LOCUS       NZ_KB890915            20723 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. CcalMP-8W B053DRAFT_scaffold_0.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KB890915
VERSION     NZ_KB890915.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. CcalMP-8W
  ORGANISM  Streptomyces sp. CcalMP-8W
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 859314)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   2  (bases 1 to 859314)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. CcalMP-8W
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:14:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,603
            CDSs (total)                      :: 6,529
            Genes (coding)                    :: 6,424
            CDSs (with protein)               :: 6,424
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 83 of 105
            Pseudo Genes (internal stop)      :: 5 of 105
            Pseudo Genes (multiple problems)  :: 18 of 105
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:04:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 526372
            Orig. end                         :: 547095
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB890915.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405361
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20723
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20723
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20723
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10723](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10723)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(99..1664)
                     /locus_tag="B053_RS01000000133335"
     CDS             complement(99..1664)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019604.4"
                     /locus_tag="B053_RS01000000133335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_078507601.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 6.7e-09, bitscore:
                     30.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSRQLSRNVAIGVVGGGAAAVCLLDALAGARTAPGEVTVFEPSP
                     HLWRGRPYQPDLDTVRVNIAPGGMSVRFGDPEHFPGWLAARDAVLGMAEPDFVDPINGL
                     RFIPRATYGAYLEQSAREAVARLREQGWRVDVVPERVTAAEPAPGGRVRLFHGDGESLT
                     VDHTVLCVGRGRPGDPYGLTGRDGYLPDAYPLARTLGEIGADADVGVIGAGLTGVDIVL
                     SLLARGHRGRVLLASRSGVLPRVRQTARPHTLKHFTAEWFRGAARRGETVTLGQVVDLM
                     RAEFADAGEDFTAVAREITAAAEAEDPVKRLRRHLSEVDSPDRGLRILQQAVPATGPDV
                     WPLLPESDRRQLLRDHYRSMMSLCCPMPATTATALLGMVDSGQLRIVPDVRAVEPAPGG
                     GFALRTGDGAPPLRADRLINAVNPAPGGLPARAQSLVTSLVSGGLAELHPRGGVVTERA
                     TSRLLTGGRAHPGLYALGDLAAGSLFFTFGLPSIVDRAHDIVQAISAGDGPPLPATEDA
                     VLSA"
     misc_feature    complement(513..515)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1745..1761)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.54"
                     /tool="antismash"
     gene            2176..3651
                     /locus_tag="B053_RS0102275"
     CDS             2176..3651
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552325.1"
                     /locus_tag="B053_RS0102275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldehyde dehydrogenase"
                     /protein_id="WP_018486989.1"
                     /sec_met_domain="Aldedh (E-value: 3.3e-162, bitscore:
                     535.6, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIGATAAEKRTVHHLIGGRSVASEDGRTFETRDPHDDALLGTVA
                     RGAARDGELAVTAAREAFDAGPWPRMTAAERRAVLHAVADAVDEHRDELALLESHDSGK
                     TLRHARHGEMPRVAQNLRFFADFAALATEEAYPDGPVLGYSLHAPAGVVSAISPWNAPL
                     MLATWKVAPALAFGNTVVLKPAPQTPLTAARFGELALEAGLPEGVLNIVHGYGGDEVAG
                     PLTGDPRVDRITFTGSSTTGAAIMAAAAANLTPVSAELGGKSANIVFADADLDIAVPES
                     IRAIFGGSGQVCFAGSRLLVQRSVLPEFLERFTAEAEKLVVGDPRQEGTFMGPLIGRAH
                     REKVHGYVELAQREGGTVLTGGGPPDDAALSGGHYYRPTVITGLDNDSRTAQEEIFGPV
                     ETVIPFDTEEEALRLANTTRYGLAGILFTRDLDRAHRMAARWKAGTVWVNCYFERDLRM
                     PFGGEGISGVGREGGNFSREFFTEPRAVVLRIR"
     misc_feature    2213..2228
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            3741..4541
                     /locus_tag="B053_RS0102280"
     CDS             3741..4541
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS0102280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018486990.1"
                     /transl_table=11
                     /translation="MTAHQDADTTSGTAARLYSAHRTGKPTASPGREGTVTTLADAYRV
                     QAEVVRLHTTGGERIRGLKVGLASSTARRALEGATEPVLGRLTSGMLRTTQLLPATDEL
                     IRPRAEPALLFVLGAPLEGPGANAADALRAVEFVLPALEITDSRVEDGPATVLDLAADN
                     AGCHSVVLGTEPVKPAGTDLRLAGYVLHRDGAVVATGATSMALGSPLAALAWAANARGD
                     DGFPLTAGSSVLVSGFATPTELPPGSTVTASLAGLGTATVTRAG"
     gene            4862..5662
                     /locus_tag="B053_RS0102285"
     CDS             4862..5662
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174136.1"
                     /locus_tag="B053_RS0102285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_018486991.1"
                     /transl_table=11
                     /translation="MAEALEIRPGDTRRAAAVLLEAERSVTARGPITAQWPTLDLPGAY
                     TVQYEALQQRLARGEKLIGVKLGLTSRAKQLRMGIDSPSLAWLTDAMVLPAGEPLPRER
                     LIHPRAEPEIVFVMGERLAGPGVTAATALRAVERVHAGIEIIDSRFQDFSFTLADAVAD
                     NSSSALFVLGPVGRSPEGLDLAHEAVLLEVDGEPVDSATGAAVQGHPAEALALAANALG
                     ERGLALEPGQLVLTGGMTDAVHVRPGSSVRASFSTLGAVSVAGG"
     gene            5665..5949
                     /locus_tag="B053_RS01000000133340"
     CDS             5665..5949
                     /EC_number="5.3.2.6"
                     /GO_function="GO:0016862 - intramolecular oxidoreductase
                     activity, interconverting keto- and enol-groups [Evidence
                     IEA]"
                     /GO_process="GO:0006725 - cellular aromatic compound
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013522.4"
                     /locus_tag="B053_RS01000000133340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="2-hydroxymuconate tautomerase"
                     /protein_id="WP_018486992.1"
                     /transl_table=11
                     /translation="MPFIDVTLGTGRSPEQVRALIHELTEAAHRAVGAPVANIRVVIRE
                     VAPQHWAAGDVTTAERAAARTADGAAPPSNSPQTVGGRPPAPAQEGSGT"
     gene            5946..6932
                     /locus_tag="B053_RS0102295"
     CDS             5946..6932
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013098.4"
                     /locus_tag="B053_RS0102295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_018486993.1"
                     /transl_table=11
                     /translation="MSDEQHRQEIAHLARVELHTPDPDGTLWFFKDLLGMYETRREGQS
                     VYLRGYEDPYQWSLKITEGPVARMDHAALRTTSPEALERRVRSLQAGNGEGAWTEDEYG
                     YGKTYDFTTPDGHHMSLLWEAEKYRAPEDLRSKILSRPSKKPLQGLPIKRLDHLNLLAS
                     DVTPMRNSFERHLRLRTNERVVDGEVEAGVWMSSSQLSHDVAVMRDARGARGRLHHVAF
                     YYGVQQHTVDAAEMFRDYDITIEAGPDRHGITQSSFLYVFEPGGNRIELFGDPGILILE
                     PDFETRTWTMDQIDTGTAIGGTNLPQETYFTYGTPPVPPEPAEDDAS"
     gene            7070..8329
                     /locus_tag="B053_RS0102300"
     CDS             7070..8329
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF001923.0"
                     /locus_tag="B053_RS0102300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Nramp family divalent metal transporter"
                     /protein_id="WP_018486994.1"
                     /transl_table=11
                     /translation="MTTPAPPKPAREATPIEVRRVRRAFYGPAFVAAVAYVDPGNFATN
                     FQAGANFGYLLVWVLVTANIVAMFIQYLSAKTGLATGKDLAALCGQRLPKPVAAGLWVQ
                     AELVVMATDLAEFVGAAIGLNLLFGVPLFPAGLATAVISFALLALQSRGYRPFELATTF
                     LLAVIGFGFLYQLVAVGGPDGGQLAEGLVPRLAGTESLTLAVGIIGATVMPHVIYLHSA
                     VTAGRLRPVGERAMRTALRALRTDCVGGLGMAGLINLAMLGVAAVLFHGAGGGFDGSLT
                     GAHEHLGRLVGGTAALAFAVALLASGLSSSGVGTYAGQVVMDGFIRRRLPLLLRRGLTM
                     LPALVVLALGVSPDDALIGSQVVLSFGIPFALAPLVYFTSRPALMGTLVNRRITTWTGT
                     VICVVLSALNLYLLVQLLFG"
     gene            complement(<8491..>8598)
                     /locus_tag="B053_RS1000000136410"
                     /pseudo=""
     CDS             complement(<8491..8598)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377440.1"
                     /locus_tag="B053_RS1000000136410"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS5/IS1182 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRAPGLLTILREHDPDVVLLDGTLAECDRVGDSRAD"
     gene            complement(8615..9838)
                     /locus_tag="B053_RS0102305"
     CDS             complement(8615..9838)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS0102305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018486995.1"
                     /transl_table=11
                     /translation="MTEDDAVQVTFRSFRSRKDGDEWIVGRVETGQILALPDVGMAAVR
                     LLMEGRTIAQTRAELREVSGRDINVRSLAEDLARSGLVSAIGLRTFSQQPTKVTLPALK
                     MRHSRWAVHPATHAVILTVALSGLVAAAVEPTILPGWSDLLWTDYGTFVLFTQSLVAWC
                     LILLHEMAHLLTARAVGVPGRVRLGTRLQFLVVQTEVTGIWLSGRRERLTVYLSGIALD
                     AAIAGGCLLAIAAGHGSPLLVVTILTVFYAFMGQCLVFMRTDLYFVVQDLTGCRNLYSD
                     SAAYLRALGRRFLLRPAQNPLASRCESERRAIRVFAVLMVIGTTACIAVAVQLLRDVTW
                     ALVARSITVLLHSNGIRARLADAVVYRSDTVGTAPPTRPEHVPLVAGTASRGSAGTTDR
                     SVKAGRCA"
     gene            complement(10001..10723)
                     /locus_tag="B053_RS1000000135370"
     CDS             complement(10001..10723)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013094.4"
                     /locus_tag="B053_RS1000000135370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_234017915.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 7.6e-16,
                     bitscore: 53.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 1.7e-26, bitscore: 88.5,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYPRVKEEHEPYRFDDGTIRIGGELYGTAAEIVDSNGWAWDALS
                     LMDGKTSVTRIVDDLASRYTSLGHIGARKVIVKLLDSGHIEDSEVETPAGLDPHEVERY
                     SRNHAFFRRVDLRPRVNPWEDQLSLKRARVLLLGVGGVGSHAAWSLAAAGVGSLHCIDP
                     DAVEESNLTRQVLYAESDIGRPKAEVAVEGSRQSTLQGHSHTSSEWWTQRRNFRTSYPD
                     LMYSLCARTSHAKGSLRV"
     aSDomain        complement(10460..10720)
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B053_RS1000000135370_Pantocin_Microci
                     n_RRE.1"
                     /evalue="2.90E-17"
                     /identifier="RREFam017.1"
                     /label="B053_RS1000000135370"
                     /locus_tag="B053_RS1000000135370"
                     /protein_end="88"
                     /protein_start="1"
                     /score="53.5"
                     /tool="antismash"
                     /translation="KYPRVKEEHEPYRFDDGTIRIGGELYGTAAEIVDSNGWAWDALSL
                     MDGKTSVTRIVDDLASRYTSLGHIGARKVIVKLLDSGHIEDS"
     misc_feature    complement(10681..10695)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            complement(10785..10916)
                     /locus_tag="B053_RS1000000137845"
     CDS             complement(10785..10916)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS1000000137845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018486996.1"
                     /transl_table=11
                     /translation="MAEKDLTEKFTGDIGGSDEQEAELIEIRLLDKIETIQNKHQDG"
     gene            complement(10980..11633)
                     /locus_tag="B053_RS1000000135375"
     CDS             complement(10980..11633)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="B053_RS1000000135375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_158690010.1"
                     /transl_table=11
                     /translation="MIERLWAAEVPQHPRQALYTYAARLRQALDVGGSRTRDSPLVRRP
                     GGYLFDIERDSVDLFRFRNLSRSAKSAAYRGDNTMAVHLFDDALALWHGDPLSDLDRGW
                     AEGARISIRREYRAVIVGRAEASLCVGRHEEHLPALHQLAADYPEDERIAGLLMLSLYR
                     SGRQGEALACFSNIRSRLIRQLGDEPGSMLQILHSQVLRRDPGLSHIDGLPVAN"
     misc_feature    complement(11614..11629)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.23"
                     /tool="antismash"
     gene            complement(12397..14256)
                     /locus_tag="B053_RS0102315"
     CDS             complement(12397..14256)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995191.1"
                     /locus_tag="B053_RS0102315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_234017916.1"
                     /transl_table=11
                     /translation="MEENDSPKIFPARAAVAALGLAFRASPLLVFAYVVLALASGSLPV
                     AIGWLTKLIVDGLVDGVSLERAITLGSALAVAGLLQGIAPIVSRFLGAELGREIGLIAQ
                     ESLFTAVNRFIGLAPFESPNYLDRMRLAKRSGQDGPHQVLDGGLGTVRSLITITGFVGS
                     LFILAPLMACFILAFGIPVLVAEIALSRVRAKMLWQIGPTERREMFYDQLLSSEEAAKE
                     VRLFGLGDFLLGRMQKERRASNSAKRRADRHQVLVQSTLTLLATILSGAGLLWAVKSVS
                     AGELSVGDIAIFIAAVAGIQGALTQLAVDSARVHQALSLFEHYLAVTKAPSDLPVPRDP
                     LEIPPLRHAIELRDVWFRYSDDHPWILRGVNLTISQGKSLALVGLNGAGKSTLVKLLCR
                     FYDPTRGAILWDGIDLREVDAAQMRARMGAVFQDHMHYDMTAHENIGLGDLRAIDDSPL
                     IEEAAVNAGIHDVIASLPKGYETLLTRIFLMEADKDNEETGIVLSGGQAQRLALARAFL
                     RGRRDFVILDEPASNLDAEAEHEINSSLRRHRDGLTTFLISHRLGSIRNADHIVVLSNG
                     RIVEQGAHSELMAHEGDYARLFALQASGYQEEADSVPLGQAGR"
     misc_feature    complement(12793..12795)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14285..14857)
                     /locus_tag="B053_RS1000000136840"
     CDS             complement(14285..14857)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS1000000136840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_146225523.1"
                     /transl_table=11
                     /translation="MAILFSVLALLVASAGCALSLAVALRVKRLLDPLVEEGGVGTGRR
                     PRGIPLGTPVPGVGAMTDVHGERVEFPAQDGAQWILTFQSTGCSGCKQQLPEYKKFLET
                     SGIARDRVFSLILGDEEGVSLYADELRDVSRVVHSGESVDRVVREMGVTVWPTYSVIDG
                     SGNVSYSVQSSARLTGDETPVSPVRVS"
     misc_feature    14858..14873
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.24"
                     /tool="antismash"
     misc_feature    14860..14874
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 23.63"
                     /tool="antismash"
     misc_feature    complement(14862..14873)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            complement(14876..15379)
                     /locus_tag="B053_RS01000000133345"
     CDS             complement(14876..15379)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0030416 - methylamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018942.4"
                     /locus_tag="B053_RS01000000133345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MauE/DoxX family redox-associated membrane
                     protein"
                     /protein_id="WP_018486998.1"
                     /transl_table=11
                     /translation="MVIFCQILMATVYLLSAILKLRELSAFRAHLISTMPGVRPFASFL
                     AAGVVATEIGTALALMVIRPAWIGFSLSVLLLAGFTLYLVAMLRTRRGASCGCVGDGGG
                     PISGVHVTRNILLVMVSGAGALLATGMGDTPAFAFYFSLGPAVIAGALLLYLDEIVSFF
                     KMAT"
     gene            complement(15669..15839)
                     /locus_tag="B053_RS1000000136845"
     CDS             complement(15669..15839)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS1000000136845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018486999.1"
                     /transl_table=11
                     /translation="MSKAITNLVMKVADRLLPKTEAAAGCPEYCETWWTGTVWRKCCFY
                     ANCTANCVNIG"
     misc_feature    15925..15940
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.43"
                     /tool="antismash"
     misc_feature    16043..16058
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            16517..19003
                     /locus_tag="B053_RS01000000133350"
     CDS             16517..19003
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="B053_RS01000000133350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_158690012.1"
                     /transl_table=11
                     /translation="MTVDEVRFRVLGPLEVEIGRQPVALTGRQRGLLAALLLSPNQVVS
                     VACCADRLWGERAPSTAPARVRALVTELRRALHIEGRRLIVTRSPGYSILLQDDELDVV
                     EFACLLDEAGRSAQRKRFSQAIDQYDGALALWRGDPFVDLEAMEVGVEARRLGEARALA
                     IVSRAECHLSSGRAAEAIEDLMAFTAEQPLREPPRGQLMRALGHSGRRSEALEVYEDYR
                     IVLQEELGVEPSDELRRLRLSMIEGGGVPTGGVSTVPVAIGPRRPVGPRQLPPRTPRFT
                     GRREELRRLDEMHADREPTVLLVGGAGVGKTSLALHWADRVAARFPDGQFYLNMRGFDR
                     SEPMPVTEALPILLQGLGWSARDVPVDPGAQVALYRSLLSSRRTLLVFDNVADVRQVRE
                     LLPGGSHCMSVVTSRDRLEGLVALDGARRLTLNVFDGEEALGLLRRGLGENRTQREPEA
                     AAELVELCDRLPLALSIATAWIADQEHRTIGQYIARLTRQGRLAQLKVEGDEYAAVRAA
                     LDLSYEALPVTAQRAFRLLGVVPHAGVSARAAAAQIDSAPDTADDLLSAIARVHLMSES
                     GVQRYSWHDLVKEYAAERAAVEDPPEQREAAVRRLLAHYFLSVIDLVDVCGYQPPSMPY
                     DVDEVPCAGPSVFDGPEEGLAWFDAEWKNILLAITYAAEHGPPGYAPLIVDALQDLLQH
                     HRPYTEWLRISATAMAAAQRQSDMAGQAAMHLSQGLALLRMADLEASLAQNKAGLELSR
                     RVGWRAGEANALQGCGVALKQLGEAEQALLMYRQAQEINHDLRLLRGEARCLSECLDSW
                     PVDAFSTIGGRGQPNG"
     gene            complement(18988..19446)
                     /locus_tag="B053_RS1000000135385"
     CDS             complement(18988..19446)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538322.1"
                     /locus_tag="B053_RS1000000135385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_078507615.1"
                     /transl_table=11
                     /translation="MSHPRVRVAAYVIRQQDVPELLVFDHVDYPEAGTQIPAGGVQPGE
                     SLEEAVLRETPEETGLQTARIIGQLAVEDKPHPQTGHPRRTNFFHLQASADTPDAWVHR
                     VLSDGSDASMIFSCRFLPIPLQLPLADDQDTWLDRINRDWRTRTQPLG"
     gene            complement(<19513..>20093)
                     /locus_tag="B053_RS1000000137345"
                     /pseudo=""
     CDS             complement(<19513..20093)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003978807.1"
                     /locus_tag="B053_RS1000000137345"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVIAFLRDQLRRQIRTDQGRYPWPVTLIVDSQSVKGAETVSKATR
                     GFDAGKKINGRKRHIAVDTLGLPVMITVTPADTTDRDAARELLWRLRVMQPRITQVWAD
                     SAYAGRLVNWTCDFLNMTLKTVSPAARKASSSCPAAGRLNAPSAGS"
     misc_feature    20349..20363
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 23.72"
                     /tool="antismash"
     gene            20396..>20646
                     /locus_tag="B053_RS1000000135395"
                     /pseudo=""
     CDS             20396..>20646
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011039462.1"
                     /locus_tag="B053_RS1000000135395"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPGGATAGPVRVRGLTDQEGRKPQRIVRRGSTSTVRGGGSAGR"
ORIGIN
        1 cggcggacgt tcgggcgccg gggcgcagcc ggtcgggtgc cgggcgccgg acgggcaggt
       61 gccgggcggt cgggcggcag acggcagacg gcagatcttc aggcgctgag tacggcgtcc
      121 tcggtggcgg gcagcggcgg gccgtcaccg gcgctgatcg cctgcacgat gtcgtgggcg
      181 cggtcgacga tggaggggag cccgaaggtg aagaacaggc tgcccgcggc caggtcaccg
      241 agcgcgtaga gaccggggtg ggcccgtccg ccggtcagca gccggctggt ggcccgctcc
      301 gtcacgacgc cgccgcgcgg gtggagttcg gccagccccc cggagaccag cgaggtgacc
      361 agcgactggg cgcgggcggg cagcccgccg ggcgccgggt tcaccgcgtt gatcagccgg
      421 tcggcccgga gcggcggcgc cccgtccccc gtacgcaggg cgaagccgcc acccggcgcc
      481 ggctccacgg cccgtacgtc ggggacgatc cgtaactgcc cgctgtcgac catgccgagc
      541 agggcggtgg cggtggtcgc cggcatgggg cagcacaggc tcatcatcga gcggtagtgg
      601 tcgcggagga gctgtctgcg gtcggactcc gggagcagcg gccagacgtc gggaccggtg
      661 gcgggcaccg cctgctggag gatgcgcagc ccccggtcgg gcgagtccac ctcggacagg
      721 tgccggcgca gccgcttcac cgggtcctcg gcctccgcgg cggcggtgat ctcccgggcc
      781 acggcggtga agtcctcgcc cgcgtccgcg aattcggccc gcatgaggtc gaccacctga
      841 cccagggtca ccgtctcccc gcgccgggcc gcgccccgga accactcggc cgtgaagtgc
      901 ttcagggtgt gcggccgggc cgtctggcgg acccggggga gcactccgct gcgcgaggcc
      961 agcaggaccc ggccccggtg cccgcgggcg agcagcgaga ggacgatgtc gacgccggtc
     1021 agcccggcgc cgatgacgcc gacgtcggcg tcggcaccga tctccccgag ggtgcgggcc
     1081 agcgggtagg cgtcgggcag atagccgtcc cggccggtca gcccgtacgg gtcgccgggc
     1141 cggccccggc ccacgcagag cacggtgtgg tcgacggtga ggctctcgcc gtcgccgtgg
     1201 aacagccgca cccggccgcc gggggcgggc tcggcggcgg tgacccgctc ggggacgacg
     1261 tcgacccgcc acccctgctc gcgcagccgg gcgacggcct cgcgggccga ctgctccaga
     1321 taggcgccgt aagtggcgcg cgggatgaag cggagcccgt tgatcgggtc gacgaagtcg
     1381 ggttcggcca tgccgagcac cgcgtcccgg gcggccagcc agcccgggaa gtgctccggg
     1441 tccccgaagc gtacggacat ccccccgggc gcgatgttca cccggaccgt gtccaggtcc
     1501 ggctggtagg gccggccgcg ccacagatgg ggcgagggct cgaagacggt gacttcgccg
     1561 ggggccgtcc gggccccggc gagcgcgtcg agcagacaga cggcggccgc ccctcccccg
     1621 accacgccta tggcgacatt ccggctcagc tgtcttgagc ccatggttaa cacgtccccc
     1681 tcggagcact ggtgaccagc aagagaaata cggcaggaaa gcggaacagg cggagacaag
     1741 gcatcggaaa gaaatcaaca aggagaagag gaaagggaaa gctggggccg acggacggcc
     1801 gcggcggcgg aaccccgcgg gaccgtcccg cacaggccga cggcccgcgg gcttcggggc
     1861 cgagcgcctc actcggctcc cgtatcccgt tccgacgcca acgacgctac ccagccgccg
     1921 attcgccggt caacagccgg caccacgcga tacaagtccc aaaaacgggt caacagaaag
     1981 gactcttctt gaccggccgg acgggcggat cgcaggatga atacgcgtcg gacgcatttc
     2041 gaccccgcgc atccactgcc cttgaatcgc gcagccggaa cgcggtcgcg ccggaatcca
     2101 ccggcccgcc gcacccgttc gaccacccac tcacccgcac caccaccgga aatccggaat
     2161 ccagggggta ttcgcatgtc catcggcgcc acggccgcgg aaaagcggac ggttcaccat
     2221 ctgatcggcg gccgctccgt cgcctccgag gacgggcgca ccttcgagac ccgcgacccg
     2281 cacgacgacg cgctgctcgg caccgtcgcc cggggcgctg cgcgggacgg cgagctggcc
     2341 gtcacggcgg cgcgcgaggc cttcgacgcg gggccctggc cccggatgac ggcggccgag
     2401 cggcgggcgg tcctgcacgc ggtggccgac gcggtcgacg aacaccggga cgagctggcc
     2461 ctgctggagt cccacgacag cgggaagacc ctccgccacg cccggcacgg ggagatgccc
     2521 cgggtcgccc agaacctacg gttcttcgcg gacttcgcgg ccctcgccac cgaggaggcc
     2581 taccccgacg gcccggtgct cggctactcg ttgcacgccc cggccggagt ggtctccgcg
     2641 atcagcccgt ggaacgcgcc gctcatgctg gccacctgga aggtcgcgcc cgcgctggcc
     2701 ttcggcaaca ccgtcgtact gaagccggcg ccgcagaccc cgctgacggc ggcccggttc
