LOCUS       NZ_KB905392            20966 bp    DNA     linear   CON 29-MAR-2024
DEFINITION  Sciscionella marina DSM 45152 A37UDRAFT_scaffold_2.3, whole genome
            shotgun sequence.
ACCESSION   NZ_KB905392
VERSION     NZ_KB905392.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Sciscionella marina DSM 45152
  ORGANISM  Sciscionella marina DSM 45152
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Sciscionella.
REFERENCE   1  (bases 1 to 780868)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Sciscionella marina DSM 45152
            collection_date                   :: SEP 2006
            lat_lon                           :: Missing
            depth                             :: 516 m
            alt_elev                          :: Missing
            country                           :: China
            num_replicons                     :: Missing
            ref_biomaterial                   :: DSM 45152
            biotic_relationship               :: Free living
            rel_to_oxygen                     :: Aerobe
            isol_growth_condt                 :: 19196758
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Sand; Sediment; Marine; Aquatic
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi11892
            Current Finishing Status          :: Level 2: High-Quality Draft
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site :: Marine sand sediment at a depth of about 500 m,
            the northern South China Sea
            Cell Shape                        :: Rod-shaped
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28 C
            pH                                :: 7
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000379465.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 01:37:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,209
            CDSs (total)                      :: 8,146
            Genes (coding)                    :: 7,961
            CDSs (with protein)               :: 7,961
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 4, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 185
            CDSs (without protein)            :: 185
            Pseudo Genes (ambiguous residues) :: 1 of 185
            Pseudo Genes (frameshifted)       :: 52 of 185
            Pseudo Genes (incomplete)         :: 155 of 185
            Pseudo Genes (internal stop)      :: 15 of 185
            Pseudo Genes (multiple problems)  :: 34 of 185
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:59:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 307734
            Orig. end                         :: 328700
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB905392.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405877
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos  Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-PGF and JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20966
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="nucleoside"
                     /region_number="1"
                     /rules="(LipM or LipV or LipU or TunD or pur6 or pur10 or
                     nikJ or nikO or truD)"
                     /tool="antismash"
     cand_cluster    1..20966
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /kind="single"
                     /product="nucleoside"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20966
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10966](+)"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10966
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(LipM or LipV or LipU or TunD or pur6 or
                     pur10 or nikJ or nikO or truD)"
                     /neighbourhood="10000"
                     /product="nucleoside"
                     /protocluster_number="1"
     misc_feature    complement(58..71)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    1001..1016
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.07"
                     /tool="antismash"
     misc_feature    1347..1361
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.81"
                     /tool="antismash"
     gene            1385..1537
                     /locus_tag="A37U_RS53730"
     CDS             1385..1537
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666237.1"
                     /locus_tag="A37U_RS53730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Insertion element protein"
                     /protein_id="WP_240437608.1"
                     /transl_table=11
                     /translation="MERAAPFYCPYCGEEDLMPREDPRGAWRCESCRRVFSVKLVGLSV
                     TEVNS"
     gene            1534..2229
                     /locus_tag="A37U_RS0118335"
     CDS             1534..2229
                     /EC_number="1.8.4.8"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0004604 - phosphoadenylyl-sulfate
                     reductase (thioredoxin) activity [Evidence IEA]"
                     /GO_process="GO:0019379 - sulfate assimilation,
                     phosphoadenylyl sulfate reduction by
                     phosphoadenylyl-sulfate reductase (thioredoxin) [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020629419.1"
                     /locus_tag="A37U_RS0118335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoadenylyl-sulfate reductase"
                     /protein_id="WP_020498123.1"
                     /transl_table=11
                     /translation="MTTMETARLREIAEEGAALGEIGADAAMRWVAETFGDDFIIASNM
                     QDAVLIDVAARTKPDFDVLFLETGYHFAETIGVRDAVDLIYPGVRIVNAAAEQSVAEQE
                     AQYGKLNQTAPDRCCQLRKVVPLQRTLSRYSAWVTGVRRVDAPTRAQTPIVGFDERNGL
                     VKVNPIAAWTDEEFREYIEANGVLENPLVAEGYLSIGCAPCTAKVAPGADPRSGRWAGQ
                     TKTECGLHG"
     gene            2226..3170
                     /gene="cysD"
                     /locus_tag="A37U_RS0118340"
     CDS             2226..3170
                     /EC_number="2.7.7.4"
                     /GO_component="GO:0009336 - sulfate adenylyltransferase
                     complex (ATP) [Evidence IEA]"
                     /GO_function="GO:0004781 - sulfate adenylyltransferase
                     (ATP) activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000103 - sulfate assimilation [Evidence
                     IEA]"
                     /GO_process="GO:0070814 - hydrogen sulfide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="cysD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948063.1"
                     /locus_tag="A37U_RS0118340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfate adenylyltransferase subunit CysD"
                     /protein_id="WP_020498124.1"
                     /transl_table=11
                     /translation="MTTETIEEGKIIDEDAPVVADNIEALESEAIHIFREVAGEFDRPV
                     ILFSGGKDSTVLLHLAIKAFWPAPVPFPLLHVDTGHNFPEVLEFRDRMVDRHGLRLVVA
                     KVQDYIDDGRLSERPDGTRNPLQTVPLLDAINENRFDAVFGGGRRDEERARAKERIFSL
                     RNAFGQWEPRRQRPELWNLYNGRHSAGEHVRVFPLSNWTEADVWRYIEREDIELPSIYF
                     AHTREVFARDGMWLTAGPWGGPREGETVHRKQVRYRTVGDGSCTGAVESGADDVASVIA
                     EVSASRLTERGATRADDRISESAMEDRKREGYF"
     gene            3247..4557
                     /locus_tag="A37U_RS0118345"
     CDS             3247..4557
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416569.1"
                     /locus_tag="A37U_RS0118345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GTP-binding protein"
                     /protein_id="WP_020498125.1"
                     /transl_table=11
                     /translation="MSDLLRLATAGSVDDGKSTLVGRLLYDTKSVLADQLDAVTRASVD
                     KGLSTPDLSLLVDGLRSEREQGITIDVAYRYFGTPKRSFVLADTPGHVQYTRNTVTGAS
                     TAQLGVLLVDARNGVVEQTRRHATVLALLGVPRLVLAVNKIDLVGYDQSAFELIAKEFA
                     AYAAALGYTDEAVTTIPVSALVGDNVAESSANTPWYTGPTLLRHLESVPIATDPHDAPF
                     RFPVQYVIRPRTPEFPDYRGYAGQVASGTATVGDRVTVASNGATSTITAIDTYDGPLHS
                     AATGRSVTVRLADEIDISRGDLIAAEPDAPQPSTEIEATLCWLAEKELRPGARLLVKHG
                     TKTTQAMLGELTARFDEQSLSCVDAPENLSLNEIGQVRLRVAEPLPVDDYRTDPRNGSF
                     ILIDAGDGSTLAAGLVGSPLRALTSATGADTDVSPGP"
     gene            4625..5632
                     /locus_tag="A37U_RS0118350"
     CDS             4625..5632
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416568.1"
                     /locus_tag="A37U_RS0118350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_086010814.1"
                     /transl_table=11
                     /translation="MAAGCTRIQRTDEAERVPDQGPAAELRLGYFPNVTHAAALIGTGK
                     DLFTNRLGKTKLTPVQFNAGPDEVGALLGGSLDAGFIGSGPAINAFSKSEGSAVRMIAG
                     ATSRGAQLVVRPEIRTPDQLRGKTIATPQVGNTQDVSAKKWLATKGLTGKVNITSMQNS
                     QTLNAFRSGEVQAAWLPEPWSSRLVLDAGAKVLLDESSLWPGGQFPTTVLVVRTEFLHA
                     HPETVRALLRGELDAIDYAERDPAGAKAEVNAQLKKLTGKSLSGKVIDRAWADITVSAD
                     PLCSRFPALARDQQTAGITARSPEVSGMADLRALNEVRAQVHQPTISSAGLDKK"
     misc_feature    5159..5161
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5643..6434
                     /locus_tag="A37U_RS0118355"
     CDS             5643..6434
                     /EC_number="7.6.2.7"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020416567.1"
                     /locus_tag="A37U_RS0118355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_020498127.1"
                     /transl_table=11
                     /translation="MTAIMDELTDPIRTNAVRIERVSKSFSAEVHALDQVDLDVAPGEF
                     VCLLGASGCGKTTLLNLVAGLDRPSDGRIELATGRPAVMFQESALLPWLTAARNVELPL
                     KLAGIPRGQRKQRVEQLLELVRLGGLGRKRPHELSGGMRQRVALARALASTVDSAESGT
                     AKDVLLLMDEPFSALDAITRDVLQSELIRVWAQTGASVLFVTHDVREAVRLGQRVVLLS
                     SRPGKVVRDWHTADTDPDSEPELVDEINGALREVISAHATS"
     misc_feature    complement(5665..5679)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.99"
                     /tool="antismash"
     gene            6415..7299
                     /locus_tag="A37U_RS0118360"
     CDS             6415..7299
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010311724.1"
                     /locus_tag="A37U_RS0118360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_020498128.1"
                     /transl_table=11
                     /translation="MPTQPPDTVGEFEAGLDALDTPVRQQANAAARTRKFLRVVVPPLV
                     ALVGIIAIWQLLWALAFWPEYQLPAPLTVWDELWARLHTGEVFAILWTSLHRAVLGFLI
                     GVVIATPLGLLVAKVNVVRRAIGPLLTGLQSLPSVAWVPAAILWFGVTPTAIYVVVLLG
                     SVPSIANGLVSGIDQIPPILPRVGKALGAGRMAAARHILLPAALPGYLAGLKQGWAFSW
                     RSLMAAEIIARSPQLGKGLGAYLDDGRSFSDMPTVIAAIALILIVGIGIELLAFRPAER
                     SVLRARGLSGAPQ"
     gene            7296..8003
                     /locus_tag="A37U_RS0118365"
     CDS             7296..8003
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098912.1"
                     /locus_tag="A37U_RS0118365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sirohydrochlorin chelatase"
                     /protein_id="WP_020498129.1"
                     /transl_table=11
                     /translation="MNAPLIAVAHGSRDPRSAATITTLVDTVRARAPWLDVRVAFLELS
                     EPRLPEVLEQLHAEGHRRAVVVPLLLGEAYHATVDVPRIAAEAPLEVSTAPVLGPDRRL
                     ETVAWQRLERTGAGETDGIVLAAAGSSFEQANDLVRATARRWSDRLPTVAAFASAGAPK
                     LPEAVETLRAAGTRRIVVASWFLAPGLLPDRIAGQARSCGAPVADPLGVHPSVAAVVLD
                     RYLAATARDTLAA"
     gene            8000..8770
                     /locus_tag="A37U_RS0118370"
     CDS             8000..8770
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (6-247). E-value: 1.2e-47. Score:
                     154.2. Matches aSDomain:
                     nrpspksdomains_A37U_RS0118370_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098908.1"
                     /locus_tag="A37U_RS0118370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="enoyl-CoA hydratase-related protein"
                     /protein_id="WP_020498130.1"
                     /transl_table=11
                     /translation="MTELVHYTVSDGIATITLDSQHNRNALSRQLRGELRAALSGAQQD
                     EAVRVIVLTHEGPVFCSGMDLKEAGGAGAEDQGVNEFPAILDQLWTSETPVVVRLAGPA
                     RAGGVGMIAAADIVVAADEVNFAFSEVRIGVVPALISATVLPRLLPRPAHELLLTGAPF
                     SAARAAEIGLINSAVAAGELDAEVSRFTESLTLAAPNALAATKRLLRGERATNPADDFP
                     RLLELSAKHFASEEGQEGIHAFAEKRKPSWVPGQ"
     aSDomain        8018..8740
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0118370_ECH.1"
                     /evalue="1.20E-47"
                     /label="A37U_RS0118370_ECH.1"
                     /locus_tag="A37U_RS0118370"
                     /protein_end="247"
                     /protein_start="6"
                     /score="154.2"
                     /tool="antismash"
                     /translation="YTVSDGIATITLDSQHNRNALSRQLRGELRAALSGAQQDEAVRVI
                     VLTHEGPVFCSGMDLKEAGGAGAEDQGVNEFPAILDQLWTSETPVVVRLAGPARAGGVG
                     MIAAADIVVAADEVNFAFSEVRIGVVPALISATVLPRLLPRPAHELLLTGAPFSAARAA
                     EIGLINSAVAAGELDAEVSRFTESLTLAAPNALAATKRLLRGERATNPADDFPRLLELS
                     AKHFASEEGQEGIHAFAEK"
     gene            8786..9142
                     /locus_tag="A37U_RS0118375"
