GCF_000332075.2 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_ALVU02000001.1 (Synechocystis sp. PCC 7509)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene	328,976	349,902
Region 1.2	terpene-precursor	1,039,331	1,060,257
Region 1.3	NRPS-like	1,895,371	1,939,828
Region 1.4	NRP-metallophore,NRPS,T1PKS	2,050,177	2,131,464	Low	anachelin	NRPS:Type I+PKS
Region 1.5	NRPS	3,666,325	3,718,032	Low	desmamide A/desmamide B/desmamide C	NRPS:Type I+PKS

NZ_ALVU02000002.1 (Synechocystis sp. PCC 7509)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	lanthipeptide-class-ii	56,886	86,090

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene	328,976	349,902
Region 1.2	terpene-precursor	1,039,331	1,060,257
Region 1.3	NRPS-like	1,895,371	1,939,828
Region 1.4	NRP-metallophore,NRPS,T1PKS	2,050,177	2,131,464	Low	anachelin	NRPS:Type I+PKS
Region 1.5	NRPS	3,666,325	3,718,032	Low	desmamide A/desmamide B/desmamide C	NRPS:Type I+PKS
Region 2.1	lanthipeptide-class-ii	56,886	86,090

No secondary metabolite regions were found in these records:: NZ_KI966369.1 (Synechocystis sp. PCC 7509); NZ_KI966370.1 (Synechocystis sp. PCC 7509)

Compact view

NZ_ALVU02000001.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 328,976 - 349,902 nt. (total: 20,927 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

SYN7509_RS0201790: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: glycosyltransferase

SYN7509_RS0201815: sugar transferase

smcogs: SMCOG1146: sugar transferase

SYN7509_RS0201820: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Lyases: dehydratase

SYN7509_RS0201805: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

SYN7509_RS0201810: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

SYN7509_RS0201825: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000772.5	0.50	saccharide	lipopolysaccharide	Brucella melitensis
BGC0000742.3	0.48	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.3	0.48	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000732.3	0.47	saccharide	capsular polysaccharide	Raoultella planticola
BGC0000733.3	0.46	saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000656.5	0.46	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000787.3	0.46	saccharide	O-antigen	Escherichia coli
BGC0000645.3	0.45	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000769.3	0.44	saccharide	glycopeptidolipid	Mycobacterium avium subsp. hominissuis A5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000772.5	0.50	saccharide	lipopolysaccharide	Brucella melitensis
BGC0000742.3	0.48	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.3	0.48	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000732.3	0.47	saccharide	capsular polysaccharide	Raoultella planticola
BGC0000733.3	0.46	saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000656.5	0.46	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000787.3	0.46	saccharide	O-antigen	Escherichia coli
BGC0000645.3	0.45	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000769.3	0.44	saccharide	glycopeptidolipid	Mycobacterium avium subsp. hominissuis A5

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

SYN7509_RS0201785: PT_phytoene_like

Domain 1 (17 - 306): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.47 out of 26.06

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.35 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.54 out of 26.06

Confidence: medium

Additional weak hits (1):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.56 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes

NZ_ALVU02000001.1 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 1,039,331 - 1,060,257 nt. (total: 20,927 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

SYN7509_RS0205355: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

SYN7509_RS0205405: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Ligases: synthetase

SYN7509_RS0205415: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.48	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.45	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000497.3	0.37	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.48	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.45	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000497.3	0.37	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

SYN7509_RS0205415: PT_FPPS_like

Domain 1 (44 - 308): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial or Geranylgeranyl diphosphate synthase or geranylfarnesyl diphosphate synthase, bacterial

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 28.19

Confidence: medium

Additional weak hits (2):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.92 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.47 out of 28.14

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_ALVU02000001.1 - Region 3 - NRPS-like

Download region GenBank file

Download region SVG

Location: 1,895,371 - 1,939,828 nt. (total: 44,458 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

SYN7509_RS0209840: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: kinase

SYN7509_RS0209810: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Lyases: dehydratase

