_table=11
                     /translation="MLLDHSWAPRSLFGLLVVPLVVVAGAVIVITLPRRRLRKVVPTEV
                     PAQLP"
     misc_feature    17941..17952
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            17945..19012
                     /locus_tag="A37U_RS45075"
                     /pseudo=""
     CDS             17945..19012
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417242.1"
                     /locus_tag="A37U_RS45075"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKAVRLRDYHKQPTVEEVPEPVLSGPLDVIVRIGGAGVCRTDLHI
                     TEGQWAQAMGPGNGPRQWARGCPTPWDTRTRAGCTRSAPASPTSRSATP"
     gene            complement(19410..20063)
                     /locus_tag="A37U_RS45080"
     CDS             complement(19410..20063)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333381.1"
                     /locus_tag="A37U_RS45080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_051111725.1"
                     /transl_table=11
                     /translation="MTAQPRTPLRSDARDNRERILAVARAVFAAEGIDVPIREIARCAQ
                     VGVATVYRHFPTKDVLLAAAFADQRPSCASIVEDGLAHDDPWRGFGLVIEKLLEVHARD
                     RGSASRLPGTVDLVAERDRTLRQLLDLIRSAKDTGELRADFVLEDLVLALMTNEGIQAA
                     TPQLRAATSRRFAALMIQSFQTRPNLTTLPPAVPLPLISEQATHHPHVRPKTRS"
     gene            20113..21087
                     /locus_tag="A37U_RS0124130"
     CDS             20113..21087
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (16-243). E-value: 4e-27. Score:
                     87.1. Matches aSDomain:
                     nrpspksdomains_A37U_RS0124130_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666108.1"
                     /locus_tag="A37U_RS0124130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_026197543.1"
                     /sec_met_domain="ADH_N (E-value: 3.5e-08, bitscore: 25.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.5e-13, bitscore:
                     41.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVQFNEYGPPTVMQVATVEEPHTGPGQIRIGVRASGLTTGEVR
                     VRSGALRAMVPVSLPYRTGFDAAGVVDEVGEGVAGVSIGDEVFGMTASATRGANADFAV
                     LVAWAPRPAVWTWEEAGGAAGSVETATRVLDRLALGAEQTVLVQGAAGATGSVVVQFAL
                     ARGATVIGTASEHNRQFLQSLGVVPTTYGPGLVERVRALAPSGVDAVIDCAGGALPDLV
                     TIVGDAERVVTIADLDAAAYGVHLSHGAPNDAPTDGTGATTVPHADPLALHGLTTAVTL
                     ADKGLLRVPVAAAFPLDQVAEAHALSEGRHAPGRIILTNTARR"
     aSDomain        20161..20841
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0124130_PKS_ER.1"
                     /evalue="4.00E-27"
                     /label="A37U_RS0124130_PKS_ER.1"
                     /locus_tag="A37U_RS0124130"
                     /protein_end="243"
                     /protein_start="16"
                     /score="87.1"
                     /tool="antismash"
                     /translation="VATVEEPHTGPGQIRIGVRASGLTTGEVRVRSGALRAMVPVSLPY
                     RTGFDAAGVVDEVGEGVAGVSIGDEVFGMTASATRGANADFAVLVAWAPRPAVWTWEEA
                     GGAAGSVETATRVLDRLALGAEQTVLVQGAAGATGSVVVQFALARGATVIGTASEHNRQ
                     FLQSLGVVPTTYGPGLVERVRALAPSGVDAVIDCAGGALPDLVTIVGDAERVVTIADLD
                     AAAYG"
     CDS_motif       20539..20598
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A37U_RS0124130_0001"
                     /evalue="3.00E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="A37U_RS0124130"
                     /protein_end="162"
                     /protein_start="142"
                     /score="13.5"
                     /tool="antismash"
                     /translation="QTVLVQGAAGATGSVVVQFA"
     gene            complement(21760..22551)
                     /locus_tag="A37U_RS0124135"
     CDS             complement(21760..22551)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639865.1"
                     /locus_tag="A37U_RS0124135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_026197544.1"
                     /transl_table=11
                     /translation="MSGKVSGTYRARNSTADRALDILSMFTDTEPVLSGAAVADRLGVA
                     RSTAYRYLQSLVATRFLEEAPEGGFRLGLRILEIARVARRSYGLSEAAMPIMTGLCEAT
