GCF_000340475.1 - 8 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CM001792.1 (Oceanobacillus kimchii X50)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	terpene	408,625	429,446
Region 2	ectoine	469,394	479,780	Medium	ectoine	other:other
Region 3	RiPP-like	608,071	620,227
Region 4	NRP-metallophore,NRPS	960,247	1,011,888	Medium	bacillibactin/bacillibactin E/bacillibactin F	NRPS:Type I
Region 5	T3PKS	1,746,721	1,787,812
Region 6	terpene-precursor	1,878,164	1,899,048
Region 7	T3PKS	2,255,976	2,297,142
Region 8	lanthipeptide-class-ii,terpene	3,531,091	3,561,424

NZ_CM001792.1 - Region 1 - terpene

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Location: 408,625 - 429,446 nt. (total: 20,822 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: phosphorylase

C794_RS02395: thiamine-phosphate pyrophosphorylase

smcogs: SMCOG1280: thiamine-phosphate pyrophosphorylase

Ligases: synthase

C794_RS02360: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000883.5	0.39	other (other)	arginomycin	Streptomyces arginensis
BGC0001863.4	0.38	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000635.3	0.38	terpene	carotenoid	Paracoccus sp. N81106
BGC0000630.3	0.38	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0002488.3	0.33	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002346.3	0.32	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000579.4	0.31	ribosomal	SSV-2083	Streptomyces sviceus ATCC 29083
BGC0000814.3	0.31	other (other)	K-252a	Nonomuraea longicatena

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000883.5	0.39	other (other)	arginomycin	Streptomyces arginensis
BGC0001863.4	0.38	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000635.3	0.38	terpene	carotenoid	Paracoccus sp. N81106
BGC0000630.3	0.38	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0002488.3	0.33	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002346.3	0.32	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000579.4	0.31	ribosomal	SSV-2083	Streptomyces sviceus ATCC 29083
BGC0000814.3	0.31	other (other)	K-252a	Nonomuraea longicatena

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

C794_RS02380: PT_phytoene_like

Domain 1 (14 - 258): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.37 out of 26.85

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.13 out of 26.06

Confidence: strong

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.71 out of 30.25

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.57 out of 27.18

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
RutR	Regulator of the pyrimidine and purine metabolism

NZ_CM001792.1 - Region 2 - ectoine

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Location: 469,394 - 479,780 nt. (total: 10,387 nt) Show pHMM detection rules used

ectoine: ectoine_synt

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

C794_RS02655: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: synthase

C794_RS02680: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0002052.3	0.68	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.68	other (other)	ectoine	Streptomyces anulatus
BGC0000858.3	0.67	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000857.3	0.64	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.58	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000860.3	0.54	other (other)	ectoine	Methylarcula marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0002052.3	0.68	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.68	other (other)	ectoine	Streptomyces anulatus
BGC0000858.3	0.67	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000857.3	0.64	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.58	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000860.3	0.54	other (other)	ectoine	Methylarcula marina

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.53 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_CM001792.1 - Region 3 - RiPP-like

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Location: 608,071 - 620,227 nt. (total: 12,157 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene overview

Tailoring

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KnownClusterBlast

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000588.5	0.44	ribosomal	microcin L	Escherichia coli
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.43	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000584.5	0.41	ribosomal	colicin V	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001555.4	0.47	ribosomal	colicin V	Escherichia coli chi7122
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000588.5	0.44	ribosomal	microcin L	Escherichia coli
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.43	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000584.5	0.41	ribosomal	colicin V	Escherichia coli

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.55 out of 36.53

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.24 out of 20.47

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.24 out of 20.47

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.61 out of 32.74

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_CM001792.1 - Region 4 - NRP-metallophore,NRPS

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Location: 960,247 - 1,011,888 nt. (total: 51,642 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

C794_RS05215: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C794_RS05310: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase

C794_RS05345: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

C794_RS05305: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

C794_RS05325: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

C794_RS05315: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

C794_RS05320: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

C794_RS19720: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Translocases: transport

C794_RS19710: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.98	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000343.5	0.84	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002075.3	0.84	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000309.5	0.83	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.81	NRPS	paenibactin	Paenibacillus elgii B69
BGC0001132.4	0.75	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.73	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.78	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000343.5	0.73	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000309.5	0.73	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.72	NRPS	paenibactin	Paenibacillus elgii B69
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.15 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.77 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.79 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.95 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 29.45 out of 32.74

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (5):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.79 out of 30.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.67 out of 32.74

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.78 out of 18.46

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.98 out of 30.22

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.41 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 960246 - 1011888:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C794_RS05320: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (30..436): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SKSLFTMSSPGGSLQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz TMPSQGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

C794_RS19720: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (461..860): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FYMTFDISILELQALVGGETNLYGPTETTIWSTV
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1509..1919): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LETHFDFSVWEGNQVFGGEINMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CM001792.1 - Region 5 - T3PKS

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Location: 1,746,721 - 1,787,812 nt. (total: 41,092 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

C794_RS09200: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C794_RS09215: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

Transferases: aminotransferase glycosyltransferase methyltransferase

C794_RS09305: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

C794_RS09375: aminotransferase

smcogs: SMCOG1019: aminotransferase

C794_RS09405: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Isomerases: mutase

C794_RS09230: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase

C794_RS09310: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001454.5	0.75	other (other)	germicidin	Streptomyces argillaceus
BGC0000282.3	0.67	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001831.3	0.46	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001184.4	0.41	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000905.5	0.41	other (other)	heme D1	Heliobacillus mobilis
BGC0000888.5	0.41	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.40	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000671.3	0.39	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001267.3	0.38	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001454.5	0.75	other (other)	germicidin	Streptomyces argillaceus
BGC0000282.3	0.67	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001831.3	0.46	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001184.4	0.41	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000905.5	0.41	other (other)	heme D1	Heliobacillus mobilis
BGC0000888.5	0.41	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.40	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000671.3	0.39	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001267.3	0.38	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 21.42 out of 23.79

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.31 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.59 out of 24.78

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 25.88 out of 25.88

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.85 out of 24.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78

Confidence: medium

Additional weak hits (3):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.85 out of 29.65

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
PsrA	Oleic acid responsive regulator

NZ_CM001792.1 - Region 6 - terpene-precursor

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Location: 1,878,164 - 1,899,048 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase phosphotransferase

C794_RS09980: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

C794_RS09995: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthetase

C794_RS09955: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000043.5	0.35	PKS	curacin A	Moorea producens 19L
BGC0000528.5	0.35	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001605.3	0.35	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000234.5	0.35	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000665.5	0.35	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000678.5	0.34	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000043.5	0.35	PKS	curacin A	Moorea producens 19L
BGC0000528.5	0.35	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001605.3	0.35	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000234.5	0.35	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000665.5	0.35	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000678.5	0.34	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

C794_RS09955: PT_FPPS_like

Domain 1 (33 - 294): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.65 out of 27.78

Confidence: medium

Additional weak hits (1):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CM001792.1 - Region 7 - T3PKS

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Location: 2,255,976 - 2,297,142 nt. (total: 41,167 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

C794_RS19830: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Ligases: synthase

C794_RS11890: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.44	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3	0.43	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002567.2	0.41	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0000487.5	0.39	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000497.3	0.38	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002561.3	0.38	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000552.3	0.37	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001870.3	0.37	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002487.3	0.44	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0002488.3	0.43	other (other)	bacillopaline	Paenibacillus mucilaginosus KNP414
BGC0002567.2	0.41	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0000487.5	0.39	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000497.3	0.38	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002561.3	0.38	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000552.3	0.37	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001870.3	0.37	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.33 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.92 out of 24.78

Confidence: medium

Additional weak hits (2):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.15 out of 36.54

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.73 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
ZuR variant 1	Zinc-responsive repressor

NZ_CM001792.1 - Region 8 - lanthipeptide-class-ii,terpene

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Location: 3,531,091 - 3,561,424 nt. (total: 30,334 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

C794_RS17935: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

C794_RS18045: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Lyases: cyclase

C794_RS18000: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

C794_RS20010: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

C794_RS20015: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.71	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001229.4	0.38	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000504.5	0.37	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000516.4	0.36	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000517.4	0.36	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.36	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000554.4	0.35	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001391.3	0.33	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000527.5	0.33	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000499.3	0.32	ribosomal	butyrivibriocin OR79	Butyrivibrio fibrisolvens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.68	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000516.4	0.56	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.54	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002110.3	0.53	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000527.5	0.52	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for C794_RS20010

C794_RS17975

Leader:

MDIIKNSSKRIEINTSFENHPAGEISEEELLAISGG

Core:

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

Core with dehydrations:

QVEQNDhaLDhaPLDhbPDhaDhaGDhaCysVAIDhaLAFCysPDhbDhaACysDhbDhaDCysDhbEW

antiSMASH-DB 4.0 matches for C794_RS17975

100.0%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

1

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

37

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

1

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

37

41.0%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

8

SPLTPSSGSCVA----ISLAFCPTSACTSDC

34

+PLT SS CV IS CPT+ CTS C

9

TPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

40.5%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

11

TPSSGSC-VAISLAFCPTSACTSDC

34

TPSS +C +A+S FCPT+ CTS C

8

TPSSVACGIAVSALFCPTTKCTSQC

32

with 97 more sequence matches

Only the first 10 are displayed here.

40.5%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

17

CVAISLAFCPTSACTSDC

34

CV +SLAFCPT+ACTSDC

18

CVPVSLAFCPTTACTSDC

35

40.5%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

9

PLTPSSGSCVAISLAFCPTSACTSDC

34

P+T SS C S AFCP++ACTS C

3

PITTSSWICGVASAAFCPSTACTSKC

28

38.5%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

8

SPLTPSSGSCVAISLAF-----CPTSACTSDC

34

+P TP+ G V AF CPTSACT C

8

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

39

37.8%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

11

TPSSGSC-VAISLAFCPTSACTSDC

34

TPSS C V ++ AFCP++ CTS C

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

37.8%

NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

8

SPLTPSSGSCVAISLAFCPTSACTSDC

34

+P TP+ VAIS+ CPT+ CTS C

8

TPATPTI--VVAISVGLCPTNRCTSKC

32

36.8%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

8

SPLTPSSGSC----VAISLAFCPTSACTSDC

34

+P T SS +C V +S + CPT+ CTS C

8

TPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

35.9%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

10

LTPSSGSC----VAISLAFCPTSACTSDC

34

LT SS +C V +S + CPT+ CTS C

11

LTTSSWTCITAGVTVSASLCPTTKCTSQC

39

35.1%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

11

TPSSGSCVAISLAFCPTSACTSDC

34

TP++ + VA+SL CPT+ CTS C

8

TPATPTIVAVSLGICPTTKCTSKC

31

35.1%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

11

TPSSGSC-VAISLAFCPTSACTSDC

34

TPSS C ++ +CP++ACTSDC

8

TPSSLPCGTLVTAVWCPSNACTSDC

32

35.1%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

8

SPLTPSSGSCVAISLAF----CPTSACTSDC

34

+P TP++ VA+S CPT+ACT C

2

TPATPATPVIVAVSAYVSDKTCPTTACTRAC

32

MIBiG 4.0 matches for C794_RS17975

35.1%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

LSPLTPSSGSCVAISLAFCPTSACTSDC

34

L + +G V +S AFCPT+ CTS C

10

LGIVAIQAGVAVGVSAAFCPTTKCTSRC

37

21.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

24

FCPTSACTSDC

34

FCPT+ CTS C

16

FCPTTKCTSKC

26

C794_RS17980

Leader:

MKEKVKAWKDPLARDVHTSHPSGDIFSEISDEEMYKLSGG

Core:

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

Core with dehydrations:

DhaAEDhbQDIDhbLPIDLCysWLDhaRLGGNQGWFCysDhbIDhbKECysQVNCysNVG

antiSMASH-DB 4.0 matches for C794_RS17980

100.0%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17980_lanthipeptide

Lanthipeptides: C794_RS17980_lanthipeptide

1

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

40

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

1

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

40

41.5%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptide

Lanthipeptides: BUE45_RS13060_lanthipeptide

1

SAETQDITLPIDLC-WLSRLGGNQGWFCTITKECQV

35

+ T IT P+ C LSR N G FCT+T EC V

3

APNTISITNPLIACALLSR--NNTGRFCTVTVECNV

36

40.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GNQG +CT+TKECQ NCN

8

LSDFLGNQGGWCTLTKECQPNCN

30

with 117 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

15

WLSRLGGNQGWFCTITKECQVNCN

38

WLSR GN G+ CT+TKECQ CN

4

WLSRKLGNTGYVCTLTKECQRMCN

27

40.0%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide

Lanthipeptides: HBA49_RS00770_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LSRL GN G +CTITKEC +CN

1

LSRLLGNNGRWCTITKECMPSCN

23

40.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GNQG +CT+TKECQ NCN

8

LSDWLGNQGGWCTLTKECQPNCN

30

37.5%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

7

ITLPIDLCWLSRLG-GNQGWFCTITKECQVNCN

38

+ I C L +G GN GW CT T ECQ C

5

VAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

37.5%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSDALGNHGGWCTLTKECQANCN

30

37.5%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSDALGNSGGWCTLTKECQPNCN

30

37.5%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSDAVGNHGGWCTLTKECQPNCN

30

37.5%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN GW+CT+TKECQ CN

8

LSDAAGNDGWWCTLTKECQRTCN

30

37.5%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN+G +CTITKECQ CN

6

LSASLGNRGSYCTITKECQACCN

28

36.6%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide

Lanthipeptides: CN358_RS25180_lanthipeptide

12

DLCWLSRLGGNQGWFCTITKECQVNCN

38

D LS GN G+ CT T ECQ NCN

15

DYIKLSIGLGNNGYICTYTVECQKNCN

41

MIBiG 4.0 matches for C794_RS17980

37.5%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSNALGNNGGWCTLTKECQPNCN

30

25.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

21

GNQGWFCTITKECQVNCN

38

GN+G +CT+T EC +CN

11

GNKGAYCTLTVECMPSCN

28

22.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTITKECQVNCN

38

CT++KECQ NCN

28

CTLSKECQPNCN

39

Lanthipeptide(s) for C794_RS20015

C794_RS17975

Leader:

MDIIKNSSKRIEINTSFENHPAGEISEEELLAISGG

Core:

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

Core with dehydrations:

QVEQNDhaLDhaPLDhbPDhaDhaGDhaCysVAIDhaLAFCysPDhbDhaACysDhbDhaDCysDhbEW

antiSMASH-DB 4.0 matches for C794_RS17975

100.0%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17975_lanthipeptide

Lanthipeptides: C794_RS17975_lanthipeptide

1

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

37

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

1

QVEQNSLSPLTPSSGSCVAISLAFCPTSACTSDCTEW

37

41.0%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

8

SPLTPSSGSCVA----ISLAFCPTSACTSDC

34

+PLT SS CV IS CPT+ CTS C

9

TPLTTSSWPCVIGAVDISANLCPTTKCTSKC

39

40.5%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

11

TPSSGSC-VAISLAFCPTSACTSDC

34

TPSS +C +A+S FCPT+ CTS C

8

TPSSVACGIAVSALFCPTTKCTSQC

32

with 97 more sequence matches

Only the first 10 are displayed here.

40.5%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

17

CVAISLAFCPTSACTSDC

34

CV +SLAFCPT+ACTSDC

18

CVPVSLAFCPTTACTSDC

35

40.5%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

9

PLTPSSGSCVAISLAFCPTSACTSDC

34

P+T SS C S AFCP++ACTS C

3

PITTSSWICGVASAAFCPSTACTSKC

28

38.5%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

8

SPLTPSSGSCVAISLAF-----CPTSACTSDC

34

+P TP+ G V AF CPTSACT C

8

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

39

37.8%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

11

TPSSGSC-VAISLAFCPTSACTSDC

34

TPSS C V ++ AFCP++ CTS C

8

TPSSLPCGVFVTAAFCPSTKCTSSC

32

37.8%

NZ_CP036019.1and 7 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27190_lanthipeptide

8

SPLTPSSGSCVAISLAFCPTSACTSDC

34

+P TP+ VAIS+ CPT+ CTS C

8

TPATPTI--VVAISVGLCPTNRCTSKC

32

36.8%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20290_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07810_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08830_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11870_lanthipeptide

Lanthipeptides: BLI_RS20290_lanthipeptide

8

SPLTPSSGSC----VAISLAFCPTSACTSDC

34

+P T SS +C V +S + CPT+ CTS C

8

TPATTSSWTCITAGVTVSASLCPTTKCTSRC

38

35.9%

NZ_CP009288.1and 3 others:

NZ_CP009288.1 Lanthipeptides: PDUR_RS29295_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptideNZ_CP076607.1 Lanthipeptides: KP014_RS01575_lanthipeptide

Lanthipeptides: PDUR_RS29295_lanthipeptide

10

LTPSSGSC----VAISLAFCPTSACTSDC

34

LT SS +C V +S + CPT+ CTS C

11

LTTSSWTCITAGVTVSASLCPTTKCTSQC

39

35.1%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

11

TPSSGSCVAISLAFCPTSACTSDC

34

TP++ + VA+SL CPT+ CTS C

8

TPATPTIVAVSLGICPTTKCTSKC

31

35.1%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00915_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07475_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20090_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00915_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01010_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20270_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03665_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19045_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16135_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11925_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01510_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00070_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21810_lanthipeptide

Lanthipeptides: BALI_RS00915_lanthipeptide

11

TPSSGSC-VAISLAFCPTSACTSDC

34

TPSS C ++ +CP++ACTSDC

8

TPSSLPCGTLVTAVWCPSNACTSDC

32

35.1%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

8

SPLTPSSGSCVAISLAF----CPTSACTSDC

34

+P TP++ VA+S CPT+ACT C

2

TPATPATPVIVAVSAYVSDKTCPTTACTRAC

32

MIBiG 4.0 matches for C794_RS17975

35.1%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

LSPLTPSSGSCVAISLAFCPTSACTSDC

34

L + +G V +S AFCPT+ CTS C

10

LGIVAIQAGVAVGVSAAFCPTTKCTSRC

37

21.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

24

FCPTSACTSDC

34

FCPT+ CTS C

16

FCPTTKCTSKC

26

C794_RS17980

Leader:

MKEKVKAWKDPLARDVHTSHPSGDIFSEISDEEMYKLSGG

Core:

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

Core with dehydrations:

DhaAEDhbQDIDhbLPIDLCysWLDhaRLGGNQGWFCysDhbIDhbKECysQVNCysNVG

antiSMASH-DB 4.0 matches for C794_RS17980

100.0%

NZ_CM001792.1and 1 other:

NZ_CM001792.1 Lanthipeptides: C794_RS17980_lanthipeptide

Lanthipeptides: C794_RS17980_lanthipeptide

1

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

40

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

1

SAETQDITLPIDLCWLSRLGGNQGWFCTITKECQVNCNVG

40

41.5%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13060_lanthipeptide

Lanthipeptides: BUE45_RS13060_lanthipeptide

1

SAETQDITLPIDLC-WLSRLGGNQGWFCTITKECQV

35

+ T IT P+ C LSR N G FCT+T EC V

3

APNTISITNPLIACALLSR--NNTGRFCTVTVECNV

36

40.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GNQG +CT+TKECQ NCN

8

LSDFLGNQGGWCTLTKECQPNCN

30

with 117 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

15

WLSRLGGNQGWFCTITKECQVNCN

38

WLSR GN G+ CT+TKECQ CN

4

WLSRKLGNTGYVCTLTKECQRMCN

27

40.0%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide

Lanthipeptides: HBA49_RS00770_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LSRL GN G +CTITKEC +CN

1

LSRLLGNNGRWCTITKECMPSCN

23

40.0%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GNQG +CT+TKECQ NCN

8

LSDWLGNQGGWCTLTKECQPNCN

30

37.5%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

7

ITLPIDLCWLSRLG-GNQGWFCTITKECQVNCN

38

+ I C L +G GN GW CT T ECQ C

5

VAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

37.5%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSDALGNHGGWCTLTKECQANCN

30

37.5%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSDALGNSGGWCTLTKECQPNCN

30

37.5%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSDAVGNHGGWCTLTKECQPNCN

30

37.5%

NZ_JAJAGO010000028.1and 1 other:

NZ_JAJAGO010000028.1 Lanthipeptides: LHJ74_RS33590_lanthipeptide

Lanthipeptides: LHJ74_RS33590_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN GW+CT+TKECQ CN

8

LSDAAGNDGWWCTLTKECQRTCN

30

37.5%

NZ_KE384107.1:

Lanthipeptides: G586_RS23925_lanthipeptide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN+G +CTITKECQ CN

6

LSASLGNRGSYCTITKECQACCN

28

36.6%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25180_lanthipeptide

Lanthipeptides: CN358_RS25180_lanthipeptide

12

DLCWLSRLGGNQGWFCTITKECQVNCN

38

D LS GN G+ CT T ECQ NCN

15

DYIKLSIGLGNNGYICTYTVECQKNCN

41

MIBiG 4.0 matches for C794_RS17980

37.5%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

LSRLGGNQGWFCTITKECQVNCN

38

LS GN G +CT+TKECQ NCN

8

LSNALGNNGGWCTLTKECQPNCN

30

25.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

21

GNQGWFCTITKECQVNCN

38

GN+G +CT+T EC +CN

11

GNKGAYCTLTVECMPSCN

28

22.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTITKECQVNCN

38

CT++KECQ NCN

28

CTLSKECQPNCN

39

allorf_3556341_3556439

Leader:

MPCIAKKVEGRSILYL

Core:

GHWFFCPFSTLIHKEE

Core with dehydrations:

GHWFFCysPFDhaDhbLIHKEE

antiSMASH-DB 4.0 matches for allorf_3556341_3556439

100.0%

NZ_CM001792.1:

Lanthipeptides: allorf_3556341_3556439_lanthipeptide

1

GHWFFCPFSTLIHKEE

16

GHWFFCPFSTLIHKEE

1

GHWFFCPFSTLIHKEE

16

17.6%

NZ_GG666304.1:

Lanthipeptides: HMPREF0077_RS09155_lanthipeptide

6

CPFSTLI

12

CPF+TLI

26

CPFATLI

32

8.8%

NZ_CP045142.1:

Lanthipeptides: GBQ70_RS07075_lanthipeptide

1

GHWFFCPFSTLIHKEE

16

G F+C T +H+ E

36

GSTFYCDTPTRLHRHE

51

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

C794_RS18000: T1TS

Domain 1 (15 - 307): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.76 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.77 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.90 out of 27.78

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.30 out of 36.53

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 26.85

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19

Confidence: medium

Additional weak hits (1):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

Lanthipeptides

Terpene

TFBS Finder

Core peptide predictions

C794_RS17975 - Class II

Cleavage pHMM score: -0.20

RODEO score: 0

Monoisotopic mass: 3602.7 Da

Molecular weight: 3605.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3623.0 Da N = 1; 3641.0 Da N = 2; 3659.0 Da N = 3; 3677.0 Da N = 4; 3695.1 Da N = 5; 3713.1 Da N = 6; 3731.1 Da N = 7; 3749.1 Da N = 8

C794_RS17980 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 4304.1 Da

Molecular weight: 4306.9 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4324.9 Da N = 1; 4342.9 Da N = 2

allorf_3556341_3556439 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 1940.9 Da

Molecular weight: 1942.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1960.2 Da N = 1

C794_RS17975 - Class II

Cleavage pHMM score: -0.20

RODEO score: 0

Monoisotopic mass: 3602.7 Da

Molecular weight: 3605.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3623.0 Da N = 1; 3641.0 Da N = 2; 3659.0 Da N = 3; 3677.0 Da N = 4; 3695.1 Da N = 5; 3713.1 Da N = 6; 3731.1 Da N = 7; 3749.1 Da N = 8

C794_RS17980 - Class II

Cleavage pHMM score: -4.00

RODEO score: 0

Monoisotopic mass: 4304.1 Da

Molecular weight: 4306.9 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 4324.9 Da N = 1; 4342.9 Da N = 2

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
DmdR1	Iron(II)-dependent repressor
MogR	Repressor of flagellar motility genes
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor