LOCUS       NZ_KB890938            25269 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. CcalMP-8W B053DRAFT_scaffold_3.4, whole genome
            shotgun sequence.
ACCESSION   NZ_KB890938
VERSION     NZ_KB890938.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. CcalMP-8W
  ORGANISM  Streptomyces sp. CcalMP-8W
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 604003)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   2  (bases 1 to 604003)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. CcalMP-8W
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:14:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,603
            CDSs (total)                      :: 6,529
            Genes (coding)                    :: 6,424
            CDSs (with protein)               :: 6,424
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 83 of 105
            Pseudo Genes (internal stop)      :: 5 of 105
            Pseudo Genes (multiple problems)  :: 18 of 105
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:04:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 93138
            Orig. end                         :: 118407
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB890938.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405361
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25269
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25269
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25269
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15269](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15269)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(29..1258)
                     /locus_tag="B053_RS0120965"
     CDS             complement(29..1258)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379654.1"
                     /locus_tag="B053_RS0120965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_018490572.1"
                     /sec_met_domain="p450 (E-value: 3.1e-17, bitscore: 57.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRIALDPFVSDLDGESAALRAAGPLAEVELPGGVHVYAVTHHAE
                     ARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPGRSMLTVDGADHRRLRTLVAQA
                     LTVRRVERLREGIEALTNASLEKLAAHPAGEPVDLKAAFAYPLPMNVISELMGVDAADH
                     PRLKELFEKFFSTQTPPEEVPQMMADLGTLFTKIVNDKRANPGDDLTSALIAASENGDH
                     LTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKVVNGEIGWDGVIEETLRW
                     NTPTSHVLIRFATEDIEVGDRVLPKGEALIVSFAALGRDERQYGPTAGEFDATRTPNRH
                     IAFGHGPHVCPGAALSRLEAGIALPALYEKFPELELAVPASELRNKPIVTQNDLYELPV
                     KLGCPFGHEG"
     gene            complement(1255..2511)
                     /locus_tag="B053_RS0120970"
     CDS             complement(1255..2511)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967210.1"
                     /locus_tag="B053_RS0120970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_026237978.1"
                     /transl_table=11
                     /translation="MPSGCPVAHRSVPLSGPRFQSDPVQLYRDMRRDHGAVAPVVLDGG
                     VPAWLVLGYRELHQVTGDPVLFSRDSELWNQWDRIPADWPLLPMIGRGQNSILYTVGER
                     HSVRAMMISNALEGVDPFSLKRYAEEFADGLIDRFCTKGAVDIIAEYAKLLPALVLARI
                     YGFSDEEAYPLVGAINDMIDGRERALAGQQHLATSMFRLLADKHAEPGDDVASRMLADT
                     GGFTDEEVAQDLMVMMAAGHQPTADWMGNSLRLMLTDERFAASLSGGRHSVAEAMNEVL
                     WEDTPTQNVAGRWASRDTHLGGRHVRAGDLLLLGIAAANGDPQVRTHASALTGGNNAFL
                     SFGHGEHRCPFPAQETSEVIARTGIEVLLDRLPDVDLAIPAEQLTRRPSPWLRGLTDLP
                     VLFTPTPALGRPGSHGGPA"
     gene            complement(2694..3377)
                     /locus_tag="B053_RS0120975"
     CDS             complement(2694..3377)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071692.1"
                     /locus_tag="B053_RS0120975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_018490574.1"
                     /transl_table=11
                     /translation="MDSATSDRATLSDTADNGLKIVVVGGFGVGKTTMVRSVSEIRPLN
                     TEETMTRAGEAVDHLDGVQAKTSTTVAFDFGRITLDARSVLYLFGAPGQERFWFLWDRL
                     FSGTLGAVVLVDTRRLADSWYAIDRLEHHGTPFIVACNDFGGPLHSEQQIREALDLADD
                     VPLVECDARDRSSSKYVLITLVEHLAALSAARLRAPGADAPGAAVPGSAVPAAALAGPT
                     PEPAP"
     gene            complement(3358..3729)
                     /locus_tag="B053_RS0120980"
     CDS             complement(3358..3729)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610481.1"
                     /locus_tag="B053_RS0120980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_018490575.1"
                     /transl_table=11
                     /translation="MTTAPRPRPGRDDDPDRLYTLTGGRSRSDSAAFDLVTLVVAECDP
                     APGMQSEHVAILRMCQSPTAVVEISATLNLPVSIVRIMLCDLLDTGRVSARHPRTARVA
                     DRLPDPDILEQVLVGLRNL"
     gene            complement(3726..4148)
                     /locus_tag="B053_RS0120985"
     CDS             complement(3726..4148)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510830.1"
                     /locus_tag="B053_RS0120985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_018490576.1"
                     /transl_table=11
                     /translation="MTATTDEKLNWLLEGLLDRTPGTRHALVLSRDGLKLCRTPELSVD
                     QADQLAAISAGIQSLSHGASIEFGDGSGGVRSAMAEFYGGVLFIVEAGAGAHLAVVADE
                     DSDVGLVGHNMSELVEQLGEHLVAPPRTPVAESSAV"
     gene            complement(4145..5758)
                     /locus_tag="B053_RS0120990"
     CDS             complement(4145..5758)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379651.1"
                     /locus_tag="B053_RS0120990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_018490577.1"
                     /transl_table=11
                     /translation="MRPSFRPTALALLISAAVTGALTLWAVVAAPDAVRTPLAWGAAGA
                     AVLLSICVAVTVHTLGTVRALRAQRAADNQRFTAETSRLVSASAAEAQRFTAETARIKA
                     AASAETARVTAEARAENERTAAEAAAEKARLSVTVDRLTARATRAETERSAAVAACANA
                     AGRMQALATSMLADLREMEHRHTDESVLGDLLHLDHRTAQAGRLADSIAVLTGARSGRR
                     WAKPIVMESILRGAMGRIGSYQRVRLHSTSDVAIAGHAAEGVMHALAELLDNAANFSPP
                     TAEVHVYVEEVPAGIVITVEDSGLVMSEVQLRRAEQAVSADHQNLTNLSGTRLGLAVVG
                     RLARKHGLTVSFRPSARGGTGALMMLPQDLISRTAAPAALPDRAPATPPAAATAPAALP
                     AATPSAAPAPTAAPAEPEPSHASAEGAGRSGTVPAARSTAENQASDGSTPLTPAAEPRR
                     TESESESTGGVPAFGESGLPKRRRGRTLAAAEARNGNAAHGGADTPQARTTDAKVQAAR
                     FSTFSRAVRANSPHPEGNTR"
     misc_feature    5842..5855
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.42"
                     /tool="antismash"
     misc_feature    5935..5944
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.63"
                     /tool="antismash"
     misc_feature    complement(5935..5948)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.12"
