LOCUS       NC_019673              21128 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Saccharothrix espanaensis DSM 44229, complete sequence.
ACCESSION   NC_019673
VERSION     NC_019673.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Saccharothrix espanaensis DSM 44229
  ORGANISM  Saccharothrix espanaensis DSM 44229
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Saccharothrix.
REFERENCE   1
  AUTHORS   Strobel,T., Al-Dilaimi,A., Blom,J., Gessner,A., Kalinowski,J.,
            Luzhetska,M., Puhler,A., Szczepanowski,R., Bechthold,A. and
            Ruckert,C.
  TITLE     Complete genome sequence of Saccharothrix espanaensis DSM 44229(T)
            and comparison to the other completely sequenced Pseudonocardiaceae
  JOURNAL   BMC Genomics 13, 465 (2012)
   PUBMED   22958348
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9360653)
  AUTHORS   Rueckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2012) IGS, CeBiTec, Bielefeld University,
            Universitaetsstr. 27, D-33335, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000328705.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:06:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,451
            Genes (coding)                    :: 8,313
            CDSs (with protein)               :: 8,313
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 43 of 138
            Pseudo Genes (incomplete)         :: 116 of 138
            Pseudo Genes (internal stop)      :: 7 of 138
            Pseudo Genes (multiple problems)  :: 27 of 138
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:45:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5878505
            Orig. end                         :: 5899633
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE804045.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="25"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11128](-)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11128)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            780..1853
                     /locus_tag="BN6_RS25400"
                     /old_locus_tag="BN6_52550"
     CDS             780..1853
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS25400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_52550"
                     /product="hypothetical protein"
                     /protein_id="WP_015102631.1"
                     /transl_table=11
                     /translation="MGSDALAELTFTVLAAKNALKSSRDHLHDIVESRLVNDPDTAAFW
                     AGYAAGGQVSPELTAALAGKLRQDERFAARVEGLVNRAMWRRRLVPRRDVLLGIGLAVA
                     GGVTGAVSAPFGEPRAQDHVKQAEEEKARSKGVLAAKVERQVRVDDALGWVFADPLSDA
                     QVRDLPATKGRPVPGPLVGVARPVYIPLNSFGKLYNFTRARVTVVNHWPKPVLITDVRA
                     KVKRTAPLSGALVWAGAQGGVPVIDLTFDLEEDEPRARTVDADGTLGDPWTYSENVELE
                     PGQTQPFNVDGRATASCCEWYLEIHAEIGGEKQVFEAREAAGPFTTTAFADHYRQRFSY
                     QVNGGTWIERGEGGMFR"
     misc_feature    799..813
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            1850..2665
                     /locus_tag="BN6_RS25405"
                     /old_locus_tag="BN6_52560"
     CDS             1850..2665
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS25405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_52560"
                     /product="hypothetical protein"
                     /protein_id="WP_015102632.1"
                     /transl_table=11
                     /translation="MRTGVRRTLIVVVCFAAGFLVSRAVRWETEPATTPPTPWSTVPAQ
                     EPRIDARVAPGALDDGAGWVLMAAEDLARAEPPDDVVDCGGLRDWALREGAVPAGNAPH
                     SIEVTANYRTTVQTVHVRVLPDPTPYSGKPPTVRLACLPRPDAVLPFPEPDAARVKVNG
                     EPSLLDPVQKQTTLYRPHEVRPRSPAELEVVVDLTGSTGPFAYRVEIDVVEQNEFRGRA
                     ASGPLFATEDGGGMGYWPATATWTMSPSRTHVYCEPVTNPTPGTEPTCT"
     gene            complement(2760..3887)
                     /locus_tag="BN6_RS25410"
                     /old_locus_tag="BN6_52570"
     CDS             complement(2760..3887)
                     /codon_start=1
                     /function="Fucose permease"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="BN6_RS25410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52570"
                     /product="sugar MFS transporter"
                     /protein_id="WP_015102633.1"
                     /transl_table=11