     CDS             8786..9142
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0118375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498131.1"
                     /transl_table=11
                     /translation="MNDAPDARGDPALLAAFPRHLAPITAPIFAELPETCLAPIEPIAR
                     TGSRWSDPARPVWPDPSVEGEKPRIPYRIYNPEPSETFLADLDVLERLLLACLYTRNHD
                     GFVRQRNLAPSEFG"
     misc_feature    complement(8789..8803)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            complement(9367..9642)
                     /locus_tag="A37U_RS44220"
     CDS             complement(9367..9642)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695714.1"
                     /locus_tag="A37U_RS44220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="barstar family protein"
                     /protein_id="WP_240437626.1"
                     /transl_table=11
                     /translation="MAHQLRAPGSKQQALAGIAEALAFPSWFGGNLDALFDCLIDLSWL
                     PEGQHVLVWTGTRALAEADPGAYAAIRDTLVDALTQRPLLRVVLVD"
     gene            complement(9775..9942)
                     /locus_tag="A37U_RS51620"
     CDS             complement(9775..9942)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS51620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498134.1"
                     /transl_table=11
                     /translation="MFEWWNQFALWLTGLQFWMQFALVMIVLVPVCAVVAFAADRVAGW
                     LGRLIHRRDS"
     gene            10001..10966
                     /locus_tag="A37U_RS0118395"
     CDS             10001..10966
                     /NRPS_PKS="Domain: PKS_ER (17-319). E-value: 2.7e-30.
                     Score: 97.5. Matches aSDomain:
                     nrpspksdomains_A37U_RS0118395_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     nucleoside: LipV"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005454992.1"
                     /locus_tag="A37U_RS0118395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_020498135.1"
                     /sec_met_domain="LipV (E-value: 1.6e-114, bitscore: 377.8,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 6.2e-06, bitscore: 21.7,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-19, bitscore:
                     66.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAVYAAKPNKEDPLAALEIGERPKPVAPEGWVKVDVKAASLNMH
                     DLWTLRGVGIKEDQFPMILGCDGAGVLEDGTEVVLHSVVPSPGWVADETLDPKRTLLTE
                     KHQGTFADSVIVPERNVLPKPAELSFAEAACMGTAWLTAYRMLFVKSGLRPGQTMLVQG
                     ASGGVSTALIALGKAAGLRVWVTGRSADKRAIAEGLGADATFESGARLPERVDGVFETV
                     GKATWSHSLKSLKPGGALVISGATSGDATAAELQRIFFLQLRVIGSTMGTRDELGSLLS
                     FCALTGIRPAIGTETPMSEARTAMQSMLDGETAGKIVLTR"
     aSDomain        10052..10957
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_A37U_RS0118395_PKS_ER.1"
                     /evalue="2.70E-30"
                     /label="A37U_RS0118395_PKS_ER.1"
                     /locus_tag="A37U_RS0118395"
                     /protein_end="319"
                     /protein_start="17"
                     /score="97.5"
                     /tool="antismash"
                     /translation="LEIGERPKPVAPEGWVKVDVKAASLNMHDLWTLRGVGIKEDQFPM
                     ILGCDGAGVLEDGTEVVLHSVVPSPGWVADETLDPKRTLLTEKHQGTFADSVIVPERNV
                     LPKPAELSFAEAACMGTAWLTAYRMLFVKSGLRPGQTMLVQGASGGVSTALIALGKAAG
                     LRVWVTGRSADKRAIAEGLGADATFESGARLPERVDGVFETVGKATWSHSLKSLKPGGA
                     LVISGATSGDATAAELQRIFFLQLRVIGSTMGTRDELGSLLSFCALTGIRPAIGTETPM
                     SEARTAMQSMLDGETAGKIVL"
     CDS_motif       10466..10525
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_A37U_RS0118395_0001"
                     /evalue="6.20E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="A37U_RS0118395"
                     /protein_end="175"
                     /protein_start="155"
                     /score="12.5"
                     /tool="antismash"
                     /translation="GQTMLVQGASGGVSTALIAL"
     gene            11088..12545
                     /locus_tag="A37U_RS0118400"
     CDS             11088..12545
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034806.1"
                     /locus_tag="A37U_RS0118400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid permease"
                     /protein_id="WP_240437609.1"
                     /transl_table=11
                     /translation="MVTRSGVVSSSGIFRRKPIGAIEPEAGPGLKRTLGLWQLTAIGIG
                     GIIGAGVFTLAGTVANEKAGPAVLISFLIAGIASAAAAFSYAEFAGLIPKAGSAYTYGY
                     AVLGEVVGWLIGWDLLLEYTAVVSVVAISISGYFNDLLSFLDIHLPLWMTGAPGTEPAG
                     VEPGSYKVNLIAVLLCLLIAFVLNQGMKNAARFETTLVFLKVGIVLVVIIAGIGHIKAG
                     NYTPFFPFGVTGAFSGAALTFFAVFGYDSMSTAAEESKDSQKHLPKAIVLSLAISMVLY
                     VLICLVLTGMITYTKIDPDSALSSAFASVGLPLLGAVIAIGAIIGVLTVLFTFMLGATR
                     IGYSMSRDGLLPSWFGKTSKRGVPSRFTWIIGGVAAILAGVLPIGEAAELTNIGILLAF
                     VVVCLAVIVLRYKRPELERGFRCPGMPIVPLIGVIFSLWLVTFLQPATWLRFAIWFVIG
                     MIVYGLYGYRHSKMSKGQDTESVTPNA"
     gene            complement(12578..13585)
                     /locus_tag="A37U_RS0118405"
     CDS             complement(12578..13585)
                     /GO_function="GO:0018580 - nitronate monooxygenase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018683158.1"
                     /locus_tag="A37U_RS0118405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitronate monooxygenase"
                     /protein_id="WP_020498137.1"
                     /transl_table=11
                     /translation="MLGAMFTQSPVILGPMAGGVSTPELVAAVSEAGGFAFLPSGYLSA
                     TEFATQWARTHELTDAPFGANLFVPGAQRAQGVREYAERLVPDALEYGIALGEARFEDD
                     EYAAKLELLIAQRAPVVSFTFGLPTDGDVRRLHAAGSTVVATVTTQGEAAAAAKIGVDV
                     LVAQGIEAGGHRGGFDPGQTTGTGLLALIGAITTALELPVIAAGGIMRPADVSAVRTAG
                     AVAAQCGTAFLRCPEAGTKQTHRNALAKGNRETTVTKAFTGRAARALSNTFIAKHDRYA
                     PTAYPQVHHLTKPLRTAAAEADDPERLHLWAGQGYRLGKEEPAAEVLRYLTPEQ"
     gene            13702..14235
                     /locus_tag="A37U_RS0118410"
     CDS             13702..14235
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]"
                     /GO_process="GO:0071555 - cell wall organization [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016763.4"
                     /locus_tag="A37U_RS0118410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VanZ family protein"
                     /protein_id="WP_020498138.1"
                     /transl_table=11
                     /translation="MRGEAELGAAEEMFSQPGVFAATVLGSLVIGVLAWFLAGRLGWSR
