LOCUS       NZ_KB890945            22214 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. CcalMP-8W B053DRAFT_scaffold_4.5, whole genome
            shotgun sequence.
ACCESSION   NZ_KB890945
VERSION     NZ_KB890945.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. CcalMP-8W
  ORGANISM  Streptomyces sp. CcalMP-8W
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 514328)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   2  (bases 1 to 514328)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. CcalMP-8W
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:14:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,603
            CDSs (total)                      :: 6,529
            Genes (coding)                    :: 6,424
            CDSs (with protein)               :: 6,424
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 83 of 105
            Pseudo Genes (internal stop)      :: 5 of 105
            Pseudo Genes (multiple problems)  :: 18 of 105
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:04:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 80371
            Orig. end                         :: 102585
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB890945.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405361
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22214
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22214
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22214
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12214](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12214
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(105..114)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(396..409)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            857..1357
                     /locus_tag="B053_RS0123910"
     CDS             857..1357
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971171.1"
                     /locus_tag="B053_RS0123910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_018491111.1"
                     /transl_table=11
                     /translation="MSAREKKDLLAETDRLREGGRAGEAREKLLALTARFPDDAEVAYR
                     TAWVHDVLGLESEAVAYYERALAGTGLGAEDRRGALLGLGSTYRVLGRYGQAVETLRGG
                     AEEFPDDGALRTFLAMALFNTGEHHEAMRLLLRLVASTSDDPSVQQYRPAIEHYAKDLD
                     ETV"
     misc_feature    complement(885..899)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            1586..2233
                     /locus_tag="B053_RS0123915"
     CDS             1586..2233
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524490.1"
                     /locus_tag="B053_RS0123915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YoaK family protein"
                     /protein_id="WP_026238070.1"
                     /transl_table=11
                     /translation="MLLSAASGAADAFVFLCVGQVFAGVMTGNLVLLGASAAGAGEDGV
                     ALRVVTALTAYACGAACGALMARLPLAVVLLAEAVLLGAAAVLWGFGLVPSYGDRLGLL
                     ALVSLAMGIQGRARVTPTNYFTGTLTSLAGRAAARELGPGDGWVLGRLGAVVAGAGLAA
                     VTQRWWSPGAALGAVVLVAAALALEGVRRGGWRAAPEKGKPRPDRGNPAGAA"
     gene            complement(2457..2714)
                     /locus_tag="B053_RS0123920"
     CDS             complement(2457..2714)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019762747.1"
                     /locus_tag="B053_RS0123920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_018491113.1"
                     /transl_table=11
                     /translation="MKPRIHPVSRPVVFRDRAADVAFLTRSTADSGERVTWEDGNTYPV
                     IDVETSSASHPFYTGSRQVLDTAGRVERFRRRYGAEAPRG"
     misc_feature    2787..2802
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.81"
                     /tool="antismash"
     misc_feature    2789..2803
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(2791..2802)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            complement(2875..3492)
                     /locus_tag="B053_RS01000000134560"
     CDS             complement(2875..3492)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS01000000134560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018491114.1"
                     /transl_table=11
                     /translation="MPRPLRSADGGAVVDGWTAAEFLDGRTGPRRQWSGVLAAGRALHA
                     ALREEPRPDFLDRRTHPWAVADRVAWGERESDVVAELAEPFALLLSRWRPVEASAQLVH
                     GDLAGNVLLAPGRDPAVIDFTPYWRPPLYAEAVVIVDGLLWYDLPPGLLAAGAGDPRRH
                     QMLIRALIFRLVALSGLAGPSWSAGEKEAARFLAVAEAIERG"
     gene            3980..5452
                     /locus_tag="B053_RS0123930"
     CDS             3980..5452
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956434.1"
                     /locus_tag="B053_RS0123930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_018491115.1"
                     /transl_table=11
                     /translation="MPSPLFADRPAPQPPAPEAVDALIHRARQLRGDVAAVGRDAATGE
                     DDPQARWQRALCDLAVQHLDNLDQHLGQLRAGPPARRSGARHAPADGPPADGPPPQRVG
                     SAEWNLLTDEVSWSEELYEIFGRPPGSPPLSLDDLPSVLLPDDQAKLTAMVTGCLVDGR
                     PMDGEFRIVLPDNRVRTLHMTGEPVLDAEGCTAAMWAVLRDVGELRRGEESVDRSRDAA
                     LRDGHHDTPPREAALHDGATGHASPEHREEPAAEEPVAPPWRGSLRLPPPGDRPGTLDI
                     AAHHLPSASGGLIGGDWYDAMELPDGRTLLTVGDLTGHALPATSAMSLVLGALRGMALA
                     GIEPGALMGHLDHLLESSMRSALGSALCCRYDSAGGVLSWAQAGHPPPLLFRDGTARQL
                     PPPDGVLLGAGSQLAYEQDEVRLLPGDVLMLHTDGLTRRDDRGAGPERLLALAPRFAHA
                     RTAQECVRGVVEEFGGAERLDDACVLVARIRA"
     gene            complement(5648..7144)
                     /locus_tag="B053_RS0123935"
     CDS             complement(5648..7144)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606686.1"
                     /locus_tag="B053_RS0123935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018491116.1"
                     /transl_table=11
                     /translation="MTGEPNTRLSDLFGLAGWSKGELARMVNRQAAAMGHPQLATDTSR
                     VRRWIDMGESPRDPVPEVLAALFTERLGRVVTIEDLGFGRRGRAGKRRDSGTERDPDQL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAVLAAGSTIAGPMYDWLHSDPVLAADAPR
                     ANEPQHADPAGLDRYEAAPVGSEEIEALEYSVEVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGDETLPRTQAMLRTIEAWAHAAMGKGQA
                     MRRTLGEAEELFVSDKGDVPPPSWMQMFDEADLHGMQALAFRTLAEHDPAAAVIAQRHA
                     KQALELRVGGRQRSKLFDHISLASACFIANDPEQGDRYARLALISMGETSSHRTWDRLR
                     AMYRLTGQFAGHARIQDLREQIERSLPQSPIARKAKGAQA"
     gene            7376..8515
                     /locus_tag="B053_RS0123940"
     CDS             7376..8515
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="B053_RS0123940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_026238071.1"
                     /sec_met_domain="APH (E-value: 5e-18, bitscore: 60.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPLRPMGTGGGPYLAPHAGAPAQGLGGRTRRAA
                     GPGAGPLSGRIDLSGPQGAQVRMAIASVQRICPEFNPVQVLRRSGRSVLIVGATGRATA
                     VAKCLLDHSPAWTERFQHEIAAYRAFVRHRPPVRVPRLIAADPENCTLVIERMPGRVAA
                     LTRHPAEAPPRADIRAALGAIARVNAWRPPPGLFEAPLDYGSRITRYHELGLFTDRDLG
                     DLQKLLHGLAQAGGRQSMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLW
                     TVLGDAPAARRQISQLAQARGPAARDAFLVNLMLVLTREIRNYETAVQRTMREAPPVSA
                     GQDRPGVLSSGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    7700..7702
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9088..9831
                     /locus_tag="B053_RS0123945"
     CDS             9088..9831
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971163.1"
                     /locus_tag="B053_RS0123945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="WP_018491118.1"
                     /transl_table=11
                     /translation="MPRTIRITRSHKLAAAVLVAAGSVTAITATGGQSEAQPTAATSSA
                     TAGKAATGAPTAQEIAAEKAAAESAAKKAAAGAAAAKKVAADREAAAAKAVAERRAEAK
                     KAAEKARSEKQAANRSTERKAVAAPKKAAPKAAPKKYADNLDGWIRESLDIMKKKNIPG
                     SYEGLHRNIMRESSGNPHAVNDWDINARNGIPSKGLLQVIQPTFDAYHVKGTPKKLTDP
                     VANITAAANYAADRYGSIDNVDSAY"
     misc_feature    complement(9885..9899)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 20.1"
                     /tool="antismash"
     gene            10001..12214
                     /locus_tag="B053_RS0123950"
     CDS             10001..12214
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515109.1"
                     /locus_tag="B053_RS0123950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_026238072.1"
                     /sec_met_domain="T1TS (E-value: 1.7e-84, bitscore: 279.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFSLPDFYVPYPARLNPHVEAARTHTREWARGMGMLEGSGIW
                     DEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDREGAKRY
                     LDRLPAFMPMERGAAVPEPENPVEAGLADLWERTVPSMSDAWRARFAVATENLLNESLW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSAGLVEYAADAEVPAAVAGSRPLRVLRDAFS
                     DGVHLRNDLFSYQREVEDEGENSNGVLVLEKFLGCTTQEAAEAVNDLLTSRLHQFENTA
                     LTELGPLCAEKGLDPAQTASVLAYVKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVAGFG
                     MSAASIRFTLRSETARARSHSHRPFQHVGPSIVPDLKLPFSTTLSPHLEGARLRLVDWA
                     RRMGILEAQPGVPGSHIWDEERILAIDLPLCAAGIHPDASPEELDISSAWLAWGTYGDD
                     WFPVVHGRTRDLAGARLANERLSLFMPLDGEAAPEPVNALERSLGDLWLRTAEPMDLDA
                     RRAFRTAIESMTESWLWELANQAQNRIPDPVDYTEMRRATFGSDLTMSLCRLAHGRKVP
                     AAVYRSGPMRSLENAAADYACLLNDLFSYQKEIEYEGEVHNGVLVVQNFFGVDYPTGVR
                     IVHDLMESRLRQFLHVAEVELPVLYDDFALDAEAREVLAGYVQELKHWLAGILIWHRGC
                     RRYREEDLRRGHGAPQILAGPTGLGTSAAQVTRLMAELAGSRA"
     gene            complement(12428..12928)
                     /locus_tag="B053_RS0123955"
     CDS             complement(12428..12928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="B053_RS0123955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_003971159.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLYGGRGPAMIIGNLPEGSPARETEEGQVPFEVAQLLLALENDEPIEVVSSEDV
                     PVMQGDNLLIVRRVKLSESRIACVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELF
                     QQG"
     gene            13243..14808
                     /locus_tag="B053_RS0123960"
     CDS             13243..14808
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515107.1"
                     /locus_tag="B053_RS0123960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_018491120.1"
                     /transl_table=11
                     /translation="MTVEGTVGGLEERVAGRAWMVRLDPADRGGTAVRVSCGRPGCAPQ
                     VLPSAAVGRTAAVAHLATHLRAASGPRPEAYCACRADDCHTHVRTDGPRDRAPASRCGG
                     PVVLAVINDRQGRWWRALECCARCAAAHPSAKVVATAPAVAAPSAALAPAGAARAAAPR
                     PPAQIGPQFSHAASAPAPVPEGVPAARPPRPRRKRRSGKIAQRIVPFDLHPVALREELI
                     ELGDLFRAYQQRPEPDLVELSELHSRKAKAFRTWAEVTGETELRLEAERAEQAAAAALL
                     QHQQRTGQSPAGDGQVTSRLLPGLTQWDHARAILAHVAGHTPVPGAEARLLAVLLTLRS
                     ALTGIGNLVGQDVRGLPLTDPEELIGRLVESGWLSFPGTVEELLASRPEDPTPVTIPSL
                     MPDEDGPGPFVFGRKTRPKLSGWAQRVVGDKKLRKKRTGADVRLLALALAVRTSADGRL
                     GPDGEGVEVEPLASWCCVGPEGLEPLVEQLTVADWLTDAEFTADGLLRGRLTERVLPVS
                     CPLA"
     gene            complement(14860..16026)
                     /locus_tag="B053_RS0123965"
     CDS             complement(14860..16026)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="B053_RS0123965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_018491121.1"
                     /transl_table=11
                     /translation="MTKEPVAVVGIGQTKHVAARHDVSIAGLVREAAVRALEDAALTWN
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDTVGS
                     LVAYKDRRNALKNPYAHIHDPDLTLEKVQASPMLWDPIRYSETCPSSDGACAMVLTDRD
                     GASRAPHRPAWVHGGAMRSEPTLFAGKDFVSPRAGRDCAADVYRQAGITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFAAEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGRAGDHQIDGATRAVGHAYGGGAQFFAMWLVGSRPPPG"
     gene            complement(16019..17071)
                     /locus_tag="B053_RS0123970"
     CDS             complement(16019..17071)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060725.1"
                     /locus_tag="B053_RS0123970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_018491122.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQSPHRRRTDELSEVDLLMPVLHQVLETTGLRANEI
                     GFTCSGSADYLAGRAFSFTMALDGVGAHPPISESHVEMDGAWALYEAWVKIMTGEADTA
                     LVYAYGKSSPGQVRDVLTRQLDPYYLAPLWPDSVSLAALQAQALLDAGRTDRAALTAIA
                     TRSRADATANPYAQLTGDVPVGDLLVHPLRTGDCPPIGDGAAAVVLAAGDTARALCTRP
                     AWIRGIDHRIEAHGLGVRDLTDSPSTRLAARHAGAFERPVDTAELHAPFTAQEVILRRS
                     LDLGDDVRVNPSGGALAANPIMAAGLVRLGEAAARIHRGVSDRALAHATSGPCLQQNLV
                     AVLEGESAHD"
     gene            complement(17072..18019)
                     /locus_tag="B053_RS1000000137930"
     CDS             complement(17072..18019)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="B053_RS1000000137930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="OB-fold nucleic acid binding domain-containing
                     protein"
                     /protein_id="WP_018491123.1"
                     /transl_table=11
                     /translation="MTEILSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTDDGRV
                     LVPPVEYDPVTANELRSLVRVAPTGTVTSWAWNPSPRRGQPLGTPFAWVLVRLDGADTA
                     LLHALDAPGPDAVRTGMRVRIRWAATRTGAITDIACLEPYDGEPETAEPAPHEGEFADP
                     VTGITVPARLDYVHTPGRAQSAYLKALEDRRTVGERCPACRKVYVPPRGACPTCGIATA
                     EQVEVGPRGTVTTFCIVNIKAKNLDIEVPYVYAHIALDGADLALHGRIAGIPYDEVRMG
                     LRVEPVWAEGTRHVDHYRPTGEPDADYDTYKELV"
     gene            complement(18090..18890)
                     /locus_tag="B053_RS0123980"
     CDS             complement(18090..18890)
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 1.8e-53. Score:
                     173.3. Matches aSDomain:
                     nrpspksdomains_B053_RS0123980_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956444.1"
                     /locus_tag="B053_RS0123980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_018491124.1"
                     /transl_table=11
                     /translation="MGGTEHLTVEREGATLVLTLNRPEARNALSLPMLVGLHDGWLAAD
                     ADDGIRSIVLTGAGGAFCSGMDLKALAGDGMAGQEYRDRMTADPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRPYTADEAAAIGLVGRVVPDGTAREEALAVAERINACGPLAVEAVKASVYE
                     GAELTESEALAAELKRGWPVFATEDAKEGARAFAEKRPPVYRRA"
     aSDomain        complement(18117..18863)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B053_RS0123980_ECH.1"
                     /evalue="1.80E-53"
                     /label="B053_RS0123980_ECH.1"
                     /locus_tag="B053_RS0123980"
                     /protein_end="258"
                     /protein_start="9"
                     /score="173.3"
                     /tool="antismash"
                     /translation="EREGATLVLTLNRPEARNALSLPMLVGLHDGWLAADADDGIRSIV
                     LTGAGGAFCSGMDLKALAGDGMAGQEYRDRMTADPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     PYTADEAAAIGLVGRVVPDGTAREEALAVAERINACGPLAVEAVKASVYEGAELTESEA
                     LAAELKRGWPVFATEDAKEGARAFAEK"
     misc_feature    18944..18959
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    complement(18949..18963)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.75"
                     /tool="antismash"
     gene            19057..20676
                     /locus_tag="B053_RS0123985"
     CDS             19057..20676
                     /NRPS_PKS="Domain: AMP-binding (8-437). E-value: 3e-64.
