LOCUS       NZ_KB891313            23891 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. ScaeMP-e10 B061DRAFT_scaffold_7.8, whole genome
            shotgun sequence.
ACCESSION   NZ_KB891313
VERSION     NZ_KB891313.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. ScaeMP-e10
  ORGANISM  Streptomyces sp. ScaeMP-e10
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 379700)
  AUTHORS   Stepanauskas,R., Sieracki,M., Masland,D., Poulton,N., Swan,B.,
            Garcia,M.M., Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C.,
            Tapia,R., Chen,A., Kyrpides,N., Mavromatis,K., Markowitz,V.,
            Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G., Pagani,I.,
            Pati,A., Goodwin,L., Nordberg,H.P., Cantor,M.N., Hua,S.X. and
            Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Improved High-Quality Draft of Streptomyces sp. ScaeMP-e10
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 379700)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   3  (bases 1 to 379700)
  AUTHORS   Stepanauskas,R., Sieracki,M., Masland,D., Poulton,N., Swan,B.,
            Garcia,M.M., Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C.,
            Tapia,R., Chen,A., Kyrpides,N., Mavromatis,K., Markowitz,V.,
            Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G., Pagani,I.,
            Pati,A., Goodwin,L., Nordberg,H.P., Cantor,M.N., Hua,S.X. and
            Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. ScaeMP-e10
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            Isolation Site                    :: Gulf of Mexico
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:00:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,185
            CDSs (total)                      :: 7,109
            Genes (coding)                    :: 6,996
            CDSs (with protein)               :: 6,996
            Genes (RNA)                       :: 76
            rRNAs                             :: 6, 1 (5S, 16S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 45 of 113
            Pseudo Genes (incomplete)         :: 82 of 113
            Pseudo Genes (internal stop)      :: 12 of 113
            Pseudo Genes (multiple problems)  :: 23 of 113
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:33:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 69122
            Orig. end                         :: 93013
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB891313.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405355
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23891
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23891
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23891
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13891]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13891
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    542..556
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 21.35"
                     /tool="antismash"
     gene            586..1977
                     /locus_tag="B061_RS0131905"
     CDS             586..1977
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380623.1"
                     /locus_tag="B061_RS0131905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="APC family permease"
                     /protein_id="WP_018515590.1"
                     /transl_table=11
                     /translation="MSTPGTPDTPGTPAPAAPEASPPLKRALGPKLLILFVIGDILGTG
                     IYATTGDVAGKVGGALWLPFAIGFVVALLTAASYVELVGKYPKAAGAALYTQKAFRIPF
                     LTFIVAFMVMCSGLSSASAAARAFSGDYLGEFTDAVPPTLIAILFILALAAINLRGVSE
                     SVKANVVLTLVEVSGLAVILGIGAYAVFSGDGEPSRLTQIETGGTGYALLTGVLGATAL
                     GFFAFVGFEDSVNMAEETKDPARNFPRAIFIGVAVTGTIYILVALVSSLLVDSRTLSES
                     SGPLLEVVKAGGVDFPPKLFALIALFAVTNSALINLMMASRLCYGMANERILPPTMGKV
                     LAGRRTPWVGIVFVSLLAIGLVSTGEIEGLGDTTSFLLLCVFGVVNIAVLVLRKDRVDH
                     RHFRTPTALPVLGAITSLVLASPLADRGADVYVRAGILLLIGIGLWAVNKAVMAAREKS
                     DRAAD"
     gene            2135..2548
                     /locus_tag="B061_RS0131910"
     CDS             2135..2548
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761232.1"
                     /locus_tag="B061_RS0131910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018515591.1"
                     /transl_table=11
                     /translation="MPGIDECLLEVMRLPGARGASVVDWTSGLALGTIGESPNGDHEAT
                     AAETAEVARMTAEQPAFAHLTAGGGSERSGEAPSTSVEDVIVTTQDGYHMLRFVETAFD
                     SSVFLHLWLSRSEGNLAMARLRLGELAERLVLA"
     misc_feature    2148..2163
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.51"
                     /tool="antismash"
     misc_feature    2507..2509
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2545..3357
                     /locus_tag="B061_RS0131915"
     CDS             2545..3357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007460866.1"
                     /locus_tag="B061_RS0131915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4388 domain-containing protein"
                     /protein_id="WP_018515592.1"
                     /transl_table=11
                     /translation="MSAIAADPGAPETDRLPVLSPMLQRLAAERATGALMRDRGTLYLA
                     DGQVVHAESPATPGIDVLLTTGGTLRHEGWWDAVAQAGAGRRVGRYLVDSGHVPGGALE
                     LCHLGALYDAAFFALAPTGTPARFRYGVSHWIGPVRPVPVAAVQRETLRRRELLDRIWP
                     DAACDSAPVVRAAAHPGDSPVPARQRAVLELADGVRTASDIALALGRSAFHILVDLRRL
                     AAAGQVEAVRAQPLPATASAHGRITLPEVTADPDIALLRRLRDALEAL"
     gene            3396..3863
                     /locus_tag="B061_RS0131920"
     CDS             3396..3863
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018492858.1"
                     /locus_tag="B061_RS0131920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_018515593.1"
                     /transl_table=11
                     /translation="MVPEAETRGVLDELQRLRARVPLLAGALAASTDGLVLAHDTPGIE
                     AEGVAALTAAALGVSIRMTEATGRGGFRELLVRGESGYIATYAAGSSAVLTLLAEDRIN
                     VGRLHLEGRRAGARIGELVDTALERAERTPPMPRTAPSRGAPNRTLPQRPT"
     misc_feature    3444..3446
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3975..4349
                     /locus_tag="B061_RS0131925"
     CDS             3975..4349
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008417686.1"
                     /locus_tag="B061_RS0131925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018515594.1"
                     /transl_table=11
                     /translation="MANTEASLKEAMSSIEGTTGVALVDYTSGMALGTLGGGKDFNLEV
                     AAAGNTDVIRAKLRTMEHLGIKEEIEDILITLGTQYHLIRLLKTRGSNGLFLYLVLDAS
                     RANLAMARHQLKKIEAELEV"
     gene            complement(4498..5037)
                     /locus_tag="B061_RS0131930"
     CDS             complement(4498..5037)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515595.1"
                     /locus_tag="B061_RS0131930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018515595.1"
                     /transl_table=11
                     /translation="MAVIVRAGAAPLWWAGLVAAAAGAFVPGLTGRRIGLLTGAALFIV
                     TAAFVLLARGGRYAELARGASRTGRGDFLQDRAVTVRVWRRGHRWWLLGAFVAAVASSF
                     ALPGAGGLVLAGAGAGLWAKAVRIGQRERRDDVLYWVRTDWAGRGSPVAKGVQGHRTTG
                     PVAGDAAPGGARRRRR"
     gene            complement(5197..6042)
                     /locus_tag="B061_RS0131935"
     CDS             complement(5197..6042)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006125088.1"
                     /locus_tag="B061_RS0131935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MurR/RpiR family transcriptional regulator"
                     /protein_id="WP_043186471.1"
                     /transl_table=11
                     /translation="MSGSSPAARLQQLFEGHRLTPTQRRIAHCMVRRAADAPFLSSVEL
                     AELAGVSQPSVTRFAVALGFDGYPALRRHLREVAPADAEQEDAGETYNEYQQAVRAEIE
                     NLQHLSDLLADPGPVERAGRLLAESRPLPVLGLRAASSQARGFGYFAAKVHPDVRVLDE
                     GGSMLLDRIDAARRAGATALMCFALPRHPRESVEALAYAGEQGLTVVTVADSAFAPVAK
                     HSDLLLPAAIGSGLSFDTVCAPMLLGRVLLEAMCDELPDAQARLEEFDVRAAARGLFVE
                     "
     gene            complement(6177..7376)
                     /locus_tag="B061_RS0131940"
     CDS             complement(6177..7376)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009719400.1"
                     /locus_tag="B061_RS0131940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_018515597.1"
                     /sec_met_domain="p450 (E-value: 4.5e-16, bitscore: 53.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGATSRTPIMFNPLSEGFMEDPHPHYAEVRRHAPVHEHPGGFWM
                     VSRYEDVETLLRGEHSVDKRSARGATDSGRPPRLKGLALIDQDPPHHTRLRRLVSQAFT
                     PRAMSGIEPVVRALVDEALEELGRAGGGDLVEALAFPLPFAVITRILGMPEVDTVRLRE
                     LTSLLIRLGEPGAGSGAKDGIEAADAEMAELVSDAISRKRRARGDDLLTALIDAEDDGD
                     RLTHDELVAQVAMVYVAGYETTVNLISGGILALLRHPEQLDLLRTTPGLERNAIEELLR
                     YEPPVHLARRITLHPLLMAELAIPAGSVVLASLAGANRDEEFWGPDAGRLRLDRENARR
                     HVSFGGGAHYCIGGGLARIQGRIAIGELVRRFPDLEQAGEVRWNGLLSLRGPARLPVRI
                     "
     gene            complement(7373..8320)
                     /locus_tag="B061_RS37430"
     CDS             complement(7373..8320)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B061_RS37430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018515598.1"
                     /transl_table=11
                     /translation="MNSPAVLAATPLGKAAAIVRDYVLRMYYEVDEVPRLDRLRLTPLL
                     LGVEYLVYRVDSLAERNATVDLDAVRNDDYEAFHTYKKAFEKVLRALGAWNGDVAFLVD
                     EAERFVRLENGATSRGTVTRGDVLAMVELRPTDVRLLRAMAFALRGRPMEPATRDLLWP
                     VEVLADLANDLRHYEQDVAAGTLNVYAAFVELYGDAAATELRREADRYESMFLERLSAL
                     PPERRARIAEVCRPRYAAALEPYPRVVTARPVPAPPARPPGTYLRKGVVACAALTAGVL
                     AAAAHRRGRPRSSPLPIRSPLHLLPLHPKRGRAS"
     misc_feature    complement(7406..7408)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8359..9033)
                     /locus_tag="B061_RS37820"
     CDS             complement(8359..9033)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.4"
                     /locus_tag="B061_RS37820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_018515599.1"
                     /transl_table=11
                     /translation="MTGAGARTAPRLLVGSALSAAALTVLAVLVAAGSDAVGAFDAGAR
                     ALAARAFGPSAGPWPGAGGRADLAGSTLLAVLVVAALGVLLVRRRFGAALWLLGGLTAQ
                     FVAETVLGPLVGRASPVPADGTPPDAGFSFPSGHAASATLAVVVLVAVARARTGTPLWW
                     TWLGAGALLVLAVGVTRVVADAHHPADVVGGWLLGLTVGLAVAPRPGTSGARGKSGARG
                     KS"
     gene            complement(9030..9947)
                     /locus_tag="B061_RS37825"
     CDS             complement(9030..9947)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (38-229). E-value: 1.3e-31. Score:
                     101.1. Matches aSDomain: nrpspksdomains_B061_RS37825_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="B061_RS37825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_158689994.1"
                     /transl_table=11
                     /translation="MSANRQQVVDYFEGTRWDYRHLWRSEKAGALHFGFYDRRIRNHVT
                     ALRRMTGYLASVVGITPEDRIMDAGCGIGGCAIRIADHFGCRATGVNITPFQVTAAREA
                     AHRAGVDGLVEFVEADFTDTGLPDASHTVVWALESVVHVDDKEAFVREAHRVLAPGGRL
                     MIAEYLVREDPAPTPAQEEELATWCRGWAMPGLLTAGEYERLLHKQGFEDVRIVDISPY
                     VAPSLHRLRWLVRLLGPTAPAFRRLGVLAPVPADNLIASAAQIRMFDAGAWRYQVVTAR
                     KPAEPTGTPGDAVAPGHTPAEPTR"
     aSDomain        complement(9261..9833)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B061_RS37825_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.30E-31"
                     /label="B061_RS37825_oMT.1"
                     /locus_tag="B061_RS37825"
                     /protein_end="229"
                     /protein_start="38"
                     /score="101.1"
                     /tool="antismash"
                     /translation="RIRNHVTALRRMTGYLASVVGITPEDRIMDAGCGIGGCAIRIADH
                     FGCRATGVNITPFQVTAAREAAHRAGVDGLVEFVEADFTDTGLPDASHTVVWALESVVH
                     VDDKEAFVREAHRVLAPGGRLMIAEYLVREDPAPTPAQEEELATWCRGWAMPGLLTAGE
                     YERLLHKQGFEDVRIVDISPYVAPSLHR"
     misc_feature    9938..9952
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.54"
                     /tool="antismash"
     gene            complement(10001..11110)
                     /locus_tag="B061_RS40385"
     CDS             complement(10001..11110)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: TS_Pyr4"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B061_RS40385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018515601.1"
                     /sec_met_domain="TS_Pyr4 (E-value: 1.8e-24, bitscore: 80.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELAPSELRVVRDVGRVWDRPGDAELREALRPAETLAYVAWDLTQ
                     YANGTGTVGRTNIYAAFVDTYGDTAAERLREEVADFRGQFEKRVQALDVAERDRLLHAV
                     TLHCAPAWGDYPDPAAERHEEETTAEGVSSAVVLFGMLCVVGWLVAYAAIIYRGFADQT
                     YGVPLAALFANLTWEFAYGFLLDPLGDYFHTASIFGFLVDAVIAWQVWKYGAAQFPDSS
                     LGRYFRPIFGLCVAAALSVNYHAFIDLADPDGEYTGFGINLMMSILYIKMLEDRGSPSG
                     QSMYIAVGKWLGTLCAWIATALTVTTTPQRTWPTSWSDFTRQALGNRSYPLTPLINVMY
                     GWTFLLDAAYCVLLHRRIRAAGMSPWQRF"
     misc_feature    complement(10808..10810)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    11154..11168
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.91"
                     /tool="antismash"
     misc_feature    complement(11646..11663)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.39"
                     /tool="antismash"
     misc_feature    complement(11817..11835)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.98"
                     /tool="antismash"
     misc_feature    complement(11819..11834)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.59"
                     /tool="antismash"
     misc_feature    complement(11826..11837)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.41"
                     /tool="antismash"
     gene            11940..12830
                     /locus_tag="B061_RS37445"
     CDS             11940..12830
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (53-275). E-value: 2e-14. Score:
                     45.9. Matches aSDomain: nrpspksdomains_B061_RS37445_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014698.4"
                     /locus_tag="B061_RS37445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_018515602.1"
                     /sec_met_domain="TauD (E-value: 1.1e-13, bitscore: 45.9,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDHLHRIPGSLRAALDELRESPSLSALRISGARVEPERCGPTPL
                     TWQEALDDRRQDLEEAQLALLAAYLGEVFAWPTIQRGRMVQNLIPVESDREEQSGHGSV
                     ALEWHTEDGFHQDRCRYLGLLGIRNDDRVPTTIGSVHDVRLSAHHRSVLHQRRFLIRPD
                     LEHLRQLAELDPEDEALRRARAMNENPEPAALLFGDPEAPCLRIDAPYTTSLPGDDEAA
                     EALSAVVGELSRVQRDVVVGEGDVLIVDNYRAVHGRRAFSPRFDGTDRWLKRTSVAGTP
                     PPAAGADTGTRARVL"
     aSDomain        12099..12764
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B061_RS37445_TauD.1"
                     /evalue="2.00E-14"
                     /label="B061_RS37445_TauD.1"
                     /locus_tag="B061_RS37445"
                     /protein_end="275"
                     /protein_start="53"
                     /score="45.9"
                     /tool="antismash"
                     /translation="RRQDLEEAQLALLAAYLGEVFAWPTIQRGRMVQNLIPVESDREEQ
                     SGHGSVALEWHTEDGFHQDRCRYLGLLGIRNDDRVPTTIGSVHDVRLSAHHRSVLHQRR
                     FLIRPDLEHLRQLAELDPEDEALRRARAMNENPEPAALLFGDPEAPCLRIDAPYTTSLP
                     GDDEAAEALSAVVGELSRVQRDVVVGEGDVLIVDNYRAVHGRRAFSPRFDGTDRWLKRT
                     "
     misc_feature    12960..12971
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            12974..13891
                     /locus_tag="B061_RS40390"
     CDS             12974..13891
                     /EC_number="2.5.1.10"
                     /GO_function="GO:0004337 - geranyltranstransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF045485.1"
                     /locus_tag="B061_RS40390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="farnesyl diphosphate synthase"
                     /protein_id="WP_158689995.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.4e-58, bitscore:
                     190.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFTVDNAEIEADLPVPMENFRRQVNDRLRSSVDSVEPPRLREAM
                     AYSLLADGKRIRPTLCLLTFEIFDTDVSIALPTACALEMLHTASLIHDDLPSMDNDDFR
                     RGSPSNHRVFGEGMALLAGDALLAYALEFILQNAGALPPEKILGVMAKLIEVVGPSGLS
                     GGQAIDLHSQGREQVDAWTVEEMHIKKTGALIEASVVTGAILGGASQQDIAHLVTYARN
                     LGLAYQIVDDILDETSTFEKFGKEVGQDRAAGKWTYPRVMGVEKARKRVRDLIAHGVAE
                     LDGFGERASMLRWAAQVVHDRAAA"
     misc_feature    complement(13020..13033)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.31"
                     /tool="antismash"
     misc_feature    13118..13120
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13888..14997
                     /locus_tag="B061_RS0131975"
     CDS             13888..14997
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572490.1"
                     /locus_tag="B061_RS0131975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_018515604.1"
                     /transl_table=11
                     /translation="MTHAAGSPEELETTDASAVPPNPAGANIAASWYAAIRSPRLGKGP
                     HRMRLFGRQVVLWRDRRGVAHCVAAHCPHQGADLGLGDVVDGQLRCPFHHWRFDGNGVC
                     SAIPGVERIPTTARTRSYPTQEAHGFVWVWYGTPEPLFALPEFPAKSARPRRYLGFHYD
                     DTTTGTVRQLLENAVDHQHFSALHGLALDAVEFRVLTEQSEASDNGPPLSRDDSWFGVW
                     FSGRPRRPPLRRAPFAWLTGVVSTFAMGRRMQLLVDGWPGGQRFTAYVDGTEVYKVIMG
                     IVPEGDRATRQIGWAGVRRTGRWPRTLFNYALFWVQNRAGTFQDVPVYDSTRNAQRTVY
                     VRYDNGLLRFRRYYQSWVDRVTDDGRTGT"
     gene            14994..15992
                     /locus_tag="B061_RS37455"
     CDS             14994..15992
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012575.4"
                     /locus_tag="B061_RS37455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_018515605.1"
                     /transl_table=11
                     /translation="MSLAPVRGQPPRDLEAPRGLARGWYVAERSARVGGRPRATVVAGT
                     EVVVWRAGDGAAVVMDRFCPHQGAALELGRVVDGALRCAFHHWRFDGEGTCVAAPATRR
                     VPRGASARVHPSWEGLGYVWTWVGSAVPEYPPPDFPHLERSARSGRRYRFAFETNATAR
                     RVLENGFDLPHFPVVHGIAGDLRLTWDAEEDKHTIGARIITDSITLPPPLDRAPGLGRL
                     CLHLRSTPSYQVLTFELDDRPMAHELLAVTPTAEGATTMHGWTVMPRTGGLLGSAPAFW
                     AYRLQHWWGTRADLRIYRDAEETDGSVNTSDDEGVLRFRQFHRGWTGRVTE"
     gene            16039..17061
                     /locus_tag="B061_RS0131985"
     CDS             16039..17061
                     /GO_function="GO:0051537 - 2 iron, 2 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537305.1"
                     /locus_tag="B061_RS0131985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Rieske 2Fe-2S domain-containing protein"
                     /protein_id="WP_018515606.1"
                     /transl_table=11
                     /translation="MRQKTSERLAAAARPVSNLASGWYVALPSAELRGRPRKATLFGRG
                     HVVWRGADGRAHVQGAVCPHAGAALYGGKVVDGTLECPFHRWRFDGSGTCVSVPGRVPP
                     RRAAVATLPTRESSGFVWVWYGKGAPRYEPPDLPGLRARRLPSTRNFRLADPTRATTRR
                     ILENTYDPDHLVALHGLTVTGDARITFPPADGLPEERCDATLTWPSYRGPLGAVSNVFG
                     LNADEFTLRLRGWASCQEIEYYADGRRLYRMVLAVTPIGEHHSVQHISAAVDADGAGVM
                     GRLRSLVHRAEVQVAARQDLPVFDTLLPGDRHGIYVPGDEAVRRFRRFYQQWVELAQRG
                     "
     gene            17054..19420
                     /locus_tag="B061_RS0131990"
     CDS             17054..19420
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.4"
                     /locus_tag="B061_RS0131990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_018515607.1"
                     /sec_met_domain="PPDK_N (E-value: 6.4e-34, bitscore: 112.0,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAERVVSLAEAAGLPVEQVGGKAKGLGRLVAAGFPVPPGFCLPVG
                     VFAASAGREEDGGPGLLPDAVAEVRAHWEALHAPHGVAVRSSATSEDGAVSSAAGQYES
                     ILGVRTFEELLAALGRCQRSRHSAAAGVYRDRIGLTDGAPAMAVVVQAMLDPTWAGVLF
                     TAEGPAAEDGHLVLVEAVEGLGTGLVDGVVEPERAVFSRSEPHAPAFSTAFGERMGGTE
                     GREGPLRSLVRTALAVEKALGAPQDIEWALDGAGVHLLQARPITAAVPLPTRFGDWAAE
                     VPGTRWARMSICDSWLSDPLSPLFATTLFPTLIDRWATNWGGPAGQRARNPLIPEPMHG
                     TVNGFAYLRFDFPLSRHPLRTLRLTARWLGFHLSPVERRWREEVLPALRDGLERVRDTP
                     LADLSSAEVLRRIRTVEELSARYWAVIGGLAWHWNAGEWLLGKVLARGGRRTAGLTAGA
                     LLVGEDRLAHQADRALDRIAAAPEDEERLLDAYLRRFGHLVYSLDPAEPTAIDDPSMLR
                     SVIAGRRRDGTGGPGGPPVPGSGAAGPARRLGRGPLGQVRHRVHRWANHWSGVRDEALH
                     HFTLGWPFMRAGYLELGRRLVGAGLLDTDDDVFYLTGEELSGWVGTATGDARWRDLVHR
                     RRLRRQWQRRLDPPDVVPADARIVLFGSDITSLALFGVERQEDRADGLSGSAVSPGSYT
                     GRARVIQEITEADTLEKGEVLVVRQVTPAWAPLLARAGAVVADVGGALSHGSVVAREYG
                     IPAVMGVRTATSRITSGTLLTVNGDAGTVQLRVEP"
     gene            19417..20385
                     /locus_tag="B061_RS0131995"
     CDS             19417..20385
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015651.4"
                     /locus_tag="B061_RS0131995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysylphosphatidylglycerol synthase transmembrane
                     domain-containing protein"
                     /protein_id="WP_018515608.1"
                     /transl_table=11
                     /translation="MTTPHSPPKRRTTRTRVIRVLLFVAVAVSLVITLRGLDPGHLWAV
                     VTDADPRWLTLAVLANVASQVTRALGWNAMFTGSRIRLGLLVRIEFAVQAAAAVSPEGV
                     GEFVRVGYLLREGVARTVTVTLMLVRKFFSSLGLVPFLVVIWWPGSGMPGWAVAVAWAY
                     LAVLTVESLLIVRVARTPSAPAREGRLRQIVFDARTSLGPVRRPRVFAEVGAAGLVTRA
                     LDLVAAAAVAKALGLGLSAAVLVLVLLSVEVSNIMPTLPGQVGTFEAAVLAATAGVLGQ
                     AEGLAFALVFHAQQVLPQIPLGMMTMAGRSLLPNRSKQDPT"
     gene            20382..20849
                     /locus_tag="B061_RS37460"
     CDS             20382..20849
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608988.1"
                     /locus_tag="B061_RS37460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018515609.1"
                     /transl_table=11
                     /translation="MTEPWNADTPKVIQLPSGRRIRGRGLRYDLPEGQTPTFAVHLTDH
                     RPADQPWESVWVPWRDFWLPADPAEAMAKLRLAYERASSERVEICCGGGIGRTGTALSA
                     ICVFEGMDPKEAVKWVRKNYHSRAVEVPWQRRFIRQTFAADASGGGRADHS"
     gene            20972..21418
                     /locus_tag="B061_RS0132005"
     CDS             20972..21418
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961317.1"
                     /locus_tag="B061_RS0132005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018515610.1"
                     /transl_table=11
                     /translation="MEARDHEIEKELAATLQARRELGPEYESALVDSFLEKVEQRLDTT
                     LDRQVRRHLAEQQVTAARDPRSISPPSAGALSGFGERFGFGVVSLVLAVPLSAIGVANA
                     GIEGLVVAWMGIVGVNVAHAARGGGLFRQRGRERRAAPASEWQD"
     gene            complement(21829..23235)
                     /locus_tag="B061_RS0132010"
     CDS             complement(21829..23235)
                     /EC_number="4.2.1.22"
                     /GO_function="GO:0004122 - cystathionine beta-synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019344 - cysteine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515611.1"
                     /locus_tag="B061_RS0132010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cystathionine beta-synthase"
                     /protein_id="WP_018515611.1"
                     /sec_met_domain="PALP (E-value: 2.2e-72, bitscore: 238.3,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFHDSLITLVGNTPLVRLRNVTAGIQATVLAKVEYFNPGGSVKD
                     RIALRMIEAAEQSGELKPGGTIIEPTSGNTGVGLAIVAQQKGYKCIFVCPDKVSTDKIN
                     VLRAYGAEVVVCPSAVDPEHPDSYYNVSDRLVAETPGSWKPDQYSNPNNPRSHYETTGP
                     ELWEQTEGKITHFVAGVGTGGTITGTGRYLKEISKGAVQVIGTDPEGSVYSGGSGRPYL
                     VEGVGEDFWPSAYDAEVTDEIVAVSDKDTFQMTRRLAKEEGLLVGGSCGMAVVGALEVA
                     KRLGPDDVVVVLLPDSGRGYLSKIFNDEWMADYGFLEDTSSSPQVSAVLNFKEGPLPSL
                     VHMHPDETVGQAIDVLREYGVSQMPIVKPGAGHPDVMAAEVIGSVVERQLLDALFTQRA
                     SLSDPLEKHMSAPLPQVGSGEPVEDLMAALSGADGADAAIVLVEGKPKGVVSRQDVLAF
                     LAKDAGSAKV"
ORIGIN
        1 acggcggcga aggtctcgta ggtgccctgg aggatgccct gggtgccgat gtagatccag
       61 gacccggcgg tcatctggcc gtacatggtg aggccgagcg cctccaggcg gcggaactcc
      121 tcccagttgg cccagtcgcc gaccaggttg gagttggcga tcaggacgcg cggcgcccac
      181 tcgtgggtct gcatgacacc gaccggccgc cccgactgga cgagcatcgt ctcgtcctgc
      241 ttgagcgtct ggagggtccg gaccatcgcg tcgaacgagc gccagtcgcg ggccgccttg
      301 ccggtgccgc cgtagacgac gagcttgtcg gggtgctcgg cgacctcggg gtccaggttg
      361 ttctggagca tgcgcagggc ggcttcctgc tgccatccca gggtgctgag ggcgctgccg
      421 cgcggcgctc gtacggggcg gggtcctgac atggcggtgc ctcctcggga cggtgaacat
      481 ctattcacat cctgaggcgc tgaatagtcg tagtcaacag gtgcggttcg cgtcgcgccc
      541 gggaagtggt gttccatccc cgacccgagg gcaccggagg caccgatgag cacgcccggc
      601 acaccagaca cgcccggcac acccgcaccc gcggcccccg aggcgtcgcc gccgctcaag
      661 cgggcgctcg gccccaagct gctgatcctc ttcgtcatcg gggacatcct cggcaccggt
      721 atctacgcca ccaccggtga tgtggcgggc aaggtgggcg gggcgctctg gctgccgttc
      781 gcgatcgggt tcgtcgtggc gctgctgacg gcggcctcgt acgtggagct cgtcggcaag
      841 tacccgaagg cggccggggc cgcgctctac acccagaagg cgttcaggat cccgttcctg
      901 accttcatcg tcgccttcat ggtcatgtgc tccgggctct cctcggcgag cgcggcggcc
      961 cgggcgttca gcggcgacta cctgggcgag ttcaccgacg ccgtaccgcc gaccctcatc
     1021 gcgatcctct tcatcctcgc gctggccgcg atcaacctgc gcggggtctc cgagtcggtg
     1081 aaggcgaacg tcgtgctgac cctggtggag gtcagcgggc tcgcggtgat cctggggatc
     1141 ggcgcgtacg cggtgttcag cggcgacgga gagccctccc ggctgaccca gatcgagacc
     1201 ggaggcaccg gatacgccct gctcaccggg gtcctcggcg ccaccgcgct cggcttcttc
     1261 gccttcgtgg gctttgaaga ttcggtgaac atggccgagg agaccaagga ccccgcccgc
     1321 aacttcccgc gcgccatctt catcggcgtg gccgtcaccg gcacgatcta catcctggtc
     1381 gcgctggtct cctcgctcct ggtcgactcc cgcaccctgt ccgagtccag cggcccactg
     1441 ctggaagtgg tgaaggcggg cggcgtcgat tttccgccga aactcttcgc gctgatcgcc
     1501 ctgttcgcag tcaccaactc ggcgctgatc aacctgatga tggcctcgcg gctctgctac
     1561 ggcatggcca acgaacgcat cctcccgccc accatgggca aggtgctggc gggccggcgc
     1621 accccctggg tcggcatcgt cttcgtctcc ctcctggcga tcggcctggt ctccaccggc
     1681 gagatcgagg ggctcggcga caccacctcg ttcctgctgc tgtgcgtctt cggcgtggtc
     1741 aacatcgccg tactggtgct gcgcaaggac cgcgtggacc accgccactt ccgtacgccg
     1801 accgccctgc cggtcctcgg cgcgatcacc tcgctggtcc tggcgagccc gctcgccgac
     1861 cggggcgccg acgtctacgt acgggccggg atcctgctgc tgatcgggat cgggctgtgg
     1921 gcggtgaaca aggcggtgat ggcggcccgc gagaagtccg accgggcggc ggactgacgg
     1981 gacgtcaccc cggttcccgg ccaccacatt tcagccgctc ctttacaccc tggggcgcat
     2041 gtaccaaagg aaaatgccag aacctccacc tgccgtgagt acgttgcgta gcctcagggt
     2101 cacagccgta cgccgcgtcg ggaggggaat ccgcgtgccc ggaatcgacg agtgcctgct
     2161 cgaagtcatg aggctgcccg gcgcccgggg cgcctcggtg gtcgactgga cgagcggcct
     2221 cgcgctcggc accatcggcg agtcccccaa cggcgaccac gaggcgacgg cggccgagac
     2281 cgccgaggtc gcccggatga ccgccgaaca gcccgccttc gcccacctga ccgcaggggg
     2341 cggaagcgaa cgctccgggg aagcgccgag cacctccgtc gaggacgtca tcgtcaccac
     2401 acaagacggt taccacatgc tccgcttcgt cgagacggct ttcgacagca gcgtcttcct
     2461 ccacctctgg ctgagccgct ccgagggcaa tctcgcgatg gcccggttac gcctgggtga
     2521 gctggccgag cggctggtgc tggcatgagc gcgatagccg ccgaccccgg cgccccggag
     2581 acggaccggc tcccggtcct ctccccgatg ctccagcgcc tcgccgccga acgggccacc
     2641 ggcgccctga tgcgcgaccg cggcacgctc tacctcgccg acggccaggt ggtgcacgcc
     2701 gagagccccg ccacccccgg catcgacgtc ctcctcacca ccggcggcac actgcggcac
     2761 gagggctggt gggacgcggt ggcgcaggcc ggggcgggga ggcgggtcgg ccgctatctc
     2821 gtggacagcg gccatgtacc gggcggggcc ctggagttgt gccacctggg cgccctgtac
     2881 gacgccgcgt tcttcgccct cgccccgacc gggacacccg cccgcttccg ttacggggtg
     2941 tcccactgga tcgggccggt gcggccggtc ccggtggccg ccgtccagcg cgagacgctg
     3001 cgcagacggg agctgctgga ccggatctgg cccgacgccg cctgcgacag cgccccggtc
     3061 gtccgggcgg cggcacaccc gggcgacagc cccgtacccg cccgccagcg cgccgtcctg
     3121 gagctggccg acggtgtgcg tacggcgtcg gacatcgccc tggcactggg ccgttcggcg
     3181 ttccacatcc tggtcgacct gcggcggctc gccgcggccg gccaggtgga ggcggtccgc
     3241 gcgcagcccc tgcccgccac cgcctcggca cacggccgga tcacgctccc cgaggtgacg
     3301 gccgaccccg atatcgccct gctgcgccgg ctccgagacg cattggaggc cctgtgatac
     3361 gcgcgctcag acagcgtgcc gggaggagac agctgatggt tcccgaggcc gagacgcgcg
     3421 gtgtcctcga cgagctccag cggttacggg ccagggtccc cctcctcgcc ggggcgctgg
     3481 ccgcctccac cgacggactg gtcctggccc acgacacccc gggcatcgag gccgagggcg
     3541 tcgccgcgct caccgccgcc gcgctcggcg tctcgatccg gatgacggag gccaccggcc
     3601 gcggcggctt ccgggagctc ctggtccgcg gcgagagcgg ctacatcgcc acctacgccg
     3661 ccggctcgtc ggccgtcctg accctgctgg ccgaggaccg catcaacgtc ggccggctcc
     3721 atctggaggg ccgccgggca ggcgcccgga tcggcgaact cgtcgacacc gccctggaac
     3781 gcgccgagcg cacgcccccc atgccgcgca ccgcaccgtc gcgcggcgcc cccaaccgca
     3841 cgctcccgca gcgccccacg taaccacccc tcccccacgc gcaccacaac cacccaccac
     3901 acaccacacc catgccactc acgcgaaaac ggacccggtc agcgcgaccg gccacggaaa
     3961 ggaaacgagc ctccatggcg aacaccgaag cgtcactgaa ggaagcgatg agctcgatcg
     4021 agggcaccac gggtgtcgcc ctcgtcgact acacgagcgg tatggccctg ggcacgctcg
     4081 gcggcggcaa ggacttcaac ctggaggtcg cggccgcggg caacaccgac gtgatccgcg
     4141 ccaagctccg caccatggag cacctgggca tcaaggagga gatcgaggac atcctcatca
     4201 ccctgggcac ccagtaccac ctgatccggc tgctcaagac ccggggcagc aacggcctct
     4261 tcctctacct ggtgctggac gcgagccgag cgaacctggc gatggcccgt caccagctga
     4321 agaagatcga ggccgagctg gaggtctgag gcctgaaagg tcggacctct tgcggtgcgg
     4381 tttcgacgcg caaaggtccg acctcaccgg cggcgacgac gcaaaggtcc gacctcaccg
     4441 gcggcgacga cgcaaaggtc cgaccttacc ggcggtggcg ccgctgaggt ccgaccttta
     4501 ccggcggcga cgccgcgccc ctcccggcgc ggcgtccccc gctaccggcc ccgtcgtgcg
     4561 gtgcccctgc acccccttcg cgaccgggct gccgcgcccg gcccagtcgg tgcggaccca
     4621 gtacaggacg tcgtcccggc gctcccgctg cccgatccgc accgccttgg cccagagacc
     4681 ggcccccgcg cccgcgagca ccagaccgcc ggcgcccggc agtgcgaacg aggacgccac
     4741 cgccgccacg aacgcgccca gcagccacca ccggtgcccg cgccgccaca cccgtacggt
     4801 cacggcccgg tcctggagga agtcgccgcg ccccgtcctg gaggcgcccc gcgccagctc
     4861 cgcgtaccgc ccgccgcgcg ccaggagcac gaaggccgcg gtcacgatga agagcgccgc
     4921 ccccgtcagc agcccgatcc ggcgcccggt cagccccggt acgaacgctc ccgcggcggc
     4981 ggccaccagc ccggcccacc acagcggggc ggccccggcc cgtacgatca cggccactct
     5041 cgccagcgac tgtcctccgc gccccacgtc cgtacccctc tcgctccacg cccgccggtt
     5101 cctgtgccgg tcgttccggt cgttctgcgc gcggagatta gcggccgcag atgaggggtg
     5161 cgtgagaatc cgcgaaatcg agccgctcag aaggcctcac tccacgaaca ggccccgggc
     5221 agccgcccgt acgtcgaact cctccagccg cgcctgggcg tcgggcagtt cgtcgcacat
     5281 cgcctccagc agcacccgcc ccagcagcat cggggcgcag acggtgtcga aggagagccc
     5341 ggagccgatg gccgccggga ggagcagatc gctgtgcttg gcgaccggtg cgaaggcgga
     5401 gtccgcgacc gtcacgacgg tgagcccctg ctccccggcg tacgccagcg cctccacgga
     5461 ctccctgggg tggcgcggca gcgcgaagca catcagggcg gtggcgccgg cccggcgggc
     5521 ggcgtcgatc cggtccagga gcatggagcc gccctcgtcg aggacgcgga cgtcggggtg
     5581 caccttggcg gcgaagtagc cgaaaccgcg cgcctgcgag gaggccgcgc gcagccccag
     5641 cacgggcagc ggccgggact cggccagcag ccggcccgcc cgctccacgg gtccggggtc
     5701 ggcgaggagg tccgagaggt gctggaggtt ctcgatctcg gcgcggacgg cctgctggta
     5761 ctcgttgtac gtctcccccg cgtcctcctg ctccgcgtcg gcgggcgcga cctcgcggag
     5821 gtggcggcgg agcgccgggt agccgtcgaa gccgagggcg acggcgaacc gggtgacgga
     5881 gggctggctg accccggcga gctcggccag ctcgacgctg gagaggaacg gcgcgtcggc
     5941 cgcccggcgg accatgcagt gcgcgatgcg ccgctgggtg ggcgtgagcc ggtgcccctc
     6001 gaagagctgc tgcaaccgcg cggcggggct gctcccactc atgctgtccc cttgctgatc
     6061 ctcgccggat ccctcgcgcc acgatcggcg tcgcgccacg gtcggcgccg acagatccat
     6121 tcagccagga aggctcctgc atgtccatat gcagcgggcg gccgggctgc ccccggtcag
     6181 atacggaccg gcaggcgggc cgggccccgc aagctcagca ggccgttcca gcggacctcg
     6241 cccgcctgct ccaggtccgg aaaacggcgg accagttccc cgatggctat ccgcccttgg
     6301 atccgggcga gccctccacc gatgcagtag tgggcgccgc cgccgaagga gacgtggcgg
     6361 cgcgcgttct cgcggtccag ccgcagccgg ccggcgtccg ggccccagaa ctcctcgtcg
     6421 cggttggcac ccgccaggct cgcgaggacg accgaaccgg ccgggatggc gagctccgcc
     6481 atcagcaggg ggtgcagggt gatccgccgg gcgaggtgga ccgggggttc gtagcggagc
     6541 agctcctcga tcgcgttccg ctccagtccg ggtgtggtgc gcaggaggtc cagctgctcg
     6601 gggtggcgca gcagcgccag gatccccccg gagatcaggt tgacggtcgt ctcgtaaccg
     6661 gcgacgtaga ccatggccac ctgggcgacg agttcgtcgt gggtgagccg gtcgccgtcg
     6721 tcctcggcgt cgatgagggc ggtgaggagg tcgtccccgc gggcccggcg cttgcgggag
     6781 atcgcgtcgg agacgagctc cgccatctcg gcgtcggcgg cttcgatgcc gtctttcgcc
     6841 ccggagccgg cgccgggttc ccccagccgt atgagcaggc tggtcagctc gcgcaggcgc
     6901 accgtgtcga cctccggcat cccgaggatc cgggtgatca cggcgaacgg cagcggaaag
     6961 gccagggctt cgaccaggtc cccgcccccg gcgcggccca gctcctccaa cgcctcgtcg
     7021 accagggccc gcaccaccgg ctcgatcccg ctcatcgccc tgggggtgaa ggcctgggag
     7081 acgagtctgc gcaggcgcgt gtggtgcggg gggtcctggt cgatcagtgc gagccccttg
     7141 aggcgcggcg ggcggccgga atcggtggcg ccgcgcgcgc tgcgcttgtc gacggagtgc
     7201 tccccgcgca gcagcgtctc cacgtcctcg taccgggaga ccatccagaa gccgcccggg
     7261 tgttcgtgca ccggggcgtg ccggcgcacc tccgcgtagt gagggtgcgg gtcctccatg
     7321 aatccctcgg acagcgggtt gaacatgatc ggggtccggc tcgtcgcgcc gctcatgacg
     7381 cacgtcctct cttcgggtgc aggggtaaca ggtgcagggg tgaacggatg ggcagcggcg
     7441 aggaccgggg ccgcccgcgc cggtgcgccg ccgcggcgag caccccggcg gtcagggccg
     7501 cgcaggcgac gacgcccttc cgcaggtacg tgcccggggg ccgggcgggc ggcgcgggga
     7561 ccgggcgggc ggtgaccacc cgggggtacg gctccagcgc cgccgcgtag cggggccggc
     7621 agacctccgc gatacgggcc cgccgctcgg gcggcagcgc ggacaggcgc tccaggaaca
     7681 tcgactcgta ccggtccgcc tcgcgccgga gctccgtggc ggccgcgtca ccgtagagct
     7741 ccacgaaggc ggcgtacacg ttcaaggtgc ccgcggcgac gtcctgttcg tagtgccgca
     7801 ggtcgttcgc caggtccgcg agcacttcca ccggccagag caggtcccgg gtcgcgggct
     7861 ccatcggacg cccccgcagg gcgaaggcca tcgcgcgcag cagacgtacg tcggtgggcc
     7921 gcagttcgac catggcgagg acgtcgcccc gggtgacggt cccgcgcgag gtggcgccgt
     7981 tctccagccg gacgaaccgt tccgcctcgt cgaccaggaa ggccacgtcc ccgttccacg
     8041 cgcccagcgc ccgcagcacc ttctcgaagg ccttcttgta ggtgtggaac gcctcgtagt
     8101 cgtcgttgcg tacggcgtcg aggtccaccg tcgcgttccg ttcggccagg gagtcgacgc
     8161 ggtagacgag gtactcgacg cccagcagca ggggtgtcag ccgcaggcga tccaggcgcg
     8221 gcacctcgtc cacctcgtag tacatccgca ggacgtagtc ccgcacgatg gctgcggcct
     8281 tccccagagg ggtggcggcc aggacggccg gactgttcat cacacttcct ttccacgggc
     8341 tccggacttt ccaagggctc aggactttcc acgggccccg gactttcccc gggccccgga
     8401 ggtgcctggg cgcggggcga cggcgagacc gaccgtgagt cccagcagcc agccgcccac
     8461 gacgtcggcg gggtgatggg cgtcggcgac gacccgggtg acgccgacgg ccaggacgag
     8521 gagcgccccc gcgcccagcc acgtccacca cagcggtgtg ccggtacgcg ccctggccac
     8581 cgccaccagc accacgacgg ccaaggtcgc ggaggccgcg tggccggacg ggaagctgaa
     8641 cccggcgtcg ggcggtgtgc cgtcggccgg taccggcgac gcccgcccca ccaggggtcc
     8701 gagcaccgtc tcggcgacga actgcgcggt caggccgccg agcagccaca gggcggcgcc
     8761 gaaccggcgg cggaccagca gcaccccgag ggccgccacc acgagcacgg ccagcagggt
     8821 ggagccggcc aggtcggccc gtccgccggc cccgggccag gggccggcgg acgggccgaa
     8881 cgcccgggcg gcgagcgccc gggctccggc gtcgaacgcg ccgacggcat cgctcccggc
     8941 ggccaccagc acggccagca cggtgagcgc cgccgccgag agcgccgatc cgacgagaag
     9001 ccggggggcg gtccgggctc cggcgccggt cacctcgtgg gctcggcggg ggtgtggccg
     9061 ggcgcgaccg cgtcgccggg ggtgcccgtc ggctccgcgg gcttcctggc cgtgaccacc
     9121 tggtagcgcc aggctccggc atcgaacatc cggatctgcg cggcggacgc gatcaggttg
     9181 tcggcgggca ccggggccag caccccgagc cgccggaagg cgggcgcggt gggacccagc
     9241 agccggacca gccaccgcag ccggtgcagg gagggggcga cgtaggggga gatgtccacg
     9301 atccgtacgt cctcgaagcc ctgcttgtgc agcagccgct cgtactcgcc ggcggtgagc
     9361 agtccgggca tcgcccaccc ccggcaccag gtcgccagct cctcctcctg cgccggggtg
     9421 ggtgccgggt cctcgcggac gaggtactcg gcgatcatca gccgtccgcc gggagccagc
     9481 acccggtgcg cctcacggac gaaggcctcc ttgtcgtcga cgtggacgac gctctccagc
     9541 gcccagacga cggtgtgcga cgcgtcgggg aggccggtgt cggtgaagtc ggcctcgacg
     9601 aactccacga ggccgtcgac gcccgcccgg tgggcggcct cccgggcggc ggtgacctgg
     9661 aacggtgtga tgttgacgcc ggtggcacgg cagccgaagt ggtcggcgat gcggatcgcg
     9721 cagcccccga tcccgcatcc ggcgtccatg atccggtcct cgggagtgat cccgacgacg
     9781 gacgccagat agccggtcat ccggcgcagc gccgtgacgt ggttccggat ccggcggtcg
     9841 tagaagccga agtggagggc tccggccttc tcgctgcgcc acagatggcg gtagtcccag
     9901 cgggttccct cgaagtagtc gacgacctgt tggcggttgg cgctcatgtc cattcccttc
     9961 ctgccgtccg gcggacggcg tccgtgacgg agcggagacc tcagaacctc tgccagggcg
    10021 acatgcccgc ggccctgata cggcggtgga gcaggacgca gtaggcggcg tcgagcagga
    10081 acgtccaccc gtacatgacg ttgatcagcg gggtgagcgg gtaggaacgg ttgcccagcg
    10141 cctggcgtgt gaagtcggac cagctcgtcg gccaggtccg ctgcggggtg gtggtgacgg
    10201 tgagcgccgt ggcgatccag gcgcacaggg tgccgagcca cttgccgacc gcgatgtaca
    10261 tggactgccc cgagggcgac ccgcggtcct ccagcatctt gatgtacagg atcgacatca
    10321 tgaggttgat cccgaacccg gtgtactccc cgtcggggtc cgccaggtcg atgaacgcgt
    10381 ggtagttgac cgacagggcg gcggccacgc agagtccgaa aatagggcgg aagtaccggc
    10441 ccagggagct gtcggggaac tgtgccgccc cgtacttcca cacctgccag gcgatcacgg
    10501 cgtcgaccag gaacccgaag atgctggccg tgtggaagta gtcgcccagc gggtccagga
    10561 ggaagccgta ggcgaactcc caggtgaggt tggcgaagag ggcggcgagg ggcacaccgt
    10621 aggtctggtc ggcgaagccc cggtagatga tcgccgcgta ggcgaccagc cagccgacca
    10681 cgcacagcat gccgaacagg acgaccgcgc tcgacacccc ctccgccgtg gtctcctcct
    10741 cgtgccgttc ggccgcgggg tccggatagt cgccccaggc gggagcgcag tggagcgtga
    10801 ccgcgtgtaa cagccggtcg cgttcggcga cgtcgagtgc ctgcacccgc ttctcgaact
    10861 gccctcggaa atcggccact tcctcgcgca gtcgctccgc cgccgtgtcc ccgtaggtgt
    10921 cgacgaaggc ggcgtagata ttggtgcgtc cgaccgtgcc ggtgccgttc gcgtactgcg
    10981 tcaggtccca ggcgacgtag gcgagggtct cggccggccg gagcgcctcg cggagctccg
    11041 cgtcgccggg gcggtcccac acccggccga cgtcacggac gacgcgcagc tcgctgggtg
    11101 ccagttccat gagccggcgc agctgtccgg attcggcccc gccccggcgg acctggaatt
    11161 ccgtttcggc gaggtcagcg atgtcctgct gggctcgcgc cccatcggga atgttggcgc
    11221 aaatacgcgc cagcgtccta tcgatgcagg cgtctcggaa cacgatgaga tgtccgaata
    11281 gattgcctcc gaccggctct ggggcgagcg ctccgagtcg gcctcgtttc atggcgaatg
    11341 ccaggtatcg cgctgtcagt cgcgatggtg tggcgcgaag ttgccctttc agggatgccc
    11401 cgagcaccgg gccgtggata ccctccccga cggcgatctc ggtggcgcgc cgtatcgccg
    11461 gggtcacctg cgtgacgacc gaggtcagga gctgcctggc acgtcgggac gcggtcagcc
    11521 tcagggttct catgctgttc attcccgtct cctagagcgg aatcccgcac agcgcacccg
    11581 atccgcggtc acacggcgga cacacaaccg ccttaacgga atcgggagtt caggttgcga
    11641 caacctgaac agatgacgaa catggtgtac cataatgatc cgcgccgccc agagttacag
    11701 aagacttacc ggactcaccc gcaagacctg acgtacaggt tcgccaccga ttcgtcacca
    11761 ggcatcatcc gtacgggttt ctcaccgata tggttgccgt ccggaccacg ggggtttaca
    11821 taatggatac cgttttaggg cacttactca cgggtgaaga ggccgaggca ttacgcgcgg
    11881 cagcccggac agcactgaac agccaaggct cacccgccga tcccaccttc tacaagggat
    11941 tggacgacca tctccaccgc ataccgggat cgctccgcgc ggccctggac gaattgcggg
    12001 aatccccctc gctgagcgca ctgcgcatct cgggggcgcg tgtcgaaccc gagcggtgcg
    12061 gacccacccc gctcacctgg caggaagccc tcgacgaccg ccgccaggat ctggaggagg
    12121 cccaactggc gctcctcgcc gcctacctgg gtgaggtctt cgcctggccg accatccagc
    12181 ggggccggat ggtgcagaac ctgatccccg tcgagagcga ccgggaggag cagagcggcc
    12241 atggctcggt cgccctggag tggcacaccg aggacggctt ccaccaggac cggtgccgct
    12301 atctgggcct cctcggcatc aggaacgacg accgggtgcc caccaccatc ggcagcgtgc
    12361 acgacgtacg gctctccgcg caccaccggt ccgtgctcca ccagcggcgc ttcctgatcc
    12421 gcccggacct ggaacatctg cgtcaactgg ccgagctcga ccccgaggac gaggcgctgc
    12481 ggcgggcccg cgcgatgaac gagaacccgg agccggccgc cctcctcttc ggcgatcccg
    12541 aggctccctg cctgcggatc gacgcgccct acacgacctc actgcccggc gacgacgagg
    12601 cggccgaggc cctgtccgcg gtcgtcggcg agctgagccg cgtccagcgg gacgtggtgg
    12661 tcggcgaggg cgacgtactg atcgtggaca actaccgcgc tgtgcacggt cggcgcgcct
    12721 tcagtccccg gttcgacggt acggaccgct ggctgaagcg gacgagcgtg gccgggaccc
    12781 cgccgcccgc cgcgggagcg gacaccggca cccgggcgcg ggtgctctga ataccggtcc
    12841 gccgaccgct ctccgggccg gctcccggga aagccgcggc cacccttcgg caccgcgccg
    12901 tgaaccaccg ccatcagcgc cacccggtcc atcgatgact cgttcagcga atccatgggg
    12961 ggaatgaacg ctcgtgtcct tcaccgtcga caacgccgaa atagaagccg atcttccggt
    13021 tcctatggaa aatttccgcc gccaggtgaa cgacaggctg cgctcctccg tggattcggt
    13081 ggaaccgccc cggttgcgcg aggcgatggc ctattcgtta ctggccgacg gaaagcgcat
    13141 ccggccgact ctgtgtctgc tgacgttcga gatattcgac accgatgtct cgatcgccct
    13201 ccccaccgcc tgcgccctgg aaatgctgca caccgcctcc ctcatccatg acgacctgcc
    13261 gtccatggac aatgacgatt tccgccgggg cagcccttcc aatcaccggg tattcggcga
    13321 aggcatggcc ctgctggcag gtgacgcact gctcgcctac gcactggagt tcatcctcca
    13381 gaacgccggg gcactgcccc cggagaagat cctgggcgtc atggccaaac tgatcgaggt
    13441 ggtcggcccg tccggtctct ccggcggcca ggcgatcgac ctccactccc agggacgcga
    13501 gcaggtcgac gcgtggaccg tggaggagat gcacatcaag aagaccgggg cgctcatcga
    13561 ggcctcggtg gtcaccgggg ccatactcgg cggggcttcg cagcaggaca tcgcccatct
    13621 cgtcacctat gcgagaaacc tcggactcgc ctaccagatc gtcgacgaca ttctcgacga
    13681 gacgtcgact ttcgagaagt tcggcaagga ggtcggccag gaccgggccg ccgggaaatg
    13741 gacctacccc cgggtgatgg gagtggagaa ggcgcgcaag cgggtccgcg acctgatcgc
    13801 gcacggcgtg gcggagctcg acgggttcgg cgagcgcgcc tcgatgctcc gctgggccgc
    13861 ccaggtcgtc cacgaccggg ccgcggcgtg acccacgcgg cgggctcccc ggaggagctg
    13921 gagaccacgg acgcctcggc cgtcccgccg aacccggccg gcgcgaacat cgccgcctcc
    13981 tggtacgccg cgatcaggag cccgcgcctg ggcaaggggc cgcacaggat gcgactgttc
    14041 gggcgccagg tggtgctctg gcgcgaccgg cggggggtgg cgcactgcgt cgccgcgcac
    14101 tgcccgcacc agggcgccga cctcggtctc ggggacgtcg tcgacgggca gctgcgctgc
    14161 cccttccacc actggcggtt cgacgggaac ggggtctgct ccgccatccc cggggtcgag
    14221 cgcatcccga cgaccgcccg gacccggtcc taccccaccc aggaggccca cgggttcgtc
    14281 tgggtctggt acgggacccc cgaacccctc ttcgccctgc cggagttccc ggcgaagtcc
    14341 gccaggcccc gccgctatct cggcttccac tacgacgaca cgacgaccgg caccgtccgg
    14401 cagctgctgg agaacgccgt cgaccaccag cacttcagcg cgctgcacgg actggccctg
    14461 gacgcggtgg agttccgcgt cctgaccgag cagtccgaag cctcggacaa cggccctccg
    14521 ctgtcccggg acgactcctg gttcggtgtg tggttctccg gccggccgcg gcggccgccg
    14581 ctgcgccgcg cgcccttcgc ctggctcacc ggcgtcgtct ccaccttcgc gatgggccgc
    14641 cgcatgcagc tgctggtcga cgggtggccg ggcggacagc ggttcactgc gtacgtggac
    14701 ggcaccgagg tctacaaggt gatcatgggg atcgtccccg agggcgaccg ggccacgcgg
    14761 cagatcggct gggcaggggt acgccgtacc ggacgctggc cccgcacgct cttcaactac
    14821 gccctgttct gggtccagaa cagggccggg accttccagg acgtgcccgt ctacgactcg
    14881 acccgcaacg cccagcgcac ggtctacgtg cgctacgaca acgggctgct ccggttccgc
    14941 cgctactacc agtcgtgggt cgaccgggtg acggacgacg gaaggacggg cacatgagtc
    15001 tcgcgccggt acgcggacag ccgccccgcg acctcgaagc accccgcggc ctggcgcgcg
    15061 ggtggtacgt cgccgagcgc tccgcccggg tggggggccg gccccgggcc acggtcgtgg
    15121 ccgggaccga agtggtggtg tggcgcgcgg gcgacggcgc ggccgtggtc atggaccgct
    15181 tctgccccca tcagggagcc gcactggagc tgggacgggt ggtggacggc gcgctgcgct
    15241 gcgcgttcca ccactggcgg ttcgacggcg agggaacgtg cgtggccgcc cccgcgaccc
    15301 ggcgggtgcc ccgcggcgcc tcggcacggg tgcacccgtc ctgggagggg ctcggctacg
    15361 tctggacgtg ggtgggatcg gcggtcccgg agtacccccc gccggacttc ccccacctgg
    15421 agcgatccgc gcggtccggc cggcgctacc ggttcgcctt cgagacgaac gcgaccgcgc
    15481 gccgggtgct ggagaacggc ttcgacctgc cccacttccc ggtggtccac gggatcgccg
    15541 gcgatctgcg gctcacctgg gacgccgagg aggacaagca cacgatcggg gcccgcatca
    15601 tcacggactc gatcaccctg ccgcccccgc tggaccgggc tcctggcctg gggcggctct
    15661 gtctgcacct gcgctcgaca ccctcgtacc aggtgctgac cttcgagctg gacgaccgcc
    15721 cgatggccca cgagctgctg gccgtgacgc cgacggccga gggcgcgacg accatgcacg
    15781 gctggaccgt catgccgagg accggcggcc tgctcggctc cgccccggcc ttctgggcgt
    15841 accggctcca gcactggtgg ggaacgcgcg cggacctgcg tatctaccgg gacgccgagg
    15901 agaccgacgg atcggtcaac acctcggacg acgagggcgt gctgcggttc cgtcagttcc
    15961 atcgcggctg gacggggcgg gtcacggagt gaaggggccg acaccgcctg gacggtggac
    16021 tgtggagaag gggaccggat gaggcagaag acgtccgagc ggctggccgc ggcggcgcgg
    16081 ccggtcagca acctcgcctc gggctggtac gtcgcgctcc cctccgcgga gctgcggggc
    16141 aggccgagga aggccaccct cttcgggagg gggcacgtcg tctggcgcgg cgccgacggc
    16201 cgggcccatg tgcagggcgc ggtctgcccg cacgcgggag ccgccctgta cggcggcaag
    16261 gtggtcgacg gcacgctgga atgccccttc caccggtggc ggttcgacgg gtcggggacg
    16321 tgcgtctccg taccgggacg ggtcccgccc cggcgggcgg ccgtcgccac gctgcccacc
    16381 cgcgagtcct cgggcttcgt gtgggtctgg tacgggaagg gggcgccgcg gtacgagccg
    16441 ccggacctgc ccggtctccg ggcgcgacgg ctcccgagca cccgcaactt ccgcctggcc
    16501 gacccgacca gggccaccac ccggcggatc ctggagaaca cctacgaccc ggaccacctg
    16561 gtggccctgc acgggctcac cgtgaccggg gacgcccgca tcacgttccc gccggcggac
    16621 ggcctcccgg aggagcgctg cgacgcgacc ctgacctggc cctcgtaccg gggtcctctg
    16681 ggcgcggtgt cgaacgtgtt cgggctcaac gccgacgagt tcaccctgcg gctgcgcggc
    16741 tgggcgagct gccaggagat cgagtactac gcggacggca ggcgcctgta ccggatggtg
    16801 ctggccgtca ccccgatcgg ggagcaccac agcgtccagc acatcagcgc cgccgtggac
    16861 gccgacgggg cgggggtcat gggccggctg cgctccctgg tccaccgtgc cgaggtccag
    16921 gtggccgccc gccaggacct cccggtcttc gacacgctgc tgccgggtga ccggcacggc
    16981 atctacgtgc ccggggacga ggcggtccgg cggttccggc ggttctatca gcagtgggtg
    17041 gagttggcgc agcgtggctg agcgtgtcgt gagtctggcc gaggccgccg gactgcccgt
    17101 ggagcaggtc ggcggcaagg ccaaggggct ggggcggctg gtggcggcgg ggttccccgt
    17161 accgcccggc ttctgcctgc cggtgggggt cttcgccgcg tcggcgggcc gggaggagga
    17221 cggcgggccc gggctcctgc ccgacgccgt cgcggaggta cgggcccact gggaggccct
    17281 gcacgcgccg cacggcgtcg ccgtacggtc gtccgccacc agcgaggacg gtgcggtgag
    17341 cagcgccgcc ggccagtacg agagcatcct cggcgtccgc accttcgagg agctgctggc
    17401 cgccctcggc cggtgccaga ggtcccggca ctccgccgcc gccggggtct accgggaccg
    17461 gatcggcctc accgacggcg ccccggcgat ggccgtcgtg gtgcaggcga tgctggaccc
    17521 cacctgggcc ggagtgctgt tcacggcgga gggcccggcc gcggaggacg gccacctggt
    17581 cctcgtggag gcggtcgaag ggctcggcac cgggctcgtg gacggagtgg tcgagccgga
    17641 acgggcggtg ttctcccgga gcgagccgca cgccccggcg ttcagcaccg cgttcgggga
    17701 gcggatgggc gggacggagg ggcgcgaggg ccccctgcgc tcgctggtac ggacggcgct
    17761 ggcggtggag aaggcactgg gcgcaccgca ggacatcgag tgggcgctgg acggcgccgg
    17821 agtccacctg ttgcaggccc gcccgatcac cgccgccgtc cccctcccga cgcggttcgg
    17881 cgactgggcc gccgaggtcc cggggacgcg gtgggcccgg atgagcatct gtgactcctg
    17941 gctgtccgat ccgctctccc cgctcttcgc gaccaccctg ttcccgaccc tgatcgaccg
    18001 gtgggcgacc aactggggcg gtccggccgg acagcgggcg cggaacccgc tgatccccga
    18061 gccgatgcac gggaccgtca acgggttcgc gtacctgcgg ttcgacttcc ccctctcccg
    18121 gcaccccctg cgcaccctgc ggctcaccgc acgctggctg ggcttccacc tctcgcccgt
    18181 ggagcggcgc tggcgcgagg aggtgctgcc cgcgctccgt gacggtctgg agcgggtacg
    18241 ggacacaccg ctcgccgacc tgtcgtcggc cgaggtgctg cggcggatcc ggaccgtcga
    18301 ggagctgagc gcccgctact gggcggtgat cggagggctc gcctggcact ggaacgccgg
    18361 cgagtggctc ctggggaagg tcctggcacg cggcggccgc cgtaccgccg gactcacggc
    18421 cggggcgctg ctggtcggcg aggaccggct cgcccaccag gccgaccggg cactcgaccg
    18481 gatcgcggcg gccccggagg acgaggagcg gctgctcgac gcgtacctgc gccgcttcgg
    18541 ccacctggtg tacagcctcg acccggccga gcccacggcg atcgacgatc cctcgatgct
    18601 ccgctcggtg atagccggcc gccgccggga cggcaccggt ggaccgggcg gcccgccggt
    18661 gccgggttcc ggcgccgccg gtccggcccg ccggctcggg cgcgggccgc tgggccaggt
    18721 acggcaccgg gtccaccggt gggcgaacca ctggagcggt gtgcgggacg aggcgctgca
    18781 ccacttcacg ctgggctggc cgttcatgcg ggccggatat ctcgaactcg gccgccggct
    18841 ggtcggcgcc ggcctgctcg acaccgacga cgacgtcttc tacctgaccg gggaggagct
    18901 gtccggctgg gtgggcacgg ccacgggcga cgcgcgctgg cgcgacctgg tgcaccggcg
    18961 ccgcctgcga cgccagtggc agcggcgcct ggacccgccg gacgtggtcc ccgccgacgc
    19021 gcggatcgtg ctcttcggct cggacatcac gtccctcgcc ctgttcgggg tcgagcggca
    19081 ggaggaccgg gccgacgggc tcagcggatc ggccgtgagc ccggggagct acacgggccg
    19141 ggcccgggtg atccaggaga tcaccgaggc ggacacgctg gagaagggcg aggtgctcgt
    19201 cgtacggcag gtgacgccgg cgtgggcgcc cctgctcgcc cgggccggag cggtcgtggc
    19261 cgatgtcggg ggcgcgctgt cccacggctc ggtggtggcg cgcgagtacg gcatcccggc
    19321 ggtgatgggg gtcaggaccg cgacctcgcg catcaccagc ggaaccctgc tgaccgtgaa
    19381 cggcgacgcg ggcaccgtcc agctgcgggt ggagccgtga ccacgcccca ctccccgccg
    19441 aagcgccgca ccacccgcac ccgggtgatc cgggtgctgc tgttcgtcgc ggtggccgtc
    19501 agcctcgtga tcaccctgcg gggcctggac ccggggcacc tgtgggcggt cgtcacggac
    19561 gccgacccgc gctggctgac cctggccgtc ctggccaacg tggcctcgca ggtgacccgt
    19621 gccctcggct ggaacgccat gttcaccggg tcccggatcc gcctgggcct cctggtacgc
    19681 atcgagttcg ccgtacaggc ggcggccgcc gtcagcccgg agggggtggg cgagttcgtc
    19741 cgggtgggct acctcctgcg cgagggggtg gcccggacgg tgaccgtcac gctcatgctg
    19801 gtccgcaagt tcttctccag cctgggtctg gtgcccttcc tggtggtcat ctggtggccg
    19861 ggcagtggga tgcccggctg ggcggtggcc gtcgcctggg cgtacctggc ggtgctgacc
    19921 gtggagtccc tcctgatcgt gcgggtcgcg cgcaccccgt cggccccggc ccgggagggc
    19981 cgactgcggc agatcgtctt cgacgcgcgc acctccctcg ggccggtgcg acggccacgc
    20041 gtcttcgcgg aggtgggggc ggccgggctg gtcaccaggg cgctcgacct ggtggccgcc
    20101 gcggcggtcg cgaaggccct cggcctgggg ctgtcggcgg ccgtcctggt gctggtcctg
    20161 ctgtcggtcg aggtgtccaa catcatgccg accctgccgg gtcaggtggg caccttcgag
    20221 gcggccgtgc tggcggcgac ggccggtgtc ctcggacagg ccgaagggtt ggccttcgca
    20281 ctggttttcc atgcccaaca agtgcttccc cagatcccgc tggggatgat gacgatggca
    20341 ggccgttcac tcctgccgaa ccgatcgaaa caggatccga catgaccgaa ccatggaacg
    20401 ccgatactcc caaggtgatt cagctcccct ccgggcggcg gatccggggg cgcggcctca
    20461 ggtacgacct gccggagggg cagaccccga cctttgccgt acacctgacg gaccaccggc
    20521 cggccgacca gccgtgggaa tcggtgtggg tgccctggcg ggacttctgg ctgcccgccg
    20581 acccggcgga ggcgatggcc aagctccgcc tggcgtacga gcgggcgtcg agcgagcggg
    20641 tggagatctg ctgcggaggg ggcatcggcc ggacggggac ggcgctgtcc gcgatctgcg
    20701 tcttcgaggg catggacccc aaggaagcgg tcaagtgggt gcggaagaac taccactcgc
    20761 gtgcggtcga ggtgccctgg cagcggcgtt tcatccgcca gaccttcgcc gccgacgcat
    20821 ccggcggagg gcgggccgac cactcgtgac gagcaggtga gcgagacgcc cggccagaac
    20881 ttccggccgg gcgtctccgc tgtgcggccg aagggaaata cgggggctag cccccgtgtt
    20941 ccggcgcgcc cgcgctcgta acgtaacggg tatggaagcc cgagaccacg agatcgagaa
    21001 ggagctcgcc gccaccctcc aggcgcgccg cgagctgggt ccggagtacg agtccgcgct
    21061 cgtcgactcg ttcctggaga aggtcgagca gcgcctcgac accaccctgg accgccaggt
    21121 ccggcgccac ctcgccgagc agcaggtgac ggccgcccgg gacccccggt ccatatcgcc
    21181 gccgtccgcc ggggcgctgt ccggcttcgg ggagcggttc gggttcgggg tcgtctcgct
    21241 cgtgctggcc gtcccgctct ccgcgatcgg ggtcgccaac gcgggcatcg aggggctggt
    21301 ggtggcctgg atggggatcg tcggggtgaa cgtggcccac gcggcgcgcg gcgggggcct
    21361 gttccggcag cgggggcggg agcggcgcgc ggccccggcc tcggagtggc aggactgacc
    21421 gggtgacata ggtggcgtga ccgcgcacgt gacacaggtg acgcacggga cgtggccggg
    21481 aacggccgcg cggccgggcc cacggggggt ccggccgcgc gtccagggga tacccctgag
    21541 gtatgtcgcg ggggccgccg cacccccggt ggcccggggg gcgggacgac ggcggtcccc
    21601 gcgaaggacg cggtccgggt cagggccgga tgcccgcgtc cgggcgacgg tggaggtccg
    21661 ggagccgctc cgtagtccgg tgtcgccgtt ctgggtgccg gcgggtttcc ctgccgacac
    21721 ccaccaatgt gccggagccg tgttaagcgg gtgctgcgcg gacgtgacgc gctcgtaccg
    21781 ttttcgcgaa gccctgaccg cgaccggccc cggccggacc tgaccgggtc agaccttcgc
    21841 ggacccggcg tccttcgcga ggaacgccag cacgtcctgc ctgctcacga cgcccttcgg
    21901 cttgccctcg acgagcacga tcgccgcgtc cgcaccatcg gcaccgctga gcgcggccat
    21961 caggtcctcg accggctcgc ccgagccgac ctgcggcagc ggggccgaca tgtgcttctc
    22021 cagcgggtcg ctgagcgagg cgcgctgggt gaacagggcg tccagcagct gccgctcgac
    22081 gacggagccg atgacctcgg cggccatcac gtcggggtgt ccggcgcccg gcttcacgat
    22141 cggcatctgg gagacgccgt actcgcgcag cacgtcgatt gcctgaccga ccgtctcgtc
    22201 cgggtgcatg tggacgaggg agggcagcgg gccctccttg aagttcagca ccgcgctgac
    22261 ctgcggggag gagctggtgt cctccaggaa gccgtagtcg gccatccact cgtcgttgaa
    22321 gatcttgctg aggtagccgc ggccgctgtc gggcagcagc accaccacga cgtcgtccgg
    22381 gccgagccgc ttggcgacct ccagggcccc gacgaccgcc atgccgcagg agccgccgac
    22441 gagcaggccc tcctccttgg cgaggcggcg ggtcatctgg aaggtgtcct tgtcggagac
    22501 cgcgacgatc tcgtcggtga cctcggcgtc gtaggcggag ggccagaagt cctcgccgac
    22561 gccctcgacc aggtacggcc ggccggagcc gccggagtag accgagccct ccgggtcggt
    22621 gccgatgacc tggacggcgc ccttgctgat ctccttgagg tagcgcccgg tgccggtgat
    22681 cgtgccgccg gtgccgacgc ccgcgacgaa gtgggtgatc ttcccctccg tctgctccca
    22741 cagctcggga ccggtggtct cgtagtgcga gcgcgggttg ttcgggttgg agtactggtc
    22801 cggcttccag gagcccggcg tctcggcgac cagccggtcg gagacgttgt agtacgagtc
    22861 cgggtgctcc gggtcaaccg cgctggggca gacgacgacc tcggcgccgt acgcgcgcag
    22921 cacgttgatc ttgtccgtgg acaccttgtc cgggcagacg aagatgcact tgtagccctt
    22981 ctgctgggcg acgatcgcca ggccgacgcc cgtgttgccg ctggtcggct cgatgatcgt
    23041 gccgccgggc ttgagctcgc cgctctgctc ggccgcctcg atcatgcgca gggcgatgcg
    23101 gtccttcacc gacccgccgg ggttgaagta ctcgaccttg gccaggacgg tcgcctggat
    23161 gcctgccgtg acgttgcgca gcctcaccag cggggtgttg ccgacaagag tgatcagcga
    23221 atcgtggaat tgcaccgtgt actccgggat ctccgagatg gtccggccca gagtatgcgt
    23281 acgggccgga cgatgcgtac gtacgggctc cgtcccggga aagggaggcc ggaaagcgag
    23341 gtcggacacg gagcgtacgg gcctggagac gcgcggtgcg attgggcggc gcacttcacg
    23401 gggcaggtag gtacatgtag ggcggtacgg cgagaaggag gtggaccgga ctgtgtcgag
    23461 agcaagggtg gcacggcgga tcgcggcggg cgcggcttac ggcggtggca gcatcggact
    23521 gatcggtgcg gcggccgtcg gcgtgttcct ggcggaggtc cagctcgcga agaggcaggt
    23581 gggcggcggt acggcaccgg ttccgcccag tgcggacggg cggtacgggg tggcgttcgc
    23641 gggcccgaac gatccgttgc ggctcgggat gctgggggat tcgacggcgg cgggccaggg
    23701 cgtgcggcgg gccgggcaga ccccgggggc gctgctcgcc tcggggctcg cggcggtgtc
    23761 cgagcggccg gtggacctgc ggaacgtggc cctgccgggg gccaggtcgg acgatctgga
    23821 gcggcaggtc tcgctgctgc tcgcggaccc ggcccgtacc ccggacgtct gcgtgatcat
    23881 gatcggggcg a
//