                     GETILLTRRVGDLVVCVERAESRTRAARISYEPGSTLAVNAGASALALLAWSPPEQARA
                     VLESAAPFRQFTPATLTDVDDLMKRLVTIRADGYSITRAELDPDVLGIAAPIRNSADDV
                     VAAVSVAALATRVDTSAEAKFIELVLDAARAISERIAAIND"
ORIGIN
        1 cggcagcgcg gtgtgtcggc tcgacgacgg cacctttgtc gacgagccga tcctgcggcg
       61 cgcaaaggcg ttgcttgacg actaccctga tacgcggcaa agggcagttg cgcgaggggc
      121 ttcggcggtg aacccgtgac ggcgccgacg ccgggtccat tggacggggt gactgtggtg
      181 agcatcgagc aggcagtggc ggctccgttt gccacgcggc aactggccga tctcggagcc
      241 cgggtcctga agatcgagcg gccaggtacg ggcgacttct cccgcggtta cgacgccgcc
      301 gtcaagggca cttcgagcgt attcgtatgg ctcaaccgtg ggaaggagtc cctgacgctg
      361 gacttcaagt ccgaggacgg ccgcgagctg ctggagaggc tgttggcgag cgcggatgtg
      421 ttcgtgcaga atctgtcgcc gtcggcagca gagcgggctg ggctggatcc cgccgctgtg
      481 caggaccggc atccgaatct ggtcgtctgc ggggtatcgg ggtacggctc tggcggaccg
      541 ctgcgcgacg cgaaagccta cgacctgctc gtgcaggggg aggcggggat gctctcggtg
      601 accgggacac cggaggagat ggctaaggtg ggagtgtcga tcgctgatat atccgcagga
      661 atgtacggct attccggcat tctcgcggcg ctgatgcagc ggatgcgaac cggtcaggca
      721 ccgccagtcg agatttccct gttcgattcg ttggtggaat ggctggcgta tccgctgtac
      781 tacacccatt tcggcgggat gacgcccacc agaatgggtg tcaaccatcc cacgatcgct
      841 ccgtacggtg ccttcgaagc gaaagatggg cagtggctgc tgcttgcggt gcagaacgac
      901 gccgagtggc ggcgcttctg cgaccgggtc ctcggcgatc ctgaacgggc tgaggatccg
      961 cggtttgcca ccaacagcga ccgcgtagca caccggtcgg cgctggacgc gctgatcgcg
     1021 gatcgtctgg tcggcaccga cggcgtcgcc atccgagcgc tgctcaccga ggtgggaatc
     1081 gccaacgcgc ggatcaccga catcgccgac ctcgccggac acccacagct gctggaacgg
     1141 gaccgttgga tacggactcc gatcccgacc ggcgatgtcg agaccgttta tccgccggga
     1201 atcccggggc aacgccgaac cgatctcggt gcggtcccgt tgctcggtga gcactccgac
     1261 caggtgttga ccgaactcgg ctactcggca gaagagatag cccggctgcg ccagcagcag
     1321 gtgatctgac ccgttcctgt cccaggagct ttcgcggaag gcatgacatg accgttcaca
     1381 ccggatggca aggccgcttc ttcgaggact tcgttctcgg cgatgtgtac gagcacccgc
     1441 tcgggcgcac catcaccacc acagacaaca tctggttcac cttgttgact cagaacaccg
     1501 caccgttgca tttcgaccac gtgtacgcgg cacggaccga cttcggcaag ccactggtca
     1561 actcctgcct cacgctgtca ctggtcgctg gccagagtgt cacggatgtc tcgcaaaacg
     1621 tctacgcaaa cctcggctgg ggacagatcg aactcccaca ccccgtgttc gaaggtgaca
     1681 ccattcgctc acgcagcact gtcctcggca cccgcccctc gcagtcgagg cccacgctcg
     1741 gtgtggtcga ggtgcagacc gagggcttca cccagagcga cgacctcgtc atccgcttca
     1801 ccaggacact gctggtctat cgaaccgggc acggaccgcg agctacaaac ggcgcacagg
     1861 aggagcaagc atgagcacca ccaccgatac cgaggtccgc gccgacctgc gtgggcttgt
     1921 cgaccgggtc tgcgcggact tccccgacgc gtactggcgc gaactcgacg accaattggc
     1981 atacccggag aagttcgtcg atgcgctcac ctcgaccgga gtgctcggcg cactggtccc
     2041 cgaggaattc ggcggacttg gcctcgaggt cggcgatgcc tcggtgatcg tcgagcaaat
     2101 caaccgcaac ggtggcaacg ccgccgcggt gcacgctcag ctgtacacga tgagctccgt
     2161 gctgcggcac ggttccgacg aacagcgcaa gcgttacctg ccgaagatcg ccagcggcga
     2221 gctgcggctg caagccttcg gcatcactga accaatcgcc ggcaccgata ccaccaagat
     2281 ccgcaccttt gcccgccgag atggcgactc ctacatcctc aacggtcaga agatctggac
     2341 ctcacgcttg caacactccg agctgatgct ggtactggcc aggacaaccc cgctggagca
     2401 ggtcgcgagg aagtctcatg ggctgtcgct gtttcttctc gatctgcggg agatcgaggg
     2461 aatcacggtc cggccgattc gaaccatggt caaccacgaa accaacgagg tcttctacga
     2521 cgacgtgcgt gtgcccgctt ccgcgcttgt cggagaagag ggacagggct ttcgctacgt
     2581 gctcgacagc atgaaccccg aacggatcct cgtcgcggcg gaatgcattg gcgatggtcg
     2641 ctggttcgtt gagcgctcca gccgctacgc caccgaacga gtagtcttcg accgcccgat
     2701 cgggcagaac caaggcgtac agtttccgat cgcccgcgca cacatccatg tcgaggcagc
     2761 cgacctgatg cgctggcgcg cggccgagct gttcgacgcg ggcaaagagt gcggcgccga
     2821 ggcgaacatg gccaagctgc tcgccgcaga cgcatcctgg gaagcggcca acgccgcgct
     2881 gcaaacccat ggcggattcg gcatggcctc cgaatacgac atcgaacgca agttccgcga
     2941 agcacgcctg ttccagattg cgcccatctc gaccaacctc atcctcgccc acattggcca
     3001 gcacgtgctc aacatgccga ggtcattctg atgcccgaga tcgcagcgga ggatatcctg
     3061 cacggctcaa accgggaggc tgcgccacag acgagcgaga ctaccccgac ccgggtcctg