                     Score: 209.0. Matches aSDomain:
                     nrpspksdomains_B053_RS0123985_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060730.1"
                     /locus_tag="B053_RS0123985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_018491125.1"
                     /sec_met_domain="AMP-binding (E-value: 3.2e-68, bitscore:
                     224.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVVDVVPDREALLYVDHPGTGAERRLTYLQLDAAA
                     NRIAHHLIGAGLRPGEHLGLHLYNGIEYLQTVLGALKARLVPVNVNYRYVEEELVYLYR
                     DADLAGLVFDGEFDERVAAASTQAPALRHLIRVGSTEPPVTPGAVPFTEAEASGSPARG
                     FGPRSAEDQFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKSPQELAERVAAG
                     GDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFAPEEVLRTIEREKVTSVSLVGD
                     AMLRPLIDALKGPLRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSESG
                     FNGTATADSGPERGFRVQVNARTAVVDPVTYEPVAPGEVGRIAQRGHVPLGYYNDPAKT
                     ADTFFHKDGERWVLLGDMATVDADGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHPDV
                     YDALVAGVPDARWGSRVAAVLELREGAAALDLAAVQAHCRTRLAGYKIPRALVLADRIR
                     RSPSGKADYRWAKAVAAAGADG"
     aSDomain        19081..20367
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B053_RS0123985_AMP-binding.1"
                     /evalue="3.00E-64"
                     /label="B053_RS0123985_AMP-binding.1"
                     /locus_tag="B053_RS0123985"
                     /protein_end="437"
                     /protein_start="8"
                     /score="209.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVVDVVPDREALLYVDHPGTGAERRLTYLQLDAAANRIAHHLI
                     GAGLRPGEHLGLHLYNGIEYLQTVLGALKARLVPVNVNYRYVEEELVYLYRDADLAGLV
                     FDGEFDERVAAASTQAPALRHLIRVGSTEPPVTPGAVPFTEAEASGSPARGFGPRSAED
                     QFIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKSPQELAERVAAGGDGITFFP
                     TPPLMHGTSTLTAFIGFNFGQRVVVHRKFAPEEVLRTIEREKVTSVSLVGDAMLRPLID
                     ALKGPLRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSESGFNGTATAD
                     SGPERGFRVQVNARTAVVDPVTYEPVAPGEVGRIAQRGHVPLGYYNDPAKTADTFFHKD
                     GERWVLLGDMATVDADGIVTVLGRGSQCIN"
     CDS_motif       19573..19623
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B053_RS0123985_0001"
                     /evalue="3.00E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="B053_RS0123985"
                     /protein_end="189"
                     /protein_start="172"
                     /score="19.8"
                     /tool="antismash"
                     /translation="FIIYTGGTTGMPKGVMW"
     CDS_motif       20218..20265
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B053_RS0123985_0002"
                     /evalue="3.10E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="B053_RS0123985"
                     /protein_end="403"
                     /protein_start="387"
                     /score="13.2"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTADTF"
     misc_feature    20859..20873
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    22008..22022
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(22009..22022)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
ORIGIN
        1 agggcgcggc cggagcccgg cttggcggcg tccccgaccg ggcggccgcc cgcgcccctg
       61 gcaccggttc cggacgccgc cagtgtcttc gtcccggtgc ggtcggccgc cttcggcttc
      121 gccgtcttcg gctcccccgc cttggaaccc gccgccttgg aacccggcgt cttgggaccc
      181 ggcgtcttcg cgtcccgcgc cttgggctcc ggcgtctccg gcccggacgt cctcggctcc
      241 ggtacggccc tcgcctcctc ggccggcgag ggatgtgcgt agacgtggta gcggtggctg
      301 agccggcggc ccagcaggaa gtagccgagc agggcacccg tcgtgttgag gatgacgtcg
      361 tcgatgtcga aggcgcgtcc ggtgaccagg gcaccctgga ccagttccac gatgaccatc
      421 agggcggcgg tcagcagcgt catggtgacc atccgcagac ggcgcggcac gaggaacggc
      481 agcagcagcc cgaagggcac gcccagcagg atgtttccgc ccgcctgctt gcaggcggcg
      541 aggaaggtgt agtcctcggc gtactggcgc agggaccgcc ccggctgcag gttggaggtg
      601 acgatgtccg cggaggccgg tgacggggtg agcgtcacct tggccagcag gacggagaag
      661 gccaccagcc ccagcagcac caccgtcagg acggtcattc tcagcagtac gcgtgtccat
      721 atcccctgtc gcgcaggagt gttcttctcc gcagtcatgg cggactggtg cccccaccgg
      781 ggcggaagac acccggccgg ccgccccggc ccggaaattc gtccggccgt ccggtggcgc
      841 ctgcgacgat gggcgtatga gcgcacgcga gaagaaggac ctgctggccg agaccgaccg
      901 gctgcgcgag gggggccggg ccggggaggc gcgggagaag ctgctggccc tgacggcccg
      961 cttccccgac gacgcggagg tggcctaccg caccgcgtgg gtccacgacg tcctgggcct
     1021 ggagtccgag gcggtggcct actacgaacg cgccctggcg gggacggggc tcggtgcgga
     1081 ggaccggcgg ggagcgctgc tgggcctcgg cagtacctac cgggtactgg ggcggtacgg
     1141 gcaggccgtg gagacgctgc gcgggggcgc cgaggagttc ccggacgacg gcgcgctcag
     1201 gacgttcctg gcgatggcgc tgttcaacac gggcgagcac cacgaggcga tgcggttgct
     1261 gctgcggctg gtggcgtcga ccagcgacga cccgtctgtc cagcagtacc gtccggcgat
     1321 cgagcactac gcgaaggacc tcgacgagac ggtgtgaccg gcgcgttccg ggtggcgacg
     1381 gcgcggggcg ccggaggggc gcggcggggg caggggtccg cggcgcgccg cgtccgccgt
     1441 ggagtgcggc cccgggcccg tagatatcga gaatgctccc gtgcactccc cttccccgcc