                     /translation="MSSEPTRTATAAAFAFFVLLGGVTAALGAALPVLRAEYGLAAGEG
                     GSLIACYSFGGFTAIALCGLFAHRLPGPLVLRLSVVLFAAGCVGMGLADTWPVLVTAGA
                     VTGLGYGGAVLHLNVAFAQRFDGVLMLNFLNAAFGAGTITGPLAVGWMPTITPAFPVIG
                     VLALLCLPAGQAAPRHAPPPPSRHHLPAGLLAPFTLMVLLYAGLETGVGAWQATHLISQ
                     GLPPDTAVHWVSAFWAALALGRIVIPLVTRTQPLHRVVVYCLAAATAALAVATIPPLTP
                     YAYTAAGLCLAPVIPVAVAWLTGRTPAAPQATAFLFAASMAGSTTLPLLVGILATPPTP
                     ALPIPLALTTIGAAALAAALATAHRHASPTPGFRR"
     misc_feature    complement(3678..3680)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3877..5028)
                     /gene="eis"
                     /locus_tag="BN6_RS25415"
                     /old_locus_tag="BN6_52580"
     CDS             complement(3877..5028)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /function="Predicted acetyltransferase involved in
                     intracellular survival and related acetyltransferases"
                     /gene="eis"
                     /inference="COORDINATES: protein motif:HMM:NF024917.5"
                     /locus_tag="BN6_RS25415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52580"
                     /product="enhanced intracellular survival protein Eis"
                     /protein_id="WP_015102634.1"
                     /transl_table=11
                     /translation="MTSEPIVTAPRHQRDWDQYSRLAAESFGGDHRDLTCHRSRGPAAV
                     AVVDDEVIGGAVALRAHQFFGGSAVPTGCVADVCVRPEWRGRGVARRVIDTLMDRTRAD
                     GGVLSTLWTPATGVYRRWGWEVAGLGRRWSVPARGLRSLPAAPGDVVPGFTEPARELQR
                     DLARAWDGPLRRPSWWWDWKYSDSEHRCYTLVVGGEPQGLLGVRVRPVEPWGQDLVVSD
                     FWARDTASGRALLRFLGGFGSMAHTVHFDTGTLANLPALVWELPQHELREQGWYPWMLR
                     LLDIPAALESRGWPRTVTGRLDLAITGPAAQRLVLEVADGRAVTSPGGTGAVALSPGQL
                     AAWYAGTLDPPALTRSLGPLDDGIVELMGMLTRRTEVWLPDVF"
     gene            complement(5387..6037)
                     /locus_tag="BN6_RS25420"
                     /old_locus_tag="BN6_52590"
     CDS             complement(5387..6037)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /function="Predicted phosphatase/phosphohexomutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102635.1"
                     /locus_tag="BN6_RS25420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52590"
                     /product="HAD-IA family hydrolase"
                     /protein_id="WP_015102635.1"
                     /sec_met_domain="HAD_2 (E-value: 9.6e-22, bitscore: 76.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLVADVILFDLDGVLVDSSGCVAKAWFEWAARHGLDAERTFAL
                     GHGRTTADHLRAAAPDLATPEEAAAVDALEERYVTEVVAQPGAREATAELTRLGRRWGI
                     VTSCDHPAATARLAVAGIPAPDVLVTAADVEQHKPAPDGYLLGCRRTGVEPAGALVFED
                     APAGLAAARAAGIRAVALSTTHDPAELTGSDAIVPDLAHVRFGPRGEVALRTG"
     gene            complement(6034..6687)
                     /locus_tag="BN6_RS25425"
                     /old_locus_tag="BN6_52600"
     CDS             complement(6034..6687)
                     /GO_function="GO:0004750 - D-ribulose-phosphate 3-epimerase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016857 - racemase and epimerase activity,
                     acting on carbohydrates and derivatives [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence
                     IEA]"
                     /codon_start=1
                     /function="Pentose-5-phosphate-3-epimerase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102636.1"
                     /locus_tag="BN6_RS25425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52600"
                     /product="ribulose-phosphate 3-epimerase"
                     /protein_id="WP_015102636.1"
                     /transl_table=11
                     /translation="MVMIAPALLGADPLALADAIADVERAEADLLHVDVMDGHFVRDIN
                     FGLRTVRAIRERTTLPVDVHLQVQQPERLLDELVDIAPDTVSVHVESTQHLSAVLRGLE
                     GGGIRKGVVLNPATPLGVLDEVLEQVDQVVLMTSNPGTSDFLPHVLDKIGRLRALLVKR
                     GIEHVRLVADGGVTAERAGRLVDAGADVLVAASAVFAPRHGGPPAAVGTLRAAR"
     gene            complement(6713..7831)
                     /locus_tag="BN6_RS25430"
                     /old_locus_tag="BN6_52610"
     CDS             complement(6713..7831)
                     /NRPS_PKS="Domain: Aminotran_5 (36-164). E-value: 8.4e-11.
                     Score: 33.3. Matches aSDomain:
                     nrpspksdomains_BN6_RS25430_Aminotran_5.1"
                     /codon_start=1
                     /function="Predicted pyridoxal phosphate-dependent enzyme
                     apparently involved in regulation of cell wall biogenesis"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102637.1"
                     /locus_tag="BN6_RS25430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52610"
                     /product="DegT/DnrJ/EryC1/StrS aminotransferase family
                     protein"
                     /protein_id="WP_015102637.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.4e-115,
                     bitscore: 384.6, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.6e-07, bitscore:
                     29.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVTKYHHRAQFADLDALTARIRDALAAGDYILGPAVERFEERFA
                     AHTGVAHAVGLNSGTDALVLALRALDVGPGDEVITVANTFHASVLAITAVGARPVLVDC
                     TPGDHLMDLDQVDAAVTPRTRAVLAVHLFGQALDMDRLGAIADRHGLAVVEDCAQAVGA
                     RWAGRRVGGFGRVGCFSFHPSKNLAAAGDGGAITTDDPEIARRVKVLRGLGQRAQNDHV
                     VRGCNSKLDVIQALVLDDKLDRLDGWNARRAEVAGHYARALAGTGVAATPPAGQRHVFH
                     LYQVAVDRRDEVFEEMTARGVEVVVRYPVPVHRQPAFADLGLTGSFPNAEAQARGTLCL
                     PVRPDLTGPEIDYVLDVLLAATGHRPRRLVAG"
     aSDomain        complement(7340..7723)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS25430_Aminotran_5.1"
                     /evalue="8.40E-11"
                     /label="BN6_RS25430_Aminotran_5.1"
                     /locus_tag="BN6_RS25430"
                     /protein_end="164"
                     /protein_start="36"
                     /score="33.3"
                     /tool="antismash"
                     /translation="VERFEERFAAHTGVAHAVGLNSGTDALVLALRALDVGPGDEVITV
                     ANTFHASVLAITAVGARPVLVDCTPGDHLMDLDQVDAAVTPRTRAVLAVHLFGQALDMD
                     RLGAIADRHGLAVVEDCAQAVGAR"
     gene            complement(7828..8874)
                     /locus_tag="BN6_RS25435"
                     /old_locus_tag="BN6_52620"
     CDS             complement(7828..8874)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /function="NADPH:quinone reductase and related Zn-dependent
                     oxidoreductases"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS25435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_52620"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_015102638.1"
                     /transl_table=11
                     /translation="MIPTGTPYRRLDHDDGRVVLGEARVAEPSGTSAKAVIAPRRVGVC
                     RSDLRELRSDRHLRRDFGHEIVAEVVGGTDGLGLVAGQRVVFDPHPPLHARTSGYGELV
                     ELEGAPEAVRGALVPVPDTVPEDRAVFAEPLACACHCVRRLEDAGGDRRSAVAVVGAGM
                     AGTLIAAVLHADGVPVSLVNRGAARLDFLRAHHVLPEDVLAPAAGRRFDRVVLATASAS
                     PEALDAALAMVRPGGVLLLFAGTRPGVELAGVDLDDLRRRERVERSSVAGVPLVLAGTH
                     GALRADFDRALGLLAATGPGWTAGAAVERLTTRRMSLAEAASALPDHAENGFVGKPVVV
                     LPHRGATP"
     gene            complement(8871..10004)
                     /locus_tag="BN6_RS25440"
                     /old_locus_tag="BN6_52630"
     CDS             complement(8871..10004)
                     /codon_start=1
                     /function="Threonine dehydrogenase and related Zn-dependent
                     dehydrogenases"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS25440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_52630"
                     /product="Cyclitol dehydrogenase"
                     /protein_id="WP_015102639.1"
                     /transl_table=11
                     /translation="MTGTAETTGATVATGVNLALVRRGTGSVVESRPAPAVRAGQRAAR
                     VLRAGVCGTDLQIQRRVRPDAATVLGHEALVELADPVTGVPWHAVLNPVDATDQDRVLG
                     HSYDGVFQQRLVVDEHGPELVAAGPGLVADLAPLVEPLATVLYGWELFEREPARVAVWG
                     GGSTAVLAAVVGELRGVRTFLLHPREERLRFLAGRGMFGTTSLHTGPPGVPVDAAFLCL
                     PREAAPAALTEAVAALGPDGVVDLVGGFGPGDRHPAAPGVDLGEVRRANACGLPRPGVV
                     VRRGAAGFTGHRGTARRHLERAQRLLLDHPESFGPVVTHVVSLEAAADELPALAARRAP
                     SAGPAERIKVLVDPTMTGRAHRAPDLFTTVGELGGTA"
     gene            complement(10001..11128)
                     /locus_tag="BN6_RS25445"
                     /old_locus_tag="BN6_52640"
     CDS             complement(10001..11128)
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /function="3-dehydroquinate synthetase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102640.1"
                     /locus_tag="BN6_RS25445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52640"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_015102640.1"
                     /sec_met_domain="salQ (E-value: 7.8e-155, bitscore: 514.2,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Fe-ADH (E-value: 4.3e-09, bitscore: 34.6,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 4.5e-67, bitscore:
                     224.9, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSWTVNATQEVSYDVRQTDRVLDPGNRDLARAAALHPGARRLVV
                     VDRQVWQLYGPDVRAYFRHQRVDARYVALPTDEPNKTVESVYAVVDAADAAGLNRRSDP
                     IIAIGGGVLTDVVGLAASLYRRGIPFIRVPTTLIGLVDAAVGVKTAINHHSHKNRLGTY
                     FPAATTLLDQSFLRTLPTRHVANGLAEIVKIALVRDRVLFDLLADRAADVVELVKHGGV
                     GGEIIERAVGGMLAELAPNLWEQELRRLVDFGHTFSPGFELNADHPLLHGEAVAVDMVL
                     CCLIAQGRGLLSEDEVRRVVRLLRLIGLPVTTSGVTPDQLVRCLEDATRHRDGHQHLPL
                     PQGLGHGVFVEDVTPEEIHRAHRSWVALDRLREVA"
     gene            complement(11109..12182)
                     /locus_tag="BN6_RS25450"
                     /old_locus_tag="BN6_52650"
     CDS             complement(11109..12182)
                     /codon_start=1
                     /function="Transcriptional regulator/sugar kinase"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.5"
                     /locus_tag="BN6_RS25450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52650"
                     /product="ROK family protein"
                     /protein_id="WP_015102641.1"
                     /transl_table=11
                     /translation="MSTVALGPRHPVLAFDLGGSWWRVGLLTDACAVRLLCRVPAVNHR
                     NTAKPVPGLQADLVDFVVERTREQRRRHGFDAVGVSLGAALNGHTGEVLGSAPLWGGGT
                     APFNLAAALREALPDVRWTVLNDVSALAVELLAHSLPGRRATAVTVSSGIACRTIDLRT
                     GHIPLDPVHGVQGEIGHLPARFTALGREVRAHCECGAPDHLAAFSSGRGIEALLRELPE
                     ARPLRDRSPDDVVGAFTAAVRGGDPRARSLLDDFTRPLAEVLLHQAVLDPGVERTVLSG
                     GVVDGLGDHYRDSLLRNLAALGLYGIDDPAYFARRITRASDDGLAALRGAGIRARSPLD
                     LIDVHLTKGERREVLDR"
     misc_feature    complement(12165..12167)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12179..12841)
                     /locus_tag="BN6_RS25455"
                     /old_locus_tag="BN6_52660"
     CDS             complement(12179..12841)
                     /EC_number="3.1.1.31"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013356.5"
                     /locus_tag="BN6_RS25455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52660"
                     /product="6-phosphogluconolactonase"
                     /protein_id="WP_051075733.1"
                     /transl_table=11
                     /translation="MATAVADLITRRVSDVLRERGTCLLALSGGSTPARAYRLLAGAGV
                     DWDAVHVVQTDERVTDDRPATSAAVIEDNLITPAGVSPSRWHPMPTAAHDLLGAVDRYA
                     ALLAGLTPGGVPDIALLGLGEDGHTASLFAGDPAVDDPAPVVVTQPYQGTVRVSMAVHL
                     LASVPTRVVLAAGAAKARAVARLRGGEVPDTDPAARVLGVDGELFADQAAAGEERAG"
     gene            13159..14364
                     /locus_tag="BN6_RS25460"
                     /old_locus_tag="BN6_52670"
     CDS             13159..14364
                     /codon_start=1
                     /function="Transcriptional regulator/sugar kinase"
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.5"
                     /locus_tag="BN6_RS25460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52670"
                     /product="ROK family protein"
                     /protein_id="WP_015102643.1"
                     /transl_table=11
                     /translation="MCRWPQFEVAGLPLTARVLNLVHERGRVARAEVTSTLGAARGATG
                     DAIAELVGLGLVRVCEPVRAGTRGRPSPTLAAEPGGPVAIAAQVTPIGLDLAVVGLHAE
                     IVARHRLALPDHIDDPARVIGALARAVTRLAEESGRACVGVGVGVAGMVRDEDGLVRSA
                     IHLGWRDVPAGDLLAAAVPAGLPVVVRRDAALVAMAEHRHGAGRDAGTLLVVTGHHWGV
                     GGALLGGGVSPHGTHLEVGHLVLDPRGRRCACGQRGCLETYTDGNALLRAAGLPESADS
                     AASERLLDSARAGEPAALAAAEEVARRLGIGLTSLVNIINPDRVVCTGTFAALLALARD
                     DVLHPSRRSVVATLDNPHTTPGAVEDPVLVGAAESVFLPLLRDPRTPLFRTDRPGGGVP
                     AP"
     gene            14361..14999
                     /locus_tag="BN6_RS25465"
                     /old_locus_tag="BN6_52680"
     CDS             14361..14999
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /function="ADP-ribose pyrophosphatase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102644.1"
                     /locus_tag="BN6_RS25465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52680"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_015102644.1"
                     /transl_table=11
                     /translation="MTAPDPAEVVHRHALRLLATAQNGLTYADDPYDRERYQEVRRAAE
                     GLLALVATGDLREVRRIVALDTGHATPKVDVRGAVFDPGGRVLLVRERSDGRWTLPGGW
                     CDVLESPAEAVAREVREESGLTVRVAKLVAVLDRERQGHRPRFPYHVHKLFFLCDEESR
                     GEPDPTEISAVDWFALDALPELSTSRVLEPQLHLAHTHWHDRTLPTVFD"
     gene            15124..15531
                     /locus_tag="BN6_RS25470"
                     /old_locus_tag="BN6_52690"
     CDS             15124..15531
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS25470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_52690"
                     /product="hypothetical protein"
                     /protein_id="WP_148303008.1"
                     /transl_table=11
                     /translation="MDDDRPAEEPPRRPTAGRRVINGLVVAGLAMVGWTLLRADLLPSP
                     GWLSRWWPAVASLLLFGVAFAVWRKGRVPRAAEPAVRRDWTQVITAATALGALVFTALS
                     LRAAQEQIEVAEQGQITDRYAKAVQLLGPRR"
     gene            complement(15850..16719)
                     /locus_tag="BN6_RS25475"
                     /old_locus_tag="BN6_52710"
     CDS             complement(15850..16719)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /function="Transcriptional regulator"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102647.1"
                     /locus_tag="BN6_RS25475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52710"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_015102647.1"
                     /transl_table=11
                     /translation="MPEPEIRELRYFRAVAEHLNITRAAERLGIAQPPLSRAMRQLERR
                     LGVDLFDRTGHRLALTRAGEILFEEAAAVLGALDAAVRRTRQAGLPFRGLVVTAKPGVA
                     TRLLLRVRERFRADPDAPEIRVVVSGFGEQADMVRDGRADLAIAACVDGHGLDTELVAT
                     EPRVAALAVGHELAGREVLSTADLLAEPAPRWSAPGVVDRDYWLGNPDRPADGPVVRDS
                     AQLLDVVALGQAVALVPSSLAALNVRPDVTYRPVPDATPYRTLVLWPAGSRSPWIARFV
                     QAALEGVS"
     misc_feature    16785..16796
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            16789..17583
                     /locus_tag="BN6_RS25480"
                     /old_locus_tag="BN6_52720"
     CDS             16789..17583
                     /NRPS_PKS="Domain: PKS_KR (5-190). E-value: 1.7e-09. Score:
                     29.8. Matches aSDomain:
                     nrpspksdomains_BN6_RS25480_PKS_KR.1"
                     /codon_start=1
                     /function="Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102648.1"
                     /locus_tag="BN6_RS25480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52720"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_015102648.1"