                     IAAALSACGLALALAVTLARPGVFSTPETSGNPFASCVDSQFSLSSTENKLNFAMLMPF
                     AFFGTIAARRPIVVMLCCAVLSGGIELFQAASGIGVCESNDFYTNTIGGILAACAGWVC
                     YSLFGTERYRTRQS"
     gene            complement(14243..14602)
                     /locus_tag="A37U_RS0118415"
     CDS             complement(14243..14602)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="A37U_RS0118415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_020498139.1"
                     /transl_table=11
                     /translation="MSTTRSISAEGSQVTEEYPVRPARANPPGIAGRILAWFSGAAAAA
                     LVLLALVLLGAVVVTALDDRPGPLAGTVVVHVLAALVTVVLQRFADRYPGRVRVLCSWA
                     VLVIFVVVLALYWWF"
     gene            complement(14602..15405)
                     /locus_tag="A37U_RS0118420"
     CDS             complement(14602..15405)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873239.1"
                     /locus_tag="A37U_RS0118420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="WP_040588122.1"
                     /transl_table=11
                     /translation="MPTRLIKVTPARLATWTDCPRRYRMTYLDRPTPPRGGAWAHSTLG
                     ASVHNALRAFFDLPPERRTPEEATALVRGCWKSEGFAGPEQSAEYRERAQGWVADYVEG
                     LDPGLEPVGLERWVAAPVGTIIAEGRVDRIDERDGELVIVDYKTGRHGLSTDEVRSSQA
                     LAMYATAARRTLRRECHTVELHHLPTGEVWQWEHSEATLERHVRRAEETAADLQLAKDT
                     LDAGGDPEILFEARPGRRCAWCDFRRSCPEGQQASAELEPWALLG"
     gene            complement(15446..16063)
                     /locus_tag="A37U_RS0118425"
     CDS             complement(15446..16063)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005451120.1"
                     /locus_tag="A37U_RS0118425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarC family protein"
                     /protein_id="WP_020498141.1"
                     /transl_table=11
                     /translation="MTFFDATLFAHSLITLLVIMDAPGNIPVFLALVGRKPREVRNRAA
                     RQGVLVSFGVIAGFAIAGGWILDYLGIGIAALQGAGGLLLLIVALDLLMDRESAQPKQV
                     EDVNIALVPLGIPLLAGPGAIATTIVFARQAEGNFGSYVAIGAAIIVAHLALYLVLRFS
                     GALIRVLREGGIVLLAKIAGLLVAAIAVNLIATAVRGFIAGG"
     gene            complement(16060..16920)
                     /locus_tag="A37U_RS0118430"
     CDS             complement(16060..16920)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949758.1"
                     /locus_tag="A37U_RS0118430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PHP domain-containing protein"
                     /protein_id="WP_020498142.1"
                     /transl_table=11
                     /translation="MRIDLHTHSHRSDGTDSPTELLENAVAAGLDVLALTDHDTTAGWP
                     EATAAVPAGLRVVPGAEFSCESETGRGGTCTVHLLGYLFDAEAPAIVAEQGRLRAQRRA
                     RVDRMARLMRADGYPVDPDALMAELPPDAPAGRPHLARALIGVGVVATVDEAFRLFLHS
                     RGRYHVAKRDTPVREAIAMVHAAGGVCVLAHPFAVTRGPTVTREVVAALAEAGLDGVEV
                     DHPDHAEPERAELRALAGEHGLLMTGSSDYHGENKVNRLGQETTSPEIFQRVLAMGTGA
                     KVIER"
     gene            complement(16991..17560)
                     /locus_tag="A37U_RS0118435"
     CDS             complement(16991..17560)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006237716.1"
                     /locus_tag="A37U_RS0118435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PH domain-containing protein"
                     /protein_id="WP_040588125.1"
                     /transl_table=11
                     /translation="MTPRDADDYLLASERRVIRVRRHWACLAWEVFETAALVAVAVMLS
                     YIVDPEWTIVQNILWYGALLVILRFAYQVVDWWVEQIIVTDKRVMLTTGVFTTQVAMMP
                     IGKVTDLTYERSANGRAFGYGTLVVESAGQIQALNRIEFLPRPEEVYDAISELVFGDKK
                     EQEERFSMRKAEQMARKRRLLDGNKR"
     gene            complement(17589..17750)
                     /locus_tag="A37U_RS52610"
     CDS             complement(17589..17750)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020668025.1"
                     /locus_tag="A37U_RS52610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_020498144.1"
                     /transl_table=11
                     /translation="MNVKKIVIIAAIALVAFFLITQPTSSANVVKNILGGLGDGAEAVV
                     SFAKNLVA"
     gene            17903..18304
                     /locus_tag="A37U_RS0118445"
     CDS             17903..18304
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420918.1"
                     /locus_tag="A37U_RS0118445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_040587982.1"
                     /transl_table=11
                     /translation="MRDPIRCVGAVIHDELGRLLLIRRGHEPERGRWSLPGGRVEAGET
                     DSAAVRREIAEETGLEVEVGPLCGTVTRGRYAIFDYTAAVTGGRPRAGDDAAELGFVTC
                     AEFDALDEAGELTTGLAEALRQWRVTPAR"
     gene            complement(18288..19400)
                     /locus_tag="A37U_RS0118450"
     CDS             complement(18288..19400)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009152643.1"
                     /locus_tag="A37U_RS0118450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2332 domain-containing protein"
                     /protein_id="WP_020498146.1"
                     /transl_table=11
                     /translation="MTELAALQGKLREFADSGEVAASPLYAHLAAQAAEDTEIAGLLTA
                     TEPEDAVPTLLLAAAHRLVIAEPISDLAEYYPSVGGTHGVDDQVWGTFRSFVLDRADRM
                     RELIGTRVVQTNEVRRAAAVYPAVALAAREAGGPIGLLEVGCSAGVLLGMDAYGYRYTL
                     GQSDQLTGGPVRSPLVLTADLALGTGAGKPKVPKKLHLSAKVGLDRHPVDVADEDELAW
                     LEACIWADQPERLRRFGLAASLVRAKPPELVTGDAVEGLEEAAERVPEHLPLVVLSSHV
                     LAYLDDERRAAFSARIAELGTRRQLWWVSKEANDAGLDAVFGERARLDHRRPENCAVGL
                     ARYPGNPNGRVDVEVLATATSHGDSLTWLV"
     gene            complement(19397..19909)
                     /locus_tag="A37U_RS0118455"
     CDS             complement(19397..19909)
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010229726.1"
                     /locus_tag="A37U_RS0118455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MaoC family dehydratase"
                     /protein_id="WP_020498147.1"
                     /transl_table=11
                     /translation="MQFGRFYEEFEVGAVYKHWPGKTVTEYDDHLFCLITMNHHPLHMD
                     ANYAEQTTDFGRNVVVGNYIYSLLLGMSVPDVSGKAIANLEVESLRHIKPTFHGDTIYG
                     ETEVLDKTPSKSKDDRGVVAVETRGYNQDGTVVCVFRRKVMVPKRSYGEARGGEQPGRP
                     EPKLDGK"
     misc_feature    complement(20112..20126)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
     misc_feature    20113..20127
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.89"
                     /tool="antismash"