     3121 gccgagtatg tcgcgcagcc accggagcgg gtaccccaag aggcaataga gctagcccgc
     3181 accgcggtgc tcgacacggt tggcgtcgcc ttggcagccg cccgcgaacc cgtagtctcg
     3241 gcgctgggcg ctgtattcgg cgaaatcagc ggcccctgcg tgacctggct cgacggccgt
     3301 agcgctgacc caagcaggac cgcactgcgc aacgccaccg ccgcacacgc ccttgacttc
     3361 gacgacgttg acgacctgtt caccggtcac ccgagcgccg tgctggtgcc cgcagtgctg
     3421 gccgtcgctg aacaaaccga agccagcggt gcactcgccg cggagggcta ctggcgtggc
     3481 cttaccgtga tacgggcgct ggccgctgga cttggcgtcg gtgaacatta cacccgaggc
     3541 tggcactcca ccgcgaccct cggcgtgctc ggcgcttcgg cggcggccgc cacggtactg
     3601 ggcctgaacg cgcagcagac cgcgcacgca ctgggcatcg ccgtatcccg cgcagccggg
     3661 tcgcgacaca acttcgggtc gatgaccaag ccactgcacg ccgggctcgc ggcaagcgat
     3721 ggagtgctcg ccgccgtact ggcacaggcc ggactcaccg ctggaagtga cccggtcggc
     3781 ggcccatacg gctatctcgg cctgtactcc ggagcagcca ccctcacgga ggcacagcgc
     3841 agcgccgcca ccgaacgcat cgtcgcgacg ctgcgcgacc cgggccgcgc agcgctcaac
     3901 ctcaaacttt tcccatgctg ctacgcaacc aacgccgccg cagacgccgc actcgaacta
     3961 caagcatccg ggttgcggat cgaagacatc gacacagtcc aggtagccgt acccgcaggg
     4021 ggcctgcagc cactgatcga atccgctccc cggacgggat tggaagccaa attcagcgtc
     4081 cactacgtcg tcgcgtcttg cctcgccgac gggcacctca gactcgacgc gttcaccgac
     4141 gccgcggtcg atcgcgcacc ggtgctggac ctcgccgcac gcatcaccgc taccgacacc
     4201 ctcccgactg tgcagaccgg caggctggtg ttcgccgcgg agactaccgt gcggacccga
     4261 accggtgaca cgacggcaat ccgctgcgac gcaccccgcg gacacgccga tcgtcccgcg
     4321 cggatggcag atgtgctggc caagttcgac gactgcgtcg cgttcggtgg cgcaaacgtt
     4381 cccaccgacc tcgccgaacg cttgcacgga ctaccggaac ggccgaacgt ggcaggcatc
     4441 ttcactgatc aatgaccacc gatgacggcg acacccgacg ccaccgcgtc gacggtccgt
     4501 ggccgtcctc cggcaccttc gtggttgcgc ttcgccaacc ggcggggcat ccacggccgc
     4561 agcgctccac agggcgctgc ggccaaccga tcaatcctag ggagaaccgc atggaacccg
     4621 tgcagctact cgaccccgac ggccgcttga cccaggacga gaactggccg ctagagctca
     4681 cccccgaact atgtcgcgac ctgtaccgca gaatgcgcct cgcgcgtcgg ttcgacgaac
     4741 aggcatacgt cctgcaacgg caaggcgagc tcggcttgtg gctgcagtcg cttggtcagg
     4801 aggcggctca ggtggggtcg atcagcgcag tgcggcccga cgaccatgtg ttcccgagct
     4861 accgcgagca cgccgccgcg ctgtgccgcg gtatcactcc ggcagagttg ttggtgcagt
     4921 ggcgcggtag ccgcaacagc ggatgggatc cggcgaccta tcgtttccac atctacactc
     4981 tggttctggc cgcgcagcta ccgcacgcga ccggttacgc gatgggcgtg cagcgcgacg
     5041 gcacagacga aatcgtgctc gcctatttcg gtgacggagc ggccagtgag ggtgaagcga
     5101 acgagacctt caactgggcg gccacaaccg aggtaccgtt gctgttgttc tgccagaaca
     5161 atcagtgggc tatctccaca cctgcgcaca cccagacgcg cacatcgctg caccagcgtg
     5221 cgcagggttt cggcctcgaa gcccacctcg tcgacggcaa cgacatcctg gccgtacacg
     5281 cggtgaccgc tgcggtcgcc gagcgcgtgc gcagcggggg aggcccggca atgatcgaag
     5341 cgcaaaccta ccggatggcc ggccacagca cctctgacga cccagaccgc taccgcgacg
     5401 cgagcgaact ggacagctgg aagacccgcg acccgatcca tcgcctcgag cggctgctcg
     5461 aggaacgcgg atggatgaat gacggattcc gcgcggacct ggaagccgag tgcgaggtgt
     5521 ttgccaaccg tacaagccag gaatgcaagc agttgccact gcaagacgtg tccacactgt
     5581 tcaatacggt cctggccgag ccgactccct tgttgaccga ggaacaccgg cgctacgccg
     5641 agctggtcgc ctctttcgcg gagtaagcct ctgcacctct ttccgcactg gccgcaccga
     5701 cctacggccc tatcgacggg aaatccatgt ctcagctcac tctttccaag gcgctcaaca
     5761 ccggcctgca acaggcgctt accaacgacc ccaaagtgat cgtcatgggc caggacgtcg
     5821 gcggactcgg cggagtcttc cgcgtcaccg acggcctgca gaaggacttc ggcccacagc
     5881 gcgtgatcga tacccctctc gccgaggcga gcattgtcgg caccgcaatc ggactagcgc
     5941 tgcgcggtta tcggccaatc tgcgagatcc agttcgacgg cttcgtctat cctgccttca
     6001 accagatcgt ctcccaactg gcaaaaatgc gagcccgcag ccacggccag cttgcgctgc
     6061 ccgtggtgat ccgcattccg gtcggcgggg ggatcggcgc cgtggaacac cacagcgaat
     6121 caaacgaggt gtactttgcg cacaccgcgg gactccgcgt ggtgtgctgc tcgaacccac
     6181 aggatggcca ctggatgctg cggcaggccg tcgcctccga ggacccggtc atcttctacg
     6241 agcctaaacg gcgctactgg gccaaagacg aggtcaccga cacacccgcc gagtcaacgc
     6301 tgccacttga tcgggcacgg atactacggt cgggagacga cctgacactg ctcacctacg
