LOCUS       NZ_KB905395            25308 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Sciscionella marina DSM 45152 A37UDRAFT_scaffold_22.23, whole genome
            shotgun sequence.
ACCESSION   NZ_KB905395
VERSION     NZ_KB905395.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Sciscionella marina DSM 45152
  ORGANISM  Sciscionella marina DSM 45152
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Sciscionella.
REFERENCE   1  (bases 1 to 84271)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Sciscionella marina DSM 45152
            collection_date                   :: SEP 2006
            lat_lon                           :: Missing
            depth                             :: 516 m
            alt_elev                          :: Missing
            country                           :: China
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 45152
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: 19196758
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Sand; Sediment; Marine; Aquatic
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11892
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site :: Marine sand sediment at a depth of about 500 m,
            the northern South China Sea
            Cell Shape                        :: Rod-shaped
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28 C
            pH                                :: 7
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000379465.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 01:37:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,209
            CDSs (total)                      :: 8,146
            Genes (coding)                    :: 7,961
            CDSs (with protein)               :: 7,961
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 1 of 185
            Pseudo Genes (frameshifted)       :: 52 of 185
            Pseudo Genes (incomplete)         :: 155 of 185
            Pseudo Genes (internal stop)      :: 15 of 185
            Pseudo Genes (multiple problems)  :: 34 of 185
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:59:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3361
            Orig. end                         :: 28669
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905395.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405877
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25308
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25308
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25308
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15308](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15308
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(255..269)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(632..645)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.8"
                     /tool="antismash"
     gene            complement(1258..1722)
                     /locus_tag="A37U_RS0121845"
     CDS             complement(1258..1722)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498812.1"
                     /transl_table=11
                     /translation="MIATSDPDETCRAIRRAGGVRSWREPDRHTSHTCAYRLDQADIQL
                     RIHDHHSTVHISAASADQVRAAALALGHNQIPHIERWQPTREPMTPQPHSTSTDAREME
                     AELEATQRSVQRARATLHTSGALNTSACRALLERLRDTAQTVLTYDHTRP"
     gene            complement(1764..1889)
                     /locus_tag="A37U_RS54460"
     CDS             complement(1764..1889)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS54460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_276142042.1"
                     /transl_table=11
                     /translation="MPRPPVRGTFAGPTAALKFSLVALTVVAMLAAVTTIGLVLA"
     gene            2310..3194
                     /locus_tag="A37U_RS0121855"
     CDS             2310..3194
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018687084.1"
                     /locus_tag="A37U_RS0121855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_026197482.1"
                     /transl_table=11
                     /translation="MPAGNPTTKKRLLGREIAYMIDKTGISQTQAAKILETSQSRIAGL
                     LNGTGTITPGDLTLLATGLGFTDPDYLEVLRELRRDYHKRGFWNTGHRRAYSEDIRLRI
                     DLEQHADKFSALEVEIVFGLFQCESYVRALHADEPNINDVSLEDMIQARLARQQILDTS
                     NPPSMHVVLSESCLRRVWGGPEVMREQIDHLIKLSNRPNIFLQVMPFDQPAGRRSPIGC
                     PFVVLRVPTPGRAGPLEMAYVEGQGEIRYVDDEDSVRVYEDAWARLSNAALRYDETRSF
                     LTEVDREFANRSA"
     gene            3224..3601
                     /locus_tag="A37U_RS0121860"
     CDS             3224..3601
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.4"
                     /locus_tag="A37U_RS0121860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_020498815.1"
                     /transl_table=11
                     /translation="MSTTRPRFLETDFRKATRSNPNKDCVRVARHSDRVEIRDDKTVFG
                     SEQDHRLLLTAAEFDAYQAAIRHDAPTVEHLALTLQPDGTYRMSTATRPEVFLVFTAAE
                     IAAFHHGVCHHEFDHDTLAAA"
     gene            complement(3625..4095)
                     /locus_tag="A37U_RS0121865"
     CDS             complement(3625..4095)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157182957.1"
                     /transl_table=11
                     /translation="MSGVRIFRGGHRRTSGPRAVALAYGRANSVRPLDFCTFELIDSAD
                     AGLPTEDEPLRLTKWMKLDHFPDNDTLTVQTTGLGRFGLPELHCPGILRDGLRDWAVVL
                     NELALRCCEALFGLSRDTKTVELLAEHDIHGANLALEPGPDGMLHVQGTRPV"
     misc_feature    4133..4148
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.98"
                     /tool="antismash"
     gene            complement(4428..5627)
                     /locus_tag="A37U_RS0121870"
     CDS             complement(4428..5627)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230488.1"
                     /locus_tag="A37U_RS0121870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_020498817.1"
                     /transl_table=11
                     /translation="MTDLAANLARLRKARDLSQEELAEAAEVGTDTVARIEQGKRRTAR
                     PTTIDRLATALGVTPQALGGSAPSEGQNERSIEDLRAAITASEDIPGMRDLADDDRELL
                     SLPQLDIAAHSAWAAYVEGQHDRLIDTLPVLLGDARRFVHASPDDQRSAGQRVLSTAYR
                     LAAGTAGRFGCTDLAWIAAHEGLDHARHCDQPELEAAIATRYLVWTLVRQHRYAEAERV
                     ATIAAERIEPRMLDRDTQRAGVFGNLLFNAATAATLAGAHPRAGDLLAEARAAATRAEG
                     DWVSEAAIFGPRVAAFQTIEHTIRAGNPDEAVRLNAAIPNGGVPAFWEAGHRLLMASAE
                     LALKRRDQALTYLAEAARLAPDWASRQPLGCSTMQALIDHAPRRRTHTFARLANLYRLV
                     "
     gene            complement(5624..6109)
                     /locus_tag="A37U_RS0121875"
     CDS             complement(5624..6109)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230489.1"
                     /locus_tag="A37U_RS0121875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_020498818.1"
                     /transl_table=11
                     /translation="MDLLPFDEYVASLNRKRNSAAAVFYDADGRVLLVEPTYKPHLDLP
                     GGAVEADEPPWQTVAREVYEELGIRRTFAAPVVIDYTPTNERLPEGFAWVFDGGLITES
                     EVKALELTDPEIHSVTLHHLDEVADQTKPDLIRRIAVALEVVNTGGFALCENGERVR"
     gene            7155..7622
                     /locus_tag="A37U_RS0121885"
     CDS             7155..7622
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_026197483.1"
                     /transl_table=11
                     /translation="MPRPLSWMELAYSFLQQEGKWRAVAFRALRGEISADRLLGYAKEL
                     RETAAEVEESVRQRVSSETALDSAPAGEGALLRPEVVDSLNSIHVLSGSGAVAMLENTR
                     TAADLHELLKRTAFSLAEAAKLAMDNAQDLDRSRESAPGDPHPPGGQHDQR"
     gene            7803..8336
                     /locus_tag="A37U_RS0121890"
     CDS             7803..8336
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="A37U_RS0121890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_020498821.1"
                     /transl_table=11
                     /translation="MADHGWRVRAEIVIHDRDDHRDKVPILLVQGPQGWALPGGFVENT
                     SVRAALDEHVREQTGLDFSGDLQEVVPVGVFEVDTGYGWVLVFQLEAVAEAAKAARGRW
                     FDLGDDLPSPTDPWSQATLPRSSWVVPHDGLPNEVGWPLDQIPHGGAPTEPHDNTPPSQ
                     IHDSEAQGKGHDSR"
     gene            8333..9628
                     /gene="fxlM"
                     /locus_tag="A37U_RS0121895"
     CDS             8333..9628
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155777.1"
                     /locus_tag="A37U_RS0121895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_020498822.1"
                     /sec_met_domain="PCMT (E-value: 2.4e-42, bitscore: 137.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSKNNRPNQRIGRADQDRIEDARQAMMHELWHMRALRTVRVSDV
                     FMRLGREEFAPEVAVEEVYAAANAVVTKRDEHGRAVSSISAPQIQAFQLEQADVRPGMR
                     VLEIGSGGVNAAMLAELVGDTGEVISIDIDPEITAQARRLLDANGYKQVRVETADAENG
                     LPESAPFDRILTTVGCWDLPPAWITQLTDGGRIVVPLRMRGLTRSLALDRSGDRFVARS
                     AETCGFVEVQGAGAHTERMLLLYGDQVALRFDDNNGPDNPHTLGGVLGTERATAWSGVT
                     VGGMESFEDLLLWLASTLPGFCSFAVADDYNPDERAPHLVDAGQRWFPTAFLHSDQASF
                     AYLVSARRDEGVFELGAHGFGPAAEDAVATMAAQIRNWDHDHRGGPGPQISVWLYNTPD
                     KAMIPAGDPEGSVAVFDKHHCRVMVSWPTPAG"
     gene            10001..13027
                     /locus_tag="A37U_RS0121900"
     CDS             10001..13027
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="A37U_RS0121900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_020498824.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.6e-176,
                     bitscore: 578.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.2e-19,
                     bitscore: 61.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPRLYRHSGFVMVRASTGPGGLVLPDLDLHTSENAATTGKTWL
                     EWLWNRDDVRQVVEHASPAVANKIGEALSGEALSRRQWRRLLTTTCSYVLRWQRRATPF
                     GYFAGINTATIGPATEVILGDEHQIHRRPDPRHLDELLRELEANPAVVAQLSVMVNNAG
                     ITRGDQFAVPKRLHNTTTAPGQAVTALSAVEVAVRRTPAVDAVLDRAASPIPAEKLVTE
                     LENQFPTATAEQITGLLGGLIEAGVLLTDLRPASTVHAPHTWIHDQLNKTDRTTNLTAR
                     RAVTETRTRLRALTTPTPERSPSPREVGPGSGVDLALDAQVSLPEPVVHEAEMAASVLA
                     RVSAHPFGAPAWREFHQRFRERYGAGSLVPVRELVSDSGLGYPAGFLGAAREPAPRLLS
                     ERDAVLGDWIQQALIDGDTEIALSESMINRLTVGDPTHHIRPERVELSFTVHANTPRDV
                     DRGRFELWVTGAPPASSSMCGRFTDLLSAAEQDRLAATYTTEIQDAVLRAQLSFPPRQV
                     RNDTIARAPHLLPWLLPIGEHTPDHEPYLSLDDLGVTADAARFYLVHRPSEKLVNPYVL
                     HALEQPMQTPALVRFLAELPIARSSVYGPFDFGAFRTARFLPRIRYGRSILAPARWLLS
                     AADLPGPTAPTDGWDTAFAAWRTRWHVPARVAVIDGDQRLPLNVEDRTERSLLRALAHR
                     GGKLELCETSPPAEDSWTGSPVEFVVPLTVHTTPTPHWTGAASEPVFPGDSGLLTARLE
                     IHPQRGDAILSSYLPQLTRELPDGARWWFRRYHDTTRPDSAHELHLTIRSTGHGDHGAL
                     AALVSRWAQELRAAGLVSRLVFDTTWPTAGRYGAAPDVCEPLFAADSAAALTEIGFASR
                     HNMPIEVVAAVSMLDLAAGVLDDPVRAWSWCRDELPRHEGHCPRDHQQQARELQRALAA
                     TPVDTARAAMSARWAERRVALDDYRFRVDRDPVRVVRALLHEHFVRAVAVDPGREQNTN
                     RLVRALALQQLSRTPQGTP"
     aSDomain        10469..10765
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_A37U_RS0121900_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="1.60E-19"
                     /identifier="RREFam001.1"
                     /label="A37U_RS0121900"
                     /locus_tag="A37U_RS0121900"
                     /protein_end="255"
                     /protein_start="156"
                     /score="61.3"
                     /tool="antismash"
                     /translation="VMVNNAGITRGDQFAVPKRLHNTTTAPGQAVTALSAVEVAVRRTP
                     AVDAVLDRAASPIPAEKLVTELENQFPTATAEQITGLLGGLIEAGVLLTDLRPA"
     gene            13087..14298
                     /locus_tag="A37U_RS0121905"
     CDS             13087..14298
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="A37U_RS0121905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_020498825.1"
                     /sec_met_domain="LANC_like (E-value: 1.1e-49, bitscore:
                     161.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGIDGSREVVLARLTQQLAQPVNPPGQRQSLASGVLGAALWHLE
                     RAHYGIPAARERAHTCISTALADPISNAEVAGLFAGLPAVAFVLHTAEAVIPEYQPVIA
                     EFDTHLIRLAHRRVDTAQARIRSGKPATFGEYDLLGGLTGIGALLLRHHPGNDALHRVL
                     TYLVTLTQPLRRDGENLPGWWVGHAPDPLLPTPGGHANLGLAHGITGPLALLSLAHRRG
                     IHIDGHREAIERICAHLDRWQHPSDTGTWWPYWITHHTYKRGHHDQTHPERPSWCYGTP
                     GIARAQQLAAIATGDTRRQQRAETALDACLSDPDQLDLITSTGLCHGWAGLYHTTVRAA
                     ADAHTPALAAHLPRLATRLARHTAEAPPAEYGFLDGATGTALALHTTPINTPLSDWDQC
                     LLTI"
     gene            14280..15308
                     /locus_tag="A37U_RS44605"
     CDS             14280..15308
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="A37U_RS44605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_020498826.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.4e-37, bitscore:
                     120.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADNLNPNHTVCPEALHAAVHHALTGAALPLVAAEHGLNHDELH
                     DAVEVFLRAGASALYEYSSDPDWYSAHLEFSDWDQAERIALLTFEPLLNIWTGSGLLER
                     WWFIRKAPAWRLRLQPGPNAGDILVPTANDLFDKLVTSHTLADWRPVRYEPEAHAFGGP
                     TGIRLAHQLFHADSVHLFAYLAHDQPPIGIRELSILLCTVLFRAADQEGFETGDIWHRV
                     TYLRPSTGHDSSTSTGHHTELTEQLRTLLRYDTHPGGPLFGDDGPLHELQPWAQAFHDC
                     GHALAAVNHTNQLHRGLRNVLAHHVIFHWNRCGFDQPTQHALAHAAATTAFELRPEPDP
                     PP"
     gene            15383..15958
                     /locus_tag="A37U_RS0121915"
     CDS             15383..15958
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498827.1"
                     /transl_table=11
                     /translation="MMLTAHVLIAWRPRRPGDEQPEPQAAYPYLTAARPDGGIDESTEA
                     WQEATRHQQRLRAANTDTTFAAITVSSSVADPSGVATALVLNRARSVRRHDAVPNLTLT
                     PATPEQTSQISALEAAEYLRTGHGLVLDDSIDGCNAVLLALARRALCGDPCAQVALAEF
                     CTEHDALPWHQRPFDLASPARADTESRR"
     gene            15992..16252
                     /locus_tag="A37U_RS0121920"
     CDS             15992..16252
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498828.1"
                     /transl_table=11
                     /translation="MQLLVTMSMAAALLVSGSGAVIGALALRVGRARHQQRRPRIPDSR
                     AQMRVRETRCREGTPVESTMPLPLIADEPPDHHPVRPDPTS"
     gene            16298..17320
                     /locus_tag="A37U_RS0121925"
     CDS             16298..17320
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157182958.1"
                     /transl_table=11
                     /translation="MTGDRKTEAAAPITTLLDSSYGYDRETLVLRAQQQWNSQFGTQRP
                     WEQATDNEQQQWLHLVAGQILQCFHEAPDPADSVIPIDHSAPFSPPYPAGADELAHWHR
                     RAAQSIDWYRYRAHTDGLHIAGDTDQPQHLVLQPAWDSPDLPDEHVRGELDERISFLRM
                     LDHRRPRPSGVDELAELITAQAARVQHTETGLRSGVDNYRRRRHSEAQSWLSLLRDRQH
                     NRATPHLWRTGGPALVRALETHAPHLLLTETDRVPEALIVIAVHDHAPDKPFDLFDEIQ
                     AYAGIWDEHAIENTLHSAIAGGLVCLQPELGALQLTETGQRRYQNLLDTIRNTPPNPDG
                     "
     gene            17382..18182
                     /locus_tag="A37U_RS44610"
     CDS             17382..18182
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019322.4"
                     /locus_tag="A37U_RS44610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_020498830.1"
                     /transl_table=11
                     /translation="MTDSTTTAPAHPYQRLADELREQILKGHFEPGQVLPNGRELAAEH
                     GLSRAPVLRAMQLLRDEGLVHLEHGCPARVKLQPEIHRLARTAIPTPCQDPGTRNPLGE
                     SEQPESHVSPTVRIRFQLAGERFAEILGIDPDAEITVREHLQRPGKHAILHTTSRLPRD
                     LTQNTPIERTNSTPDQLYPQLEAAGHTITHYTEEVGARMPTPDELARLGTTNGIPVLTT
                     TRITHSTTRILEVNESTMFADRFRLTYTWPNHTNHQTTEPRPHI"
     gene            complement(19387..19995)
                     /locus_tag="A37U_RS0121940"
     CDS             complement(19387..19995)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498832.1"
                     /transl_table=11
                     /translation="MNRQARTAHTARWWQQAARAHAQLSAGIRPDTTWSSFTMDPGEVA
                     FGNLMIQDIDYSRLIVPNPVHYHQPGRLVVGSPQFVTGALLGSMAAGMLGRRRARKMSQ
                     PYWEDPVGAMVTITDRRLYCDAWGTALRFDYAATTGVDPNLGCSQVTLSFANTTPLRLT
                     GPAAVLVAVFASHHVHGPAAASMPQLAALRQVPVAVGVR"
     misc_feature    20406..20424
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.16"
                     /tool="antismash"
     misc_feature    complement(20409..20424)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.9"
                     /tool="antismash"
     misc_feature    20436..20450
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.56"
                     /tool="antismash"
     misc_feature    20564..20580
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.58"
                     /tool="antismash"
     misc_feature    complement(20599..20614)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    20848..20863
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.03"
                     /tool="antismash"
     gene            21178..21726
                     /locus_tag="A37U_RS0121950"
     CDS             21178..21726
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498834.1"
                     /transl_table=11
                     /translation="MNCRPDRAIDVFRRRTDAATAPQRIDHGGTASLGVVDIPTTRSTA
                     SWVSGSLLARATALANENIKTLKRRLAEPVTRPQTCPVRSSHTRHTWKNTFGITEGRAF
                     RSIERRGHLGTGISGEYIGAAITRAGERAGLATEARRAGHDPVAIGRQGGWSDGSAALL
                     GDMQIADRWDDNALEDIGL"
     gene            21817..22206
                     /locus_tag="A37U_RS0121955"
     CDS             21817..22206
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0121955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157182960.1"
                     /transl_table=11
                     /translation="MPITPRIDEMLTETVRLIVDAEKCDRDQMTFRPFEIYRGNTQIGS
                     GDYTTCHTCRLVELGEIGFIEPEQRRGLGTRTLLRLRALLPGYHWILTPTKAGSAPFWH
                     RMQRAYPDEYYDGRDPRGRRCRHII"
     misc_feature    22684..22704
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    23051..23065
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(23059..23074)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            23112..23396
                     /locus_tag="A37U_RS51755"
     CDS             23112..23396
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS51755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157182961.1"
                     /transl_table=11
                     /translation="MCKFSEQRQSNYTGPGDRITVTPFHEPHDKLEKMREIVRRWPIGE
                     PDSDGWQRYTELNSCHRAGKGYVAILLTVQIEHRWPVHAVRYGVSLFTR"
     misc_feature    complement(23492..23506)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.26"
                     /tool="antismash"
     misc_feature    23521..23534
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.41"
                     /tool="antismash"
     gene            23678..24652
                     /locus_tag="A37U_RS49935"
     CDS             23678..24652
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025200.4"
                     /locus_tag="A37U_RS49935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4192 domain-containing protein"
                     /protein_id="WP_083933728.1"
                     /transl_table=11
                     /translation="MTSSSVYRLLLSTPGEMLAALPLLLDHTPADSFVFIGLDAQRGLV
                     GAARCDTDASQAREAVRGALGTLMREGARAILVFVIHPLREDGELPYRDTVGETAEDVR
                     AMGMQVVGAFWTPRVQHRAQWRNYFDPTDTGLVADPYAARFTGLSETPTTLSATRDELA
                     ASYGHAVGEPVLRVRKQRIERTETDPALLREAFGRAVGSASKGQWSPGEVELVALAQAL
                     ASKPIRDAAIRYLLDERAGAAELVLTYLVRHLPAPYRCSPALLFMMLEASQRSGPRASI
                     LFEIARESDPENSLVQIFQQMPLNSFPPQVISKMLSKLTKKEP"
     misc_feature    complement(24968..24981)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.25"
                     /tool="antismash"
ORIGIN
        1 agacggtcgc gcgttgcact gaggctgggc tatcgccgag ctcgacagcg accgccaggt
       61 catgaatccg caatgacgct ggaccgaacg ctgttcctag atagatccct tcgggaacat
      121 gctgtgtgca tcgtcgggct tcggctagat gggcccaggc gtctcccggg tcgtacgcgc
      181 gagcagcgac aacggctgca cgcatgtgca gggctcccac cgctgcgagt gccgataccg
      241 agcttccctc gcgatggccg acgttgtccg cggcgctggt gagggcacgg cgcgcggtgg
      301 ctaggtcacc tgtgacgaag aaggtctcgg tccgtacata ggaaacagct gcttgcacca
      361 gtggatcatc cgcctgcgcg gcgagacgcc gcatatggtc gacgatgcgc gccgacaggt
      421 ccaggaatcc agatttatac gccagcccgt cggcggcgcg gtaggccaga gtagccaggc
      481 gcaacgcttc ttctcggctc tcgcaggtgg cctgcgctac cgcgcgtgcc aactcatcga
      541 gtacatccgg caactccagc gatagcgccg agtagcgagc ttgtagtcga tgggcgttca
      601 atcgccgcac agccgtgcgg agcgcgggca acgatcgtat gttcccatcg ggtggcgtgt
      661 cccatcgatc cagagccatg cgcaggctgg ccacccccga tgtaattggg tcagccccag
      721 acgaacccga agggtcatgt tcgtacacgc cgatgaggct gtcgtccctg tcctgtactg
      781 gggtggaaaa ctcgtcggga gcgaaggcgt agagggactc caccgagatg ttcaggactc
      841 gggcgtaagc ctgaacatat tccggacgga tcgtgcgctt gccgttctcc atacgcgaga
      901 ccacggactt gtgcaaattt acagatgcgg ccatagccgc gaggctcaac cctgctgcct
      961 cgcgcgcgga tcgcaaacgg tgcgccagtt gcacacgccg actatagctg cgttgccacg
     1021 aggcgtggct ctcactgccg gacatagtca tacgactggc agacggacct ggaccggcca
     1081 caggtaacca gcagttcggt tgaccggtca tgtgcggctt cttcccggtt ggtgtggggc
     1141 tggatggtct cggtggcgtc ggacgatgtt cggggcaggc cggttgcctt tcaccgtccg
     1201 acgccgccgc cgtgctccga gcgaccacgt gcggggcccc gttgccctgt cgaggtttca
     1261 ggggcgggtg tggtcgtagg tgagcacggt ctgcgcggtg tcgcgcaggc gctccagcag
     1321 tgcgcgacag gcgctggtgt tcagcgcacc gctggtgtgc agcgtggctc gggcgcgctg
     1381 cactgatcgt tgtgtggctt cgagttcggc ttccatctcg cgcgcatccg tgctggtgct
     1441 gtgtggttgt ggggtcattg gttccctcgt tggttgccag cgttcgatgt gcgggatctg
     1501 gttgtgaccg agggcgagcg cagcggcgcg gacctggtcg gcggaggcgg cgctgatgtg
     1561 cacggtcgag tggtggtcgt ggattcgcag ctgaatgtcc gcctggtcga gacggtaggc
     1621 gcaggtgtga ctggtgtgcc gatccggttc tctccagctg cggacacctc cggcgcggcg
     1681 aatcgcacga caggtttcgt ccgggtcgct cgtggcgatc acggtcgacc accgttgcgg
     1741 tgtccgagcg cggtctgcgg cggtcatgcc aagaccagtc cgatggtggt caccgctgcg
     1801 agcatcgcga ccactgtgag ggccacgagg gagaacttca acgcggccgt gggtccggcg
     1861 aacgttcccc gtacgggtgg tcgtggcatc gcgctctcct ggattccggt catgaaccct
     1921 gttcggtcgg gtagggctcg gtagtgcggt gcggggcgga cgccagccgc gatggcttgg
     1981 tgcgccgcgt cgcgaccggc gtccgagtcg agaagactgg tcccgacgca gtctggcgcc
     2041 gccacggacg cgcagcgccc tggtcggtgc gctgtcgaac ggttgggagt accgcgttcg
     2101 ccggggatcc gcggggaaca ctccatcgtg atcaccacaa cctacgtgta tcaacctgac
     2161 aatatcgaac atacggtatt gaaggttgat aatcaacctt caatatgtgt tggttgatag
     2221 gagggggcga gatatccttc cgctacagca tcgcgcgggc tcgccgggcc ccacggtgcg
     2281 gcgtgacgtg ttcgagcgaa ggagaaccgg tgccagcggg aaacccaacg accaaaaaac
     2341 gactgttggg acgcgagatc gcctacatga tcgacaaaac cgggatctcg cagacgcaag
     2401 ccgccaagat cctggagacc agccagtcac gcatcgcggg cctgctcaac gggaccggca
     2461 cgatcacgcc cggcgacctg accctgctgg ccaccgggct cgggttcacc gacccggact
     2521 acctcgaagt gctgcgcgag ttgcgccgcg actatcacaa gcggggcttc tggaacaccg
     2581 gtcaccgtcg cgcctactcc gaggacattc gcctgcgcat cgacctggaa caacacgccg
     2641 acaagttctc cgcgctggaa gtcgagatcg tgttcggact gttccagtgc gagtcctacg
     2701 tgcgtgcgct gcacgccgac gagccgaaca tcaacgacgt ctcgctcgaa gacatgatcc
     2761 aggcccggct cgcgcgccag cagatcctcg acaccagcaa cccgcccagc atgcacgtcg
     2821 tgctctccga gtcctgcctg cgacgggtat ggggcgggcc cgaggtgatg cgcgaacaga
     2881 tcgatcacct gatcaaactc tccaaccggc cgaacatctt tttgcaggtc atgcccttcg
     2941 accagcccgc cggtcgccgc tcacccatcg gatgcccgtt cgtcgtgctc cgcgtgccca
     3001 ccccagggcg ggcgggacca ctggagatgg cctacgtcga gggccagggc gagatccgct
     3061 acgtcgacga cgaggactcg gtccgggtct acgaagacgc ctgggcacgg ctatccaacg
     3121 ccgccctccg atacgatgaa acccggtcgt tcctcaccga ggtcgaccgc gagttcgcga
     3181 accgatccgc ctagcgcccg atcgaggagg agtccccgag gccatgagca ccacccgccc
     3241 gcgcttcctc gaaaccgact tccgcaaagc cacccgaagc aaccccaaca aggactgcgt
     3301 acgggtcgcc cgtcacagcg accgggtcga gatccgcgat gacaaaaccg tcttcggctc
     3361 cgagcaggat caccgcctgc tgctcaccgc cgcagaattc gacgcctacc aggccgccat
     3421 ccgccacgac gctcccaccg tcgagcacct ggcgctcacg ctccagccag acggcaccta
     3481 ccggatgagc accgccaccc gcccggaggt gttcctggtg ttcaccgccg ccgagatcgc
     3541 cgcgttccat cacggcgtct gccaccacga gttcgaccac gacaccctcg ccgccgccta
     3601 aacccccgta tgcgggctga tcgttcagac cggcctcgtg ccttgcacgt gcagcatccc
     3661 gtcgggacct ggttcgagcg caaggttcgc gccatggatg tcgtgctcgg ccagcagttc
     3721 aacggttttc gtgtcacgcg agagcccgaa gagcgcctcg cagcaccgca aggcgagctc
     3781 gttgagcacg accgcccagt cacgcaaccc atcccgcagt atgccagggc agtgcagctc
     3841 tggtaggccg aagcggccca gccccgtggt ctgcacggtg agcgtgtcgt tgtcggggaa
     3901 gtgatcgagt ttcatccatt tcgtcagccg cagcggttcg tcctcggtcg gcagccccgc
     3961 atccgcggaa tcgatcagtt cgaaggtgca gaaatccagt ggccgcaccg agttcgccct
     4021 gccgtacgcc aacgcgaccg cgcgcggacc actcgtgcgc cggtggccac cccggaagat
     4081 acgtacaccc gacactgacc agccaccgcg caccgtgcaa gtcgctcgca tcaccggtgt
     4141 agaccggtgg caacggcgac acggcctcca ccggatcgca acgctcctca accagcccgc
     4201 tcgcgcgcat atccagaacc agcccacgca acggttcagc gagcaagtcg agcaccggtt
     4261 cgcccaccgg tcccggcgcc ggcacgaggt agcgcgccgt caccatgtcc ggcaggtcaa
     4321 gcctcaacgt ccgcatcccg ccatcgtgcc aacaaggaca cagcgcaccg ccaagacctc
     4381 cgtggacacc gccacgcgac gctggccgac ggattttcag cttgttgcta gacgagtctg
     4441 tagaggttgg cgaggcgcgc gaaggtgtgg gtgcggcggc gtggggcgtg gtcgatgagg
     4501 gcttgcatgg ttgagcagcc gagcggttgg cggctggccc agtcaggagc gagacgcgcg
     4561 gcttcggcga ggtaggtcag ggcttggtcg cggcgtttga gggcgagttc ggctgaagcc
     4621 atgagcagac ggtgaccggc ttcccagaat gcggggacgc cgccgttcgg gatggcagcg
     4681 ttgagtcgta cggcttcgtc ggggtttccg gcgcggatgg tgtgttcgat ggtttggaac
     4741 gcggcgacac ggggaccgaa gatggctgcc tcgctgaccc aatcgccttc tgctctggta
     4801 gcggcggctc tggcttcggc gagtaggtcg ccagcgcgcg ggtgtgctcc agcgagcgtt
     4861 gcggcggtgg cggcgttgaa caggaggttg ccgaatactc cggcgcgctg cgtgtcacga
     4921 tcgagcattc gtggttcgat gcgttctgcc gcgatggtgg ccacgcgttc ggcctctgcg
     4981 taccggtgtt gacgaacgag ggtccagacg aggtagcggg tagcgatggc agcttcgagc
     5041 tctggctggt cgcagtgacg ggcgtggtcc aggccctcgt gggcggcgat ccaggccagg
     5101 tctgtgcaac cgaatcggcc agctgtcccg gcagctagac ggtaggcggt ggatagcacg
     5161 cgttgcccag cgctgcgttg atcgtcagga gaggcgtgga cgaaccttcg tgcgtcgccg
     5221 agaaggacag ggagcgtgtc gatgagccga tcgtgttgtc cctcgacgta cgcagcccac
     5281 gcactgtgcg ctgcgatgtc cagttgggga aggctgagca gttcgcgatc gtcgtcggcg
     5341 aggtcgcgca tgccgggaat gtcctcgctc gcggtaatcg cggcgcgtag gtcttcgatg
     5401 cttcgctcgt tctggccctc gctgggggca ctgccgccga gagcttgagg tgtgacgccg
     5461 agcgcagtgg caagccggtc gatcgtggtt ggacgggcgg tgcgtcgctt gccctgttcg
     5521 atacgggcca cggtgtccgt gccgacctcg gctgcctcgg ccagttcctc ttgagagagg
     5581 tcacgggcct tacgaagtcg agccaggttc gccgctagat cggtcaccgc acgcgctctc
     5641 cgttctcgca gagcgcgaac ccgccggtgt tcacgacttc gagcgcgacc gcaatccgcc
     5701 tgattaggtc cggctttgtc tggtcggcca cctcgtcaag gtgatgcagg gtaacggagt
     5761 gaatctcggg gtcggtcagc tccagtgcct tgacctcgga ctcggtgatc aggccaccat
     5821 cgaataccca cgcgaatccc tcggggaggc gttcgttggt cggcgtgtag tcgatgacca
     5881 ccggtgcggc gaacgttcgc cgtattccga gctcttcata aacctcgcgg gcaacggttt
     5941 gccagggtgg ttcgtccgcc tcgaccgcgc cgccaggtag gtcgagatgt ggcttgtagg
     6001 tcggttcgac gagcagaaca cggccgtcgg cgtcgtagaa cactgcggca gccgaattcc
     6061 gtttccgatt cagcgaggcc acgtactcgt caaacggcaa caagtccatt ccagcattgt
     6121 acgaccaccc gctgtgccca cttctaggcc caaaacgcct agttccgttg gatcacggcc
     6181 acagacaggg cttcatgaac cgttccgtgc aaccaggcga tgtacgacga tcggatttac
     6241 gcgcgagcgg cgaagcacct cagcagagag tctgcaagct ggaagagaca cgatgaccta
     6301 ccgcgacacg atccgtaatg cctcgttggc gagagaagtc tccaacacca cgtcatgctc
     6361 gcgaacacga ggtggccggg acgtcgatga cgagctagtc gagagcgaaa cgcagcaggt
     6421 tctgcggtgc gtcatggaag atggcgactg cgcggggctg ggcgtgaagg cgttcgggtg
     6481 tgattgggcg ttgctctgtg tccagcgaag gcggctcttc gcagctagat ctcgtgtact
     6541 gggccagcga ggacaggttg atgtcggtgg cagcacgcgc agcgtcttca ggctccaggc
     6601 gaattggcaa cggctggcaa cagccagaca cttcactgtt ccgggtatgc cagtcgatgc
     6661 tgtacagaac cgacacacca acgagggaac cgaacggatg agcacgatga ccaccgaaac
     6721 ggccgcgtgt acaggatatt ggggtgattc gccggccgtt gcccgatagc tcacggcggg
     6781 gcggaatcga cccgagcgtg ttccgtcttg ccgtgttcca cccgctcgaa aacaacgacg
     6841 agaagcagtg cccgcgctac gaccattcat cgggaacgcg caggttcccc gggtttcgtg
     6901 ctgggtgtta tgggcttcga cgacgatttg gggaggaagg taatgcgttc tggatggggt
     6961 tttactcatc gcggtcgcgg tgatagcgcc gaggggcgtg ctcggcagcg tgagttcgtg
     7021 gctgcgatga atgcgcgtcc ggaggcgatc aggcgacgga tcgagaccgc tggccgccgg
     7081 aaggctgcgc ggcgtgagga tcttctggcg cgtgtggttg tggttgaccg gcgtgctgtt
     7141 cggtggggtc ggtaatgccg cggccgttgt cctggatgga gctggcgtac tcatttctgc
     7201 agcaggaggg caagtggcgg gcggtggcgt ttcgggcgct gcgcggggag atctcggcgg
     7261 accggttgct gggatacgcg aaggaattgc gcgagaccgc cgcggaagtg gaagagtcgg
     7321 tgcgccagag ggtcagttcg gagaccgcgc tcgattcggc tcctgcgggt gagggtgcgc
     7381 tgttgcggcc ggaggtggtc gattcgctga actcgatcca tgtgctctcc ggtagtggtg
     7441 cggtggcaat gttggagaac acgcgcactg ccgctgacct gcacgaactg ttgaaacgca
     7501 cggccttttc cttggctgag gccgcgaagc tggccatgga caacgctcaa gacctcgacc
     7561 ggtcacgcga gtcggcgccc ggagacccgc acccgcccgg aggtcagcat gatcagcgct
     7621 agctgcctgc ttcccgtgct gatactgacc gggttgtgcg ttgttggcgg ggtgcgggac
     7681 ggccgctgtt gcgtggactc cccgcgagag cagcggtatg gggaagccgg ggccgtcggg
     7741 gcgccgctgg gcggccccgg tctcccccat catctggcca caccccgcat ggggagtgtg
     7801 tgatggctga ccatggttgg cgggttcgcg cggaaatcgt gatccacgat cgcgacgacc
     7861 accgcgacaa ggttccaatt ctgctcgtac aaggaccgca gggctgggca ctgccgggcg
     7921 gattcgtgga gaacacctcg gtccgcgccg cgctggacga acatgttcgc gaacagaccg
     7981 gccttgactt ctccggcgac ctccaagaag tcgtgccggt gggtgttttc gaagtcgata
     8041 ccgggtatgg gtgggttctg gtgtttcagc ttgaggccgt tgccgaggcc gcgaaagccg
     8101 cacgtggccg atggttcgac ctgggagacg acctcccgtc accgacggac ccgtggtcgc
     8161 aggccacctt gccccgcagt tcgtgggtgg tccctcacga cgggctgccc aacgaggtcg
     8221 gctggcccct cgatcagatc ccccacgggg gcgcaccaac agaacctcac gacaacacac
     8281 cacccagtca gatccacgac agcgaagcac agggaaaagg acacgattca cggtgagcag
     8341 caagaacaac cggccaaacc agcgcatcgg acgggcggat caggaccgga tcgaggatgc
     8401 tcgccaagcg atgatgcacg agctgtggca tatgcgcgca ctcaggacgg tgcgggtatc
     8461 ggatgtattc atgcgcctgg gccgtgaaga gttcgcgccc gaggtggcgg tcgaggaagt
     8521 gtacgccgcg gcgaacgcgg tagtcaccaa gcgggatgag catgggcgtg cggtgtcgag
     8581 tatttcggcg ccgcagattc aggcgttcca gttggagcag gccgatgtgc gcccggggat
     8641 gcgggtgttg gagatcggct cgggtggggt gaacgcggcg atgctagccg agctggtcgg
     8701 cgacaccggt gaagtgatct cgatcgacat cgatcccgag atcaccgccc aagcccggcg
     8761 cctgctggac gccaacggat acaagcaggt tcgtgtagag acggcggacg ccgagaatgg
     8821 tttgccggag tcggcacctt tcgatcgcat cttgactacg gttggttgct gggacctgcc
     8881 accggcttgg atcacgcaac tcaccgacgg gggccggatc gtggttccgt tgcggatgcg
     8941 cgggttgaca cggtcgctgg ccctggatcg cagcggggac cggttcgtgg cccgctcagc
     9001 cgaaacgtgc gggtttgttg aagtccaagg cgcgggcgcg cacaccgagc ggatgctgct
     9061 gctctacggc gaccaggtcg cactgcgctt cgacgacaac aacggccccg acaacccaca
     9121 caccttgggt ggggtgctgg gcaccgagcg ggcaaccgcc tggtccggag tcaccgtggg
     9181 cggcatggaa tcgttcgagg acctgttgct gtggctggcc agcactctgc ccgggttctg
     9241 ttcgttcgct gtcgccgacg actacaaccc cgacgagcgt gccccacacc tggtggacgc
     9301 gggccagcgc tggttcccga ccgcgttcct gcattcggat caggcctcgt tcgcgtatct
     9361 ggtcagcgcc cgccgcgatg agggagtgtt cgagctcggc gcgcacgggt tcggcccggc
     9421 cgccgaggac gcggtggcga ccatggccgc ccagatccgc aactgggacc acgaccaccg
     9481 tggtggccct ggcccgcaga tcagcgtgtg gctctacaac acccccgaca aagccatgat
     9541 ccccgccgga gaccccgagg gatctgtggc ggtattcgac aaacaccact gccgggtgat
     9601 ggtctcctgg cccacccccg ccggataaat ccggcactca cttttggggc ttggtcaggg
     9661 atttggtgaa ggaaaccctt gatgaggaag gaagtgggtt cgtgatgtcc accgtagatg
     9721 ccacgctcgc tagtccggaa gcggttggtg aggacggttt tcggctggag ttcgcggtga
     9781 tcgagtccgc ggttccgttg gcgaagctgg gttgcaacac cagtgatggg tgcgggcaca
     9841 cctgtcaggg ctcagcgtgc aatagccagg ccaacaaccc gtcctaaccc tcaatcccgg
     9901 gtgcctcggt acgcgcctcg ctgtaccggg gcacccggca tccgcgtggt ttctcttgtc
     9961 gtttctggct ttcgctgtcg tgggaggagg tgtgtatccg atgagtgtgc cgcggttgta
    10021 tcggcattcc gggttcgtca tggtgcgcgc gagcaccggc cccggtgggc tggtgttgcc
    10081 ggatctggat ctgcatacca gcgaaaacgc cgcaaccacg gggaaaacgt ggctggaatg
    10141 gttgtggaac cgcgacgacg tacggcaggt ggtggagcac gccagccctg ccgtcgcgaa
    10201 caagatcggc gaggctttgt ctggggaagc cttgtcccgg cggcagtggc gccggttgtt
    10261 gaccacgaca tgttcctacg tgttgcggtg gcagcgccgg gcgaccccgt tcggctactt
    10321 cgccggaatc aacaccgcca cgatcggccc cgcgaccgag gtgattctcg gcgacgagca
    10381 ccagattcat cgccgcccgg atccccgcca cctcgacgag ctcctgcgcg agctcgaagc
    10441 caaccccgct gtggtggcgc agttgtcggt gatggtgaac aacgcgggta tcacgcgtgg
    10501 ggaccagttc gcggtcccga aacgcctcca caacaccacc actgcgcctg ggcaggccgt
    10561 gaccgcgctg tccgccgtgg aggtggcagt gcgccgcacc ccggcggtcg acgcggttct
    10621 tgaccgggcg gcgtccccga taccggccga aaagcttgtc accgagttgg agaaccagtt
    10681 ccccaccgcc accgccgagc agatcaccgg gttgctgggc gggttgatcg aggccggggt
    10741 actgctcacc gatcttcgcc ccgcctcgac cgtgcacgcc ccgcacacat ggatccacga
    10801 ccagctgaac aagaccgacc gcaccacgaa cctcacagcc cgccgcgcgg tcacggagac
    10861 gcgtacgcgt ctgcgagccc tcaccacccc gacaccagag aggagcccgt ctccccgcga
    10921 ggtcgggccg ggaagcggtg tggatctcgc actggatgct caggtgagcc tgcccgagcc
    10981 ggtcgttcat gaggccgaga tggccgcgtc ggtgttggcg cgggtatcgg cgcacccgtt
    11041 cggcgccccg gcctggcggg agtttcatca gcggttccgc gagcgctacg gcgcgggctc
    11101 actggttccg gtccgcgagc tggtctcgga ttccgggttg ggctatccgg ccgggtttct
    11161 cggcgcagcc cgcgaacccg ccccgcggct gctgtctgag cgcgatgccg tgctcgggga
    11221 ctggatccag caagccctca tcgacgggga caccgagatc gcgctgtcgg agtcgatgat
    11281 caaccggctc accgtcggcg acccaaccca ccatattcga ccggagcggg tcgaactgtc
    11341 tttcaccgtc cacgccaaca cgccaaggga tgtggatcgg ggccggttcg agttgtgggt
    11401 caccggcgca cccccagcgt cgagcagcat gtgcgggcga ttcaccgatc tcctctcggc
    11461 agccgagcag gaccggctcg ccgccaccta caccaccgaa atccaggatg cggtgttgcg
    11521 ggcacagctg tcgttcccgc cccgtcaggt gcgcaacgac acgatcgccc gcgccccgca
    11581 cctgctgccc tggctgctgc ccatcggtga acacaccccc gaccacgagc cgtacctcag
    11641 tcttgatgat cttggggtca ccgcagacgc cgcccgcttc tatctcgtgc accgcccgag
    11701 cgagaagctt gtaaatccct atgtgctgca cgcgttggaa caacccatgc aaaccccggc
    11761 gctggtgcgg ttcctcgccg agctaccgat cgcgcgcagc agcgtgtacg gtccgttcga
    11821 tttcggcgcc ttccgtaccg cacggttcct accccgcatc cggtatgggc gcagcatcct
    11881 tgccccggcc cgctggctgc tgtctgccgc ggatcttccc ggccccaccg cgccaaccga
    11941 cgggtgggat acggcgtttg ccgcgtggcg aacgcgatgg catgtccccg cgcgggtcgc
    12001 ggtgatcgac ggggaccaac gcctgcccct caatgtcgag gaccggaccg agcggagtct
    12061 gctgcgagcg ctggcacacc gcggcggcaa gctcgaactg tgtgaaacca gcccacccgc
    12121 cgaggactcg tggacgggga gtccggtgga gttcgtcgtt cccctcaccg tgcacaccac
    12181 accgaccccg cactggacgg gcgcggcgag cgagcccgtg ttcccggggg attccgggct
    12241 gctgaccgcg cgcctggaaa tccacccgca acgcggggac gcgatcctgt ccagctactt
    12301 gccccagctc acccgggaac ttccggacgg tgcgcggtgg tggtttcgcc gctaccacga
    12361 caccacccgc cccgactctg cccacgagct gcacctgacc atccgaagca ccggccacgg
    12421 cgaccatggt gccctcgccg cgctggtatc ccgatgggcg caggagctgc gcgcggccgg
    12481 gctggtgtcg cggctggtgt tcgacaccac ctggccgacc gccgggcgct acggcgccgc
    12541 cccggacgtg tgtgagccgc tgttcgccgc ggactcggcc gcggccctga ccgaaatcgg
    12601 gttcgctagc aggcacaaca tgccgatcga ggtggtggcg gcggtctcca tgctcgacct
    12661 cgccgcaggc gtcctcgacg atccggtgcg ggcgtggtcc tggtgtcgcg acgaactgcc
    12721 ccgccacgag gggcactgcc cccgcgacca ccagcaacaa gcccgggagc tccagcgagc
    12781 actggccgca accccggttg acaccgcgcg ggcggccatg tcggccaggt gggccgagcg
    12841 gcgcgtcgcc ctggacgact accgcttccg ggtggaccgt gatccggttc gggtggtgcg
    12901 tgcgttgctg cacgagcact tcgtgcgcgc cgtggccgtg gatccgggcc gggagcagaa
    12961 caccaaccgt ctcgtgcgcg ccctggccct gcagcagctc tcccgaaccc cgcagggcac
    13021 cccatgaccc cacccccacc ttcaacccca cctgcagcct cggccccgca gccgacctcg
    13081 acgtcgatgc cgggcatcga cgggtcgcgc gaggtggtgc tggcccggtt gacccagcag
    13141 ctggcccagc ccgtgaaccc gccggggcaa cgccagtccc tggccagcgg ggtgctcggt
    13201 gcggcgttgt ggcatctcga acgcgcccac tacggcatcc cggccgcccg cgaacgcgcg
    13261 cacacctgca ttagcaccgc gctggccgac ccgatcagca acgccgaggt agcgggcttg
    13321 ttcgccgggc tgcccgcggt cgcgttcgtg ctgcacaccg ccgaagcggt gattcccgag
    13381 taccagccgg tgatcgccga gttcgacacc cacctcatcc ggctggcgca tcgccgggtc
    13441 gacaccgccc aagcccggat ccgctccggg aagcccgcaa cattcggcga gtacgacttg
    13501 cttggtgggc tcaccggcat cggtgccctg ctcctgcgcc accatccggg caacgacgcg
    13561 ctgcaccggg tcctgaccta ccttgtcacc ctcacccagc ccctgcgccg ggacggggaa
    13621 aacctgcccg gctggtgggt cggtcacgcc ccggatccgc tgctgcccac cccgggcggg
    13681 cacgccaacc tcggcctcgc ccacggcatt actggcccct tggccctgct ctccctcgcc
    13741 catcggcgcg ggatccacat cgacgggcac cgcgaagcca tcgaacgaat ctgcgcgcac
    13801 ctcgaccggt ggcaacaccc cagcgacacc ggcacctggt ggccctactg gatcacccat
    13861 cacacctaca aacgcggtca ccacgatcag acccacccgg agcgcccgtc gtggtgctac
    13921 ggaaccccgg gtatcgcgcg cgcccagcaa ctcgccgcga tcgccaccgg cgacacgcgc
    13981 cgccaacagc gcgccgaaac cgcgctcgat gcctgcctgt ccgatcccga ccagctcgac
    14041 ctaatcacca gcaccgggtt atgtcacggg tgggccgggc tctaccacac caccgtgcgc
    14101 gccgccgccg acgcgcacac ccccgccctc gccgcgcacc taccccggct ggccacgcgc
    14161 ctggcccgcc acaccgcgga ggcgccacct gccgagtacg ggttcctcga cggcgcgacc
    14221 ggaaccgccc tggccctgca caccacaccg atcaacactc cgctctcgga ctgggaccaa
    14281 tgcctgctga caatctgaac cccaaccaca ccgtctgtcc ggaagcgctg cacgctgccg
    14341 tgcaccacgc gctcaccggt gccgcccttc cgttggttgc cgctgaacac ggcctcaacc
    14401 acgatgagct ccacgacgcg gtcgaagtat tccttcgcgc tggcgcgagc gcgctctacg
    14461 agtacagcag cgatcccgac tggtacagcg cgcacctgga gttctccgac tgggatcagg
    14521 ctgaacggat cgcgctactg actttcgagc cgctgctcaa catctggacc ggcagcggtc
    14581 tgctcgaacg ctggtggttc atccgcaaag cccccgcctg gcgcctgcga ctccaaccag
    14641 gccccaacgc aggcgacatc ctcgtcccga ccgccaacga tctcttcgac aagctcgtca
    14701 ccagccacac gctcgccgac tggcgccccg tgcgctacga acccgaagca cacgccttcg
    14761 gcggccccac cgggatccgc ctggcccacc agctcttcca cgccgactcg gttcacctgt
    14821 tcgcctacct cgcccacgat cagccaccga tcgggatccg cgaactatcc atcctgctgt
    14881 gcacggtgtt gtttcgcgcc gcggaccaag aagggttcga aaccggcgac atctggcacc
    14941 gcgtcaccta tctacgcccc agcaccgggc acgacagcag caccagcacc gggcaccaca
    15001 ccgaactcac cgaacaactc cgcaccctgc tgcgctacga cacccacccc ggcgggcccc
    15061 tattcggcga tgacggtccc ctgcacgaac tacagccgtg ggcacaggcc ttccacgact
    15121 gcggccacgc cctcgctgcg gtgaaccaca ccaaccaact ccaccgcgga ctccgcaacg
    15181 tcctcgccca ccacgtgatc ttccactgga accggtgcgg attcgaccaa cccacccagc
    15241 acgccctcgc ccacgccgcg gccaccacag cgttcgagct tcgccccgag ccagacccac
    15301 caccatgagc acccgcacca ggcatggccc cggtcatttc ccctcttcca gcacggagcg
    15361 atttccacat acaggagaaa cgatgatgtt gaccgcccac gtgctcatcg cgtggcgtcc
    15421 gcgacggccc ggcgatgagc aacccgaacc gcaagccgcc tacccgtatc tgaccgccgc
    15481 gagaccagac ggcgggatcg acgaatccac cgaagcgtgg caagaggcca cacgtcacca
    15541 gcagcgattg cgcgcggcga acacggacac cacgttcgcc gcgatcacgg tgtcctcgtc
    15601 ggtcgcggat ccttccgggg tcgccaccgc gctcgtgctc aaccgggccc gcagtgtgcg
    15661 ccgacatgac gcggtcccga acctcacgct cacccctgcc actccggagc aaaccagcca
    15721 gatcagcgca ctcgaagcgg ccgagtatct gcgcaccggc cacggactgg tcctcgatga
    15781 cagcatcgac gggtgcaacg ccgtcttgct cgcgctcgcg cgtcgagcat tgtgtggaga
    15841 cccgtgtgcg caagtggctc tggccgagtt ctgcaccgaa cacgacgccc tgccctggca
    15901 tcaacgccct ttcgacctcg cctccccggc ccgcgcggac acggaatctc gccgctgacc
    15961 accaccaggt ccacagggtg ttttgcttgc catgcagctg cttgtgacga tgtcgatggc
    16021 ggccgcactg ctggtatccg gaagcggggc ggtgatcggc gcgctcgcgc tgcgcgtcgg
    16081 tcgcgctcgc caccaacaac gacgcccccg cattcctgat tccagggcgc agatgcgggt
    16141 acgcgaaacc cggtgccgcg aaggcacgcc cgtggaatcc acgatgccac ttcccctgat
    16201 cgccgacgaa ccgcccgacc atcaccccgt cagacccgat ccgacctcgt gaccaactcc
    16261 accatggccc atgacaatcc gaaagatcag tgaaaagatg acaggcgacc gaaagaccga
    16321 agcggccgcg ccgatcacca ccttgctgga ttcctcgtat ggctacgacc gagaaacgct
    16381 tgttctccgg gcgcaacaac agtggaacag ccagttcggc acccagcggc cgtgggagca
    16441 ggccaccgac aacgagcagc agcaatggct ccacctggtc gccgggcaga tcttgcagtg
    16501 tttccacgaa gccccggacc ccgcggattc cgttattccg atcgatcact cggcaccgtt
    16561 ctcgcctccc tacccggcag gcgccgacga actcgcgcac tggcatcgtc gagcagccca
    16621 gagcatcgac tggtaccggt atcgagcaca caccgacggg ctgcacatcg caggcgacac
    16681 cgaccagccc cagcatctgg tcctccagcc cgcctgggac agtcccgacc tgcccgatga
    16741 acatgtgcgc ggagaactgg acgaacgcat cagcttcctg cggatgctcg accaccgccg
    16801 cccgcgcccg agtggtgtcg acgaactcgc cgagctgatc accgctcaag ccgcccgcgt
    16861 gcagcacacc gaaacaggcc tgaggtccgg tgtcgataac taccgacgac gccggcacag
    16921 cgaagcccaa tcctggctat ccctgctccg cgaccggcaa cacaaccggg ccacgccaca
    16981 cctgtggcga acaggtgggc cagccctcgt gcgcgccctc gaaacacacg cgccacacct
    17041 gctgctcacc gagaccgatc gcgtccccga ggccctgatc gtgatcgccg ttcacgacca
    17101 cgcgcccgac aagccgttcg acctgttcga cgaaatccag gcctacgccg gaatctggga
    17161 cgagcacgcg atcgaaaaca ccctgcactc cgccatcgca ggcggcctcg tctgcctgca
    17221 accagaactg ggcgcactcc agctcaccga gaccgggcaa cggcgatacc agaacctcct
    17281 cgacaccatc cgcaacacac caccgaaccc agacggctga aacccaaccg agccccgacc
    17341 gacatcgcac tacccacgca aaggcaagga acccagccct catgaccgac tcgaccacca
    17401 ccgcccccgc acacccttac cagcgcttgg ctgacgagct gcgcgaacag atcctcaaag
    17461 gccacttcga acccgggcaa gtactaccca acggccgcga actcgccgcc gaacacggac
    17521 tgtcgagagc accagttctt cgcgctatgc agctactgcg cgacgaagga ctagtgcacc
    17581 tcgaacacgg ttgtcccgcg cgcgtcaaac ttcaaccaga aatccatcgc cttgcgcgaa
    17641 ccgcgatccc caccccctgc caggacccgg gtacgcgaaa ccccctcggc gaatccgaac
    17701 aaccggaatc acacgtttca ccgacggtac ggatccgatt ccagctcgcc ggagaacgct
    17761 tcgccgagat cctgggcatc gatcccgacg ccgaaatcac cgtgcgcgaa cacctccaac
    17821 gccccggcaa gcacgcgatc ctgcacacca cctcccggct accacgcgac ctcacccaga
    17881 acacacccat agaacgcacc aacagcacac ccgaccagct ctacccccaa ctcgaagcag
    17941 caggccacac catcacccac tacaccgaag aagtcggcgc acgcatgcca accccagacg
    18001 aactcgcccg attaggcacc accaacggaa tacccgtcct caccaccaca cgcatcaccc
    18061 actcaacaac ccggatcctc gaagtcaacg agtcaaccat gttcgccgac cgattccgac
    18121 tcacctacac ctggcccaac cacacaaatc accaaacaac cgaaccgcgc ccgcacatct
    18181 gacccctcca cgatcctgcg aacgattcag tgctattccc gttttttcac gctgatccct
    18241 ccccgcgagg caccgcgcac gtcgataacg agcacaaaac tccgccgtcg actgatcgac
    18301 ggcggagccg ggatcggcga tctcctgggg gaggtagaga tccagccgat cccgttccac
    18361 ggtacgaact cgacacagtc ttaggcacca atcgcgccga tttcacccgt ttgtcgcagc
    18421 gcagcgaccc cagaaaactc tccaaaccct cttgaccaac caggtcgacg gcaagcctcg
    18481 gggtgttacc gttgaaccgg accatcaccg cccgagcact ggtcgcgcgc cagccgcgtg
    18541 ctaccaagga cgctcgtatc cgcggtgccc cgcggatacg atttcttcaa ggcgaggagt
    18601 aaaccacgag ggggattgca tgatcggcaa taatcggagg ctgcatcgaa tgctgctggg
    18661 ggtaccggtg ggcgccgcgg cgatactgtt cggcgcgtcc ttgaccggat gcgccctgac
    18721 tcattcccac actcgttcgg gcttgtacgc ctcgacgtgc caggatgagc gaacccacgt
    18781 gcgcgtcgac tatcgacagt gcctaaaccg ggatcccgcg ctgcacttcg tgttctggcg
    18841 acccggtgat cactatcctg ccatcggcga gccaagccac aaccccctcg ccgcggtccc
    18901 aactgaccaa atcggctaca ccatcaccac acccggatcc ggtacagcac cacaacccga
    18961 ccgcaacgac tccgactccg gcagctacac cggaggcgga tactccggtg gctccggtga
    19021 cgaggaaggc ggttctggcg gcgaggaagg cggctccgga agcgaaggcg gtggctccag
    19081 cggcggtggc ggtggcgaat aggcacatcg acgtggaagt gctggtgccc caggcggtca
    19141 gcgcgaggca gcgccacagg tagttcgcat cccgacaggt gcccgcccgc ggtcatgacg
    19201 gagctctcga ccgccaccac gacgcacatg cggcgccgag gtctttccgc ggtacctgca
    19261 cgaacagatc atcacggatc cggacacctg gcaggaccgt cgcgccgagg cacgtacatc
    19321 atgcccgagc cccgtcacca tcccttttcc aacggcaggg aacccgcgct cgaacaagca
    19381 cgtcggttac cgaaccccca cagccaccgg gacttgtcga agggccgcga gctggggcat
    19441 gctcgccgcg gccgggccgt ggacatggtg tgacgcgaac accgcgacta gaaccgctgc
    19501 tggaccggta aggcgcagcg gggtggtgtt ggcgaacgac aaggtcacct gcgagcaacc
    19561 gaggttgggg tcgaccccgg tggtagccgc gtagtcgaac cgcaatgccg ttccccacgc
    19621 gtcgcagtac aagcggcggt cggtgatggt gaccatcgcg ccaacggggt cctcccagta
    19681 gggctgcgac atcttgcggg cgcggcgccg tccgagcatc ccggcggcca tggagccgag
    19741 caaagcacca gtcacgaact gcggcgatcc gaccactaat cgtcccggct ggtggtagtg
    19801 caccgggttc ggaacgatca ggcgactgta gtcgatgtcc tggatcatca agttcccaaa
    19861 cgcgacctcg ccaggatcca tggtgaacga cgaccacgtc gtgtcagggc gaatccccgc
    19921 ggacagctgg gcgtgcgcgc gggccgcttg ctgccaccac cgcgcggtat gggctgttcg
    19981 ggcttgccga ttcatcggaa ccccctgttc cggaatgaga ctgggtaaac gtcatgatag
    20041 ccggacgggc gggcgtcgtg gggtgccgcg cacgaggttc acacaggggt atgagcgacc
    20101 ggccatcatg gtctgttacg tccatattat ccgatttcgc tgaggttcga gtcctgtgtt
    20161 gtcgacgttg ctggcgtcga cgtgtcaaga tggggctggc tgcggaaccg atgtcagcgg
    20221 gcgctgaccg gcgtcacgtg ctgccgcagc tgggggatga gggtcatcag tatcaaggcc
    20281 atgaactggg tttgggagaa ttcaccgacg tctggcaccg aacttctgct actgctcgcg
    20341 atcgctgatt gtgctgacga ctatggaaga aatgcgtttc cctcgcgaac gacattggct
    20401 cggaaactgc gaatgaatcc cagtaccgtc cgcagactgg tcagaaaact ggagaacgcc
    20461 gggcagctga gggtcgaacg cagcgtcggc cgacaccaga cgaactcgta cagcctggtc
    20521 ttgcacaccg cccaggctcc tgtggaaaat cctgtggata aatcgccgga aaatggggca
    20581 ggttgccccg gggcgatctg ccccccaggg caatctgccc catcagggga ggcaactggg
    20641 accgaaaaag ggggcgcagc tgtgcccccc agaaccacca gaaccgtcct aggtggtgga
    20701 ggcgcgcgcg aaccgacggt tcacgacatc acgtccccgg cccctggaga tccgatcgcc
    20761 gacgccgtcc tggacggact cggttcagcg tggcacctga ccccagctca gcgttcccga
    20821 ttgcgtccgc gtatcctcga cgcgttattg aatggttggt ccatcccgaa tctcatctcc
    20881 tatttgtccg ccaacccccg tggcgtgcat tcaccattcg cggtcttatc caaaagaatt
    20941 gaagatttgc cgccgaatcg gccgcgaaaa caagctggta gccgaaagcc cgcgtggtgt
    21001 ggcgtttgcg acgaacacac gcgtcacgag gaaaccgcag ctggtctccg ccgctgccca
    21061 cgctgccatc cccacagaac catcaccgag cccatatgag gcggccaggc ccacgacgcc
    21121 gcgcgacttg cgagtgcgct ggaattctgc ctggccagca cgccgcgaac ggcattcgtg
    21181 aactgccgcc cagatcgtgc gattgacgtc ttccggcgac gcaccgacgc ggcgaccgcc
    21241 ccgcagcgca tcgaccacgg cggtaccgcc tcgctcgggg tcgtcgacat ccccacgacg
    21301 cgctcgaccg cgtcctgggt atccggcagc ctcctggcca gggcgacggc cctggccaac
    21361 gagaacatca agaccctcaa acgccgcctc gccgagcccg tcacccgccc gcagacctgc
    21421 cccgtgcgct cctcgcacac ccggcacacc tggaagaaca ccttcggcat caccgagggc
    21481 cgcgcgtttc gctccatcga acgccggggc cacctcggta ccgggatctc cggagaatac
    21541 atcggcgccg cgatcacccg cgccggcgaa cgtgccgggc tggccaccga ggcccgccgc
    21601 gccgggcacg atcccgtcgc catcggccgc cagggcggct ggtccgacgg atcggcggcc
    21661 ttactcggcg acatgcagat cgcggaccgt tgggacgaca acgccctcga agacatcggc
    21721 ctctaacccg cgtcgatcca cggatcccgt tgccaggtcc cggatcccaa gcgtgttttc
    21781 ccgcaccggg cggggccgga cggcatcctg gtgaccatgc ccatcactcc gcggatcgac
    21841 gagatgctca ccgagacggt gcggctgatc gtcgacgccg aaaaatgcga ccgtgaccag
    21901 atgacctttc gccccttcga gatctaccgc ggcaacaccc agatcggcag cggcgattac
    21961 accacctgcc acacctgccg cctcgtcgag ctcggcgaga tcggcttcat cgagcccgaa
    22021 cagcgccgcg gactcggcac acgaacactg ctgcggttgc gcgccctgct ccccggctac
    22081 cactggatcc tcaccccgac caaagccggt tcggccccgt tctggcaccg catgcaacgc
    22141 gcctaccccg acgagtacta cgacggccgc gacccgcgcg ggcgccgctg ccgccacatc
    22201 atctgacgag aaccgatcgg cgaatcccga ccggaatggc gctctcgacg aaacactcct
    22261 tgcccttcga gccgatcgtg agctcggagg gcagcgctac tggatccggc gcaacgatat
    22321 tcctactcca ctcagccaag gaacaagctc cggtctcgtc ctccgtgcct gacgttccgc
    22381 ttcggtcggc aaccggcgaa cacaggaata caacggggag ggcgccgtgc gcgacgccct
    22441 ccccgtttac tccacacaac accgtcacct cacggctctg gcaccgtcag gttagcgtat
    22501 tcgggatgca tcactcacag gctcagccag tttctccagc cccagccggt gattgaggca
    22561 ccctgcagca tctgcggaga cgagaggcgg acagatgcag ggaacggtcg gtccgtcctc
    22621 ttccacatcc ctggaacctg atcgcggcct cccgtagcag atttctcaag aacccgccga
    22681 gggtgtgtgt caacgcgacg atgatgcact ggttgacgcc aggaactgca tcatcgtcgg
    22741 cgagcccgac gtggacgtgc cataccgccg cgctccgcta gtcagctcgt caggtccttc
    22801 cgttacgagc gcacgaccgt ctcgacaccg tccgatggtt cgcccgaccg tcacgccaat
    22861 ccggtgctca gtaggtagtt gcaatggagc gttcgcagca gatctatttg gtaccccacg
    22921 ggccggttct tgactactag tgttcttggt atcggcggtc gcgattcatc atccgaatta
    22981 gccgagtcca tagcagtcgc gaacaaaacg gaaatggatt gtgcacgtgg tcaatcgagc
    23041 ccttttcagt tgaacgacgt ttccaagtcc agactcaaac atcactccga ctctttggga
    23101 ggcaccaaca catgtgcaag ttcagcgaac agcgccagtc caactatacc ggaccgggcg
    23161 accgaataac ggttactcca ttccatgagc cgcatgacaa actggagaag atgcgcgaaa
    23221 tcgtacggcg ttggcctatc ggtgaacctg actccgatgg ctggcagcgt tacaccgagc
    23281 tcaattcgtg ccatcgggcg ggtaagggct atgtggccat actgctgacg gttcagatcg
    23341 agcaccgctg gcccgtccat gccgtgcgct acggcgtaag cctgtttacg cgctagttcc
    23401 gcatcagcac ccgagaaaga gcgcgcctcc atcgcggtac tctgctccaa ttcgccgaag
    23461 aagcagagca gctgctccgg ctgaggttta atgaaggtga tgatcaggca cgggctttct
    23521 ttgacccaga ccgaacaccg atggcgtaat cacgcaaatt catggtggcg gggccgcgcg
    23581 gagtggccct gccacctcaa actccgatgg cgatgatgcg ccgatcagga gattactcac
    23641 gaatgttccg tccacctttt cctaccctgg aggagtcatg acctcatcgt ccgtctaccg
    23701 tctgctgttg agcacccccg gtgaaatgct ggccgctttg ccgctgttgc tggaccacac
    23761 gccagccgat tcctttgttt tcattggtct cgatgcgcag cgaggtctcg ttggcgcggc
    23821 gcggtgcgac accgacgcat cgcaggcacg cgaggctgtt cgtggcgcac tgggaacgct
    23881 catgcgcgaa ggcgctcgag cgattctggt tttcgtgata catccgctcc gggaagacgg
    23941 cgaacttccc taccgcgaca ccgtaggtga gacagcagag gacgtccggg cgatgggaat
    24001 gcaagtcgtt ggggcattct ggacaccccg agtgcagcat cgcgcacagt ggcgcaacta
    24061 cttcgacccg accgataccg ggctggtagc cgatccctac gctgcacggt tcaccggact
    24121 gtccgagaca ccgacgacgc tgtccgctac ccgagacgaa ctggccgcgt cgtacggcca
    24181 tgcggtcggc gagccggtgc tgcgcgtccg gaaacagcgg atcgagcgca cggagaccga
    24241 tccggctcta ctgcgtgagg cgttcgggcg ggccgtgggt tccgcgtcca agggccagtg
    24301 gagcccaggc gaggtcgagt tggtcgcctt ggcacaagcg ctcgcgagta agcccattcg
    24361 ggatgcggca atccgatacc tgctcgacga acgtgcgggc gctgcggagc tggttctcac
    24421 ttatctcgta cggcatcttc ctgcccccta ccggtgttct ccggcgttgc tgttcatgat
    24481 gttggaggct tctcagcgca gcggtccgcg tgcgagcatc ctgtttgaga tcgcacgtga
    24541 gtcagatccg gagaactcgc tggttcaaat atttcagcag atgcctttga acagtttccc
    24601 tccccaggtg atcagcaaga tgctgtcgaa actcacgaag aaagaaccgt agccctcgtt
    24661 ttcgatcaat acgttcgcga ccgtgggcca gtgatgcgcc gcgccaccgt gtcgaggtgc
    24721 ttttcgattg aactttcagt accccacggc ttgcatatta cctactagag ttcttcgcgt
    24781 cggcactgga gttgttgttc tagtcagccg agtcaaccgt aagtatgatc aagttggagt
    24841 gaattgtgca gtggaataat cctgccctct ttccgtgtag cgaccgggcc gtcgtcgtac
    24901 cgtcttcatg ggatggcgtg tactggcaag gaaattcgga cgcactggat gcgattgtgc
    24961 gcggtccgga tctcatgttc gccgaggccg atactgacgg catcgttcgg ttcgatagcc
    25021 ctcgacggat ctgccatgcc gcgcttgatc gtgatggcgg tgcatcgcgt gcattcgctg
    25081 tcatcgacga gacgttcccg tcggtctccg cgccgacctt ggttacccgt ccaggacata
    25141 gtcatgcggg ctcagcgatc ggactgtacc ggcctctccg actcgcggtg ctgctgtccc
    25201 agcagcaccc ccaccgagga gcacgtccgg tgtgcgcccc ggtccgtccg aatggattgg
    25261 tgtcgtggga gctcggggtg ctcctcgacc acattgagct caccgacc
//
