LOCUS       NZ_CM001792            12157 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Oceanobacillus kimchii X50 chromosome, whole genome shotgun
            sequence.
ACCESSION   NZ_CM001792
VERSION     NZ_CM001792.1
KEYWORDS    WGS; RefSeq.
SOURCE      Oceanobacillus kimchii X50
  ORGANISM  Oceanobacillus kimchii X50
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Oceanobacillus.
REFERENCE   1  (bases 1 to 3830781)
  AUTHORS   Kim,J.Y. and Bae,J.-W.
  TITLE     Genome Sequence of Oceanobacillus kimchii X50T, Isolated from
            Traditional Korean Fermented Food
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 3830781)
  AUTHORS   Kim,J.Y. and Bae,J.-W.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-OCT-2012) Department of Life and Nanopharmaceutical
            Sciences and Department of Biology, Kyung Hee University, HoeGi-Dong
            1, DongDaeMun-Gu, Seoul 130-701, Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method :: GS De Novo Assembler v. 2.6; CLC NGS Cell v. 5.0
            Genome Coverage                   :: 267.13x
            Sequencing Technology             :: 454; Illumina GAIIx; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000340475.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 09:35:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,833
            CDSs (total)                      :: 3,769
            Genes (coding)                    :: 3,736
            CDSs (with protein)               :: 3,736
            Genes (RNA)                       :: 64
            rRNAs                             :: 4, 2, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 2, 4 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 33
            CDSs (without protein)            :: 33
            Pseudo Genes (ambiguous residues) :: 0 of 33
            Pseudo Genes (frameshifted)       :: 16 of 33
            Pseudo Genes (incomplete)         :: 18 of 33
            Pseudo Genes (internal stop)      :: 8 of 33
            Pseudo Genes (multiple problems)  :: 7 of 33
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:23:04
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 608070
            Orig. end                         :: 620227
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM001792.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Jin-Woo Bae, Kyung Hee
            University, HoeGi-Dong 1, DongDaeMun-Gu, Seoul 130-701, Korea.
FEATURES             Location/Qualifiers
     region          1..12157
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..12157
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..12157
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:7157](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7157
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            698..1387
                     /locus_tag="C794_RS03405"
     CDS             698..1387
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C794_RS03405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_017795738.1"
                     /transl_table=11
                     /translation="MDPVNYIKDMLGITEETVIDKAMDVSLGTAPLIGKVYQSFQMLKL
                     QKRMQTNIQQLQTLKNKIESNENEVFYKQEVFPLIFKKLFEEDEDIKASVVIGGFEYII
                     DHGINEIETIYHYYDVLAELRFSDIIILVEDFMPYEMRKNPSLKINFPTNEEMRSNKYK
                     EQQTINTYQKNKMVRLGLLENRVDNIDGEDYKGKSLIKEEIIITDFGKRFLILFALDEA
                     SEKREFT"
     gene            1645..3366
                     /locus_tag="C794_RS03410"
     CDS             1645..3366
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012376.4"
                     /locus_tag="C794_RS03410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_017795739.1"
                     /transl_table=11
                     /translation="MKSNKIESSLIVAKKHIPFIATKTEDVLPSEFVARFELYPENKRR
                     PVNKILFRNDYFQLTYSMKKKDLVISSRGDIVYSAIPYDTARNYIQRATIQYLLHPEEV
                     REYIKMHKGNLEKYIMLSIFQVTKKRVDKNSFEVKQAYNAIFQDPLFEIQILGRLLQHD
                     ETGPISANLAGKFLFSENVYTGISEYIFEYLNFVVQLTKSLPIRTDGKSVKLLETNLLK
                     RSFTNNRTKNQFLTNKSDIKLALSIIPQVEKVNTENPIVIAKQSLHLNDKPILRSRSGE
                     EISQFRKKYIPHSVHPKEAEKYFENVLSTENTNLLNVVSDVHTMDGKLPFVNKNFNILV
                     GDISDSRVTNEDIKGIYVIGNHELVDVLPDNNNIEELQGKKWSPFLNSEWFKQLLENPD
                     ESWYMLPVGNHKFYEVVKVELEKRFPQLNVLHNNHIVHEGVRYIGLTIPVALVKRKKEQ
                     QKFILKSLKKLLNNDYDIPTIIVSHAPLFNELSMLSIKSKAYNKDYNLSEPKIEKLFKE
                     YNIIGAIHGHHHIPASSGQSKIVKFASKELFVVCSIYSKMNTGFELMNLINPKLTN"
     gene            4188..4394
                     /locus_tag="C794_RS03415"
     CDS             4188..4394
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017795741.1"
                     /locus_tag="C794_RS03415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017795740.1"
                     /transl_table=11
                     /translation="MGNLECLDNSYTELSSEDMYDVSGGLAITIAGVTLVITAKGLGML
                     AGIIGGTYSIGYAIGQGWAYIKK"
     gene            4420..4626
                     /locus_tag="C794_RS03420"
     CDS             4420..4626
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="C794_RS03420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_017795741.1"
                     /transl_table=11
                     /translation="MAEVMKFDQLNNELSLEEMYDCNGGLAITIMGVTFVGWKAAAIIA
                     SGVTTLAGVAGLGFWNGYNGTKK"
     gene            5001..7157
                     /locus_tag="C794_RS03430"
     CDS             5001..7157
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0043214 - ABC-type bacteriocin transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0043213 - bacteriocin transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01193.1"
                     /locus_tag="C794_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide cleavage/export ABC transporter"
                     /protein_id="WP_017795743.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 8.3e-40, bitscore:
                     133.5, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5.8e-244, bitscore:
                     809.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKKYKYVKQKDQKDCGPASIATVLKQYNSNVSIAKIREVSGTS
                     DTGTNALGIVKGLEYFNFKVKSIKADMNIFKEKDLPYPAIAHIVKDKLLLHFIVILNVG
                     KKKITIADPSEGVKKLTYEEFEEMWTGVVFFCLPNDNYEMVKDKNEQLEQIFKMIISDK
                     KLITHIILASILVILIGIGTSFYFQTIIDSIIPSGAEKTLHIISIALIVSYIFQSLFEY
                     IKNYMLAVLGNRMSIKVMLGYYRHVMNLPMNFFATRKSGEIVSRFMDASKVIDALGSVV
                     LTSIIDVSMVLIVGAVLYFQNQTLFFVTVLTIPIYALIILSFIKWYEKANKQELQDNAH
                     LNSYIIESLNGIETIKASQADESSVRKVDNLFLVYINSMMRTFNIDNLQTLLKRMIQLV
                     STGVILWIGATLVLDNELSIGQLITFNSLLVYFTDPLLNIINLQPRLQTAKVAAERLND
                     VMIIDSEMEENENKKISNDIIFDGDIELKDVSFNYPTRREVLKNINISISSAEKIAIVG
                     KSGSGKSTLAKLLVSFYNTTKGEILFNKYNIEDVDKNYLRKKITLVPQKPFFFSGTIYE
                     NLTFGIDRDVNLEEIVEVCKKVQIHEFISSLPLRYNSYLEENGDNFSGGQQQRLALARA
                     LLRKSKVIILDEATSNVDQFTEKKIMNEILNDKDLTIIIIAHRLSILTNCDSIYVIKDN
                     IIAENGTHKELIEKGGLYYDMWNI"
     gene            7173..8249
                     /locus_tag="C794_RS03435"
     CDS             7173..8249
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024829.4"
                     /locus_tag="C794_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="biotin/lipoyl-binding protein"
                     /protein_id="WP_017795744.1"
                     /transl_table=11
                     /translation="MVDINSIKVESEIYKKKYSKTGLIIIYPFLIFIVVLLLFLFLADK
                     EVYIEVPSSVNTYSSSTDIKSKVEGVVQSINVKNGDYVEAGDIIMEIDSQETKEEIKNI
                     EQEIDRLNIEKSNIDNFKKSVVEKSNYLSEDNIEFQIMYNNYIIQTEKITLENRILTHK
                     IEEVSNESIVEEYRLQQEINNKSQQELKYQLLIDSFQKEKNIIEKIDESLNTLSELESR
                     RNNMILKSDDSGYVQFNNQVSIGSQIMAGDDLYTITTNDKSELYIQGLVSTDKISALNK
                     GQKANFSIQNSIDKETNIVESEIINIGKTPVTTEEGNYYIIETDIIENDNLTLGMTGNL
                     NIITDTVTYLDYFWNKLF"
     tRNA            8364..8461
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="C794_RS20620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-OTHER"
     gene            8364..8461
                     /locus_tag="C794_RS20620"
     gene            complement(8714..9628)
                     /locus_tag="C794_RS03440"
     CDS             complement(8714..9628)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016821117.1"
                     /locus_tag="C794_RS03440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_017795745.1"
                     /transl_table=11
                     /translation="MKINESSLTSLIAAFGRAYHSQFDTPKIFNDYLAKDLFSQKEFND
                     IKANMVQGIQFFNKEIAQKFKDDTDEILKWITQVQLSPTPLARAAYCEKVLLNEVRLGL
                     KQYVILGAGLDTFCFRHPEMKNKLEIFEIDHPSTQEFKKKKLDQARFKIPSNLHFIPMD
                     FTKKFSYQSLIEEELDNHRTFFSLLGVSYYLTKEEIANLVDKLFTKIPSGSSIVFDYAD
                     EKLFKEKGMSNRVQNMVQMASASGEPMKSCFTYDEIEGLLENAGLLIYEHLSPVTINNR
                     FFHNRNDYLSAFETIHYIHAVKK"
     misc_feature    9599..9617
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.55"
                     /tool="antismash"
     misc_feature    9665..9679
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(9674..9688)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(9765..9783)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.61"
                     /tool="antismash"
     gene            complement(9907..10323)
                     /locus_tag="C794_RS03445"
     CDS             complement(9907..10323)
                     /GO_process="GO:0030638 - polyketide metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018932947.1"
                     /locus_tag="C794_RS03445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ester cyclase"
                     /protein_id="WP_017795746.1"
                     /sec_met_domain="PF07366 (E-value: 2.4e-18, bitscore: 63.9,
                     seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGKEIYQNWMDAWNKDISFLNQITDENCVVHQARTDGKDSGSTK
                     GLNALKDVIESAKDYFENVKMSLVVEPIEDGNYVSARWNFKGVYNGKMEEAKAERGKLV
                     SFDGTDIFYIENNKIKEYWVSSDVIDFMNQLEVF"
     misc_feature    10740..10755
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            10761..11210
                     /locus_tag="C794_RS03450"
     CDS             10761..11210
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003226084.1"
                     /locus_tag="C794_RS03450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1569 domain-containing protein"
                     /protein_id="WP_017795747.1"
                     /transl_table=11
                     /translation="MKNIFNQLHAEEIINRIDNLNSSSKPQWGKMDVAKMLAHCSSFQD
                     IAMGNAFPSRGWLGILIGKFAKPIFYNDKPLARNMSTIPTILILDEKEFETEKEKLKQK
                     ILTFQNNGPQKCTNHPHPFFGKLTSEQWGKGIYKHLDHHLKQFGV"
     gene            11346..11951
                     /locus_tag="C794_RS03455"
     CDS             11346..11951
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428533.1"
                     /locus_tag="C794_RS03455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dienelactone hydrolase family protein"
                     /protein_id="WP_017795748.1"
                     /transl_table=11
                     /translation="MIQLHKNSDTVIIVIHEIYGINQHIESFCKLLSKFSFDVICPNLL
                     QQDTPYDYSEEEVAYRNFMENVGFTDASQKIKDIVSDVTDNYRKIFIIGFSVGATVAWL
                     CSEEESVNGIVGYYGSRIRNYVELTPKCPTTLFFPQEESSFNVDELISTLDNKNIEAHK
                     FNGRHGFSDPYSPKYNEISAQKAFDEVVDFIIKQMGCY"
ORIGIN
        1 gttttggcaa gacttattaa aagaacatac atggatatta agtcagttat tttcgaaccc
       61 tactgtatta attgataatg aagtatatgt tggagggaaa acaactagca atgataatgg
      121 taagttagtt gatttcttgt atgctaaccc tttttctaaa gatgctgttt tgattgaaat
      181 caaaacacca acaactccac taattaataa tgctcagtat agaacagggg tatactcagc
      241 ccataaagag cttataggtg ctattaccca agttctaaca tacaaaggtg ctctacagaa
      301 agaatactca aatatacttg ttaacaatat taataatggt agaaatacag aatttgatgt
      361 aattaatcct atttgtgtag tcatagcagg taggtttgat aatttaaaag aaataagtca
      421 taaacattca tttgaactat atagaaaaga actgaaaaca gtaatagtaa taacatttga
      481 tgagttattt aagaaagttg aaaatttgat agatttatta gaaaaataaa tgaaaacgta
      541 ttttttgata tttactctaa tagaaataat acaaatttgt ccaatcaaac atttataaat
      601 gagttatatg tatctaaact gtaaaagttt aaatccttct ctattgcatc ttcactgaat
      661 aatggtttat agaaaatcta gaaaggtttg tgatggtttg gatccagtta attatattaa
      721 agacatgtta ggaataacag aagaaacagt tatagataaa gcaatggatg ttagtctagg
      781 aacagcacca ttaatcggaa aagtttatca gtctttccag atgttaaaac ttcaaaaaag
      841 gatgcaaaca aatatacaac aattacaaac acttaaaaat aaaattgagt caaatgagaa
      901 tgaagttttt tataagcaag aagttttccc acttatattt aaaaaacttt ttgaggaaga
      961 tgaagatatt aaagcatcag ttgttatcgg tggttttgaa tacataattg accatggtat
     1021 aaatgagatt gaaacaatct atcattatta tgatgtttta gctgaattaa ggtttagcga
     1081 tataataata ttagttgaag attttatgcc atatgaaatg agaaagaatc cttcattaaa
     1141 aataaatttt ccaacaaatg aagaaatgcg ttctaacaaa tacaaggagc aacaaacgat
     1201 caatacttat caaaaaaata aaatggttcg attgggactt ttagagaata gagtcgataa
     1261 tatagatggt gaagattata aaggcaagag tttaattaaa gaagaaatta ttattactga
     1321 ttttggaaaa cgttttttaa tactttttgc attagatgaa gcatctgaga aacgagaatt
     1381 tacttgaaaa gttgaattat gttacggaaa gacgaaaata tagatgttat cgaaaaaata
     1441 caaaattgtt ggcatgaaat gcggtcaaaa aagacttgta actgtataac aagctatctc
     1501 aatattgagg gcttagtgaa ttattgtgat catccttgct ttgtaaatat tcaaatagtt
     1561 ttttacttta tataatgaaa aaatgatgta cttaaactaa tggggcagga tagtgcaaga
     1621 gtcagttatt aatgaggtga ttttatgaaa tctaataaaa tagaaagttc tttaatcgtc
     1681 gctaaaaagc atatcccttt tatagcaaca aaaactgagg atgtactacc gtcagaattt
     1741 gttgcacgtt tcgaacttta tccagaaaat aaacgaagac ctgtcaacaa aattttgttt
     1801 agaaacgatt actttcaatt gacatatagt atgaagaaaa aagatttggt tatatcgtcc
     1861 agaggagata ttgtctattc agctattcct tatgatacag ctaggaacta tatccaacgt
     1921 gcaactatac agtacttact ccatccagaa gaggtacgag agtatattaa aatgcataaa
     1981 ggtaatttag aaaaatacat tatgcttagt atttttcaag tcacaaaaaa acgtgttgat
     2041 aaaaactctt ttgaagttaa acaagcttat aatgcaatat ttcaagatcc attatttgag
     2101 attcaaattc ttgggcgact actgcaacat gatgaaactg ggccgatttc tgcaaatcta
     2161 gcaggtaagt tcttgtttag tgagaatgta tacacaggaa tatctgagta tattttcgaa
     2221 tatcttaact ttgtcgttca acttactaaa tctttaccaa taagaactga tggaaaaagt
     2281 gttaaattat tagaaacaaa tcttttaaag cgatctttta ccaataatag aactaagaat
     2341 cagtttttaa ccaataaatc agatataaaa ctagcattga gtataatacc tcaagtagaa
     2401 aaggtaaata cagaaaatcc aatcgtgatt gccaaacagt ccttgcattt aaatgataag
     2461 ccgattttac gatccaggtc aggggaagaa atttctcaat ttagaaaaaa atatattccg
     2521 catagtgttc atcctaaaga agcagaaaaa tattttgaaa atgttctttc aacagagaat
     2581 acaaatttat tgaatgttgt ttctgatgtc cacactatgg acgggaagct tccattcgtt
     2641 aacaagaatt tcaatatatt ggtaggggat atttcagatt ctcgtgtaac aaacgaagat
     2701 attaaaggta tttatgtaat tggaaatcat gaattagtag atgtattgcc ggataataat
     2761 aatatagaag aactgcaagg aaagaaatgg agtccatttt tgaatagtga atggtttaaa
     2821 caacttttag aaaatcctga tgagtcatgg tacatgttgc ctgtgggtaa ccataaattt
     2881 tacgaggtag taaaggttga acttgaaaaa agatttccac aattaaacgt attacataac
     2941 aatcatatag ttcatgaagg agtccgatat atcggactta caatacctgt tgctttagtt
     3001 aagagaaaga aagagcaaca aaaatttatt cttaaatcat taaaaaaatt actaaacaac
     3061 gattatgata ttccaacaat aatagtctca catgcgccac tatttaatga actgagtatg
     3121 ctttcaataa aaagtaaagc gtataataag gattacaatt tgtccgaacc taaaattgaa
     3181 aaattattta aggaatataa tataatcgga gccatacatg gccatcacca tataccagcg
     3241 tcatctggcc aaagcaaaat tgtgaaattt gcaagcaaag agctatttgt ggtgtgctca
     3301 atttattcta aaatgaatac aggattcgag ttaatgaatc tgataaatcc taagttaacg
     3361 aactaagaaa ttcaatcaat agaataacgt gtgctttaat tgaagaaagt tataaaaaca
     3421 aaaatcttat tgtgaaaaga cgaatgttag aaggtattta ttgaatattg ttcgtatatg
     3481 agttttatca aaaatgacca ataattaacc aaaataaatt aaagtataga ataaaataaa
     3541 aaactaataa cataaaatgc gatcaaatag aggatttata ccctattata agttctctcc
     3601 atattgaggg cttagtggga aataatcccg tggaggttca aatcctctcg accgcatttt
     3661 tatacgaaag cagtgatacc aatggatgaa gttccattgg tatttttttg tatctatatt
     3721 gtttgtaaat aactttagtg ttactaaaat attcaccaat tgctaaaaca agctatcaag
     3781 ttgctcagca gtttttcgtg tttgttcaaa aataaatgac catatacatc tatagtcgtt
     3841 ttaatagaaa catgtcctga tatacaagta agtctcattg tgattttagt gattaataat
     3901 gaataggagg aatactctaa aacatataac ataagaaaaa tattactaat gaactaagtt
     3961 ttattggtat tttagattta tcttatttaa attgagcatt ataatttgat attttcctag
     4021 tttttcataa aatagtattt ttatactagt ttattagaga ttaattttcc tttttatccc
     4081 atttaaggaa actattgcaa atatattcat agtattatat gcttatttta gacatatttc
     4141 taaatatttg gttttatgtc taaattaaaa agaaaagagg tgttaaaatg ggtaatttgg
     4201 aatgcttaga taactcttat actgaattgt caagcgagga tatgtatgat gtatctggtg
     4261 gactagcaat tactatagcg ggtgttactc ttgtaattac tgctaaaggg ctaggaatgt
     4321 tagcaggtat aattggtggt acgtattcta ttggttacgc aataggtcaa ggatgggctt
     4381 atatcaaaaa gtaaaaaaag atgagaggag tttttggtta tggcagaagt aatgaagttt
     4441 gatcaattga ataatgagtt atcattagaa gaaatgtatg attgtaatgg tggactagca
     4501 attaccatta tgggggtaac ctttgtgggg tggaaagcag ctgctattat tgcctctggt
     4561 gttacaactt tagctggtgt agctggatta ggtttttgga atggctacaa cggtactaaa
     4621 aaataatttt agattatttg aaaaataata gtagaaagta atatcctact aggaggattt
     4681 cattatgctt gagattttcg gcaaagaatt caagttagat attttaatat tctcatttat
     4741 ttttatactt agtttaggta ttatctcttt gaatttatta tacttcttta aatttaattc
     4801 gagtttaatt aatttaaata tgggagcagg cttaattttg cttatctatt caagttataa
     4861 attatttatt aaaggataac tagggaaaaa tatttatttg aatttattag agtggattat
     4921 caaacttgct gaaatgagaa gttgataatc cacttttatt atcattttta ttaaaatgta
     4981 attcaatctt gggggacaaa atgaaattaa aaaaatataa atatgtaaag caaaaagatc
     5041 aaaaagactg tggtccagct agtattgcaa cagttctaaa acaatataac tctaatgtaa
     5101 gtattgcaaa aataagagaa gtgtcgggaa cttctgatac aggaactaat gcattaggga
     5161 ttgtaaaagg gttggagtat tttaatttta aggtaaaatc cataaaagct gatatgaata
     5221 tctttaaaga gaaagattta ccttatcctg ctattgctca catagttaaa gataaactat
     5281 tacttcattt tattgttatt ttaaatgttg gaaagaaaaa aataacaata gcggacccaa
     5341 gtgagggagt taagaagtta acctatgaag aatttgaaga aatgtggaca ggagttgtat
     5401 ttttctgtct tccaaatgat aactatgaaa tggtaaaaga taaaaatgaa caattagagc
     5461 aaatttttaa aatgattatt agtgataaaa aattaataac ccatataata ctagcttcta
     5521 tacttgttat tttaattggg ataggaactt ctttttactt tcaaactatt attgactcaa
     5581 taattccttc aggtgctgaa aaaacactac atattatatc tattgcactt atagtatcat
     5641 atatttttca gtctctattt gaatatataa agaattatat gctcgcagta ttaggaaata
     5701 ggatgagtat caaagtaatg ttgggttatt ataggcatgt aatgaattta ccaatgaatt
     5761 tttttgctac tagaaaatcg ggcgaaatag tttcaaggtt tatggatgct agtaaagtta
     5821 tagatgcttt gggtagtgtt gttcttacga gtattattga tgtttctatg gtactaattg
     5881 ttggtgcagt tctttacttt caaaatcaaa ctttattttt cgttaccgtt ttaacaattc
     5941 ccatatatgc cttaataatt ttatcgttta taaaatggta tgagaaagct aacaaacaag
     6001 aattacaaga taatgcacat ttaaattcat atataattga gtcattaaac ggtatagaga
     6061 caattaaagc ttcacaagct gatgaatcat cagtacgtaa agtagacaat ttatttttag
     6121 tatacataaa ttctatgatg agaactttta atatagataa tctacaaaca ctattaaaga
     6181 gaatgattca gttagtaagt acgggagtta tattatggat aggtgctaca ctagttttag
     6241 ataatgaact ttctattggt cagttgataa catttaattc tttattggtg tattttactg
     6301 acccattgtt aaatataata aatttacagc ctaggttgca aacagcaaaa gttgctgcag
     6361 aaaggcttaa tgatgtgatg ataattgatt cagaaatgga agaaaacgaa aataaaaaaa
     6421 tttcaaatga tattatattt gatggggata ttgaattaaa agatgtatcc tttaattatc
     6481 ctacaagaag agaagtatta aaaaatataa acattagtat aagttcagct gaaaaaattg
     6541 ctatcgtagg taaaagtggt tctggaaagt ctacgttagc aaaattatta gtttcttttt
     6601 ataacacaac caaaggagaa atattgttta ataaatacaa tattgaggat gttgataaaa
     6661 actatctgag aaaaaaaata acgttagtac ctcaaaaacc cttttttttc agtggtacaa
     6721 tctatgaaaa tcttaccttt ggtattgaca gagatgttaa cttagaagag attgttgaag
     6781 tgtgtaaaaa agttcaaatt catgaattta tatctagtct tcctttaaga tataattctt
     6841 atcttgaaga gaatggagat aatttctctg gtggtcaaca acaacgttta gctttagcta
     6901 gagctttgtt aagaaaatct aaggttatta ttttggacga agcaactagt aacgtggatc
     6961 aattcactga aaaaaagata atgaacgaaa tattaaatga taaagatttg acgattataa
     7021 taatagcaca caggctttct atattaacaa actgtgattc tatttatgtt attaaggaca
     7081 atattattgc tgagaatgga actcataagg aattaataga aaaaggtggt ttatattatg
     7141 acatgtggaa tatttaatag gtggggtata acatggttga tataaactct attaaagtag
     7201 aaagtgagat atataaaaaa aaatatagca aaaccggatt aattataatc tatccttttt
     7261 taatttttat agtagtttta ttattatttt tatttttagc tgataaagaa gtttatatag
     7321 aagtaccaag tagtgtgaac acttatagtt ctagtacaga tattaaatca aaagtagaag
     7381 gggtggttca atcaattaat gttaaaaatg gagattatgt agaagctggg gatataatta
     7441 tggaaataga ttctcaggaa actaaagaag aaataaaaaa tattgaacag gaaatagatc
     7501 gattaaatat agaaaagagt aatattgata attttaaaaa aagtgtagtt gagaaatcaa
     7561 actatttatc tgaagataac atagagtttc aaatcatgta taataattat ataatacaga
     7621 cagaaaaaat aacccttgaa aaccgtattt taactcataa aattgaagag gtttctaatg
     7681 agagtatagt tgaagaatat agacttcaac aagaaattaa taataaatct cagcaagagc
     7741 taaaatatca attgttaata gactcatttc aaaaagaaaa aaatattata gaaaagattg
     7801 atgaaagttt aaatacatta agtgaacttg aatcaagaag aaataatatg attttaaaga
     7861 gtgatgacag tggctatgtt caatttaata atcaagtttc aattggttct cagattatgg
     7921 ccggagatga tttgtataca ataacaacta atgataaatc cgaactatat atacaggggt
     7981 tagtatctac agataaaatt agtgcattga ataaagggca aaaagcaaat ttctcaattc
     8041 aaaatagtat tgataaagaa actaatattg tagaaagtga aattataaat attggtaaaa
     8101 cacctgtaac aactgaagaa ggtaattatt atataataga gacggatatt atagagaatg
     8161 ataacctaac tttaggcatg acaggtaatt taaatataat aactgatacc gttacttatt
     8221 tagattattt ttggaataaa ttattttaga aaacacgaat aatttttgtt ataaattgtt
     8281 ttatgttcgg ttaattgatt gtccacatat ataccaaaat ataaataaaa acgtattaaa
     8341 ttatataaaa tgggttaata gatgcggtca aataaaggat ttgcaacgta ttataaggtc
     8401 tctcaatatt gagggcctag tgggcgtata gcccgtgtgg gttcaaatcc cactgaccgc
     8461 atctaaatat gaaatcagtg ataccaatgg atgaagatct gttggtgttt tttgtattgg
     8521 aaataggtga ctatacacat ctattgttgt tttaatatag aagtgccctt ggtaatcggg
     8581 gaggaaaaga tggagatctt ttagcgtagc gattcttttt gataagaaag aatagtatct
     8641 gaacataata gataaaaact cacctcccaa tcataagaga gattaggaag taagtttttt
     8701 attaactgat atattatttt tttacagcat ggatgtaatg aatcgtttcg aaagcagaca
     8761 aatagtcatt gcgattatga aagaatcgat tattgatcgt aacaggtgat aaatgttcat
     8821 agataagtaa acctgcattt tctaacaatc cctctatttc atcataagta aaacatgatt
     8881 tcattggctc accactagct gaagccattt gaaccatatt ttgcactcga ttagacattc
     8941 ctttttcttt aaaaagtttt tcatctgcat aatcaaaaac aatagaactt ccagatggaa
     9001 ttttagtgaa taatttatca accaagttgg caatttcctc ttttgttaaa taataagaaa
     9061 cacctaaaag actaaagaaa gttctatgat tatcaagctc ttcctctatt aggctttgat
     9121 aggaaaactt tttggtaaag tccataggaa taaaatgaag attactagga attttgaacc
     9181 tagcttgatc cagttttttc tttttaaatt cctgagtact tggatgatca atttcaaata
     9241 tttctaattt gtttttcatt tctggatggc ggaaacaaaa agtatctaat ccggcaccaa
     9301 gtatgacata ttgctttaaa cctagcctga cttcattaag taatactttt tcacaatacg
     9361 cagctcgtgc caaaggtgtt ggagaaagtt gaacctgagt aatccatttt agtatttcgt
     9421 ctgtatcatc tttaaatttt tgtgcgattt ctttgttgaa gaactgtatg ccttgaacca
     9481 tattggcttt gatgtcgtta aattcttttt gtgaaaataa atctttagct aaataatcat
     9541 taaaaatctt aggtgtatca aattgactat gataagctct accgaaagct gctattaatg
     9601 atgttaagct cgactcattt attttcatat cacaccactc cttcaattta aagaaataaa
     9661 aataggattc tcctggccag gagaatccta ttatataatg taatgtataa aaagtaaatt
     9721 atagcacaaa ataattattt tgtcaaatga tataatcgtt gttatttaag aatcaatagc
     9781 aattgttgaa gaacatatca aaaaaatgtt caaacttttt taataaaaat tatatgaatt
     9841 catacggaaa aagccatttt gatcaatctt tcaaaagagt tatttgagtt ttctactaaa
     9901 acttctctaa aaaacttcta gttggttcat aaaatctata acgtcagagg aaacccaata
     9961 ttctttaatt ttattatttt caatatagaa aatatcggtt ccatcaaagg aaactaactt
    10021 tcctctttct gcttttgctt cttccatttt accattataa acacctttaa aattccaccg
    10081 tgcagagaca taatttccat cttctatagg ttcaactaca agtgacattt tcacattttc
    10141 aaaatagtct ttagctgatt caataacatc tttcaaagca tttaaccctt ttgtactacc
    10201 tgaatcttta ccatcagttc tagcttgatg aactacacaa ttttcatctg taatttgatt
    10261 aagaaaagat atatctttgt tccaagcatc catccaattt tgatatattt cttttccgtt
    10321 cataaacgaa ctcctttctc tcttttatat catagatttt ttgatatctg agtcttacta
    10381 ccctttttag cattattcat aacattaatc aactaatcaa tctttacata ttaggcatac
    10441 acttatattt cctttgtgtt ttattctttt aatgcgtagt acctttatgt aggttgaggg
    10501 cttactggga attaatccag tggagatcca aaatactttc gacagtattt atatataaag
    10561 cgagtaaaat caatggattg aatctactga tttttgttat tgtgattatc ccatattttt
    10621 aaatattcaa atatattttt gctttgatat aatgataata tgaagtaaaa aatgtgaaat
    10681 agtgtactta aactaaaggg gcaggatagt tcaataatca attgtatata tgttaatcaa
    10741 tatgccaagg ggggacaata ttgaaaaata tttttaatca attgcatgca gaggaaatta
    10801 taaatcgtat tgataattta aactcatctt caaaaccgca atggggtaaa atggatgttg
    10861 ccaaaatgct tgcacattgc tcatcttttc aagacattgc aatgggaaac gcttttcctt
    10921 cgagaggttg gttggggata ttaattggaa agtttgcgaa accaattttt tataacgaca
    10981 agccattagc tcgaaacatg tccacaatcc ctactatttt gattctagac gaaaaagaat
    11041 ttgaaacaga aaaagaaaaa ctaaaacaaa agattctaac attccaaaat aatggccctc
    11101 aaaagtgtac aaatcaccca catccttttt tcggtaaact tacttcggag caatggggaa
    11161 aagggattta taagcacctt gaccatcact tgaagcagtt tggtgtttag ttagccgaag
    11221 tgaagatttt ttactaacgg gtaggagtgt acaataagag tatacccttc tttttctatt
    11281 gggcagtttt gttgaagaag aactgaaata tgtataacaa aagtattaag gcaaaggagg
    11341 gggaaatgat tcaactacat aaaaattctg atactgttat cattgtaata catgaaattt
    11401 atgggattaa tcaacatatt gagagttttt gtaagttatt atcaaaattc agttttgatg
    11461 taatttgccc aaatctatta caacaagaca caccttatga ttattctgaa gaggaagttg
    11521 cttatcggaa ctttatggaa aacgtaggat tcactgacgc ttcacaaaaa ataaaagata
    11581 tagtttcaga tgttacagat aactatcgaa aaatatttat cattggattt agtgtagggg
    11641 caactgttgc ttggttgtgt agtgaggaag aaagtgtgaa tggaatagtt ggatattatg
    11701 gttcacgtat taggaattat gtagagttaa caccaaaatg tcccacaact ttattctttc
    11761 cccaagaaga gtcatcattt aatgtcgatg aattaatttc aactctagat aacaaaaata
    11821 tcgaggcgca taagtttaat ggaagacatg gatttagtga cccttactct ccaaaatata
    11881 atgaaatatc agcccaaaag gcgtttgatg aagtggtaga ttttattata aaacaaatgg
    11941 gttgctatta agtaatcagc gaaagagttg aaaaagggaa tgctgtggcg ggggcagttt
    12001 tgttgaagtg gaggagttta atgaaaagaa agtttccaat agtgattgca attgctgcgg
    12061 tttcaggcga gggaaaaaaa caattgactc ttaaagaggt ttagggatat ttctgtgctg
    12121 actttaatta acgataaaga ttatgaagaa ggattag
//