     6361 gcggcatggt ggacacctgc caacgggccg cggcagtcgc ggcggaggaa gaccgccgtg
     6421 agatcgaggt tgtcgacctg cggaccctgt ccccactgga tatggagacg atcgcggcct
     6481 cggtgggcaa gaccgggcgc tgcgtcgtcg cccatgaggc accgaccttc gcgggactcg
     6541 gcgccgaggt cggcgccgag ataaccgaat actcattcta cgacctccag gcccccgttc
     6601 tgcgggtcgg tggattcaac atcccctatc cacccgccaa gtacgaggac cagcacctcc
     6661 ccgacctcga ccgggtcctc gacgcggtcg accgatcgtt tgcgtggtga gccacccatg
     6721 aacacctctg cgaaatccca acaatttcac ctacccgatg tcggcgaggg actcgaagaa
     6781 gccgagatcg tcacctggca tgtcgcggtg ggcgactcga tcggcaataa ccagccactc
     6841 gctgagatcg agaccgccaa atcactggtg gaactgccgt ccccatacga gggcaccgtc
     6901 ctggaaatcc tggccgaacc ggggcagacc gtacgggttg gcgagccggt cgtctccatc
     6961 ggcactgcca cggaagaacc ggccgaaccc gcgccggaag tgcttgtcgg ctacggccct
     7021 ggtacgagcg ctccggctcg aaggcgccgc aggcagacct cgcaggagca gccacccgtg
     7081 gcgcggtccg tacaacccaa cgcagcgcgg gcgaaacccc cggtccggag acacgccaag
     7141 cagatgggca tcgacatcga gaccgtcacc gcgaccggac cctacggcac tgtcacacgc
     7201 caagatctgc tccgacacgc cgaccgggcc acagatcatc tacccgatcc cgcaccgatg
     7261 gcacaagcag cgacccggcc agacaacgag gctcggagga ccccggtcac cggagtacgt
     7321 aaggccactg cggcggcaat gaccactagt gcgttcagcg caccacatgc tagcgagtat
     7381 cacgtcgtcg acgtgacacg atcggtaaag ctggtcggcc agctcaaaac ccaccccgcg
     7441 ttcgggcaat cgaaggtctc gatgctgctg ccggtggctc gtgccctcct ggccgcggta
     7501 tccgagcacc cggccatcaa cgcgtcctgg gcagacaccg agatcctcga acaccccgct
     7561 gtcaacctgg gaatcgcggc cgcaacgccc cgtggactgc tggtacccaa catcaagaac
     7621 gcccaatcgc tgaccctgcc cagccttgcc cgcgccatca ccgaactggt tgataccgcc
     7681 cgcaaagggc gatcgagccc acaggagatg accggtggca cgatcaccat caccaacatc
     7741 ggcatctacg gtatagacgc cggaacgccg atcctcaacc ccggcgaagc tgccatcctg
     7801 tgtctcggag cggtgcgcag gctcccctgg gaacacaacg gccggatcga actgcgctgg
     7861 gtcactcggc tcaccctctc gttcgaccac cgcatcgtcg acggcgagct cgcaagcaag
     7921 gcgctcagca gaattggcca aatcctgcac cgaccgaaaa ccgagctact gctgacctga
     7981 ccaaggagag cgcgcatcga gggagtgtcc ggcgaacggc tctggctcaa atccggtcgt
     8041 aacttattgt gacggttagt tgcattcggt aacagcagga atcgcggtgc tctggcctcg
     8101 atgttccgtg ggcggatagt gtcgcaatca ggctgcgacc tcggtgtgtc ggtgcgccgc
     8161 agaggccgtg gcgcaagctc gccaactctc acccgatggc agctcggcat ccgtgacctg
     8221 cggatcctta cttcgccaga gccttatcgt tgtgactacc gtccgtcacc accgaaagtg
     8281 cgtcagagcc ccatcgacat cacaaactgt cgttgcagta ctaagtcttc gcggatccag
     8341 atacgacgga ccggcacatg gtactgacca tgatgcaagg cggggccgac gagatcagcg
     8401 tccccaacgg gccgtggaaa ttcgacggcc agccgcccgc cgctggggct ccgtcaacac
     8461 accgccgagg tcgtcgccga gctgacagag ctgaggttcg gtggagagcc ggtatgggtt
     8521 gattgaacgg taggtgggtc agcgccgcgg aacgttgtgt cgatgcaagg ttcggcacac
     8581 cgtgacgcgg agacggtgaa cacgtcgaca aggtcggcga tggtgtactc gccagtaccg
     8641 tgcatgcgca cgagaatctc gactggcggc caacgatctt gggcacggtc gaagatctgt
     8701 cggcggtgct gctgtcaacg gcactggggg aacacgctcg tgcccagctc agtctgctcc
     8761 cgcccgagtt tccgacgtca ccgcagctgg tgccggccga gctgcccgac accggcgtga
     8821 ccgaggccat cacgttgctg gcgcacctga tcgcgatggc agcggccgag ggccaggtgg
     8881 acgatgaaga gtgagcacac caaggtgacc gcatcccacc gctcccgcgc ggcggtcgtc
     8941 tacgttcgcc aatccacgcc tacgcaattg gggcgcaacg ccgagtccat tgcccgacga
     9001 tacgacctgg tcgagtgtgc catcatgctg agctggttgc gcgcgcaagt ccgggtcgtc
     9061 gacgccggtc gccgtggttc ggttgtcagc tggccgagag cgagccgccg ttcaacgctg
     9121 tgtcgtcgac gaaccccgcg aggtcagaca ttccctcgcg ggttatcggg ttcgtgtgtc
     9181 gaatccgttg gcgagtgcgt ggagggatag gtcgaggtag gtggtgaggt cggtgtcggc
     9241 tgtggtgagc cattggtcga aggcggcgcg gctggcggcg agtgtggtgc gtccgatggc
     9301 gagggggtag agggtgtcgg ggggctggtt gaggcgccgg gcggcgaaat cgctgacggc
     9361 ccgttcccag gcgtcgtagt ggggcccggc gctggtttgc agggcgggga cggtgctgat
     9421 gaggtgcatt cgggtgcgta gttcggggac gtcttcggcg cggtagtggt tgacgccgac
     9481 gacgacttcg cggatcgcgt ccatgagtgg tgtgtggggc gagacggcgt cgaacgcggt
     9541 gcggagtcgt tgtacttcgc cgtcgaattg gtgccagagg gcggcggatt tggagtcgaa
     9601 gtagcggaag aaggtgcgtc ggctgacgcc tgcgacggcg gcgatctcct cgacggtggt
     9661 gtcgtcgaaa ccgtgctcgc tgaacagtcg cagcgcggcg agttcgagtt cgcgcgcatt
     9721 ggtggccggc gggcgtcccc gtcgccgggc gtcggtgtcg cggtgaggcg tggtcattgt
     9781 cttctatccg tcgcaactat tgcttgtgtc accccgtgac gttatcgtac cgtctattcg
     9841 gcactgagtg ccgaatattg aaggtttcgt gtgaaggagc ggacatggct gacgattccc
     9901 gtgtggcagt aggcgaaaac gacgtggacg cgcccgatgt ggtgacgtcg gatttgctgg
     9961 tcgaggaggt ctcgatcgac ggtatgtgcg gtgtgtactg atgtctgatc cccaacacga
    10021 cccgatcttg gatcaagcgt gggtgctctc accgtcggta gcgctgcgcc cggagccctt
    10081 cggggcgttg gcgtatcact tcggcaaccg caaactcacg ttcctcaaac gtcgggagct
    10141 ggtcgtgctc gtcgagacac tcggcgagca tccagacgtt cggtcggctc tggtggctgc
    10201 gggagtcccc gaagtggagt acggggctta ttgttcggca ttgcacagtc tggctggtac
    10261 cgacatggtt cgaccgcgca cacgggaggt ggctgcatga ccgccgtgca ggaacgaccg
    10321 gtcggtggat cgttggtcga ccagttcgag ttggggctgg acgcgccgat ctgtttgacg
    10381 tgggagctga cgtatgcgtg caatctggag tgtgcgcatt gcctgtcgtc ctcgggcagg
    10441 cgggatccgc gtgagctgag caccgagcag tgtgaagcgg tgatcgacga gctgcagcgg
    10501 atgcaggtct tctatgtcaa catcggtggc ggcgaaccca cgatccggcc ggatttctgg
    10561 catctgctgg agtacgcggt agaccaccag gtcggtgtga agttctccac caatggcgtg
    10621 cggatcactc ctgaacgggc ccggttcctg gcctcgaccg actatgtcga cgtgcagatc
    10681 tcgttggatg gtgcgaccgc ggaggtcaac gactacgtgc gaggtcctgg ttcgtatgac
    10741 acggcactga ccgcgctgcg aaatctccag gaagcggggt tcgaggacgc gaagatctcg
    10801 gtggtgtgca ctcgcgagaa catcggccag ctcgacgagt tcaaagcact ggcggaccgg
    10861 ttcggtgcga cgctgcggtt gacccggttg cgtccttcgg ggcgtggggc ggatgtgtgg
    10921 gacgagctgc atccgcttcc cgggcagcag aaggtgctct atgactggtt gatcgcgcat
    10981 ggtgaggatg tgctgacggg ggactccttt ttccatctcg ccgccttcgg agagaagctg
    11041 ccaggcttga atctgtgcgg tgcgggccgt gtggtgtgtt tgatcgatcc ggtcggtgac
    11101 gtgtatgcgt gtccgttcgc gatccacgag aatttcttgg cgggcaacgt gttgtccgac
    11161 ggtggatttc agcgcgtgtg gcaggcctcc gagttgttca ccgagctgcg ttcaccgcag
    11221 accggtggcg cgtgcgcgaa atgctcgttc tatgacgcgt gtcgcggggg gtgtatggcg
    11281 gcgaagttct tcaccgggtt gccgctcgac gggccagacc ctgaatgcgt gcggggtctc
    11341 ggcgagagcg cgctggccgg ggagcggacg gttccgcctg cgagccggga ccattccaaa
    11401 gccgcgccga ctcgtaacca gccggtgatg ctcacgctgc tgtcccggcc gccggtgtcc
    11461 gcgtgcgcgg aaagcccgct cgccgactac gcgccgggcg ccccggagca gaaaggctgt
    11521 tgcgcgtgac actggagaat ccgtggaagc ggaacccgtg gttcgagtcg gtcgccgtgg
    11581 ccaaacgccg cgcccggaag cggttgcccg ccccggtcta cggtgcgttg gtggccgggt
    11641 ccgagcgggg ccagaccatc gatgacaatg aggcggcgtt ccgcgaggtc ggtttcgcac
    11701 cgcatgtcgc gggacagcga cccgagcggt cgatggccac gacggtcttg gggcaggacg
    11761 tttcgttgcc ggtgttgatc agcccgaccg gtgtccaggc ggtgcatccc gagggtgagg
    11821 tcgccgtggc acgtgcggcc gcggcgcgtg cgacggtgat ggggctgtcg aacttcgcct
    11881 ccaagtccgt cgaggaggtc accgccaccg gtgcaccgac cttttttcag atgtattgga
    11941 ccggtgaccg cgatgtcatg atccaacgga tgcggcgcgc ccacgcggct ggtgtgatcg
    12001 ggctgatcgc cactctggac tggtcgttct cgatgggccg tgattgggga agtcccgaga
    12061 ttccggagaa ggtcgatctc aagaccatgg ttcggatggc accgaaggtc gtgaccaaac
    12121 cgcggtggct ctacgaattc ggccgtaccg gccagatccc ggatctcacc gcgccgaatc
    12181 tggccccacc cggcggtgcc gcgccgacgt ttttcggggc gtatcacgag tggatgacca
    12241 ccccgccacc ctcatgggcc gacgtggcgt ggatgcgcga gcaatgggcc cagatcagcg
    12301 gcacaccgtt cgtactcaag ggtgtgtgcc gaatcgacga cgccctacgc gcccgcgacg
    12361 ctggtgtctc tggtctttcg gtctccaacc acggtggcaa caacctcgac gggacaccgg
    12421 gcgcgatccg gatggtcaag ccgatcgccg acgccgtcgg ttacgacgtc gaggtcgtga
    12481 ccgacggcgg aatccgccgc ggctccgatg tcgtcaaagc acttgctctc ggcgcgcggt
    12541 cggtgctgat cggccgcgcc tacctgtggg ggctggccgc caacggtcaa acaggagtgg
    12601 agaacgtcct cgacgtcttg cgtagtggca tcgactcggc gctgatggga ctgggcgtgg
    12661 cctcgatcga cgaactgaca ccggagcatc tactggtgcc accaggattc gaacgccggc
    12721 ttggtgcacc gacaccggag gtcgcaggcc gatgaccggt cacctcacgc acgccacctg
    12781 gcccgagatc gaccacgtcg agctcatcct ggtcccggtc gggtcgatcg agcaacacgg
    12841 tccacaccta cccttggata ccgacaccgc gatcgcgaca gccgtcgccc agggcgtagc
    12901 tgaaatcgtc gacggcgcct gggtcgcacc ggccatcgtc tacggttcca gcggcgaaca