SYN7509_RS0209820: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease

SYN7509_RS25555: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000357.5	0.61	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.60	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.62	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0001758.4	0.61	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000357.5	0.61	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.60	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.31 out of 18.16

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.12 out of 32.93

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.69 out of 35.63

Confidence: medium

Additional weak hits (6):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.57 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.90 out of 35.63

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.61 out of 30.11

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 3, location 1895370 - 1939828:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Gly)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SYN7509_RS0209820: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (57..458): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LSVTFDIAAPDLQAICTGEWNMYGPTETTVWSTV
Nearest Stachelhaus code(s):: Gly DILQIGMVWK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CatR	H2O2-responsive repressor
LexA variant 3	Repressor of DNA damage response
MexT	Global virulence regulator
NrtR	NAD synthesis repressor

NZ_ALVU02000001.1 - Region 4 - NRP-metallophore,NRPS,T1PKS

Download region GenBank file

Download region SVG

Location: 2,050,177 - 2,131,464 nt. (total: 81,288 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

SYN7509_RS0210650: Dioxygenase TauD/TfdA

smcogs: SMCOG1046: Dioxygenase TauD/TfdA

Transferases: aminotransferase

SYN7509_RS0210675: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Ligases: ligase synthase

SYN7509_RS0210625: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SYN7509_RS0210635: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SYN7509_RS0210640: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

SYN7509_RS0210645: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

SYN7509_RS0210655: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

SYN7509_RS0210670: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SYN7509_RS27600: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SYN7509_RS27605: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

SYN7509_RS27610: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	1.28	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000342.4	1.21	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	1.19	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001261.3	1.16	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	1.14	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	1.13	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	1.11	NRPS	HC-toxin	Alternaria jesenskae
BGC0001128.4	1.11	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.10	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	1.10	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.72	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.72	NRPS	enniatin	Fusarium equiseti
BGC0001261.3	0.72	NRPS	AM-toxin	Alternaria alternata
BGC0001050.5	0.71	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.71	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.45 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.96 out of 26.06

Confidence: medium

Additional weak hits (13):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.93 out of 24.78

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.02 out of 27.18

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.26 out of 29.65

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.42 out of 29.25

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.51 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.34 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.66 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.02 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.85 out of 30.98

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.42 out of 29.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.26 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 2050176 - 2131464:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - Ala) + (Me-ohmal) + (D-Asp) + (D-Ser) + (D-His) + (Orn) + (D-Gln) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SYN7509_RS0210625: NH2 - Ala

Search NORINE for peptide: strict or relaxed

CAL_domain (53..497): NH2

minowa: NH2

Prediction, score:

NH2: 169.8
Acetyl-CoA: 48.9
fatty_acid: 17.7
AHBA: 9.3
shikimic_acid: 1.2

AMP-binding (1156..1541): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: LWATFDLSVFEVNTNLAGEFNLYGPSEDTTYSTF
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS27600: mal

PKS_AT (522..799): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 154.2
inactive: 99.9
Methoxymalonyl-CoA: 60.5
Methylmalonyl-CoA: 60.1
Propionyl-CoA: 45.1
Ethylmalonyl-CoA: 42.2
2-Methylbutyryl-CoA: 31.3
Isobutyryl-CoA: 30.2
Benzoyl-CoA: 30.2
CHC-CoA: 27.2
fatty_acid: 20.6
Acetyl-CoA: 15.0
trans-1,2-CPDA: 10.8
3-Methylbutyryl-CoA: 8.9

SYN7509_RS0210640: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (439..835): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YGASADLGNTVAKIILGGELNHYGPTETTVGVLT
Nearest Stachelhaus code(s):: Asp DLTKIGHVGK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS0210645: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (464..862): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFFCSGEYNLYGPTEAAIDVTA
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS0210655: His

Search NORINE for peptide: strict or relaxed

AMP-binding (444..837): His

nrpys: His

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: SARSFDSSVAGWLTIVAGEYNEYGPTEGTVWSSA
Nearest Stachelhaus code(s):: His DSALIAEVWK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS27605: Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (467..870): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: AGWAFDVFVGDREFICGSDINSYGLTETTIDSSY
Nearest Stachelhaus code(s):: Orn DVGEIGSIDK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS27610: Gln

Search NORINE for peptide: strict or relaxed

AMP-binding (495..893): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: HWMTFDASVWEAQLFCGGEYNLYGPTEATIDTTF
Nearest Stachelhaus code(s):: Gln DAWQFGLIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS0210670: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (453..850): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LATAFDAATFEGWLLAGGDINGYGPTENTTFSCC
Nearest Stachelhaus code(s):: Val DAFWLGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_ALVU02000001.1 - Region 5 - NRPS

Download region GenBank file

Download region SVG

Location: 3,666,325 - 3,718,032 nt. (total: 51,708 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase methyltransferase

SYN7509_RS0218465: methyltransferase

smcogs: SMCOG1089: methyltransferase

SYN7509_RS0218475: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: ligase

SYN7509_RS0218505: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SYN7509_RS0218510: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SYN7509_RS0218515: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

SYN7509_RS26390: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.74	NRPS	enniatin	Fusarium equiseti
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001133.4	0.68	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.74	NRPS	enniatin	Fusarium equiseti
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001133.4	0.68	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55

Confidence: medium

Additional weak hits (4):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.69 out of 29.38

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.16 out of 30.25

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 5, location 3666324 - 3718032:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile) + (NMe-Val) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SYN7509_RS0218505: X

AMP-binding (474..862): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VAQAFDASIFEMTLILAGEFNAYGLTETSIWSTI
Nearest Stachelhaus code(s):: Ph-Ser or Phe DAFTVAAIWK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)

SYN7509_RS0218510: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (530..916): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: VGQSFDASIFELIIIAGGEFNAYGLTETTIWATT
Nearest Stachelhaus code(s):: Leu DAWIIGAIVK (50% 8Å match)
Stachelhaus code match:: 80% (moderate)

SYN7509_RS0218515: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (494..887): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LSNAFDAATFEGFLLFGGELHVYGPTENTTFTTW
Nearest Stachelhaus code(s):: Ile DAFFLGVTFK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

SYN7509_RS26390: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (49..447): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFNIASLELQALCGGEWNMYGAPETTSWSTI
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (82% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_ALVU02000002.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 56,886 - 86,090 nt. (total: 29,205 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

SYN7509_RS0221490: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

SYN7509_RS0221525: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.58	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002110.3	0.52	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001229.4	0.51	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000516.4	0.50	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001576.3	0.49	ribosomal	divamide A	Prochloron didemni
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.58	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002110.3	0.52	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.52	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001229.4	0.51	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000516.4	0.50	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001576.3	0.49	ribosomal	divamide A	Prochloron didemni
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for SYN7509_RS0221490

SYN7509_RS31455

Leader:

MEEISAFSAHYNNIAALGNILFG

Core:

CVGTMFAAQNKYSTITP

Core with dehydrations:

CysVGDhbMFAAQNKYDhaDhbIDhbP

antiSMASH-DB 4.0 matches for SYN7509_RS31455

100.0%

NZ_ALVU02000002.1:

Lanthipeptides: SYN7509_RS31455_lanthipeptide

CVGTMFAAQNKYSTITP

SYN7509_RS27840

Leader:

MSHENIIRAWKDADFRNRLSEKERALLPKNPVGLVELTDAELGFAAGG

Core:

RYNNTGDGGCSQSPHCI

Core with dehydrations:

RYNNDhbGDGGCysDhaQDhaPHCysI

antiSMASH-DB 4.0 matches for SYN7509_RS27840

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS27840_lanthipeptide

Lanthipeptides: SYN7509_RS27840_lanthipeptide

RYNNTGDGGCSQSPHCI

41.2%

NZ_CP094681.1and 3 others:

NZ_JADNBM010000025.1 Lanthipeptides: allorf_12785_12913_lanthipeptideNZ_JAQDZW010000013.1 Lanthipeptides: allorf_048148_048276_lanthipeptideNZ_QVMC01000003.1 Lanthipeptides: allorf_247675_247803_lanthipeptide

Lanthipeptides: allorf_1123528_1123656_lanthipeptide

YNNTGDGG

YNNTG GG

YNNTGKGG

22.2%

NC_002570.2and 1 other:

NZ_CP040441.1 Lanthipeptides: allorf_0521154_0521291_lanthipeptide

Lanthipeptides: allorf_0482149_0482286_lanthipeptide

GDGGCSQSPHCI

GD CS P C+

GDTNCSARPSCL

SYN7509_RS26680

Leader:

MSHENIVRAWKDTEFCNSLSEKERLLLPENPVGLVQLTDAELGAVVGR

Core:

IAAVTDKTCPALRRYC

Core with dehydrations:

IAAVDhbDKDhbCysPALRRYCys

antiSMASH-DB 4.0 matches for SYN7509_RS26680

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS26680_lanthipeptide

Lanthipeptides: SYN7509_RS26680_lanthipeptide

IAAVTDKTCPALRRYC

21.9%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

AAVTDKTCP

A V+DKTCP

AYVSDKTCP

21.4%

NZ_KV802313.1and 1 other:

NZ_KV817389.1 Lanthipeptides: allorf_50141_50287_lanthipeptide

Lanthipeptides: allorf_165895_166041_lanthipeptide

TCPALRRYC

T PA RYC

TSPASERYC

with 4 more sequence matches

17.6%

NZ_JALANL010000003.1and 3 others:

NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptideNZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptideNZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide

Lanthipeptides: MOC63_RS03255_lanthipeptide

IAAVTDKTCPALRRYC

I + K CP+ +R C

ICKWSIKYCPSFKRKC

16.1%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

VTDKTCP

++DKTCP

ISDKTCP

15.4%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

TDKTCPAL

+DKTCP L

SDKTCPTL

14.7%

NZ_CP023481.1and 3 others:

NZ_FOHE01000009.1 Lanthipeptides: BMX40_RS20255_lanthipeptideNZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptideNZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide

Lanthipeptides: COP00_RS24795_lanthipeptide

KTCPALRRYC

K CP+ +R C

KYCPSFKRKC

SYN7509_RS26685

Leader:

MSHENIIRAWKDEEFRNSLSEKERALLPENPVGLVELTNNELGNVSGG

Core:

RRNDDTLGGSYDCTYICCVTVKRQDPL

Core with dehydrations:

RRNDDDhbLGGDhaYDCysDhbYICysCysVDhbVKRQDPL

antiSMASH-DB 4.0 matches for SYN7509_RS26685

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS26685_lanthipeptide

Lanthipeptides: SYN7509_RS26685_lanthipeptide

RRNDDTLGGSYDCTYICCVTVKRQDPL

25.9%

NZ_FONG01000023.1and 4 others:

NZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptideNZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptideNZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptideNZ_FONG01000023.1 Lanthipeptides: BM076_RS29665_lanthipeptide

Lanthipeptides: BM076_RS29665_lanthipeptide

LGGSYDCTYICCVTVKRQD

+GGS+ ++ CC T D

IGGSWQWSFSCCDTTLCSD

21.1%

NZ_KQ236748.1:

Lanthipeptides: HMPREF0980_RS19040_lanthipeptide

TLGGSYDCTYICC

TL S CT ICC

TLACSQFCTIICC

with 2 more sequence matches

15.4%

NZ_CP045142.1:

Lanthipeptides: allorf_1407493_1407663_lanthipeptide

TYICCVTVKRQDP

T + CV + R DP

TIVNCVVILRSDP

11.9%

NZ_KB903838.1:

Lanthipeptides: A3G1_RS0131055_lanthipeptide

SYDCTYICC

S+ CT+ CC

SFACTWPCC

MIBiG 4.0 matches for SYN7509_RS26685

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

RRNDDTLGGSYD

+RN++ YD

KRNEEVAESGYD

SYN7509_RS28800

Leader:

MSHENIIRAWKDENYRQSLTPEEQSLLPANPAGMLELTDTQLENAAGG

Core:

RKFTYGGDESCNSGIIACTLPLICGVEK

Core with dehydrations:

RKFDhbYGGDEDhaCysNDhaGIIACysDhbLPLICysGVEK

antiSMASH-DB 4.0 matches for SYN7509_RS28800

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS28800_lanthipeptide

Lanthipeptides: SYN7509_RS28800_lanthipeptide

RKFTYGGDESCNSGIIACTLPLICGVEK

30.0%

NZ_CYXV01000003.1:

Lanthipeptides: ARB75_RS04585_lanthipeptide

NSGIIACTLPLICGV

NSG IACTL C +

NSGGIACTLTGECNI

25.0%

NZ_JH992901.1and 1 other:

NZ_JH992901.1 Lanthipeptides: allorf_3864187_3864270_lanthipeptide

Lanthipeptides: allorf_3866459_3866542_lanthipeptide

IACTLPLICGVEK

+ CT LIC V K

VLCTQELICKVRK

with 5 more sequence matches

24.1%

NZ_JAGFVL010000062.1:

Lanthipeptides: J5J03_RS19425_lanthipeptide

TYGGDESCNSGIIACTLPLIC

++ GD +C++GI C+ C

SFTGDCTCDNGITVCSWSGCC

19.4%

NZ_FOMK01000014.1:

Lanthipeptides: allorf_183755_183922_lanthipeptide

GDESCNSGII

GD SCN+G +

GDASCNTGNV

18.2%

NZ_CP031598.1:

Lanthipeptides: allorf_1758445_1758579_lanthipeptide

DESCNSGIIA

++SCN+ IIA

NQSCNARIIA

17.3%

NZ_CZAY01000009.1and 12 others:

NZ_CZBA01000009.1 Lanthipeptides: ARA06_RS08755_lanthipeptideNZ_CZBB01000003.1 Lanthipeptides: ARA29_RS04330_lanthipeptideNZ_JADPDU010000003.1 Lanthipeptides: I4V06_RS02990_lanthipeptideNZ_JAOQJU010000001.1 Lanthipeptides: OCV99_RS00835_lanthipeptideNZ_JAQCSY010000025.1 Lanthipeptides: PGZ10_RS13865_lanthipeptideNZ_JAQEDC010000020.1 Lanthipeptides: PHA23_RS12680_lanthipeptideNZ_QRZZ01000001.1 Lanthipeptides: DWV87_RS01465_lanthipeptideNZ_QSUB01000001.1 Lanthipeptides: DXB81_RS03120_lanthipeptideNZ_QUCI01000019.1 Lanthipeptides: DW648_RS14740_lanthipeptideNZ_QULD01000003.1 Lanthipeptides: DXB83_RS07060_lanthipeptideNZ_QULI01000007.1 Lanthipeptides: DXB71_RS08970_lanthipeptideNZ_SLZV01000043.1 Lanthipeptides: EDD74_RS14380_lanthipeptide

Lanthipeptides: ARA07_RS06830_lanthipeptide

RKFTYGGDESCNSGIIACT

KF G E+ NSG + CT

NKFVAGAGETRNSGGVLCT

15.9%

NZ_CP031648.1and 2 others:

NZ_CP048607.1 Lanthipeptides: allorf_4200694_4200858_lanthipeptideNZ_CP048810.1 Lanthipeptides: allorf_5142037_5142201_lanthipeptide

Lanthipeptides: allorf_4581527_4581691_lanthipeptide

FTYGGDESCNSGIIACTLPL

+ G D C SG +PL

YALGRDAPCQSGTGGARMPL

MIBiG 4.0 matches for SYN7509_RS28800

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

GDESCNSGIIAC

DES AC

DDESSRPAAPAC

SYN7509_RS0221520

Leader:

MSNENIIRAWKDREFRNSLSKQESELLPTHPAGLVELIDEDLGAAAGGIRAEDTHYM

Core:

SKCIVCC

Core with dehydrations:

DhaKCysIVCysCys

antiSMASH-DB 4.0 matches for SYN7509_RS0221520

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS0221520_lanthipeptide

Lanthipeptides: SYN7509_RS0221520_lanthipeptide

SKCIVCC

allorf_079353_079487

Leader:

MIVLKGLEAG

Core:

VKNLSCEAKYQEAVKKARHFFLRLQEQLQWRPKR

Core with dehydrations:

VKNLDhaCysEAKYQEAVKKARHFFLRLQEQLQWRPKR

Lanthipeptide(s) for SYN7509_RS0221525

SYN7509_RS27840

Leader:

MSHENIIRAWKDADFRNRLSEKERALLPKNPVGLVELTDAELGFAAGG

Core:

RYNNTGDGGCSQSPHCI

Core with dehydrations:

RYNNDhbGDGGCysDhaQDhaPHCysI

antiSMASH-DB 4.0 matches for SYN7509_RS27840

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS27840_lanthipeptide

Lanthipeptides: SYN7509_RS27840_lanthipeptide

RYNNTGDGGCSQSPHCI

41.2%

NZ_CP094681.1and 3 others:

Lanthipeptides: allorf_1123528_1123656_lanthipeptide

YNNTGDGG

YNNTG GG

YNNTGKGG

22.2%

NC_002570.2and 1 other:

NZ_CP040441.1 Lanthipeptides: allorf_0521154_0521291_lanthipeptide

Lanthipeptides: allorf_0482149_0482286_lanthipeptide

GDGGCSQSPHCI

GD CS P C+

GDTNCSARPSCL

SYN7509_RS26680

Leader:

MSHENIVRAWKDTEFCNSLSEKERLLLPENPVGLVQLTDAELGAVVGR

Core:

IAAVTDKTCPALRRYC

Core with dehydrations:

IAAVDhbDKDhbCysPALRRYCys

antiSMASH-DB 4.0 matches for SYN7509_RS26680

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS26680_lanthipeptide

Lanthipeptides: SYN7509_RS26680_lanthipeptide

IAAVTDKTCPALRRYC

21.9%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

AAVTDKTCP

A V+DKTCP

AYVSDKTCP

21.4%

NZ_KV802313.1and 1 other:

NZ_KV817389.1 Lanthipeptides: allorf_50141_50287_lanthipeptide

Lanthipeptides: allorf_165895_166041_lanthipeptide

TCPALRRYC

T PA RYC

TSPASERYC

with 4 more sequence matches

17.6%

NZ_JALANL010000003.1and 3 others:

NZ_MUEI01000003.1 Lanthipeptides: BV582_RS23575_lanthipeptideNZ_NIJN01000002.1 Lanthipeptides: CHCC5027_RS22460_lanthipeptideNZ_NIMF01000037.1 Lanthipeptides: CHCC14814_RS22115_lanthipeptide

Lanthipeptides: MOC63_RS03255_lanthipeptide

IAAVTDKTCPALRRYC

I + K CP+ +R C

ICKWSIKYCPSFKRKC

16.1%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06520_lanthipeptide

VTDKTCP

++DKTCP

ISDKTCP

15.4%

NZ_NTWJ01000043.1and 1 other:

NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide

Lanthipeptides: CN427_RS31525_lanthipeptide

TDKTCPAL

+DKTCP L

SDKTCPTL

14.7%

NZ_CP023481.1and 3 others:

NZ_FOHE01000009.1 Lanthipeptides: BMX40_RS20255_lanthipeptideNZ_JALARN010000006.1 Lanthipeptides: MOE03_RS17410_lanthipeptideNZ_JAQCPU010000013.1 Lanthipeptides: PG077_RS20425_lanthipeptide

Lanthipeptides: COP00_RS24795_lanthipeptide

KTCPALRRYC

K CP+ +R C

KYCPSFKRKC

SYN7509_RS26685

Leader:

MSHENIIRAWKDEEFRNSLSEKERALLPENPVGLVELTNNELGNVSGG

Core:

RRNDDTLGGSYDCTYICCVTVKRQDPL

Core with dehydrations:

RRNDDDhbLGGDhaYDCysDhbYICysCysVDhbVKRQDPL

antiSMASH-DB 4.0 matches for SYN7509_RS26685

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS26685_lanthipeptide

Lanthipeptides: SYN7509_RS26685_lanthipeptide

RRNDDTLGGSYDCTYICCVTVKRQDPL

25.9%

NZ_FONG01000023.1and 4 others:

Lanthipeptides: BM076_RS29665_lanthipeptide

LGGSYDCTYICCVTVKRQD

+GGS+ ++ CC T D

IGGSWQWSFSCCDTTLCSD

21.1%

NZ_KQ236748.1:

Lanthipeptides: HMPREF0980_RS19040_lanthipeptide

TLGGSYDCTYICC

TL S CT ICC

TLACSQFCTIICC

with 2 more sequence matches

15.4%

NZ_CP045142.1:

Lanthipeptides: allorf_1407493_1407663_lanthipeptide

TYICCVTVKRQDP

T + CV + R DP

TIVNCVVILRSDP

11.9%

NZ_KB903838.1:

Lanthipeptides: A3G1_RS0131055_lanthipeptide

SYDCTYICC

S+ CT+ CC

SFACTWPCC

MIBiG 4.0 matches for SYN7509_RS26685

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

RRNDDTLGGSYD

+RN++ YD

KRNEEVAESGYD

SYN7509_RS28800

Leader:

MSHENIIRAWKDENYRQSLTPEEQSLLPANPAGMLELTDTQLENAAGG

Core:

RKFTYGGDESCNSGIIACTLPLICGVEK

Core with dehydrations:

RKFDhbYGGDEDhaCysNDhaGIIACysDhbLPLICysGVEK

antiSMASH-DB 4.0 matches for SYN7509_RS28800

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS28800_lanthipeptide

Lanthipeptides: SYN7509_RS28800_lanthipeptide

RKFTYGGDESCNSGIIACTLPLICGVEK

30.0%

NZ_CYXV01000003.1:

Lanthipeptides: ARB75_RS04585_lanthipeptide

NSGIIACTLPLICGV

NSG IACTL C +

NSGGIACTLTGECNI

25.0%

NZ_JH992901.1and 1 other:

NZ_JH992901.1 Lanthipeptides: allorf_3864187_3864270_lanthipeptide

Lanthipeptides: allorf_3866459_3866542_lanthipeptide

IACTLPLICGVEK

+ CT LIC V K

VLCTQELICKVRK

with 5 more sequence matches

24.1%

NZ_JAGFVL010000062.1:

Lanthipeptides: J5J03_RS19425_lanthipeptide

TYGGDESCNSGIIACTLPLIC

++ GD +C++GI C+ C

SFTGDCTCDNGITVCSWSGCC

19.4%

NZ_FOMK01000014.1:

Lanthipeptides: allorf_183755_183922_lanthipeptide

GDESCNSGII

GD SCN+G +

GDASCNTGNV

18.2%

NZ_CP031598.1:

Lanthipeptides: allorf_1758445_1758579_lanthipeptide

DESCNSGIIA

++SCN+ IIA

NQSCNARIIA

17.3%

NZ_CZAY01000009.1and 12 others:

Lanthipeptides: ARA07_RS06830_lanthipeptide

RKFTYGGDESCNSGIIACT

KF G E+ NSG + CT

NKFVAGAGETRNSGGVLCT

15.9%

NZ_CP031648.1and 2 others:

NZ_CP048607.1 Lanthipeptides: allorf_4200694_4200858_lanthipeptideNZ_CP048810.1 Lanthipeptides: allorf_5142037_5142201_lanthipeptide

Lanthipeptides: allorf_4581527_4581691_lanthipeptide

FTYGGDESCNSGIIACTLPL

+ G D C SG +PL

YALGRDAPCQSGTGGARMPL

MIBiG 4.0 matches for SYN7509_RS28800

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

GDESCNSGIIAC

DES AC

DDESSRPAAPAC

SYN7509_RS0221520

Leader:

MSNENIIRAWKDREFRNSLSKQESELLPTHPAGLVELIDEDLGAAAGGIRAEDTHYM

Core:

SKCIVCC

Core with dehydrations:

DhaKCysIVCysCys

antiSMASH-DB 4.0 matches for SYN7509_RS0221520

100.0%

NZ_ALVU02000002.1and 1 other:

NZ_ALVU02000002.1 Lanthipeptides: SYN7509_RS0221520_lanthipeptide

Lanthipeptides: SYN7509_RS0221520_lanthipeptide

SKCIVCC

allorf_079353_079487

Leader:

MIVLKGLEAG

Core:

VKNLSCEAKYQEAVKKARHFFLRLQEQLQWRPKR

Core with dehydrations:

VKNLDhaCysEAKYQEAVKKARHFFLRLQEQLQWRPKR

allorf_084117_084311

Leader:

MRTFQPMDVFWMSYFLILFWKKSFADKRREGDNAQPHFRYSRKSRAYA

Core:

KTSNILLSLDCSVLTF

Core with dehydrations:

KDhbDhaNILLDhaLDCysDhaVLDhbF

antiSMASH-DB 4.0 matches for allorf_084117_084311

100.0%

NZ_ALVU02000002.1:

Lanthipeptides: allorf_084117_084311_lanthipeptide

KTSNILLSLDCSVLTF

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.64 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.76 out of 29.25

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.33 out of 29.72

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.25 out of 32.93

Confidence: medium

Additional weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.19 out of 29.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 23.18 out of 32.38

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

SYN7509_RS31455 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 1758.9 Da

Molecular weight: 1760.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1778.0 Da N = 1; 1796.1 Da N = 2; 1814.1 Da N = 3

SYN7509_RS27840 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 1753.7 Da

Molecular weight: 1754.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1772.9 Da N = 1

SYN7509_RS26680 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 1743.9 Da

Molecular weight: 1745.1 Da

Number of bridges: 2

SYN7509_RS26685 - Class II

Cleavage pHMM score: 1.20

RODEO score: 0

Monoisotopic mass: 3018.4 Da

Molecular weight: 3020.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3038.4 Da N = 1

SYN7509_RS28800 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 2901.4 Da

Molecular weight: 2903.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2921.4 Da N = 1

SYN7509_RS0221520 - Class II

Cleavage pHMM score: -2.80

RODEO score: 0

Monoisotopic mass: 736.3 Da

Molecular weight: 737.0 Da

Number of bridges: 1

allorf_079353_079487 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 4209.3 Da

Molecular weight: 4211.9 Da

Number of bridges: 1

SYN7509_RS27840 - Class II

Cleavage pHMM score: -3.40

RODEO score: 0

Monoisotopic mass: 1753.7 Da

Molecular weight: 1754.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1772.9 Da N = 1

SYN7509_RS26680 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 1743.9 Da

Molecular weight: 1745.1 Da

Number of bridges: 2

SYN7509_RS26685 - Class II

Cleavage pHMM score: 1.20

RODEO score: 0

Monoisotopic mass: 3018.4 Da

Molecular weight: 3020.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3038.4 Da N = 1

SYN7509_RS28800 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 2901.4 Da

Molecular weight: 2903.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2921.4 Da N = 1

SYN7509_RS0221520 - Class II

Cleavage pHMM score: -2.80

RODEO score: 0

Monoisotopic mass: 736.3 Da

Molecular weight: 737.0 Da

Number of bridges: 1

allorf_079353_079487 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 4209.3 Da

Molecular weight: 4211.9 Da

Number of bridges: 1

allorf_084117_084311 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 1662.9 Da

Molecular weight: 1664.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1682.0 Da N = 1; 1700.0 Da N = 2; 1718.0 Da N = 3; 1736.0 Da N = 4

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response
MexT	Global virulence regulator
NtrC	Nitrogen regulatory protein C
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor