LOCUS       NZ_KB890946            25444 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. CcalMP-8W B053DRAFT_scaffold_5.6, whole genome
            shotgun sequence.
ACCESSION   NZ_KB890946
VERSION     NZ_KB890946.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. CcalMP-8W
  ORGANISM  Streptomyces sp. CcalMP-8W
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 464790)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   2  (bases 1 to 464790)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. CcalMP-8W
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:14:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,603
            CDSs (total)                      :: 6,529
            Genes (coding)                    :: 6,424
            CDSs (with protein)               :: 6,424
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 83 of 105
            Pseudo Genes (internal stop)      :: 5 of 105
            Pseudo Genes (multiple problems)  :: 18 of 105
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:04:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 350510
            Orig. end                         :: 375954
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB890946.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405361
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25444
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25444
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25444
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15444](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15444
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    620..634
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 20.13"
                     /tool="antismash"
     misc_feature    700..714
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
     misc_feature    complement(931..945)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    1190..1203
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.13"
                     /tool="antismash"
     gene            complement(1709..2059)
                     /locus_tag="B053_RS0126975"
     CDS             complement(1709..2059)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015036989.1"
                     /locus_tag="B053_RS0126975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypco2 family protein"
                     /protein_id="WP_018491710.1"
                     /transl_table=11
                     /translation="MRDPLENVELTAAVQGLRDQLMDAVHAADGQRVRFEVDEITLDFS
                     VELRRDATAKAGFKAWVVSSDAQVGVAQSSVHKVSVKLKPKDSANGGPIEIGNQAEVDM
                     GDFGHPSGLREG"
     misc_feature    complement(2488..2501)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(2725..2741)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 24.18"
                     /tool="antismash"
     gene            complement(3181..3711)
                     /locus_tag="B053_RS0126980"
     CDS             complement(3181..3711)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956213.1"
                     /locus_tag="B053_RS0126980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_234018045.1"
                     /transl_table=11
                     /translation="MGDDIDWPKVEAAYGTAFPDDYKKFVERFGNGTIEGAIAVMVPIV
                     TDDPMTRRVSRLPERALSDPAYRRWTEPDDEKRYGVGRILVWGETDSADTLGWITTDTS
                     PGEWPLAVHNRGDAAWTVHHCGMAEFLVRLFRGDFPECPISDSSLVGASGLRFLHYREE
                     EHLAGLGVYPWDD"
     gene            complement(3762..4349)
                     /locus_tag="B053_RS1000000138050"
     CDS             complement(3762..4349)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025298.4"
                     /locus_tag="B053_RS1000000138050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA/RNA non-specific endonuclease"
                     /protein_id="WP_078507803.1"
                     /transl_table=11
                     /translation="MPGAWGGWRNYGPVDPLHGNRATGVEACLDAAFLQADPGTGTKTS
                     AIAPPAYTWAAIFASDQGNRPAKFWRNACHLLGKQLSGDGLRYDNLATCSRSANAAPMD
                     RRDPGQHPNMVFYENQVKDAVDVGQVVHYKVTPKYVGNRVVPVSFRMQARGVNADGSPG
                     IQFDESVENEMYGLCEGRFCTLGREVPEGYRK"
     gene            complement(<5081..5281)
                     /locus_tag="B053_RS1000000137725"
                     /pseudo=""
     CDS             complement(<5081..5281)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03696.1"
                     /locus_tag="B053_RS1000000137725"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSGSTACYPFGRPRARTGSSPALGFQSGYTDPDSGDVSMAARWYE
                     PGTGGFSSRDTWLLDPTASGQR"
     misc_feature    6043..6052
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            6107..7003
                     /locus_tag="B053_RS01000000134695"
     CDS             6107..7003
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969031.1"
                     /locus_tag="B053_RS01000000134695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetyltransferase"
                     /protein_id="WP_050566086.1"
                     /transl_table=11
                     /translation="MPPVLRRTLTSREASRVLRALGVWTPADAPAGSLHPGDVGWLLRH
                     ADATVHLWVDARGDGRTDPRIDTRHDSAAPVAVGFLDGRVLRVTAAPDADLGAVAADAE
                     ELLVPGNDRTDGLPIPGWRPEREEPWLVLSWSPEPVRTRARPVDESDAADRVSIHRSAF
                     PGSKFALKHWETMRSSPAGNLLVEALVRTPDGDPAAAATGWFGGVGRCGLLEPVGTHPD
                     HRGHGYGRDAVRGACAALADRGASAVAVLTPARNEAAVALYRSAGFTVVRENQRWKPPP
                     GGRELLTQPQARGRSAR"
     misc_feature    7304..7319
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.54"
                     /tool="antismash"
     gene            7341..7721
                     /locus_tag="B053_RS01000000134700"
     CDS             7341..7721
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510903.1"
                     /locus_tag="B053_RS01000000134700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="STAS domain-containing protein"
                     /protein_id="WP_026238173.1"
                     /transl_table=11
                     /translation="MPWESRARVHMRQEQGALVVVASGEFDADERDLLPPVWDEADERA
                     LPVTALDLSAVTFADSSLLDALLRASRRHVAARRRLVIIGPLPPSVLQLLTVTRVLEHF
                     EIVDSLTAALGRGTQPGDTTVN"
     gene            8195..8449
                     /locus_tag="B053_RS0127005"
     CDS             8195..8449
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486104.1"
                     /locus_tag="B053_RS0127005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018491716.1"
                     /transl_table=11
                     /translation="MAADSTFVLDVPEGFDDSDEETGVHPVARKLFLGRDNAATFDKAH
                     RWLSLNPVRVADVSWDYLDGEDEPYCLSVYFTFEEPASA"
     misc_feature    9328..9342
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    9479..9492
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.91"
                     /tool="antismash"
     gene            9593..9784
                     /locus_tag="B053_RS0127015"
     CDS             9593..9784
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS0127015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018491718.1"
                     /transl_table=11
                     /translation="MPLIVEDDVEIDLSDLDLDIQAIATGGVSEPMRPAMFTFITCETT
                     GTTGTSCGFTDGCNPMCC"
     gene            10001..13057
                     /locus_tag="B053_RS01000000134705"
     CDS             10001..13057
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="B053_RS01000000134705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_018491719.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.3e-163,
                     bitscore: 538.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-11,
                     bitscore: 39.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.8e-28, bitscore:
                     92.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDNEDIVQYIRELTAQPALREAISVSSRDLAAALRRLDAGEPMN
                     RKRLVRTAISVTRYALRMTGRPTPFGLHSGVAAIATGERTRTGLNGGGTKSVRLDAGWL
                     DHVTRSWLTDPETVRACEVVLNDLCYVRGDRLILPHVRQRDDYKTFGRAIPRSSEELSL
                     RLSPVLAWTVERTARPVPCGQLLTTASEKFPHLGTAALETFFVELVNNEVLLTPLSVPR
                     TDPEHLDTVARVLPPESPAAVQLRTARSALASYADTEVGGGTEAWEQLVVTTSGIHEDA
                     SAAPDVTLRADITATIPSDVTRELEKCASALWEMSPKEGMYEHMRLYRRAFLDRYGQHG
                     AVPLPELIDPHRGLGFPATYLHPRVSRSFDRHQKQADQTGVKERNDYLAALALRGITDP
                     DREVRLSEADVAALTVKDATRPPRSLDLCCQLLASGGESLDSGDYRLVLSPAVGGSAGV
                     LAGRFADLTGSTEPLKSLMKQAEEGDPDTIVAQVGFLPVLPRALNIMQVPDLTEYTIPV
                     GVFADRNDPRVIDWRHLVVAADGDRLRLHWSRTGQEVVPAVPHALSLGLAAPNLVRFLQ
                     DLRFCGDAKVWRPWDWAGSASLPVLPRVRLGRTVLAPLTWRPSRAVREAASEKDGWEAA
                     LAAWRTELRVPDRVNVVHHDRVYTVDLRNAFHREMLRRDLASGDVSLSETALHGDDAYG
                     WLDGHSSEITVPLRRSPSPATGGAGALLDAARVVPRTEHPPGGEWAYVKLHCVPEVHEE
                     IITDRIPALIKEVAGEIDSWFFMRYRDPDHQLRLRLHGDGTAGTAPVWAKLLPFAESLR
                     RSGLIRGFDVAAYEPETLRYGGPEGMALTEQLFCIDSQLAAHQLKLLGRRALELPRNVL
                     MAAQYAVTLDALGDWDWRPWVTRHFPSGSVPPAEKSEVALAARLIARGGSADLLAPHLS
                     PGCRGLLRGIRGTGVELGRLLLPGLDPDTTFTRHDMALISLLHMQHNRLVGIDPANESR
                     TLGLLSQVARAQASRERHESTRGKDGRRG"
     aSDomain        10367..10654
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B053_RS01000000134705_Lanthipeptide_L
                     anB_RRE.1"
                     /evalue="1.10E-12"
                     /identifier="RREFam001.1"
                     /label="B053_RS01000000134705"
                     /locus_tag="B053_RS01000000134705"
                     /protein_end="218"
                     /protein_start="122"
                     /score="39.5"
                     /tool="antismash"
                     /translation="VVLNDLCYVRGDRLILPHVRQRDDYKTFGRAIPRSSEELSLRLSP
                     VLAWTVERTARPVPCGQLLTTASEKFPHLGTAALETFFVELVNNEVLLTPL"
     gene            13050..14366
                     /locus_tag="B053_RS0127025"
     CDS             13050..14366
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="B053_RS0127025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_018491720.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-55, bitscore:
                     183.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEALRPVRRHRDRALSVADAVADRLRDPAALPSVVPFETPGRAA
                     SWEQASLAAGYAGIAMLFSNRAHLSDGADRVAAHRYLAGAAHYLRGGRCTRSFGIFNEV
                     CGLGLSLVLAQQATGGYGKALRSLDAEVASGTERYCDLVGGEPVGPMGRYDVVDGLSGI
                     ARYLLLRNEHPEVLERVLRTLVRLVAPVAHQGATVPGLWATNPPNRNERKHPHLQRSGH
                     LNLGLAHGVTGPLALLSIATAHGVVVEGQHEAIRSLVALMDRFQLEDEYGIYWPNFISL
                     DEWKAGRCTPRRARVSWCYGAPGVSRALQLAGRAMGNSAWLRTADASVEAVLALPRDRW
                     SVDHWSLCHGWSGAMHVLGYFADGPLGERVERTVDEMADQLLGGLERTGLPEFWLGEEK
                     FPPGTEPAGFLEGAAGLALVLDSYAHGPALPWDMALLLR"
     gene            14383..15444
                     /locus_tag="B053_RS01000000134710"
     CDS             14383..15444
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="B053_RS01000000134710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_018491721.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-14, bitscore:
                     47.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTTRNPAGDPPSLAEQLVPVGDERITVPEFLRRTADLLEGAGT
                     REAGDPAGAGGSARAEDLARLADVFLGAGVPALREAHRDPGWVEFRVSVVEDRRRAWYA
                     ALLGEVRALRDSGDVANFFFVHKQPGFRIRFEVGSRKREPVALRLRRWLAERRAEGVVT
                     EWGPAVYEPEQHLFGGPASMRSVHRLFTADSLVWLEYHSADAPAGPSWALALLQLKSLF
                     GELQVHDYEDRDIWDRLRGQAHRRFPAGEPKDWTRISHDLRRLWHSPEALHPLVGPVSL
                     ALTEEFRRLAHEECEVWRRQHFLASGATVGVREAAAFFTVFLWNRARVSLDVQIATSEA
                     LVLGPPYPMKEES"
     gene            15441..16220
                     /locus_tag="B053_RS0127035"
     CDS             15441..16220
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="B053_RS0127035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_018491722.1"
                     /transl_table=11
                     /translation="MTQAAERAEPVPGDAFGDLLRECWAAGGGLRTVREVLERDDGLLV
                     HADAGNYFTPVEMWPDVDRELLNRVRGPVLDVGCGAGRVLHALRERGVEALGIDTSPGA
                     VRMCRDRGLRAEQASVDDLGSLTETFDTIIMTGNGLGLLQSRERGPAVLRELARVANPG
                     AVILGTSIDPVHLGGPEDPYRRRQASRGLLPGQWRMRVRHGDSATEWFDYVFLSVDDLS
                     ELVAASPWTVRGIHQGASTYLAELAWEGPGTESRSAG"
     gene            16545..18014
                     /locus_tag="B053_RS0127040"
     CDS             16545..18014
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514446.1"
                     /locus_tag="B053_RS0127040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_018491723.1"
                     /sec_met_domain="Aldedh (E-value: 3.7e-167, bitscore:
                     551.0, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPELFIGGRWTAAADGGTREIRCPADGTPVATVDEGGPEDARAAV
                     AAARLAFDEGPWPRTPAAERGRLLLRVAELLERDKDTFARAESLDTGKRMVESAYDMDD
                     IADCFRYFGNLVSAGSTDRVVDTGTADVDSRIVYEPVGVCSLITPWNYPLLQTAWKVAP
                     ALAAGNTFVLKPSELTPHTAVLLMGLLVEAELPEGVANLVLGTGAAVGAPLTEDPRVDM
                     VSFTGGLATGRAVMAAAGPTVKKVALELGGKNPNIVFADADFDTAVDYALMAVFLHAGQ
                     VCSAGARLLVQDELHDRFVDELVARAGRIRLGGPFDEDARGGPLISAAHRDKVEAYVAE
                     GIAEGAVLRCGGARPDDPALADGFYYPPTVLDECRSAMSVVRDESFGPVLTVERFRDED
                     EAVRLANGTVYGLAGAVWTRDAGRAHRVAARLRAGTVWINDFHPYVPQAEWGGMKQSGF
                     GRELGPTGLAEYQEAKHIWRNVATVPQRWFE"
     gene            18011..19603
                     /locus_tag="B053_RS0127045"
     CDS             18011..19603
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019764168.1"
                     /locus_tag="B053_RS0127045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="APC family permease"
                     /protein_id="WP_018491724.1"
                     /transl_table=11
                     /translation="MSRTEGSGGAEGPGGPRGRTVDSSRDDAALGELGYRPELKRTLGN
                     FHTFAAGISYISILTGTFQLFYFGVTFGGPAYWWSWPMVFCGQLMVALCFCELAARYPV
                     AGSVYNWAKKMGGPHVGWLGGWMMMTATMVTLSAVALAYQITLPQIDGWFQFVGDGSGQ
                     NDQAANAVLLGTVLILFSTLVNAFGVKLMARINSAGVFIELIAAVALIVFLAAHITRGP
                     STALTETYGLGGGTGLGYLGAFLTASLASAYVMYGFDTASSLGEESHDPGRNAPRAILR
                     ALIASFLIGAFILLFALLSVPDLKAEELSTGGLQYVVLATLGETVGEIFLWAVVVAITV
                     CVLAVQAAGIRLMFAMARDNNLPAGSKLARVSPRFRTPVVPAVVIGVVGVVILVVNINQ
                     PQIFSVITSIAIIMIYVAYLMVTVPMLLRRLRGTWQPREGAFSLGRWGLPVNVLAVLWG
                     TAMALNLAWPRAEVYNATGPQHWYLRWGAFLFIGVVALGGFAYYWFVQRHRTGVLAEHR
                     SQPADPAVPPSRP"
     gene            19675..21234
                     /locus_tag="B053_RS0127050"
     CDS             19675..21234
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612105.1"
                     /locus_tag="B053_RS0127050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GMC oxidoreductase"
                     /protein_id="WP_026238175.1"
                     /transl_table=11
                     /translation="MPEESPVTAYDYVVVGGGTAGAVVAARLSEDPDTTVCVLEAGPSD
                     VGDDSVLRLDRWMALLESGYDWDYPVEPQEYGNSFMRHARAKVLGGCSSHNSCIAFWAP
                     AEDLDEWGALGCTGWSAAECFPLYRRLETNDAPGDHHGRSGPVTIRTVPPADPCGRALL
                     EACAESGIPTTPFNTGSTVVRGAHWFQINAREDGTRASASVSYLHPVLGKRPNLEVRTG
                     LQAKRLLFEGERCAGVEYLEPDTVHSGRVRARREVVVACGAIDSPKLLMLSGIGPAEHL
                     RESGVEVRVDSPGVGSHLQDHPEGVIMWEAKRPMVTASTQWWEIGVFADTEPGLDRPDL
                     MFHYGSVPFDLNTYRRGYPTSENAFCLTPNVTRARSRGTVRLRSRDFRDKPRVDPRYFT
                     DEHDVRVMTYGLRLAREIVARPAMADWAGTELAPGPGATTDAELFAYIRETHNTVYHPA
                     GTVRMGPADDPDSPLDPQLRVKGVTGLRVADASVMPVLTTANPCITTMMIGEKCADLIR
                     GK"
     misc_feature    complement(21289..21304)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.57"
                     /tool="antismash"
     gene            21325..21954
                     /locus_tag="B053_RS0127055"
     CDS             21325..21954
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003965585.1"
                     /locus_tag="B053_RS0127055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha-ketoglutarate-dependent dioxygenase AlkB"
                     /protein_id="WP_018491726.1"
                     /transl_table=11
                     /translation="MALHLQTSLFDQTDEVAVRPLDGVRREQLGDGAWIDVFPQWLQGA
                     DALFEALVRDVAWRAEERVMYERVVAVPRLLAFFGRRDPLPHPALETVRTALGAHYGAE
                     LGEPFTTAGLCLYRDGRDGVAWHGDTGGRGSTEDTMVAILSLGAPRHLALRPRRPGPVP
                     VRRPLGHGDLIVMGGSCQRTWEHAVPKTARVVGPRISVQFRPDGVR"
     misc_feature    complement(21353..21368)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.19"
                     /tool="antismash"
     gene            22114..24654
                     /locus_tag="B053_RS0127060"
     CDS             22114..24654
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514442.1"
                     /locus_tag="B053_RS0127060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_018491727.1"
                     /transl_table=11
                     /translation="MSATRAADAADFRGPLDISRAATVVLDGRDTVVGWSPAATALLGY
                     SPREAAGRPLSAFLGPPPAEGALPAGGGALPAAADRPSAAGAPAPSGSPARPGPGPPPT
                     GHEIRLARHRDGHELLVVTALCPLAGAGDGGAPGRVLVAAELGGLRQWESRLALLQGLA
                     TQSPVGLAIYDTDLRLTWSNTAYEREIGKPLAEYLGKRADELYSGGRFVTPGYPPTLDA
                     VMHHVIDTGEPVLDLHFQGIPPSDPGTEHLWSCSYYRLEDAQGHVFGVCEDSFDISDRQ
                     RAQRRLALLVEVGRRIGTVLDVVTTAEEIAEVTVPEFAAAVRVDIARVTVMSGELPATG
                     GSAAMDLLRVGEHSVDPAAADAAEPLRPGAPGDPADRYPPVAYPPGSPQDRSLASGGLV
                     LDDNVLVVPLRVGGSVLGLVTFVRSPRPRVSGRPLAHGPATTFDNGEVALADELAGRAA
                     VCIDNARRFTRERSASLALQRQLLPHHVPPQSAVDIAHRYLPSDDVTGVGGDWFDVIPL
                     SGTRVGLVVGDVVGHGLQAAATMGRLRTSVRAFAQLDMAPDELLTRLDDLVGQPGVPQG
                     PPSDAYDELTTGATCLYAVYDPVSRRCVMARAGHLPPAVVHPDGRVTFPDLPAGPPLGL
                     GGLPFESLEIELPVGSLLALFTDGLVEARDHDIDQGLAALGRVLGTPAASLDELCDRAV
                     SALVPDATTADDTALLLARTRQLDGSRVAEWELPAEAVAVGRARELATGRLAAWGLEEL
                     SFATELVVSELVTNAVRYGGGPLRLRLIRDRTLLCEVADTGHTSPHLRHSAEDDEGGRG
                     LFIVAQLVQRWGTRYTPAGKTIWTEQAFPPAEFG"
     misc_feature    complement(24688..24701)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.8"
                     /tool="antismash"
     misc_feature    complement(24716..24734)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 27.42"
                     /tool="antismash"
     gene            24788..25327
                     /locus_tag="B053_RS0127065"
     CDS             24788..25327
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612101.1"
                     /locus_tag="B053_RS0127065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018491728.1"
                     /transl_table=11
                     /translation="MSAVPSTRTVARTGLALFSAAALALTLSSPAAAATGTRTITDGGT
                     TYNLSLTAPDTANAAGQNITVTGSGYNTLQGVYVSLCVVDGAQGANKPSPCLGGQDESG
                     TTGASHWVSNLGGGVLPNSSAFGTGGTFSVQIHVKADLGGGNICGDTVECAVVTRADHT
                     DTNDRKYDVHTPIDFV"
ORIGIN
        1 gcctcgtccc acacctgtcc cgggagctca ctcggccggg acattcgcgc ggtgtcggac
       61 acgaggtagt cgaacggctt ccacgttcct ccccggcccg gtaccagggg gctggtgacg
      121 ccaagcacga tcctggacgc ccaatcccag gcttcctcca tgccttccgg ccgcaacgcc
      181 gggccgcccg cccggtcgag gaagtgcgcg tggaggcgct ccagggactc cggcggcagc
      241 gcggtgtcca cacctgtgcg ggcgagggcg acagcggctg cgacgagcgc ggcgccccgg
      301 gggttgcctt tcgcccggga agcggccttc caccgcttga ggacctgcgg tccggccgca
      361 aggtactccg ccactccgtg cgccctgtcg gcgttcagtg ccgcaacgac acgcggatcc
      421 tcgcccgacg acgcagccga ccgctcgtct tcggtccaga tccggtccag ggtgatgtga
      481 tgcgctgcgc ggatcactct gcccggcgag gacggcagtc tcggcccggt gctccgcgac
      541 agcgacgggc cgtcctcctc gtccgtgtaa tgctcgtgga actcggtgcg cagcgtggca
      601 agcacgacca tgccgcgccg gacgaactgg tccagcaggg acggcgtcag cccgtcggac
      661 cgcaggtaat tgtgcaggtc atcgagccat acgaccttct ggtgatcact tccagaggag
      721 gaatgcaggg aggacaggtc tgcgtcgggg tccggcttgc agaccgacca gtccccaaga
      781 ttgcggacca ttccttcgaa cagggctctg gacttgcctg cggccgaatc ccctgtaagc
      841 agcagcatgc cgcccgtttc cgccagcgct tcgagtcggg cgtccacctg cacgtcgacg
      901 cagcgtggca cgtattgcac aacgtccgga tggccgaagg catccggcgc gcgatgaaca
      961 ccgaaggaga ctgggtcggc gtcggcggca gggacccagt cgccttcaca cgatgcggcg
     1021 gcctcgttca ccacctgcgg cgcgggcctg ccgatctcca ccacctcggg acagagtcct
     1081 gctgctgcct ccaccgcccg tcgaaatccg gcatcagcca cgacgacaaa gatgggaacc
     1141 gcttccaccc gcgcgtgacc ccactgtgcg ggatccccag ataccacgcc gatcaaatat
     1201 tcgtcgacga agagcgcggc acccgacatt ccctgccacg gcgatgtgcc ggaggtgccg
     1261 accgcaggcg gcggggcgtg ggaactgtcc aggacatagc ggccgcgcag gacggatgat
     1321 cccggcttca gcgtgcccac gatttgctcg gtgtccggcc gcatgccgtc gcggagcgag
     1381 atccgcgggt agcctaccgc ttcgcagttc tcccaggcgg ccaggccgga aacccgcccc
     1441 caccgaacgt cgagcaaccg gcacgccgtg cctcccctga ccaggtcttc gtccgcttcg
     1501 agcagggctg cgtcgcacga ctcgtcgtag cgacgccaca cgaggcggca gctgtgcgtc
     1561 cctgtccctc cgggtaccgc gacgcgagca acctcaccct ccccatcgaa caggtgcgcc
     1621 gaagtgagca ccaggcggga gtccagcagg aagccgctgc cctgccgcgc tccctgaacg
     1681 atggcgatgc gttcgacgga ccgggtgctc atccctcgcg cagtccggac ggatgcccga
     1741 agtcacccat gtcaacttca gcctgatttc cgatctcgat cggcccgccg ttggccgaat
     1801 ccttaggctt cagctttacg gacaccttat ggacggagct ctgcgccacc cccacctggg
     1861 cgtcgctgga gaccacccat gccttgaacc ccgctttggc cgtcgcgtcg cgccgcagct
     1921 cgaccgagaa gtccagagtg atctcgtcga cctcgaacct gacgcgctgg ccgtccgcgg
     1981 cgtgcacagc gtccatcagc tgatcccgca agccctgtac ggccgccgtg agttccacgt
     2041 tctccaacgg atcgcgcatg tctccgactc ccccattcgg tccaccgtca accgctacca
     2101 ctatcacatt gcccttggca cgaaacggcg atccggacag tgcctccagg cacgacggaa
     2161 cgctgtgtgg tcgcgcagca cccggccgac acccgccagg cttctggcaa accgtgcgat
     2221 ctgcaggtcg tccctgctcc cgcgaggatt gctccactca ggtcgctccc tctacaactg
     2281 cggccgcgtc gtcaccgcgt ccgcagggga ccgcctcatc cggcgcactg catctcgacg
     2341 actacaccat cgacagtctc ctgtgcctgc cccgtcatcc gcgaagaggc ccccaaccgc
     2401 tgagctccag cacgccctgc acagcccgca tgacctggaa aagaacgtct tgtctccttg
     2461 ggagtcctct gggactttcc tgggactttc aactgcatca aggggcacga gcgggaaaca
     2521 gccgaaaggc cattttcgca ggtcagcgac aggtgttcga tcgttcctgc aggtcagctg
     2581 agcgaatggt ctcttccggg acatctgacg ggcggggtgt cgtgcccttg ggcggcacgg
     2641 ggcacgacac ccctcaatgc ctgatggcct gcggccacac cctttctcga ccgtccattg
     2701 atcaccgctg ctcttcatca ccttgtgcaa cgcgtgtgca agatgatctg aatggctaac
     2761 gatgcgtcag gcatgcctga ttgcccgtca ctccttacgg aaagggctca ccagaggggc
     2821 ctcaccatgc ccgcaacgac gccgccactg gcgttcctca aaggcgcagt tcagtcctcg
     2881 ccgcgcccgc atcaagcgca ccacacggct acgttcagtc ccggcccgga cctccacgag
     2941 taccggcgct ccttcgatca tccggctgcc ccggacgtcc agcccggtcc ggctgtgacg
     3001 acgagggccc ggcccgatcg agccgggccc tccgccctgt tgcaggctcc cgtccttcgc
     3061 atgagcgcag gagggacggc caaggccggg cccggggcgc ttatgcctcg ggcccggccg
     3121 ccgttcaaac cacttccggc ccagctcccg ctgcccggcc gaccaacggc ggcatggacg
     3181 tcagtcgtcc cacgggtaca cccccagacc ggccaggtgc tcctcctcac ggtagtggag
     3241 gaagcgaagc cccgaagccc ccacgaggga ggagtcgctg atcgggcact cggggaaatc
     3301 cccgcggaac agccggacga ggaactcagc cataccgcag tggtggaccg tccacgccgc
     3361 gtcgccacgg ttgtggacgg caagaggcca ctccccggga ctggtgtctg tggtgatcca
     3421 tccgagtgtg tcggcgctgt cggtctcacc ccatacgagg atccggccga cgccgtaccg
     3481 cttctcgtcg tcgggctcgg tccagcgccg gtacgcggga tcggagagcg cccgctctgg
     3541 cagtcgactc acccgtcgcg tcatcgggtc gtcggtgacg atcggaacca tgacggcgat
     3601 cgccccctcg atcgtgccgt tcccgaaacg ctcgacgaac ttcttgtagt cgtccggaaa
     3661 ggccgtgccg taggcggcct cgaccttcgg ccagtcgatg tcgtcaccca tgtcgccccc
     3721 gtagggggtg agcacgctgg acagttgccc aatggactct gtcattttct gtagccctcc
     3781 gggacctcac gtccgagagt gcagaagcgt ccttcacaca ggccgtacat ctcgttctcc
     3841 actgactcat cgaactggat gcccgggctg ccgtcggcgt tcactccacg agcctgcata
     3901 cggaagctga ccgggaccac tcgattgccc acgtatttcg gcgtcacctt gtagtggacc
     3961 acctggccca cgtcgacggc atccttcacc tgattctcgt agaacaccat gttggggtgc
     4021 tgcccggggt cgcgccggtc catcggcgcc gcgttggcgg accgtgagca ggtcgccagg
     4081 ttgtcgtagc ggagtccgtc tccgctgagc tgcttcccca gcaggtgaca ggcgttccgc
     4141 cagaacttcg cgggccggtt cccctggtcg gaggcgaaga tcgccgccca ggtgtaagcc
     4201 ggcggagcga tagcggacgt cttggtcccg gtaccaggat cagcctggag gaatgccgcg
     4261 tcgagacacg cctcgacgcc tgtggcccgg ttcccgtgca gagggtcgac cggcccgtag
     4321 ttccgccagc cgccccatgc ccccggcagt cgcccgagtc accgctcgtg ttcccgtcgc
     4381 ccggggcggc gcccggcgcg gggtgaagct caggattctc ctgcgggtcg aagccgcctc
     4441 cgtcaagaag gtccagcatc tggagggctc ccatgacgac gtcccatccg ctgcccggct
     4501 tccaaccgct gcccttgggg tcccagtcgg gccggggagc cggacggtcg ggtacagggc
     4561 ggggcgagga gccgttgttc gggttctgat cgatgggcgg ggccggcggg cggaccggca
     4621 cgcggaccgc cgctacggcg acgccaccac ccccgccgcc accgctgtag cgggtgtagg
     4681 cgcgcgggta gtagcgcggc acgtacctgg tccctcctcc gaccgagctg cggcctccgc
     4741 caaccttcga accgctggcg gcccgggact tggtgcccgt cctgctgaag cgggcggcct
     4801 gggcccggag ggctgcccgg gcccgggcag cggcggacgc cgccgctgcg taggtgtggg
     4861 acagcgcgcc gctgcccgcg taaccactgg acatggcacc ggccttggcc cgctggtgct
     4921 tgtcgatcac cagcgcgccg ccaccgacca ccgtcgtgcc gaagatgccc cggccgagcg
     4981 cgttccagcc gacagctgca ccgagaacca gcgggaagac atgaccactc gggtcggtgc
     5041 cgttcaacgg ggatccgaag ccgtaggagt agcggtttgc gcgttgcccc gaagcagtgg
     5101 gatccagcaa ccaggtgtcc cgggaggaga aaccgcccgt tcccggctcg taccagcggg
     5161 ccgccatgct gacgtccccg ctgtcggggt ccgtgtagcc ggactggaag cccagagcag
     5221 ggctgctacc cgtgcgggcc ctggggcggc cgaacgggta gcaggcggtc gagccggaca
     5281 cctcggtgct gtccgcggac agggctgcga cgacgtcggt gtgccgatcg gtgatcagcc
     5341 gctgggtccg gtcatccgtg gtgccggaga tcagggagcc gccggggctg cgcgtatagc
     5401 gcgtacttcc gtccgagacc aggtcctggg agccgccgtc gtaccggaag gccgtgttcc
     5461 cccgacggat gatccggtcg tcagcccctc gtccacctcc agactgagca gtggagcagc
     5521 atcggcgtac tgggcgaagg cgacggccga tcggggggac cgcggttccc agagctcacc
     5581 cgcgccgttc atgccgctca ggcccgcagg cttggtgatc gtggtgtcga tcgcctccca
     5641 ggtgccctgc gccgtacgga agttgaccgg ctcgttgtag aaccgggtgg tgtacgagcc
     5701 ggccagtctt tgatcatggg tacgcaagtt cgatagcgat cactgaccac ctgccgcccc
     5761 gcgacacggc aagcccgtgc ggccggaccg tctgcaggcc gacctcgtga cgggccggtg
     5821 atctgaccgg cctgcacagc ggcgaggagc gcgagaaggg tgagggagcc gccggagagg
     5881 tcgcgggcag catgcccgcg ctcgggtgga tcagtcggtg gccgcacgcg gcgcctcgtc
     5941 ggggaagcca tgggtatcct catggcccgc cacggcctcg ccgagaacgg agccttcaac
     6001 gtcctgcgcc gccgctccca ggaccggaac gccgaacccc gggaaggcgg ccgacagatg
     6061 cgcggacaag gccgcctccc ccagactcag gaactgacac gcacccatgc ctcctgtact
     6121 gcgtcggacc cttacctcca gagaggcctc ccgggtgctg cgcgccctgg gggtgtggac
     6181 gccggccgac gccccggccg ggagcctgca tcccggagac gtgggatggc tgctgcgcca
     6241 cgcggacgcg acggtccacc tctgggtcga cgcgcgcggc gacggacgga ccgacccccg
     6301 catcgacacc cggcacgact ctgccgcacc cgtcgccgtg ggtttcctcg acgggcgcgt
     6361 gctgcgggtg accgccgcac ccgatgccga tctcggggca gtcgcggcgg acgccgagga
     6421 actgctcgtc cctggcaacg accggaccga cggcctgccc atccctggct ggcggcccga
     6481 acgggaagag ccctggctcg tcctctcctg gtccccggag ccggtgagga cgcgtgctcg
     6541 gccggtcgac gaatccgacg cggcggaccg ggtgtcgatc cacagatcgg ccttccccgg
     6601 ttcgaagttc gccctgaagc actgggagac gatgcggtcg tctccggccg ggaacctgct
     6661 cgtggaggcc ctggtgcgca cgccggacgg tgaccccgcg gccgccgcga ccggctggtt
     6721 cgggggcgtg ggccggtgcg gcctgctcga acccgtcggc acccacccgg accaccgcgg
     6781 ccacggctac ggccgcgacg ccgtgcgggg cgcgtgtgcg gctctcgccg accggggtgc
     6841 gagcgcggtg gccgtcctga ctccggcgag gaacgaggcg gcggtggcgc tctaccgatc
     6901 ggcgggattc acggtcgtac gggagaacca gcgctggaag cccccccccg gcggacgaga
     6961 gctcctgaca cagccacagg caaggggccg ctctgctcgc tgagcgacat tatgtcctcg
     7021 gggcaggttg agggggtgag cgtgatggtc tgctttccgc gcggggtgac cgagatgcac
     7081 cgagccgggc ggcagtccag cggccggccg gaaccgccgc aggtgatccg gctcgtgaaa
     7141 gtggccgacg ccaccatccc gcacaggggc gggatcggca cccgacctcc cgcacgattc
     7201 ccggaaccgt acgggcggcc gtccatggca ggcgccgcct gcctgcctgc ctgcctgtct
     7261 cacagcccag ggcacggttg acatagagtc aacactccgg gccgatggtc tggaccactt
     7321 ctacggagag ggaacgccgg atgccttggg aatcacgggc ccgcgttcac atgcgccagg
     7381 agcagggcgc actggtggtc gtggcctcgg gtgagttcga cgcggatgag cgggatctgc
     7441 tcccgcccgt ctgggacgag gcggacgaac gggccctgcc cgttaccgca ctggacctgt
     7501 ccgccgtcac cttcgcggac agctccctgc tggacgccct gctgagggcg agccgccgcc
     7561 acgtggccgc ccggcgccgc ctcgtcatca tcggccccct cccgcccagc gtcctgcagc
     7621 tcctgaccgt gacccgggtc ctggagcact tcgagatcgt cgactccctg accgcagcac
     7681 tcggcagagg cacgcagccc ggcgacacca ccgtgaactg acccgaggtg tttggcggag
     7741 gggaacgggg acacccgaga acagctcgga acggacctcc gactccaccc acgccgacgg
     7801 gggccgtccc ggcagcggtt cctccggcgt gacgaagtcc gccggaggaa ccagcacccg
     7861 aacgcaggac gcccgggacc ctccgaagag ggtccacggc cggctcccgc acagctcgcc
     7921 ggacgggcat gaacaacgtc atcgcggact gccggacgtc tctctccctc tcacccgccg
     7981 acgccgcggc atgtagccct gcttgccaca gcggtcacgc acccgctgcc gtcggtccga
     8041 acggcacgac cgccaaggag ccggtttcgg tccccggacg agcggcctca cgcatgaagc
     8101 aactctcacg atcggcaggg cgtcctctcc catggcatcc gtgcggagag attctccgcc
     8161 cgcatcggag ccctcagcga aagagggaac gcacatggcg gcagattcca cattcgttct
     8221 ggacgtgccc gagggattcg acgactcgga cgaggagaca ggcgtccatc cggtcgctcg
     8281 caaactcttc ctcggaaggg acaacgcagc gacgttcgac aaggctcaca ggtggctcag
     8341 cctgaatcct gtgcgcgtcg ccgacgtatc ctgggactac ctggatggcg aggacgaacc
     8401 atactgcctg agcgtctact tcaccttcga ggaacccgct tcggcttgat cggacgccgc
     8461 tgctcgacgt tcaggggggg atcgcagcct tcggttggcc gctgggacgg gggaaccgct
     8521 gagccccaag gtcgcagcgg cacggtccgc accatgggac cgtcccgtcg catcgaccgc
     8581 cctgcgccgc accgaggacg ccgtgatgac ctacgcccgg tccggcccgg gtcgttgggc
     8641 cggactgcgt ggacctcggc aaggcggccc tggggctgtg gccggagacg acgttgggcg
     8701 gcgaggaatc cgacaacgcc gaacaccgat gcgtccgcac cagcacccgc acccgtcccg
     8761 gcccaccgtt cggaaccttc tcaacgcgct tgcccgccgg ttccaggccg tgccgtttca
     8821 cctggtcgac gaggcgcctc cactccacga cctcgtcgtc atcagggtcg gtgacccgaa
     8881 cacgaccctt ggcgacgagc cgctcgacag cccttgagcc gtcgcccgcc gagcccgcgc
     8941 cacgagcctc tcgctgcagg gcgtccgggg tccggcgggt acggagacaa ctccgctgcc
     9001 accggcgacc gcggagttgc ctccggccat cagggcccca ccggaccgca aggcaccgga
     9061 cgagcgccag ccactcggca tacaggctcc accgtcctcg ccggaaacga ggccgttcgg
     9121 ctgcccgtcc tgccgtgcag agccgacagg cacccgtgag cgtcgggagt cccccgggac
     9181 ttctccggga attccggccc catcgagcga cacgagcggg aaacagccga tggtcatgcg
     9241 cgcagctcag cgaccccacg ccacccatcg cggcaggcca ccacgttccc tggcccctcc
     9301 cgggacatcc gcatcgtcga atctggctga atttcatatt ccgccgtccc ctgaaccata
     9361 cccagccgga tcggggggcg gcggcgtttc cggaatttcc cccttatctc acttctcggc
     9421 cgggccgcgc ccgatcgccc gcattcgccc tctttcccaa gatcgataac acggcagcat
     9481 tcgaaaataa acccttgacc cttcaggtct gccgtgacac ggttaaatct cttcacccgc
     9541 cggggaatcg aataaggcaa ttcctcgacc aaaagagaga tgggtagcag ccatgccgct
     9601 tatcgttgaa gacgacgtcg aaatcgacct ttccgacctc gatctggaca ttcaggcgat
     9661 cgccaccgga ggcgtgagcg agcccatgcg gcccgccatg ttcaccttca tcacgtgcga
     9721 gaccacgggc accaccggca cctcctgcgg attcaccgac ggttgcaacc cgatgtgttg
     9781 ctgacccgcg gagcctgtga gccgcagccg gtcaccggat gaccgccgcc ggatcgggcc
     9841 cctgacccgg ggcccggtcc ggcggcaccg cctcttctga acgagatgat ctcttatgga
     9901 attgccgagc catttcactg cagccgatcc gattcttctt cgtgtcacat cactgagcaa
     9961 gaattcattc aaggcgacga cggagttcgg ccgcgatgcc atgcccgaca acgaggacat
    10021 agttcagtac atccgggagc tgacggcaca gcccgccctg cgggaggcga tctccgtgtc
    10081 gagccgcgat ctggccgcgg cactgcggcg gctggacgcc ggtgagccga tgaaccggaa
    10141 acgactcgtc cggacggcga tctcggtcac ccgctacgcg ctgcgcatga ccgggcgccc
    10201 cacccccttc ggcctgcact cgggagtggc cgcgatcgcg accggggagc gcacacgcac
    10261 cggtctgaac ggcggcggga ccaagtccgt acggctggat gccgggtggc tcgaccatgt
    10321 gacgcgttcc tggctgacgg atccggagac cgtgcgggcg tgcgaggtcg tgctcaacga
    10381 tctctgctac gtgcgggggg accgcctgat actgccccac gtgcggcaac gggacgacta
    10441 caagaccttc ggccgggcca tcccccggag cagtgaggaa ctttccctgc gcctgtcccc
    10501 ggtcctcgcg tggacggtcg agcgaacggc tcgccccgtc ccctgcggac aactcctcac
    10561 caccgcttcg gagaagttcc cgcacctcgg cacggcggcc ctggagacct ttttcgtcga
    10621 gctcgtgaac aacgaggtgc ttctcactcc gctgtccgtt ccccggaccg atccggaaca
    10681 cctcgacacg gtcgcacgcg tgcttccgcc ggaatcgccg gccgccgtac agctgcgaac
    10741 ggcccgctcc gccctcgcct cgtacgcgga tacggaggtc ggcggcggga ccgaggcgtg
    10801 ggaacagctc gtcgtcacga cctcgggaat acatgaggac gcctccgcgg caccggacgt
    10861 gaccctgcgg gcggacatca cggcgaccat tccgtcggat gtgacccgcg aattggagaa
    10921 gtgcgcttcg gctctctggg agatgtcccc gaaagagggc atgtacgaac acatgaggct
    10981 gtaccgccgg gcctttctcg accggtacgg acagcacggt gccgtgcccc tgcccgagct
    11041 gatcgacccg caccggggac tcggctttcc cgcgacctac ctccacccgc gggtcagccg
    11101 gagtttcgac cgccaccaga agcaggcgga ccagaccggc gtcaaggagc gcaacgacta
    11161 tctggcggcc ctggccctcc gggggatcac cgacccggac cgcgaggtcc gtctcagcga
    11221 ggcggatgtc gccgcgctga cggtgaagga cgcgactcgc ccgccccgct ccctggacct
    11281 ctgctgccaa ctcctggcct ccggcgggga aagcctggac agcggggact accgccttgt
    11341 gctgtccccc gccgtgggcg gttcggcggg agtgctcgcc ggacggttcg cggatctcac
    11401 cggatccacg gaacccctca agtccctcat gaaacaggcg gaggagggcg acccggacac
    11461 catcgtcgcc caggtcggct tcctgcccgt actgccgcgc gccctgaaca tcatgcaggt
    11521 tccggacctc accgaataca ccatcccggt gggagtgttc gccgaccgga acgatccgcg
    11581 ggtcatcgac tggaggcacc tggtcgtcgc ggcggacggc gaccggctgc ggctgcactg
    11641 gtcgcgcacc ggccaggaag tggtaccggc cgtgccccat gccctgtccc tgggcctggc
    11701 cgcccccaac ctggtcagat tcctgcagga tctgcggttc tgcggcgatg ccaaggtctg
    11761 gcggccgtgg gactgggccg gttcggcgag cctgcccgtg ctgccccggg tgagactggg
    11821 caggaccgtg ctcgcacccc tgacctggcg cccgagccgg gcggtgcgcg aagcggcctc
    11881 ggagaaggac ggctgggaag cggcgctggc ggcctggcgt accgaactgc gcgtgccgga
    11941 ccgggtgaac gtcgtccacc atgaccgtgt ctacacggtc gacctccgca atgccttcca
    12001 ccgggagatg ctgcgccgcg acctcgcctc gggggatgtg tcgctgagcg agacggcgct
    12061 ccacggtgac gacgcgtacg gctggctcga cgggcacagc agcgagatca ccgtcccgct
    12121 gcgccggtcg ccgtctcccg ccaccggcgg ggccggagcg cttctcgacg cggcgcgtgt
    12181 ggtcccccgt acggagcacc cgccgggtgg cgagtgggcc tacgtgaagc tgcactgtgt
    12241 accggaagtg catgaggaga tcatcaccga ccggattccg gccctgatca aggaggtggc
    12301 cggtgagatc gacagctggt tcttcatgcg ctaccgggat ccggaccacc agctccggct
    12361 ccggctgcac ggcgacggaa cggcgggcac cgcgcccgta tgggcgaaac tcctcccgtt
    12421 cgcggagtcg ttgcggaggt cgggcctgat ccgcggcttc gacgtggcgg cctacgagcc
    12481 ggagacccta cggtacggcg gtcccgaggg catggccctg accgagcagc tcttctgcat
    12541 cgacagccag ctggcggccc atcagctgaa actgctggga cggcgggccc tggagctgcc
    12601 ccgcaatgtg ctgatggcgg cccagtacgc cgtcacgctc gacgcgttgg gcgactggga
    12661 ctggcgcccc tgggtcaccc ggcacttccc cagcggctct gttccgccgg ccgagaagag
    12721 cgaggtggca ctcgccgccc ggctgatcgc acggggaggc agcgcggatc tcctcgcgcc
    12781 gcacctgtcc cccggctgcc gggggctgtt gcggggaatc cgtgggaccg gcgtggaact
    12841 gggccgtctg ctgctgccgg gcctggaccc cgacacgacg ttcaccaggc acgacatggc
    12901 gttgatcagc ctgctgcaca tgcagcacaa ccgcctcgtg ggcatcgacc cggccaacga
    12961 gagccgcacc ctcggactcc tgtcccaggt ggctcgcgcc caggcgagcc gggaacgcca
    13021 tgagagcacg cgagggaagg acgggcgtcg tggatgaggc cctccgcccc gtgcgcaggc
    13081 accgggacag agccctgagc gtggcggacg cggtcgccga ccggttgcgg gacccggccg
    13141 cgctcccctc cgtcgtcccc ttcgagaccc ccggccgtgc tgcgagctgg gagcaggctt
    13201 ccctggccgc cggatacgcg ggcatcgcca tgctgttcag caacagggcg cacctgtcgg
    13261 acggcgccga ccgggtcgcg gcccaccgct atctggcggg cgcggcccac tacttgcggg
    13321 gcgggcgctg cacgaggagc ttcggcatct tcaacgaggt gtgcggcctc gggctctcgc
    13381 tcgtcctggc ccagcaggcg accgggggct acggcaaggc cctccggtcc ctcgacgcgg
    13441 aggtcgcctc gggtaccgag cgctactgcg atctggtcgg cggcgagccc gtcggtccca
    13501 tgggccgcta cgacgtggtc gacggtctca gcggtatcgc ccggtacctc ctcctgcgga
    13561 acgagcaccc cgaggtcctg gaacgggtgc tccggaccct cgtgcgcctg gtggcccccg
    13621 tggcgcacca gggcgccacg gtcccgggcc tgtgggcgac caatccgccg aaccgcaacg
    13681 agcggaagca cccccacctc cagcggtcgg ggcatctgaa cctgggactg gcccacggag
    13741 tcaccggtcc gctggccctg ctgtccatcg ccacggcgca cggtgtcgtg gtcgaggggc
    13801 agcacgaggc gatccgctcc ctggtcgccc tcatggaccg gttccagctg gaggacgagt
    13861 acgggatcta ctggcccaac ttcatctccc tcgacgagtg gaaagcgggc cgctgcacgc
    13921 cccgacgcgc ccgcgtctcc tggtgctacg gcgctccggg ggtctcccgc gctctgcagc
    13981 tggccgggcg ggccatgggg aacagcgcat ggctgcggac ggcggacgcc tcggtggagg
    14041 ccgtgctggc gctgcccaga gaccgctgga gcgtcgatca ctggtcgctc tgccacgggt
    14101 ggtccggtgc catgcacgtg ctcggatact tcgcggacgg gccgctgggc gagcgcgtcg
    14161 agcggaccgt cgacgagatg gccgaccagt tgctcggcgg cctcgaacgc acggggctgc
    14221 ccgagttctg gctgggagag gagaaattcc cgccgggcac cgaaccggcc ggcttcctgg
    14281 aaggtgccgc cggactggcg ctggtcctcg attcctacgc ccacgggccg gccctgccct
    14341 gggacatggc cctgctgctg cgataacagg aggctgctca ccatggccaa gaccacgcga
    14401 aacccggccg gggacccgcc ctccctcgcg gagcagctcg tgccggtcgg cgacgaacgc
    14461 atcaccgtgc ccgagttcct caggcgcacc gcggaccttc tcgaaggggc cggaacccgt
    14521 gaggccggtg atcccgccgg ggcaggcggg tcggcacggg ccgaggacct ggcgcggctg
    14581 gccgatgtgt tcctcggcgc gggtgtgccg gcgctgcggg aggcgcaccg cgacccgggg
    14641 tgggtcgagt tccgggtctc cgtcgtggag gaccggcgcc gggcctggta cgcggcgctc
    14701 ctcggggagg tgcgagcgct cagggactcc ggggacgtgg cgaacttctt cttcgtgcac
    14761 aagcagcccg gcttccggat caggttcgag gtcggctccc ggaagaggga accggtcgcc
    14821 ctccggctgc ggcgatggct ggcggagcgg cgcgcggagg gcgtcgtcac cgagtggggt
    14881 cccgccgtgt acgaaccgga gcagcacctg ttcggcggac cggcctcgat gcgcagcgtg
    14941 caccggctct tcaccgcgga ctccctggtg tggctggagt accactccgc ggatgctccg
    15001 gccggaccgt cgtgggcgct cgcgctcctt caactgaagt cgctgttcgg cgagttgcag
    15061 gtgcacgact acgaggaccg ggacatctgg gaccggctga ggggccaggc tcaccgccgg
    15121 ttccccgccg gcgaaccgaa ggactggacg cggatctcgc acgatctgcg ccgcctctgg
    15181 cactcccccg aggcgctgca tccgctggtc ggcccggtgt cgctggcgct caccgaagag
    15241 ttccggcgac tcgcccacga ggagtgcgag gtgtggcggc gtcagcactt cctggcctcg
    15301 ggcgcgacgg tcggtgtgcg ggaggcggcc gcgttcttca ccgtcttcct ctggaaccgc
    15361 gcccgggtct cgctggacgt acagatcgcg acgtcggagg ccctggtgct cgggccgccg
    15421 taccccatga aggaggagtc atgacacagg ccgcggaacg ggccgaaccg gtgccgggtg
    15481 acgccttcgg cgatctgctg agggaatgct gggccgcggg gggcgggctg cgtacggtgc
    15541 gcgaggtcct ggagcgggac gacggtctgc tggtccacgc ggacgccggc aactacttca
    15601 cgcccgtgga gatgtggccc gacgtggatc gggagctgct gaaccgcgtc cgtggaccgg
    15661 tcctggacgt ggggtgcggc gccgggcgcg tcctccacgc cctgcgggag aggggggtgg
    15721 aggcgttggg catcgacacc tcacccggcg cggtgcgcat gtgcagggac cgcggtctgc
    15781 gggccgaaca ggccagcgtg gacgatctcg gctccctgac ggagacgttc gacacgatca
    15841 tcatgacggg gaacggcctg gggctgctgc agagccggga gcgcggtccc gccgtcctgc
    15901 gcgagctggc acgggtcgcg aacccgggcg ccgtcatcct cggcaccagc atcgatccgg
    15961 tgcacctggg cggcccggag gacccctacc ggcggcgcca ggcgtcccgc ggcctgcttc
    16021 cgggccagtg gcggatgagg gtgcggcacg gggacagcgc gaccgagtgg ttcgactacg
    16081 tcttcctctc cgtcgacgat ctgagcgagc tggtggcggc ctcgccgtgg acggtgaggg
    16141 gcatccacca gggggcctcg acctatctgg cggagcttgc gtgggagggg cccggaacgg
    16201 agtcgcggtc ggccgggtga tctccacggg cggcggcgga ggccttccgg ccactccgtc
    16261 ggacgcggcc tccggaaggt ccgcctccac gtcggtcctc gatgccggtc tcgcaggcgc
    16321 ggcggacgac tccgggggcg agggccgcac ccctccgcgg tgacgggggt gccgttcccg
    16381 gctccgcggc ggggcacggg caggcctgcg gcgatcggct ccggcgtccg ccaccgcccg
    16441 gaggcaccga ccgtcccggc ctccgtccgc gctgcgcccc cgccccgctc cgcttactct
    16501 ctgtcgtgga gtcgccacag agggcgccgg gagcaggagg agccatgccg gagctgttca
    16561 tcggcggccg gtggaccgcc gccgccgacg ggggaacgcg ggagatccgc tgtccggccg
    16621 acggcacgcc ggtcgccacc gtcgacgagg gcgggcccga ggacgcccgg gcggccgtcg
    16681 ccgccgcgcg gctggccttc gacgaggggc cctggccgag gacgccggcc gccgagcgcg
    16741 ggcggttgct gctgcgggtc gcggagctgc tggagcgcga caaggacacc ttcgcgcggg
    16801 cggagtcgct ggacaccggg aagcggatgg tggagagcgc ctacgacatg gacgacatcg
    16861 ccgactgctt ccggtacttc ggcaacctcg tctccgccgg gtccaccgac cgggtcgtcg
    16921 acaccgggac ggcggacgtg gacagccgga tcgtgtacga gcccgtcggc gtctgctccc
    16981 tcatcacccc gtggaactac ccgctcctcc agaccgcctg gaaggtcgcc ccggcgctcg
    17041 cggccggcaa cacgttcgtg ctcaagccga gcgagctgac cccgcacacc gccgtcctgc
    17101 tcatggggct cctcgtcgag gccgagctgc cggagggggt cgccaacctg gtgctcggga
    17161 cgggggcggc cgtgggagcg ccgctcaccg aggacccgcg ggtggacatg gtgtcgttca
    17221 ccggcgggct ggccacgggt cgggccgtca tggcggccgc cgggccgacg gtgaagaagg
    17281 tggccctgga actgggcggc aagaacccca acatcgtctt cgccgacgcc gacttcgaca
    17341 ccgccgtcga ctacgccctg atggcggtct tcctgcacgc ggggcaggtg tgttccgccg
    17401 gggcgcggct cctggtgcag gacgagctgc acgaccggtt cgtggacgag ctggtggcgc
    17461 gggcgggccg gatccggctc ggcgggccct tcgacgagga cgcccgcggc ggcccgctga
    17521 tctccgccgc ccaccgcgac aaggtcgagg cgtacgtggc cgagggcatc gccgagggcg
    17581 ccgtactgcg gtgcgggggc gcgcggcccg acgatccggc gctggcggac ggcttctact
    17641 acccgccgac cgtgctggac gagtgccgct cggccatgtc cgtggtgcgg gacgagtcct
    17701 tcgggcccgt cctcacggtg gagcggttcc gggacgagga cgaggcggtg cggctggcca
    17761 acggcacggt gtacggactg gcgggcgcgg tctggacacg ggacgccgga cgcgcccacc
    17821 gggtggccgc tcggctgcgc gccgggaccg tgtggatcaa cgacttccac ccctacgtac
    17881 cgcaggcgga gtggggcggt atgaagcagt ccggtttcgg gcgggagctg gggccgacgg
    17941 ggctcgcgga gtaccaggag gccaagcaca tctggcgcaa cgtggccacc gtcccgcagc
    18001 ggtggttcga gtgagccgta ccgaggggtc cggtggcgcc gaagggcccg gcggccctcg
    18061 cggccgtacg gtcgacagca gccgtgacga cgccgcgctc ggggagctgg gctaccggcc
    18121 cgagctcaag cgcacgctcg gcaacttcca caccttcgcc gccgggatca gctacatctc
    18181 gatcctgacc ggcaccttcc agctcttcta cttcggcgtc accttcggcg gccccgccta
    18241 ctggtggtcc tggccgatgg tcttctgcgg gcagctgatg gtggccctgt gcttctgcga
    18301 gctggcggcc cgctatccgg tggccggttc ggtctacaac tgggccaaga agatgggcgg
    18361 cccgcacgtg gggtggctcg gcggctggat gatgatgacg gccaccatgg tcaccctgtc
    18421 ggcggtggcg ctggcctacc agatcacgct gccgcagatc gacgggtggt tccagttcgt
    18481 cggggacggc agcgggcaga acgaccaggc ggccaacgcc gtcctgctcg gcacggtgct
    18541 catcctcttc tccaccctgg tgaacgcgtt cggcgtcaag ctgatggccc ggatcaactc
    18601 cgcgggcgtc ttcatcgagc tgatcgccgc cgtcgccctg atcgtcttcc tcgccgccca
    18661 catcacccgg gggcccagca ccgccctgac ggagacgtac gggctgggcg gcggcaccgg
    18721 cctcggctac ctgggcgcgt tcctcaccgc ctcgctggcc tcggcgtacg tcatgtacgg
    18781 cttcgacacc gcctcctccc tcggtgagga gtcgcacgac ccgggccgca acgcgccccg
    18841 cgccatcctg cgggcgctca tcgcctcgtt cctgatcggc gcgttcatcc tgctcttcgc
    18901 gctgctctcg gtgccggacc tgaaggcgga ggagctgtcg acgggcggac tgcagtacgt
    18961 ggtgctggcg acgctcgggg agaccgtcgg ggagatcttc ctctgggcgg tggtcgtcgc
    19021 gatcaccgtc tgcgtcctcg ccgtgcaggc ggccggtatc cggctgatgt tcgccatggc
    19081 ccgggacaac aacctgcccg ccggatcgaa gctggcccgg gtcagccccc ggttccggac
    19141 gccggtggtg cccgccgtgg tgatcggggt ggtcggcgtg gtgatcctgg tggtcaacat
    19201 caaccagccg cagatcttct cggtgatcac cagcatcgcg atcatcatga tctacgtggc
    19261 ctatctgatg gtcaccgtgc ccatgctgct gcgccggctg cgcggcacct ggcagccgcg
    19321 cgagggcgcg ttctcgctgg gccgctgggg gctgccggtc aacgtgctcg cggtgctctg
    19381 gggcacggcg atggccctca acctggcctg gccgcgcgcc gaggtctaca acgccacggg
    19441 gccgcagcac tggtatctgc ggtggggcgc gttcctgttc atcggggtcg tcgcgctggg
    19501 cggcttcgcc tactactggt tcgtccagcg ccaccgtacg ggcgtgctcg ccgagcaccg
    19561 gtcccagccg gcggaccccg ccgttccgcc gtcccgcccc tgagcccccg ctcccccggc
    19621 ccggccccct cgaccggccc ctgaaccctt cccccctgga tccctggaga cgcgatgccc
    19681 gaggagagtc ccgtgaccgc ctacgactac gtcgtggtcg gcggcggtac ggcgggtgcc
    19741 gtcgtcgccg cccggctcag cgaggacccg gacaccaccg tctgcgtcct ggaggccggg
    19801 ccctcggacg tcggggacga cagcgtgctg cggctggacc gctggatggc gctgctggag
    19861 tccggctacg actgggacta tccggtggag ccgcaggagt acggcaacag cttcatgcgc
    19921 cacgcccgcg ccaaggtgct cggcggctgc tcctcgcaca actcgtgcat cgccttctgg
    19981 gccccggccg aggatctcga cgagtggggc gccctggggt gcacggggtg gagcgcggcg
    20041 gagtgcttcc cgctctaccg gcggctggag accaacgacg cgcccggcga ccaccacggc
    20101 cgctccggcc cggtcaccat ccgcacggtc ccgcccgccg acccgtgcgg ccgggccctg
    20161 ctggaggcgt gcgccgagtc cggcatcccc accacgccgt tcaacacggg ctccacggtg
    20221 gtcaggggcg cgcactggtt ccagatcaac gcccgcgagg acggcacccg ggcctccgcc
    20281 tcggtctcgt atctgcatcc cgtcctgggg aagcggccca acctggaggt gcggacgggg
    20341 ctccaggcga agcggctgct cttcgagggg gaacgctgcg ccggagtgga gtacctggaa
    20401 cccgacaccg tccacagcgg ccgggtgcgc gcccggcgcg aggtggtcgt ggcctgtggg
    20461 gcgatcgact cccccaagct gctgatgctc tccgggatcg gcccggccga gcacctgcgg
    20521 gagagcgggg tggaggtccg ggtggactcc cccggcgtcg gctcgcacct ccaggaccac
    20581 ccggaaggcg tgatcatgtg ggaggcgaag cggccgatgg tcaccgcctc cacccagtgg
    20641 tgggagatcg gcgtcttcgc tgacacggaa ccggggctgg accggccgga cctgatgttc
    20701 cactacggct cggtgccgtt cgacctcaac acctaccggc gcggctaccc cacctcggag
    20761 aacgccttct gcctcacccc gaacgtcacc cgcgcccgct cccggggcac ggtccgcctc
    20821 cgcagccggg acttccggga caagccgcgg gtcgatccgc gctacttcac cgacgagcac
    20881 gacgtacggg tgatgacgta cgggctccgg ctggcgcggg agatcgtcgc gcggcccgcg
    20941 atggccgact gggcggggac cgagctggcc ccggggccag gcgccaccac ggacgcggag
    21001 ctgttcgcgt acatccgcga gacccacaac accgtctacc acccggcggg gacagtccgg
    21061 atgggtccgg ccgacgaccc ggactcgccg ctcgacccgc agctgcgggt caaaggggtc
    21121 accggactgc gggtggcgga cgcgtcggtg atgccggtgc tgaccacggc caacccctgc
    21181 atcaccacca tgatgatcgg cgagaagtgc gccgatctga tcagggggaa gtgagcgcgc
    21241 gggagcgccg gtccgatgag ggagggccga ggggccggga gcatgtattc gcacatgtgt
    21301 gcgaagaagc gctacgctcg tcccatggcc cttcatctgc agacctcgct cttcgaccag
    21361 acggacgagg tcgccgtccg ccccctcgac ggggtgcgcc gcgagcagct gggcgacggc
    21421 gcctggatcg acgtgttccc gcagtggctc cagggggccg atgccctgtt cgaggcgctg
    21481 gtccgcgatg tggcctggcg cgccgaggag cgggtcatgt acgagcgggt ggtggcggtc
    21541 ccccgcctgc tggccttctt cgggcggcgc gaccccctgc cgcaccccgc gctggagacc
    21601 gtccgcacgg cgctgggggc gcactacggg gccgagctcg gggagccgtt caccacggcc
    21661 gggctctgcc tctaccggga cgggcgggac ggggtcgcct ggcacggcga caccggcggc
    21721 cgggggtcca cggaggacac gatggtcgcg atcctctcgc tgggcgcccc ccgccatctg
    21781 gcgctgcggc cccgccgccc gggccccgtc cccgtacgcc gaccgctcgg ccacggcgac
    21841 ctgatcgtca tgggcggcag ctgccagcgc acctgggagc acgcggtccc gaagacggcg
    21901 cgggtggtgg ggccccggat cagcgtccag ttccgccccg acggggtgcg ctgaacgctc
    21961 cggcgtacgc cgggcgtcgc accgcagacg gcaggcggcg gcccgacggc gggccccgga
    22021 cccctcgatc ggccccggcg ggggcgcacc gcagttgtgc cgacccccgc cagggcggat
    22081 tctgaggacc atggaccagg ccggtgtggc gcggtgagcg cgaccagagc ggcggacgcc
    22141 gccgacttcc gcggccccct ggacatcagc agggcggcca cggtggtcct ggacggccgg
    22201 gacacggtcg tcgggtggag tccggccgcc accgcgctgc tgggctacag cccgcgggag
    22261 gccgccggac ggccgctgag cgcgttcctc gggcccccgc cggccgaggg cgcgctcccg
    22321 gccggcgggg gcgcgctccc ggccgccgcc gaccgcccgt ccgcggcggg cgcaccggcc
    22381 ccctcgggct ccccggcgcg cccggggccc ggtccgccgc ccaccggcca tgagatccgc
    22441 ctcgcccgtc accgggacgg ccatgagctg ctggtggtga cggccctgtg cccgctggcc
    22501 ggcgcggggg acggcggggc gccgggacgg gtgctcgtcg ctgccgagct gggcgggctg
    22561 cggcagtggg agtcccggct cgcgctgctc caggggctcg ccacccagtc gcccgtcggg
    22621 ctggcgatct acgacaccga cctccggctg acctggagca acaccgccta cgagcgggag
    22681 atcggcaagc cgctcgcgga gtacctgggg aagcgggccg acgagctgta ctccgggggc
    22741 cgcttcgtga ccccggggta tcccccgacg ctcgacgccg tgatgcatca cgtgatcgac
    22801 accggtgaac ccgtcctcga cctgcacttc caggggattc cgccgagcga cccgggcacc
    22861 gagcacctgt ggtcgtgctc ctactaccgg ctggaggacg cccagggcca tgtcttcggg
    22921 gtctgcgagg actccttcga catctccgac cggcagcggg cccagcggcg tctggccctg
    22981 ctggtggagg tcggccgccg gatcgggacc gtcctggacg tggtcaccac ggccgaggag
    23041 atcgccgagg tgaccgtgcc ggagttcgcc gccgccgtac gggtcgacat cgcgcgggtg
    23101 acggtgatga gcggggagct gcccgccacc ggggggtctg cggcgatgga cctcctgcgc
    23161 gtgggtgagc actccgtgga cccggcggcg gccgacgcgg cagaaccgct gcgtccgggg
    23221 gcgccggggg atccggccga ccgctacccc ccggtcgcct atccgccggg ttctccgcag
    23281 gaccgcagtc tggcctcggg cggtctggtg ctcgacgaca acgtcctggt cgtgccgttg
    23341 cgcgtcggcg gcagcgtgct ggggctcgtc accttcgtcc ggagtccgcg cccccgggtg
    23401 tccggccgtc cgctcgccca cggccccgcc accaccttcg acaacggcga ggtggccctg
    23461 gccgacgagc tggccggccg ggcggcggtc tgcatcgaca acgcccgccg cttcacccgg
    23521 gagcgctccg cctcgctcgc cctccagcgc cagttgctgc cccaccacgt gccgccgcag
    23581 tcggcggtcg acatcgccca ccgctatctg ccctcggacg acgtgacggg ggtgggcggg
    23641 gactggttcg acgtgatccc gctctccggc acccgggtcg gcctggtggt cggggacgtg
    23701 gtcggccacg gtctccaggc ggccgccacc atggggcggc tgcgtacgag cgtgcgggcc
    23761 ttcgcccagc tggacatggc cccggacgag ctgctgaccc ggctggacga cctggtgggg
    23821 cagccgggcg tgccccaggg cccgccctcg gacgcgtacg acgaactgac cacgggggcg
    23881 acctgcctgt acgcggtcta cgacccggtc tcgcggcggt gcgtcatggc gcgggccggg
    23941 catctgccgc ccgcggtggt gcacccggac gggcgggtga ccttcccgga cctgccggcc
    24001 gggccgccgc tggggctcgg ggggctgccc ttcgagtccc tggagatcga gctgccggtg
    24061 gggagcctgc tggcgctgtt cacggacggg ctggtggagg cccgggacca tgacatcgac
    24121 caggggctcg ccgcgctggg ccgggtgctc ggcaccccgg ccgcgtcgct ggacgagctg
    24181 tgcgaccggg ccgtctccgc gctggtgccg gacgccacga ccgccgacga caccgccctc
    24241 ctgctggccc ggacccggca gctggacggg agccgggtcg ccgagtggga gctgcccgcc
    24301 gaggcggtgg cggtgggccg ggcgcgcgaa ctggccaccg ggcggctcgc cgcgtggggg
    24361 ctggaggagc tgtcgttcgc caccgagctg gtcgtcagcg agctggtgac caacgcggtg
    24421 cggtacggcg gcgggccgct gcggctgcgg ctcatccggg accgcacgct gctctgcgag
    24481 gtcgcggaca ccggccacac ctcgccgcat ctgcggcaca gcgcggagga cgacgagggc
    24541 gggcgcgggc tgttcatcgt cgcccagctc gtccagcggt ggggcacgcg ctacaccccg
    24601 gccggaaaga ccatctggac ggaacaggcc ttccctccag ccgagttcgg ctgattccgg
    24661 ccactttccc cggccctgac ggaccccttt gttgacaaca tcaacttctt tcgacttagg
    24721 tgtgccttgc ctaagtcgac tgggtgtccg tggttctggt tccgatgccg agaaaggtgc
    24781 tcacccgatg agtgctgtcc cctccacccg taccgtcgcc cgcacgggcc tcgccctctt
    24841 ctccgccgcc gccctggcgc tcaccctctc ctcccccgcc gccgcggcga ccgggacccg
    24901 cacgatcacc gacgggggca ccacctacaa cctgtcgctg accgccccag acacagcgaa
    24961 cgccgccgga cagaacatca ccgtcaccgg cagcggctac aacaccctgc agggcgtcta
    25021 cgtcagcctc tgcgtggtgg acggggcgca gggcgccaac aagccctccc cgtgtctcgg
    25081 cggccaggac gagtccggca ccaccggcgc ctcgcactgg gtctccaacc tcggcggcgg
    25141 cgtcctgccc aacagctcgg ccttcggcac cggcggcacc ttcagcgtcc agatccacgt
    25201 caaggccgac ctgggcggcg gcaacatctg cggcgacacc gtcgagtgcg ccgtcgtgac
    25261 ccgcgccgac cacaccgaca ccaacgaccg caagtacgac gtccacacgc cgatcgactt
    25321 cgtgtaggac accagccatc ggcccggtcc cggcgtctcc gccggggccg ggctccccgc
    25381 gttgtgacga ggaatcacat gacacccact ccgggcaccc cgccggccgg caccggccgg
    25441 cccc
//
