LOCUS       NZ_KB890915            20294 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptomyces sp. CcalMP-8W B053DRAFT_scaffold_0.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KB890915
VERSION     NZ_KB890915.1
KEYWORDS    WGS; GSC:MIGS:2.1; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces sp. CcalMP-8W
  ORGANISM  Streptomyces sp. CcalMP-8W
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 859314)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
REFERENCE   2  (bases 1 to 859314)
  AUTHORS   Currie,C., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptomyces sp. CcalMP-8W
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: Missing
            num_replicons                     :: Missing
            ref_biomaterial                   :: Missing
            biotic_relationship               :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            assembly :: Velvet v. 1.1.04; ALLPATHS v. r41043
            finishing_strategy                :: Missing
            environment                       :: Missing
            trophic_level                     :: Missing
            sequencing_meth                   :: WGS
            Funding Program                   :: DOE-GLBRC 2011
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. r41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 03:14:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,603
            CDSs (total)                      :: 6,529
            Genes (coding)                    :: 6,424
            CDSs (with protein)               :: 6,424
            Genes (RNA)                       :: 74
            rRNAs                             :: 6, 1 (5S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 105
            CDSs (without protein)            :: 105
            Pseudo Genes (ambiguous residues) :: 0 of 105
            Pseudo Genes (frameshifted)       :: 35 of 105
            Pseudo Genes (incomplete)         :: 83 of 105
            Pseudo Genes (internal stop)      :: 5 of 105
            Pseudo Genes (multiple problems)  :: 18 of 105
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:04:40
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 503650
            Orig. end                         :: 523944
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB890915.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 405361
            Source DNA and Organism available from Cameron  Currie
            (currie@bact.wisc.edu)
            Source DNA available from Cameron  Currie (currie@bact.wisc.edu)
            Organism available from Cameron  Currie (currie@bact.wisc.edu)
            Contacts: Cameron  Currie (currie@bact.wisc.edu)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20294
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20294
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20294
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10294](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10294
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(287..297)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(339..770)
                     /locus_tag="B053_RS0102185"
     CDS             complement(339..770)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449417.1"
                     /locus_tag="B053_RS0102185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_018486971.1"
                     /transl_table=11
                     /translation="MDRLDREILGILQEDARISYRDLGVRVGLSANAAGDRVRRMRKDG
                     VIRGFTVIIDPAADTRSGLVVFIDVTLRLDTTNEEFERSVLMLPGITEVVHVTGGHDYL
                     IRATAADPVALDSLLRRLKREAGVAHSTTRIALRAAPKH"
     gene            954..2189
                     /locus_tag="B053_RS0102190"
     CDS             954..2189
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761519.1"
                     /locus_tag="B053_RS0102190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NarK/NasA family nitrate transporter"
                     /protein_id="WP_018486972.1"
                     /transl_table=11
                     /translation="MNSAIKQSPEPPDAPAPAAAAAPSAAAYRNLVMATIGFALTFWAW
                     NLIAPMSGDYKDRLGLSSFQQSFLVAVPVLVGSLGRIPVGALTDKYGAKLMFPLVSALT
                     IVPVLLLIPAKDSYGAMIAVGFLLGLGGTTFAIGVPLVNSWFPPAKRGSALGVFGMGMG
                     GVALSGYFTPRIAKHGDNLPFLVVAGALVVFALLAAVLVSDHPGRKIPTDTLVHRLGEA
                     GKLRVTWELSALYAIGFGGIVAFGVYLPTYLKTWYEMSPTEAGTKAAGFALVTVVFRPI
                     GGWLSDRVHPALVTAGALLLAALMAVVQAFEPPLNPTGTIALLAMAAGLGTASGSVFAL
                     VSQVTPQAKVGSVTGIVGAMGGLGGFVPPLVMGAIYSAKDSYAIGFMLLSDLALAGCVY
                     AYARMRNLRRGG"
     misc_feature    2834..2849
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    2836..2850
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.02"
                     /tool="antismash"
     gene            2989..4629
                     /locus_tag="B053_RS0102195"
     CDS             2989..4629
                     /NRPS_PKS="Domain: AMP-binding (16-451). E-value: 1.3e-84.
                     Score: 276.1. Matches aSDomain:
                     nrpspksdomains_B053_RS0102195_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006124235.1"
                     /locus_tag="B053_RS0102195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_018486973.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-92, bitscore:
                     305.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLLPALQSPTGPAASREAVRFGDLSLSYGRLAEASAALAARIA
                     DAGRVAVWATPTAETVIAVVAALRAGVPVVPLNPRTGERELAHILADSEPTAVLAGPAD
                     ELPPALEKVPRMTVDARAETAGATAYGEGGGGAAAYAEGRGGATAHAEGQGGAAAHAEG
                     GGGATAYGYSGGGAPAGGGAPGPGAGDPESPALIVYTSGTTGPPKGAVLPRRAVAASLD
                     ALEDAWGWTGDDVLVHALPLFHVHGLILGVLGPLRRGGSLRHLGAFSAGGVARELGSGG
                     TMLFGVPTMYHRLAEVLDAPAGTAERDALAGALAGARLLVSGSAALPVHDHERIAAATG
                     RRVIERYGMTETLMNTGIRADGVPRPGTVGPPLAGVELRLVEEDGTVLEGPEAIGEIQV
                     RGPNLFTGYLNRPDATAAAHTADGWFRTGDVGTVDTDGYVTIVGRKATDLIKSGGYKIG
                     AGEIENVLLGHPGVREAAVTGEADPDLGERVVAWVVAADPDAPPAAEELADLVAGQLAP
                     HKRPRTVRYLDALPRNDLGKIMKRSLHVR"
     aSDomain        3037..4341
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B053_RS0102195_AMP-binding.1"
                     /evalue="1.30E-84"
                     /label="B053_RS0102195_AMP-binding.1"
                     /locus_tag="B053_RS0102195"
                     /protein_end="451"
                     /protein_start="16"
                     /score="276.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SREAVRFGDLSLSYGRLAEASAALAARIADAGRVAVWATPTAETV
                     IAVVAALRAGVPVVPLNPRTGERELAHILADSEPTAVLAGPADELPPALEKVPRMTVDA
                     RAETAGATAYGEGGGGAAAYAEGRGGATAHAEGQGGAAAHAEGGGGATAYGYSGGGAPA
                     GGGAPGPGAGDPESPALIVYTSGTTGPPKGAVLPRRAVAASLDALEDAWGWTGDDVLVH
                     ALPLFHVHGLILGVLGPLRRGGSLRHLGAFSAGGVARELGSGGTMLFGVPTMYHRLAEV
                     LDAPAGTAERDALAGALAGARLLVSGSAALPVHDHERIAAATGRRVIERYGMTETLMNT
                     GIRADGVPRPGTVGPPLAGVELRLVEEDGTVLEGPEAIGEIQVRGPNLFTGYLNRPDAT
                     AAAHTADGWFRTGDVGTVDTDGYVTIVGRKATDLIK"
     CDS_motif       3571..3624
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B053_RS0102195_0001"
                     /evalue="2.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="B053_RS0102195"
                     /protein_end="212"
                     /protein_start="194"
                     /score="19.9"
                     /tool="antismash"
                     /translation="ALIVYTSGTTGPPKGAVL"
     CDS_motif       4162..4242
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B053_RS0102195_0002"
                     /evalue="2.70E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="B053_RS0102195"
                     /protein_end="418"
                     /protein_start="391"
                     /score="29.3"
                     /tool="antismash"
                     /translation="EAIGEIQVRGPNLFTGYLNRPDATAAA"
     gene            4619..6112
                     /locus_tag="B053_RS0102200"
     CDS             4619..6112
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007449426.1"
                     /locus_tag="B053_RS0102200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carboxyl transferase domain-containing protein"
                     /protein_id="WP_018486974.1"
                     /transl_table=11
                     /translation="MSGDAPLAGGSPESGGYPASGGSPLAGGSPGSGDDPAGAPSGATP
                     RATAREAIALLTGGAGFTEHRPPSPRTLPPDGPLGWAGYDMARARAAERTGEDESVVYG
                     TGVAGGRECVLLAFEFGFLGGSLGLLTGDRLEAAYDLALARRLPLVALVATGGSRMQEG
                     MVALTQLQRVAAASTRLRAAGLPQIAVVRDPTTGGGWATVGAGADVVLALPGAQIGFAG
                     SRVRPPDADPYAYGAEGQSAAGQVDAVVPGPELPRTVGLWLRALGAGEEAAGTGDGPAA
                     APLPRAQAPSAAGLPGSGREAVERARAAGRPRARAYLDDYFAVRLPLHGDRSGGTDPGL
                     LSGFGLRADGRAVAYVAQCGTPTRPAGYRAAARTIRLADRLGVPVLTLVDTPGAANDAE
                     AERAGQGAAIADTFAAIAAARVPVTTLVIGEGGSGGALALAAPGNTHVTADSYFSVIAP
                     ELAAAILKRPPEETGATADQLRLRPQDLVELGIARSVVR"
     gene            complement(6143..7411)
                     /locus_tag="B053_RS0102205"
     CDS             complement(6143..7411)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010064356.1"
                     /locus_tag="B053_RS0102205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_018486975.1"
                     /transl_table=11
                     /translation="MTDTTEQPARRPRIFADLTPLRAYPDYRRLWFGNTVSWIGQGMTA
                     LAVSLQVYDITGSAFSVGLIGFCSLVPLVVFGLYGGAVADTVDRRKLGLFSAAGSFLLA
                     LVLALATFAGAENVGLLYAIVALQAVCFALNAPARSSMIARLLPPEQLPAANALSSMTT
                     TTGALVGPMLGGLIVGWWGYRAAYTVDAVTFTASLYAMWRLPSMLPDRTAEGEVRKRAS
                     VTDGLRFLGTRPNLRMTFFTDLCAMVLAHPRALFPVVAVVWYGGDARTTGMLVAAPALG
                     ALLGGVFSGWLGRIRRHGLAVLLAVGSWGAAIAVFGLTRHLWLGLLFLALAGCADTISM
                     VFRNTMLQAAVPDEMRGRLQGVFIVVVAGGPRLGDFLAGSVADLTSPAVAVVGGGAACV
                     VAVGLLALKWRGFARYDARDPQP"
     gene            7591..9423
                     /locus_tag="B053_RS0102210"
     CDS             7591..9423
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021507.4"
                     /locus_tag="B053_RS0102210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphodiester glycosidase family protein"
                     /protein_id="WP_018486976.1"
                     /transl_table=11
                     /translation="MPARSAFLARSAGSARSAHSAGFVRRVRVPAAVAVASVLLLGAAA
                     PGQQPRTGGAVAGTEPVGRMPLGPADVPTQTRPADLLAPGVTYRKYWQGEASDAWSVWV
                     RHPQAGTETFGSWADADRLARDLDAAGFTARVDVFTVPESVDTDSRVVGYGVRVGRFAA
                     DRREDAVQARQALADAGFGRSRIFFTAEDGSASRGPWQVRVITVAPSARVTLKAVHGKD
                     VQGSETVRQLAAESGALVAVNGSEFDIDSPNNGDFGGFEGVPQGLYLQNNVLLGTPNNG
                     RTALLLEGLQGRAAVDEISSETRITAPDGAVRVVDGIHRPAGHVLGCGGVGNDYRASDR
                     TRTLQPRRNTTCHDPDEIVVFRPEWGATTPTPVRRGDSWTDPVTGWQAQWYADRAEFLA
                     HTVDVVMDGNWVVKQLRTPAGGPIPPGGRVLQGIGEGAAWLRAHSEVGKAFKPGSTVRG
                     RDGRSVTTPALSAVAGGTPALVRGGEVWLNPAANGMAQASCVPADLAPGQKCRANNTLL
                     QRHARTLAGVTAAGELLLVTIDGRDPALSVGATLPEAAAVMKWLGAREAVGLGSGGDTT
                     LIAGNTLYNRPVDDWGGPLRERRVSNAVVVVEKP"
     misc_feature    9919..9934
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.66"
                     /tool="antismash"
     gene            10001..10294
                     /locus_tag="B053_RS01000000133310"
     CDS             10001..10294
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.4"
                     /locus_tag="B053_RS01000000133310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PqqD family protein"
                     /protein_id="WP_018486977.1"
                     /sec_met_domain="PqqD_RRE (E-value: 6.9e-10, bitscore:
                     34.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.2e-13, bitscore: 45.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.8e-09,
                     bitscore: 31.4, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGETEIELTPASVLQRRVEARARRYRGRMYVAVREHALELDEVAQ
                     AIVRRIDGTSTLRGIAAVVAEEYGVPAENATGDTVEFAAQLLAHGVVEVVPG"
     aSDomain        10034..10279
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B053_RS01000000133310_PqqD_RRE.1"
                     /evalue="2.70E-11"
                     /identifier="RREFam006.1"
                     /label="B053_RS01000000133310"
                     /locus_tag="B053_RS01000000133310"
                     /protein_end="93"
                     /protein_start="11"
                     /score="34.1"
                     /tool="antismash"
                     /translation="SVLQRRVEARARRYRGRMYVAVREHALELDEVAQAIVRRIDGTST
                     LRGIAAVVAEEYGVPAENATGDTVEFAAQLLAHGVVE"
     aSDomain        10115..10282
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B053_RS01000000133310_Stand_Alone_Las
                     so_RRE.1"
                     /evalue="2.30E-10"
                     /identifier="RREFam002.1"
                     /label="B053_RS01000000133310"
                     /locus_tag="B053_RS01000000133310"
                     /protein_end="94"
                     /protein_start="38"
                     /score="31.4"
                     /tool="antismash"
                     /translation="ELDEVAQAIVRRIDGTSTLRGIAAVVAEEYGVPAENATGDTVEFA
                     AQLLAHGVVEV"
     gene            10488..11264
                     /locus_tag="B053_RS0102220"
     CDS             10488..11264
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016579313.1"
                     /locus_tag="B053_RS0102220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_018486978.1"
                     /transl_table=11
                     /translation="MVESVKRAVRIIKELTGSSPRLGVTELADRVGVSKSAMHGLLRTL
                     ESDGLVVQDQESGKYRLGPALVTFGNAYLDTHELRTRALTWSNLLATRTDEAVWVGVLV
                     HDDVLVIHHVCRPGNVAQPLETGATLPWNTTALGKAIVAFSPEELRTRLLSRPPAALTG
                     HSVTEPELLEAQLAQAREVGYAVEKQEATLGDAGIAAPIFDRTGCAAGAIGLVGPVERL
                     LDERHRQGCSIATRETARSLSRELGAHRFGNRVASF"
     misc_feature    complement(11599..11615)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    11610..11623
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.44"
                     /tool="antismash"
     gene            12029..12607
                     /locus_tag="B053_RS1000000135005"
     CDS             12029..12607
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1097: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024736.4"
                     /locus_tag="B053_RS1000000135005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transposase"
                     /protein_id="WP_078507600.1"
                     /transl_table=11
                     /translation="MTHQGNPLPPLRRTNSTLPEARVPGPRVPLPGAGRFTWLAPMALW
                     PLARRHLPRPAVRPQGGGSQRADDEATFAAILFVLVSGVPWRALPRAFTVSWQNTHRRF
                     TQWSAAGLWDQLRESAHRQHAPGQSRELVQWAEAVCELAEERLNRTAPPSAGPAAARRR
                     AGSLQPRLRVREPDDFTVRLFGPGRDSAW"
     misc_feature    12050..12052
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12601..13401
                     /locus_tag="B053_RS0102230"
     CDS             12601..13401
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B053_RS0102230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_018486980.1"
                     /transl_table=11
                     /translation="MVTPAGSAGLTGCLEEMDRRGLIPDGCLAVCCVGPAARGWADEGG
                     TYDFHVVSTGPWTGEGARALPVRLSPAEVPSLALSVAGRRWEITYWLEGQVRQVLAKVT
                     RERFEGGGTAVGVLTDAEELFLERMSAPLALSGTEWAKECERRIGGSAFRAFVTTRSLA
                     AADRAIEDAGRRLAARDVPSAVLSARSALGHTVDALLESESDFGSRAPRRRARRLRETR
                     PRALPFAEYWAMETMRSYDPARPEEWVTTVVQRCRDLAFEVEIS"
     gene            complement(13444..14748)
                     /locus_tag="B053_RS01000000133320"
     CDS             complement(13444..14748)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="B053_RS01000000133320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_018486981.1"
                     /transl_table=11
                     /translation="MIRGTFRTVAGLNSDLRALFVSTLLFRAGTMAFPFLGAYLLGQER
                     YGVEQVGLVVGAFGLGALVADVGAGVLLGRLRPVTVMLGGCVGYALVLAVVPALSAVPA
                     LLVATLLWGMAFEIYTPASYAQVVAGSSAEQRKIAFSCNRLAINLGMGLGPAVGGLLFT
                     VAPQALFYVNAVCVLAAAGVLLRRSASTRSATTAEAPGPGRLLSPTARDESRFWTLFVL
                     ALPVHIAYALPPILLSTYIIEGIGLPAYWVSVVFVVNAAAIVLFEVPLNKAMVHMSHLR
                     SLLIGYVLAAAGFALTGLTSSGPLLAVIALLWTCGEMIVFPALLSYVSQLSAPTVINRN
                     VSLYSAGVNVGFMTAPQIGGVLSAGRSPGTPWLAAGTALAAASVLMVAARFSRATWCPD
                     DEHPGADDGPEEQAADGTPKDGQADRAPQSADSTG"
     gene            complement(14745..16043)
                     /locus_tag="B053_RS0102240"
     CDS             complement(14745..16043)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037399.1"
                     /locus_tag="B053_RS0102240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_018486982.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3e-07, bitscore:
                     26.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 1.3e-09, bitscore:
                     33.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDLARAHANGDRYLLLLGSDILLRERGVVSALRTYPGPVIGMSE
                     TPAAQNANRFFDHVLRADYYDERQALEAVQQFERETGLRPGAVVPIIEMTVHVSVAVAR
                     HYDLPRLSDACLAKVRDKHTMKAAFEAAGVPCARHRLFGTLEELHQAARELDFPLVLKP
                     RDFAGNVGTVRVNGPGELDEAYVYCRDSLLEIAPLYGFEDGRFQAEEFVTSTHEVSVEV
                     ANHRGERTVVAVTDKSKAGAPYFSERGQLVPSADSGNEELRRVALAACAALDIDHGLAH
                     VEVLVDGDRLSVVEVAARPGGDGIMDLIDRVYGFSPYDLHFGSYTDTLDGLPAITAEPA
                     GMGATAFLKAPPGTITEVKPVHDLTPEEVGLYITAQVGDVSRPLTSYLARDGVLECFER
                     GQSDQRAFRAKADELARQRTEQIFTVEAEHDPS"
     misc_feature    16055..16064
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.4"
                     /tool="antismash"
     misc_feature    complement(16055..16069)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.85"
                     /tool="antismash"
     misc_feature    16056..16069
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.09"
                     /tool="antismash"
     gene            complement(16431..17900)
                     /gene="ahcY"
                     /locus_tag="B053_RS0102245"
     CDS             complement(16431..17900)
                     /EC_number="3.13.2.1"
                     /GO_function="GO:0004013 - adenosylhomocysteinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ahcY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018386384.1"
                     /locus_tag="B053_RS0102245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosylhomocysteinase"
                     /protein_id="WP_050565921.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.9e-08, bitscore:
                     28.3, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVALTADSAGSVGGFKVADLSLAELGRKEIRLAEHEMPGLMALR
                     QEFGPQQPLAGKRIAGSLHMTIQTAVLIETLAALGADVRWASCNIFSTQDQAAAAVVVG
                     TEGTVEEPKGSAVFAWKGETLEEYWWCLEQLLTWPDGSGPHSIVDDGGDATLLVHLGAE
                     YETAGAVPDALADDPEEHRIILDVLRRSLVDNPGKYSEMAKFIVGVTEETTNGVNRLYR
                     LGKEGKLLFTGINVNDAVTKSKFDNRYGIRHSLVDGINRAIDVMIAGKLAVICGYGDVG
                     KGAVASLRGQGARVVVTEADPICALQAAMDGLKVVTLDQVVETGDIFITTTGNRDIIMA
                     DHMARMKHNAVVGNVGHFDNEIDMAGLAQVPGIEKTEIKPQVHEWAFPDGHSIIVLSEG
                     RLLNLGNATGHPSFVMSCSFANQTLAQISLFDPAQNYGTDVYTLPKHLDEKVARLHLPA
                     LDAHLTELTKVQAEYIGVDIEGPFKPDHYRY"
     misc_feature    complement(17919..17933)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            complement(18024..18701)
                     /locus_tag="B053_RS01000000133325"
     CDS             complement(18024..18701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090015.1"
                     /locus_tag="B053_RS01000000133325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RraA family protein"
                     /protein_id="WP_106669296.1"
                     /transl_table=11
                     /translation="MPTQPTRSTEPPSAPPGVDALRELLLPEYSPSCLAADAGDRIGAI
                     GGLLTVNPAHRVVGPALTIDLSEQDLVDILPVLGQARPGDVIVLACHGITGMAMWGGLM
                     TTLSQVAGIAGAVVDGAVRDVDEIRDLGLPVWYRTAQPRRCPPADLDGVVQVNVPVTID
                     GVTVRAGDIVVADENGVAVVPPDAAEEVAASTRELLAKERIVRDLMNAGATLPELLARF
                     GHL"
     gene            complement(18804..20096)
                     /locus_tag="B053_RS0102255"
     CDS             complement(18804..20096)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (60-416). E-value:
                     1.6e-35. Score: 114.8. Matches aSDomain:
                     nrpspksdomains_B053_RS0102255_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012382.4"
                     /locus_tag="B053_RS0102255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_018486985.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.7e-34, bitscore:
                     115.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADPGPAALDLADLGPAAQSPGVPGPGVPSWDRLFARHVASDTG
                     DQITAILDQSGATDAIALSGGFPHPDTFPARALAESHARVLAQPAALQYGPTPGLPGLR
                     DWFTGWLGRAEGRTPADGELLITSGGMEGLGLITRSLLDPGDRAVVEGPTFFGALVGFQ
                     RQLARVETVPVDGDGLDTDALAELLRGTTGPAPKLLYLVPDHQNPTGLTLSLERRHALI
                     ALARRYGFLVVEDVAYRELGFDGERHPSLWALAPDVVAQVGTFAKTFTPGIRLGWVVAP
                     ARLTAQLARAKQNTDQCTGAYGQLLLEDYGRSGGFDRQIAASRAFYRRRRDVMTDALAA
                     HLPEEVAYTRPHGGFFSWLTLPGDVDTVALQERALAAKVSYVPGRAFYAGEQGGNSLRL
                     AFSRVPDEQIAEGVRHLSGVLAEAIGATTTR"
     aSDomain        complement(18849..19916)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B053_RS0102255_Aminotran_1_2.1"
                     /evalue="1.60E-35"
                     /label="B053_RS0102255_Aminotran_1_2.1"
                     /locus_tag="B053_RS0102255"
                     /protein_end="416"
                     /protein_start="60"
                     /score="114.8"
                     /tool="antismash"
                     /translation="IALSGGFPHPDTFPARALAESHARVLAQPAALQYGPTPGLPGLRD
                     WFTGWLGRAEGRTPADGELLITSGGMEGLGLITRSLLDPGDRAVVEGPTFFGALVGFQR
                     QLARVETVPVDGDGLDTDALAELLRGTTGPAPKLLYLVPDHQNPTGLTLSLERRHALIA
                     LARRYGFLVVEDVAYRELGFDGERHPSLWALAPDVVAQVGTFAKTFTPGIRLGWVVAPA
                     RLTAQLARAKQNTDQCTGAYGQLLLEDYGRSGGFDRQIAASRAFYRRRRDVMTDALAAH
                     LPEEVAYTRPHGGFFSWLTLPGDVDTVALQERALAAKVSYVPGRAFYAGEQGGNSLRLA
                     FSRVPDEQIAEGVRHL"
ORIGIN
        1 gttccggggc cgggtgctgc gggagaccgg gggcgcctcg gcgctgctgg gctttccgcc
       61 gtcggtgcac ttcacggggg cggtggacgc gctggtgggc gaggcgacgg gccgcgagct
      121 gctggccgcg ctccgcaagg cgctggccgc cgcgcaccgc aggcccgggg tctcggccat
      181 cgaggtggag gtggacgcga cggtgcggct ggccgacggg cggggcgccg tacggctgct
      241 ggtggcggac gacggccgcg acgaggagga cggccggtcg acgacggtga cctggcaggc
      301 gccgctgtga gctcccgggg cgggacgggc gcccgccgtc agtgcttcgg cgccgcccgc
      361 agggcgatcc gggtggtgga gtgggccacg cccgcctccc gtttgagccg ccgcagcagc
      421 gagtccagcg ccacggggtc ggccgccgtg gcccggatca gatagtcgtg gccgcccgtc
      481 acgtgcacca cctccgtgat cccgggcagc atcagcacgg aacgctcgaa ctcctcgttc
      541 gtcgtgtcca gccgcagcgt cacatcgatg aagacgacca ggcccgaacg ggtgtcggcg
      601 gccgggtcga tgatgacggt gaagccacgg atcaccccgt ccttgcgcat ccggcggacc
      661 cggtcgcccg ccgcgttggc gctgagcccc acgcgtacgc ccagatcccg gtacgagatc
      721 cgggcgtcct cctggagaat gccgaggatt tccctgtcca gccgatccat accgcgattg
      781 tcccagcttg tggcgatatt ggctgaggga agcgcgtgac ggccggggag ggagcgcgtg
      841 atggccgggg gaggcgcgtg acggccgggg catgacggac cgggggcggg tgccgtcgcc
      901 cggtcggcgc actccggcgg gccccgcgct cccccgcgcc cttgacttgc ggtgtgaact
      961 ccgccatcaa gcagtccccc gagccaccgg acgcccccgc cccggcggcg gccgccgcgc
     1021 cgtccgccgc cgcgtaccgg aacctcgtca tggccacgat cggcttcgcc ctcaccttct
     1081 gggcctggaa cctgatcgcg ccgatgtccg gcgactacaa ggaccggctg gggctcagct
     1141 cgttccagca gtcgttcctg gtggccgtgc cggtgctcgt cgggtcgctc ggccggatcc
     1201 cggtgggcgc gctgaccgac aagtacggcg cgaagctgat gttcccgctg gtctccgcgc
     1261 tgacgatcgt gccggtgctg ctgctgatcc cggcgaagga ctcgtacggg gcgatgatcg
     1321 cggtcggctt cctgctgggg ctcggcggca cgacgttcgc gatcggcgtc ccgctggtca
     1381 actcgtggtt cccgcccgcc aagcgggggt ccgcgctggg cgtgttcggg atgggcatgg
     1441 gcggggtggc gctgtccggc tacttcaccc cgcgtatcgc gaagcacggc gacaacctgc
     1501 cgttcctggt ggtcgcgggc gcgctggtgg tcttcgcgct gctcgcggcc gtcctggtca
     1561 gcgaccaccc cggccggaag atccccacgg acaccttggt gcaccggctg ggcgaggccg
     1621 gaaagctgcg ggtgacctgg gagctgtcgg cgctgtacgc gatcggcttc ggcgggatcg
     1681 tggcgttcgg ggtctacctg ccgacgtacc tgaagacctg gtacgagatg tcaccgaccg
     1741 aggcgggcac caaggcggcc gggttcgcgc tggtgaccgt cgtcttccgg ccgatcggcg
     1801 gctggctctc ggaccgcgtc cacccggcgc tcgtgacggc gggcgccctg ctgctggcgg
     1861 ccctgatggc ggtcgtccag gccttcgaac cgcccctgaa cccgaccggc accatcgccc
     1921 tgctggccat ggcggccggg ctcggcaccg cgagcggcag cgtcttcgcc ctggtctcgc
     1981 aggtgacccc gcaggcgaag gtgggcagcg tgacggggat cgtcggcgcg atgggcgggc
     2041 tcggcggctt cgtaccgccg ctggtgatgg gcgcgatcta cagcgccaag gactcgtacg
     2101 cgatcggctt catgctcctg tccgacctgg cgctggcggg atgcgtgtac gcgtacgcac
     2161 ggatgcggaa cctccggcgc ggcgggtgag gtctccgcac tcttcgcagc cccgccctgt
     2221 gcggccggta cggtcggcgc ccaccgggtc ggcgagctac tcgacgacga ggtcgcagat
     2281 gcctctccag tccaccgttc cgtcacctgc tccctcgtat ctctcgcggc attcctcatg
     2341 gctttcacga ggactgtcac cgttcccgcc cgggcctccc tccagaggtt cggtgaacag
     2401 cccgaggacg acgatcagaa gcagcagcga aagacagccg atcccccagg cctggcccgc
     2461 tgtcggcagt cgggtggggc cagatgtgac tgcggtgtgc acgtaccagc cttcgggccg
     2521 acgcggggtt gcgctcgcgg cttcctccgc tgcgacttcc tccgctgtgg cttcatcggc
     2581 tgtgcgcgtc tcagggcgtc tctgcgcctg cgatgcccgc tcttcggctc tccgccgttc
     2641 ccggtcggcc tcggtacgcc agcgctgcac gatgcccgac ggtgtcacac gccggacact
     2701 cgcctggtcg tgctcggcct cccgagcatg gacccgtacc gctgcagcgg ttgtcacccc
     2761 ttcggcctgc gccacgggac ctccgcacgc ctcgcatgtc cactccaccg tgccgcctca
     2821 cccacatcgc agtcgcgaaa ttcattttcg cagcagggca ggggagttga ctgcgaaacc
     2881 gtcaactcat gacgccggga gaacggccgc cgtcggccga tggtgacgct cccctcatcg
     2941 gtacccggca cccggccagg accgtcccga gcccctaggc ttcccggcgt gaccctcctt
     3001 cttcccgcgc tccagtcccc caccggcccg gcagcctccc gggaggccgt ccgcttcggt
     3061 gatctctccc tgtcctacgg ccggttggcc gaggcctccg ccgccctcgc cgcccggatc
     3121 gcggacgcgg gccgggtcgc cgtctgggcc actccgacgg cggagacggt gatcgccgtg
     3181 gtggcggccc tgcgggcagg cgtgccggtg gtgccgctca acccccgtac gggtgaacgc
     3241 gagttggcgc acatcctggc cgacagcgag cccacggccg tcctggcggg accggccgac
     3301 gagctgccgc ccgcgctgga gaaggtgccg cggatgaccg tggacgcgcg ggcggagacc
     3361 gcgggcgcga cagcgtacgg agaaggcgga gggggcgcgg cggcgtacgc ggaaggccga
     3421 ggcggcgcga cggcgcacgc ggaaggtcaa ggcggcgcgg cggcccacgc ggaaggcgga
     3481 ggcggcgcga cggcgtacgg gtacagcgga ggcggtgccc cggcgggcgg tggcgcgccc
     3541 gggcccgggg ccggcgaccc cgagtctccc gccctcatcg tctacacctc cggcaccacc
     3601 ggcccgccca agggggccgt gctcccccgg cgggccgtcg ccgcgtcgct ggacgcgctg
     3661 gaggacgcct gggggtggac cggcgacgac gtgctggtcc acgcgctgcc gctgttccac
     3721 gtccacgggc tgatcctggg tgtcctcggg ccgctgcggc ggggcggttc gctgcgtcac
     3781 ctgggggcgt tctcggccgg gggcgtggca cgggagctgg ggtcgggggg cacgatgctc
     3841 ttcggcgtac cgacgatgta ccaccggctg gcggaggtgc tggacgcccc ggcggggacg
     3901 gccgaacggg acgcgctggc cggggcgttg gccggggcgc ggctgctggt ctccggttcg
     3961 gcggcgctcc ccgtccacga ccacgagcgc atcgcggcgg cgaccgggcg gcgagtgatc
     4021 gagcggtacg ggatgacgga gaccctgatg aacacgggga tccgggcgga cggagtaccg
     4081 cgccccggca cggtgggccc gccgctcgcg ggggtggagc tgcggctggt ggaggaggac
     4141 ggcacggtgc tggaggggcc ggaggcgatc ggggagatcc aggtccgggg cccgaacctg
     4201 ttcaccggct atctcaaccg gcccgacgcc accgccgccg cgcacacggc cgacggctgg
     4261 ttccgtacgg gcgacgtcgg cacggtggac acggacgggt acgtgaccat cgtcgggcgc
     4321 aaggccaccg acctcatcaa gagcggcggc tacaagatcg gcgcgggcga gatcgagaac
     4381 gtgctcctcg gccaccccgg cgtgcgcgag gccgccgtca ccggcgaggc ggacccggac
     4441 ctcggtgagc gggtggtggc atgggtggtc gcggccgacc ccgacgcgcc gcccgccgcc
     4501 gaggagttgg cggatctggt ggcggggcag ctggccccgc acaagcgtcc gcgtaccgtg
     4561 cgctacctgg acgcgctccc ccgcaacgac ctggggaaga tcatgaagag gtcgctccat
     4621 gtccggtgac gcccccctgg ccggtggctc ccccgagtcc ggtggctacc ccgcgtccgg
     4681 tggttccccc ctggccggtg gttcccccgg gtccggtgac gatcccgccg gcgcgccgtc
     4741 cggtgcgacg ccccgggcca ccgcccgcga ggccatcgcc ctgctcaccg gcggggcggg
     4801 cttcaccgag caccggcccc cgtcgccgcg cacgctcccg ccggacggcc cgctcggctg
     4861 ggcggggtac gacatggcgc gcgcacgggc ggcggagcgg accggtgagg acgagtcggt
     4921 cgtgtacggg accggggtcg ccggtggccg ggagtgcgtg ctgctcgcct tcgagttcgg
     4981 cttcctgggc ggctcgttgg ggctgctgac gggtgaccgg ctggaggccg cgtacgacct
     5041 ggcgctcgcc cgccgtctgc cgctggtcgc gctcgtcgcc acgggtggca gccggatgca
     5101 ggagggcatg gtcgcgctca cccagctcca gcgggtggcc gccgcctcca cccggctgcg
     5161 ggcggcgggg ctcccgcaga tcgccgtggt ccgcgacccg acgaccggcg gcggctgggc
     5221 caccgtgggg gcgggcgcgg atgtggtgct ggccctgccg ggcgcccaga tcgggttcgc
     5281 cggctcccgg gtccggccgc cggacgccga cccgtacgcg tacggcgccg agggccagtc
     5341 ggcggcgggc caggtggacg cggtggtccc gggcccggag ctgccccgca cggtggggct
     5401 gtggctgcgg gcgctgggag cgggcgagga ggctgccggt accggggacg gacccgccgc
     5461 cgcgccgctc ccccgggccc aggccccgtc cgccgccggg ctgccgggga gcgggcggga
     5521 ggcggtggag cgggcccggg cggcggggcg gccgcgggcc cgggcgtatc tggacgacta
     5581 cttcgccgta cggctccccc tccacgggga ccggtccggc ggtacggacc cggggctgct
     5641 cagcgggttc gggctgcggg cggacgggcg ggccgtcgcg tacgtcgcac agtgcgggac
     5701 cccgacgcgc ccggccggat accgggcggc ggcccggacg atccggctcg cggaccgcct
     5761 cggcgtcccc gtcctcaccc tggtcgacac cccgggcgcc gccaacgacg ccgaggcgga
     5821 acgggccggc cagggcgcgg ccatcgcgga caccttcgcg gcgatcgcgg cggcccgggt
     5881 gccggtgacc accctggtga tcggcgaggg cggctcgggc ggtgccctgg ccctcgcagc
     5941 gccgggcaac acccatgtga cggcggacag ttacttctcc gtcatcgcgc ccgaactcgc
     6001 ggcggcgatc ctcaagcggc cgccggagga gacgggtgcc accgccgacc agctccggct
     6061 gcggccgcag gacctggtgg agctgggcat cgcccgctcg gtcgtccggt agggccgcca
     6121 cggccgtccg gcgggccggc ggctacggct gcgggtcgcg ggcgtcgtac cgggcgaagc
     6181 cccgccactt cagggccagc agaccgaccg ccaccacgca ggccgccccg cccccgacga
     6241 cggccacggc cggtgaggtg aggtcggcca ccgacccggc caggaagtcc ccgagccggg
     6301 gcccgcccgc caccaccacg atgaacacgc cctggagccg gccgcgcatc tcgtccggga
     6361 ccgccgcctg gagcatggtg ttccggaaga ccatggagat ggtgtcggcg cacccggcga
     6421 gcgccaggaa gagcagcccc agccagaggt ggcgggtgag gccgaagacg gcgatggcgg
     6481 cgccccagct gccgacggcg agcaggacgg cgagaccgtg gcggcggatg cggccgagcc
     6541 agccggagaa gaccccgccg agcagcgccc cgagcgccgg ggcggccacg agcatgccgg
     6601 tggtccgggc gtcacccccg taccagacga cggcgaccac cgggaagagc gcccgggggt
     6661 gggcgagcac catcgcgcac aggtcggtga agaaggtcat ccggaggttg ggccgggtgc
     6721 cgaggaagcg cagcccgtcc gtcacggagg cccgcttgcg gacctcgccc tccgccgtcc
     6781 ggtcgggcag catcgagggc agccgccaca tcgcgtacag ggaggcggtg aaggtgacgg
     6841 cgtcgacggt gtacgcggcg cggtaccccc accagccgac gatcagcccg cccagcatcg
     6901 ggccgacgag cgcgcccgtc gtcgtggtca tggagctgag cgcgttggcg gcgggcagct
     6961 gttcgggcgg cagcagccgg gcgatcatcg aggagcgggc cggggcgttg agcgcgaagc
     7021 agacggcctg gagggcgacg atggcgtaca gcaggccgac gttctcggcc ccggcgaagg
     7081 tggccagggc caggacgagg gccaggagga acgatccggc ggcgctgaac aggccgagct
     7141 tgcgccggtc gacggtgtcc gcgacggccc cgccgtagag cccgaacacg acgagcggca
     7201 cgagcgagca gaatccgatg agcccgacgg agaacgcgga gccggtgatg tcgtagacct
     7261 ggagcgagac ggcgagggcc gtcatcccct gcccgatcca ggacacggtg ttcccgaacc
     7321 agagccgccg gtagtcgggg taggcgcgca ggggggtgag gtcggcgaat atccgggggc
     7381 ggcgggcggg ctgctcggtc gtatcggtca caggggatgg taggcacggc cgctctccgg
     7441 cggtccgggc ggcccggggt gtgccggtgg cccggagggg cggcgtggtg aagtggggcg
     7501 accgccctgc cagggccttt ccgaacggag accgctgtgc cgcaccgtcc gatgcccggg
     7561 ccgatacccg gaccgccgtc cggatccgcc ttgcccgccc ggtccgcctt cctcgcccgg
     7621 tccgccgggt ccgcccggtc cgcccattcc gccgggttcg tccgccgggt ccgggtgccc
     7681 gcggccgtcg ccgtcgcctc ggtgctgctg ctcggggcgg cggcgccggg tcagcaaccg
     7741 cgtacgggcg gggcggtggc cggaacggaa ccggtggggc ggatgccgct cggccccgcc
     7801 gacgtaccga cacagaccag acccgccgac ctgctggctc ccggggtcac ctaccgcaag
     7861 tactggcagg gcgaggcctc ggacgcctgg tcggtctggg tccgccatcc gcaggcgggc
     7921 acggagacct tcggatcgtg ggcggacgcc gaccggctgg cgagggacct ggacgcggcc
     7981 ggattcaccg cccgcgtcga tgtcttcacc gtgccggaga gcgtcgacac ggacagccgg
     8041 gtggtggggt acggggtccg ggtcggccgg ttcgccgccg accgccggga ggacgccgtc
     8101 caggcccggc aggcgctggc ggacgccggt ttcggcagga gccggatctt cttcaccgcc
     8161 gaggacggga gcgcgagccg gggcccgtgg caggtcaggg tgatcacggt cgcgccgtcg
     8221 gcccgggtca cgctgaaggc cgtgcacggc aaggacgtcc agggctccga gaccgtacgg
     8281 caactggcgg cggagagcgg ggcgctcgtc gcggtcaacg gctcggagtt cgacatcgac
     8341 agccccaaca acggtgactt cggcggcttc gaaggcgtac cgcagggcct gtacctccag
     8401 aacaacgtgc tgctcggcac cccgaacaac ggcaggaccg cccttctgct ggaggggctc
     8461 cagggccggg ccgccgtgga cgagatcagc tccgagaccc ggatcaccgc acccgacggg
     8521 gcggtacggg tggtcgacgg catccaccgg ccggccggtc atgtgctggg ctgcggcggg
     8581 gtcggcaacg actaccgcgc ttccgaccgc acccggacgc tccagccccg gcggaacacc
     8641 acctgccacg accccgacga gatcgtggtc ttccgcccgg agtggggcgc caccaccccc
     8701 accccggtgc gccggggcga cagctggacc gaccccgtca ccgggtggca ggcgcagtgg
     8761 tacgcggacc gggcggagtt cctggcgcac acggtcgacg tggtcatgga cggcaactgg
     8821 gtcgtcaagc agctccgtac cccggcgggc ggcccgatcc cgcccggcgg ccgggtcctc
     8881 cagggcatcg gggagggcgc cgcctggctc cgcgcgcaca gcgaggtcgg caaggcgttc
     8941 aagcccggct ccacggtccg gggccgggac ggcaggtccg tgaccacccc ggcgctctcg
     9001 gcggtggcag gcggtacgcc ggcgctggtg cggggcggcg aggtgtggct gaacccggcc
     9061 gccaacggga tggcccaggc ctcctgcgta ccggccgacc tcgccccggg gcagaagtgc
     9121 cgtgccaaca acacgctgtt gcagcgccac gcccgtacgc tcgcgggggt caccgccgcc
     9181 ggtgagctgc tgctcgtcac catcgacggc cgcgacccgg cgctgagcgt gggagcgacg
     9241 ctgcccgagg cggccgcggt gatgaagtgg ctgggcgccc gggaggcggt ggggctcggc
     9301 agcggcggcg acaccaccct catcgccggg aacacgctct acaaccggcc ggtggacgac
     9361 tggggcgggc ccctgcgcga gcggcgcgtg agcaacgccg tggtcgtcgt cgagaagccc
     9421 tgagccggga ggctgagcgg gggggctagg ccggggctga ggggcctgag cggggaggcc
     9481 gaagccgggg agcccgagcc gaggggccgg ggccgaggag cctgagccgg gaggccgaag
     9541 ccggggaacc cgagccaagg ggccggggcc gaggagcctg agccgggagg ccgaagccgg
     9601 ggaacccgag ccgaggggcc ggggccgagg agccggggcc gaggggcccg agccaggaag
     9661 ccggagccga ggggcccgag ccgggaggcc ggggcccgag tggcgcgggg acgatgcctt
     9721 cggccgaggc ccgggacccg ggccgcgagg gggctgccgg gaaggcaatg tgtctcatgt
     9781 ggtcggagtg gctgtgtctc atctcgccgc gcccgtccgg cgcccccggc cgtcccctcc
     9841 cccgcgcgcc ccgcgcgcca cctgcggcgg agccgaaccg tacgggccgg tcggccggtt
     9901 ggctgtctca ggtggacctt gacggtccgg tcggccgccg gttgcattcc tatcccgggc
     9961 atcaggattc accgggtgga gcacacacga tgggggagcc atgggggaga ccgagatcga
    10021 gctgacaccg gccagtgttc tgcagcgccg ggtggaggcc cgcgcgcgcc ggtaccgggg
    10081 gcggatgtat gtggccgtgc gggagcacgc gttggagctg gacgaggtgg cgcaggccat
    10141 cgtccggcgg atcgacggta cgtcgacgct gcgcgggatc gcggccgtgg tggcggagga
    10201 gtacggcgtc ccggccgaga acgccaccgg cgacacggtc gagttcgccg cccaactcct
    10261 cgcgcacggg gtggtggagg tcgtccccgg gtgaccccga agcagccccg ggcggccccg
    10321 ggcgacgctc ccgggaggcg gccgcccccg ggtcggggcc ggtggcgcca ccaccccggc
    10381 aacccggttc cgtacgggta gggcaccatg gccatgccgt acaagaacgt gaacattgac
    10441 gccgtcgaag agaacagtgt tcactcatac cgaacagggg tgggcccatg gtcgagtcgg
    10501 tcaagcgcgc cgtacgcatc atcaaggagc tgacggggtc ctccccccgg ctgggggtca
    10561 ccgaactcgc cgaccgggtc ggggtgtcga aatcggccat gcacggcctg ctccgcaccc
    10621 tggagtcgga cggcctggtg gtgcaggacc aggagtcggg caaataccgg ctgggaccgg
    10681 ccctggtgac cttcggcaac gcctacctgg acacgcacga gctgcgcacc cgcgccctca
    10741 cctggtccaa tctgctggcc acccggaccg acgaggcggt ctgggtcggg gtgctggtcc
    10801 atgacgacgt cctcgtgatc caccacgtct gccggccggg aaacgtggcg cagccgctgg
    10861 agaccggggc cacgctgccc tggaacacca ccgcgctggg caaggccatc gtggccttct
    10921 cccccgagga gctgcgaacc cgtctgctca gccgcccgcc cgctgcgctg accggccact
    10981 cggtgaccga acccgaactg ctggaagcac agttggcgca ggccagagag gtcggctacg
    11041 ccgtggagaa gcaggaggcg acgctcggcg acgcgggcat cgcggccccc atcttcgacc
    11101 gcaccgggtg cgcggcgggg gccatcggcc tcgtcggccc ggtcgaacgc ctgctggacg
    11161 aacggcaccg gcagggctgt tcgatcgcga cccgcgagac ggcccgcagc ctctcgcgcg
    11221 aactcggcgc ccaccggttc ggcaaccggg tcgcctcctt ctgaaccgct cccccgcccg
    11281 gtccgtcggc cggtccgccg aagccgccgc caccgcccat caccacgccc ccgtcacgct
    11341 cgacccgccc cgtccgcacc gcccccgacc cgctgccacc gccccgatcc gccccctcgc
    11401 gccctgtcgc ggacccggcc ggaaccggtt ccaccgggac cccggccggg cggccccgac
    11461 cgacactacc cacgccccac gccgaccaat cccggccgat tccaggagcc cgcgcgcatc
    11521 cgatccgtcc gcttccgctg aggtatgtgc cggtgcgtac accggcaaca gccgttgctt
    11581 gacacgccat ttggaccgcg cctagctttc gagcaagcgt tctgcaccga agaacatcgt
    11641 tcgattcaac gctccggcag gcaggtcggc cgctcacccc gagcgaccgc gggtggaggg
    11701 ggccaccgtc aggaagccga tcgaccgcgc cggaacgcag cacgccgttc ccgaagcaac
    11761 ctcacccggc ggcatgcccg tcttcacgac agggtcgtcc gacggacggg gccggagagc
    11821 agccgatgac cacggcagag ggaggacagg tggactccgc accgacgcag acatggctgc
    11881 gtgcagcggc agtacgcatc gaccgacagc aggaaccacc cactcgacag gacctggccc
    11941 acagcgacgg tggccacggt gacgacacgc ggtgcggcct cccggccgcg cgcgtcctcc
    12001 gcccgctcac gaccgccctg gagaggacat gacccaccaa ggcaatccgt tacccccgct
    12061 gcggcggacg aacagcaccc tcccggaggc gagggtgccc ggcccccgcg tccccctccc
    12121 cggcgcgggc cggttcacct ggctcgcccc gatggccctg tggccgctgg cccgccggca
    12181 cctgccccgc ccggcggtcc gtccgcaggg cggcggcagc caacgggccg acgacgaggc
    12241 gaccttcgcc gccatcctgt tcgtcctggt cagcggcgta ccctggcggg ccctgccccg
    12301 ggcgttcacg gtgtcctggc agaacaccca ccgccggttc acccagtgga gcgcggcggg
    12361 gctgtgggac cagctccggg agagcgccca ccggcagcac gccccggggc agtcacgcga
    12421 gctggtgcag tgggcggagg ccgtctgcga gctggccgag gagcggctga accggacggc
    12481 tcccccgtcg gcgggcccgg cggccgcgcg gcggcgggcc gggagcctgc agccccgtct
    12541 gcgggtgcgc gagcccgacg acttcaccgt ccgcctcttc ggccccggcc gggactcggc
    12601 gtggtgaccc cggccggaag cgccggactg accggctgcc tggaggagat ggaccgccgc
    12661 gggctgatac cggacggctg cctcgcggtc tgctgcgtcg gacccgccgc tcgcggctgg
    12721 gccgacgagg gcggcacgta cgacttccac gtggtctcca ccggtccgtg gaccggcgag
    12781 ggcgcccgcg cgctgcccgt gcggctctcc ccggccgaag tcccttcgct ggcgctgtcg
    12841 gtggcgggcc ggcgctggga gatcacgtac tggctggagg gccaggtccg gcaggtgctc
    12901 gccaaggtca cccgggaacg gttcgagggc ggcggcacgg cggtcggggt gctgaccgac
    12961 gccgaggagc tgttcctgga acggatgagc gcccctctcg cgctcagcgg tacggagtgg
    13021 gcgaaggagt gcgagcggcg gatcggcggc tccgcgttcc gggccttcgt gaccacccgt
    13081 tcgctcgccg ctgccgaccg ggccatcgag gacgcggggc gccggctggc cgcccgggac
    13141 gttcccagcg cggtgctctc ggcccgttcg gcgctggggc acacggtgga cgcgctgctg
    13201 gagagcgaga gcgacttcgg ctcccgggcg ccgcgccggc gggcccggcg gctgcgggag
    13261 acccggccga gggcgctgcc gttcgcggag tactgggcga tggagaccat gcgctcctac
    13321 gatccggcgc ggccggagga gtgggtgacg acggtggtgc agcggtgccg ggacctggcg
    13381 ttcgaggtgg agatctcctg agggggccgg gggtggtccg gggctcccgg accaccccct
    13441 ccgtcagccc gtcgagtccg ccgactgggg agcccggtcg gcctgtccgt ccttcggcgt
    13501 cccgtccgcc gcctgctcct ccggtccgtc gtcggcgccc ggatgctcgt cgtccgggca
    13561 ccaggtggcc cgggagaagc gggcggcgac catcagcacg ctcgccgcgg ccagcgccgt
    13621 cccggcggcc agccaggggg tgcccggcga gcggccggcc gagagcaccc cgccgatctg
    13681 cggcgccgtc atgaatccga cgttgacgcc cgccgagtac aggctcacat tgcggttgat
    13741 caccgtcggc gcggagagct gggagacata gctgagcagg gccgggaaga cgatcatctc
    13801 cccgcaggtc cagagcagcg cgatcaccgc cagcagcggc ccgctggagg tgagcccggt
    13861 gagggcgaac ccggccgccg ccagcacgta gccgatgagc agtgaccgca ggtgggacat
    13921 gtggaccatg gccttgttca gcggcacctc gaacagcacg atcgccgccg cgttgaccac
    13981 gaagacgaca ctgacccagt aggcgggcag cccgatgccc tcgatgatgt acgtgctcag
    14041 caggatcggc ggcagcgcgt acgcgatgtg caccggcagg gccaggacga acagggtcca
    14101 gaaccgggac tcgtcgcggg cggtgggcga gagcagcctg cccggtccgg gcgcctcggc
    14161 ggtcgtggcc gaccgggtgg aggcggagcg gcgcagcagc actccggcgg cggcgaggac
    14221 gcagacggcg ttgacgtaga acagcgcctg cggagccacg gtgaagagca gaccgccgac
    14281 cgccggaccg aggcccatgc cgaggttgat cgccagccgg ttgcaggaga aggcgatctt
    14341 ccgctgctcg gccgaggagc ccgccacgac ctgcgcgtaa ctggcgggcg tgtagatctc
    14401 gaaggccatg ccccacagca gggtggcgac gaggagcgcg ggcacggcgg agagcgcggg
    14461 cacgacggcc agcaccaggg cgtagccgac gcagccgccg agcatcaccg tgaccggccg
    14521 cagccgtccc agcagcaccc ccgcgcccac gtcggcgacg agcgccccga ggccgaaggc
    14581 accgacgacc aggccgacct gctcgacgcc gtaacgttcc tgtccgagca gatacgcgcc
    14641 gaggaagggg aaggccatcg tccccgcccg gaagagcagg gtggagacga acagggcccg
    14701 cagatcgctg ttgagtccgg cgaccgtgcg gaacgtgccg cggatcatga cgggtcgtgc
    14761 tccgcctcga cggtgaagat ctgctccgta cgctgccggg ccagctcgtc ggccttggcg
    14821 cggaaggccc gctggtcgct ctggccccgc tcgaagcact ccaggacgcc gtcgcgcgcg
    14881 aggtacgagg tcagcggccg ggagacgtcg cccacctggg cggtgatgta gaggccgacc
    14941 tcctcggggg tcaggtcgtg gaccggcttg acctcggtga tcgtgccggg cggcgccttg
    15001 aggaaggccg tggcccccat gccggcgggc tccgcggtga tggcgggcag gccgtccagg
    15061 gtgtccgtgt acgaaccgaa gtggaggtcg taggggctga agccgtagac gcggtcgatc
    15121 aggtccatga tcccgtcgcc gccgggccgg gccgccacct cgacgacgct cagccggtcg
    15181 ccgtcgacca ggacctcgac atgggccagt ccgtggtcga tgtcgagcgc ggcgcaggcg
    15241 gccagggcga cccggcgcag ctcctcgttg ccggagtcgg cgctcggcac cagctggccg
    15301 cgctcgctga agtagggggc gcccgccttg gacttgtcgg tgacggcgac gacggtgcgc
    15361 tcaccgcggt ggttggcgac ctcgacggag acctcgtggg tggaggtgac gaactcctcg
    15421 gcctggaagc ggccgtcctc gaacccgtac agcggggcga tctccagcag ggagtcgcgg
    15481 cagtagacgt acgcctcgtc cagctcgccg gggccgttga cccgcacggt gccgacgttg
    15541 ccggcgaagt cgcgcggctt gagcaccagc gggaagtcca gctcccgggc cgcctggtgg
    15601 agttcctcca gggtgccgaa gaggcggtgg cgggcgcagg gcactccggc cgcctcgaag
    15661 gccgccttca tcgtgtgctt gtcgcggacc ttggccaggc aggcgtcgga gagccggggc
    15721 aggtcgtagt ggcgggcgac ggcgacggag acgtgcacgg tcatctcgat gatcggcacg
    15781 accgcgccgg gccgcagccc ggtctcgcgc tcgaactgct ggacggcttc gagggcctgg
    15841 cgctcgtcgt agtagtcggc gcgcaggacg tggtcgaaga agcggttggc gttctgcgcg
    15901 gccggggtct cgctcatccc gatcaccggg ccggggtagg tccgcagcgc cgagacgacg
    15961 ccgcgttcac ggagcaggat gtcggagccg agcagcagca gatagcggtc gccgttggca
    16021 tgggcgcgcg cgagatcgaa cacggtggtt cccccatttt tcgaaagagg acttcgacag
    16081 aagacggcgt gccacggagg ggcgaaggcc gcgtttcggg aaaggccgcg cgggtcgtgc
    16141 gcgggtggct gtggcggccg gtcgggtcac ggcccgccac gggggcgccg ccgccgggtg
    16201 gaaccggcgg cggacgcccc tcactcggtc gtccggaggt cggtccgggg accggtccgg
    16261 tggaccggtc cgaaggtgcc gggccggccc tcggaacgaa ggtgccgggc cggccctcgg
    16321 aacgaaggtg ccggaccggt cctcggagcg aaggtgtcgg accggccctc ggaccggagg
    16381 ccggcccgag ggtgtcgtca gcggatcggc ccgaaggcgg gtccgaacgg tcagtagcgg
    16441 tagtggtccg gcttgaaggg accttcgatg tccacgccga tgtactcggc ctggaccttg
    16501 gtgagttcgg tgaggtgggc gtcgagggcg gggaggtgca ggcgcgccac cttctcgtcc
    16561 aggtgcttgg gcagggtgta gacgtcggtg ccgtagttct gcgccgggtc gaagagcgag
    16621 atctgcgcca gggtctggtt ggcgaacgag caggacatca cgaagctcgg gtggccggtc
    16681 gcgttgccca ggttgagcag gcggccctcg ctgagcacga tgatcgagtg cccgtcgggg
    16741 aaggcccact cgtggacctg cggcttgatc tcggtcttct cgatgcccgg cacctgcgcg
    16801 agaccggcca tgtcgatctc gttgtcgaag tggcccacgt tgccgacgac ggcgttgtgc
    16861 ttcatccggg ccatgtggtc ggccatgatg atgtcgcggt tgccggtggt ggtgatgaag
    16921 atgtcaccgg tctcgacgac ctggtcgagc gtgacgacct tcagaccgtc catggccgcc
    16981 tggagcgcgc agatcgggtc ggcctcggtg accacgacac gcgcgccctg gccgcgcagg
    17041 gacgccacgg cgcccttgcc gacgtcgccg tagccgcaga tcacggcgag cttcccggcg
    17101 atcatgacgt cgatggcgcg gttgatgccg tccaccagcg agtgacggat gccgtagcgg
    17161 ttgtcgaact tgctcttggt caccgcgtcg ttgacgttga tcccggtgaa gaggagcttg
    17221 ccctccttgc cgaggcggta gagccggttg acgccgttgg tggtctcctc ggtgacgccg
    17281 acgatgaact tcgccatctc cgagtacttg cccgggttgt ccacgagcga gcggcggagc
    17341 acgtcgagga tgatccggtg ctcctccggg tcgtcggcga gcgcgtccgg gacggcgccc
    17401 gccgtctcgt actcggcacc caggtggacc agcagggtgg cgtcaccgcc gtcgtcgacg
    17461 atcgagtgcg ggccggagcc gtcgggccag gtcagcagct gctccaggca ccaccagtac
    17521 tcctccagcg tctcgccctt ccaggcgaag acggcgctgc ccttgggctc ctccaccgtg
    17581 ccctcggtgc ccacgacgac ggctgcggcg gcctggtcct gggtggagaa gatgttgcag
    17641 ctggcccagc ggacgtcggc gccgagcgcg gcgagcgtct cgatcaggac ggcggtctgg
    17701 atggtcatgt ggagagagcc ggcgatacgc tttccggcca gcggctgctg cgggccgaac
    17761 tcctgccgca gggccatcag tccgggcatc tcgtgctcgg cgagacggat ctccttgcgg
    17821 cccagctcgg cgagtgagag atcggcgacc ttgaatcccc cgaccgaccc ggcactgtcc
    17881 gcggtcaacg caacagccat gctgtcattc tccctgtctg gaaatgctgg tgacgaaacg
    17941 tcagcggctt ttgggtccaa ctctctcatg tggcctcgga acgagcatgc cattcccgct
    18001 cgtggacgcg atagctcggc cgattacaga tggccgaatc gcgccagcag ttccggaagc
    18061 gtcgcccccg cgttcatcag atcgcgcacg atccgctctt ttgccagcaa ctcccttgtc
    18121 gaagcggcta cttcctccgc cgcgtcgggc ggcacgacgg ccaccccgtt ctcgtcggcg
    18181 accacgatgt cccccgcccg cacggtcacc ccgtcgatcg tcaccggcac gttgacctgc
    18241 acgacaccgt ccaggtcggc cggcgggcag cggcgcggct gggcggtgcg gtaccagacg
    18301 gggaggccga ggtcgcgtat ctcgtccacg tcccggacgg ccccgtcgac gacggcgccg
    18361 gcgatccccg ccacctgaga caaagtcgtc atcaggccac cccacatcgc catcccggtg
    18421 atcccgtgac aggccagcac gatgacgtcc ccgggccggg cctgtccgag caccgggagg
    18481 atgtcgacca ggtcctgctc ggagaggtcg atggtcaggg cggggccgac gacccggtgg
    18541 gcggggttga cggtgagcag cccgccgatg gcgccgatac ggtccccggc gtcggcggcc
    18601 aggcagctcg ggctgtactc ggggagcagc agctcgcgca gggcgtcgac gccgggcggg
    18661 gcggacggcg gctcggtgga ccgggtgggc tgggtgggca tggcggggcc cttctccttc
    18721 atgagggtgg aaaggaatgg gacagcggtc agtgctcagt ggtcagtggc cggcgcgcgg
    18781 tgtcggggcc gcgggggcgg tggtcagcgc gtggtggtgg cgccgatcgc ctcggcgagg
    18841 acgccggaca gatggcgtac gccctcggcg atctgctcgt ccggcacccg gctgaacgcc
    18901 aggcggaggc tgttgccgcc ctgctccccg gcgtagaagg cgcgccccgg cacataactg
    18961 accttggcgg ccagcgcccg ctcctggagc gcaacggtgt cgacgtcccc gggcagggtg
    19021 agccagctga agaagccgcc gtgcgggcgg gtgtacgcga cctcctcggg cagatgggcg
    19081 gcgagggcgt cggtcatcac gtcccggcgg cgccggtaga aggcccggga ggcggcgatc
    19141 tggcggtcga acccgccgga cctcccgtag tcctccagca gcagctgccc gtaggcgccg
    19201 gtgcactggt cggtgttctg cttggcgcgg gccagttggg cggtgaggcg ggccggggcg
    19261 acgacccagc cgagccggat gcccggggtg aaggtcttgg cgaaggtgcc gacctgggca
    19321 acgacgtcgg gggccagtgc ccagaggctg gggtggcgtt ccccgtcgaa gcccagctcg
    19381 cggtaggcga cgtcctcgac gacgaggaac ccgtaccgcc gggccagcgc gatcagggcg
    19441 tggcggcgct ccagggagag ggtgaggccg gtggggttct ggtggtccgg gacgaggtag
    19501 aggagcttgg gcgccggccc ggtggtcccg cgcagcagct cggccagggc gtcggtgtcc
    19561 agcccgtcgc cgtcgaccgg cacggtctcc acccgggcca gctgccgctg gaagccgacg
    19621 agggcgccga agaaggtggg gccctcgacc acggcccggt cgcccgggtc gaggaggctg
    19681 cgggtgatga ggccgaggcc ctccatcccg ccgctggtga tgagcagttc gccgtcggcg
    19741 ggcgtccgtc cctcggcccg ccccagccaa ccggtgaacc agtcgcgcag cccgggcagc
    19801 ccgggggtgg gcccgtactg gagcgcggcg ggctgcgcga gcacccgggc atggctctcg
    19861 gccagcgccc gggcgggaaa ggtgtcgggg tgcgggaagc cgcccgagag ggcgatggcg
    19921 tcggtggcgc cggactggtc gaggatggcg gtgatctggt cgccggtgtc gctcgccaca
    19981 tgacgggcga acagccggtc ccagctcggg acgccggggc cggggacgcc agggctctgg
    20041 gcggcggggc cgaggtcggc gaggtcgagg gcggcggggc cggggtcagc gggcatgtgc
    20101 gggcctctct tcacggtcgg tgccgaggtt cgggtcgcgg cgggggccgg cggcttggtg
    20161 gggtacggga gcgggtgccg gcgcctggtg cggtgcgtgc tcccgtacgg cggtgggccc
    20221 ggggtcctgg gccggtgtgc gatccggtac ggggaccggg gcttggtgcg gtacgggggc
    20281 gggggtctgg ggtg
//