     2761 ggggagctgg cgctggaggc ggggctgccg gagggagtcc tcaacatcgt gcacgggtac
     2821 ggcggtgacg aggtcgccgg gccgctgacc ggtgacccgc gcgtggaccg gatcaccttc
     2881 accggctcca gcaccaccgg ggcggccatc atggcggcgg cggcggccaa cctgacgccg
     2941 gtctccgccg agctgggcgg caagtcggcc aacatcgtct tcgcggacgc ggatctcgac
     3001 atcgcggtgc cggagtcgat ccgggccatc ttcggcggga gcggccaggt ctgcttcgcc
     3061 ggttcgcggc tgctcgtgca gcggtcggtc ctgccggagt tcctggagcg gttcaccgcc
     3121 gaggccgaga agctggtggt cggggacccg cgccaggagg ggacgttcat gggtcccctc
     3181 atcgggcggg cgcaccggga gaaggtgcac ggttacgtcg agctggcgca gcgggagggc
     3241 ggcacggtcc tcaccggcgg cggcccgccg gacgacgccg cgctctccgg cgggcactac
     3301 taccggccca ccgtgatcac ggggctggac aacgactcgc gcacggccca ggaggagatc
     3361 ttcggcccgg tggagacggt catcccgttc gacaccgagg aggaggcgct gcggctggcg
     3421 aacaccaccc ggtacgggct ggcgggcatc ctcttcaccc gcgacctgga ccgcgcacac
     3481 cggatggcgg cccgctggaa ggccggcacc gtctgggtca actgctactt cgagcgcgat
     3541 ctgcgcatgc ccttcggggg cgaggggatc agcggtgtcg gccgggaggg cgggaacttc
     3601 tcccgcgagt tcttcaccga gccccgggcc gtggtcctgc gcatccgctg acggccgcac
     3661 cgcgcgctct cccccgcacc gccgaccacg tcacccgggc cccggcccac cgcaggaaca
     3721 ccgagaggca cgcatccatc atgaccgcac atcaggacgc cgacacgaca agcgggacgg
     3781 ccgcacggct gtacagcgcc caccgcaccg gaaagccgac cgcgtcgccc ggccgcgaag
     3841 gtacggtgac gaccctcgcc gacgcctacc gcgtacaggc ggaggtggtg cgcctgcaca
     3901 ccaccggggg cgagcggata cgcgggctga aagtgggcct cgcctcctcc accgcgcggc
     3961 gcgccctgga gggggcgacg gagccggtgc tcggccggct gacctccggc atgctccgta
     4021 cgacccagct cctcccggcc accgacgagc tgatccgtcc gcgggcggaa cccgcgctgc
     4081 tgttcgtcct cggcgcaccg ctggagggcc ccggtgcgaa cgcggccgac gcgctgcggg
     4141 cggtggagtt cgtgctgccc gcgctggaga tcaccgactc ccgggtggag gacggcccgg
     4201 ccaccgtcct ggacctggcc gccgacaacg cggggtgtca ctccgtggtc ctcggcacgg
     4261 agccggtgaa gcccgccggc accgatctgc ggctggccgg atacgtgctg caccgcgacg
     4321 gggcggtcgt ggcgaccggg gccaccagca tggcactcgg ctcgcccctg gcggcgctgg
     4381 cctgggcggc gaacgcccgg ggggacgacg ggttcccgct cacggcgggc agcagcgtcc
     4441 tggtctccgg cttcgccacg cccacggagc tgccgcccgg ctccacggtg acagcctcgc
     4501 tggcggggct gggcacggcg acggtcaccc gggcgggctg acgcccgggg cggattcccc
     4561 gcccgagcgg ggactgccgc gagaacgggg ccgcgcgcga gcaacgactc acgtacgagc
     4621 gggcccgcgc acgcgcaacg ccccacaccc gagcggggat ccccacccga gcagggccca
     4681 cacccgagca cgcaccacac ccgggcaggg accacacccc agcggcgccg gcccacgggc
     4741 ggagccccgt cggcccacct ccgtaccgca cagcgcaccc acacgcaccc acacgcaccc
     4801 gccctccccc accgactccc cagccccacc ccaccccacc ccttcgagga ggaggccgtc
     4861 catggccgag gcactggaaa tacgaccggg tgacacgcga cgtgccgccg cggtcctgct
     4921 ggaggcggaa cgctccgtca ccgcgcgggg cccgatcacc gcgcagtggc ccacgctcga
     4981 tctgccgggc gcctacaccg tgcagtacga ggcgctgcaa cagcgcctgg cccggggcga
     5041 gaagctcatc ggggtcaagc tgggcctcac ctcgcgggcc aaacagctgc ggatgggcat
     5101 cgactcgccc tccctggcct ggctgacgga cgccatggtg ctgcccgccg gcgaaccgct
     5161 cccgcgcgaa cggctgatcc acccgcgcgc cgagccggag atcgtcttcg tgatgggcga
     5221 gcggctggcc gggccgggtg tcacggcggc gaccgcgctc cgggcggtgg agcgggtgca
     5281 cgccgggatc gagatcatcg acagccgctt ccaggacttc tccttcaccc tggccgacgc
     5341 ggtcgcggac aacagctcct ccgcgctctt cgtcctgggc ccggtcggcc gctcgcccga
     5401 gggactggac ctggcgcacg aggcggtgct gctggaggtg gacggcgagc cggtcgactc
     5461 ggccaccggt gccgccgtcc agggccaccc ggccgaggcg ctggcgctcg cggcgaacgc
     5521 cctgggcgag cgcggactcg ccctggagcc gggccagttg gtcctgaccg gcggaatgac
     5581 cgacgcggtc cacgtacggc ccggttcgag cgtccgcgcg agcttctcca ccctcggcgc
     5641 cgtatccgtg gcggggggct gaccgtgccc ttcatcgacg tcaccctcgg caccggccgc
     5701 tcgcccgagc aggtacgcgc cctgatccac gaactcaccg aggcggcgca ccgggccgtg
     5761 ggcgccccgg tcgcgaacat ccgggtcgtc atccgcgagg tcgcgcccca gcactgggcg
     5821 gcgggcgacg tgacgacggc ggagcgcgcg gcggcccgta cggcggacgg cgccgcccca
     5881 ccgagcaact ccccacagac cgtgggcggc agaccgcccg caccggcgca ggaaggcagt
     5941 ggcacatgag cgacgaacag caccggcagg agatcgcgca cctcgcgcgg gtcgagctgc
     6001 acacccccga cccggacggc accctgtggt tcttcaagga cctgctgggc atgtacgaga
     6061 cccggcgcga gggccagtcg gtctatctgc gcggctacga ggacccgtac cagtggagtc
     6121 tgaagatcac cgagggcccg gtggcccgca tggaccacgc ggcgctgcgg acgacgtcgc
     6181 cggaggcgct ggagcgccgg gtgcgctcgc tgcaggcggg gaacggcgag ggagcgtgga
     6241 cggaggacga gtacgggtac ggcaagacgt acgacttcac cacccccgac ggccaccaca
     6301 tgagcctgct gtgggaggcg gagaagtacc gggcgccgga ggacctgcgc agcaagatcc
     6361 tcagccgccc gtcgaagaag ccgctccagg ggctgccgat caagcgtctg gaccacctca
     6421 acctgctggc cagcgacgtc accccgatgc ggaactcctt cgagcggcac ctgcggctgc
     6481 ggaccaacga gcgggtggtg gacggtgagg tcgaggccgg ggtctggatg agcagcagcc
     6541 agctcagcca cgacgtcgcc gtcatgcgcg acgcccgggg cgcccggggc cggctgcacc
     6601 acgtcgcctt ctactacggg gtgcagcagc acacggtgga cgcggcggag atgttccgcg
     6661 actacgacat caccatcgag gcgggccccg accggcacgg gatcacgcag agctccttcc
     6721 tgtacgtctt cgagcccggc ggcaaccgga tcgagctgtt cggcgacccg ggcatcctga
     6781 tcctggagcc ggacttcgag acccgtacgt ggacgatgga ccagatcgac acggggacgg
     6841 cgatcggcgg gacgaacctg ccgcaggaga cgtacttcac gtacggcacg ccgcccgtac
     6901 ccccggagcc ggccgaggac gacgcgagct gagcggggcc ccgggacgcc ggacgacacc
     6961 caggcgtccc ggggcagccg cacacctcca gccctcctgg gcacccggcc actcacgcat
     7021 cggcacacgc atgcccccgc ccgccccggc ccgaagggac gaaccacgca tgaccacgcc
     7081 cgcacccccg aagccggcca gggaggccac cccgatcgag gtgcgccggg tgcgccgggc
     7141 cttctacggt ccggccttcg tcgccgcggt ggcctatgtg gacccgggca acttcgcgac
     7201 caacttccag gcgggggcca acttcggcta tctgctggtc tgggtgctgg tgacggcgaa
     7261 catcgtcgcc atgttcatcc agtacctgtc ggccaagacg ggcctggcga cggggaagga
     7321 cctggcggcg ctctgcgggc agcggctgcc gaagccggtg gcggccgggc tgtgggtcca
     7381 ggccgaactg gtcgtgatgg cgacggacct ggccgagttc gtgggcgcgg cgatcgggct
     7441 gaacctgctc ttcggggtgc cgctcttccc ggccgggctg gccacggccg tcatcagctt
     7501 cgcgctgctg gccctgcaga gccggggcta ccggcccttc gagctggcga ccacgttcct
     7561 gctggcggtg atcgggttcg ggttcctcta ccaactggtg gcggtgggcg gcccggacgg
     7621 cgggcagctg gcggaggggc tggtcccgcg gctggcgggt acggagtcgc tcacgctggc
     7681 ggtcgggatc atcggcgcga cggtgatgcc gcacgtgatc tatctgcact cggcggtgac
     7741 ggcgggccgg ctccggccgg tgggcgagcg ggcgatgcgg acggccctgc gcgcgctgcg
     7801 cacggactgc gtggggggcc tggggatggc cgggctgatc aacctggcga tgctcggtgt
     7861 cgccgcggtc ctcttccacg gcgcgggcgg gggtttcgac ggctccctga ccggggcgca
     7921 cgagcacctg ggccggctgg tgggcggtac ggcggccctg gcgttcgcgg tggcgctgct
     7981 ggcgtcgggc ctgtcctcgt cgggcgtggg cacctatgcc gggcaggtgg tgatggacgg
     8041 cttcatccgc cgccgcctcc cgctcctgct ccgccgcggc ctgaccatgc tgcccgccct
     8101 ggtggtcctg gccctcggcg tctcccccga cgacgcgctg atcggctccc aggtggtgct
     8161 ctccttcggc atccccttcg ccctggcccc gctcgtctac ttcaccagcc gccccgccct
     8221 gatgggcacc ctggtcaacc gccggatcac cacctggacg ggcacggtga tctgcgtggt
     8281 gctctccgcc ctgaacctgt acctgctggt ccagctgctc ttcggctgag ggggccgggg
     8341 ctgatcccgt acgcgtcccg aaggtccgag agaaccgagg tggagcggct gggacctcga
     8401 tgggtgccgc ttctcacctg cggaaaggca accacggtgc cgtgcgctac gtacctcggg
     8461 ccatggggcg ctcccggtgc tcgccgagca gtcggcacga ctgtcgccga cgcgatcgca
     8521 ctctgcgagc gtcccgtcga ggaggacgac gtcggggtca tgctcgcgca ggatcgtcag
     8581 caggcccggg gctcgatcga cgggcaggcc ggtttcacgc gcaccggccc gccttcacgc
     8641 tccggtcggt ggttccggct gatccccgcg aggcagtccc cgcgaccagt ggcacgtgct
     8701 caggacgagt gggcggcgcg gtgccgaccg tgtccgagcg atacacaacg gcatccgcaa
     8761 gtcgggcccg gatgccgttg ctgtgcagca gcacggtgat cgaacgggcc accagtgccc
     8821 aggtgacgtc ccgaagaagt tgaactgcca cagcgatgca cgctgtcgta ccgatgacca
     8881 tgagcacggc gaagacgcgt atcgccctgc gctccgactc acagcgcgag gccagtgggt
     8941 tctgggctgg tcggagcagg aagcgacgcc ccagggctcg caagtacgcg gcggaatcgc
     9001 tgtacagatt gcggcaaccg gtgaggtcct ggacgacgaa gtagagatcg gtgcgcatga
     9061 agaccagaca ctgccccatg aaggcgtaga aaacggtgag gatggtaacg accaggagcg
     9121 ggctgccatg acctgcggct atggccaaca gacagccacc tgcgatcgcc gcatcaaggg
     9181 caataccgga cagatatacc gtcagacgtt cgcgacggcc gctgagccag atccccgtca
     9241 cctccgtctg gaccaccagg aactgcaagc gagtacccag tctcacgcgg cccgggacac
     9301 caacggcccg tgcagtaagc aggtgggcca tctcatggag aagaatcagg caccacgcca
     9361 cgagagactg cgtgaacagc acgaacgttc catagtcagt ccatagcaag tcactccagc
     9421 cgggcaggat cgtgggctct accgctgctg ccaccaggcc gctgagggcg acggtgagga
     9481 tgacggcgtg cgttgccggg tggacggccc accgggagtg ccgcatcttc agtgccggca
     9541 gagtcacctt ggtgggctgt tgagagaacg tccgaaggcc gatcgcggag accagccccg
     9601 aacgggcgag atcctccgcc agtgaacgga cattgatgtc acgccccgag acctcccgca
     9661 gctcggcccg agtctgcgcg atggttcgcc cctccatcag gagcctcacc gctgccatgc
     9721 ccacgtccgg cagcgctagg atctggccgg tctccacacg tccgacaatc cattcatcgc
     9781 catccttgcg ggacctgaag gaacggaagg tcacctgcac cgcgtcgtcc tcggtcatgg
     9841 cttcgccgac cggaggctgt cctgctgatg gggacggcac aactcacacc caggacgggc
     9901 tagcacggcc cggtgggggc gtacacaccc acggcgacca tcggcccatt atatccggcg
     9961 gatacccaag gcactcctcg gtcagcgcac acccgattgg tcagactcgc aatgaaccct
    10021 tggcgtggct cgtccgcgca cagagcgaat acatcaaatc cggatacgag gtccgaaagt
    10081 tccgcctctg tgtccaccat tcgctgctcg tatgagaatg accctgaaga gttgactgcc
    10141 gagagccttc gacggcgacc tcagcttttg gtctcccaat atcagactcg gcatacagga
    10201 cctgccgcgt cagattggat tcctctaccg catcagggtc gatgcagtgc agtgagccga
    10261 cacctgcggc tgcaagtgac catgcggcat gactaccgac gcccccgacg ccgagaagaa
    10321 ggacccttgc cctcttcagg ctgagctgat cctcccatgg attgacccgc ggcctcagat
    10381 ctacgcgccg gaagaaggcg tgattcctac tgtatctttc gacctcatga ggatcgagcc
    10441 ccgctggagt ttccacctcg gagtcctcga tgtgcccgga gtccagaagt ttcacaatca
    10501 cctttcgggc accgatgtga cccaaagatg tataccggga cgccaggtcg tccacaatcc
    10561 gggtgacgga agtctttccg tccatcaagc tgagcgcgtc ccaggcccat ccattcgagt
    10621 cgacgatctc cgctgcagtc ccgtacagct cgccaccaat tcgaatcgtc ccgtcatcga
    10681 atcgataggg ttcatgctct tccttgaccc gcgggtattt catcgtgaac ctcccccgcc
    10741 tggggtggca gagcgagacg ctctgccacc ccagaccatc cggactatcc gtcctggtgc
    10801 ttgttctgga tggtctcgat cttgtcgaga agccggattt cgatcagttc ggcttcctgc
    10861 tcatccgaac cgccgatgtc gccggtgaac ttctccgtga gatccttctc cgccatgtgt
    10921 ttcccctccg tgaaagaaat aactttcgcc gacggcgaaa accgaccggc ggctaaaaat
    10981 caattggcca ccggaagtcc atctatatga ctcagccctg gatctcttct cagaacttgg
    11041 gaatgcagta tctgcagcat ggagccgggt tcgtcaccga gttgccgaat cagtcgtgag
    11101 cgaatgttac tgaaacaggc cagtgcttcg ccctggcgtc cgctgcgata aagggagagc
    11161 atgagaagac ctgcgatcct ctcgtcttcc gggtagtctg cggcgagttg atgaagtgcg
    11221 ggtaggtgct cctcatgtcg accgacacac aaactggcct cagctcttcc gacgatcact
    11281 gctcgatact cacgccgaat gcttatacgt gccccttcgg cccaccctct gtccaggtcg
    11341 gacagcggat caccgtgcca cagagccagt gcgtcatcga acagatgcac cgccatggtg
    11401 ttgtcccccc ggtacgcggc acttttcgct gaccgcgaca gattccggaa tcgaaagaga
    11461 tcgactgaat ctctttcgat atcgaagaga tagcccccgg ggcgtcgcac gaggggggag
    11521 tcacgagtgc ggctaccgcc gacatccagc gcctgcctca accgggcagc gtaggtgtag
    11581 agcgcttggc gcggatgctg ggggacttca gctgcccaca gccgttcgat catgacctcg
    11641 tccgacacaa agctgccagg ggaccaagcc agagaagcaa ggaaacgtct gacggctgta
    11701 tggagcatga tcttgccggc cgacgtgtgt acttgaacac agccgagaag ccgcacatcc
    11761 atgtggtacc tgccgttcgt taggtggtgg ccacaaacct ggcagtcggt gcgcatggat
    11821 gacgcatgga tcgtgcatgg ccgggcgccc ggcgtggtgt cacggccagg tcggtcgacc
    11881 cggttccgcg acgagggctc cgtggacggt gaggttcacg tggccccgtg ccgatgccct
    11941 tccctcagaa gcgtctccag accgttccca gcacgtgctc cgaggagaag aagcccaatt
    12001 gccgagagtc gaggctgacc gatgcattgt cgccgagaag gaccaacttg ccaggaggaa
    12061 cggccccgcc ttccggagcg atatcaccag gaatccctgc aacgcgtttg atcagccatt
    12121 gatcgcttga cacgccggag aaccgggaac caattccgcg agctcgccca ttccggaggt
    12181 ctccgcctcg gccaggccgt ttcacaacaa tgatctctcc acgcgtcggc cttcttctcc
    12241 gccgtacgag tacccgatcg ccgggcttgt aggtaggcaa catgctcagt cccgtgacgg
    12301 tcacgatgac caggctgctt cgcaccattt tgtatgagat cagagccact gccatgacag
    12361 ccgcaaagag cccgatgagg caccacccaa gagtggtcat cggcctgcct gcccaagcgg
    12421 aacagaatcg gcttcttctt ggtaaccgga tgcctgaaga gcgaacagtc gagcgtaatc
    12481 gccttcgtgt gccatcagtt ctgaatgggc tccctgctcc acgatccttc cgttcgagag
    12541 cacgacgata tggtccgcgt ttcggatcga tccgagtctg tgcgagatca gaaatgtggt
    12601 cagcccgtcg cggtgtcgac ggagcgacga gttgatctcg tgctcggctt ccgcgtcaag
    12661 attggaggcc ggttcgtcca gtatcacgaa gtcacgtcga ccgcgcagga atgctcgggc
    12721 cagcgccaga cgctgggcct gcccgccgga gagcacgatt cccgtctcct cgttgtcctt
    12781 gtcggcttcc attaagaaga tcctggtaag gagcgtttcg taccccttgg gcaaggaagc
    12841 gatcacatca tggattcccg cgttcaccgc cgcttcctcg atcagaggag aatcgtcgat
    12901 agcccgcaga tcgcccaggc cgatgttctc gtgagccgtc atatcgtaat gcatatgatc
    12961 ctggaaaact gcacccatgc gcgctctcat ctgtgctgcg tcgacctctc gcagatcaat
    13021 tccgtcccac aaaatggcgc cgcgcgtcgg atcatagaac cggcatagca gcttgaccag
    13081 ggtcgacttc ccggcgccat tgaggcccac gagtgccagc gacttaccct gcgagatagt
    13141 gaggtttact ccgcgcagga tccacgggtg gtcgtcggaa taccggaacc atacatcgcg
    13201 caattcgata gcgtgacgaa gtggtgggat ttccagcggg tctcgaggta cggggagatc
    13261 agaaggcgct tttgtcacag cgaggtagtg ctcaaagagt gaaagtgctt ggtggaccct
    13321 tgccgagtcg accgccagct gggtcaacgc cccttgaatt ccggcaacgg ccgcgatgaa
    13381 gatggcgata tctccgaccg aaagctctcc ggctgatact gacttcactg cccacagcag
    13441 gccggctccc gacaggattg tcgccaggag cgtcagggtt gactggacga gcacctgatg
    13501 ccggtcggca cgtcgcttgg ccgagttgct ggcccgtcgt tccttctgca ttcggccgag
    13561 cagaaagtcg cccagcccga acaggcgcac ctcctttgct gcctcttcac tggacaggag
    13621 ctggtcgtag aacatctctc gccgctccgt gggtccgatc tgccacagca tcttggctcg
    13681 gactctggac agggctatct cagcaaccag taccggaata ccgaaggcca atatgaagca
    13741 ggccatgagc ggagccaaga tgaagagaga ccccacgaac cccgtgatcg tgatgagcga
    13801 gcgtacggtt cccagccctc cgtcaaggac ctgatggggg ccgtcctgcc cagatctctt
    13861 tgcgagccgc atcctgtcca agtagttcgg gctctcgaac ggcgccagcc cgatgaaccg
    13921 gttcaccgcg gtgaagaggc tctcctgagc gatcagcccg atctctctgc cgagttcagc
    13981 gccaaggaac ctcgagacga tcggcgcaat cccctgcagc agacctgcga cggcgagagc
    14041 cgacccaaga gtgatggctc tttccaaaga cacgccatcg accaggccgt ccacgatcag
    14101 cttggtcagc catccgatgg cgaccgggag agagccgctc gccaaagcca gaacgacata
    14161 cgcgaagacc agcagaggcg atgcgcgaaa ggcgaggcca agcgcggcca cggcagcgcg
    14221 agcagggaat attttggggg aatcgttctc ttccacgatc actcctcctg agccgtcttc
    14281 tccgtcagct gaccctgacg ggtgagacag gggtttcatc tcccgtcaaa cgagcggaac
    14341 tctgcacgga ataggacacg tttccagatc catcgatgac tgaatacgtc ggccatacgg
    14401 tcacccccat ctctctgacc actcgatcca ccgattcacc cgagtgaact actcgactga
    14461 catccctgag ctcatctgca taaagggaaa ccccttcctc gtccccgagg atcagggaaa
    14521 agactcggtc gcgcgcaatc ccggaggttt ccaggaactt cttgtactcg ggaagctgtt
    14581 gcttgcagcc gctacatccc gtggactgga aggtcagaat ccactgcgca ccgtcctggg
    14641 ccgggaactc cacgcgctcg ccgtgtacgt ctgtcatcgc accgacgccg ggaacgggtg
    14701 ttcccagcgg aattcccctt ggccgtcggc ccgtgcccac ccctccctct tcgaccaaag
    14761 ggtcaaggag tctcttcact ctcagcgcaa cggccaagga caacgcacac ccagcggaag
    14821 cgacgagcag ggccagcacg gaaaacagga tcgccacaat ggaattcctt ttcagtcacg
    14881 ttgccatttt gaagaacgac actatttcat ccagatagag caggagagcg ccggctatta
    14941 ctgcggggcc gagggagaag tagaacgcga aagctggcgt gtcccccata ccagtggcca
    15001 ggagcgcacc tgctccggaa accatgacca acaggatgtt gcgggtcacg tgtacgccgg
    15061 agattggccc cccgccgtcc cccacacacc cgcaggatgc gccccttcgg gtcctgagca
    15121 tggccaccag atacaaagtg aagccggcca gcaggagcac ggacagggag aacccgatcc
    15181 atgccgggcg gatcaccatc agggcaagtg ccgtgccgat ctcagtcgct acgacgccgg
    15241 cagccaagaa gctcgcaaaa ggacgtacgc ctggcatggt ggaaatcaag tgggcccgga
    15301 aggcggaaag ctcacgcaac ttcagaatag ccgacaaaag atatacagtc gccatcaata
    15361 tctgacagaa tatgaccatg gtgctcaatt ggacccctgc ccctgtactc atcgcaccga
    15421 tgtctgtgcg tgcgccgctt ggcactggcc aagagctgtt ccgatgacaa gcgcccatat
    15481 ctgaccggga tgattcaggc cctggtaacc accgaaggaa aggcggtggt taccagggtg
    15541 cagtccgacc gccccttatt ccgcagccgg ggaaatcccc gtcctgccgg acagtaggac
    15601 gtctcgtatc gcggccgtct acgccaggat cttcaccgaa gaacccctgg cagggtaggg
    15661 aaccgggatc agccgatgtt cacacaattg gcagtgcagt tggcgtagaa gcagcacttc
    15721 cgccagaccg tacccgtcca ccaggtctcg cagtactccg ggcagccggc cgcggcttcg
    15781 gtcttgggaa gcagcctgtc ggccaccttc atgacgagat tggtgatcgc cttggacatc
    15841 ttctttcctt tcgtagacgt atgccgggtt cggcatcccc ctgcgccgtt ccttctgcgc
    15901 ctcttcagga ttccgcggaa acctttcagg gatctttcac gagctcagag cgatacgtga
    15961 tctctgttcg gcctgtatga ctcgatggtg tgacggtggg acataaccgc cggtcagaca
    16021 ttgacgattc gcttaaccgt gattcaccgg atggtccggt tccggtcggc cccttgcggg
    16081 cgggcagggt ctgctcgggt cagccgaccg tgacacgggc gatgtcgaag gcgtgtgtcc
    16141 aggccgaccg ccagggccgg ctgttcggca ggtacagagt gacgcggcgg gcagtgcggg
    16201 cgggccggga tctggatcag gggagtacaa aacgtggcgg tggtggccct ggcgtcgaaa
    16261 gcggaggtga gcgtgtctgt gcccgcgggg tgcccacatc ggcgaggcag tcccgcccca
    16321 ggcgaccgcg agcgcggaga agaccactcc gcgaccgcca ttcccaacgt gaacacgcgg
    16381 gtacgcccca cctcgcgcaa gcccgaggct caggggcgag ccgaagcctc cgtgaccgcg
    16441 atcggaaaga ggggccgaca gtggcttgag agccctgcac ctgagtgccc cctacgcctc
    16501 gtctacagtc atgggcatga ccgtggacga ggttcgcttc cgggttttgg gccccctgga
    16561 ggtcgaaatt ggacgccagc ccgtcgcgct caccggcagg caacgcgggc tgctggcagc
    16621 gctgctgctc agccctaatc aagtggtctc ggtggcgtgt tgcgcagacc ggctctgggg
    16681 ggaaagagcc ccctccaccg cccccgcccg cgtacgggcg ttggtcacgg aattgcgccg
    16741 cgccctgcat attgaagggc gtcggctgat cgtcacccgc agccccggtt actcgattct
    16801 tctccaggac gacgaactgg acgtcgtcga attcgcgtgt ctgctcgatg aggccggccg
    16861 gtccgcacag cgcaagcggt tctcgcaggc gattgatcag tacgacgggg ccctcgctct
    16921 gtggcggggc gatcccttcg tcgatctcga ggcgatggaa gtcggagtgg aggcgcgtag
    16981 gctcggggag gctcgggccc tggcgatcgt gagccgtgcc gagtgccacc tgtcttcggg
    17041 gcgcgcggcc gaggccatcg aggacctgat ggccttcacc gccgagcagc cgctgcgtga
    17101 accgccgcgg ggccagctga tgcgagccct cggtcactcc ggccgccgct ccgaggctct
    17161 cgaggtgtac gaggactatc ggatcgtgct gcaagaagag ttgggcgtgg agccgtccga
    17221 tgagctccgg cgcctgcgcc tcagcatgat cgagggaggt ggggttccga cgggaggcgt
    17281 gtccaccgtg cctgtcgcca taggaccccg acgacctgtg gggccgcgtc agcttcctcc
    17341 gcgtacaccc aggttcaccg gtcggcgaga agagctgcgg cgcctcgacg agatgcacgc
    17401 ggacagagag ccgaccgtcc tcctggtggg gggcgccgga gtgggcaaga cgtccctggc
    17461 cctccattgg gcagaccgag tcgccgcccg ttttccggac ggccagtttt acctgaatat
    17521 gaggggcttc gaccggtcgg agccgatgcc tgtcaccgag gccctgccca tcctgctcca
    17581 gggcctgggc tggtccgcca gggatgtgcc ggtcgacccg ggggctcagg tggccctcta
    17641 ccgctcactg ctgtccagtc ggcgcacctt gctggtgttc gacaacgttg cggatgtaag
    17701 gcaggtgcga gaactcctgc ccggtggctc ccattgcatg tcggtcgtca ccagccggga
    17761 ccgcttggaa ggcctggtgg cgttggacgg ggcccggcga cttaccctga acgttttcga
    17821 cggtgaggag gctctgggcc tgctccggcg aggcctgggc gagaacagga cacagcggga
    17881 acccgaagcc gccgcggagc tggtcgaatt gtgtgaccgc ctaccgctcg ccctgtccat
    17941 tgctacggcc tggattgcgg accaggagca caggaccatc ggtcagtaca tagcgcggct
    18001 aacgcggcaa gggcgtctgg ctcagttgaa ggtggagggt gacgaatacg ccgccgtacg
    18061 agcagcactg gatttgtcct acgaggcgtt gcccgtcacg gcacagcgtg cgtttcgcct
    18121 gctgggcgtg gtccctcatg cgggcgtgtc cgcgcgtgcg gccgccgccc agatcgattc
    18181 cgcccccgac acggctgacg atcttctgtc cgccatagcc cgcgtgcacc tgatgagcga
    18241 gtcgggggtt cagcgctatt cctggcacga cctggtgaag gagtacgcgg cggaacgcgc
    18301 tgccgtagaa gatccacccg aacagaggga ggccgctgtc cgccgtctcc tggcccacta
    18361 cttcctctcg gttatcgacc tcgtggacgt atgcgggtac cagcctccca gcatgccgta
    18421 cgacgtggac gaggtgccct gcgctgggcc aagtgttttc gacggcccgg aggaggggct
    18481 ggcttggttc gacgcggagt ggaagaatat tcttctggcc atcacctacg cagcggaaca
    18541 cggtccgccg ggctatgcgc cgctcatcgt cgacgccctg caggatctgc tccagcacca
    18601 tcgtccttat acggaatggc tgcgcatctc cgccaccgcg atggctgcgg cccagcgcca
    18661 gtccgacatg gccggtcagg cggccatgca cctctcccaa ggtctcgcgc tcctccgcat
    18721 ggcggatctc gaggcgtcgc tggcacagaa caaggcgggc ctggagctct cgcgccgggt
    18781 gggctggcgc gccggggagg caaacgccct ccaggggtgc ggagtggcgc tcaagcagct
    18841 gggcgaggca gagcaggccc tgctgatgta ccgccaggcg caagagatca accacgacct
    18901 gaggctgcta cggggtgagg ctcggtgtct cagtgagtgt ttggattctt ggcccgttga
    18961 tgccttctcg actattggcg ggcggggtca gcccaacggc tgagtgcgtg ttctccagtc
    19021 cctgttgatg cggtccagcc acgtgtcctg gtcgtctgcc aaggggagtt gtagcgggat
    19081 cggcaggaag cgacaggaga agatcatgct ggcgtcactg ccgtcactga ggacgcgatg
    19141 gacccatgcg tcgggggtgt ccgcggaggc ttggaggtga aagaagttcg tgcgccgtgg
    19201 gtgcccggtc tgtggatgcg gcttgtcctc gaccgcaagc tgcccgatga tgcgagcggt
    19261 ctgcaggccg gtttcttctg gcgtttctcg cagaaccgct tcttccaggc tctccccggg
    19321 ttggacacca cccgcaggga tctgggtgcc agcttcggga tagtcgacat ggtcgaagac
    19381 cagcagctca ggaacgtctt gttggcggat cacataagca gcgacgcgga ctctcggatg
    19441 gctcaccctc acagcctccg tcactatgcc gtgtgatcgc ctgcctcctc tatgcgctca
    19501 agatcaggcc cctctggtcc agtccgcgcg gggtccactg cgggtgagcc gtctggtcat
    19561 gagggtgatg agtgcccagg tcagatgagc ttcggagtgt tggggctggc gttcgtcgtc
    19621 gcggacgttg cggcgggatt tcatgatcca gccgagggtg cgttcaacct tccagcggcg
    19681 gggcaggatg acgaagcctt tcgcgccgcg ggggacacgg tcttgagagt catgttgagg
    19741 aagtcgcagg tccagttcac gagccgtccg gcgtaggcgg agtcggccca gacctgggtg
    19801 attcggggtt gcatgacccg taggcgccac aggagttctc gggcggcgtc gcggtcggtg
    19861 gtgtcggcgg gagtcaccgt gatcatcacg ggcaggccga gggtgtcgac ggcgatgtgt
    19921 ctcttgcgtc cgttgatctt ctttccggcg tcgaagccgc gggtggcctt ggagacggtt
    19981 tcggcgccct tcacggactg tgagtcgacg atcagtgtga cgggccaggg gtatcgcccc
    20041 tggtccgtgc ggatctggcg gcgtagctgg tcgcgcagga aggcgatgac tccgggccca
    20101 ttcggcgacg gtggtgtcgg agggatagcg gcggcgacgc gaggagggcg gcatgacggt
    20161 ctcggggagt tggctggttg cgaaagaccc agcggctgct cgcctgagca ctgaggaagg
    20221 accagtgcgc cgtcggcgag gtgcggcccc tgctcgcgga gcgaggatgc acggtcaacc
    20281 ccgaggagcg gctgcggact cttgccgagg tcgtcagcgc tccgaccgca aacgatcacc
    20341 gggcagtggt gccggccggc cctgcaccag ttggatgtga cgacacgtcc gttcggtgcc
    20401 aggaggggcg acggcagggc cggtcagggt ccgcggactg actgatcagg aggggcggaa
    20461 gccgcagcgg atcgtacggc ggggcagcac cagcacggtg cggggcggcg gttccgcagg
    20521 gcgatgacgg tgccggcctc cgcaggtggg aacagcgtcc cggtgatcgc gcatctcgtg
    20581 cgggcagacg aggacgccgt ccgtgacgtc atccaccgct tcaacgagat cggcctggcc
    20641 tgcctgggag gccctccgct gcctgctcgg gcaccgcggc gtgacgttac gccggaccaa
    20701 gacacggcac gcggcggaca ctg
//