     misc_feature    complement(20821..20835)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 gagacctatg ccagggacac cgcggacatc accgaccggc agaacgtgca gctgcactgg
       61 atccgcatcg aggatgtccc ggcgatctgg cagaagctcg aagccgtcgg cctgtccacc
      121 accgaggcct gcggggactg cccgcgcgtg atcctcggct cccccgtcgc cgggatcgcc
      181 gcggacgaga tcatcgacgc caccccggcc gtcgaggaga tcacccgccg ctacatcggc
      241 gacgagagcc tgtccaacct gccgcggaag ttcaagaccg cgatctccgg gtcaccgcgc
      301 caggacgtgg tgcacgagat caacgacgtg tcgttcatcg gctcggtgca tcccgagcac
      361 ggccccggtt tcgacgtgtg ggtaggcggt ggcctgtcca cgaacccgaa gatcgcccag
      421 cgcctcggag tgtgggtctc cctcgaggac gtgcccgagg tgtggcacgg cgtggtccag
      481 atcttccggg attacggcta ccgcaggctg cgtcatcgcg cccggatcaa gttcctgatc
      541 gccgactggg gtgtggaacg cttccgcgag gttctggaaa ccgagtacct gaaccggaaa
      601 ctcgcggaca acgcggcacc ggagatctac accggggcgc gcgaccacct cggcgtgcat
      661 ccgcagaccg acgggcgcaa ctacctcggc gtctccacca tcgccgggcg ggtctccggt
      721 tcgatcctgc agaacgtggc caaggctgcg gaacgggccg gttcccagcg gatccggacc
      781 acggtggaac agaacctgct cgtgctggac gtggaatcgg ccgaactgga cgggttgagc
      841 gcggagctcg attcgctcgg cctgcaggcg agtccctctc cgtggcgccg cggtgtcatg
      901 gcgtgcaccg gtatcgagtt ctgcaagctc gcgatcgtgg agaccaagcg gcgagccgcg
      961 gacgccgtgc tcgatctgga gcacaggctc gccgatgtca acgccgagct cgaacacccg
     1021 atcaccctca atctcaacgg ctgccccaat gcgtgcgcgc gtacccaggt cgccgatatc
     1081 gggctgaagg gccagatcgt caccgatgcc gagggcaggc aggtcgaggg tttccaggtg
     1141 cacctcggtg gaacactcgg cgtggacgcg ggtttcggcc gcaaggtgcg cggtctcaag
     1201 gtgaccagtg ccgaggcggt ggactacgtg gagcgcgtcg tgcggcgcta tgtcgccgcc
     1261 cgtgaaccag atgagcgatt cgccacctgg gtcgcccgtg cttcggatga tgaactgaaa
     1321 tgattgtccg gacaatgcac cgaggcaatg tccggacaat tcttcgcgat gaggaatccc
     1381 tataatggaa cgcgcggcac cgttttattg tccgtactgc ggtgaagagg atttgatgcc
     1441 gagggaagat ccgcgtggcg cctggcgttg tgagtcgtgc aggcgcgttt tttcggtgaa
     1501 acttgtcggc ctgagcgtga ccgaggtgaa ctcatgacca cgatggaaac cgcacggttg
     1561 cgggagatcg ccgaggaggg cgcggcactc ggcgaaatcg gcgccgacgc tgctatgcgt
     1621 tgggtggccg aaactttcgg tgacgatttc atcatcgctt cgaatatgca ggacgcggtg
     1681 ctcatcgatg tggctgcgcg caccaaaccg gatttcgacg tgcttttcct cgaaaccgga
     1741 tatcacttcg ccgaaaccat cggggtacgg gacgcggtcg atctgatcta cccgggcgtg
     1801 cgcatcgtca acgcggccgc cgaacaatcg gtcgccgagc aggaggcaca gtacggcaag
     1861 ctcaaccaga ccgccccgga ccgctgctgc cagctgcgca aggtggttcc gttgcagcgc
     1921 acgctttccc gctattcggc ctgggtgacc ggggtacgca gggtggacgc gccgaccagg
     1981 gcgcagactc cgatcgtggg cttcgacgag cgcaacgggc tggtcaaggt gaacccgatc
     2041 gcggcgtgga ccgacgagga gttccgggag tacatcgagg cgaacggcgt cctggagaac
     2101 ccgctcgtcg cggaggggta cctgtccatc ggctgcgcgc cgtgcaccgc gaaggtcgcg
     2161 ccgggcgccg atccgcgcag cggccgctgg gcgggccaga cgaagacgga atgcgggttg
     2221 cacggatgac caccgagacg atcgaagaag gcaagatcat cgacgaggac gcgcccgtcg
     2281 tcgcggacaa catcgaggcg ctcgagtccg aggcgatcca catcttccgt gaggtggccg
     2341 gggagttcga ccggccggtg atcctgttct ccggcggcaa ggactccacg gtgctgctgc
     2401 acctggcgat caaggcgttc tggcccgccc cggtcccgtt cccgctgctg cacgtggaca
     2461 ccgggcacaa cttccccgag gtgctcgagt tccgggaccg gatggtggac cggcacgggc
     2521 tgcggctggt cgtcgcgaag gtgcaggact acatcgacga cgggcggctg agcgagcggc
     2581 cggacggcac ccgtaacccg ctgcagacag tcccgctgct ggacgcgatc aacgagaacc
     2641 gcttcgacgc ggtgttcggc ggcggccgcc gggacgagga gcgcgcccgg gcgaaggagc
     2701 ggatcttcag cctgcgcaac gcgttcggcc aatgggaacc gcgcagacag cggcccgagc
     2761 tgtggaacct gtacaacgga aggcactccg ccggtgagca cgtgcgagtg ttcccactgt
     2821 ccaactggac cgaggccgat gtctggcgct acatcgagcg cgaggacatc gaactgccct
     2881 cgatctactt cgcacacacc cgcgaggtgt tcgcccgcga cggcatgtgg ctgaccgccg
     2941 gtccctgggg aggcccgcgc gagggcgaga ccgtgcaccg caaacaggtc cggtaccgga
     3001 ccgtcgggga cggctcctgc accggggcgg tcgagtccgg cgccgatgac gtggcctcgg
     3061 tcatcgccga ggtcagcgcg tcccggctca ccgaacgcgg cgcgacgagg gcggacgacc
     3121 ggatctcgga gtccgcgatg gaggaccgca aacgggaagg gtacttctga tcatgagcga
     3181 gctctgcagc gaatcatcga tacagcgccc gcgcgaagcg ccgagctccc ccggggagcg
     3241 agtgcgatga gcgacctttt gcggcttgcc accgcgggca gcgtcgacga cgggaagtcc
     3301 accctcgtcg gcaggctgct ctacgacacg aaatccgtac tcgcggacca gctcgacgcg
     3361 gtcacccggg ccagcgtcga caaggggctg tccactccgg acctctcgct gctcgtggac
     3421 ggactgcgct cggaacgcga acagggcatc acgatcgatg tggcctaccg gtacttcggc
     3481 accccgaagc ggtccttcgt gctcgccgac accccgggcc acgtgcagta cacccgcaac
     3541 accgtgaccg gggcgtccac cgcgcagctg ggcgtgctgc tggtggacgc gcgcaacggg
     3601 gtggtcgagc agacccggcg gcacgcgacc gtgctcgccc tgctcggggt gccccggctc
     3661 gtgctcgcgg tgaacaagat cgacctcgtc ggctacgatc agtccgcgtt cgagttgatc
     3721 gccaaggaat tcgcggccta cgccgccgcg ctcggctaca ccgacgaggc ggtcaccacg
     3781 atcccggtct ccgcgctcgt cggcgacaac gtggccgagt cctcggcgaa caccccctgg
     3841 tacaccgggc cgaccctgtt gcggcacctg gaatcggtgc ccatcgccac cgatccgcac
     3901 gatgctccgt tccggttccc cgtacagtac gtgatccgcc cgcgcactcc ggaattcccg
     3961 gactaccgtg gttacgccgg acaggtggcc tcggggaccg cgacggtcgg cgaccgggtg
     4021 acggtcgcct cgaacggggc caccagcacg atcaccgcca tcgacaccta cgacggcccg
     4081 ctgcactccg ccgcgaccgg ccgctcggtg accgtccggc tcgccgacga gatcgacatc
     4141 tcccgcggcg acctcatcgc ggccgagccg gatgccccgc agccgagcac cgagatcgag
     4201 gcgaccctgt gctggctcgc ggaaaaggag ctgcgtccag gcgcccggct actcgtcaag
     4261 cacggcacca aaaccaccca ggccatgctc ggcgagctca ccgcccgctt cgacgagcag
     4321 tcactgtcct gtgtggacgc accggaaaac ttgtcgctca acgagatcgg ccaggtgcgc
     4381 ctgcgcgtgg cggagccgct cccggtcgac gactaccgca ccgatccgcg caacggctcc
     4441 ttcatcctga tcgacgccgg cgacggctcc acactcgccg ccgggctggt cggctcccca
     4501 ctgcgggcgc tcacctcggc caccggcgcg gacaccgacg tctcccccgg accgtgagga
     4561 ccgaaccgtg aaccggcgcc gagcccgtcc gtccgcgcta ctggccgcgg ccctcctgtt
     4621 gctgatcgcc gccgggtgca cccgcatcca gcgcaccgat gaggccgagc gggtacccga
     4681 ccagggcccc gccgcggagc tgcggctcgg ctatttcccg aacgtcaccc acgccgccgc
     4741 gctgatcggc accggcaagg acctgttcac gaaccggctc ggcaagacca agctcacccc
     4801 ggtccagttc aacgccggac cagacgaggt cggcgcgctg ctcggtggtt cgctggacgc
     4861 cgggttcatc ggttccgggc cggccatcaa cgcgttcagc aagtccgagg gcagcgcggt
     4921 gcggatgatc gcgggcgcca cgagccgggg agcgcagctg gtggtgcgcc ccgagatccg
     4981 caccccggat cagttgcgcg gcaagacgat cgccaccccg caggtcggca acacccagga
     5041 cgtctcggcg aagaaatggc tcgcgaccaa gggactgacc ggcaaggtca acatcaccag
     5101 catgcagaac tcccagacgc tcaacgcctt ccgctccggc gaggtacagg cggcctggtt
     5161 accggagccg tggagctcgc gtctggtgct cgacgccggg gcgaaagtgc tgctcgacga
