LOCUS       NZ_KB890945            10870 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. CcalMP-8W B053DRAFT_scaffold_4.5, whole genome
            shotgun sequence.
ACCESSION   NZ_KB890945
VERSION     NZ_KB890945.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. CcalMP-8W
  ORGANISM  Streptomyces sp. CcalMP-8W
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 514328)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   2  (bases 1 to 514328)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. CcalMP-8W
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:14:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,603
            CDSs (total)                      :: 6,529
            Genes (coding)                    :: 6,424
            CDSs (with protein)               :: 6,424
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 83 of 105
            Pseudo Genes (internal stop)      :: 5 of 105
            Pseudo Genes (multiple problems)  :: 18 of 105
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:04:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 41349
            Orig. end                         :: 52219
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB890945.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405361
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10870
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10870
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5870](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5870)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    complement(24..40)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     gene            86..439
                     /locus_tag="B053_RS0123705"
     CDS             86..439
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761871.1"
                     /locus_tag="B053_RS0123705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_018491070.1"
                     /transl_table=11
                     /translation="MSPTEPAAASGRPLAHPSVAEIGLEGVLRALADPVRLRIVRGLAD
                     GHPDMACVAFGLPVSKSTTTHHFKVLREAGVIHQRYEGTSRLSRLREADLEERFPGLLT
                     AVLAAARRTSPGA"
     gene            complement(539..1579)
                     /locus_tag="B053_RS0123710"
     CDS             complement(539..1579)
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (19-269). E-value: 3.5e-13.
                     Score: 41.3. Matches aSDomain:
                     nrpspksdomains_B053_RS0123710_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761872.1"
                     /locus_tag="B053_RS0123710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)-dependent alcohol dehydrogenase"
                     /protein_id="WP_018491071.1"
                     /sec_met_domain="ADH_N (E-value: 3.9e-29, bitscore: 95.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.8e-22, bitscore:
                     74.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVAAYAAPRAKAPLERTTIERRPVGEFDVLIEIRFAGICHSDI
                     HQARDGWGEGIFPMVPGHEIAGIVTETGPGVTRFTAGDRVGVGCMVDSCGQCDACRMGR
                     EQHCAEGNTQTYNALDRSGEPTYGGYSTHIVVRESFVVSIPEGIALDEAAPLLCAGITT
                     YSPLRRWGAGPGRKVAVIGLGGLGHMAVKIAHTLGAEVTVLSQSLRKKDDGLKLGADHY
                     YATSDPKTFEELAGTFDIILSTVSAPLDFGAYLALLRTDGTLVNVGAPEEPVSLNLFSL
                     IGGNKSLAGSAIGGIAETQEMLDFCAVHGLGAEIEVIGADQVNEAYERVLASDVRYRFV
                     IDTATI"
     aSDomain        complement(773..1522)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B053_RS0123710_PKS_ER.1"
                     /evalue="3.50E-13"
                     /label="B053_RS0123710_PKS_ER.1"
                     /locus_tag="B053_RS0123710"
                     /protein_end="269"
                     /protein_start="19"
                     /score="41.3"
                     /tool="antismash"
                     /translation="TIERRPVGEFDVLIEIRFAGICHSDIHQARDGWGEGIFPMVPGHE
                     IAGIVTETGPGVTRFTAGDRVGVGCMVDSCGQCDACRMGREQHCAEGNTQTYNALDRSG
                     EPTYGGYSTHIVVRESFVVSIPEGIALDEAAPLLCAGITTYSPLRRWGAGPGRKVAVIG
                     LGGLGHMAVKIAHTLGAEVTVLSQSLRKKDDGLKLGADHYYATSDPKTFEELAGTFDII
                     LSTVSAPLDFGAYLALLRTDGTLVNVGA"
     misc_feature    1646..1661
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.13"
                     /tool="antismash"
     gene            1737..2702
                     /locus_tag="B053_RS0123715"
     CDS             1737..2702
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761873.1"
                     /locus_tag="B053_RS0123715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_018491072.1"
                     /transl_table=11
                     /translation="MDDQPGTSAPEPLDRRAELSEFLRTRRARLRPQDVGLPEFGRARR
                     VPGLRREELAQLAGVSVAYYTRLEQGNGRNVSAEVLDAIARALRLSDAEHAHLTHLAKP
                     GQHKKKRRPARVQRVRTGLLHLLESLEAVPAYVSGARSDILAWNPMAAAVFGDWGALPP
                     EERNWARLVFLSPGYRDLFVEWDTKASDMVSYLRLYAGCHPDDPQLSALVGELSVKNDE
                     FRRLWATHNVKEKGHGVKLLRHPLVGDMALSYETLHLPDDPEQYLVTYHAQPGSESAQA
                     LRLLASWGADAGRTDADRIDPVRGAGRAGLGGGAGRGEGG"
     misc_feature    2738..2751
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.66"
                     /tool="antismash"
     gene            2750..3181
                     /locus_tag="B053_RS0123720"
     CDS             2750..3181
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761874.1"
                     /locus_tag="B053_RS0123720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_018491073.1"
                     /transl_table=11
                     /translation="MEDTKDPYELRAGVPSVELFRRLRTDAGLSDKAPEAVAVALPNTW
                     HGVVLHHRGEPIGMGRIIGDGGTAFQVVDVCVHPAHQGRGLGGRIMAALTEELERRAPA
                     TAYVSLIADGPARFLYEKFGFADTAAHDSIGMYRSMGPS"
     gene            complement(3200..3886)
                     /locus_tag="B053_RS0123725"
     CDS             complement(3200..3886)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515159.1"
                     /locus_tag="B053_RS0123725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_018491074.1"
                     /transl_table=11
                     /translation="MTKQVRAARTRQALIRSAAIVFEQHGYAQARLALISSGAGVSTGA
                     LHFHFENKAAVAQAVVAEASQGLLAVSSSIRRRTDTALQTLVDTSHALVDLLARDPVTR
                     AGFRLSCDGVRGDEPGLPTQWQRCVGELLDEAAAAGTLAEDVSRTDATAATVAATTGFE
                     VLGRYDSEWLSAPTPTGFWRLLLPRLATPETLPLLDPSGTAAATEAVATGPDGHRPSGV
                     GAAAPI"
     gene            complement(4064..4924)
                     /locus_tag="B053_RS0123730"
     CDS             complement(4064..4924)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515158.1"
                     /locus_tag="B053_RS0123730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_018491075.1"
                     /transl_table=11
                     /translation="MILVTGATGAVGGEVARLLAAEGPVRILARRPERVTVHGPGVEVV
                     AGEYADREALDRALRGIDAVFLVTNSPTEPDDSRVATAARAAGVRHLVKLSMMSVEEPG
                     ADDLITRLQRGNEQAVRESGVAWTFVRPRTFMSNTLSWAAGIASDGVVRALYGDSPVAC
                     VDPRDVAAVAVAALTGTGHEGRAYAVSGPEPVTAREQTAHLSEVLGRPLRFEQLPLDRA
                     REALLAKYPRPVAEAFLESAERQRAGAKAAVVPTVEELTGRPARTFRTWASDHAESFTA
                     ADLGV"
     misc_feature    4910..4925
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.49"
                     /tool="antismash"
     gene            complement(5001..5870)
                     /locus_tag="B053_RS0123735"
     CDS             complement(5001..5870)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761876.1"
                     /locus_tag="B053_RS0123735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_086018739.1"
                     /sec_met_domain="AfsA (E-value: 2.1e-26, bitscore: 86.5,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELVHRSRAEDAFPRNWVRLAPDRFLVEAVLPHDHPFFAPVGVDR
                     HDPLLVTEAMRQAAMLAFHAGYGVPVGHHFLMADLDYATHPEHLVVGGLPTVIDVEVTC
                     SELKWRAGLPVQGRVHWVVRRAGQLVATGMGATRFTSPRVYRRMRGGSAQPGVAIPCSV
                     PVDPARAGRDRVEDVVLSRGAREGVWELRVDTRHPTLFQRPNDHVPGMLLLEAARQAAC
                     LAAGDGRFVPAEGRTHFHRYAEFGTPCTIAADVLAGAVPGEARVRVTGRQDGEPVFDSV
                     LTGPSGTI"
     misc_feature    complement(5856..5869)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    5954..5970
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.62"
                     /tool="antismash"
     misc_feature    complement(6012..6032)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.32"
                     /tool="antismash"
     gene            6105..6743
                     /locus_tag="B053_RS0123740"
     CDS             6105..6743
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606642.1"
                     /locus_tag="B053_RS0123740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_018491077.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQAILLAAAETFEKHGYRAATITEILRIAGVTKGA
                     LYFHFPSKEELALGVLEAQEPPPPTPDQPLKLQELVDMGMMFSHRLHTSLLTRAGVRLS
                     MDQQAQGLDRTGPFLRWQQTTHDLLAHAKQNGELLPHVNPMETAGLYVAAFTGIQAVSQ
                     TLTNYRDLEQRYLALQRHILPSIATPSILTALDLTPQRTTDLARLAPAY"
     gene            complement(6779..7390)
                     /locus_tag="B053_RS0123745"
     CDS             complement(6779..7390)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459226.1"
                     /locus_tag="B053_RS0123745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysE/ArgO family amino acid transporter"
                     /protein_id="WP_018491078.1"
                     /transl_table=11
                     /translation="MTNALTTAAAGFGTGLSLIVAIGAQNALVLRQGVRREAVLAVVAI
                     CALSDAVLITLGVAGVGAVVVAWPSALTVVSLLGALFLVGYGLLAARRAFRPSVLLPQD
                     APSGATRGAVLACLAMTWLNPHVYLDTVFLLGSVAADRGPLRWTFGLGAVLASVCWFTA
                     LGFGARLLSGVLARPSSWRVLDGLVAAMMIGLGVRLALTA"
     misc_feature    complement(7390..7405)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.62"
                     /tool="antismash"
     misc_feature    7434..7447
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.0"
                     /tool="antismash"
     gene            7457..8374
                     /locus_tag="B053_RS0123750"
     CDS             7457..8374
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982559.1"
                     /locus_tag="B053_RS0123750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator ArgP"
                     /protein_id="WP_026238063.1"
                     /transl_table=11
                     /translation="MMTELPLDQVRTLLAVVDEGTFDAAANALRVTPSAVSQRVKALER
                     RTGRVLLMRTKPVRPTESGEVVVRFARQLARLEQDAQAALGMAGPGEPTRLTIAVNSDS
                     LATWFLPALGRVPEGLGICYELRREDQDHTAALLREGLVMAAVTSSPEAVSGCSVRSLG
                     RMRYLPVATAAFAARWLGRGTAAPLRELIVDAPVVDFDRRDDIQASFTRALGCGRRAAP
                     RRHFVPTSEGFVDAVAAGMGWGMLPDVHARPLLDSGRLVALAPDRHIDVPLYWQQWKLD
                     SPALATVAEAVAAEAAQALGGGSG"
     gene            8541..9203
                     /locus_tag="B053_RS0123755"
     CDS             8541..9203
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236454.1"
                     /locus_tag="B053_RS0123755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_026238064.1"
                     /transl_table=11
                     /translation="MRVLLVEDDDDLRAVIAAGLREAGFAVDGAEDWPEADVMLHVTAY
                     DCVVLDRMLPSGDSLARLEDRRRAGWAVPVLCLTALDALDERLHGLESGADDYLAKPFV
                     MRELVLRVRSLTRRAAERLPSFLSCADVVMDLARREVRRGGVLLSLSPKEYAVLQQLLV
                     HRGSVVTRTALLERCWDEMADPVSNVVDAVIAGVRRKLGSPPLVRTVRGQGFLLGAP"
     gene            9200..10600
                     /locus_tag="B053_RS0123760"
     CDS             9200..10600
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515152.1"
                     /locus_tag="B053_RS0123760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_018491081.1"
                     /transl_table=11
                     /translation="MNRPRGSGSARRRSPARDRLRRLQLRLTAAYTLITLAGLSCLAWL
                     VIRTDDRSREAAEYDEMRRRASVAASLVYYEDDRIRLDGLADDEATAGTPQILVLEERP
                     GGGPAVVFRGGVQQFDVPATALARAARAATRGQETVRQEAHDRTGGPVRLLAVPFWHDA
                     TDEVAGAAVAVGDPAYGSAEHRSLVLSLVVGCAALTALAALTGHVLSGRSMRPAWQALE
                     QQERLLADAAHELRTPVAVMRGSVELAERRPGGADPYLPGIRRAADRMGHVVENLLTRG
                     RLEAAVEAVRAEPLRLDQLVEEVCAELSEGGHRWELRAVESVVEADAALVRVAVRNLLD
                     NAVRHGRTAGKEAGGPLGHSEREGPASGEPGRADLLVTVDGPEVSVADRGPGVEPGRLP
                     ELIERFRSPGGGTGIGLSLVHRVALAHRGALTVRARPGGGAVFVLRLAPARSRRRRDAG
                     RAGGATGG"
ORIGIN
        1 cgtacgaaat cctcgtagta cggtagttgt caaactacga tgattgtcgt actttcagtg
       61 gcccgtcgga cctccaggag gctccatgtc ccccaccgaa cccgccgccg cgtccgggcg
      121 cccgctcgcc catccgtccg tggccgagat cggcctggag ggtgtcctgc gggcgctggc
      181 cgatcccgtc cggctgcgga tcgtccgggg actcgcggac gggcacccgg acatggcgtg
      241 cgtcgcgttc ggcctcccgg tgagcaagtc gaccaccacc caccacttca aggtgctgcg
      301 cgaggcgggc gtcatccacc agcgctacga ggggacctcc cgcctgagcc ggctgcgcga
      361 ggccgacctg gaggagcgtt tccccgggct gctgacggcc gtgctggcgg cggcgcggcg
      421 gacctccccc ggcgcgtgag cgtgcggggg tgccccgggc ccggtgagga cccggggcac
      481 ccccgcgtgc gtgtgcgggc accctggacg gcgcacccgc gtacggctgc cggaccggtc
      541 agatggtcgc cgtgtcgatc acgaagcggt agcggacatc gctggcgaga acgcgctcgt
      601 acgcctcgtt gacctggtcc gcgccgatca cctcgatctc ggcgccgagg ccgtgcacgg
      661 cgcagaagtc gagcatctcc tgcgtctccg cgatgccacc gatcgccgag cccgccagcg
      721 acttgttgcc gccgatgagc gagaagaggt tgagcgagac cggctcctcg ggcgcgccca
      781 cgttgacgag ggtgccgtcc gtgcgcagca gggcgaggta ggcgccgaag tccagcgggg
      841 cggagaccgt ggagaggatg atgtcgaagg ttccggccag ctcctcgaag gtcttcgggt
      901 cgctggtcgc gtagtagtgg tcggcgccca gcttgagccc gtcgtccttc ttgcgcaggg
      961 actgggagag gaccgtgacc tcggcgccga gggtgtgcgc gatcttgacg gccatgtggc
     1021 cgagaccgcc gaggccgatg acggcgacct tcctgccggg gccggcgccc cagcggcgga
     1081 gcggggagta cgtggtgatg cccgcgcaga gcagcggcgc ggcctcgtcc agggcgatgc
     1141 cctcggggat ggagacgacg aagctctcgc ggacgacgat gtgcgtcgag tagcccccgt
     1201 acgtcggctc gccgctgcgg tcgagggcgt tgtacgtctg ggtgttcccc tcggcgcagt
     1261 gctgttcgcg gcccatgcgg caggcgtcgc actgtccgca ggagtcgacc atgcagccga
     1321 cgccgacgcg gtcgccggcc gtgaagcggg tgacaccggg gccggtctcg gtgacgatcc
     1381 cggcgatctc gtggccgggc accatcggga agatgccctc gccccagccg tcccgggcct
     1441 ggtggatgtc ggagtggcag atgcccgcga acctgatctc gatgaggacg tcgaactcgc
     1501 ccaccgggcg gcgctcgatc gtggtgcgct ccagcggggc cttggcacgg ggagcggcgt
     1561 aggcggcaac ggtggtcatg ccggaggttc tcctctgggt gatgcggtag gaacgaacgt
     1621 catccagcat cacgggaccc gcggcgttta cccaggtcac caccttgcct acgtctgccg
     1681 gtcctactcc tggcagggac aggctcctgt gcgtacgacc aggaataatg ggagccatgg
     1741 acgatcagcc aggcacctcc gcccccgagc cgctcgaccg gcgcgccgaa ctcagcgagt
     1801 tcctgcgcac ccggcgcgcc cggctccggc cgcaggacgt ggggctgccg gagttcgggc
     1861 gggcccgccg ggtgccgggg ctgcggcggg aggagctggc gcagctggcc ggggtctccg
     1921 tggcgtacta cacccggctg gaacagggca acgggcgcaa cgtgtcggcc gaggtgctcg
     1981 acgcgatcgc ccgggcgctg cggctcagcg acgccgagca cgcgcatctg acccatctgg
     2041 ccaagcccgg gcagcacaag aagaagcgcc gtccggcccg agtgcagcgg gtgcggaccg
     2101 ggctgctcca tctcctggag agcctggagg ccgttcccgc gtacgtcagc ggggcgcgct
     2161 ccgacatcct ggcctggaac ccgatggcgg cggcggtgtt cggtgactgg ggcgcgctgc
     2221 cgcccgagga gcgcaactgg gcacggctgg tgttcctctc ccccggctac cgggacctgt
     2281 tcgtggagtg ggacaccaag gcctcggaca tggtcagcta tctgcgcctg tacgcgggat
     2341 gccacccgga cgatccgcag ctctccgcgc tggtgggcga actctcggtc aagaacgacg
     2401 agttcaggcg gctgtgggcc acgcacaacg tcaaggagaa gggccacggc gtcaagctcc
     2461 tgcggcatcc gctcgtcggg gacatggccc tctcctacga gaccctgcac ctgccggacg
     2521 acccggagca gtatctggtc acctaccacg cgcagccggg ctccgagtcg gcccaggcgc
     2581 tgcgcctgct ggcgagctgg ggcgcggacg cgggacggac ggatgcggac cggatcgatc
     2641 cggtccgcgg ggccggccgg gccgggctcg gcggcggggc gggccggggc gagggcggct
     2701 agcgcggccg ggggctccct gccgttgcgg ggcctctatt gtgtaataca tggaagacac
     2761 caaggaccct tacgaactcc gggcgggcgt gccctccgtc gaactcttcc gccgactgcg
     2821 caccgacgcc gggctctccg acaaggcccc cgaggcggtg gcggtcgccc tgcccaacac
     2881 ctggcacggc gtggtgctcc accacagggg cgagccgatc ggtatggggc ggatcatcgg
     2941 cgacggcggc accgcgttcc aggtggtcga cgtctgcgtg caccccgcgc accagggccg
     3001 gggcctcggc gggcgcatca tggccgcgct caccgaggag ctggagcgcc gggcgcccgc
     3061 caccgcgtac gtctccctga tcgcggacgg gcccgcgcgc ttcctgtacg agaagttcgg
     3121 cttcgccgac accgccgcac acgactccat cggcatgtac cgctcgatgg gcccgtcctg
     3181 aacctcccgc acccgcaggt cagatggggg cggcggcccc caccccggac ggccggtgac
     3241 cgtccgggcc cgtggcgacg gcctccgtcg ccgccgcggt gcccgaggga tccaggaggg
     3301 gcagggtctc cggggtggcg aggcggggca gcaggagccg ccagaagccg gtgggggtgg
     3361 gggcggagag ccactcggag tcgtaccgcc cgagcacctc gaacccggtg gtcgcggcca
     3421 ccgtggcggc cgtggcgtcc gtacgggaga cgtcctcggc gagggtgccg gcagcggccg
     3481 cctcgtccag caactcgccc acacagcgct gccattgggt gggcaggccc ggttcgtcgc
     3541 cccgcacccc gtcacagctg agccggaagc cggcccgggt gaccgggtcg cgggcgagga
     3601 ggtcgaccag ggcgtgggag gtgtcgacca gggtctgcag ggccgtgtcc gtccggcggc
     3661 ggatggagct ggacaccgcc agcaggccct gcgaggcctc cgccaccacg gcctgggcga
     3721 ccgcggcctt gttctcgaag tggaagtgca gcgcacccgt gctgaccccc gcgccggaac
     3781 tgatcagcgc caggcgcgcc tgcgcgtacc cgtgctgctc gaacacgatg gcggcggagc
     3841 ggatcagggc ttggcgggtg cgcgcggcgc gcacctgctt ggtcaccgga gcctccgccg
     3901 gggggagaag cggatgggaa gggggcctgg gccaggggcc gcgagggccg ggcactctcc
     3961 gccggagcgg gcaagcagcg tcatgggaat atcaaaccaa cttaccggtt tgatttccag
     4021 gggaacgtgt gcgcggtcgg ccaccgtgcg ggcgcgcgtt ccgctagacg cccaggtcgg
     4081 ccgcggtgaa ggactccgcg tgatccgacg cccaggtacg gaatgtcctg gccggacggc
     4141 ccgtcagctc ctcgacggtg ggcaccacgg ccgccttggc accggcgcgc tggcgctcgg
     4201 cgctctccag gaacgcctcg gccacggggc gcggatactt cgcgagcagg gcctcgcgcg
     4261 cccggtccag gggcagttgc tcgaagcgca gcggccggcc cagcacctcc gagaggtggg
     4321 ccgtctgctc gcgagcggtg acgggctccg ggccggacac cgcgtaggcc cgcccctcat
     4381 ggcccgtgcc ggtgagggcg gcgaccgcca ccgccgcgac atcccgcggg tcgacacacg
     4441 cgaccgggga gtcgccgtac agggctcgca ccacgccgtc cgacgcgatg cccgcggccc
     4501 aggagagcgt gttggacatg aaggtcctgg ggcggacgaa cgtccaggcg acccccgatt
     4561 cccgtacggc ctgttcgttg ccccgctgga gacgggtgat caggtcgtcg gcgccgggct
     4621 cctccaccga catcatcgac agcttcacca gatggcgcac gcccgccgcg cgcgcggccg
     4681 tcgcgaccct cgagtcgtcc ggttccgtgg ggctgttggt caccaggaac accgcgtcga
     4741 tcccccgtag cgcccggtcg agcgcctcac ggtccgcgta ctcccccgcc acgacctcca
     4801 caccggggcc gtgcaccgtc acgcgttccg gccgcctcgc aaggatccgt accgggccct
     4861 cggccgccag cagtcgcgcg acctcaccgc cgaccgcccc ggtcgcccct gtcaccagaa
     4921 tcacgtcacg tactcctcat gaaccgccag cgggccgccg cagggccgcc cgtcgccacc
     4981 gcgccgtccg gacgcgtgcc tcagatggtg cccgacggac ccgtcagcac cgaatcgaag
     5041 accggctcgc cgtcctgacg gcccgtcacc cggaccctgg cctcgcccgg cacggcgccc
     5101 gccaggacgt ccgcggcgat cgtgcacggg gtaccgaact ccgcgtaccg gtggaagtgc
     5161 gtacgcccct cggcggggac gaacctgccg tccccggcgg ccaggcacgc cgcctgacgg
     5221 gccgcctcca gcagcagcat gcccggcaca tgatcgttgg ggcgctggaa gagcgtcggg
     5281 tggcgggtgt ccacccgcag ctcccagacc ccttcgcgcg cgcccctcga cagcaccacg
     5341 tcctcgaccc ggtcgcggcc cgcccgggcg gggtcgaccg gcaccgagca cggtatcgcc
     5401 acgcccggct gcgccgatcc gccgcgcatg cgccggtaga cccgcgggct ggtgaacctg
     5461 gtcgcgccca tccccgtcgc gaccagctgc ccggcgcggc gcaccaccca gtggacccgg
     5521 ccctgcaccg gcagcccggc acgccacttc agctcggagc aggtcacctc gacgtcgatc
     5581 acggtgggca gaccgcccac gaccaggtgc tcggggtggg tcgcgtagtc cagatccgcc
     5641 atcaggaagt ggtggccgac ggggactccg tacccggcgt ggaaggccag catcgcggcc
     5701 tgccgcatcg cctccgtcac caacagcggg tcatggcggt ccaccccgac cggggcgaag
     5761 aaggggtggt cgtgcggcag caccgcctcc acgaggaacc ggtccggggc cagccgcacc
     5821 cagttgcgcg ggaacgcgtc ctccgccctg ctccggtgga ccagttccat gggcaccgga
     5881 tgcgccactc ggggctccgg acccacggct gacgccgcta caggatcggt caaaactgct
     5941 gcttcgggca taactccccc caggggttat gtgatgggcg agccgttcct gcggtgcaca
     6001 cgcgctgata agatacagac taagcggttt tttttctatc cccaggaccc tcacaaaccg
     6061 cccgcccggc ccacgtccgg cacagcccca cgaaggagac agggatggcc aagcaggacc
     6121 gggcgatccg cacgcgccag gcgatcctgc tggccgcggc ggagactttc gagaaacacg
     6181 ggtaccgggc cgcgaccatc acggaaatac tgagaatcgc cggggtgacg aaaggcgcgc
     6241 tctatttcca tttcccgtcc aaggaggaac tcgcgctcgg ggtgctggag gcgcaggagc
     6301 ccccgccgcc cacccccgac cagccgctca aactccagga actggtggac atggggatga
     6361 tgttcagcca ccgcctccac accagcctcc tcacccgcgc cggcgtccgg ctctccatgg
     6421 accagcaggc ccaggggctg gaccggaccg gtccgttcct ccgctggcag cagaccaccc
     6481 acgacctcct ggcccacgcc aaacagaacg gcgaactcct cccgcacgtc aaccccatgg
     6541 agacagccgg cctctacgtc gcggcgttca ccggcatcca ggcggtctcc cagaccctga
     6601 ccaactaccg cgatctggaa cagcgttacc tcgcactcca gcgtcacatc ctccccagta
     6661 tcgccacacc ctccatcctc actgcactcg acctcacccc ccagcgcacc accgacctcg
     6721 cccggctcgc gcccgcgtac tgaccgcccg accctccgga ggccgggcgg tcaggcggtc
     6781 aggcggtcag ggccagtcgg acgccgaggc cgatcatcat cgcggcgacc agcccgtcca
     6841 gcacccgcca cgacgacggg cgggccagca ccccgctcag cagccgggcg ccgaagccga
     6901 gggcggtgaa ccagcacacg ctggccagga ccgcgcccag cccgaaggtc cagcgcagcg
     6961 gcccgcggtc ggcggcgacg gagcccagca ggaagacggt gtccaggtag acgtgcgggt
     7021 tgagccaggt catcgcgagg caggcgagca cggcaccccg cgtcgccccg gagggcgcgt
     7081 cctgcggcag gaggacggag gggcggaagg cccggcgcgc ggccaggagg ccgtaaccga
     7141 ccaggaacaa cgcgcccagc agggagacca ccgtcagggc ggagggccag gccacgacga
     7201 cggccccgac cccggcgaca cccagggtga tgaggaccgc gtcggacagc gcgcagatgg
     7261 cgaccaccgc gagaaccgcc tcccggcgga cgccctggcg caggacgagg gcgttctggg
     7321 cgccgatggc gacgatgagg gagaggccgg taccgaaccc ggcggccgcg gtggtcagag
     7381 cgttggtcat ggaccagacg ttagagagcc tcgttacccc tgtacagcta aagattcttc
     7441 actatcatta gcttttgtga tgacggaact ccccctcgat caggtgcgga ccctcctggc
     7501 cgtcgtcgac gaaggcacct tcgacgccgc ggcgaacgcc ctgcgggtga cgccgtcggc
     7561 cgtcagccag cgggtgaagg ccctggagcg gcgcaccggc cgggtgctgc tgatgcggac
     7621 gaagccggtg cggcccaccg agtccggcga ggtcgtggtc cgcttcgccc gacagctggc
     7681 ccggctggag caggacgcgc aggcggccct cgggatggcc ggccccggcg agccgacccg
     7741 gctgacgatc gcggtcaact ccgactcgct ggccacctgg ttcctgcccg ccctcggccg
     7801 ggtgccggag ggactgggca tctgctacga gctgcgccgg gaggaccagg accacaccgc
     7861 cgcgctgctc cgcgaggggc tggtgatggc cgcggtgacc tcgtccccgg aggcggtgag
     7921 cgggtgctcg gtgcggagtc tggggaggat gcgctatctg ccggtggcga cggcggcctt
     7981 cgcggcgcgg tggctcgggc gggggacggc ggccccgctg cgcgagctga tcgtggacgc
     8041 gccggtggtg gacttcgacc ggcgcgacga catccaggcc tccttcaccc gggccctcgg
     8101 atgcggacgg cgggcagccc cgcgccgtca cttcgtcccc acctcggagg ggttcgtgga
     8161 cgccgtggcg gcggggatgg gctgggggat gctccccgac gtccatgccc gcccgctgct
     8221 ggactccggc cggctggtcg ccctcgcccc ggaccggcac atcgacgtcc ctctgtactg
     8281 gcagcagtgg aagctcgact caccggccct ggcgaccgtg gccgaggccg tggcggcgga
     8341 ggccgcacaa gcgctcggcg gtggcagcgg ctgaacgcgg gcgggcgacc gggaacgcgc
     8401 gcaagcacgg gccgcggccg accgggaagg cggacggggc gggccacgcc ttaggatggc
     8461 gggtcttccc ccaggtcggg ctgccggtgc cggcacggcg gcggtgcggg gccggccccg
     8521 agcgacccgg aggtgtctcc ttgcgcgtgc tgctggtgga ggacgacgac gacctgcggg
     8581 cggtgatcgc agccgggctg cgcgaggccg ggttcgccgt ggacggggcc gaggactggc
     8641 cggaggcgga cgtgatgctc catgtcaccg cgtacgactg cgtggtcctg gaccgcatgc
     8701 tgccctccgg cgactccctc gcacggctgg aggaccggcg ccgggcgggg tgggcggtgc
     8761 ccgtgctctg cctcaccgcc ctggacgctc tggacgagcg gctgcacggg ctggagagcg
     8821 gggccgacga ctacctcgcc aaacccttcg tgatgcgtga actcgtcctg cgtgtacgga
     8881 gtctgacccg gcgggcggcc gagcggctgc cctccttcct gagctgcgcc gacgtggtga
     8941 tggacctggc ccggcgcgag gtgcggcggg gcggggtgct gctctcgctg agcccgaagg
     9001 agtacgccgt gctccagcag ctcctggtcc accggggcag cgtcgtcacc cgtacggcgc
     9061 tgctggagcg ctgctgggac gagatggccg acccggtctc caacgtggtg gacgccgtca
     9121 tcgccggggt gcggcgcaag ctgggctccc cgcccctcgt acggaccgtg cgcgggcagg
     9181 ggttcctgct gggcgccccg tgaaccggcc gcggggctcc gggtcggcac ggcgccgctc
     9241 ccccgcccgg gaccggctgc gccggctcca gctgcgcctg accgccgcgt acacgctgat
     9301 caccctcgcc ggactgagct gcctggcctg gctggtgatc cgtaccgacg accggtcgcg
     9361 ggaggccgcc gagtacgacg agatgcgccg ccgggcctcc gtcgcggcct cgctcgtcta
     9421 ctacgaggac gaccgcatcc ggctcgacgg cctggccgac gacgaggcga cggcgggcac
     9481 gccccagatc ctggtgctgg aggaacggcc cgggggtggc ccggccgtgg tgttccgggg
     9541 cggcgtccag cagttcgacg taccggccac ggcactcgcc cgggcggcgc gtgcggcgac
     9601 gcgcgggcag gagaccgtgc ggcaggaggc ccacgaccgt acgggcgggc ccgtccggct
     9661 gctggccgtg cccttctggc acgacgcgac cgacgaggtg gcgggcgcgg ccgtcgcggt
     9721 cggggacccg gcgtacgggt cggccgagca ccgcagcctg gtcctctccc tggtcgtcgg
     9781 gtgcgcggcc ctcaccgccc tggccgcgct caccgggcat gtgctctccg ggcggagcat
     9841 gcggcccgcc tggcaggcgc tggagcagca ggagcggctg ctcgccgacg cggcgcacga
     9901 gctgcggacg ccggtggcgg tgatgcgcgg ttcggtggag ctggccgagc gccgtcccgg
     9961 tggggcggac ccgtatctgc cggggatccg ccgggcggcc gaccggatgg gccacgtggt
    10021 ggagaacctg ctgacccggg gccggctgga ggccgccgtg gaggcggtac gggccgagcc
    10081 actgcgcctg gaccagctcg tggaggaggt ctgcgccgaa ctgtccgagg gcgggcaccg
    10141 gtgggagctg cgggcggtgg agtcggtggt cgaggccgac gcggcgctgg tccgggtggc
    10201 cgtgcgcaac ctgctcgaca acgccgtgag acacggccgg acggccggga aggaggcggg
    10261 cgggccgctc gggcactccg aacgcgaggg tcccgcgtcc ggggagcccg gccgggccga
    10321 tctcctggtg accgtcgacg gtcccgaggt gtcggtggcc gaccggggtc cgggggtgga
    10381 gccgggtcgg ctgccggagc tgatcgagcg cttccgttcg ccgggcggcg gtacgggcat
    10441 cgggctctcg ctggtgcacc gggtggccct cgcccaccgg ggcgctctga ccgtccgcgc
    10501 ccggcccggt ggcggtgcgg tgttcgtgct gcggctcgcg cccgcccgtt cgcggcgcag
    10561 gagggatgcg gggcgggcgg gcggggcgac cggagggtga cgctcacgat tcgctcatga
    10621 tcggccgtcc atgatgcagg ggcaggtacg cagaccacgc ccgggagtcc ccatgtccaa
    10681 gcacgccgcc acccccttcc tccgccgcag gtcgaccctc gcggccctgg ccggcggggt
    10741 cgccgtggcg gccggcgcgg gggtcctgct ctccagcgcc ttcgctgcca agcccgcgcc
    10801 gaaggtcgtc ctcccgcagg cgaacgccgc cttcgactac cagatcggcg gggcctacac
    10861 cccgcccgcc
//