     1501 cgcgtccccc tcgtcccctt cacccggctc ccccgccgcc gcgccccgga ccggcgctct
     1561 ctcccggcgc ggtgagtcgg ttctgctgct tctctccgcg gcttccggcg cggcggacgc
     1621 gttcgtcttc ctctgtgtgg gccaggtctt cgcgggcgtg atgaccggga atctggtgct
     1681 gctgggggcc tcggcggccg gggcgggcga ggacggtgtg gcgttgcggg tggtcacggc
     1741 gttgacggcg tacgcctgcg gggccgcgtg cggtgcgctg atggcccggc tccccctggc
     1801 cgtggtgctg ctcgccgagg ccgtcctgct cggggcggcg gccgtgctct gggggttcgg
     1861 cctggtcccg tcgtacggag accggctcgg gctgctggcg ctcgtctcgc tggcgatggg
     1921 gatccagggg cgcgcccggg tgacgccgac gaactacttc accgggaccc tcacctccct
     1981 ggccggccga gcggcggcgc gggagctggg gccgggcgac ggatgggtgc tgggccggct
     2041 gggcgcggtg gtggccgggg cggggctcgc cgcggtgacg cagcggtggt ggagtcccgg
     2101 ggccgcgctg ggcgcggtgg ttctggtggc cgcggcgctg gccctcgaag gcgtgcggcg
     2161 cggagggtgg cgggcagcac cggagaaggg gaagccccgg ccggatcggg ggaatccagc
     2221 cggggcggct tgagggtggg tgtgacgcgc ggccgcctcg cggcggaggg ctccgacggg
     2281 tgtcggcctc gcggctctcc ccagggctgt cggtgcggcc cgggggcgcc ggccgctcgc
     2341 tcccacgtat aggtgaacga taaaccatct cgggttgttc ccgggaaccg ggcccccgcc
     2401 cctgtgaccc atgacacgga acccccggtt ccgccgatgg tccggggtgc ggcgggtcag
     2461 ccgcgcggcg cctcggcgcc gtaacggcgg cggaaccgct ccacgcggcc ggccgtgtcg
     2521 agcacctgtc ggctcccggt gtagaacggg tggctcgccg acgaggtctc cacgtcgatg
     2581 acggggtagg tgttgccgtc ctcccaggtc acacgctcgc cggagtcggc ggtggagcgg
     2641 gtgagaaagg cgacgtccgc tgcgcggtcc cggaagacca cggggcggga gacggggtgg
     2701 atacggggct tcatcgatgc gttccttcct cgctgcgggg cgggcggccg aggcccggag
     2761 gagcctggcg ccaccgccgt aacggtgatg ggattcgttt tcgttctgct gggagaacac
     2821 acctcgcccc gtcggcattc ccgggccgga ccggtcggca tctcccgggc cggatcagcc
     2881 gcgctcgatg gcctccgcca ccgcaaggaa gcgggcggcc tccttctccc cggcgctcca
     2941 ggacggtccg gcgagcccgc tcagcgcgac gagccggaag atcagcgccc ggatcagcat
     3001 ctggtgccgg cgggggtcgc ccgcaccggc ggccaggagg cccggcggca ggtcgtacca
     3061 gagcaggccg tccacgatca ccacggcctc ggcgtagagg ggcgggcgcc agtagggggt
     3121 gaagtcgatg acggcggggt cccggccggg cgcgaggagc acattcccgg ccagatcgcc
     3181 gtggaccagc tgcgccgacg cctcgacggg ccgccaccgg gagagcagca gcgcgaacgg
     3241 ctcggccagt tccgcgacca cgtcggactc ccgctcaccc caggcgaccc ggtcggccac
     3301 cgcccagggg tgcgtccggc ggtccaggaa gtcggggcgg ggctcctccc gcagggcggc
     3361 atggagagcg cggcccgccg ccagcacccc cgaccactgc cgccgggggc cggtacgccc
     3421 gtccaggaac tcggcggcgg tccacccgtc gaccacggcg cccccgtcgg ccgaccgcag
     3481 gggccggggc acccggaacc cggcaccccg gggagccgct ccatcacgga cgcggcccac
     3541 tccgactcct ccaccgcccc ctcggcgggc ttcaggacgg ccccgccgac gcgcacgctg
     3601 cgaccctggc cacccgccag gggctcgggg acgccccgca ggccgaaggc gtcgagaacg
     3661 cgctgcgggg gcaggggaac acgcggcggt ccaggcatgc gggccatcct cccgggccgc
     3721 gccaccgccc gcacgcgcat tccggcccgt cccctcgacc ggaccccgcc ggccgacgcc
     3781 tgtgccacag ggacaggtca acacccttta cccgtaagct cgttcggacc gccgccgacc
     3841 acgtacagcc gctgacatat gccagaagca actacgtgac gagtgttgtc gaatgcctta
     3901 cgggccgccg cgggctgtgc gaaagtcgat agcggccgcc ctgagacccg gccgcgccgc
     3961 gcctgtatcg gagtacgaga tgccgtcccc tctgttcgcg gaccgccccg caccgcagcc
     4021 ccccgcgccc gaagccgtcg acgcgctgat ccaccgcgcc cggcagctgc gcggggacgt
     4081 ggcggccgtg ggacgggacg cggcgaccgg agaggacgac ccccaggccc gctggcagcg
     4141 tgccctgtgc gacctggccg tccagcatct cgacaacctc gaccagcatc tgggccagct
     4201 cagggccggt ccccccgccc ggcgttccgg cgcacggcac gctcccgcgg acggaccgcc
     4261 ggccgacggt cccccgccgc agcgggtggg cagcgccgaa tggaacctcc tcaccgacga
     4321 ggtcagctgg tccgaggagc tgtacgagat cttcggccgg ccgcccggtt caccgccgct
     4381 ctccctggac gacctgccgt ccgtcctcct ccccgacgac caggcgaagc tcaccgccat
     4441 ggtgacgggc tgtctcgtcg acggacggcc gatggacggg gagttccgca tcgtgctccc
     4501 cgacaaccgg gtgcgcaccc tccacatgac cggcgaaccg gtgctcgacg ccgagggctg
     4561 caccgctgcc atgtgggccg tgctccggga cgtcggggag ctgcgccgcg gcgaggagag
     4621 cgtcgaccgg agccgggacg cggccctgcg cgacgggcac cacgacacgc ccccgcgcga
     4681 agcggcgctg cacgacgggg ccaccggaca cgcctccccc gagcacaggg aggagcctgc
     4741 ggccgaggag cccgtggcgc cgccgtggcg cggttccctg cgcctccctc ctcccggaga
     4801 ccgccccggc accctggaca tcgccgcgca tcacctccct tccgcatccg gcggcctcat
     4861 cggcggcgac tggtacgacg cgatggagct gcccgacggc cggaccctgc tgaccgtcgg
     4921 cgatctgacc gggcacgcgc ttcccgccac ctcggccatg tccctggtcc tcggcgcgct
     4981 gcgcggcatg gccctcgccg gtatcgagcc gggtgccctg atgggtcacc tcgaccacct
     5041 cctcgaatcg tcgatgcggt ccgccctggg cagcgccctg tgctgccggt acgactccgc
     5101 gggcggggtg ctctcctggg cgcaggccgg tcacccgccg cccctgctct tccgtgacgg
     5161 gacggctcgg cagctgccgc ccccggacgg ggtcctcctc ggtgccgggt cccagctcgc
     5221 gtacgaacag gacgaagtgc ggctgctccc cggcgatgtg ctgatgctgc acacggacgg
     5281 cctgacccgc cgcgacgacc ggggtgcggg cccggagcgg ctgctcgccc tcgccccccg
     5341 gttcgcacac gcccgtacgg cgcaggagtg cgtgcggggc gtggtcgagg agttcggcgg
     5401 ggccgagcgc ctggacgacg cgtgtgtgct ggtcgcccgt atcagggcat gacggggccg
     5461 aggtccggcc ctcggggctg ccgtaccgcc tgacggagga ccgccgggtg ccatggcggg
     5521 agaccgtcgg gacctctgca cgccaggtcg tgggtacacc aggtcatgga tacgccgagg
     5581 cctcggatcg tcggggcgtg gggtgcgcgc ggcggttacg gtctccgccg gcggacccgt