                     /tool="antismash"
     misc_feature    5935..5949
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.81"
                     /tool="antismash"
     gene            6009..9083
                     /locus_tag="B053_RS0120995"
     CDS             6009..9083
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057296.1"
                     /locus_tag="B053_RS0120995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding and (Fe-S)-binding domain-containing
                     protein"
                     /protein_id="WP_018490578.1"
                     /transl_table=11
                     /translation="MAELHRPHTGPSAPPAGFVAALRAAVRGETGFGPTARALTTMDAS
                     NYRRVPLGVLAPRDADDIAAALTVCREYGVPVVPRGGGTSIAGQATGTGLVLDLTRHLN
                     AILGLDPAARTATVQPGVVLDDLRAAAAPHGLTFGPDPSTHSRCTLGGMIGNNSCGAHS
                     VAWGTTADNVTALEVVRYGGEALRLERTRGTGPDGTRGTSPQGPDGTRGTSSHGPHGVS
                     ELIGAHLALLRTGYPRLPRRISGYALDALLPEHPGGPDPVRAFCGSEGTLAVVTEATVR
                     LVETPRARALAVLGYADEAAAAEAVPGLLPYGPLTVEGMAADLVRKPAGLPRGAAWLFV
                     ETGGATPAEARAHAERVLRSADAVDGAVVTDPAGQRALWRIREDAAGTATRMPDGTEAW
                     PGWEDCAVPPDRLGPYLRDFRALLAGHALRGTPYGHFGEGCIHVRIDFDLLTPSGIARF
                     RGFSEELADLVVAHGGSLSGEHGDGQARAELLPRMYGDELVGVFGAFKDLWDPDGGLNP
                     GILTRPAPLDANLRFAVLPKRPVDVAFGYPQDGGDFAGAVRRCVGVAKCRTTEAPGGGA
                     GVMCPSFRATGEEAHSTRGRARLLHEMLAGEVITDGWRSTEVRDALDLCLSCKGCRSDC
                     PVGVDMATYKAEFLHHHYRGRIRPAAHYALGRLPQWLRLAAPFARPLNALARVRPLAAL
                     AKRLAGIAPERTIPVLATETYSRWLRGHQSEGQGERKGRGLSNGQSEGLSKGLSNGQSR
                     GQGERRNDGEGGRQDGEGTRVPFPGGVVHLWADTFTEFLSPQVGRAAVRVLEEATGRTV
                     LPPPDGVCCGLTYVSTGQLDAARRVMRRTLDRLAPLPGDPVVVLEPSCAAALRTDLPEL
                     LPDDPRAAELAARVRTLAQYLEEHAPDWAPPRLDRPVVGQTHCHQHAVLGDAAERRLRE
                     RMGLTGELSGGCCGLAGNFGFEKGHWEVSVACAEEQLLPSVRESEPGAELLADGFSCRT
                     QLDRLGPPAGRRARHLAEVIAEALEDGAGERRSRR"
     gene            9111..9662
                     /gene="cpt"
                     /locus_tag="B053_RS0121000"
     CDS             9111..9662
                     /codon_start=1
                     /gene="cpt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091418.1"
                     /locus_tag="B053_RS0121000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chloramphenicol phosphotransferase CPT"
                     /protein_id="WP_234018013.1"
                     /transl_table=11
                     /translation="MKTQVIVLNGGSSSGKSGIARCLQALLPDPWLTLGTDTMVEAMPA
                     ALQAAETGIVFGPDGSVSIGSEFWELEDAWTEGVAAMARAGARIIVDEVFLSGAAGRRR
                     WSERLDGLGVLWVGVRCAGEVAAGREIARGDRTVGMAAAQAESVHRGVVYDLEVDTTRT
                     ESLDCARTIAAHVKGEEAGR"
     gene            complement(10001..10993)
                     /locus_tag="B053_RS0121005"
     CDS             complement(10001..10993)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961919.1"
                     /locus_tag="B053_RS0121005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_018490580.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 3.5e-32, bitscore:
                     107.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDQLTQASEPSPTQHAVLAVLTGLPLRDAARQYRMDPVVLSDA
                     VAVYNQAGREALVRQAATTDWWQTYLHFTDWSNADSTFATRVLPILREAEAADAIDGWW
                     YTRKHPCWRLRLRIQPVNGAKRTIEDGFDRLVSEGHLQRWWPGIYEPETLAFGGKTSMT
                     AAHALFVTDSRKIQQLRLRDDLAIGPRELSVLLCTIMMRAARLEWYEQGDVWDRIITTE
                     HRSAVSDVPPEQLNARALEIRPLLLANSDTLLRPGGPLEPVVEWVAAFHSAGQALANGV
                     QDGTLDRGLRQVLSYHVIFHWNRLGLSLRGQSILARAARGAVLQDESPW"
     gene            complement(10975..12207)
                     /locus_tag="B053_RS0121010"
     CDS             complement(10975..12207)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490581.1"
                     /locus_tag="B053_RS0121010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_018490581.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-37, bitscore:
                     123.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLATTAATILEQYTADLAEPPLPPPEEPWAVQSLAAGAAGISL
                     LHIEIASRYGGSWRSAHRWITSAASGAISAADQTGLFLGAPAVGFVLTAVPPAYQHLYA
                     SARTTLHQHITDLANRRVDAALARIGRGDLPTFAEYDLFYGLTGIGAYFLRTEPEGPAL
                     ERILQYLVGLTRPLGSDGRGLPGWWVRHDPARGESPHFPGGHGNFGAAHGITGPLLLLA
                     QAMRRGVTVHGHQDAMFAICAHLDAWCQHGDSGPWWPEHISRRDLDRSQPHHDAPARPS
                     WCYGMTGIARAGQLAGIALRSPTLQKFYEDALYRALSDPAQLALVTDSGLCHGWAGIYQ
                     TAHRAAADALDARLRILPGRLGNALTIPGQPGTSSTPGLINGAAGTALALTTFASKQAP
                     STGWDACLLIN"
     gene            complement(12204..15269)
                     /locus_tag="B053_RS0121015"
     CDS             complement(12204..15269)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380186.1"
                     /locus_tag="B053_RS0121015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_018490582.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.3e-202,
                     bitscore: 667.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 4.7e-17,
                     bitscore: 57.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.3e-08, bitscore:
                     28.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTRAVADYRWQGAAMLRATTSTGPADIPRTLDLDSVAVTREWLN
                     RVWECDGFRNALELATPVLSDAIEAVVQGRQSEPRHVRRTAVSTVSYLLRWQHRPTPLG
                     LFAGTAPVTVGPRASARWRDKHRVLIRPDSEWVTDMVLRLQRIPALLARLPLVANNAAR
                     TRGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAVMDAARTPIAYGALYGHLRDSFPQ
                     ATPEQIDALLTSLVEQRFLITSLWAPMTTVDPLQHLCHELEQRDADSIPGVRDLVHELY
                     ALRDELSAHQPMLSDISVSALATRMRALTAVTPTPLLIDTALDCETQLPHAVIAEAQAA
                     VSALYRTTAQPYGYQHWRDYHRRFRARYGVDALVPVLDLVADSGLGLPAGYVGSERGAS
                     LKMRTDRDELLLSLMQQVLLDGRDELRLTDDMVHALEKAAGTDERLFVPRVEAAFEIHA
                     PSTRALSSGTFDLLLTAVPRPGSSMAGRFAHVLPPEHQDALATSYRGAPDRLTAQLVFP
                     PRRHRNENVTRTPRLLPHIIELSGHQERDETTIRLADIAVTADPRSFHLVQLSTGRPID
                     VRVLHALEGGTQTPPLARFLAEVANGRYAAYKPFDFGAGSRLPYLPRVRYRRTILTQAR
                     WLLMAEDLPARKAPRKEWEDAFTAWRDRLRVPMQVAVIEYDQRLPLDLSHPVHLRVLRA
                     HLDNARRVELREVPDADAHGWIGRAHEIWLSLGRSESDTPYVPRPRSTKSPGAQRHLPG
                     GSDVLHAQLHAHPRRYNEILSHHLPHLLAAFGKEPPTWWFTRHRKMARPDSDQHLDLTL
                     LLSPDSYGVGTQHVRAWADSLHAMGLASGLALAPYQAQTGRFGHGPAMDAAHQVFAADS
                     AAALAQIQLAERTDAFAPQALASASALHLVTRLAPDTAAAEEWLVGNLPQGTGRLDRTL
                     RGQVLELTGPNGASALASLPRGPQVTEAWRTRADAVDAYRTALVGERDPLDVARSLLHQ
                     HHVRALGVDPRTEETTIRLVRTAAFQHRVADR"
     aSDomain        complement(14526..14801)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B053_RS0121015_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="2.40E-18"
                     /identifier="RREFam001.1"
                     /label="B053_RS0121015"
                     /locus_tag="B053_RS0121015"
                     /protein_end="248"
                     /protein_start="156"
                     /score="57.6"
                     /tool="antismash"
                     /translation="VANNAARTRGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAVMD
                     AARTPIAYGALYGHLRDSFPQATPEQIDALLTSLVEQRFLITSLWAP"
     misc_feature    complement(14820..14822)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15356..15547)
                     /locus_tag="B053_RS0121020"
     CDS             complement(15356..15547)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="B053_RS0121020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_012380187.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 8.6e-16, bitscore:
                     52.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPAPLAGLDDDFAPLDVKVVIAEHAYGKLMCSTGDGCG
                     TTCATGASACGSFTEDPA"
     gene            complement(15603..16838)
                     /gene="fxlM"
                     /locus_tag="B053_RS0121025"
     CDS             complement(15603..16838)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="B053_RS0121025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_018490583.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-36, bitscore: 121.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTVEPDEATRLRNKVVDELRAGGNISSSEIEAVMRKVPRHAF
                     IPDTPLDRAYDTYAAVITKTDEHGVQLSSVSAPQIQAMMLDQAQVKPGMRVLEIGSGGL
                     NAAYLAELVGEHGEVVTVDIDPVVTERAHRLLNEHGYDRVRVLTADAAEPIPELGEVDV
                     VMVTAGAWDIAPAWTAQLKQGGRLVVPLRMRGLTRSVAFTQIPGEHGPYLESVSALICG
                     FVPMQGSTAHREELLLVNGTPEIGLKFDDGLPADPHRLDNAVTFPRHELWTGVVVGLSE
                     LIDTLQMAMAISLPGFCTMAVDEDLDTGLVAPVNKRFALAAVEDDTFAYLVTRRTEDNK
                     HIEYGVHALGPNAKQFAGQVADVLRDWEASRRGGPSPVIRVYPVNTSDDQIPAGRVIDK
                     VHSRVSLSWPSA"
     misc_feature    16903..16918
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     gene            complement(17057..17476)
                     /locus_tag="B053_RS0121030"
     CDS             complement(17057..17476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380189.1"
                     /locus_tag="B053_RS0121030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_026237980.1"
                     /transl_table=11
                     /translation="MSTAVAPKPPAQEWTPPLDADGLRLVLERFRAWEPLDIEEVFDDL
                     DAAIGSQPPPVATAVALLGRLRRRLKQLSDITVADDSFPPSAEMTRLVERGVPLLEEPT
                     PAGYRQAVGLARRLAFVTADLIEVLIEARYIKEID"
     misc_feature    complement(17408..17410)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17473..17898)
                     /locus_tag="B053_RS0121035"
     CDS             complement(17473..17898)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380190.1"
                     /locus_tag="B053_RS0121035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_026237981.1"
                     /transl_table=11
                     /translation="MTVAQPNAIGSPGYAAEVPCVRESVSLARAFISQVLAVWDMDDDV
                     TGWGKIIVTELLANAVEHTETPVSRIHIERPSNGAVRIGVSDRSHDAPHLKTADLNAES
                     GRGLSLVAAMSARWGYDTHPWGKVTWAVVETPAGREQ"
     gene            18517..19389
                     /locus_tag="B053_RS0121040"
     CDS             18517..19389
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS0121040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_234018028.1"
                     /transl_table=11
                     /translation="MNQLVEADDRQGGHASLATAALEARAKVLELQQRNASERVRRALY
                     ALAAEFTTVAAWSCIDLRDLDKARTYLHESSTFAGLSQDPPTAMRVWVNMAMLAYQRKN
                     WPEQLAAAQAANASPAARKDPFFGSMGRVRLALAHSSLGDLRAARRSLGAAQENYRKAA
                     EDERPRWTAFYGPAELNHLAAIILNHNGEPAEAEAMAHRSLAKIPAEFQRNRALATCQL
                     ALAQLRQGEPEQATATAGTVFTIMEGAPLPGRMRTLIGDFHRDLFRLAPSTTYARDWAD
                     RMRDEWSRT"
     gene            19374..19913
                     /locus_tag="B053_RS0121045"
     CDS             19374..19913
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447161.1"
                     /locus_tag="B053_RS0121045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_026237983.1"
                     /transl_table=11
                     /translation="MEPNVTRVIDLRHYGQGSLPEGFKQMLIDVHADAYADAMDNEFNQ
                     RFPWFVDHWSGMDGFTCVVAFDGDEPTGFAYGAPLQPGREWWRSTAFAPNNGYTATYAV
                     SEVMVRPQWRGQGISERLHEALLKERGEDLAVLLVDVTHPKVQGLYETWGYEKAGEQRP
                     FADSPVYAVMVKRLYA"
     gene            complement(19931..20866)
                     /locus_tag="B053_RS01000000134360"
     CDS             complement(19931..20866)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154755.1"
                     /locus_tag="B053_RS01000000134360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_234018025.1"
                     /transl_table=11
                     /translation="MRHLRAFLAVAEEGNVTRAAAHLGLTQPAVSRTLAALERHLGLRL
                     VDRSTHHLALTPEGVAFRDKAAAAVAAFDEALDTGRLRHWPLRLGHAWSAFGPYTTPLL
                     RAWRERHPATPLELLRIDDRTAGLTRGEVDAALLRGPVHAPGLVTEVLFTEGRVAAVTA
                     DGPLASRTSLRLADLVDGPVVLNTVSGITTPELWPPDARPAATLTVANTDDWLAAIAAG
                     RGSGVSAASTAAIHPHPGVAYVPLDDAPGVPVLLAHRDGPGHPALPKLAALAREIVARG
                     RGPGAPGGPGTSPGASAGATRRPVHGTAVT"
     gene            21354..22325
                     /locus_tag="B053_RS0121055"
     CDS             21354..22325
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510823.1"
                     /locus_tag="B053_RS0121055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EamA family transporter"
                     /protein_id="WP_018490589.1"
                     /transl_table=11
                     /translation="MNVQRSAPEPAAAAAAVAVPEAAPALDAAGRKGSGPGRGAALVPV
                     ALVVAGGLSVQFGSAVAALLMPKAGALGVVTLRLAAAALILLVVCRPKVRGHSRADWGT
                     VLAFGVAMGGMNTLFYQALDRIPLGIAVTLEVLGPLALSVFASRRLVNVVWAGLALVGV
                     VLLGGGGFDRLDPVGAAYALGAGAMWAAYIVFSARTGRRFPQADGLALAMVVAAVLSLP
                     LGIWESGAKLTVPSTLALGAAVAVLSSVLPYTLELMALRRLPASTFAVMMSLEPAIAAA
                     AGFLILNQALSTTDALAIALVIGASMGAVRSQTGTRKRKKKA"
     gene            complement(22362..23084)
                     /locus_tag="B053_RS0121060"
     CDS             complement(22362..23084)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967200.1"
                     /locus_tag="B053_RS0121060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_026237984.1"
                     /transl_table=11
                     /translation="MTAEPHLVKPHFDGDRLVLEEHREADHVRYLFPGTATGPAGPLRA
                     LTLTEALHARIGPAGTAEAVLRAWAQRAGPAETVEVKVADPAAVPPVRVRAGAIVIRDG
                     HVLLIHFREPDEGGPHYEIPGGGVEAGETPEEAAVRELREETGLHGSVERKVARVWKEG
                     RHEHYFLLTAEGGIGPAETLDTYGGTPVWIPVPDLPALPLWPRRLSWRIEHWHRTGWPT
                     LPAELADSVTDLQAPCTW"
     gene            complement(23211..23645)
                     /locus_tag="B053_RS0121065"
     CDS             complement(23211..23645)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126646.1"
                     /locus_tag="B053_RS0121065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PIN domain-containing protein"
                     /protein_id="WP_018490591.1"
                     /transl_table=11
                     /translation="MIIVADTSALYAAFDAAQPEHSAAARILEHERLAISPLVVTELDH
                     LVHRDLGFPAALQVMEALNSRMDDGQYRLAELKLADLRTAHEVRQKYEGLRLDLADAVG
                     VVLADRYRTDRIFTLDQRDFRAMTPLTPGLDAFRIVPADH"
     gene            complement(23642..23884)
                     /locus_tag="B053_RS0121070"
     CDS             complement(23642..23884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154750.1"
                     /locus_tag="B053_RS0121070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CopG family transcriptional regulator"
                     /protein_id="WP_078507755.1"
                     /transl_table=11
                     /translation="MIKTTVYLPEDLEVRLDAEAAATGISKAELIRRGIALLLEHAERP
                     KRSCELPVFDSGRPRTPDEMDDSVYEHIKERAARR"
     gene            24093..24959
                     /locus_tag="B053_RS0121075"
     CDS             24093..24959
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061107.1"
                     /locus_tag="B053_RS0121075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR03084 family metal-binding protein"
                     /protein_id="WP_018490593.1"
                     /transl_table=11
                     /translation="MSDVAAVVDDLREESGELNALVGALDEEAWRGATPAEGWTVAHQI
                     AHLAWTDEVALLAATEPERFGDEVAKALAAPDAFVDEAAGALVAAHAPRALLARWREGR
                     RRLDTVLREAPAGTRIPWYGPPMSVASMATARLMETWAHGQDVADALGVTRTPTARLRH
                     VARIGVRARNYAYAVRGIEAPAEEFRVELRSPGGEMIAYGPERATQRVTGPLLDFCLLV
                     TQRAHRSDLAVTAEGSEADRWLSIAQAFAGPPGPGRPPRAEQAGKAEQASHADQAVRDE
                     QAARGDR"
ORIGIN
        1 ggctcgtgga cctctcgcca acgggcggct acccctcgtg gccgaacggg cagcccagct
       61 tcaccggcag ctcgtacagg tcgttctgcg tcacgatcgg cttgttgcgc agctcggacg
      121 ccgggaccgc cagctccagt tccgggaact tctcgtagag cgccgggagc gcgatgcccg
      181 cctccagccg ggacagggcc gcgccggggc agacgtgcgg gccgtggccg aaggcgatgt
      241 ggcggttggg ggtgcgggtg gcgtcgaact cgcccgccgt cgggccgtac tgccgctcgt
      301 cccggcccag cgcggcgaac gagacgatca gcgcctcgcc cttcggcagg acccggtcgc
      361 ccacctcgat gtcctccgtc gcgaagcgga tcaggacgtg cgaggtcggg gtgttccagc
      421 ggagcgtctc ctcgatcaca ccgtcccagc cgatctcgcc gttcaccacc ttcttgcgct
      481 gctccgggtg ggtctggagc gcctcgacga cgttgacgat caggctgatg gtggtctcat
      541 gtccggcggc gatgatcagt tgcagcgtgt tgacgatctc ctcgtcggtg aggtggtcac
      601 cgttctcgga ggccgcgatc agggcgctgg tgaggtcgtc gcccgggttc gcccgcttgt
      661 cgttcacgat cttcgtgaag agggtgccga ggtccgccat catctgcggg acctcctccg
      721 gaggggtctg cgtcgagaag aacttctcga acagctcctt cagccgcgga tggtccgccg
      781 cgtccacgcc catcagttcg ctgatgacgt tcatggggag cgggtacgcg aacgccgcct
      841 tcaggtcgac cggttccccg gccgggtggg cggccagctt ctccaggctc gcgttcgtca
      901 gcgcctcgat gccctcccgc agccgctcca cccggcgtac ggtgagcgcc tgcgccacca
      961 gcgtacggag ccggcggtgg tcggccccgt cgaccgtgag catcgagcgg cccgggttgg
     1021 ccaggccgat cagcggccag tccatgggta tctcgccgcg ccgccaggcg ttccagacgt
     1081 cgatgtcctt gaccacccgg ctgtcggtga gcagcgcccg ggcctccgcg tggtgggtga
     1141 ccgcgtacac gtgtacaccg cccggcagct ccacctccgc cagcggcccg gcggcccgca
     1201 gcgcggcgct ctcgccgtcg aggtcgctga cgaacgggtc gagcgcgatg cgggtcatgc
     1261 ggggcctccg tggcttccgg gtctgccgag ggcgggcgtg ggcgtgaaga gcacgggcag
     1321 gtcggtgagg ccgcgcagcc acggcgacgg gcggcgggtg agctgctcgg cggggatggc
     1381 gaggtccacg tccggcagcc ggtcgagcag cacctcgatg ccggtacggg cgatgacctc
     1441 ggaggtctcc tgggccggga acgggcagcg gtgctcgccg tggccgaagg agaggaacgc
     1501 gttgttgccg ccggtcagcg ccgaggcgtg ggtccgcacc tgagggtcgc cgttggcggc
     1561 ggcgatcccg agcagcagca gatcaccggc gcggacgtgg cgcccgccga ggtgggtgtc
     1621 gcgggaggcc cagcggcccg ccacgttctg ggtcggggtg tcctcccaga gcacctcgtt
     1681 catggcctcc gcgacgctgt gccggccgcc cgagagcgag gcggcgaacc gctcgtcggt
     1741 gagcatcagg cgcagcgagt tgcccatcca gtcggcggtc ggctggtggc cggccgccat
     1801 catcaccatg aggtcctggg cgacctcctc gtcggtgaac ccgcccgtgt ccgcgagcat
     1861 ccggctggcg acgtcgtcac cgggctcggc gtgcttgtcg gccagcagcc ggaacatcga
     1921 ggtggccagg tgctgctgtc cggccagcgc ccgctcgcgg ccgtcgatca tgtcgttgat
     1981 cgcgccgacc agcgggtacg cctcctcgtc ggagaagccg tagatcctgg ccaggacgag
     2041 cgccgggagc agcttggcgt actccgcgat gatgtcgacc gcgcccttgg tgcagaaccg
     2101 gtcgatcagc ccgtccgcga actcctccgc gtaccgcttc agggagaacg ggtcgacgcc
     2161 ctccagcgcg ttgctgatca tcatggcccg gacgctgtgg cgctccccga ccgtgtagag
     2221 gatcgagttc tgcccgcgcc cgatcatcgg cagcagcggc cagtcggcgg ggatgcggtc
     2281 ccactggttc cacagctcgg agtcgcggct gaagaggacc gggtcgccgg tgacctggtg
     2341 cagctcgcgg tagccgagga cgagccaggc gggcacgccg ccgtcgagca cgaccggggc
     2401 gacggcgccg tggtcgcgcc gcatgtcccg gtagagctgg acggggtcgc tctggaagcg
     2461 ggggccggag agcgggacgg agcggtgggc gacggggcag ccggagggca tggctccgga
     2521 aggggtggtc ccgggggccg tggcggacgc ggtggccccg gagtccgtcg ttccggtggt
     2581 ggcggtccgc ccggtggcgg ccgtcaggcc ggaggccgcg gtgccggagt ccgtcgccgg
     2641 gccggagtcc gtcgggccgg aagcggtcgg tccggtggtg tcggaggtgg tcgtcacggg
     2701 gcgggctccg gggtcgggcc ggccagggct gccgcgggca cggcggaccc gggcacggcg
     2761 gctcccggcg cgtcggctcc gggggcgcgc agccgggcgg cggagagcgc ggcgaggtgc
     2821 tcgacgagcg tgatgagcac gtacttgctg gaggaccggt cgcgcgcgtc gcactccacc
     2881 agcggcacgt cgtccgcgag gtccagggcc tcccggatct gctgctcgct gtggagcggc
     2941 ccgccgaagt cgttgcacgc cacgatgaac ggcgtgccgt ggtgctccag gcggtcgatg
     3001 gcgtaccagg agtcggccag ccggcgggtg tcgacgagga cgaccgcgcc gagcgtgccg
     3061 gagaagagcc ggtcccacag gaaccagaac cgctcctggc cgggcgcgcc gaagaggtac
     3121 agcaccgagc gggcgtcgag cgtgatgcgg ccgaagtcga acgccacggt ggtggacgtc
     3181 ttggcctgga cgccgtcgag gtggtcgacg gcctcccccg cgcgggtcat cgtctcctcc
     3241 gtgttgagcg gacggatctc gctcacggat cggaccatgg tggtcttgcc gacgccgaag
     3301 ccgccgacga caacgatctt gagtccgttg tcggcggtgt cgctcagggt ggcgcggtca
     3361 gaggttgcgg agtccaacga gcacctgttc caggatgtcg gggtcgggga gccggtccgc
     3421 gacacgggcg gtacgggggt ggcgggcgct gacccggccg gtgtccagca ggtcgcacag
     3481 catgatgcgg acgatgctga ccggcaggtt cagggtcgcg gagatctcga cgacggcggt
