LOCUS       NZ_KB891308            24481 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. ScaeMP-e10 B061DRAFT_scaffold_2.3, whole genome
            shotgun sequence.
ACCESSION   NZ_KB891308
VERSION     NZ_KB891308.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. ScaeMP-e10
  ORGANISM  Streptomyces sp. ScaeMP-e10
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 992189)
  AUTHORS   Stepanauskas,R., Sieracki,M., Masland,D., Poulton,N., Swan,B.,
            Garcia,M.M., Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C.,
            Tapia,R., Chen,A., Kyrpides,N., Mavromatis,K., Markowitz,V.,
            Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G., Pagani,I.,
            Pati,A., Goodwin,L., Nordberg,H.P., Cantor,M.N., Hua,S.X. and
            Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Improved High-Quality Draft of Streptomyces sp. ScaeMP-e10
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 992189)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   3  (bases 1 to 992189)
  AUTHORS   Stepanauskas,R., Sieracki,M., Masland,D., Poulton,N., Swan,B.,
            Garcia,M.M., Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C.,
            Tapia,R., Chen,A., Kyrpides,N., Mavromatis,K., Markowitz,V.,
            Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G., Pagani,I.,
            Pati,A., Goodwin,L., Nordberg,H.P., Cantor,M.N., Hua,S.X. and
            Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. ScaeMP-e10
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            Isolation Site                    :: Gulf of Mexico
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:00:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,185
            CDSs (total)                      :: 7,109
            Genes (coding)                    :: 6,996
            CDSs (with protein)               :: 6,996
            Genes (RNA)                       :: 76
            rRNAs                             :: 6, 1 (5S, 16S)
            complete rRNAs                    :: 6, 1 (5S, 16S)
            tRNAs                             :: 66
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 45 of 113
            Pseudo Genes (incomplete)         :: 82 of 113
            Pseudo Genes (internal stop)      :: 12 of 113
            Pseudo Genes (multiple problems)  :: 23 of 113
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:33:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 784481
            Orig. end                         :: 808962
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB891308.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405355
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24481
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="10"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24481
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24481
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14481](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14481
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(63..74)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.66"
                     /tool="antismash"
     misc_feature    complement(134..147)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            339..602
                     /locus_tag="B061_RS0120235"
     CDS             339..602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513344.1"
                     /locus_tag="B061_RS0120235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018513344.1"
                     /transl_table=11
                     /translation="MTASHLLVPVPIPDRVAALIGSCIPPHILEAEFEADCAAREVRRF
                     RGPRLGIEDQADREQALAELARANKVLAAHHPRLTVGPGSFS"
     gene            673..1521
                     /locus_tag="B061_RS0120240"
     CDS             673..1521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491952.1"
                     /locus_tag="B061_RS0120240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018513345.1"
                     /transl_table=11
                     /translation="MTAPAGAPRPALLLVTDLAYEARGRRYCDEDIFLASRLRETFDVA
                     LCHPRDAAALLDRFDLALVRNSGPVLHYQEAYDAFRARALELGVPVYNPLDGRGDMAGK
                     EYLVELSRAGFPVIPTVDRAGDLGLLPEAGAYAVKPKLGADSVGLRFVGGAEVAGELER
                     EGEGVLLVQPRIDFRYEVSFYFVDHDFQYALYAPDPERRWVLEPYAADAADLAFARRFI
                     EWNALGHGIQRVDACRTAEGELLLVELEDLNPYLSLDRVDEEVRGAFVARLKASVAALI
                     G"
     gene            1579..3672
                     /locus_tag="B061_RS0120245"
     CDS             1579..3672
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513346.1"
                     /locus_tag="B061_RS0120245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MDR family MFS transporter"
                     /protein_id="WP_018513346.1"
                     /transl_table=11
                     /translation="MTTASEQAPAAQSAAAPPPVLDRRRRNIVFATIVLGMLLAALDQT
                     IVGTALPTIVSDLGGAEHMSWVVTAYLLAETVATVLVGKFGDLFGRKLVFQVSAIVFIT
                     GSFLCGLASDMLLLIIWRGMQGIGAGGLMVTSMALIADVIPLRERGKYQGAIGAVFGIS
                     TVIGPLLGGLFTDHLTWRWAFYVNVPIAIVVVIAAARNIPSVKAAGRPVIDYVGIALVA
                     VGASALILATSWGGNEYGWGSPMIIGLFIGGIIALTLFCLVETRAKEPMLPMRLFRNPV
                     FTVCSILSFIVGFAMLGSMIFLPTYLQYVDGDSATLSGVRTLPLVAALLVASIFSGTVV
                     SRTGRYRVFPIVGTLVMAAGLFLLSRMGPESGVWVESLYMVVLGLGIGLAMQVLTIAVQ
                     NTVDYADLGTATSGVTFFRTLGSAFGTAVFGTIYANALKPNLTEGVGQAVAAGGDPAVL
                     ARASESPQALHALPAAQVEPLAQAYAQTLHTVFLWTVPVALIGFVVALFLKEVKLRDSA
                     RLASTDMGDGFAQPGSGDSEKLLEISVAAILHGAGPDTARRIVTGSDTRLDMAGAWAVM
                     QVDLFTRMVGHAGLRLIAARHRLPPEVLVPVFDRMIEEGYLSGDGRIFSHTAAGRREAA
                     VISDAWGRWLNERLAEDGARPDDAQLRIAVDVIAKRLLAEDLAQELSPAPHPGSSTRVG
                     APA"
     gene            complement(3682..4272)
                     /locus_tag="B061_RS0120250"
     CDS             complement(3682..4272)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612620.1"
                     /locus_tag="B061_RS0120250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_018513347.1"
                     /transl_table=11
                     /translation="MNDDEEAAPYATRERFWRGEHLAFTPMEPDDAELIQHWRADPVAA
                     QEIGVWPGPLHDLRERLVSYVEDRDRDDFLILLPDDTPIGHTALHSQDFADGTAEAYLL
                     LAPEHRSKGYGADALAALTDLAFGELPLHRVEAVTHTDNVPSLATLKKAGFTREGVRRS
                     SCLHRGRRHDNALLALLRTEWEAQTRPRSWDHV"
     misc_feature    4306..4317
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.57"
                     /tool="antismash"
     gene            complement(4347..4790)
                     /locus_tag="B061_RS0120255"
     CDS             complement(4347..4790)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552529.1"
                     /locus_tag="B061_RS0120255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YchJ family metal-binding protein"
                     /protein_id="WP_018513348.1"
                     /transl_table=11
                     /translation="MSRRTSRPRRPAAPQAPRITPASPCPCGLTATYGECCGRFHSGGA
                     AAPTCEALMRSRYAAFVVQDAAYLLRTWHPETRPPGVDFDPAMRWTGLEILETTEGSAF
                     HTTGTVTFRAHYTDDGRPDSLHEHSRFVRHEGAWVYATAVFVD"
     gene            complement(4859..5848)
                     /locus_tag="B061_RS0120260"
     CDS             complement(4859..5848)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612618.1"
                     /locus_tag="B061_RS0120260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_051104659.1"
                     /transl_table=11
                     /translation="MAKESSHRETHGNAHRAVMIVSAGSNPFEMGVATELFGLRRPELP
                     VDWYDFALCSPTPTVRMHAGFFQLSGVRGLDAVDRADTVIVPNRPDPLEDPGPEVLAAV
                     RRAADRGARLVSFCTGTFTLAAAGVLDGRRATTHWRWAEAFTARYPQVDLQPDVLFVDD
                     GQVITAAGSAAALDTSLHLVRADHGAEIAAAVSRRLVHPAHRDGGQRQFIEHPLPEVAD
                     ASLAPLLDWAAEHLTEGLDVSALAARAAVSPATLHRRFRAQLSTTPLAWLTEQRTTLAC
                     RLMERGEDRLDVIARTCGLGTATNLRTQLRRRTGLTPTEYRSRFAAGR"
     misc_feature    5841..5855
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            5901..6356
                     /locus_tag="B061_RS0120265"
     CDS             5901..6356
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612617.1"
                     /locus_tag="B061_RS0120265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cupin domain-containing protein"
                     /protein_id="WP_018513350.1"
                     /transl_table=11
                     /translation="MTTDPARPATEPILIDDALGSFDALWSPRIMTRVNDYDVRVAKVH
                     GEHVWHVHENTDEFFLVVEGELDIALRDGDGPEDERTVTLPRGAVFVVPRGTWHRPYAA
                     DGASLLLFEPSGTSTVGDAHDPVPDHVDATTGHALTDRLQGLRATPA"
     gene            complement(6329..7138)
                     /locus_tag="B061_RS0120270"
     CDS             complement(6329..7138)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491948.1"
                     /locus_tag="B061_RS0120270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_018513351.1"
                     /transl_table=11
                     /translation="MTGQDPQAIEIDTSKPHPARMYDWFLGGKDNYPVDEQMARRLLQL
                     DARGRDMARVNRAFMHRATRWLAEQGVRQFLDIGTGIPTEPNLHQVAQQTAPDARIVYC
                     DNDPIVLAHAAALLRSTPEGATEYIQADARKPEAILAAAGKVLDFEKPIALSLLALLHF
                     IDDEDGAAELVDKLVDQLPSGSYLVLSHTTGDFNPEGAAQARAMYKERGMTLRPRSRAE
                     LTAFFDGLELVEPGVSLSADWRPELGEVIDVPGDEPIPGYAGVARKP"
     misc_feature    7151..7165
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(7183..7419)
                     /locus_tag="B061_RS0120275"
     CDS             complement(7183..7419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955330.1"
                     /locus_tag="B061_RS0120275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_018513352.1"
                     /transl_table=11
                     /translation="MNHIYNGMPAADLGSEGWYKPWSGGNGGNCIEAMKLADGRVAVRQ
                     SADPDGPALIYSNGEIAAFIQGAKSGQADFLLT"
     gene            complement(7419..8279)
                     /locus_tag="B061_RS0120280"
     CDS             complement(7419..8279)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006135308.1"
                     /locus_tag="B061_RS0120280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_018513353.1"
                     /transl_table=11
                     /translation="MSEPRSAPTVGQVVLGKRLQDLRERVGLTRDQAAKVLRVAPATIR
                     RMETAEVGLKIPYVQLLLKAYGIADDEAEAFVDLAEEANKPGWWQRFHDVLPDWFSMYV
                     SLEGAASLLRMYEPHFIPGLLQTEDYARSVMRTGAVGQTRPEDIERHVALRMERQSLLA
                     KEDAPRLWVIMDETVLRRPVGGPQVMRAQIDKLLEATELPHVTLQIAEFASGHHPGTYG
                     PFVLFRFAVPELPDMVFSEYLTGAVYFDARPEVASYLEVMDRMAAQAATAQRTKEILRD
                     FRKEL"
     misc_feature    complement(8303..8319)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     gene            8487..8945
                     /locus_tag="B061_RS0120285"
     CDS             8487..8945
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018513354.1"
                     /locus_tag="B061_RS0120285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_018513354.1"
                     /transl_table=11
                     /translation="MAPGSALIPRLMDLSPGTEALRYCFALPAHPESVAGARQLTRARL
                     ESWKLGGDVYDAAVLIVSELVTNAVVHTASTRVVCELRCLGRRLRIAVQDQGHQPGGPR
                     LRRCSDDEHGRGLLLVDTLSSSWGSHDAGDDSGRIVWAELPHGVEQPC"
     gene            8939..9376
                     /locus_tag="B061_RS0120290"
     CDS             8939..9376
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519736.1"
                     /locus_tag="B061_RS0120290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018513355.1"
                     /transl_table=11
                     /translation="MLRNALSRLRGTPRPRAAEESRGGRVQLSLPPSMSASLGCDAVGV
                     PARHGFRLMSHLPRTGCVFAEADRWWWIVPSGSDLDLDWPEQVTYAAGALVRAVRPRLI
                     HAPDSRTPYTPPIPLYLMVCQVTGAAPSWEPDGGPRAVSVH"
     misc_feature    complement(9701..9714)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            9740..9895
                     /gene="lanA"
                     /locus_tag="B061_RS37915"
     CDS             9740..9895
                     /codon_start=1
                     /gene="lanA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) strep_PEQAXS"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978597.1"
                     /locus_tag="B061_RS37915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SCO0268 family class II lanthipeptide"
                     /protein_id="WP_018513356.1"
                     /sec_met_domain="strep_PEQAXS (E-value: 1.1e-28, bitscore:
                     94.7, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTEMIVANDAADLDLDLRISEVTDQTQEFGAGTYTSPSSYAIGT
                     RCPVCC"
     gene            10001..13156
                     /locus_tag="B061_RS0120300"
     CDS             10001..13156
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179519.1"
                     /locus_tag="B061_RS0120300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_018513357.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.5e-175,
                     bitscore: 577.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9.9e-19,
                     bitscore: 63.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.1e-34, bitscore:
                     115.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPELDLELDLFEVREPVLVRMASTPRDRAESRVDAADPVPGLRR
                     MAADPLLRQAVEVASGSLSLSLQRLATDEGAAALGRKRTLSAARTLTRYARRAGGRPTP
                     FGLFAGVGRASFGSAAEARLTGPGEVSVRLDGGWLHRRVRDWLAVPQVRRRTDVVLSDL
                     CARRDGRLVLHTGGREISVHDNALVAAVREAAERPVPYTDLLDGLAARFPSVGPDRIDG
                     FLAGLVQHGFLLTSLTPHRIDAALLGRIEAAVDGAVPGAAEGLRAIRAAAAGHEADPPG
                     LGQNSWRALLSAVRTLDGSAADSGQRPPVHVDLRMPADIVLPRAVGDEVRRYAAAIWAM
                     TPEWTTLDHMRDYRDRFIERYGTASAVPLGDLVDPHRGLGLPPEYGAPAPAHPRVGPGE
                     DADRPRRAAIAELTQQAILDGGDIELTEADVARLAKAVGHTPGGRVPRTLELCFQILAD
                     SQEALDRGDFLLLGSPHIGSWTAGATAGRFAAVAGLTDELAALAAGPGDDDALMAQVDA
                     MPSDPRSLNIVQVPPLLPYRIPVGVADDRGDAHCLDWRALLVAAGEDGLRLLHAPTGRP
                     VVPVFPHMLALDAQAPPVARFLSDLAAARPRVWSGWDWAGLDVLPYLPRVRHGRVLTSP
                     RRWLAGRRLMDAARSASTSTWQDGLRDWRRRGRVPDRIQIARNDQMFPIDLREPWDQDL
                     LRAELTAKEPRFQLYEDLTADGAGLGWNSGHSTEIVVPLVRAARATAAAGPREDAPPLA
                     RSGIRISPTTVHLPGEDWLSVKLYAQKAAHDGLLADHLPALLAEVDADVDRWFFLRYRD
                     PDPHLRIRLHGEPAALRERVLPALTAFVRGLTASGAVRTMVLDAYRPETDRYLGAAAQE
                     AAEGLFLADSRSALIQLQARRAGAAAVPDEVLAAAGHAVLLDSLGDWDWCAWADHMFTK
                     GPDHEIYQRHRALADLLVRPGDMPGDTARRAARELRVPALTEVWTGSPEPQAYGKLVLA
                     ASEADRDEAVLSLLHMRHNRLFGIDQAAESRAYAVLRGAARTFIAARAHAARTTATADR
                     SVR"
     aSDomain        10472..10720
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B061_RS0120300_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="3.40E-20"
                     /identifier="RREFam001.1"
                     /label="B061_RS0120300"
                     /locus_tag="B061_RS0120300"
                     /protein_end="240"
                     /protein_start="157"
                     /score="63.5"
                     /tool="antismash"
                     /translation="VVLSDLCARRDGRLVLHTGGREISVHDNALVAAVREAAERPVPYT
                     DLLDGLAARFPSVGPDRIDGFLAGLVQHGFLLTSLTPH"
     gene            13153..14481
                     /locus_tag="B061_RS0120305"
     CDS             13153..14481
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020557575.1"
                     /locus_tag="B061_RS0120305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_018513358.1"
                     /sec_met_domain="LANC_like (E-value: 6.6e-58, bitscore:
                     191.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLHAAGPRERAGEVSEQILDRLADPAATMAATRIPAEASENGE
                     PENIWAEMTLGSGSPGLAIAFSGAARTGTDRTARAHAYLSAATRAASTGATSASGIFKG
                     PGALGFAVLMAHRTTGGYISALERLDGYQRDLVRTAMPAVPDNAPLSTIGHYEVVRGMT
                     GVGRYLLARAETCGEELETVLTYLTRLAQGEVEHRGHKVPRWWALDAPRIGSEADLPDG
                     HLNLGISHGVAGPLALLSLAWGQGVRVPGQREAIESAAALLTHWAVRDAYGLYWPPHLS
                     LADWLAGPDAFTAPAGWPSWCYGAPGVSRGLQLAGLALDRADWTGTANASVERLLALPM
                     ERWGINDNALCHGWAGALHQLGRLNEHVGDDRVEAVRDRIAADLVDAFDPELPFGFRFT
                     MTKTPFATDVSGYLDGAAGLALALDSYATGGTPADWDMPLLLA"
     gene            complement(14565..15911)
                     /locus_tag="B061_RS0120310"
     CDS             complement(14565..15911)
                     /EC_number="3.2.1.86"
                     /GO_function="GO:0008706 - 6-phospho-beta-glucosidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579618.1"
                     /locus_tag="B061_RS0120310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_026241709.1"
                     /transl_table=11
                     /translation="MKLTILGGGGFRVPLVYGALLGDHAEGRVTRVTLYDTDADRLTAV
                     ARVLEEQARGVPDAPAVVATTELDEALRGADFVFSAIRVGGLAGRAADERVALDLGVLG
                     QETVGAGGIAYGLRTVPVAVDLARRIARLAPHAWTINFTNPAGLVTEAMSRHLGDRVIG
                     ICDSPVGLGRRIARVLGADPDRAWIDYAGLNHLGWVRGLYVDGRDELPRLLADPELLGS
                     FEEGRLFGTDLLRSLGAIPNEYLHYYYFNREAVRSYQEAEQTRGAFLRDQQEGFYARMR
                     EPGTPALATWDRTRAEREATYMAENRDVAGAGEREESDLESGGYEQVALALMRAVARNE
                     RTSLILNVRNRTALSVLDADAVVEVPCLVDANGAHPVAVSPLPYHAVGLVTAVKAVERA
                     VLEAAESGSRSAAVQAFALHPLVDSVAVARRLVDRYTGVHSELAYLNAP"
     gene            complement(16000..17571)
                     /locus_tag="B061_RS0120315"
     CDS             complement(16000..17571)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378271.1"
                     /locus_tag="B061_RS0120315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_018513360.1"
                     /transl_table=11
                     /translation="MTTPFHHEPGAAPPPQCPAHNLGTGPGGLRRLYGPEAENDPAGLY
                     DKLRAEHGTVAPVLLHGDVPAWLVLGHSENLHLTRTPSQFSRDSRRWRALQDGSVAPDH
                     PLAPIFTWQPVCVFADGAKHERQRGAVTDSMERIDTRGVRRHINRFSNRLVNDFSEKGS
                     ADLVTQFADHLPMMVMCAIFGMPEEYDERLVQAARDMTRGTETAVASNAHIVAVLTRLV
                     ERRRAEPAPDFASWLVEHPATMTDIEVVEHLRLILIAAYESTANLIANVLRMVLTDPRF
                     RARLSGGHMTVPEAVEQTLWDEPPFTAVFGRWAVGDTELGGQQIKAGDALLVGIAPANT
                     DPTVRPDLTANMEGNRAHLAFSGGPHECPGQDIGRAIADVGVDALLMRLPDLELGVEES
                     ELRWVGNIMSRHLVELPVKFAPSPQQKLDSDPLSVMARAVRPTGDWEISSPARPVPEPA
                     HSLAGTQPAHAPGAAPQPRQAPAPADAPAPAPVAPAPGAAVVPQQRRPAAPARLWQAVS
                     RWWNGY"
     misc_feature    17583..17597
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
     misc_feature    complement(17721..17735)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.09"
                     /tool="antismash"
     misc_feature    complement(17758..17772)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.09"
                     /tool="antismash"
     gene            complement(17780..18394)
                     /locus_tag="B061_RS0120320"
     CDS             complement(17780..18394)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964952.1"
                     /locus_tag="B061_RS0120320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_010058144.1"
                     /transl_table=11
                     /translation="MDFRSSDTITGPRTEDVLPTTATAAVKVVIVGGFGVGKTTMVGSV
                     SEIRPLTTEETMTQAGVGVDDNAGVETKTATTVAMDFGRISLSEELILYLFGTPGQERF
                     WFLWNGLFEGALGAVVLIDTRRLEVSFDVIGRLEERGVPFVVAVNTFPDAPHHPVEALR
                     RALDLPDEVPMIDCDARLRASSRDVLMTLMRYLHSLAVPLA"
     gene            complement(18375..18746)
                     /locus_tag="B061_RS0120325"
     CDS             complement(18375..18746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964953.1"
                     /locus_tag="B061_RS0120325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_026241710.1"
                     /transl_table=11
                     /translation="MSGPRRERRKTDPALSDPERLYVITGDLDDSERAALDLVTMVVAQ
                     AEPSPTFQPEQAAILRLCQAPLSVAEISAYLSLPFSVVTSLLSDLLATELIESRAPIVR
                     ATLPDRSLLEAVMHGLQKL"
     misc_feature    complement(18546..18548)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18743..19150)
                     /locus_tag="B061_RS0120330"
     CDS             complement(18743..19150)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491940.1"
                     /locus_tag="B061_RS0120330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_006128841.1"
                     /transl_table=11
                     /translation="MIQQRGNMDWMLKELADDVPSIHQIVVLSSDGLRIAMHGGDPDVA
                     DRLAAACAGLQSLAAAVATEIPYSDGLMKLVVIEVTGGFFYLMAAGTGAYLAVLAGETV
                     DAGLVGARMRDMVVRIGAHLTSPPRHGGQSG"
     gene            complement(19147..20826)
                     /locus_tag="B061_RS0120335"
     CDS             complement(19147..20826)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128840.1"
                     /locus_tag="B061_RS0120335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_026241711.1"
                     /transl_table=11
                     /translation="MVRVESPPTDREVPVVRVVLPPVVLLAGATAAGVALVVPAARIPV
                     AVCGAITTLVVAVLTVALHRRRRAMAAQRAEYEQRIAYLEHRILSHDSETVRLTKEVMP
                     AAIRRLRVGNSPEEVMRDIVDADAANRHLPKALREQIYQVLEVIDNEEARRDSAQRAFV
                     SVARRVQAIVHRQASELREMEDHYGRNPEVFDDLLRIDHGTALIGRLADSIAVLGGARP
                     SRQWPKPVPLFSVLRGAMSRILEYQRVDLHSIAKVAIVGTSVEPLIHACAELLDNATRY
                     SPPQTRVHVTAVEVQTGIAIEIEDGGVSLSEEARARAENMLAQAQAGINMNDLGESPRL
                     GMAVVGRLSRMYQLQVSLRQSAYGGVRAVLIVPRDMITTGPAPGIAHGIGATSRPTSSL
                     DMSQLQHVVPPPGKRKSKPKPAATGPVPSVVAPAPAGAPAAAARPATPAAAMEDDVPVV
                     TEWTENGLPQRRSRGRAPLGSHNLPQQPPPPPAPANGGLPSRGGHPDGGYGAPAGPGGP
                     GGSGEKPPGLWLEAFTKAVNGVPQEPKHGEDSDDAWDKGDLK"
     gene            21396..22160
                     /locus_tag="B061_RS0120340"
     CDS             21396..22160
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612607.1"
                     /locus_tag="B061_RS0120340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_018513362.1"
                     /transl_table=11
                     /translation="MTATGDYTIASLDTGLRAMRLFLTHDTLTVTEAAGHLRVGRSTAH
                     RVLSTLESRGFAIRDTSGRGYAAGPELVRLGRPAGFGRAARDRLGPVLEDAAGRTGETV
                     WSVALIGDQVIVTDGRESPHPVRVALELGRTGPAHAGSGGLLLLSRMTADQVCALYPDE
                     ALEAVTPATLTSRTALLDELAVIRRRGHAVSRGASVPGMTTVAVALAGSSWRDRLALVA
                     AAPADRSGDAALAERAERLRESAALLAPAPPA"
     gene            complement(22190..22696)
                     /locus_tag="B061_RS0120345"
     CDS             complement(22190..22696)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612606.1"
                     /locus_tag="B061_RS0120345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_018513363.1"
                     /transl_table=11
                     /translation="MTDDIVALVVRQWQAVDPELDTGPMEIIGRINRCAALLQQAEDAP
                     LRSAGLTRPEFDLLGAVRRTARELTPGELARETFSSGAAVTKRLRALQERGLVDRRGDE
                     RDRRVAHVRLTDEGRALVDRLLPEQLAYERAVLSGLDDGSRGELGSRLSELLVQLEGRI
                     GGARR"
     gene            complement(22693..24429)
                     /locus_tag="B061_RS0120350"
     CDS             complement(22693..24429)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018491937.1"
                     /locus_tag="B061_RS0120350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FUSC family protein"
                     /protein_id="WP_018513364.1"
                     /transl_table=11
                     /translation="MSDTPSDAAPRPRQPFARGLPLAAPLRLNRPSDTWFKPALSVVAA
                     SAVPHLTLLALGRLDLVMYTMAGSLCALYGHGLPYARRARTLAGVVLSMAAGLAAALVT
                     ASLTHSTAVLVAVGALLAAAQKAACDAVRIGPPGHVILTFVSSAALFAPQRLGQVPAHL
                     ALTLGAGAVAWLVCVGPALIRREGPERRAVARALEAAADRVAEPGPRTRHTAAAAVHAA
                     WQCLLASGRPTPVRRSLERLVVHAEAAGASAQPDQDPDRLRAWAALTRARGPVPEPPPA
                     PGTAAELYGIDAERAALRASGGRRAARRTLLRSLGPGSHLLPVAARTLIGCALAGYLCA
                     ALGVGRPYWAIVTAASLYQANTTLTWNRTLQRTLGNLLGVLVFAAVLPLSRTGPLALVL
                     CCLFFSFAAEALITRNYWLGSVAVTPMALLVLEFGGTHPAGELVGDRVLDTVLGALAGF
                     LAAALVTNRRAAGRVERALEAAAQARAAAERAYADRAHTGPDGLDRARRALTARLVELR
                     EAADIAAGEWWQRALPEQRLLAAERAGHRTLAATAQRQGPPVRAPDTRSGAVAPAPANG
                     AA"
     misc_feature    24439..24454
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.35"
                     /tool="antismash"
     misc_feature    24447..24462
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 23.84"
                     /tool="antismash"
     misc_feature    complement(24456..24470)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    24457..24468
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.72"
                     /tool="antismash"
ORIGIN
        1 agaccgtgcg ctaccgcatg cgcagcctgg agaccatctt cggtgatcaa ctcgtcgacc
       61 cggaaagccg tttcgcgacc gaggccgtgc tgcgtgcgtt acggctgcgc gcccgcccgg
      121 ccaacacatc ctcctgatcc ggatcatgtt tggcgcgaca ggtcaactta cccgcgcgta
      181 aggcgaaata gacggtcagt cccaaacggt tgcgacacgg agacgtatcc gacgagaaac
      241 ccggaaccgc gtcccgtaca caaggagggg tctgccgctc atccggcggc agcacccacg
      301 taccgcctcc tggccaacca tccgagaggg aacaccccat gaccgcctcg cacctcctcg
      361 tccccgtgcc gatcccggac cgggtcgccg cgctgatcgg ctcgtgcatc ccgccgcaca
      421 tcctggaggc ggagttcgag gccgactgcg cggcccgtga ggtccgcagg ttccgggggc
      481 cccggctggg catcgaggac caggccgacc gcgagcaggc cctcgccgag ctggcacgcg
      541 ccaacaaggt gctggccgct caccaccccc ggctgacggt ggggccgggg tcgttctcgt
      601 agcccggcgg cggcccgtgg acacgggtca gggatagtga gcgtccgtcc cagcgctcac
      661 cccggagaag ccatgaccgc ccccgccggc gccccccgcc ccgccctcct cctcgtcacc
      721 gatctcgcct acgaggcgcg cgggcggcgc tactgcgacg aggacatctt cctggcgtcc
      781 cggctgcgcg agacgttcga cgtcgcgctc tgccaccccc gggacgcggc cgcgctgctg
      841 gaccgcttcg acctcgccct cgtacgcaac agtgggcccg tcctgcacta ccaggaggcg
      901 tacgacgcgt tccgcgcgcg ggcgctggag ctgggcgttc cggtctacaa cccgctggac
      961 gggcgcggcg acatggcggg caaggagtac ctggtggagc tgagccgggc cgggttcccg
     1021 gtgatcccca cggtggaccg ggcgggcgat ctggggctgc tgcccgaggc cggggcgtac
     1081 gcggtcaagc cgaagctggg ggcggactcg gtggggctgc ggttcgtcgg cggggcggag
     1141 gtcgcgggcg agctggagcg ggagggcgag ggggtgctgc tcgtacagcc ccggatcgac
     1201 ttccgctacg aggtgtcctt ctacttcgtc gaccacgact tccagtacgc gctgtacgcg
     1261 ccggacccgg agcggcggtg ggtgctggag ccgtacgcgg ccgacgcggc cgacctggcg
     1321 ttcgcacgcc gcttcatcga gtggaacgcg ctcggccacg gcatccagcg ggtggacgcc
     1381 tgccgtacgg cggagggcga actgctcctc gtggagttgg aggacctcaa cccgtacctc
     1441 tcgctcgacc gggtcgacga ggaggtccgg ggggcgttcg tggcgcggct gaaggcgtcg
     1501 gtcgccgcgc tgatcggctg acgcccatcc ggacggtccc cgcatgcggg cggccggagg
     1561 cggtgtgagg gtgcagaggt gaccactgcc agcgagcaag cccccgccgc gcagagtgcc
     1621 gccgcgccgc cgcccgtcct cgaccggcgg cggcgcaaca tcgtcttcgc cacaatcgtg
     1681 ctcggcatgc tgctggcggc gttggaccag acgatcgtgg gtacggccct gccgacgatc
     1741 gtctcggacc tgggcggcgc cgagcacatg tcgtgggtgg tcaccgcgta tctgctcgcc
     1801 gagacggtcg ccaccgtgct ggtcggcaag ttcggtgacc tgttcgggcg gaagctggtc
     1861 ttccaggttt cggcgatcgt cttcatcacc ggctcgttcc tctgcggcct cgcctcggac
     1921 atgctgctgc tgatcatctg gcgcggcatg cagggcatcg gcgccggcgg cctcatggtc
     1981 acgtcgatgg cgctgatcgc cgatgtgatt ccgctgcgcg agcgcggcaa gtaccagggc
     2041 gcgatcgggg cggtcttcgg catctcgacg gtgatcggac cgctgctcgg cgggctcttc
     2101 accgaccatc tgacctggcg ctgggccttc tacgtcaatg tgccgatcgc gatcgtggtg
     2161 gtgatcgccg ccgcccgcaa catcccgtcg gtgaaggccg ctggacggcc ggtcatcgac
     2221 tacgtgggca tcgccctggt cgccgtcggc gcgagcgcgc tgatcctcgc gacgagctgg
     2281 ggcgggaacg agtacggctg gggctcgccc atgatcatcg ggctgttcat cggcgggatc
     2341 atcgccctga cgctgttctg cctggtggag acgcgggcga aggaaccgat gctgccgatg
     2401 cggctgttcc ggaatccggt gttcaccgtc tgctcgatcc tcagcttcat cgtgggtttc
     2461 gcgatgctcg gctcgatgat cttcctgccg acctacctcc agtacgtgga cggggactcg
     2521 gcgacgctct cgggcgtgcg gaccctgccg ctggtcgccg cgctgctggt cgcctcgatc
     2581 ttcagcggca cggtggtcag caggaccggg cgctaccgcg tcttccccat cgtcggcacg
     2641 ctggtcatgg cagccgggct gttcctcctc tcccgcatgg ggccggagag cggggtgtgg
     2701 gtggagtcgc tctacatggt ggtgctgggg ctcgggatcg ggctggccat gcaggtgctg
     2761 acgatcgccg tgcagaacac cgtcgactac gcggacctgg gtacggcgac ctcgggcgtg
     2821 acgttcttcc gtacgctcgg cagcgccttc ggcacggccg tgttcgggac gatctacgcc
     2881 aacgcgctga agcccaacct caccgagggg gtcggccagg cggtggcggc gggcggcgat
     2941 ccggcggtcc tggcccgggc ctcggagagc ccgcaggccc tgcacgcgct gcccgccgcc
     3001 caggtggagc cgctggccca ggcgtacgcg cagacgctgc acaccgtgtt cctctggacg
     3061 gttccggtgg cgctgatcgg cttcgtcgtc gcgctgttcc tcaaagaggt gaagctgcgg
     3121 gactcggccc ggctcgcctc gacggacatg ggtgacggct tcgcccagcc cggcagcggc
     3181 gactccgaga agctcctgga gatctcggtg gccgcgatcc tgcacggagc gggtccggac
     3241 acggcccggc ggatcgtcac cgggtccgac acccggctgg acatggcggg ggcctgggcg
     3301 gtgatgcagg tggacctctt cacccggatg gtcggccatg cggggctgcg actgatcgcg
     3361 gcccggcacc ggctgccgcc ggaggtgctg gtccccgtct tcgaccggat gatcgaggag
     3421 ggctacctca gcggggacgg ccggatcttc tcccatacgg cggcgggccg gcgcgaggcg
     3481 gccgtgatct ccgacgcctg gggccgctgg ctcaacgaac ggctcgcgga ggacggggcc
     3541 cggccggacg acgcgcagct ccgcatcgcc gtggacgtga tcgcgaagcg gctcctggcg
     3601 gaggacctgg cccaggagct ctccccggcg ccccacccgg gcagctccac ccgggtgggg
     3661 gcaccggcct gatccctcgg gtcagacgtg gtcccaggac cgggggcggg tctgcgcctc
     3721 ccactccgta cggagcaggg ccaggagcgc gttgtcgtgg cggcgccccc ggtgcaggca
     3781 ggaggaccgg cggacgccct cccgcgtgaa ccccgccttc ttcagagtgg cgagggaggg
     3841 gacgttgtcg gtgtgggtga cggcttccac ccggtgcagg ggcagctcgc cgaaggccag
     3901 gtcggtgagg gcggccagcg cgtcggcgcc gtaccccttg gagcggtgct cgggggcgag
     3961 caggagatac gcctcggcgg tgccgtcggc gaagtcctgg ctgtggaggg ctgtgtggcc
     4021 gatgggggtg tcgtccggga gcaggatgag gaagtcgtcg cggtcccggt cctcgacgta
     4081 ggagacgagc cgttcgcgga gatcgtggag cggtccgggc cagaccccga tctcctgggc
     4141 ggcgaccggg tcggcgcgcc agtgctggat cagctcggcg tcgtccggct ccatgggggt
     4201 gaaggccagg tgctcaccgc gccagaatcg ttcccgcgtg gcgtacggcg ctgcctcttc
     4261 gtcgtcgttc atgcgcggat cgtacgaggc cttccgcgct ggtgggaaag gggtttcggg
     4321 ccccgcgagc ggagctgggc ccggtctcag tcgacgaaga ccgccgtcgc gtagacccag
     4381 gcgccctcgt ggcggacgaa gcggctgtgc tcgtggaggg agtcggggcg cccgtcgtcg
     4441 gtgtagtggg cgcggaaggt gacggtcccc gtggtgtgaa aggcgctgcc ctcggtggtc
     4501 tccaggatct ccagccccgt ccagcgcatc gcggggtcga agtcgacgcc cggcgggcgg
     4561 gtctcggggt gccaggtgcg caggaggtac gccgcgtcct ggacgacgaa ggccgcgtac
     4621 cgggagcgca tcagggcctc gcaggtcggg gcggcggcgc cgccggagtg gaaccggccg
     4681 cagcactccc cgtacgtcgc ggtcaggccg caggggcacg gcgaggcggg ggtgatgcgc
     4741 ggggcctgcg gggcggcggg ccgccggggg cgggaggtgc gtcgtgacat gggtccattg
     4801 tcacccggtc cggcgcgccg gccctccccg gtgccccgcc cgccggcgcc ccttccgctc
     4861 agcgtcccgc cgcgaaccgg ctgcggtact ccgtgggcgt cagccccgta cggcggcgga
     4921 gttgcgtacg gaggttggtc gccgtgccga ggccgcaggt gcgggcgatc acgtcgaggc
     4981 ggtcctcgcc gcgctccatg aggcggcagg ccagcgtggt gcgctgctcg gtcagccagg
     5041 ccagcggggt ggtggagagc tgggcccgga agcggcggtg gagggtggcg gggctgacgg
     5101 ccgcgcgggc ggcgagcgcg gacacgtcca ggccctcggt caggtgctcg gcggcccagt
     5161 ccaggagcgg ggcgagcgag gcgtcggcga cctcgggcag cgggtgctcg atgaactggc
     5221 gctggccgcc gtcccggtgt gccgggtgga ccagcctccg gctgacggcc gccgcgatct
     5281 cggccccgtg gtcggcgcgg acgaggtgga gggaggtgtc cagggcggcg gcgctgcccg
     5341 ccgcggtgat cacctgtccg tcgtcgacga agagcacgtc gggctggagg tccacctgcg
     5401 ggtaccgggc ggtgaacgcc tccgcccacc gccagtgcgt ggtggcgcgc cggccgtcca
     5461 ggacgcccgc ggcggcgagt gtgaacgtcc cggtgcagaa gctgaccagc cgggcgccgc
     5521 gatcggcggc gcgccggacc gccgccagga cctccgggcc ggggtcctcc agcgggtcgg
     5581 gccggttggg gacgatgacg gtgtcggcgc ggtccacggc gtcgagcccg cggacgccgg
     5641 agagctggaa gaaacccgcg tgcatccgga ccgtgggggt gggcgagcag agcgcgaagt
     5701 cgtaccagtc cacgggcagc tcggggcggc gcaggccgaa gagctcggtc gccacgccca
     5761 tttcgaaggg gttcgaaccg gccgagacga tcatgaccgc cctgtgcgcg ttcccgtgcg
     5821 tctcccggtg cgaggattct ttcgccatat gcgattcgta gcactcacgg gttcggcggt
     5881 ccagcgccca gggtggaggt atgaccacgg acccggcacg acctgccacc gaaccgatcc
     5941 tgatcgacga tgccctcggc tccttcgacg cgctgtggag cccgcgcatc atgacccgcg
     6001 tcaacgacta cgacgtacgc gtcgccaagg tccacggcga gcacgtctgg catgtgcacg
     6061 agaacacgga cgagttcttc ctggtggtgg agggcgagct ggacatcgcc ctccgcgacg
     6121 gggacgggcc ggaggacgag cggaccgtga cgctcccccg gggcgcggtc ttcgtcgtgc
     6181 cgcgtgggac ctggcaccgc ccgtacgcgg cggacggtgc ctccctgctg ctcttcgagc
     6241 cctcaggtac gtcgacggtg ggcgacgccc acgaccccgt accggaccat gtggacgcga
     6301 cgacgggcca tgcgctcacg gaccggcttc agggcttgcg cgcgactccc gcgtagcccg
     6361 ggatcggctc gtcacccggt acgtcgatga cctcgccgag ctccggccgc cagtcggcgg
     6421 agagcgagac gcccggctcg acgagctcca ggccgtcgaa gaaggcggtg agctcggcgc
     6481 gcgagcgggg gcgcagggtc atcccgcgct ccttgtacat ggcccgtgcc tgcgcggcgc
     6541 cctccgggtt gaagtcgccg gtggtgtgcg agagcaccag atagctgccg gaggggagct
     6601 ggtcgacgag cttgtcgacc agctcggccg cgccgtcctc gtcgtcgatg aagtgcagca
     6661 gggccagcag ggagagcgcg atcggcttct cgaagtccag gaccttgccg gccgcggcca
     6721 ggatggcctc gggcttgcgg gcgtcggcct ggatgtactc ggtggcgccc tcgggggtgg
     6781 agcgcagcag ggccgccgcg tgggcgagga cgatcgggtc gttgtcgcag tacacgatcc
     6841 gcgcgtcggg cgcggtctgc tgggcgacct ggtggaggtt cggctcggtg ggtatgccgg
     6901 tgccgatgtc caggaactgg cgtaccccct gctcggcgag ccagcgggtg gcccggtgca
     6961 tgaaggcacg gttcacccgg gccatgtccc ggccccgggc atccagttgg agcagccggc
     7021 gggccatctg ctcgtcgacc gggtagttgt ccttgccgcc gaggaaccag tcgtacatcc
     7081 gggcgggatg cggcttgctc gtgtcgatct cgatggcctg agggtcttgc ccggtcatgg
     7141 cgcactccgt ggatagggtc ggacaggata tgtggtggtg cgtcaggtga gaaggaaatc
     7201 cgcctggccc gacttggcac cctggatgaa cgcggcgatc tcaccgttgg agtagatgag
     7261 cgcggggccg tccggatcag cggactggcg caccgcgacc cggccgtcgg cgagcttcat
     7321 ggcctcgatg cagttgcccc cgttgccgcc gctccagggc ttgtaccagc cttcggagcc
     7381 gaggtcggcg gccggcatgc cgttgtatat gtggttcatc acagctcctt gcggaagtcc
     7441 cggaggattt ccttcgtgcg ttgtgcagtt gcggcctgag ccgccatgcg gtccatgact
     7501 tcgaggtatg aggcgacctc gggccgggcg tcgaagtaga ccgctccggt gaggtactcg
     7561 ctgaagacca tgtccgggag ttcgggtacg gcgaaccgga agaggacgaa cggcccgtag
     7621 gtgcccgggt ggtggccgct cgcgaactcc gcgatctgca gggtgacatg gggcagctcg
     7681 gtggcttcga gcagcttgtc gatctgggcg cgcatcacct gggggccgcc caccggccgc
     7741 cgcaggacgg tctcgtccat gatcacccag agccgggggg cgtcctcctt ggcgagcagt
     7801 gactggcgct ccatgcgcag ggccacatgg cgttcgatgt cctcgggccg ggtctggccg
     7861 acggctccgg tgcgcatcac ggagcgcgcg tagtcctcgg tctggagcag cccggggatg
     7921 aagtgcggct cgtacatgcg cagcaggctc gcggcgccct ccaggctgac gtacatgctg
     7981 aaccagtcgg gcaggacgtc gtggaaccgc tgccaccagc ccggcttgtt ggcctcctcg
     8041 gccaggtcga cgaaggcctc ggcctcgtcg tcggcgatgc cgtaggcctt cagcagcagc
     8101 tggacatagg ggatcttgag gccgacctcg gccgtctcca tcctgcgtat cgtcgcggga
     8161 gcgaccctga gcaccttcgc cgcctggtca cgggtcaggc cgacgcgctc ccgcagatcc
     8221 tgcaggcgct tgccgagcac gacctggccc acggtcgggg cggaccgcgg ttcgctcact
     8281 tcagacctcc ccatgcgctg ttttgcgagc agtgtgccac gcgtgcgccc ccaacgacac
     8341 agccactctg aaaatttcag agtgcccctt gccaagtgtc cccgtcaggg ggagagttgg
     8401 ctgtcgaacc agttcgctca gtcatgaccg ctcctctcac accggggaac gaagcgtgac
     8461 gcagccccca ctgtgaggaa tcggtcgtgg cacctggcag tgcgctcatc ccccggctca
     8521 tggacctcag ccccgggacg gaagcgctcc gttactgctt cgcgctgccc gcgcaccccg
     8581 agtcggtggc cggtgcgcgg cagctgaccc gggcccggct ggagagctgg aagctgggcg
     8641 gcgatgtgta cgacgcggcc gttctcatcg tgtccgagct ggtcaccaac gcggtcgtgc
     8701 acaccgcgag cacccgtgtg gtgtgcgagc tgcgctgtct cggcagacgg ctgcggatag
     8761 ccgtgcagga ccaggggcac cagccgggcg gcccccggct gcgccgctgt tccgacgacg
     8821 agcacgggcg cggcctgctg ctggtcgaca cgttgagcag ctcgtggggc tcccacgacg
     8881 ccggggacga ctccggccgc atcgtttggg cggagctccc gcacggtgtg gagcagccat
     8941 gctgaggaac gcgctgtccc ggctgcgcgg tacgccgcgc ccgcgggccg ccgaggaatc
     9001 ccggggcggc cgggtccagt tgtcgctgcc gccgtcgatg tcggccagtc tggggtgcga
     9061 cgcggtcggc gtgcccgcgc ggcacggctt ccgcctgatg tcccatctcc cgcgcaccgg
     9121 ctgcgtgttc gccgaggcgg accgctggtg gtggatcgtc ccgtccggct ccgacctgga
     9181 tctggactgg cccgagcagg tgacgtacgc cgccggagca ctggtgcggg ccgtgcggcc
     9241 ccggctgatc cacgccccgg acagccgcac gccgtacact ccgccgattc cgctgtatct
     9301 catggtgtgc caggtcaccg gagccgcacc gtcctgggag ccggacggcg gtccgcgggc
     9361 cgtgtccgtc cactgagacg ttccaccgcc aaatcgagcc atgcgctgtc ggacaccgtc
     9421 cgctgctgcc gatcggcgga ggacgccgct ccccttcgcg ctttcggttg ataacacctc
     9481 atcacagcgg tgtgcgtacc gtcgggaacg ggatgggaga tttcccgcac aacggcgtgg
     9541 aaaccgtcac atgaaagcgg cggggcccat ttcggcccag taactccacc tgaagcaccc
     9601 cgttccgatg gttcttacac ttggccgaaa accggctccc cggcgctgat gccacagtga
     9661 agagtgggga acgcggggcc gaacaacagc tccgatgcat caatcatttg ttcgcttcta
     9721 cgcacccttt gggggacgca tgcgcaccga gatgattgtc gccaacgacg ccgctgacct
     9781 ggaccttgac cttcggatct ccgaagtcac ggaccagaca caggaattcg gcgccggaac
     9841 gtacacctcg ccgagcagct acgcgatcgg cacccgttgt cccgtctgct gctgacacgg
     9901 cgcgacgtcc tgaccgatcc gggacgcgac tgaaatgagg cggggcgggc cgagcccgcc
     9961 ccgccttccc gcgtccaccg cgccatgggg ggaagccgac gtgcgacctg agctggacct
    10021 ggaactggac ctcttcgaag tccgcgagcc ggtgctcgta cggatggcga gtacgccgcg
    10081 cgaccgcgcc gagagccgcg tcgacgccgc cgacccggtg ccggggctgc gccgcatggc
    10141 cgccgacccg ctgctccgcc aggccgtcga ggtcgccagc ggcagcctct cgctcagcct
    10201 tcagcgcctc gccacggacg agggcgcggc ggcactcggc cgcaagcgca cactcagcgc
    10261 cgccaggacc ctcacgcgat acgcccgccg ggccggcggc cgtccgaccc cgttcggcct
    10321 gttcgccggc gtcggcagag cctccttcgg ctccgccgcc gaggcccggc tcaccggccc
    10381 cggcgaggtg tcggtccgcc tcgacggcgg ctggctgcac cggcgcgtcc gcgactggct
    10441 cgccgttccg caggtccgcc gccgcaccga cgtcgtcctg agcgatctgt gcgcgcgccg
    10501 cgacggcagg ctcgtcctgc acaccggtgg acgggagata tcggtccatg acaacgccct
    10561 cgtcgccgcg gtccgcgaag ccgccgaacg gcccgtcccg tacacggacc tgctcgacgg
    10621 tctggcggcc cgcttcccgt ccgtcggacc cgaccgcatc gacggcttcc tcgccgggct
    10681 cgtccagcac ggcttcctgc tcacctcgct cacgccgcac cgcatcgacg ccgctctgct
    10741 cggccgtatc gaagccgccg tcgacggagc cgtgccgggc gcggccgagg gcctgcgcgc
    10801 gatccgcgcc gccgcagccg gccacgaggc ggatccgccc ggcctcggcc agaactcctg
    10861 gcgcgctctg ctctccgccg tccgcacgct ggacggcagc gcggcggaca gcggacagcg
    10921 tccaccggtc catgtggacc tgcggatgcc ggccgacatc gtgctgccgc gggcggtcgg
    10981 cgacgaagtg cggcgttacg ccgccgcgat ctgggcgatg acgccggagt ggacgacgct
    11041 ggatcacatg cgggactacc gcgaccgctt catcgagcgg tacggaaccg cctccgccgt
    11101 gccgctcggc gacctcgtcg acccgcaccg cggcctcggc ctgccacccg agtacggcgc
    11161 tcccgcgccg gctcatccac gcgtcggccc cggcgaggac gccgaccggc cgcgccgggc
    11221 ggccatcgcc gaactcacgc agcaggccat cctcgacggc ggcgacatcg aactgaccga
    11281 ggccgacgtg gcccggctgg cgaaggcggt cggacacacg cccggcggcc gcgtgccgcg
    11341 cacgctcgaa ctctgcttcc agatcctcgc cgacagccag gaggctctcg accggggcga
    11401 cttcctgctg ctcggcagcc cgcacatcgg ctcctggacg gccggcgcga ccgcgggccg
    11461 gttcgccgct gtcgccggcc tcaccgacga gctggccgcg ctggccgccg gacccggtga
    11521 cgacgacgcc ctgatggcgc aggtcgacgc catgccgagc gacccgcgct cgctgaacat
    11581 cgtgcaggtg ccgccgctgc tgccgtaccg cattccggtc ggcgtcgccg acgaccgggg
    11641 cgacgctcac tgcctggact ggcgcgctct cctcgtcgcc gccggcgagg acggactgcg
    11701 gctgctgcac gcgccgaccg gccggccggt cgtgccggtc ttcccgcaca tgctggccct
    11761 ggacgcgcaa gcgccgccgg tcgcacgctt cctctccgac ctcgccgcgg cccggccccg
    11821 agtgtggtcc ggctgggact gggccggcct cgacgtcctc ccgtacctgc cgcgtgtccg
    11881 ccacggccgc gtgctgacct cgccgcgccg ctggctcgcg ggacgccgcc tgatggacgc
    11941 ggcgcgctcg gcctccacct ccacctggca ggacggcctg cgcgactggc gtcgccgcgg
    12001 ccgcgttccc gaccgtatcc agatcgcgcg caacgaccag atgttcccga tcgatctgcg
    12061 cgaaccgtgg gaccaggacc tgctgcgcgc cgaactgacg gccaaggagc cccggttcca
    12121 gctgtacgag gacctcaccg ccgatggagc cggtctcggc tggaactccg gacacagcac
    12181 cgagatcgtc gttccgctcg tccgcgccgc acgcgccacc gccgcagccg ggccgcggga
    12241 ggacgcgccg ccgctcgcca ggtccggcat ccggatctcg ccgaccaccg tccatctgcc
    12301 cggtgaggac tggctgtccg tcaagctgta cgcgcagaag gccgcgcacg acggtctgct
    12361 cgccgaccac ctgccggcgc tgctggccga ggtcgacgcg gacgtcgacc gctggttctt
    12421 cctgcgctac cgcgatccgg atccgcatct gcggatccgt ctgcacggcg aaccggccgc
    12481 actgcgcgag cgggtcctgc cggcgctgac cgcgttcgtg aggggcctga ccgcgtccgg
    12541 agccgtacgg acgatggtgc tggacgccta ccgcccggag accgaccgct atctcggtgc
    12601 cgccgcgcag gaagccgccg aagggctctt cctcgccgac agccggtccg cgctgatcca
    12661 gctccaggcc cgccgcgccg gtgcggcggc cgtaccggac gaggtcctgg cggccgccgg
    12721 acacgcggtc ctgttggact cgctcggcga ctgggactgg tgcgcctggg cggaccacat
    12781 gttcaccaag gggcccgacc acgagatcta ccagcgccat cgcgcgctcg ccgacctgct
    12841 ggtgcggccc ggagacatgc ccggcgacac cgcacgccgc gccgcccgcg agctgcgcgt
    12901 cccggcgctc acggaggtat ggaccggctc tcccgagcca caggcatacg gaaagctggt
    12961 gctggcggcc tcggaggccg accgcgacga ggccgtgctg tcgctgctgc acatgcggca
    13021 caaccggctc ttcggcatcg accaggccgc cgagtcccgc gcctacgcgg tcctgcgcgg
    13081 agccgcacgc accttcatcg ccgcccgcgc gcacgcggcc cggacgaccg ccacagccga
    13141 caggagcgtc cgatgaccac tctccacgcg gccggtccgc gcgagcgcgc cggcgaggtc
    13201 tccgaacaga tcctggaccg gctggccgat ccggcggcca ccatggccgc gacccggatc
    13261 ccggccgagg catccgagaa cggcgagccg gagaacatct gggccgagat gacgctcggc
    13321 agcggcagtc cggggctggc catcgcgttc agcggcgcgg cccgcaccgg aaccgaccgt
    13381 acggctcgcg cgcacgcgta tctctcggcc gcgacccgtg ccgcgtccac cggtgccacc
    13441 tcggcgagcg gcatcttcaa aggtcccggc gcgctcggct tcgccgtcct gatggcgcac
    13501 cgcactaccg gcggctacat ctccgcgctc gaacggctcg acggctacca gcgcgacctg
    13561 gtccgcacgg cgatgccggc cgtcccggac aacgctccgc tgtccaccat cggccactac
    13621 gaggtggtgc gcggcatgac cggcgtcggc cgctatctgc tggctcgcgc ggagacctgc
    13681 ggcgaggagc tggagaccgt actgacctat ctgacccgcc tcgcacaggg tgaggtggag
    13741 caccgcggtc acaaggtgcc tcggtggtgg gcgctggacg cgccgcggat cggctcggag
    13801 gcagacctgc cggacggtca cctgaacctc ggtatctcac acggagtcgc cggcccgctc
    13861 gctctgctgt cgctcgcgtg gggccagggt gtgcgcgtgc cgggccagcg cgaggccatc
    13921 gagtcggccg ccgcgctgct cacgcactgg gcggtgcgcg acgcctacgg tctctactgg
    13981 ccgccgcacc tgagcctggc cgactggctg gccggtccgg acgccttcac cgcgccggcc
    14041 ggctggccct cctggtgcta cggcgctcct ggcgtctcgc gcggcctcca gctggcgggc
    14101 ctggcgctgg accgcgcgga ctggaccggc accgcgaacg cctccgtcga acggctgctg
    14161 gctctgccga tggagcgttg gggcatcaac gacaacgcgc tgtgccacgg ctgggccgga
    14221 gcgctgcacc agctcggacg gctgaacgaa cacgtcggcg acgaccgcgt cgaggccgtg
    14281 cgcgaccgga tcgcggccga cctggtcgac gccttcgacc cggagctgcc gttcggtttc
    14341 cgcttcacca tgacgaagac accgttcgcg acggacgtct ccggctacct cgacggagcg
    14401 gccggcctgg cactggctct ggactcctac gcgaccggcg gcactccggc ggactgggac
    14461 atgccactgc tgctggcctg aagcgtgttg cggagcggga ctcccgaacg aatcgcggcg
    14521 gcaccggccc tgacccgcca ggacacagcc ttctgcgaca cgtttcaggg agcgttcagg
    14581 taggccagct ccgaatggac ccctgtgtac cggtcgacca gccgccgggc caccgcgacg
    14641 gagtcgacca gtgggtgcag cgcgaaggcc tgcacggccg ccgacctgga cccgctctcc
    14701 gccgcctcca gcaccgcccg ctccacggcc ttcaccgcgg tgacgagacc gacggcgtgg
    14761 tacgggagcg gcgaaacggc caccggatgg gccccgttgg cgtcgaccag gcagggcacc
    14821 tccaccacgg catcggcgtc cagcaccgaa agggccgtgc ggttgcggac gttgaggatc
    14881 agcgaggtgc gttcgttgcg ggcgacggcc cgcatcagcg cgagggccac ctgttcgtag
    14941 ccgccggact ccagatcgct ctcctcccgc tcccccgccc cggcgacgtc ccggttctcc
    15001 gccatgtacg tggcctcgcg ctcggcgcgg gtacggtccc aggtggccag agccggggtg
    15061 ccgggctccc gcatccgggc gtagaacccc tcctgctggt cgcggaggaa ggcgccccgg
    15121 gtctgctcgg cctcctggta ggagcggacg gcctcgcggt tgaagtagta gtagtgcagg
    15181 tactcgttgg ggatcgcgcc cagcgaccgg aggagatcgg tgccgaagag gcggccctcc
    15241 tcgaaggagc ccagcagctc aggatccgcg agcagccggg gcagttcgtc ccggccgtcg
    15301 acgtacaggc cccgcaccca gccgaggtgg ttgagtccgg cgtagtcgat ccaggcccgg
    15361 tcggggtcgg cgcccaggac ccgggcgata cgcctcccga gaccgaccgg ggagtcgcag
    15421 atgccgatga cgcggtcgcc gaggtggcgg gacatggcct cggtgaccag cccggccggg
    15481 ttggtgaagt tgatggtcca ggcgtgcggg gcgagccggg cgatgcgccg ggccaggtcg
    15541 acggcgacgg ggacggtgcg cagcccgtac gcgatgcctc cggcaccgac cgtctcctgg
    15601 ccgagcacgc cgaggtccag ggcgacccgt tcgtcggcgg cccggccggc gaggcccccg
    15661 acgcggatcg cggagaagac gaagtcggcg ccgcgcaacg cctcgtccag ctcggtggtg
    15721 gcgacgacgg cgggcgcgtc cgggacgccc cgcgcctgtt cctccaggac ccgcgcgacg
    15781 gctgtgagcc ggtcggcgtc ggtgtcgtac agggtgaccc tggtgacgcg gccctcggcg
    15841 tgatcgccga gcagggcccc gtacacgaga ggcacccgga atccgccacc gccaagaatt
    15901 gtcagcttca cgctgctcga tggtacgggg gtgcgccccg cgcacgtcgg cggcggcacc
    15961 ggagcccgcg ttcgggtccg gtgccgccgc cgcaacgggt cagtagccgt tccaccagcg
    16021 ggagacggcc tgccagagcc gcgcgggcgc ggccgggcgg cgctgctgcg ggaccacggc
    16081 ggctcccggc gccggcgcga cgggcgccgg ggcaggggcg tcggcaggag caggggcctg
    16141 ccggggctgc ggcgccgcgc ccggggcgtg ggcgggctgc gtcccggcga gggagtgcgc
    16201 gggctcgggg acgggacggg cgggcgagga gatctcccag tcacccgtcg gacggacggc
    16261 gcgggccatc accgagagcg ggtcggagtc cagcttctgc tgcgggctgg gggcgaactt
    16321 caccggcagc tccaccaggt ggcgggacat gatgttgccg acccagcgca gctcgctctc
    16381 ctccacgccg agctccaggt ccggcagacg catcagcagc gcgtcgacgc ccacgtccgc
    16441 gatcgcccgg ccgatgtcct ggccggggca ctcgtgcggg ccgccgctga acgccaggtg
    16501 ggcgcggttg ccctccatgt tggcggtgag gtcggggcgg accgtggggt cggtgttggc
    16561 cggggcgatg ccgacgagca gggcgtcgcc cgccttgatc tgctggccgc ccagctcggt
    16621 gtcgccgacc gcccaccggc cgaagacggc ggtgaagggg ggctcgtccc agagggtctg
    16681 ctccaccgcc tcgggcacgg tcatatggcc gccgctgagc cgggcgcgga agcgcgggtc
    16741 ggtgaggacc atgcgcagca cgttggcgat gaggttggcg gtggactcgt acgcggcgat
    16801 gaggatgagg cgcaggtgct ccacgacctc gatgtcggtc atcgtggcgg ggtgctcgac
    16861 cagccaggag gcgaagtcgg gggccggttc ggcgcggcgg cgctccacca gccgcgtcag
    16921 cacggcgacg atgtgggcgt tgctggccac ggcggtctcg gtgccgcggg tcatgtcgcg
    16981 ggccgcctgg acgagccgct cgtcgtactc ctcgggcatc ccgaagatcg cgcacatcac
    17041 catcatcggc agatgatccg cgaactgggt gaccaggtcg gcgctgccct tctcggagaa
    17101 gtcgttgacc aggcggttgc tgaagcggtt gatgtggcgg cgcaccccgc gggtgtcgat
    17161 gcgctccatg ctgtcggtga ccgcgccgcg ctgccgctcg tgcttggcgc cgtcggcgaa
    17221 gacgcagacg ggctgccagg tgaagatcgg ggcgagcggg tggtccgggg cgacgctgcc
    17281 gtcctggagg gcccgccagc gccgggagtc ccgggagaac tgggaggggg tccgggtgag
    17341 gtggaggttc tcgctgtggc cgaggacgag ccaggcgggt acgtcgccgt ggagcaggac
    17401 cggggcgacc gtgccgtgtt cggcgcggag cttgtcgtag aggccggcgg ggtcgttctc
    17461 cgcctcgggg ccgtacagcc ggcgcagacc gccggggccg gtgccgaggt tgtgggccgg
    17521 gcactggggc ggcggggcgg cgccgggctc gtggtggaag ggggttgtca cagtggctcc
    17581 agggatcagg acggccaagg ggcgagcgca ggtgggcagg gtgtacaagg gggcgcgccg
    17641 ggggaacggc gcgcgctccc ggcctcggga cggccgggaa ccgtcccggg gccgacgggg
    17701 caccgggcga gcgggagcgg ccggaaccgc tcccacggga cggggcgagg cgaacggccg
    17761 gaaccgctcc cacggcccgt caggcgagcg ggacggccag gctgtgcaga tagcgcatga
    17821 gggtcatcag cacatcgcgg ctggaggccc gcagccgggc gtcgcagtcg atcatcggga
    17881 cctcgtccgg caggtcgagg gctctgcgca gggcctcgac cgggtggtgc ggtgcgtcgg
    17941 ggaaggtgtt gacggccacc acgaacggca ctccgcgctc ctccagccgg ccgatgacgt
    18001 cgaagctgac ctccagccgc cgggtgtcga tgaggacgac ggcgccgagg gctccttcga
    18061 agaggccgtt ccacaggaac cagaagcgtt cctggccggg ggtgccgaag aggtagagga
    18121 tcagctcctc gctgaggctg atccggccga agtccatggc gacggtggtg gcggtcttcg
    18181 tctccacccc ggcgttgtcg tccacgccga cgccggcctg ggtcatggtc tcttcggtcg
    18241 tcaggggccg gatctcgctg accgagccga ccatggtcgt cttgccgacg ccgaacccgc
    18301 cgacgatcac gaccttcacc gcggcggtgg ccgtggtggg gaggacgtcc tcggtgcggg
    18361 gtccggtgat cgtgtcagag cttctgaagt ccatgcatca ccgcttcgag aagggacctg
    18421 tcggggagtg tggcgcggac gatcggcgct cgcgactcga tgagttcggt cgcgaggaga
    18481 tcgctcagga gcgaggtgac cacgctgaac ggcaggctga ggtaggcgga gatctcggcg
    18541 accgataaag gcgcctgaca gagccgcagg atcgcggcct gctccggctg gaacgtcggc
    18601 gagggctcgg cctgcgcgac gaccatcgtg accaggtcga gcgcggcgcg ctcgctgtcg
    18661 tcgagatcgc cggtgatcac gtacagccgt tccggatcgc tgagcgccgg atcggtcttg
    18721 cggcgttctc gtcggggtcc gctcatccgg actgcccgcc gtggcggggc ggactggtca
    18781 ggtgggcgcc gatccgcacg accatgtccc gcatccgggc gccgaccagg ccggcgtcca
    18841 cggtctcgcc cgcgagcacg gcgagatacg caccggtccc ggccgccatc aggtagaaga
    18901 atccgccggt gacctcgatg acgacgagct tcatcaggcc gtcgctgtaa gggatctcgg
    18961 tggccacggc ggccgccagg ctctgcagcc cggcgcaggc cgccgccagc cggtcggcga
    19021 catcggggtc gccgccgtgc atggcgatgc gcagcccgtc cgaggagagc accacgatct
    19081 ggtggatgct cggcacgtcg tcggccagtt ccttgagcat ccagtccatg tttccccgct
    19141 gctggatcac ttcaggtctc ccttgtccca cgcgtcatcg gagtcttcgc cgtgcttcgg
    19201 ttcctgcggt acgccgttga cggccttggt gaaggcctcc agccagaggc cggggggctt
    19261 ctcgccggag ccgccgggcc cgccgggtcc ggcaggcgcg ccgtacccgc cgtcggggtg
    19321 tccgccccgg ctcggcaggc ccccgttggc gggggcgggc ggcggcgggg gctgctgcgg
    19381 caggttgtgc gagccgagcg gggcgcggcc ccggctgcgg cgctgcggca gtccgttctc
    19441 ggtccactcg gtgaccaccg ggacgtcgtc ctccatggcc gcggcgggcg tggccggacg
    19501 ggcggccgcg gcgggggcac cggccggggc cggtgcgacc accgagggca ccgggccggt
    19561 ggcggcgggc ttgggcttgg acttgcgctt tccgggcggc ggcaccacgt gctggagctg
    19621 cgacatgtcc agcgagctgg tgggccgcga ggtggcgccg atgccgtggg cgatgcccgg
    19681 ggcgggtccg gtggtgatca tgtcgcgcgg cacgatgagc accgcgcgga caccgccgta
    19741 cgccgactgg cgcagcgaca cctggagctg gtacatccgc gagaggcgtc cgacgacggc
    19801 catgccgagc cgcggggact ccccgaggtc gttcatgttg atgccggcct gggcctgggc
    19861 gagcatgttc tcggcccggg cgcgggcctc ctcgctgagg ctgacgccgc cgtcctcgat
    19921 ctcgatggcg atacccgtct gcacctcgac cgcggtgacg tgcacccggg tctggggagg
    19981 ggagtagcgg gtcgcgttgt cgaggagttc ggcgcaggcg tggatgagcg gctcgaccga
    20041 ggtgccgacg atggcgacct tggcgatcga gtgcagatcg acgcgctggt actccaggat
    20101 gcgggacata gcaccgcgca acacgctgaa cagcggtacg ggcttgggcc actggcggct
    20161 ggggcgggcc ccgccgagga cggcgatgga gtcggcgagc cggccgatca gcgcggtgcc
    20221 gtggtcgatg cggagcaggt cgtcgaagac ctcggggttg cgcccgtagt ggtcctccat
    20281 ctcccgcagc tcgctggcct ggcggtgcac gatggcctgg acgcggcggg cgacgctgac
    20341 gaaggcgcgc tgcgcggagt cacgccgggc ctcctcgttg tcgatgactt cgaggacctg
    20401 gtagatctgc tcgcgcagcg ccttgggcag atgccggttg gcggcgtccg cgtcgacgat
    20461 gtcgcgcatg acctcctcgg gcgaattgcc cacgcgcaga cgcctgatgg cggcgggcat
    20521 gacctccttg gtgagccgca cggtctcgga gtcatggctg aggatgcggt gttccaggta
    20581 ggcgatgcgc tgttcgtact ccgcgcgctg ggcggccatg gcgcgcctgc ggcggtgcag
    20641 cgccacggtg agcacggcga ccacgagcgt ggtgatcgcg ccgcacacgg cgactggtat
    20701 ccgcgcggcc gggaccacca gggccacgcc ggcggcggtg gcgccggcca gcaggaccac
    20761 gggcggcagg actacgcgga cgacggggac ttctctgtcg gtcggcggtg attcaacacg
    20821 gaccatctaa aaccctctgg cggttgattc cgggatgtat acgcacgtga gcggagactc
    20881 aggaacaagt gctcgaattc gcatcaactc gacttcactg cgcgtgagct tagccagatc
    20941 agaacagggg atcggcatat tcacccaacc ccctgcggga gcccgcgaag aggaatacac
    21001 tcgccagttt tcccactcac cgctgtggag cgtgcgcgag gagtgacgac ggcggaaaag
    21061 gggctatgcc tcaccctcca cgtcccggct gacgggacga aatcgatcca gggataggtg
    21121 atacccggtc aattcgcctg tccagtgctt gatttcgtac cgcagaacag gacaaaggca
    21181 caggtgatcg aaccggatcg aaaggagcag attcctgaac actcggcggg tgacccggaa
    21241 aatcactgtg ctgacgcgta tacgaccgca gattccacgg acctccgaag cggcccgcgc
    21301 gggcggcccc gcagcggaga tcatggcggt cggcgccacc ccgcgggggc gtcggcgggt
    21361 acccggagtg acgacgacag ggagcgggcg gaagcatgac ggcgacaggt gactacacga
    21421 tcgcttcgct ggatacgggg ctccgcgcga tgcggctctt cctcacccat gacaccctca
    21481 ccgtcaccga ggccgccggg cacctccgcg tcggacggtc caccgcgcac cgtgtcctga
    21541 gcaccctgga gagccggggg ttcgccatcc gggacacgtc cgggcgcggc tacgcggcgg
    21601 gcccggagct ggtgcggctc ggccggcccg ccggtttcgg ccgcgcggcc cgcgaccggc
    21661 tggggccggt gctggaggac gcggccgggc ggaccgggga gacggtgtgg agcgtggcgc
    21721 tcatcggcga ccaggtcatc gtcacggacg ggcgtgagtc gccccatccg gtgcgggtgg
    21781 ccctggagtt ggggcggacc ggcccggccc acgcgggctc gggcgggctg ctgctgctct
    21841 cccgtatgac ggcggaccag gtgtgcgcgc tgtacccgga cgaggcgctg gaggcggtca
    21901 ccccggccac gctcacctcg cggacggctc tgctggacga gctggcggtg atccggcgga
    21961 ggggccacgc cgtcagccgg ggcgcctccg tcccgggcat gaccacggtc gccgtcgccc
    22021 tggccgggtc gagctggcgg gaccggctcg ccctggtggc ggctgctccg gcggaccggt
    22081 cgggcgacgc ggcgctcgcc gaacgggcgg agcggctacg ggagtcggcg gcgctgctgg
    22141 cccccgcacc gccggcctga cccggcgtga ccggcggcgt acgcagccct cagcgccgcg
    22201 ctccgccgat ccgcccctcc agctgcacca gcaactcact gagccgggag ccgagttcgc
    22261 cacggcttcc gtcgtcgagc cccgagagca ccgcccgctc gtacgcgagc tgttcgggca
    22321 gcagccggtc gaccagggcg cggccctcgt cggtgaggcg gacatgggcg acccgccggt
    22381 cgcgctcgtc gccccggcgg tccaccaggc cgcgttcctg gagggcccgc agccgcttgg
    22441 tgacggcggc gccggaggag aaggtctccc tggcgagctc gcccggtgtg agttcccggg
    22501 cggtacggcg gacagcaccg aggaggtcga actcggggcg ggtcagcccg gcggagcgca
    22561 gcggggcgtc ctccgcctgc tggagcaggg cggcgcagcg gttgatccgg ccgatgatct
    22621 ccatcgggcc ggtgtcgagc tcgggatcga cggcctgcca ctgccgcacc accaaggcca
    22681 cgatgtcgtc ggtcacgccg ctccgttcgc cggggcaggg gccaccgcgc cgctccgcgt
    22741 gtccggggcg cggaccggcg ggccctgccg ttgtgctgtc gcggcgagcg tacggtgtcc
    22801 ggcccgctca gccgcgagaa gccgctgctc gggcagggcg cgctgccacc actcccccgc
    22861 cgcgatgtcg gcggcctcgc gcagttcgac gaggcgcgcg gtcagcgcgc ggcgcgcccg
    22921 gtcgagcccg tcggggccgg tgtgcgcccg gtccgcgtac gccctttcgg cagcggcccg
    22981 ggcctgtgcg gcggcttcga gggcacgctc gacgcggccc gccgccctcc ggttggtgac
    23041 gagcgccgcc gcgaggaacc cggcgagcgc gccgaggacg gtgtccagga cccggtcgcc
    23101 gaccagttcc ccggccgggt gggtaccgcc gaactccagg accaggaggg ccatcggggt
    23161 gacggcgacg gagccgagcc agtagttccg ggtgatcagg gcctcggcgg cgaagctgaa
    23221 gaagaggcag cacaggacga gcgcgagcgg gccggtgcgg gagagcggca ggacggcggc
    23281 gaagaccagg acgccgagga ggttaccgag ggtgcgctgg agggtccggt tccaggtgag
    23341 ggtggtgttg gcctggtaga gggacgcggc ggtgacgatg gcccagtagg ggcggccgac
    23401 gccgagggcg gcgcagaggt agccggcgag cgcgcagccg atcagcgtac gggcggccac
    23461 gggcagcagg tgcgatccgg ggccgaggct gcgcagcagc gtgcgacggg cggcgcggcg
    23521 gccaccggag gcgcgcaggg cggcccgctc ggcgtcgatc ccgtacagct cggcggccgt
    23581 gccgggtgcg ggcggtggtt cggggacggg tccccgggcg cgggtcaggg cggcccaggc
    23641 gcgcagccgg tccgggtcct ggtccggctg cgcggaggcg ccggccgcct cggcgtgcac
    23701 caccagccgt tccagggagc gccgtacggg ggtgggccgg ccggaggcga gcaggcactg
    23761 ccaggcggcg tgcacggcgg cggccgcggt gtggcgcgta cggggtccgg gttcggccac
    23821 gcggtcggcg gcggcttcga gggcgcgggc gaccgcgcgg cgctcgggcc cctcacggcg
    23881 gatcagcgcg ggccccacac agacgagcca ggccaccgca cccgcgccca gggtcagcgc
    23941 gaggtgggcc gggacctggc cgaggcgctg cggtgcgaac agtgcggcgg agctgacgaa
    24001 ggtgaggatc acgtggccgg gcgggccgat ccggaccgcg tcgcacgccg ccttctgcgc
    24061 ggcggcgagg agcgcgccca ccgcgacgag cacggcggtg gagtgtgtga gcgaggcggt
    24121 gaccagggcg gccgcgagcc cggcggccat ggagagcacg acgcccgcca gggtgcgggc
    24181 ccgccgggcg tacggcaggc cgtggccgta cagcgcgcag agcgaaccgg ccatcgtgta
    24241 catcacgagg tcgagccggc cgagggccag gagcgtcaga tgcggtacgg cggaggcggc
    24301 gacgacgctc agcgcgggct tgaaccaggt gtccgagggg cggttgagac gcagtggggc
    24361 ggccagcggg aggccgcggg cgaacggctg ccggggccgg ggggctgcat cactgggtgt
    24421 atcactcacc catatacgtt aacaggtatt acacctgtaa acgatttacc ccctgtcgca
    24481 c
//