    12961 ccaggccttc cccggcacta gctccatcgg gaccgaggca ctacaactac tgctgatcga
    13021 gctggtgcga tccatgcgga cctgggcccg tcgcgtactg ttcgtcaacg cccacggcgg
    13081 caacctccca gccctggacc gcgccatcgg ccagctcgtg gacgaagatc acgacgtgac
    13141 ctggaccccc tgcgcaatcg atgacagcga cctgcacgcc ggacgcaccg aaacctcgct
    13201 gatgctgcat ctacgccccc gatcggtgcg gctcgaccgc atggaacagg gcaacaccgg
    13261 ctccctgcaa caactcctac ccgcactcgt cagggaaggt gtgggcggcg tctcggccaa
    13321 tggagtgctg ggagacccag caggcgccac agccgaggaa ggcgaacaga ccctcgcgcg
    13381 aatggtgcaa accatcgcta cacgaaccac agcagcagta tgacccgagt agcgatcgtc
    13441 accggagccg cacgcggaat cggcgcggca accgtcgcgc gactcgcggc cgacggatac
    13501 caaatcatgg cagtggactc ttgcgaaggc ccaccactgg ccagccgcgc cgaactcgac
    13561 gccctcacag ccgcccacag tgacaacgta gtcgcacaca tcgccgatgt ccgagaccgc
    13621 tccgcgctcg ccaaagccgt cacccgcaca ctcgaacact ggcatcgact cgacgtcgtc
    13681 gtcgcctgcg ccgcggtgat gcgcggcgga gccccgctgt gggaaacccc cgacaccgac
    13741 ctggacctgc tgtgggaggt tgatgccaaa ggtgtctgga ataccgccgc caccaccgta
    13801 ccggccatgc tcaccggccc cgatccgtcc ggctgccgat tcgtggccat cgcgtccgct
    13861 gccggaaccc acggcatgtt ccaccttgcc gcctacaacg ccgccaaaca cgccgtggtc
    13921 ggcatcgtca aaggcctggc cgccgacctc gtcgcgaccg gagtcaccgc atgcgccgtc
    13981 tcacccggat ccaccaacac accaatgctg cagacaaccg ccgaccttta cagcgtcacc
    14041 atcgacgaac tgaccgacca ccagctgatc agacaaccta tcgacccagc cgaaatcgcc
    14101 gacaccatcg ctctctgcgc ctcaccggca ggacgtgtgc tcaacggcag tgtcgtacac
    14161 gccgacggcg gcttcgcatc atgaccacca cacccgcccg acttccagac ggctttgagg
    14221 tccggatccg agaggatgtg acacggctgg cgaacgggca cgtactggta ggtggcactc
    14281 ccttgcgcgc gctgcgcctc accgacgcgg ccacagcact gatcgagcac gaccggatcc
    14341 gggtagtcga cccagccagt gccgcactcg ctcgacgtct actcgacgcc aacatcgccg
    14401 accccgtcct cagtgcggca gtgccgaacc atgtgctgac cgtcatcatc ccggtgcgag
    14461 accgccccga acagttggac cgggccctgt cagcccttta tccactcccg gtggtcgttg
    14521 tcgacgacgc ctccaccgac ccagaaaccg tcgcgcagac agccgcacgc cacgacgcgc
    14581 acctgatcac gcttcagctc aaccagggcc cagccggtgc acgcaacgcc gggctcgctc
    14641 acgtcacaac cccctacgtc gcgttcgtcg actccgacgt cgaaatcacc gcggacgccc
    14701 tcctacgcct cacacgacac ttcaccgacc cctgcgtagc catggtgggc ccccgaatca
    14761 tcggtatcgc ccgcacgacg cggccgcggt ggcacgaacg atacgacgaa tccgcctcct
    14821 ccctcgacct cggcgaccgc ccctgctccg tacaaccagg cgccaccgtc gcctggatcc
    14881 ccagcgcctg cctactcgcc cgcatcagcc aactcggcga cggcttcgac cccgacctac
    14941 gcatcggcga agacgtcgac ctcgtatggc gactcaccac cagcggccac accatccgct
    15001 acgaccccac catcaccgcc caacacgaca cacgacccac cctgaccgga tggctcgaac
    15061 gcaaattcgc ctacggcacc ggcggcgcca cactcgccca acgccacggc acccacaccg
    15121 ccgtcgcacg actctcaccc gccatggcac tcgccgccac agccctgctc acacgccacc
    15181 gttactcgat ccccatcgcg gtcgtctgcc tcgcctacag caccggatct ctcgcccgca
    15241 gcctgcccga cgctgtacgc ggcaccggac tcgccaaccg gctcgcgatc cgcggattgg
    15301 gctggtcact acgccaggaa tcggcactac tactacgaca ctggtggccc gcaacactcc
    15361 tcgccgcgct cacgaaccgc accgcacgcc gcgccctcac aacagcggcc atcatcgacc
    15421 tcatcacggc aaaacccggc agcaaccaga acccactcaa cacattcctc ggacgccgca
    15481 tcgacgacct cgcctacggc gccggcctct ggtggggagc aatcaacatt cgctccccca
    15541 aaacactcgc catacggtgg atacgcgtgc gccagaaacc aaacctgcac gctggcctgt
    15601 ccgcgagggg aaactgtcct tctcgagcag tttccgctca tggcgtgtcc taccggttgt
    15661 gaatcgtttg ccatcacgtg gtccctaccc aaaccgctcc cacgtttcag aatcgatgag
    15721 ctttcccttg aatcgtgaag acaagatcaa tcttagggca tgcgctatag ggggtgggca
    15781 tgtcagagtc acaacggaag ttcgatccgg agttccggga cggtgcggtg cacttggttc
    15841 tggacacggg caaatcggtc gccgaggttg cccgtgacct gggaatcaac tcagcttaac
    15901 tgggtaactg ggtaactggg taacaaagga tcgtgagcag cgcggcgcgg tcaatgggat
    15961 acccgaggat ccggctgctg aggtgaaacg tttcgggctg agctggcgtc ggtgcgggcg
    16021 gagcgtgatc tgctaatagg tctggacagc ctgctcgtcg agcggcggcc cgccacgacc
    16081 actcatccca aggctcgggt ttgccacccg cggacaatgg aacagttcgg cgtgtggggc
    16141 atcgagaacc gagtgcgccg tgcgggcctg ccccaggagt cggacgtggc gtgctggtgc
    16201 gggagcctga acgggccgtt ggtggcctac accgaccccg cccccaccct gcaccgcggt
    16261 cgatcgtgcc ccaggaggcg gtggaagagg cgctggacga tgcgttgtcc acccggccac
    16321 gggcacgggt gcgccggctg accgagctcg tgtcgttcac ccaggacgcc gatggcgtga
    16381 ccgcacgggt acggccgagg gagggcggcg cggagttcga cgtgcgcgct cggtacctcg
    16441 tcgggtgcga cggggcgaac agcccggtgc gtgacatcgc ggggatcgcg atggatgccc
    16501 cggagacgtt ggagctcatg gccaaccgct actaccgcgc cggcctcggg cacctgccgc
    16561 acgtgtgcag cgccatcggg ttcttcgtcc gaccgagccg acccgtcccc acgtcaatgt
    16621 actggccacc ggcccggacg gtgaccgttg gctggccgtg cagaagctcc gcgacggcga
    16681 gcagcagctg gtcgagctgg tccgcgagca gtgggaacta cccgacctga aggtcgagcg
    16741 catcaacgtt atgaactggc ggatgagcgc ccgagtcgca cagcggttcc gcgcgggcag
    16801 ggtgttcctg gccggcgacg ccgcgcaccg gttccccact tcaggcggta acgggctcaa
    16861 ctccggggtc caggacgtgc acaacctcgc gtggaagctc gcgctggtcc tgtccggacc
    16921 agccgatgac gcgctgctgg acacctacga gtccgagcgc cgcccggtcg cacagtccaa
    16981 cacggattta gccgtgcgca accagacgcg gatagacgag atggacgagg cgttccggcg
    17041 ccgcgaagag cagccacagc gctggcgcga tctgctcgtc gaccagaaca agcagttgca
    17101 cagcgatggc cacactctgg gctacgtcta cggtcgggga accatcgtcg acgacggctc
    17161 cccgataccg ccctacggct cgcagcatta ctggccgacc gaccggccca gggcccggtt
    17221 cccgcacttc tggctggacg tcggcaaggc ggagtcgacc atcgactggt tcgacaccag
    17281 gttcgtgctc gtgtgcggcc cggacgcgga aggctgggag cgggcgggga aggacctggt
    17341 cgcgtcggtc ctcgtaccgt tccaggtcaa acgattgccg cacctgctcg gaccgctgtc
    17401 gatccgccat acgggcgctg ctctcgtgcg cccggacggg cacctcgcct ggcgtgcccg
    17461 aggggcgggg gaaaacggcg aactcgcggt cgcgctcggc cgggtgctcg cgggcggcac
    17521 tctcgcccgt ccgcccgcgt ccatggcggg ctcatgactg tcgaggagca ccggaacacg
    17581 ctcagctacg ccaatccgcc gggcgtcggt gagccgttca gctcgtattc ccatgtggcg
    17641 cgtacgaaac gggctcaacg ccctcgcccc tggcctctac ccggtgcccg tgcgggccac
    17701 cggggtcggc tgggctgacc ttcggccgca tcggcgccct gaccgcaccg gcgctggccg
    17761 gtgtgctgct cgaccactcc tgggcacccc gctcactgtt cggactgctc gtcgtcccgt
    17821 tggtcgtggt ggccggcgcg gtcatcgtga tcaccctgcc acgccgacgg ctacgcaagg
    17881 tcgtgcccac cgaggtgccc gctcaactgc cctgacccga tcggcactct gcgaggagaa
    17941 gtacatgaag gccgtgcgtc tgcgcgatta ccacaagcaa cccaccgtcg aggaggtgcc
    18001 cgaaccggtg ctgtccggcc cgctggacgt catcgtgcgg atcgggggag ccggggtgtg
    18061 ccggaccgac ctgcacatca ccgaggggca atgggcccag gcaatgggcc caggcaatgg
    18121 gcccaggcaa tgggcccgcg gctgccctac accttgggac acgagaacgc gggctgggtg
    18181 cacgcggtcg gcgccagcgt caccaacgtc gaggtcggcg acaccgtgat cctgcacccg
    18241 caaccgtcct acggactgtg cccggcatgc cgggctggcc gcgacatggc ttgtgcggca
    18301 agcgctttcc ccggtgtgtc cgatcacgac ggtggcatgg ccgagtacct gcgcacgagt
    18361 tcgcgggcgt gtgtccgcct cgacccggcc accgaccccg ctgacgtagc cgcgctggcg
    18421 gacgcggggc tcaccgccta ccacgcggtg cgtaaggcgg ttgcactgct gccaccgggc
    18481 agcgtcgcac tcatgcaggg cgccggggga ttgggacatc ggcattcagg tcctggctgc
    18541 gctgaccggc acgaggatcg tcgtggtcga ccgcgacgcg ggcgcgctcg cgcttgccac
    18601 cgaactcggt gctgacgtga ctgtccgggc cgacggtaac cagacggccg cggtactgga
    18661 cctgaccggc gggcgcggcg cggacgtcgt gttcgacttc gtcgccgaac agggtgcgga
    18721 gaatgacgca ggggccatca ccgcggccgg tggctcgctg ttcgtgatcg ggtacggcgg
    18781 cgaactgcgg atccccacca tggcattggt ggggcaggag aagaacgtcg tcggcaacat
    18841 ggtcggcacc tactgcgacc tggtggagct gatggtgctc gccgaaaccg gcaaggtgac
    18901 actgcgcact cggcgctacc cactggacgc ggccgccgaa gcgctcgacg atctcaccct
    18961 gaaccgggtt cgaggccgcg cgatcctggt cccgtccgca tcaactgcgt gacccgctcg
    19021 tcatccacga caacgcgcat gtgccacgta ccggcaggat tgcctcgatc agcggcatga
    19081 gttgggtgac atcctgccgg ttacgccgcc cccgaccagg cgatcaacct caccaagcag
    19141 cctggccagc agcagctcgt gcgggcgtga ctacacgcca gcctcggtcc agtcccgtaa
    19201 ccaccgccag cagatcatgc ctgagccatt ccctatctcc tggcgcagga attgccacgg
    19261 gatggccgtg tacaacctct gtagagctgg gctgtcgcgc ggacacggct gtcttgggcg
    19321 gtggtcgttg gtcgctctgg ccctgcgcat cgcggacgcc tcatcgacgg ttcgtgccgc
    19381 ccggcagggt cccttggcgg gcatggattt catgaccggg ttttggggcg gacgtgagga
    19441 tggtgtgttg cttgttccga gatgagaggg agcgggacgg ccggcgggag cgtggtcagg
    19501 ttgggcctgg tttggaagga ctgaatcatg agggcggcga agcgccgtga cgtcgccgcc
    19561 ctcagttggg gtgtcgcggc ttggatgccc tcgttggtca tcagtgcgag gacgaggtcc
    19621 tccagtacaa agtccgcccg aagctcgccg gtatccttgg cgctccggat gaggtcgagc
    19681 agctggcgca gtgttcggtc gcgctcggct acgaggtcga ctgtcccggg gagcctggag
    19741 gcggagccgc gatcgcgtgc atgtacctcc agaagcttct cgatcaccag accgaacccg
    19801 cgccacgggt cgtcgtgtgc caggccgtcc tccacgatgc tcgcgcatga gggcctctgg
    19861 tcggcgaagg ccgcagccag caggacgtcc ttggtcggga agtgccggta caccgtcgcg
    19921 acgccgacct gggcgcatcg ggcgatctcc cggatcggta catcgatgcc ctcggctgcg
    19981 aacacggcgc gggcgacagc caggatgcgc tcccggttgt cgcgtgcatc cgatcggaga
    20041 ggggttctcg gttgggccgt catcactctc atattagcga aacgggcggc gtgccccgtt
    20101 atgttgagga ccatgcgagt agtgcaattc aatgagtacg ggccacccac cgttatgcag
    20161 gtcgccacgg tcgaggagcc ccataccggg ccgggccaga tccgtatcgg ggtgcgggcc
    20221 tcaggactca cgaccgggga ggtacgcgtg cgttccggag cgctgcgggc gatggtaccc
    20281 gtatcgttgc cctaccggac ggggttcgac gcggcgggtg tcgtggacga ggtcggtgag
    20341 ggtgtcgcag gcgtgagcat cggtgacgag gtattcggca tgaccgcttc ggccacccga
    20401 ggcgccaacg ccgacttcgc ggtgctggtg gcctgggcgc cccggccggc cgtgtggacg
    20461 tgggaggaag cgggcggtgc cgcgggcagc gtcgagactg cgacccgcgt cctcgaccgg
    20521 ctggccctcg gagccgaaca gacagtgctg gtgcagggcg cggccggggc gaccggctcg
    20581 gtcgtcgtgc aattcgccct cgcccgtggc gccaccgtca tcggcacggc ctcagagcac
    20641 aatcgtcagt tcctgcagtc cctcggcgtg gtgccgacga cgtatggacc cggtcttgtc
    20701 gagcgggtcc gcgccttggc gccgagcggg gttgatgcgg tcatcgactg cgccggtggt
    20761 gccctgcccg acctggttac catcgtcggc gatgccgagc gtgtggtgac gatcgcggac
    20821 ctggacgccg cggcgtacgg cgtccacctg tcacacggcg cccccaatga cgcgcccact
    20881 gacgggacag gcgcaaccac tgtgccccac gccgatccac tcgctctgca cggcctcacg
    20941 accgcggtca cgctcgcaga taagggcttg ctgcgcgtgc ctgtcgcggc ggcatttccg
    21001 ctcgatcagg ttgccgaggc gcacgcactg agtgaagggc ggcatgcgcc aggacgcatc
    21061 atcctgacga acacagctcg tcgttgacct cccacggcct ccacggtgga tgccgtagcc
    21121 agtggccgcc tgcacggccg gtctgccatt ccttaaaacg tagttctctc ctgccggatt
    21181 tcgcgctcct gcttcccatc gcgaccggtc tggcacatcg gcggacatca accatgatcg
    21241 ccggatacac ggaaaccgtc gagcggcaca aggacgccgg actgaccgtt cccgacggag
    21301 tcgactacca gaggccgcga ccagctttct cacggtcgct tcgacttcgg cgtcggaaag
    21361 ggctaccggc gaacgagttc gcaaggttct ggatggtcga cgcagacgcc gcctcgcgtg
    21421 acgaggagac tcgtgtgttc tggatgcgcg catggtcgga cacggacgct tcacccacgg
    21481 cggtgcttct tggaagttct atgacgtcat gatcgacccg actgtccaac ccgtccatcc
    21541 ggatcggtgc gacgagcgcg ccgtgcgtga ccaaggcggt cgggacaggt tccaactgtt
    21601 actcgaccag atcgcagacc cgacatcgtg ggccgacgcc tcgtgcggga gcgcgcgaag
    21661 aagttcgacg gaccgtgcgc tcagccggat ccgagatgga accaccgtgc gacggtcggt
    21721 gacaagactc tgggcttcga gatggtgggt tccggtaggt cagtcgttga tggcggcgat
    21781 gcgctcactg atcgcccggg ctgcgtcgag gaccagttcg atgaacttcg cctcggcgct
    21841 ggtgtccacg cgcgtggcca gggcggccac gctcacggcc gcgacgacgt cgtccgcgga
    21901 gttgcggatg ggcgctgcga tcccgagtac gtcgggatcc agttccgctc tggttatcga
    21961 gtagccgtcc gcgcggatcg tgacgagccg tttcatcagg tcgtcgacgt cggtcagcgt
    22021 ggcgggggtg aattgccgga atggggccgc ggattccagg acggcgcgcg cttgctcggg
    22081 cgggctccag gccagcagtg ccagtgcgga ggctccggcg ttgacggcga gggtgctgcc
    22141 gggttcgtag gagatcctgg ccgcgcgcgt cctggattcg gcgcgctcga cgcacaccac
    22201 gagatcgccg acgcggcggg tcagcaggat ggtctcgccg gtggcttcgc agagcccggt
    22261 catgattggc atcgcggctt cggagagccc gtagctgcgc cgggcgaccc gggcgatttc
    22321 caggatccgc agtcccagtc ggaatcctcc ctcgggtgcc tcttccagga agcgggtcgc
    22381 gaccaggctt tgcagatagc ggtacgcggt ggagcgcgcg accccgagcc ggtcggcgac
    22441 cgcggctccg gacagcaccg gttcggtgtc ggtgaacatg ctcagaatgt ccagtgcccg
    22501 atcggcggtc gaattgcggg cgcggtacgt cccagacact tttcctgaca tgcgggacag
    22561 cctagggcac tcacgggtga accgagcgca caccaggtca ccgccctgct attgttgttc
    22621 gtattgcagg agttatatcc tgctaaacag gacatacaag gtgggtgttg acgtggatgt
    22681 gaccgaacgg gactggcgct gggggcgggt acgcgagcag atgcgggcgc gcgagatcga
    22741 cttgctgatc gcgtt
//