     5221 gagctcgctg tggcccggtg gacagttccc caccacggtg ctcgtagtgc gcaccgaatt
     5281 cctgcacgcg catccggaaa ccgtgcgcgc cctgctgcgc ggcgaactcg acgcgatcga
     5341 ctatgccgaa cgggatccgg cgggcgccaa ggccgaggtc aacgcgcaac tgaagaagct
     5401 gaccgggaaa tccttgtccg gcaaggtgat cgaccgagca tgggcggaca tcacagtgtc
     5461 cgccgatccg ctctgttccc ggttccccgc actggcccgc gaccagcaga ccgcgggaat
     5521 caccgcgcgt tcccccgagg tctccggaat ggccgatctg cgggcgctca acgaggtccg
     5581 cgcgcaggta caccaaccga ccatcagctc agctgggctc gacaagaagt gagggcgaga
     5641 cgatgaccgc gatcatggac gagctgaccg atccgatccg gacgaacgcc gtgcgcatcg
     5701 agcgggtctc gaagtcgttc agcgccgagg tgcacgcgct cgaccaggtt gacctcgatg
     5761 ttgctccggg cgaattcgtg tgcctgctcg gtgcttccgg ctgtgggaag accaccctgc
     5821 tcaacctcgt cgccgggctg gaccggccga gtgacgggcg catcgagctc gccaccgggc
     5881 ggcccgcggt gatgttccag gaatccgcac tgctgccctg gctcaccgcg gcgcgcaatg
     5941 tggaactgcc gctcaaactc gccggaatcc cgcgcgggca acgcaaacag cgcgtcgagc
     6001 agctgctcga actggtgcgc ctcggcgggc tcggccgcaa gcgcccgcac gaactctccg
     6061 gcgggatgcg ccagcgggtc gcgctcgccc gcgccctggc ctccaccgtg gacagcgcgg
     6121 agtccggaac cgccaaggat gtcctgttgc tcatggacga accgttctcc gcgctggacg
     6181 cgatcacccg ggatgtgctg cagtccgagc tgatccgggt ctgggcgcag accggtgcct
     6241 cggtgctgtt cgtgacccac gatgtccgcg aggcggtgcg gctcggccag cgggtggtgt
     6301 tgctgtcctc ccggccgggc aaggtcgtcc gggactggca caccgcggac acggacccgg
     6361 acagtgaacc ggaactcgtc gacgagatca acggcgcatt gcgcgaggtg atcagtgccc
     6421 acgcaacctc ctgacacggt cggtgaattc gaggcgggcc tcgacgcact ggacactccg
     6481 gtgcgacagc aggcgaacgc ggccgcgcgg acccggaagt tcctgcgcgt cgtcgtgccc
     6541 ccactcgtgg cgctcgtcgg gatcatcgcg atctggcagc tgctgtgggc gctggccttc
     6601 tggccggagt accagctgcc cgccccgctc acggtgtggg acgagctgtg ggcgcggctg
     6661 cacaccggcg aggtgttcgc gatcctgtgg acctcgttgc accgcgcggt gctcggtttc
     6721 ctgatcggcg tggtcatcgc gaccccgctc ggcctgctcg tggcgaaggt gaacgtggtg
     6781 cgccgggcga tcggcccact gctgaccgga ctgcagagcc tgccctcggt cgcctgggtg
     6841 cccgcggcca tcttgtggtt cggcgtcacc ccgaccgcca tctacgtcgt cgtgctgctc
     6901 ggttcggtgc cctcgatcgc caacgggctc gtctccggga tcgaccagat accaccgatc
     6961 ctgcccaggg tcggcaaggc actcggcgcg ggccgaatgg ccgcggcgcg ccacatcctg
     7021 ttgcccgccg cccttcccgg ctatctcgcc gggctcaaac agggctgggc cttttcctgg
     7081 cgttccctga tggccgccga gatcatcgcc cgctccccgc agctgggcaa ggggctcggc
     7141 gcctacctcg acgacggccg ctcgttctcc gatatgccga ccgtgatcgc ggcgatcgcg
     7201 ctgatcctca tcgtgggcat cggtatcgaa ctgctcgcct tccggcccgc ggagcgctcg
     7261 gtgctgcgcg cacggggcct gtccggagca ccgcaatgaa cgcgccgctg atcgccgtcg
     7321 cgcacggcag ccgcgatcct cgctcggccg ccacgatcac cacactcgtg gacaccgtgc
     7381 gggcccgggc accgtggctg gatgtgcggg tggccttcct cgaactgtcc gagccacgct
     7441 tgcccgaggt gctcgagcag ctgcacgccg agggacaccg gcgcgccgtg gtggtgccgc
     7501 tgctgctcgg tgaggcctac cacgccaccg tcgacgttcc ccggatcgcc gccgaggcac
     7561 cgctcgaagt cagcaccgca cctgtgctcg gacccgaccg gcggctggaa accgttgcct
     7621 ggcaacggct cgagcgtacc ggtgccgggg aaaccgacgg gatcgtgctc gccgcggccg
     7681 gttcctcctt cgaacaggcc aacgatctgg tccgggcgac cgcgcggcgc tggtcggacc
     7741 ggctgcccac ggtcgccgcg ttcgcctcgg cgggcgcccc gaaactgccc gaggccgtgg
     7801 aaaccctgcg tgcggcgggt acccggcgca tcgtggtggc ctcctggttc cttgcccccg
     7861 gcctgctgcc ggaccgcatc gccgggcaag cgcgttcctg cggggcaccg gtcgccgatc
     7921 cactcggggt gcatccctcg gtcgccgccg tcgtgctcga ccgctacctt gccgcgacgg
     7981 cgcgcgatac gctcgcggca tgacggagct tgtgcactac acggtctcgg acggcatcgc
     8041 gacgatcacg ctggactcgc agcacaaccg caacgccctg tccaggcagc tgcgcgggga
     8101 actgcgcgca gcgctgagcg gcgcacagca ggacgaggcc gtgcgggtga tcgtgctcac
     8161 ccacgaggga ccggtcttct gttccggcat ggacctcaaa gaggcgggcg gggcaggcgc
     8221 cgaggaccag ggcgtcaacg aattcccggc catcctcgac cagctgtgga cctccgagac
     8281 cccggtcgtg gtgcggctgg ccggcccggc gcgggcgggc ggggtcggca tgatcgccgc
     8341 cgcggacatc gtcgtcgccg ccgatgaggt caacttcgcc ttcagcgagg tgcgcatcgg
     8401 cgtcgtgccg gcgctcatct ccgccaccgt gcttccccgg ctcctccccc ggcccgcgca
     8461 cgaactgctg ctcaccggcg cgccgttcag cgcggcacgg gccgccgaga tcgggctgat
     8521 caactccgcc gtcgcagcgg gcgaactcga cgccgaggtg agcaggttca ccgaatccct
     8581 gaccctcgcc gcaccgaacg cactcgccgc gacgaagcgc ctgctgcgcg gtgaacgggc
     8641 caccaacccg gccgacgact tcccccggct gctcgagctc tccgccaagc acttcgccag
     8701 cgaggagggc caggaaggga tccacgcgtt cgccgagaag cgcaagccct cctgggtgcc
     8761 cggccagtag tcggcgcctt ccgatgtgaa cgacgctcct gatgcacggg gagatccggc
     8821 tctgctcgcc gcatttcccc gtcacctggc gccgatcacc gcaccgatct tcgccgaact
     8881 cccggagacc tgcctcgctc ctatcgagcc gatcgcgagg accggctcac ggtggtccga
     8941 ccctgcgcgc ccggtatggc ccgatccatc ggtggagggc gagaaaccgc ggatcccgta
     9001 tcggatctac aacccggagc catcggaaac gttcctggcc gatctcgacg tgctcgaacg
     9061 gctgctgctc gcgtgtctgt acacgagaaa ccatgatgga ttcgtccggc aacgcaacct
     9121 cgcgccatct gaattcggat gagccttgga tgatcccgtt cattgttcag ctactcggcg
     9181 aaatttcgat tcgttcttcg ggcagaatcc ggaattcatc gccctgaccg aattccgcgc
     9241 caccagttat cggaaccgct actaccgggc gcgatactcg cgcgcaacgg acccccgggc
     9301 tggccgctct ccacggctcg cgtgtgagca ggtcatgact cacctcacat tctcttggcg
     9361 ccgtcgctaa tccacgagca ccacgcgcaa cagcgggcgc tgcgtgagcg cgtccacgag
     9421 ggtgtcccgg atcgccgcgt aggcaccggg atcggcctcg gcgagcgcgc gggtgccggt
     9481 ccacacgagc acgtgctgcc cctcgggcag ccaggacagg tcgatgaggc agtcgaagag
     9541 cgcgtcgagg ttgcccccga accaggacgg gaaggcgagc gcttcggcaa tcccggcgag
     9601 ggcctgctgc ttggagcccg gcgcgcgcag ctggtgcgcg atctcaccgg gacgcaccgc
     9661 ttcgcgttcg gagtccgcgt gactcagttc atttgccaag gccgacccac caaccgagta
     9721 cgacgatcac cgcgagcgcg atgagggcga aggcgacccg cccgcgtgag gaattcacga
     9781 gtccctccga tgaataagcc tgccgagcca gcccgcgacc cggtcggcgg cgaacgcgac
     9841 gacggcgcac acgggtacca gcacgatcat cacgagggcg aactgcatcc agaactgcag
     9901 cccggtcagc cacagcgcga actggttcca ccactcgaac acgcttcgca tcgtacgcgg
     9961 gtggtgccca agcccgccca ggtatgtaag agtgacccct atgttcgccg tatatgcagc
    10021 caaaccgaac aaagaagacc cgctcgccgc actggagatc ggtgagcgac cgaaaccggt
    10081 ggccccggag ggctgggtca aggtcgacgt gaaggccgcg agcctcaaca tgcacgacct
    10141 ctggaccctg cgtggggtgg ggatcaaaga ggaccagttc ccgatgatcc tgggctgtga
    10201 cggggcgggc gtcctggagg acggcaccga ggtggtgctg cactcggtgg tgccctcccc
    10261 cggctgggtc gccgacgaga ccctcgatcc gaagcgcacc ctgctcaccg agaagcacca
    10321 gggtactttc gccgattcgg tcatcgttcc ggagcgcaat gtgctgccca agcccgccga
    10381 actcagcttc gcggaggccg cctgcatggg caccgcctgg ctgaccgcct accggatgct
    10441 gttcgtgaag tcgggtctgc gccccggcca gacgatgctc gtccagggcg cctccggcgg
    10501 ggtgtccacc gcgctgatcg ccctcggcaa ggccgcgggc ctgcgggtct gggtcaccgg
    10561 ccgcagcgcg gacaagcgcg cgatcgccga aggcctcggc gcggacgcca ccttcgagtc
    10621 gggagcacgg ctgcccgagc gggtcgacgg cgtcttcgag accgtgggca aggcgacctg
    10681 gtcgcattcg ctgaagtccc tcaaaccggg cggcgcgctg gtgatctccg gtgcgacgag
    10741 cggggacgcc accgcggccg agctgcagcg catcttcttc ctccagctgc gcgtgatcgg
    10801 ttccaccatg ggcaccaggg acgagctcgg ctcgctgctc tcgttctgcg cgctgaccgg
    10861 gatccgcccg gcgatcggca ccgagacgcc gatgagcgag gcgcgcacgg ccatgcagtc
    10921 gatgctggac ggggagaccg cgggcaagat cgttctcacc cgctagtcct tgtctcatcg
    10981 gacaacagat atcgcggatc gtcgtcccct ggaacagtgt ccatctggaa caccctgccg
    11041 tactgtcttg cgaaccgtag tcaccagtca gtgcaaggag taacagcgtg gtcactcgtt
    11101 ccggggtcgt gagcagttcc ggcatattcc ggcgtaagcc gatcggcgcc atcgaaccgg
    11161 aggccgggcc cgggctcaag cgcacgctcg ggctctggca gctgaccgcg atcgggatcg
    11221 gcgggatcat cggcgcggga gtgttcaccc tcgccgggac cgtggccaac gagaaggccg
    11281 ggcccgcggt actcatctcg tttctgatcg ccggaatcgc ctcggccgcc gcggccttct
    11341 cctacgccga gttcgccggg ctgatcccca aagcaggctc ggcctacacc tacggttacg
    11401 cggtactcgg cgaggtcgtc ggctggctga tcggctggga cctgctgctg gaatacaccg
    11461 ccgtggtctc ggtcgtcgcg atctccatct ccgggtattt caacgaccta ctcagcttcc
    11521 tggacatcca cctaccactg tggatgaccg gagcacccgg caccgaaccc gccggggtgg
    11581 aacccggctc ctacaaggtc aacctcatcg ccgtcctgct gtgcctgctg atcgccttcg
    11641 tactcaacca gggcatgaaa aacgccgccc ggttcgagac caccctggta ttcctcaaag
    11701 tcggcatcgt cctcgtggtc atcatcgccg gcatcgggca catcaaggcc ggcaactaca
    11761 ccccgttctt cccattcgga gtcaccggcg ccttctccgg agccgcactg accttcttcg
    11821 ccgtcttcgg ctacgactcc atgtccaccg cggccgagga atccaaggac tcacagaaac
    11881 acctacccaa agcgatcgtg ctgtccctgg ccatctccat ggtcctctac gtcctcatct
    11941 gcctggtcct gaccggcatg atcacctaca ccaaaatcga ccccgactcc gcactgtcct
    12001 cggccttcgc ctccgtagga ctgcccctcc tcggcgcggt gatcgcgatc ggcgccatca
    12061 tcggcgtact caccgtgctg ttcaccttca tgctcggcgc cacccgaatc ggctactcga
    12121 tgagccgtga cggactgctc ccctcctggt tcggcaaaac ctccaaacgc ggcgtcccca
    12181 gccggttcac ctggatcatc ggaggcgtcg ccgccatact ggccggagta ctgcccatcg
    12241 gcgaagccgc agaactcacc aatatcggca tcctgctcgc cttcgtcgtg gtctgcctcg
    12301 cggtcatcgt cctgcgctac aaacgccccg aactcgaacg cggcttccgc tgccccggaa
    12361 tgcccatcgt cccgctgatc ggcgtcatct tctccctctg gctggtcacc ttcctccaac
    12421 cggccacctg gctgcgcttc gccatctggt tcgtcatcgg catgatcgtc tacggcctct
    12481 acggctaccg gcactccaaa atgagcaagg ggcaggacac cgagtcggtc accccgaacg
    12541 cctgatcaag cggtccgggg cgaccggggt gctgccctta ctgctcggga gtcagatagc
    12601 gcagcacctc ggcggccggt tcctccttgc cgagccgata gccctggccc gcccacagat
    12661 gcaggcgctc cggatcgtct gcctccgcgg cggccgtgcg cagcggcttg gtgaggtggt
    12721 gcacctgcgg ataggcggtc ggggcgtacc ggtcgtgttt ggcgatgaac gtgttgctca
    12781 gcgcccgcgc cgccctcccg gtgaacgcct tggtcaccgt ggtctcccgg ttgcctttgg
    12841 ccagtgcgtt ccggtgggtc tgcttggtgc ccgcctcggg gcagcgcagg aacgcggtgc
    12901 cgcactgcgc cgcgaccgcg cccgccgtgc gcaccgcgga cacatcggcc gggcgcatga
    12961 tcccgcccgc ggcgatcacc ggcagctcca gggccgtcgt gatcgcaccg atcagcgcga
    13021 gcaagcccgt tcccgtggtc tgccccggat cgaatccgcc ccggtgcccg cctgcctcga
    13081 tcccttgcgc gacaaggaca tccacgccga tcttggctgc cgcggccgcc tccccctgcg
    13141 tggtcaccgt ggccacgacg gtactgcccg ccgcatgcag cctgcgcaca tcgccatcgg
    13201 tgggcaaccc gaaggtgaac gacacgaccg gcgcgcgctg ggcgatgagc agctcgagct
    13261 tcgccgcgta ctcgtcgtcc tcgaagcgcg cctcgccgag cgcgatgccg tactccaatg
    13321 cgtccggaac gagccgctcc gcgtactccc gcactccctg ggctctctgc gctcccggga
    13381 cgaacaggtt cgcaccgaac ggtgcatcgg tcagttcatg cgtgcgcgcc cattgcgtgg
    13441 cgaactccgt cgcgctgaga taaccggaag gcagaaaggc gaacccacct gcctcgctca
    13501 ccgcggcgac gagctccggg gtgctcactc ctccggccat ggggccaagg atcacgggag
    13561 attgggtgaa catggcgccg agcataggtg cacgtgaacg gcacggcagc gcacggaagc
    13621 gtgaactacg tcccaccgcc gcgaggcaac ccgttcgtgc gaacgcgcgt cgctagcagt
    13681 gaaaccggga aggggaatcg aatgcgtggt gaggccgaac tcggcgccgc cgaggagatg
    13741 ttcagccagc ccggtgtgtt cgccgccacc gtgctcggct cactggtgat cggcgtgctc
    13801 gcctggttcc tcgcgggccg gctcggctgg tccaggatcg cggccgcgct ttccgcgtgc
    13861 gggctcgcgc tcgccctcgc ggtcaccctc gcccggcccg gggtgttctc caccccggag
    13921 accagcggca atccgttcgc ctcctgcgtc gacagtcagt tctccctgtc cagcacggag
    13981 aacaagctca acttcgcgat gctcatgccg ttcgccttct tcggcaccat cgccgcccgg
    14041 cgccccatcg tggtgatgct ctgctgcgcg gtgctctccg gcggcatcga actcttccag
    14101 gcggcctccg ggatcggggt ttgcgagagc aacgacttct acacgaacac catcggcggg
    14161 atcctcgccg cgtgcgcggg ctgggtgtgc tattcactgt tcggcaccga gcgctaccgc
    14221 acccggcagt cctgacccgg ccctagaacc accagtagag cgcgagcacg accacgaaga
    14281 tcaccagcac cgcccaggaa cagagcaccc gcacccgccc cggataacgg tcggcgaacc
    14341 gctgcagcac cacagtcacc agcgcggcga gcacgtgcac gaccacggtc ccggcgagcg
    14401 ggcccggccg gtcgtccagg gcggtgacca cgacggcacc cagcagcacg agcgcgagca
    14461 gcaccagtgc cgcggccgcg gcacccgaga accacgcgag aatccggccc gcgatgcccg
    14521 gcggattcgc ccgcgcgggc cgcaccgggt actcctcggt cacctggctc ccttcggcac
    14581 tgatcgatcg agtggtactc atcagccgag cagcgcccac ggttcgagtt cggccgaggc
    14641 ctgctggccc tccgggcagc tgcgccggaa atcgcaccag gcacagcgcc ttcccggccg
    14701 tgcctcgaac aggatctccg gatcaccgcc cgcatcgaga gtatccttcg ccagctgcag
    14761 atcagccgcg gtctcctcgg cgcgccgcac atgccgttcg agcgtggcct cactgtgctc
    14821 ccactgccag acctcgccgg tcggcagatg gtgcagttcc accgtgtgac attcccggcg
    14881 cagggtgcgc cgcgccgcgg tcgcgtacat cgccagagcc tgggaggagc gcacctcatc
    14941 ggtgctgagc ccgtgccttc cggtcttgta gtccacgatc acgagttcgc cgtcgcgttc
    15001 gtcgatccgg tccacccgac cctcagcgat gatcgtgccc accggggcgg ccacccagcg
    15061 ctccagcccc accggttcca gtccgggatc gagcccctcc acgtagtcgg cgacccagcc
    15121 ctgtgcccgt tcgcggtact cggccgactg ctcgggaccg gcgaagccct cggatttcca
    15181 gcaaccacgc accagggcgg tcgcctcctc cggggtgcgc cgctcggggg gaaggtcgaa
    15241 gaacgcgcgc aaggcattgt gcacgctcgc gccgagggtg ctgtgcgccc aggcaccgcc
    15301 ccgtggcggc gtcggccggt ccagataggt catccggtag cgacgcgggc agtcggtcca
    15361 ggtggccagc cgcgccgggg tcaccttgat caaccgggtc ggcatgctct cgaaaccaag
    15421 ctgctgttgc gccacatccc caacgctacc caccggcgat gaacccgcga accgcggtcg
    15481 cgatcaggtt caccgcgatc gccgcgacca gcagaccggc gatcttggcc agcagcacga
    15541 tcccgccctc gcgcagcacc cggatcagcg cgccggagaa ccgcagcacg aggtagagcg
    15601 cgaggtgcgc cacgatgatg gccgccccga tcgccacata gctgccgaag ttgccctccg
    15661 cctgcctggc gaacacgatc gtcgtcgcga tggcccccgg accggcaagc aacgggatac
    15721 cgagcgggac cagcgcgatg ttcacatcct cgacctgctt gggctgcgcg gattcccggt
    15781 ccatgagcag atccagcgcc acgatgagca gcagcaggcc acccgcgccc tgcagcgcgg
    15841 cgatgccgat gccgaggtag tcgaggatcc agccgcccgc gatggcgaac ccggcgatca
    15901 ccccgaacga gaccagtacg ccctgccgcg ccgcccggtt gcgcacctcc cgcggtttgc
    15961 gcccgacgag cgcgaggaac accgggatgt tgcccggcgc gtccatgatc accagcagcg
    16021 tgatcagcga atgggcgaac agcgtcgcgt cgaagaacgt catcgctcga tcaccttcgc
    16081 accggtgccc atggccagca cccgctggaa aatctcgggg ctcgtggtct cctggccgag
    16141 ccggttgacc ttgttctccc cgtggtagtc gctcgagccg gtcatcaaca gtccgtgttc
    16201 accggcgagc gcacgcaact ccgcgcgttc cggctcggcg tggtccggat ggtccacctc
    16261 gacgccgtcc agcccggcct cggcgagcgc ggcgacgacc tcgcgggtga ccgtcggccc
    16321 cctcgtgacc gcgaacgggt gcgccagcac gcacaccccg ccggccgcgt gcaccatcgc
    16381 gatcgcctcg cgcaccgggg tgtcccgctt ggcgacgtgg tagcgccccc tgctgtgcag
    16441 gaacaaccgg aaggcctcgt ccacggtggc gaccacgcct accccgatca gcgccctcgc
    16501 cagatgcggt cgtccggcgg gcgcgtccgg cggcagttcg gccatcagcg cgtccggatc
    16561 gaccgggtac ccgtccgcac gcatcagccg ggccatccgg tccacccgcg cacgccgctg
    16621 cgcccgcagc cgcccctgct cggccacgat ggcgggggct tcggcatcga aaaggtagcc
    16681 gagcaggtgc acggtgcagg tgccgcccct gccggtctcg gactcgcagg agaactccgc
    16741 gcccggaacc acgcgcagcc cggccggtac cgcggcggtc gcttccggcc agcctgcggt
    16801 ggtgtcgtga tcggtgagcg caagcacgtc cagacctgcg gcgacggcgt tctcgagcag
    16861 ttccgtgggg ctgtcggtgc cgtccgagcg atgggagtga gtatgcaggt cgatgcgcac
    16921 gacgagggag cttatcgcga agccggccgc gacgttgatc gagaagctcc tggggtggtg
    16981 gtccgcacgg tcagcgcttg ttgccgtcca gcagccgccg tttgcgtgcc atctgctcgg
    17041 ccttgcgcat cgagaagcgc tcctcctgct ccttcttgtc gccgaagacc agctcggaga
    17101 tggcgtcgta gacctcttcc gggcggggaa ggaactcgat ccggttcagc gcctggatct
    17161 gtcccgcgga ctccacgacg agcgtgccgt agccgaaggc acgcccgttc gcgctccgtt
    17221 cgtaggtgag gtcggtgacc ttgccgatgg gcatcatcgc cacttgggtg gtgaacaccc
    17281 cggtcgtgag catgacccgt ttatcggtga cgatgatctg ttccacccac cagtcgacga
    17341 cctggtaggc gaatcggaga atgaccagca gcgcaccgta ccagaggatg ttctgcacga
    17401 tcgtccattc cggatcgaca atgtacgaga gcatcaccgc gacggcgacc agcgccgccg
    17461 tctcgaacac ctcccatgcc aggcacgccc agtgccgacg tacccggatc acccgtcgct
    17521 cgctcgcgag caggtaatcg tctgcgtccc gtggtgtcaa cgcggacacg gtgcgctgcg
    17581 acctccctct acgcgacgag gttcttggcg aagctgacga cggcttccgc gccgtcgccg
    17641 agaccaccga gaatgttctt gaccacgttg gccgacgagg tcggctgggt gatcagaaag
    17701 aaggcaacca acgcgatcgc cgcgatgatc actatcttct tgacgttcat ggcacctgcc
    17761 ctgtctgctc tgcgaattcg cggcaatcat actggcccac cacatagagt ggaaagccaa
    17821 cacgaaccaa acaccgttgt accgtgcccg gccctccggc gacagccacc ggacgggtgg
    17881 gaccgacctc aggggagtta ccgtgcgtga cccgatccgg tgtgtcgggg ccgtcatcca
    17941 tgatgaactg ggcaggcttc tgctcattcg gcgaggtcac gagcccgaac gcggacggtg
    18001 gtcgttgccc ggtggccggg tggaggccgg cgagaccgat tcagccgcgg tgcgcaggga
    18061 aatcgccgag gagaccggtc tcgaggtcga ggtcggtccc ctgtgcggca cggtgaccag
    18121 ggggcggtac gcgatcttcg actacaccgc ggccgtcacc ggtggccgac cgcgcgccgg
    18181 ggacgacgcg gccgagctcg gtttcgtgac ctgcgccgag ttcgacgcgc tcgacgaggc
    18241 gggcgaactc accaccggcc tggccgaggc gctgcgacag tggcgggtca caccagccag
    18301 gtgagcgagt cgccgtgcga ggtggcggtc gcgagcactt ccacatccac tcggccgttc
    18361 gggttacccg ggtaccgggc caggccgacc gcacagttct ccggccttct gtgatccagc
    18421 cgcgcgcgct ccccgaacac cgcgtcgagg cccgcgtcgt tcgcttcctt actcacccac
    18481 cagagctgcc gccgggtacc gagctcggcg atccgcgcgg agaaggcggc ccggcgctca
    18541 tcgtccaggt aggcgagcac gtgcgaactg agcaccacca ggggcagatg ctcgggaacc
    18601 cgctccgcgg cctcctcgag cccctcgacc gcgtccccgg tcaccagctc cggcggtttg
    18661 gcccgcacca gcgaggcggc cagcccgaac cggcgcagcc gctccggctg atcggcccag
    18721 atgcaggcct cgagccaagc gagctcgtcc tcatcggcca catccaccgg atgccggtcc
    18781 agccctacct tggcggacag gtgcagcttc ttgggcacct tcggtttgcc cgcgccggta
    18841 ccgagggcca ggtccgcggt gagcaccagg ggcgagcgga ccggtccacc agtgagctga
    18901 tccgactgcc cgagcgtgta gcggtacccg taggcgtcca tccccagcag cacgcccgcg
    18961 ctgcagccga cctcgagcag gccgatcggc ccacccgctt cgcgcgcggc aagggcaacc
    19021 gcgggataga cggccgccgc cctgcgcacc tcgttggtct gtaccacccg ggtgccgatc
    19081 agctcgcgca tccgatcggc gcgatcgagc acgaacgagc ggaacgttcc ccagacctga
    19141 tcgtccaccc cgtgggtgcc gcccaccgag gggtagtact cggcgaggtc actgatcggt
    19201 tcggcgatca ccagccggtg cgcggccgcg agcaacagcg tcgggaccgc gtcctccggt
    19261 tcggtcgccg tgagcagccc ggcgatctcg gtgtcctcgg cggcttgcgc cgcgagatgg
    19321 gcgtacagcg gcgaggcggc cacctcgccg ctgtcggcga actcccgcag tttgccctgc
    19381 agtgcggcga gttcggtcat ttgccgtcca gcttcggctc cgggcgaccc ggctgctcgc
    19441 caccgcgcgc ctctccatag gaacgcttgg gcaccatcac cttgcggcgg aacacgcaca
    19501 ccacggtgcc gtcctggttg taaccgcgcg tctcgaccgc cacgactccc cggtcgtcct
    19561 tggacttcga gggagtcttg tccagcacct cggtctcgcc gtagatggtg tccccgtgga
    19621 aggtcggctt gatgtgccgc agcgattcga cctcgaggtt cgcgatcgcc ttcccggaga
    19681 cgtccggcac cgacatgccg agcagcagcg agtagatgta gttgccgacc acaacgttgc
    19741 ggccgaagtc ggtggtctgc tcggcgtagt tcgcgtccat gtgcagcgga tggtggttca
    19801 tggtgatcag gcagaacagg tggtcgtcat actcggtgac tgtcttgccc ggccagtgct
    19861 tgtagacggc accgacttcg aattcctcat aaaagcgtcc gaactgcacg acctctcctg
    19921 actatgtcgg cgcactcgtg ggaatgctca acctacctgt gttgcccggc tcctcgcgcc
    19981 gcacgctccc cgctcgcccg cacggaacca gcaccgggta cccagtgtgg ccggagcaag
    20041 agtattctcg acaactgtct gtgtgagagg acacccgaag gaggtgagga cgcggatgag
    20101 tccaagcgat agtgcgagcg gtcccagtac cacccgcgtc cccatcgagc tcggtcttcg
    20161 ctgacgaacc gagcgcagtc ggtcggggtc gcggcacgcc agttcgccaa gcccagcccc
    20221 gcgaagtccg gaggtgtccc atgcccgcca tccgtccact cggtggtctc cgtggccgtg
    20281 ccacccgcaa ggcaggcctc accgaggtca ccgcaccacc accgacctcg gcctatgtcg
    20341 tcgactgtgc cgtgtacgtc gacgggaagc ggctgcccgg gcactacacg cacaccgagg
    20401 ccgtggaaga ggtcgcgcgc cgcggcgagg gcttcacctg gatcggcctg cacgagccgg
    20461 acgacgaaca gatccagggt gtcgccgaga ccttcggtct gcacgagctg gccgtcgagg
    20521 acgcggtgca cgcgcaccag cgcccgaagc tcgagcgcta tgacgacatg ctgttcatgg
    20581 tgttcaagac gctgcggttc gtggagcacg agtcgccgca caccgccaac gagatcgtgg
    20641 acaccggcga gatcatggcc ttcctcggca aggagttcat cgtcaccgtc cggcacggca
    20701 accactccag cctggccaag atccgccggg cgctggagaa cgacccggag cagctggcct
    20761 acggcccctc cgcggtgctg cacgcgatcg ccgaccacgt cgtggactcc tacctcgccg
    20821 tggccgaagc ggtcgaggac gacatcgacg aactcgagac ccgggttttc gcgccgcgca
    20881 ccgtgatggg ttcggaatcc atctacctga tgaagcgcga ggtgctcgag atgcgccgcg
    20941 cggtgctgcc gctcgccgcc ccgctt
//