     3541 cgggctctgg cacatccgca ggatcgccac atgctccgac tgcataccgg gggccgggtc
     3601 gcactccgcg acgacgaggg tcaccagatc gaaggcggcc gagtcggagc ggctgcgtcc
     3661 cccggtgagg gtgtacagcc ggtccggatc gtcgtcgcgg cccgggcgcg ggcggggcgc
     3721 cgtcgtcata cggccgaact ctctgccacg ggggtgcgcg gcggggcgac gaggtgctca
     3781 ccgagctgtt cgaccagctc gctcatgttg tggccgacca ggcccacgtc ggagtcctcg
     3841 tcggcgacga ccgcgaggtg ggcgcccgcg cccgcctcga cgatgaacag caccccgccg
     3901 tagaactcgg ccatcgcgga gcgtacgccg ccgctgccgt caccgaactc gatggacgcg
     3961 ccgtgcgaga ggctctggat cccggcggag atcgcggcca gctggtcggc ctggtcgacc
     4021 gagagttcgg gggtgcggca cagcttgagg ccgtcgcggg acaggacgag ggcgtggcgg
     4081 gttccggggg tgcggtcgag cagcccctcc agcagccagt tgagcttctc gtcggtggtc
     4141 gcggtcatcg ggtgttgcct tccgggtgcg gggagttggc acggaccgcc cggctgaagg
     4201 tgctgaagcg cgcagcctgg accttcgcgt cggtggtacg ggcctggggg gtgtcggctc
     4261 cgccgtgggc ggcgttgccg ttacgggctt cggcggcggc cagcgtgcgg ccccggcggc
     4321 gcttgggcag gccgctctcg ccgaacgcgg ggacgccgcc ggtggattcg gactccgact
     4381 ccgtgcgccg cggctccgcc gccggggtca ggggcgtgga gccgtcggat gcctggttct
     4441 cggcggtgga ccgggccgcg ggcacggtcc cggagcggcc cgcgccctcg gccgacgcgt
     4501 gggacggctc gggctcggcg ggcgcggctg tgggcgcggg tgcggccgaa ggcgtggcgg
     4561 ccgggagcgc ggcgggggcg gtcgcggcgg cggggggcgt ggccggtgcc cggtccggga
     4621 gggcggccgg tgcggcggtc cgggagatca ggtcctgggg cagcatcatc agcgcgccgg
     4681 tgccgccccg cgcggagggc cggaaggaga cggtcaggcc gtgcttacgg gccagccggc
     4741 cgacgacggc cagtccgagc cgggtgccgg agaggttggt gaggttctgg tggtcggcgg
     4801 agacggcctg ctcggcgcgg cgcagctgca cctcgctcat cacgagcccg ctgtcctcga
     4861 cggtgatgac gatgcccgcc gggacctcct ccacgtacac gtgcacctcg gcggtgggcg
     4921 gcgagaagtt ggccgcgttg tcgaggagtt cggccagcgc gtgcatgacg ccctcggccg
     4981 cgtgcccggc gatcgccaca tcgctggtgg agtggaggcg gacccgctgg taggagccga
     5041 tacggcccat cgcgccgcgc aggatcgact ccatgacgat cggcttggcc cagcgccgcc
     5101 cggagcgcgc cccggtcagt acggcgatgg agtccgcgag ccggcccgcc tgggcggtgc
     5161 ggtggtccag gtggagcagg tccccgagga cggactcgtc ggtgtgccgg tgctccatct
     5221 cccgcaggtc ggccagcatg ctggtggcca gggcctgcat ccgcccggcc gcgttggcgc
     5281 aggccgcgac ggcggcggag cgctcggtct cggcgcgggt ggcccgggcg gtgagccggt
     5341 ccacggtgac ggagagccgg gccttctcgg cggcggcctc ggcggcggtc cgctcgttct
     5401 cggcgcgggc ctcggcggtc acccgggcgg tctcggcgga ggcggcggcc ttgatccggg
     5461 ccgtctccgc ggtgaaacgc tgggcctcgg cggcggaggc ggagaccagc cgcgaggtct
     5521 cggcggtgaa ccgctggttg tcggcggccc gctgggcgcg cagggcgcgg acggtcccca
     5581 gggtgtggac ggtgacggcc acgcagatgc tcagcaggac ggcggccccg gccgcgcccc
     5641 aggccagcgg ggtccgtacc gcatcggggg ccgcgaccac ggcccacagg gtcagcgcgc
     5701 cggtgacggc tgccgagatc agcagggcga gtgcggtggg cctgaatgag gggcgcaatc
     5761 ggagtcctcg gtggcggacg gtgcgggacg tgggacgagg cgaaaccgca ccggtgaaat
     5821 ccggacagtt caccacggga gtggacgatc atgcacaact ggagctgata gttcctgctc
     5881 aagtcttggt cactatagga gacttgacgg tctgtttggg aagatcttgt gggctttttt
     5941 gtgaagcttg agcaattttg tccgcccaca tcccaagagt tcatctgtac cgacggcatg
     6001 ctgaggccat ggccgaactc catcgcccgc ataccggacc gtcggcaccg ccggccggct
     6061 tcgtcgccgc actccgcgcc gccgtgcgcg gcgagaccgg cttcggcccg accgcccggg
     6121 ccctgacgac gatggacgcc tccaactacc gccgcgtccc cctcggcgtc ctcgccccgc
     6181 gcgacgccga cgacatcgcg gcggcgctga cggtctgccg ggagtacggg gtccccgtcg
     6241 tcccgcgcgg cggcggcacc tccatcgcgg gccaggccac cggcaccggc ctggtgctcg
     6301 acctcacccg ccacctgaac gcgatcctcg gcctggaccc ggccgcccgc accgccaccg
     6361 tccagcccgg cgtggtcctg gacgacctcc gggccgccgc cgccccgcac ggcctgacct
     6421 tcggccccga cccgtccacc cacagccgct gcaccctcgg cggcatgatc ggcaacaact
     6481 cctgcggagc gcactcggtg gcctggggca ccacggcgga caacgtgacg gcgctggagg
     6541 tggtccggta cgggggcgag gcgctgcggc tggaacggac ccggggcacg ggacccgacg
     6601 gcacacgcgg cacctcgccc caggggcccg acggcacacg cggcacctcg tcccacggcc
     6661 cccacggtgt aagcgaactg atcggcgccc acctcgctct cctccgcacc ggctaccccc
     6721 gcctcccgcg ccgcatctcc ggctacgcgc tcgacgccct gctccccgag caccccggcg
     6781 gccccgaccc ggtccgggcg ttctgcggca gcgagggcac cctcgccgtg gtcaccgagg
     6841 cgaccgtgcg cctggtcgag accccgcgcg cccgagccct ggccgtcctc gggtacgccg
     6901 acgaggcggc cgccgccgaa gccgtcccgg gcctcctccc gtacggcccg ctcaccgtcg
     6961 agggcatggc cgcggacctc gtacggaaac cggccgggct gccgcgcggg gccgcctggc
     7021 tcttcgtcga gacgggcggt gccaccccgg ccgaggcgcg ggcgcacgcc gagcgcgtcc
     7081 tgcgctccgc cgacgcggtg gacggggccg tcgtcaccga cccggccggg cagcgggccc
     7141 tgtggcgcat ccgcgaggac gccgccggga ccgcgacgcg gatgcccgac ggcacagagg
     7201 cctggcccgg ctgggaggac tgcgcggtcc cgcccgaccg gctcggcccc tacctccgcg
     7261 acttccgggc cctgctcgcc gggcacgccc tgcgcggcac gccgtacggc cacttcggcg
     7321 agggctgcat ccacgtacgc atcgacttcg acctcctcac cccgtccggc atcgcccgat
     7381 tccgcggctt ctccgaggag ttggccgatc tcgtcgtcgc gcacggaggc tccctcagcg
     7441 gcgagcacgg cgacggccag gcccgggcgg agctgctgcc ccggatgtac ggggacgaac
     7501 tcgtgggcgt cttcggcgcg ttcaaggacc tgtgggaccc ggacggcggc ctgaaccccg
     7561 gcatcctcac ccgcccggcc ccgctggacg ccaacctccg cttcgcggtc ctcccgaagc
     7621 gcccggtgga cgtggccttc ggctatccgc aggacggcgg cgacttcgcg ggcgcggtac
     7681 ggcgctgcgt cggcgtcgcc aagtgccgta cgacggaggc tcctggtggg ggcgcggggg
     7741 tgatgtgccc ctccttccgg gcgaccggcg aggaggcgca ctccacgcgg ggaagggccc
     7801 ggctgctgca cgagatgctc gcgggcgagg tgatcacgga cggctggcgg agcacggagg
     7861 tacgggacgc gctcgacctc tgcctctcct gcaaggggtg ccggagcgac tgcccggtgg
     7921 gtgtcgacat ggccacgtac aaggcggagt tcctgcacca ccactaccgg ggccggatcc
     7981 gccccgccgc ccactacgcc ctgggccgcc tcccgcagtg gctgcgcctg gccgccccct
     8041 tcgcccgccc gctcaacgcc ctggcgcgcg taaggccgtt ggccgcgctc gcgaagcggc
     8101 tggcggggat cgcacccgag cgcacgatcc cggtgctggc gacggagacg tacagccgct
     8161 ggctgcgcgg acatcagagc gaggggcagg gcgagaggaa gggcaggggg ctgagcaacg
     8221 ggcagagcga agggctgagc aaggggctga gcaacgggca gagcaggggg cagggcgaga
     8281 ggcggaacga cggggagggc gggcggcagg acggtgaggg aacgcgcgtc cctttccccg
     8341 gcggggtggt ccacctctgg gcggacacct tcaccgagtt tctgtccccg caggtggggc
     8401 gagcggccgt acgggtcctg gaggaggcga cgggccgcac ggtcctgccg ccaccggacg
     8461 gggtctgctg cgggctcacg tacgtgtcga ccggccagct ggacgcggcc cgccgggtga
     8521 tgcgccgcac cctggaccgg ctcgccccgc tccccggcga cccggtggtc gtcctcgaac
     8581 cgagctgcgc cgccgccctc cgtaccgatc tgcccgaact cctccccgac gacccgagag
     8641 ccgccgaact ggccgcgcgc gtgcgtacct tggcccagta cctggaggag cacgcccccg
     8701 actgggcccc gccccgcctg gaccgcccgg tcgtcggcca gacccactgc caccagcacg
     8761 cggtcctcgg ggacgcggcg gagcggcggc tgcgggagcg gatggggctg accggcgaac
     8821 tcagcggcgg atgctgcggt ctggccggga acttcggctt cgagaagggg cactgggagg
     8881 tgtccgttgc atgtgctgag gagcaacttc tcccttccgt aagggagtcg gagccgggcg
     8941 cggagctgct ggcggacggc ttctcctgcc gtacgcaact ggaccggctc ggcccgccgg
     9001 ccggacgccg ggcccgccac ctggccgagg tgatcgcgga agcactggag gacggtgccg
     9061 gcgaacggcg atcacggcgg tgagcgcggg gcgcttgtac ggtgacgcgc gtgaagactc
     9121 aagtgatcgt gctcaacggt ggttccagct ccggcaagtc cggtatcgcc cggtgcctcc
     9181 aggccctcct gccggacccg tggctcacgc tcggcaccga cacgatggtc gaggcgatgc
     9241 ccgccgccct ccaggccgcg gagacgggga tcgtgttcgg cccggacggc tcggtgagca
     9301 tcgggtcgga gttctgggag ctggaggacg cctggaccga gggggtcgcc gcgatggccc
     9361 gcgccggcgc ccggatcatc gtcgacgagg tgttcctcag cggggcggcg ggccggcgcc
     9421 ggtggagcga acggctggac gggctggggg tgttgtgggt cggcgtccgg tgcgcgggcg
     9481 aggtcgcggc ggggcgggag atcgcccggg gcgaccggac cgtcggcatg gcggcggcac
     9541 aggcggagag cgtccaccgg ggtgtggtct acgacctgga ggtcgacacc acccgtaccg
     9601 aatccctgga ctgcgcccgg acgatcgccg cccacgtcaa gggggaggag gccgggcgct
     9661 agcatcgacg ggtttgcagt gatcgccgcg gttcgcaagg gggaacgtca tggaggacgg
     9721 tggaaagctg cggcggaggt ggacggtcct tgccgcggcc ctgtccggag cggtgctcat
     9781 atccggcatc gggctctggg cgacggcggt ctcgccccga ggtgtgaccg caaggtccgc
     9841 tccgctctca ccgacacggt ggtgatggcc ctctcccgac acccgaggtc acccacaggt
     9901 ccctggcgga ctacctgcgt ctgacgacca tggcgtagga gaacgctgtt tcagcgaccc
     9961 cggatggtgg tgacgacgag ggtcgtgaca ggccatgtcc ctaccaaggg gactcgtcct
    10021 gcagaactgc ccctctggcc gcccgggcca ggatgctttg cccgcgcagg gacagcccaa
    10081 gtcgattcca gtggaagatc acgtggtagc tgagcacctg tcgtagccct cggtcgagcg
    10141 ttccgtcctg gacgccgttg gcgagtgcct ggccggcgct gtggaatgct gcgacccact
    10201 cgacgacggg ttccagcggt cctccggggc gcagcagggt gtcgctgttg gcgagaagca
    10261 ggggccggat ctccagggct cgggcgttga gctgttccgg cggaacgtca ctgacggccg
    10321 agcggtgctc cgtcgtgatg atgcggtccc agacatcgcc ctgctcatac cactccaacc
    10381 gtgcggcgcg catcatgatg gtgcacagca ggacggacaa ctccctcggt ccgatggcga
    10441 gatcgtcgcg caggcgcagc tgctggatct ttcggctatc ggtgacgaac agggcgtgcg
    10501 cggccgtcat gctggtcttt ccgccgaacg ccagcgtctc cggttcatag ataccgggcc
    10561 accagcgctg aaggtgtcct tcggatacga ggcggtcgaa gccatcctcg atggtccgct
    10621 tggcaccgtt cacgggctgg atccggagac gcagccgcca gcaggggtgc tttctggtgt
    10681 accaccagcc gtcgatcgcg tcggcggctt ccgcctcgcg caggatgggc aggacacgcg
    10741 tggcgaaagt gctgtcggcg ttcgaccagt ccgtgaagtg aaggtacgtc tgccaccagt
    10801 cggtggtggc cgcttggcgg accagggctt cccggccggc ctggttgtag accgcgactg
    10861 cgtcggagag gaccacgggg tccattcggt actggcgcgc tgcgtcgcgg agtggcaggc
    10921 cggtcaggac ggcgaggacg gcgtgctgcg tcgggctcgg ctcacttgcc tgagtcagtt
    10981 gatcaagaga catgcgtccc atccagtgct cggtgcctgc tttgaggcga acgtggtgag
    11041 ggcgagtgcg gtgccggccg cgccgttgat caggccggga gtcgaggagg tgccgggctg
    11101 gccggggatg gtgagggcgt taccgagacg gcccgggagg atgcgcaggc gtgcgtcgag
    11161 cgcgtctgcg gctgcgcggt gagcggtctg gtagatgccc gcccatccat ggcagagacc
    11221 gctgtcggtg accagggcga gttgcgcggg atcggacaag gcccggtaca gggcatcctc
    11281 gtagaacttc tggagcgtgg gcgagcgcag ggcgatcccc gcgagctgcc ctgcccgtgc
    11341 gatgcctgtc atgccgtagc accagctcgg acgggcgggg gcgtcgtgat gtggctgact
    11401 gcggtcgagg tcgcgccggg agatgtgctc tggccaccac gggccggaat cgccgtgctg
    11461 gcaccaggcg tcgaggtggg cgcagatggc gaacatggcg tcctggtggc catggacggt
    11521 gacgcctcgg cgcatggcct gggccaggag gaggagcggg cctgtgatgc cgtgggccgc
    11581 gccgaagttg ccgtgcccac ccgggaagtg gggcgactcg ccgcgcgccg ggtcatggcg
    11641 gacccaccag ccgggcagcc cgcgcccgtc agagccgagc ggccgggtca ggccgacgag
    11701 gtactgcaag atcctttcca gggccgggcc ctcgggctcg gtgcgcagga agtaggcgcc
    11761 gatcccggtg aggccgtaga agaggtcgta ctccgcgaag gtcggcaggt ctcccctgcc
    11821 gatgcgggcg agcgcggcgt ccacgcggcg gttggcgagg tcggtgatgt gctggtgcaa
    11881 ggtcgtgcgc gccgaggcgt acagatgctg gtaggccgga ggaacggcgg tgaggacgaa
    11941 gccgactgcc ggggcgccga ggaacaggcc cgtctggtcg gccgcgctga tggctccgga
    12001 ggctgcactc gtgatccacc ggtgcgcgga acgccaggag ccgccgtacc tgctggcgat
    12061 ctcgatgtgc agcaggctga ttccggcagc accggcggcg agcgactgga ccgcccaggg
    12121 ctcctccggg ggcgggagag gaggctcagc cagatcagct gtgtactgct ccagaattgt
    12181 tgcggcggtg gttgccagcg tggtcatcgg tccgccaccc ggtgctggaa ggcggctgtt
    12241 cgcacgagtc gaatcgtcgt ctcctcggtg cgcggatcga cgccgagagc tcggacgtgg
    12301 tgctggtgca gtagcgaccg ggcgacgtcg agcggatcac gctcaccgac caatgccgtc
    12361 cggtaggcgt ccacggcgtc ggcgcgggtt cgccacgctt cggtgacctg cgggcctctg
    12421 ggaagggacg cgagtgcaga ggcaccgttc ggcccggtga gttcgagcac ctggccgcgc
    12481 agggtccggt ccaaccgtcc tgtgccttga gggaggttgc ccaccagcca ctcttcggcc
    12541 gccgcagtgt ccggtgccag gcgagtgacg aggtgcaggg cgctggcgga tgcgagggct
    12601 tgcggcgcga aggcatcggt gcgctcggcg agctggatct gtgcaagggc ggcggcagag
    12661 tctgcggcga acacctggtg cgcggcgtcc atggccggcc cgtggccgaa gcgtccggtc
    12721 tgcgcctggt acggggccag ggcgagtccg gacgcgagcc ccatcgcgtg caggctgtcg
    12781 gcccacgcac ggacgtgctg tgtgccgact ccgtacgagt ccggcgacag gagcagggtg
    12841 aggtcgaggt gctggtcgga gtccggccgg gccatctttc ggtgtcgggt gaaccaccag
    12901 gtcggcggct ccttcccgaa cgcggcgagt aggtggggga ggtggtggct caggatctcg
    12961 ttgtagcggc gcggatgggc gtggagctgt gcgtgaagaa cgtcgctgcc acctggcaga
    13021 tgccgctggg cgcccggcga cttagtggag cgcggccggg gcacgtacgg ggtgtccgac
    13081 tcggaacggc ccagcgagag ccagatctcg tgtgcccgtc cgatccagcc gtgggcgtct
    13141 gcgtccggta cctcgcgcag ttccacgcgc cgggcgttgt cgaggtgggc gcgcaggacc
    13201 cggaggtgga ccgggtggga caggtcgagc gggaggcgct ggtcgtactc gatgacggcg
    13261 acctgcatcg ggacccgtag ccggtcccgc caggcagtga aggcgtcctc ccactccttc
    13321 ctcggggctt tccgggcggg caggtcttcc gccatcagca gccatcgggc ctgcgtgagg
    13381 atggtgcggc ggtagcggac ccgggggagg tacgggagcc gagaaccggc gccgaagtcg
    13441 aacggcttgt aggcggcgta ccgtccgttg gccacctctg ccaggaaccg ggccagcggc
    13501 ggggtctggg ttccgccttc caaggcgtgc aggacccgca cgtcgatggg ccgaccggtg
    13561 gagagctgca cgagatggaa actgcgtggg tcggcggtta cggcgatgtc ggcgagcctg
    13621 atcgtcgtct cgtcgcgctc ctggtggccg gacagctcga tgatgtgcgg aagcagtcgc
    13681 ggagtgcggg tgacgttctc gttgcggtgc cgacgtggcg ggaacacgag ctgtgcggtg
    13741 aggcggtccg gtgccccgcg atagctggtg gcgagggcgt cttggtgctc gggcggcagg
    13801 acgtgggcga accggcccgc catgctgctg ccggggcggg gcaccgccgt gagtaggagg
    13861 tcgaacgtgc cgctggacag cgcccgggtg ctgggggcgt ggatctcgaa ggcggcctcc
    13921 actcggggca cgaacagccg ctcgtccgtt ccggcggcct tctccagggc gtggaccatg
    13981 tcgtctgtca gccgtagttc gtcgcggccg tcgaggagga cttgctgcat cagcgagagc
    14041 agcagctcgt cgcggtcggt gcgcatcttc agggaggctc cgcgttcgga gccgacgtat
    14101 ccggctggca gcccgaggcc gctgtcggca accaggtcca gcaccggcac cagggcgtcg
    14161 acgccgtacc gggcccggaa ccggcgatgg tagtcgcgcc agtgctgata gccgtagggc
    14221 tgcgcggtgg tccggtagag ggctgacacg gctgcctgcg cttccgcgat cacggcatgc
    14281 gggagctggg tctcgcagtc gagggcggtg tcaatgagca acggtgtcgg ggtgacggcg
    14341 gtgagggcgc gcatccgcgt ggcgagggcg ctcacgctga tgtcggagag catcggctgg
    14401 tgggcggata gctcatcgcg gagtgcgtac agctcgtgga ctaggtcccg cacgccgggg
    14461 atgctgtccg cgtcgcgctg ttccagttcg tggcacaggt gctggagggg gtccaccgtg
    14521 gtcatgggcg cccacaggct ggtgatgagg aaccgctgct cgaccaggct ggtgagaagc
    14581 gcgtcgatct gctccggtgt ggcctgcggg aagctgtcgc gcaggtggcc gtacaaggcg
    14641 ccgtaggcga taggagtgcg ggcggcgtcc atgacggcgg ccaccggccg ggcattgcgg
    14701 acggatatct cgaccggggc cagcaggacg gcgtgcccgt cggagggtgg gcccggcgcc
    14761 acgagccgat cgccccgcgt gcgggcggcg ttgttggcga cgagcgggag ccgcgccagt
    14821 aacgcgggga tgcgctggag ccggaggacc atatcggtga cccattcgga gtccggccgg
    14881 atcagcacgc ggtgcttgtc gcgccaccgc gcgcttgccc tgggcccgac cgtcaccgga
    14941 gcggtgccag cgaacaggcc cagcggggtc ggccggtgtt gccaccgcaa gaggtaggag
    15001 accgtcgata ccgcggtgcg gcggacgtga cggggctcgg actgccggcc ttggacgact
    15061 gcttcgatgg cgtcggacag gacgggggtg gccagctcca gcgcgttgcg gaagccatcg
    15121 cattcccaga cgcggttcag ccactcgcga gtgacggcca cgctgtccag gtcgagggta
    15181 cgggggatgt ctgctggccc agtgctggtg gtggcgcgca gcatggcggc gccctgccat
    15241 cggtagtcgg cgactgctcg ggtaaccatg gggccctccg tctggcgggg cgggtgagga
    15301 gccggtgggc cgagcggagc gattcgctcg gcccatcggc agggaacggc ctggatcagg
    15361 ccgggtcctc cgtgaaggag ccgcaggcgg aggcgccggt cgcgcaggtg gtgccgcagc
    15421 cgtcgcccgt ggagcacatg agcttgccgt acgcgtgctc ggcgatgacg accttcacgt
    15481 ccaggggtgc gaagtcgtcg tccaggcccg ccagcggggc gggaggggcc agagtggcgc
    15541 tcgtcatgtt cttgcctttc ttcttggtgt ccggatggtg tggaacaacc tggcttccgg
    15601 cgttacgccg agggccagga gagcgagacc cggctgtgca ccttgtcgat gactcggccg
    15661 gccgggatct ggtcatcaga ggtgttgacc ggatagaccc ggatgaccgg gctggggccc
    15721 ccgcgccggc tggcctccca gtcgcgaagc acgtcggcga cctggccggc gaactgcttt
    15781 gcgttcgggc cgagggcgtg cacgccgtat tcgatgtgct tgttgtcttc ggtgcggcgg
    15841 gtgaccaggt aggcgaaggt gtcgtcctcg acggcggcga gggcgaaccg cttgttcacg
    15901 ggggcgacca ggcccgtgtc caggtcctcg tcgacggcca tcgtgcagaa gccgggcagg
    15961 ctgatggcca tggccatttg gagtgtgtcg atgagttccg aaaggccgac gacgacgcct
    16021 gtccacagct cgtggcgcgg gaacgtgacc gcgttgtcca gtcggtgtgg gtcggccggt
    16081 agtccgtcgt cgaacttcag cccgatctcc ggtgtgccgt tgacgagaag aagttcttcc
    16141 cggtgggctg tcgagccctg catcgggacg aaaccgcaga tgagcgccga cacgctctcc
    16201 aggtagggac cgtgttcgcc cgggatctgg gtgaaggcga ccgaccgggt caggccacgc
    16261 atccgcagcg gcaccacaag ccgaccgccc tgcttgagct gcgcggtcca tgccggagcg
    16321 atgtcccagg ctccggcggt caccatgacg acgtcgacct cgccgagctc cggaatgggc
    16381 tcggcggcgt cggcggtaag gacgcgtacc cggtcgtagc cgtgctcgtt caggagccgg
    16441 tgcgcccgct cggtgactac gggatcgatg tccacggtga cgacctcgcc gtgctcgccc
    16501 acgagctcgg cgaggtaggc ggcgttcagc ccgcccgaac cgatctccaa cacgcgcatg
    16561 ccgggcttca cttgggcctg atccagcatc atcgcctgga tctgcggggc ggagacggag
    16621 ctgagctgca caccgtgctc gtccgtcttg gtgatcaccg ccgcgtacgt gtcgtacgcc
    16681 ctgtccagcg gggtgtcggg aatgaacgcg tgccgaggca ccttgcgcat cacggcttcg
    16741 atctccgagg aggagatgtt gccgcctgcg cgcaactcgt ccaccacctt gttccggaga
    16801 cgggtcgctt cgtcgggctc gacggtcgtg ttcgtcatgg acttccttca gtcgtacgta
    16861 ttgggggatg caggccggcg tcgcgtgccg gatgggccgg ggaagccggt ggcgaacgcg
    16921 ctcggttctc gtcggctgac cgacggggtc gcgctggacg gcgcgctggg aggaccacgc
    16981 tcccggaggg ctgcccggcg ggccggttcg tgtcgaccag gccgctgggt ggctcgcggg
    17041 tggcaagggg cgtgcgtcaa tcgatctcct tgatgtagcg agcctcgatc aacacttcga
    17101 tcaggtcagc ggtcacgaag gcgagacggc gggcgagtcc gacggcctgc cgataaccag
    17161 ccggagtggg ctcctccaac agaggaactc ctcgctcgac aaggcgggtc atctcagcac
    17221 tgggcgggaa gctgtcgtca gccaccgtga tgtcgctgag ctgcttaagg cgtctgcgga
    17281 ggcggccgag cagggcgaca gccgttgcaa caggtggcgg ctgactgccg atcgccgcgt
    17341 cgaggtcgtc gaagacctcc tcgatgtcga ggggttccca cgcccggaac cgctccagca
    17401 cgagccgtaa accgtccgcg tcgagcggtg gcgtccactc ctgggctgga ggtttcggag
    17461 ccactgccgt gctcactgct ccctccccgc cggcgtctcg accacagccc aggtgacctt
    17521 gccccacggg tgcgtgtcgt agccccaccg ggcgctcatc gccgcgacca gactcagacc
    17581 ccggccgctc tcagcgttca ggtcggccgt tttcagatgg ggagcgtcgt gcgagcggtc
    17641 ggagactccg atgcggacgg caccgttgct cggtcgctcg atgtggattc gcgacaccgg
    17701 ggtctcggtg tgctcgacgg cgttggccag cagttcagtg acgatgatct ttccccagcc
    17761 ggtcacgtcg tcgtccatgt cccagaccgc cagcacctgg gagatgaaag cgcgggcgag
    17821 gctcacggac tcacgtacgc agggcacctc tgctgcgtaa cccggggagc cgatcgcatt
    17881 cggttgagcg acggtcatgg tcacgaggtc tttccctccg gctgggtttc ccggtccgga
    17941 caagcaaggc aggaccgggc tttcctccgt gccgccgcac cgaaccggct tggcgaccga
    18001 tgaccagtca acgagcgacg agcccagcgc aacaggaaga gtcccggatc cgtacacgtc
    18061 caccaaccgg aagactttac gtttcccttg cccaagctct aggtgtcagc gtgacggtgg
    18121 agctacgttc ggcgcatggg aggaaatctc gttcttcagg accgacttga tcaactcggt
    18181 ctgacgcagg aggagttggc ggcacgcctg aacgccgcgc tacaggagat caccggtcgg
    18241 cctggcggca tctcctcccg gacggtgcgc aacctgctca acggatcaag ccgacgccca
    18301 atcggacgca cttgcgctgc acttgagcgt gtgttcggct gccccgtggc ggacttaggg
    18361 ttcagcgcac ccagctccat gcaacatccc ccggagggcc ccgtgcggcg tcgcgacttc
    18421 atcgcttcca ctaccgggac ggcagccgca gtcgttcccg tggtcaagca acgtcggtcg
    18481 gtgggcatgt cggacgtggc ccgagcatcg gccggcatga accagctcgt ggaggccgac
    18541 gaccgtcaag gcgggcacgc ctccctggcg accgcggccc tcgaagctcg cgcaaaggtg
    18601 ctggagcttc agcagcggaa cgccagcgaa cgtgtacgcc gtgccttgta cgcgctcgcg
    18661 gccgagttca ccaccgtcgc cgcctggtcg tgcatcgacc tacgtgacct ggacaaggcc
    18721 cggacgtacc tgcacgagtc gtccacgttc gccggcctct cccaggaccc gcccacggct
    18781 atgcgcgtgt gggtcaacat ggccatgctc gcctaccagc gaaagaactg gccggaacag
    18841 cttgcggcag ctcaggcggc caacgcctcc ccagccgccc gcaaggaccc gttcttcggc
    18901 tccatgggcc gcgtccgtct cgcgctcgcc cactcgtcgc tgggagacct gcgggccgct
    18961 cgccggtctc tgggggcagc gcaggagaac taccggaagg cggccgagga cgagcgtcct
    19021 cggtggacag cgttctacgg gccggcggaa ctcaaccacc tcgcggcgat catcctcaac
    19081 cacaacgggg agcccgccga agccgaggcg atggctcacc gatccctggc caagatcccg
    19141 gcggagttcc agcgcaaccg cgcgctggcc acctgccagc tcgccctggc gcaactccgc
    19201 cagggcgagc ccgagcaggc tacggcgacc gcgggcaccg tcttcacgat catggagggc
    19261 gctccactgc cggggcgcat gcgcaccctg atcggagact tccaccgaga cctgttccgg
    19321 ctggcgccgt cgacgacgta cgcccgcgac tgggcagacc gcatgcgaga tgaatggagc
    19381 cgaacgtgac cagggtgatc gacctgcggc actacggaca gggaagcctc cccgagggct
    19441 tcaagcagat gctgatcgac gtgcacgctg acgcctacgc cgacgcgatg gacaacgagt
    19501 tcaaccagcg gttcccgtgg ttcgtcgatc actggtcagg gatggacggc ttcacctgcg
    19561 tcgtcgcctt cgacggcgac gagccgaccg gcttcgcgta cggcgccccg ctccagccgg
    19621 gccgtgagtg gtggcgttcc acggcgttcg caccgaacaa cggctacacc gcgacctacg
    19681 ccgtctccga ggtcatggtg cgcccgcagt ggcgggggca ggggatctcg gagcggctcc
    19741 acgaagccct gctgaaggaa cgcggtgaag accttgcggt gctcctggtc gacgtgacgc
    19801 acccgaaggt tcagggtttg tacgagacgt ggggctacga gaaggcgggc gagcagcggc
    19861 ccttcgccga ctctccggtt tacgcggtca tggtgaagag gctgtacgcc tgaacagccc
    19921 catctccgag tcacgtcact gctgtgccgt gtaccggtcg ccgggtagca cccgcggacg
    19981 cgcccggcga ggtcccgggg cccccggggg ccccgggacc tcgcccccgc gccacgatct
    20041 cccgggccag ggcggccagt ttcggcaggg cgggatggcc ggggccgtcg cggtgggcga
    20101 ggaggacggg gacgcccggg gcgtcgtcga gcggcacgta ggcgacgccc gggtgcgggt
    20161 gtatggcggc ggtggaggcg gccgagaccc cgctgccgcg cccggcggcg atggcggcca
    20221 gccagtcgtc ggtgttggcg acggtgaggg tggcggcggg ccgggcgtcc ggcggccaca
    20281 gttcgggggt cgtgatgccc gagacggtgt tcaggacgac ggggccgtcc accaggtcgg
    20341 ccaggcgcag cgacgtacgg gaggcgagcg ggccgtccgc cgtcaccgcc gccacccggc
    20401 cctcggtgaa cagcacctcg gtgacgagcc ccggcgcgtg gaccggtccg cgcagcagcg
    20461 ccgcgtcgac ctcgccccgg gtgagcccgg ccgtgcggtc gtcgatccgg agcaactcca
    20521 gcggggtggc cgggtggcgc tcccgccagg cgcgcaggag gggtgtggtg tacgggccga
    20581 aggccgacca ggcgtgcccg agccgcaggg gccagtggcg cagccgcccg gtgtccagcg
    20641 cctcgtcgaa ggcggccacc gccgcggcgg ccttgtcccg gaaggcgacg ccctcggggg
    20701 tgagggcgag atggtgggtg gagcggtcga cgagccggag gcccaggtgg cgttcgaggg
    20761 cggcgagcgt gcgggagacg gcgggctggg tgaggccgag gtgcgcggcg gcccgggtga
    20821 cgttgccctc ctcggcgacg gcgaggaagg cccgcagatg acgcagctcg acggcccggg
    20881 aggcaggggc cggggggtgg tcggggtctg cccggtgggt ggtgggtgcc gggggatggc
    20941 cgggctctcc ccgggcggtg gtgggtgccg ggggatggcc ggattctccc cgggcggtgg
    21001 tgggtgctgg gggatggccc ggttctcccc gcacggtggc gggcggagag gggtggccgg
    21061 gctctccccg cacggcggcg ggcgccgggc ggtgggcggg ttccgcccgg tgggaggcgg
    21121 gggccggggg gcggccgggg tttccccggt cggtcgcggg cgccgggtgg tggccggggg
    21181 gcgcggtgcg gcccgggtcc tcgggacggc tcatgcggtg cgctcccatc ggctcatgcg
    21241 cccggagcat aacgggagcg cagaagtcat ttcacgggag gcgcgcgggt ctctaccgtg
    21301 ggtgggcgcg ggcgtgccgc cccgccgctc cccgtacctc cgaaaggccg cccgtgaacg
    21361 tccagcgcag tgctccggag ccggccgccg ccgcggcggc cgtcgccgta cccgaggcgg
    21421 cacccgctct ggacgccgcc ggccggaagg gctccggacc gggcaggggc gcggcgctgg
    21481 tgccggtcgc gctggtggtc gcgggtggcc tgtcggtcca gttcgggtcg gccgtcgcgg
    21541 cgctgctgat gccgaaggcg ggcgcgctgg gcgtggtcac gctccggctg gcggcggccg
    21601 cgctgatcct gctggtggtg tgccggccga aggtgcgcgg ccactcgcgc gcggactggg
    21661 gcacggtgct cgccttcggc gtggcgatgg gcggcatgaa cacgctgttc taccaggcgc
    21721 tggaccgcat cccgctcggc atcgccgtca ccctggaggt gctcggcccg ctcgcgctct
    21781 ccgtcttcgc ctcgcgccgc ctggtcaacg tggtctgggc ggggctcgcc ctggtcggcg
    21841 tggtcctgct cggcggcggg ggcttcgacc gcctcgaccc ggtcggcgcg gcgtacgcgc
    21901 tgggggccgg ggcgatgtgg gcggcgtaca tcgtcttcag cgcccgcacc ggccgccgct
    21961 tcccgcaggc cgacgggctg gccctggcga tggtggtcgc cgcggtcctc tcactgccgc
    22021 tcggcatctg ggagtccggc gccaagctca ccgtcccctc caccctggcg ctcggcgcgg
    22081 cggtggcggt cctcagctcc gtcctgccgt acaccctgga actcatggcc ctgcgccggc
    22141 tgcccgcctc cacgttcgcc gtcatgatga gcctggaacc ggccatcgcg gccgcggcgg
    22201 gcttcctcat cctcaaccag gccctctcca cgacggacgc cctcgccatc gccctggtca
    22261 tcggggcgag catgggcgcg gtgcgcagcc agacggggac gcggaagcgg aagaagaagg
    22321 cgtgagtgtc gcggcgcgcc caggaccggc cgccggcggg ctcaccacgt acagggcgcc
    22381 tggaggtcgg tgaccgagtc ggccagttcg gccgggagcg tgggccagcc cgtgcggtgc
    22441 cagtgctcga tgcgccagga gaggcggcgc ggccagaggg ggagggcggg cagatcgggc
    22501 acggggatcc agaccggggt gccgccgtag gtgtccaggg tctcggcggg gccgatgccg
    22561 ccctcggccg tcaggaggaa gtagtgctcg tgccggccct ccttccagac ccgtgccacc
    22621 ttccgctcga cgctgccgtg gaggccggtc tcctcgcgga gctcccgtac ggccgcctcc
    22681 tccggcgtct cgcccgcctc caccccgccg cccgggatct cgtagtgcgg gccgccctcg
    22741 tccggctccc ggaagtggat gagcagcacg tgcccgtccc ggatcacgat cgcaccggcc
    22801 cggacccgta cgggaggaac ggctgccgga tcggccacct tcacctccac cgtctccgcc
    22861 ggtccggccc gctgcgccca ggcccgcagg acggcctccg ccgtaccggc cggccctatg
    22921 cgtgcgtgca gggcctcggt cagggtgagc gcgcgcaggg ggccggcggg ccccgtcgcc
    22981 gtaccgggaa agaggtagcg gacgtgatcc gcctcgcggt gttcctccag gacgagccgg
    23041 tcgccgtcga agtgcggttt caccaggtgg ggttcggcag tcatcggcgg agagtagcag
    23101 cggcggggcg gacgggcgcc ggtgtgtggc cgcgatccgg cctgacgggg cggagccgca
    23161 gcgggcatgt gccgaccggg cgtggacgcg tgtgccgggg acggtcgtcc tcagtggtcc
    23221 gcgggcacga tccggaaggc gtccagtccc ggcgtgagcg gggtcatggc ccggaagtcc
    23281 cgctggtcca gggtgaagat ccggtcggtc cgatagcggt cggccaggac caccccgacc
    23341 gcgtcggcca gatccagccg caggccctcg tacttctgcc ggacctcgtg ggcggtacgg
    23401 agatccgcga gcttgagttc ggcgaggcgg tactgcccgt cgtccatgcg ggagttcagc
    23461 gcctccatca cctgcagggc ggccgggaac cccaggtcgc ggtggaccag gtggtccagc
    23521 tcggtgacga ccaggggtga gatggccagc ctttcgtgtt ccaggatcct ggccgctgcg
    23581 gagtgctccg gctgtgcggc atcgaaggcg gcgtagaggg cggaagtgtc ggccacgatg
    23641 atcaacggcg tgcggcccgt tccttgatgt gctcgtacac cgagtcgtcc atctcgtccg
    23701 gtgtgcgggg acgcccgctg tcgaagaccg gcagctcaca gctccgcttc ggtcgctccg
    23761 cgtgctccag gagcagggcg atgccgcgcc ggatgagctc ggccttgctg atgccggtcg
    23821 cggccgcctc ggcgtcgagc cgcacttcca gatcctccgg aagatacacg gtcgtcttta
    23881 tcatgccgcc agcttaccac cctgccctac gtagggcagg gtggtgcttc ggcccgtacg
    23941 tcccgcctcc ctggcgcgtg tgaccgggcc ccggtgccga cgaggccgat gggtcgacgg
    24001 gttcgggcag aaaatcatgc aagcgtgctt gattgttttc tggtgcgctg ccatgctcct
    24061 gggcaccaca cccggtcccg aggggagcgc acgtgtccga tgtcgcagcg gtggtcgacg
    24121 atctgcgcga ggagagcggc gaactcaacg cgctggtcgg ggcgttggac gaggaggcct
    24181 ggcggggggc gacgcccgcc gaggggtgga ccgtcgccca ccagatcgcc cacctcgcct
    24241 ggaccgacga ggtcgcgctg ctggccgcca ccgagcccga gcggttcggg gacgaggtgg
    24301 cgaaggcgct cgccgccccc gacgccttcg tcgacgaggc cgccggcgcc ctggtcgccg
    24361 cccacgcccc gcgcgccctg ctcgcccggt ggcgggaggg gcggcggcgg ctcgacacgg
    24421 tgctgcggga ggccccggcg gggacccgga tcccctggta cgggccgccg atgagcgtcg
    24481 cctccatggc gaccgcccgc ctgatggaga cctgggccca cggccaggac gtcgccgacg
    24541 ccctcggggt cacccggacc cccaccgccc ggctgcggca tgtcgcccgg atcggggtgc
    24601 gggcccggaa ctacgcctac gcggtacggg ggatcgaggc gccggccgag gagttccggg
    24661 tcgaactccg ttcccccgga ggcgagatga tcgcgtacgg ccccgaacgc gccacccagc
    24721 gggtcaccgg gccactgctg gacttctgcc tcctggtcac ccagcgcgcc caccgctccg
    24781 acctcgccgt caccgccgag gggagcgagg ccgaccggtg gctctccatc gcccaggcct
    24841 tcgccggacc gcccggaccg ggccgcccac cccgcgccga gcaagccgga aaggccgagc
    24901 aggcctcaca cgccgaccaa gccgtgcgcg acgagcaagc cgcccgaggc gaccggtgac
    24961 cgccccaagc ccggcctcgg cacccggccc ggcctccgcc cccggcccca acccggtgac
    25021 cgcccccgcc cccgttctcc gtataggcaa cgcctccggc ttctacgggg accgcttcga
    25081 cgccgtacgc gagatgctca ccggcggccc cctcgacgtc ctcaccggcg actatctggc
    25141 cgagctgacc atgctcattc tcggccgcag ccgcctcaag gacccggaga aggggtacgc
    25201 caccaccttc ctgcgccagt tggaggaagg gctcggcctc gcccatgagc gcggggtgag
    25261 gatcgtgac
//