     5641 acggagttca cgcctgggcc cccttggcct tcctcgcgat cgggctctgc ggcaacgacc
     5701 gctcgatctg ctcgcggagg tcctggatcc tggcgtgccc ggcgaactgg ccggtgagcc
     5761 ggtacatcgc acggagccgg tcccaggtgc ggtgggacga ggtctccccc atggagatca
     5821 gggcgagcct cgcgtaccgg tcgccctgct cggggtcgtt ggcgatgaag caggccgagg
     5881 cgagcgagat gtggtcgaag agcttggagc gctggcgtcc gcccacccgc agctccaggg
     5941 cctgcttggc gtggcgctgg gcgatgacgg cggcggccgg gtcgtgctcg gccagcgtgc
     6001 ggaacgccag ggcctgcatg ccgtgcaggt ccgcctcgtc gaacatctgc atccagctgg
     6061 gcgggggcac gtcgcccttg tccgagacga acagttcctc ggcctcaccg agggtgcgcc
     6121 gcatggcctg gcccttgccc atcgccgcgt gggcccaggc ctcgatggtg cgcagcatcg
     6181 cctgcgtacg gggcagggtc tcgtcgcccg agccggactt ggcgagcttc atcaggtcga
     6241 gggcgtcgtc gggacggccc aggtggacca tctggcgggc ggcgcgggag agcgcctcac
     6301 cggcgcgcgg ccggtcgccg ccctcacggg ccgcgtgggc cgcgatgacg aagtacttct
     6361 gggcggtggg ttcgaggccg acgtcgtggg acatccagcc cgcgaggacg gcgaggttgg
     6421 cggcgacgcc ccacaggcgg cgctggaggt ggtcggggtg gcggtaggcg agcatgccgc
     6481 ccacctcgtt gagctggccc accacggcct tgcgctggag cccgccgccc cgggaggcgt
     6541 cccaggcccg gaacacctcg accgagtact cgagggcctc gatctcctcg gagcccacgg
     6601 gcgccgcctc gtaccggtcg agaccggcgg ggtcggcgtg ctgcggttcg ttggcgcgtg
     6661 gcgcgtcggc agccaggacg gggtcgctgt gcagccagtc gtacatgggg ccggcgatgg
     6721 tcgagccggc ggcgagcacg gcgcccgcac ccaccaagcc gcgtcgattg agcatgaggt
     6781 ccattcccgt gaattcggtg aggaccgctg ccgtccgctc gggcgcccac ggcagttgat
     6841 cgggatcgcg ttccgtcccg gagtcacgcc gtttccctgc acgcccgcgt cggccgaacc
     6901 cgaggtcctc gatggtcacg acacggccga gccgctcggt gaacagggct gccagcactt
     6961 ccggcacggg atcacggggg gactccccca tgtcgatcca gcgcctgacc cgcgaggtgt
     7021 cggtggccag ctgcggatgg cccatggccg ccgcctgccg gttcaccatt ctcgcgagtt
     7081 cgcccttgga ccagccggcc aggccgaaca ggtcggaaag acgggtgttg ggttctccgg
     7141 tcacgtcaag cccccaggtt ctcggctgac ttgacactaa ccccctgtca gatgcgccgt
     7201 gactattcgc cagggttcgc cagggtccgc cagatggtct gccacccgcg ctccggtgtc
     7261 aggtaggaaa gcgccacccc gcccggcagc cctaggtact ccccagggtg ccgaacggcc
     7321 gtcggccggg ttggcgtacg taacttgtcg gcgcacgaag ggatctgtct cgcccatgta
     7381 cacagcatcg tcctccgtgt ccgccccgcc ccggccgctc cgtcccatgg ggacgggcgg
     7441 cgggccgtat ctcgcccccc acgccggtgc gccggcacag ggcctgggcg gccggacccg
     7501 gcgggcggcg ggaccgggtg ccggacctct cagcggcagg atcgacctct ccgggccgca
     7561 gggcgcacaa gtgcggatgg ccatcgcctc cgtgcagcgc atctgccccg agttcaaccc
     7621 cgtccaggtg ctgcggcgca gcggccgttc cgtgctgatc gtgggcgcca ccgggcgggc
     7681 caccgccgtg gccaagtgtt tactggacca ctcccccgcc tggacggaac ggttccagca
     7741 cgagatagcg gcatatcgcg cgttcgtccg gcaccgcccc ccggtgcggg tgccccggct
     7801 gatcgcggcg gatccggaga actgcacgct ggtgatcgag cgcatgcccg gacgggtggc
     7861 cgcgctgacc cggcatccgg cggaggcccc gccgcgggcc gacatccggg ccgcgctcgg
     7921 ggcgatcgcc cgggtgaacg cctggcggcc gccgcccgga ctgttcgagg cgccgctcga
     7981 ctacggttcg cggatcaccc gctaccacga gctcggtctc ttcaccgacc gggatctggg
     8041 cgacctccag aagctgctgc acggtctggc ccaggcgggc ggccgtcagt ccatgggcca
     8101 gttctgccac ggtgacgcgc tgctctccaa catcctgctg tcgccgaccg gcccggtgct
     8161 ggtcgactgg gagcacgcgg gctggtacct gccgggctac gacctggcga cgctgtggac
     8221 ggtgctgggc gacgccccgg cggcgcggcg ccagatcagc cagctggcgc aggccagggg
     8281 cccggccgcg cgggacgcgt tcctggtcaa cctgatgctc gtgctgaccc gcgagatccg
     8341 caactacgag acggccgtcc agcgcaccat gcgcgaggcg cccccggtga gcgcggggca
     8401 ggaccggccg ggggtgctct cctcgggcga ggagcagcgg ctgctgctgc gccggctgca
     8461 cgacgactgc gcgatggcgc ggcgggcggt gcgggcggcg gtcgggaccc gctgagtccg
     8521 gacggccaga aggccactgt gtaagggaag cgcgctgcgg gaccggtgcc gacacaccgg
     8581 tcccgcagcg cgttgtgctg tgtccggacg ggggcgggga cggggacgta cggacatagg
     8641 gcacacgggc acacgggcac acgggcacac gggcacacgg gcacggacac acgggcacgg
     8701 catggcggga gagggctccg gggcggcggc gaagtccgca agaagcggtg ccgctccgtg
     8761 acgggacatg gaccgaccgc cacccgaggg gctcccccgg gtgaggcgcg ccacgagacc
     8821 cacgtcacct acgagccgga gtagtgggtg cgaccgctcc cctgcggtgc ggagaaaacg
     8881 ccaaaaggga tattccgctc catcgactac tcaccctagt aaatagggtc attgcctcct
     8941 gtctcgacgg ccgttaacca tggatcccgg cagacaccga gaccgatccc gcgacgagcg
     9001 ccccacggcg gtcgcggccg gcatctcccg gtctccgccc acgcggccca tggccgcagg
     9061 ccccgtcccc cacaggaaga gttccgcatg ccccgcacca tccgcatcac ccgctcccac
     9121 aagctcgccg ccgccgtgct cgtcgcggcc ggttccgtca cggccatcac cgcgaccggc
     9181 gggcagagcg aggcgcagcc caccgccgcc acgtcctccg ccaccgccgg gaaggccgcc
     9241 accggcgccc cgacggccca ggagatcgcg gcggagaagg ctgcggcgga gagcgccgcg
     9301 aagaaggcgg ccgccggcgc cgccgcggcg aagaaggtcg cggccgaccg cgaggccgcc
     9361 gccgcgaagg ccgtcgccga gcgcagggcc gaggcgaaga aggcagccga gaaggcccgc
     9421 tccgagaagc aggccgccaa ccgttccacc gagcgcaagg ccgtggccgc accgaagaag
     9481 gccgccccca aggccgctcc caagaagtac gcggacaacc tcgacggctg gatacgcgag
     9541 tcgctcgaca tcatgaagaa gaagaacatc cccggctcct acgaggggct gcaccgcaac
     9601 atcatgcgcg agtccagcgg caacccgcac gccgtcaacg actgggacat caacgcccgc
     9661 aacggcatcc cctccaaggg cctgctccag gtgatccagc cgaccttcga cgcgtaccac
     9721 gtcaagggca ccccgaagaa gctcaccgac ccggtcgcca acatcaccgc cgccgccaac
     9781 tacgccgcgg accggtacgg ctcgatcgac aacgtcgact ccgcctactg agccgacacc
     9841 gcacatcgca ggccgccgca ccgaagaggc acagaccaga ccgcgattat ctgactaatc
     9901 cccctggtgc gtgccccggt tggccgaagg gtagggctgg cgcggacacc atcgatccgc
     9961 gccctcgccg cgcggagcct tccggaaagg cctatcgcac atggcacagc ccttctcact
    10021 gccggacttc tatgttccgt atccggcccg gctcaaccct catgtggagg cggcacggac
    10081 gcatacccgg gagtgggcac gcgggatggg gatgctggag ggatccggca tctgggacga
    10141 gaaggacctc gaggcgcacg actacgccct gctctgcgcc tacacccacc ccgactgctc
    10201 ggccgaggcc ctgtccctgg tcaccgactg gtacgtgtgg gtcttcttct tcgacgacca
    10261 cttcctggag ctgttcaagc gcacgcccga ccgtgagggc gccaagcgct atctcgaccg
    10321 gctgcccgcc ttcatgccga tggagcgcgg ggcggccgtg cccgagccgg agaaccccgt
    10381 cgaggcgggc ctcgccgacc tgtgggagcg aacggtcccc tcgatgtcgg acgcgtggcg
    10441 cgcccggttc gcggtggcga cggagaacct cctcaacgag tcgctgtggg agctctccaa
    10501 catcaacgag ggccgcatcg ccaaccccgt cgagtacatc gagatgcgcc gcaaggtcgg
    10561 cggcgccccc tggtcggccg ggctcgtgga gtacgcggcc gacgccgagg tgcccgcggc
    10621 cgtggccggg tcgcgcccgc tgcgggtcct gcgggacgcc ttctccgacg gggtgcacct
    10681 gcgcaacgac ctcttctcct accagcgcga ggtcgaggac gagggcgaga acagcaacgg
    10741 ggtcctggtc ctggagaaat tcctcgggtg cacgacccag gaggccgccg aggccgtcaa
    10801 cgacctgctg acctcgcggc tccaccagtt cgagaacacc gccctcaccg aactgggccc
    10861 gctctgcgcg gagaagggcc tcgacccggc gcagaccgct tccgtcctcg cgtacgtcaa
    10921 ggggctccag gactggcagt ccggcggcca cgagtggcac atgcgctcca gccggtacat
    10981 gaacggcggc ggggccggag aggccgtggc gggcttcggc atgtccgccg cctccatcag
    11041 gttcaccctc cgctcggaga cggcacgggc ccgcagccac agccaccggc ccttccagca
    11101 cgtcggcccc tcgatcgtcc ccgacctgaa gctgccgttc tccacgacgc tgagcccgca
    11161 tctggagggg gccaggctcc ggctggtcga ctgggcgcgc cgcatgggca tcctggaggc
    11221 gcagccgggg gtcccgggct cgcacatctg ggacgaggag cggatcctcg cgatcgacct
    11281 ccccctctgc gcggcgggca tccatccgga cgcctcgccg gaggagctgg acatctcctc
    11341 ggcatggctg gcctggggta cgtacggtga cgactggttc cccgtggtgc acgggcggac
    11401 cagggacctg gccggggccc ggctggccaa cgagcggctc tcgctcttca tgccgctgga
    11461 cggcgaggcc gcccccgagc cggtgaacgc gctggagcgg tcgctgggcg atctgtggct
    11521 ccggacggcg gagccgatgg acctggacgc gcggcgcgcc ttccggaccg ccatcgagtc
    11581 gatgaccgag agctggctgt gggagctggc caaccaggcg cagaaccgta tccccgaccc
    11641 ggtcgactac accgagatgc ggcgggcgac cttcgggtcg gacctgacga tgagcctgtg
    11701 ccggctcgcc cacggcagga aggtgcccgc ggcggtctac cggagcggtc cgatgcgctc
    11761 gctggagaac gcggccgcgg actacgcgtg cctgctcaac gacctgttct cgtaccagaa
    11821 ggagatcgag tacgagggcg aggtgcacaa cggcgtcctg gtcgtccaga acttcttcgg
    11881 cgtcgactat ccgacgggcg tgcggatcgt gcacgacctg atggagtccc ggctgcggca
    11941 gttccttcat gtggcggagg tggaactccc ggtgctctac gacgacttcg ctctcgacgc
    12001 cgaggctcgg gaggtgctgg cgggctatgt gcaggagctg aagcactggc tcgcgggcat
    12061 cctcatctgg caccggggct gccgccgcta ccgcgaggag gacctgcgcc gcgggcacgg
    12121 cgccccgcag atcctcgccg ggccgaccgg actcggcacc tcggcggccc aggtgacccg
    12181 gctgatggcg gaactggcgg gcagcagggc gtagttcccg gcccgcggac ggcacggcta
    12241 ccgccgtacg ccgcacggcc cgtcgcgcca cacgcgcggc gggccgttcg ccgtgcccgg
    12301 acactcctgg agcccggacg ctccggtggt cggggagcga ccgtgcgcgc aagagaggcc
    12361 cggcgcggag gggcgccagg cccgaacagg ccgtccggca tattcgggcg gcctatgcag
    12421 tgacgtttca gccctgctgg aacagctcgg cgggcagggg cttcagaagg gtgtagagat
    12481 cgtcggtgat gggccggtcc cagctcgcga tggtcacgag caccccgtcg ctgcggtcga
    12541 actggacgca ggcgatacgg ctctccgaga gcttcacccg gcggacgatc agcaggttgt
    12601 cgccctgcat cacggggacg tcctcgctgc tgacgacctc gatcggctcg tcgttctcca
    12661 gggccagcag cagctgcgcc acctcgaagg gaacctggcc ctcctcggtc tcccgggcgg
    12721 gcgagccctc cgggagattg ccgatgatca tggccgggcc gcggccgccg tacaggtcgt
    12781 aacggaggaa gacgccctgg cagctgccgt cgggcgcggg gagcagaccg gcgcccaggt
    12841 tgccgggcca gtcccccggg tccatggcca ggacatcgaa gtccggaccc gcgggtgttg
    12901 cggcgctgcg gcggcggagg aaggacatgc tgacatggta cgtggcccgg cccacgtcgg
    12961 ggagccgggc ccgggcccgg ctgccgcccc gggccgggcc tcccggccgc cggtgacatc
    13021 gcgcccggca ccctgccctt acccttccgg caccgcgccg gcgcacgttc gggcacaccc
    13081 tcgactcttc cgcgtggaat cggcgcaagt tcctgcacga cgggcccgtg tgccgcatac
    13141 cgttggatca ccgctgtgcc cggtccgccg tggcagcggc gggtgcggga acggcggtgc
    13201 gccgcgagac gggtacggcg atgcgccgga ggagaggaca ggatgacggt ggagggcact
    13261 gtgggcgggc tggaagagcg ggtggcgggg cgcgcgtgga tggtgcgtct ggacccggcc
    13321 gaccggggcg gtacggcggt acgcgtctcg tgcgggcgtc cgggctgcgc cccccaggtc
    13381 ctgccgtccg ccgccgtcgg ccgtaccgcc gccgtcgcgc acctggcgac gcatctgcgg
    13441 gccgcgtcgg ggccccggcc cgaggcgtac tgcgcctgcc gggccgacga ctgccacacc
    13501 catgtgcgga ccgacggccc ccgcgaccgc gccccggcgt cgcggtgcgg gggcccggtc
    13561 gtcctggccg tcatcaacga ccggcagggc cgctggtggc gggccctgga gtgctgcgcg
    13621 cgctgtgcgg ccgcccaccc ctcggcgaag gtcgtcgcca ccgccccggc ggtcgccgca
    13681 ccgtccgccg ccctcgctcc ggcgggtgcg gcccgggccg ccgcgccccg gccgcccgcc
    13741 cagatcggcc cgcagttctc ccacgccgcg tcggccccgg cccccgtccc cgagggggtg
    13801 cccgcggccc gtcccccccg gccccgccgc aagcgccggt ccgggaagat cgcgcagcgg
    13861 atcgtgccgt tcgacctgca ccccgtcgcc ctgcgcgagg agctgatcga gctgggcgat
    13921 ctcttccgcg cctaccagca gcgccccgaa ccggatctgg tcgaactctc cgagctccac
    13981 tcccgcaagg cgaaggcctt ccgcacctgg gcggaggtca cgggtgagac cgaactgcgg
    14041 ctggaggcgg agcgggccga gcaggcggcc gccgccgccc tcctccagca ccagcagcgc
    14101 accggccaga gcccggcggg cgacgggcag gtcaccagcc ggctgctgcc gggcctcacc
    14161 cagtgggacc acgcccgggc gatcctggcc catgtcgccg ggcacacccc ggtgcccggc
    14221 gcggaggccc gtctcctggc ggtgctgctg accctgcgct cggccctcac cggcatcggc
    14281 aacctggtgg ggcaggacgt cagggggctg cccctgacgg atcccgagga gctgatcggc
    14341 cggctcgtgg agagcggctg gctctccttc cccggcacgg tcgaggaact gctcgcctcc
    14401 cgcccggagg accccacccc ggtcaccatc ccgtccctga tgcccgacga ggacggcccg
    14461 ggtccgttcg tcttcggccg caagacccgc cccaagctga gcggttgggc ccaacgggtg
    14521 gtgggtgaca agaagctccg caagaagagg accggcgccg atgtccggct gctggccctg
    14581 gccctggccg tacggaccag cgccgacggg cggctggggc ccgacggcga gggcgtcgag
    14641 gtggaacccc tcgcgtcctg gtgctgcgtc gggcccgagg ggctggagcc gctggtggag
    14701 cagctgacgg tggcggactg gctcaccgat gcggagttca ccgccgacgg cctgctccgg
    14761 gggcggctga ccgaacgggt actgccggtc agctgcccgc tggcctgagc cggtgccggt
    14821 gcctcccggg gtgcgcccgg aaggcccgga tccgggccgt catcccggcg ggggccggga
    14881 gccgacgagc cacatggcga agaactgcgc cccgccgccg taggcgtggc cgaccgcccg
    14941 ggtggccccg tcgatctggt ggtcgcccgc ccgtccccgt acctggagcg ccgcctcggc
    15001 gaagcggatc atgccggagg cgccgatggg gttggtggac agcaccccgc ccgacgggtt
    15061 gacggggagg tccccgtcga gttcggtgac gcccgcctcg gtgagcttcc acccctcgcc
    15121 ctccgcggcg aagccgaggt tctccagcca catcggctcg taccaggaga acgggacgta
    15181 catctcgacg gcgtcgatct cccggcgcgg gtcggtgatc ccggcctgcc ggtagacgtc
    15241 ggcggcacag tcccggcccg cccgcgggga gacgaagtcc ttgcccgcga agagggtggg
    15301 ttcgctgcgc atcgcgccgc cgtgcaccca ggcgggccgg tgcggggccc ggctcgcgcc
    15361 gtcgcggtcg gtgaggacca tcgcgcacgc cccgtcggag gaggggcagg tctcggagta
    15421 gcggatcggg tcccagagca tgggagaggc ctggaccttc tccagggtga ggtccgggtc
    15481 gtggatgtgc gcgtaggggt tcttgagggc gttgcggcgg tccttgtacg cgacgaggga
    15541 gccgaccgtg tcgggggcgc ccgtacggcg catgtacgcg cggacgtgcg gggcgaagaa
    15601 gccgccggcc ccggccagca gcggctgctg gaaggggacg ggcagggaga gcccccacat
    15661 ggcgttggac tcggactgtt tctcgaaggc cagggtcagg acggtccggt ggacgcgggc
    15721 ggcgaccagg ttggccgcga cgagtgcggt ggacccgccg accgaaccgg ccgtgtggac
    15781 gcggagcatc ggcttgccga cggctccgag ggcgtccgcg agatacagct ccggcatcat
    15841 cacgccctcg aagaagtcgg gggccttgcc gatgacgacg gcgtcgatgt cgttccaggt
    15901 cagtgcggcg tcctccaggg cgcggaccgc cgcctcgcgg accagtccgg cgatggagac
    15961 gtcgtgccgg gcggcgacgt gcttggtctg gccgatgccg acgacggcga cgggctcctt
    16021 agtcatgagc gctctcccct tccaggacgg cgaccaggtt ctgctgcagg cagggtccgg
    16081 aggtggcgtg ggcgagggcc cggtcggaca cgccgcggtg gatgcgggcg gcggcctcgc
    16141 cgagccggac gaggcccgcc gccatgatcg ggttggcggc gagggctcct ccggaggggt
    16201 tgacacggac gtcgtcgccg aggtcgaggg acctgcggag gatcacctcc tgcgcggtga
    16261 agggggcgtg cagctcggcg gtgtcgacgg ggcgttcgaa ggctccggcg tgccgggcgg
    16321 cgagccgggt ggagggtgag tcggtgaggt cgcggacgcc gaggccgtgg gcctcgatgc
    16381 ggtggtcgat gccccggatc caggcggggc gggtgcagag ggcgcgggcg gtgtccccgg
    16441 cggcgaggac cacggcggcg gcgccgtcac cgatgggcgg gcagtcgccg gtgcgcagcg
    16501 ggtggacgag gaggtccccg acggggacgt ccccggtgag ctgggcgtac gggttggcgg
    16561 tggcgtcggc gcggctgcgg gtggcgatgg cggtgagggc ggcccggtcg gtgcggccgg
    16621 cgtcgaggag cgcctgggcc tggagggcgg cgagggagac ggagtcgggc cagagggggg
    16681 cgaggtagta ggggtcgagc tggcgggtga ggacgtcgcg gacctggccg ggcgaggatt
    16741 ttccgtacgc gtagacgagc gcggtgtcgg cctcccccgt catgatcttc acccaggcct
    16801 cgtacagcgc ccaggccccg tccatctcga catgggactc ggagatcggg gggtgggcgc
    16861 cgacgccgtc gagcgccatg gtgaaggaga aggcccgccc ggcgaggtag tcggcggagc
    16921 cggagcaggt gaacccgatc tcgttggccc tgaggccggt ggtctccagc acctggtgga
    16981 ggacgggcat cagcaggtcg acctcggaga gttcgtccgt acgccgtcgg tgcgggctct
    17041 gggcgaaggc gacgatcgcc acgtctcgca tctacaccag ctccttgtac gtgtcgtagt
    17101 cggcgtcggg ctccccggtg ggccggtagt ggtccacgtg ccgggtgccc tcggcccaga
    17161 ccggctcgac gcgcagcccc atgcggacct cgtcgtaggg gatgcccgcg atgcggccgt
    17221 gcagggcgag gtcggcgccg tcgagggcga tgtgggcgta gacgtagggg acctcgatgt
    17281 ccaggttctt cgctttgatg ttgacgatgc agaaggtggt gacggtcccg cgtgggccga
    17341 cctcgacctg ttcggcggtg gcgatgccgc aggtggggca ggcgccgcgc ggcggtacgt
    17401 agaccttgcg gcaggcgggg cagcgttcgc cgacggtgcg gcggtcctcc agcgccttga
    17461 ggtaggcgct ctgggcgcgg ccgggggtgt ggacgtagtc caggcgggcg gggacggtga
    17521 tgccggtgac ggggtcggcg aactcccctt cgtggggcgc gggttcggcg gtctccggct
    17581 caccgtcgta cggttcgagg caggcgatgt cggtgatggc tccggtacgg gtggcggccc
    17641 agcggatccg gacgcgcatc ccggtgcgga cggcgtcggg tccaggggcg tccagggcgt
    17701 gcaggagcgc ggtgtcggct ccgtcgaggc ggacgagcac ccaggcgaag ggggtgccca
    17761 ggggctggcc gcggcggggg gaggggttcc aggcccagct ggtgacggtg ccggtggggg
    17821 cgacccggac gagtgagcgg agttcgttcg cggtgacggg gtcgtactcg acgggcggga
    17881 cgagcaccct gccgtcgtcg gtgcggaccc cgaggacggt gcgctcgcgc agtccggtga
    17941 ggaaggcgct ctggacgggg cccagggagc gggtgaaggg gaactcgacc accagcgggg
    18001 cgctgaggat ctcggtcatg gctctctcct aggctcggga gtcagaactc cggcctccgg
    18061 acccggggtt caggacccgg ggcgcggggt caggcgcggc ggtagacggg cgggcgcttc
    18121 tcggcgaagg cgcgggcgcc ctccttggcg tcctcggtgg cgaacacggg ccagccgcgc
    18181 ttgagttcgg cggccagcgc ctcgctctcg gtcagctcgg cgccctcgta gaccgaggcc
    18241 ttgacggcct ccacggcgag cgggccgcag gcgttgatcc gttcggcgac ggcgagggcc
    18301 tcctcgcggg cggtgccgtc gggcacgacg cggccgacga gaccgatcgc cgcggcctcg
    18361 tcggcggtgt acgggcgtcc ggtgagaagc atttcgaggg cgtgggtacg ggggatctgg
    18421 cggggcagcc ggacggtgga gccgccgatc gggaagaggc cgcgccggac ctcgaagagc
    18481 ccgaaggtgg cgcccgcccc ggcgatgcgg atatccgttc cctggaggat ctcggtgccg
    18541 ccggcgacac aggggccctc cacggcggcg atcaccggtt tgcgcgggcg gtggtggcgc
    18601 agcatcgcct tccagtgcag gtccgggtcg gcggtcatcc ggtcgcggta ctcctgcccc
    18661 gccataccgt cgcccgccag tgccttgagg tccatgccgg agcagaacgc gccgcccgcg
    18721 ccggtgagga cgatcgagcg gatcccgtcg tcggcgtcgg ccgcgagcca gccgtcgtgg
    18781 aggccgacga gcatcggcag cgacaacgcg ttcctggcct ccggcctgtt cagggtgagc
    18841 accagtgtgg cgccctcacg ctccacggtc aggtgttccg taccgcccat gacgaactcc
    18901 cctctgcgga cctggaacag gttgcaggag gcggctccac agttcaatag ttttctgact
    18961 gtcagtcaga ttccttcgac gccgcccctt cccacttgtg ccgaccggcg ctctaatgac
    19021 ggccgagtcg ccagtcatcc ggggtcagga ggaacggtgg agtacaacct tgccgacctg
    19081 ttcgagtcgg tcgtggacgt ggtccccgac cgagaggcgc tcctgtacgt cgaccatccc
    19141 ggcacgggcg ccgaacggcg tctcacctac ctccagctgg acgcggccgc caaccggatc
    19201 gcccatcacc tcatcggcgc gggcctacgc ccgggtgaac acctgggcct gcacctgtac
    19261 aacgggatcg agtacctcca gacggtcctg ggagcgctca aggcccgcct ggtgccggtg
    19321 aacgtcaact accgttacgt cgaagaggaa ctggtctacc tctaccggga cgcggatctg
    19381 gccggcctgg tcttcgacgg cgagttcgac gagcgggtgg cggcggcgtc cacgcaggcc
    19441 ccggcgctgc gccatctcat ccgggtgggg tccaccgagc cacccgtgac cccgggggcc
    19501 gtgcccttca ccgaggccga ggcctccggc tcgccagcac gcggcttcgg accccgttcc
    19561 gccgaggacc agttcatcat ctacaccggc ggcacgaccg gtatgccgaa gggggtgatg
    19621 tggcgtcagg aggacctgtt cttctcgggc ctcggcggtg gcgcgccgac gggggagccg
    19681 gtgaagagcc cgcaggagct ggccgagcgg gtggcggcgg gcggcgacgg catcaccttc
    19741 ttccccactc ccccgctgat gcacggcacc tcgacgctca ccgcgttcat cggcttcaac
    19801 ttcggccagc gggtggtcgt acaccgcaag ttcgcgccgg aggaggtgct gaggacgatc
    19861 gagagggaga aggtcaccag cgtctccctg gtgggggacg cgatgctgcg tccgctgatc
    19921 gacgccctca agggaccgct gcgggggacg gactgttcgt cgctgttctc cgtctccagc
    19981 tccggggcga tcatgtcgga ctcggtgcgg gcggagttcc aggcgctggt gccgacggtg
    20041 atgctgctca acaacttcgg ctcctccgag tccggcttca acggcacggc gaccgccgac
    20101 tccggccccg agcgcggctt ccgggtccag gtcaacgccc gtacggcggt ggtcgacccg
    20161 gtgacgtacg agccggtggc cccgggcgag gtcggccgca tcgcgcagcg gggccacgta
    20221 ccgctcggct actacaacga cccggccaag accgccgaca ccttcttcca caaggacggc
    20281 gaacggtggg tgctgctggg cgacatggcg accgtggacg cggacggcat cgtcaccgtg
    20341 ctcggccggg gctcccagtg catcaacacc ggcggcgaga aggtctaccc ggaggaggtc
    20401 gagcaggcgc tcaagtccca cccggacgtg tacgacgcac tcgtggcggg cgtccccgac
    20461 gcacgctggg gcagcagggt cgcggccgtc ctcgaactcc gcgagggagc ggcggcgttg
    20521 gacctggccg cggtccaggc ccactgccgg accaggctcg ccgggtacaa gatcccgcgc
    20581 gccctggtcc tggccgaccg gatccggcgc tccccgagcg gcaaggcgga ctaccgctgg
    20641 gccaaggcgg tggcggcggc cggggcggac ggctgagggg caccgcccac cacaggcggg
    20701 tgccgtcagg ccccgcacgg acacggcgtc gggtggccgg ggcggagctg agcagcacgg
    20761 tcaccccagg ccgaacgacc ggagcgcggc gaggaactcc tccggccggg cggtgtggac
    20821 gaggtggccc gcctcgatgg tgacgaactc ggcgtcgggg atggtgtcgg ccatgcgggc
    20881 cagctgtttc tggtcgacat ggctcgtcgt gccgccgccg atgatcagcg tcggggcggt
    20941 gatctccgcc ggccgttcgc gggccgccgg gtccggggcg ttcagctggg cgtcggtgtg
    21001 cgggacgacg ggccagtcga agtccagctc gcctccggga cgttcggcgg gcgggcgggg
    21061 cgggtcgagc gggaggggcg gtggggcgtc ctcgatgacg agacggccga tgagccccgg
    21121 ttcgcgctgg gcgaggaggt aggcggccac cccgcccatg gagtgcccca cgacggtggc
    21181 gccgggcagg tcgcgggcct ccaggaaggc gtgcaggtcg tcgcggaaga gctcgaagga
    21241 gtagtggccg ggccagtcgc tgagcccgtg gccccggaag tcgggggcgt acacgcggtg
    21301 gtcggcggcc agctccccgg cgatccgcgt ccaggtgagg gaggagtctc cccggccgtg
    21361 gaggaggacg accggcgggg cggcggggtc gccccacacc cggtaggcga gccggacccc
    21421 gcccgccgac acgctccgga cctccccgtc gaggaaggcc gtgaccgtac gggagaaggc
    21481 gcccgggtcg tcgagccacg ggaagtgccc cgcgcccctc tggacggtga actcgccgta
    21541 cgggaagagc gcggccagct ccgccgcccg gtccgggctc gggtggccgt ccagctcgcc
    21601 ggcgagcacg aggaccggcg cggtgagctc gcgcagggcc gggacggtgg tggcggggtc
    21661 gtacgcgccg tcgtcgtagc ggccgcgcgc ctccgcgttg gtctgcgacc cggaggcggc
    21721 ggcgtgggcc ttcgccgccg cgtcccagcg gccgtaggtg agcggccgga cggcgggcca
    21781 cagctcggcg aaggggccgc ccgcgagcag tgcctcctgg gcggcccggg cctcggcgta
    21841 ccagggttcg ccgctgcgca gccgggccgc gtcgcgcagg tcctggtggg tgacggggat
    21901 gccggcggcc tgggtggagg gggtgatcag ggtgagggtg cgcagccgct ccgggtgccg
    21961 ggcggcgtac agctgggcca ggttcgcgcc cgccgagtgg gccagcaggt cgatccggtc
    22021 caggccgagg tgttcgcgca gcgcctccac gtcgtcgacg agccggtcgc accggtaggt
    22081 ggcggggtcg cccggcgcgg cggaggcgcc cgtcccgcgc aggtcgagca ggaccagctg
    22141 ccgcacggcg ccgagcccgc ccagctcccc caggcaggcg ctcgcccgca tcggcccgcc
    22201 gggcaggcag atca
//