                     /transl_table=11
                     /translation="MNANEVALVTGGNKGIGREVVRRLAGQGFTVYLGARDPERGHCAV
                     EELTSAPDGAARTAKSGGRGNGLDIRFVRLDVGDVASVRAAVTTIEAATGRLDVLVNNA
                     GIMVEWDVRTTDITAAHLREVFEVNVFGVVTVTSACLPLLRRSPNPRVVNMSSGLGSLT
                     LLSDPESPLPAQGFLAYSSSKAALNAVTLIYANALRADGIKVNAASPGLVPTDQNAAAT
                     FPRGDRSTADGAVVPVLLSTISADGPTGVFRGPNSLDDVIPW"
     aSDomain        16804..17358
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS25480_PKS_KR.1"
                     /evalue="1.70E-09"
                     /label="BN6_RS25480_PKS_KR.1"
                     /locus_tag="BN6_RS25480"
                     /protein_end="190"
                     /protein_start="5"
                     /score="29.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGGNKGIGREVVRRLAGQGFTVYLGARDPERGHCAVEELTS
                     APDGAARTAKSGGRGNGLDIRFVRLDVGDVASVRAAVTTIEAATGRLDVLVNNAGIMVE
                     WDVRTTDITAAHLREVFEVNVFGVVTVTSACLPLLRRSPNPRVVNMSSGLGSLTLLSDP
                     ESPLPAQGFLAYSSSKAALNAV"
     CDS_motif       16810..16872
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS25480_0001"
                     /evalue="8.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN6_RS25480"
                     /protein_end="28"
                     /protein_start="7"
                     /score="18.5"
                     /tool="antismash"
                     /translation="LVTGGNKGIGREVVRRLAGQG"
     gene            complement(17661..18575)
                     /locus_tag="BN6_RS25485"
                     /old_locus_tag="BN6_52730"
     CDS             complement(17661..18575)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /function="Transcriptional regulator"
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102649.1"
                     /locus_tag="BN6_RS25485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52730"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_015102649.1"
                     /transl_table=11
                     /translation="MLTVSLAGLRAIEALAVHGSMTAAASALGYTPSAISQQIARLSRD
                     VHQQLVEHQAGRTTLTPAGRVLAESASRIVVELESMSAELQAQSDTVTGTLTVAAFPTA
                     TRGVLPGATEELTRAWPDLSLRLIEADSHRAVELVARGTADLAVAHDWMAIPLTLPEGL
                     QARHLGDDLSDVLAHHTHPLVGRASVDLDELRGDRWLYEPGSVAHDFLLNAFQHTPNPT
                     RFTHIVTEYASQIGLVGVGLGLALVPRMGRGPLPPSVRVLPVTAPPLRRIYGVWRTPTG
                     RRPALTAALAVLETVCARLEQDT"
     gene            complement(18650..19015)
                     /locus_tag="BN6_RS25490"
                     /old_locus_tag="BN6_52740"
     CDS             complement(18650..19015)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /function="Putative translation initiation inhibitor, yjgF
                     family"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102650.1"
                     /locus_tag="BN6_RS25490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52740"
                     /product="RidA family protein"
                     /protein_id="WP_015102650.1"
                     /transl_table=11
                     /translation="MIPPAGHYRPFVRAGDTVYVSGQVPRLPDGSYRPADVATETALAL
                     RNLAAVVAAAGGDRTCVVKVTAYLADVADFAEFDHAYAAHFGDWKPARTTVVAGLRSVK
                     VEVDAVLHLPATGGDGE"
     gene            complement(19012..19752)
                     /locus_tag="BN6_RS25495"
                     /old_locus_tag="BN6_52750"
     CDS             complement(19012..19752)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-174). E-value: 4.4e-15. Score:
                     48.0. Matches aSDomain:
                     nrpspksdomains_BN6_RS25495_PKS_KR.1"
                     /codon_start=1
                     /function="Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102651.1"
                     /locus_tag="BN6_RS25495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52750"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_015102651.1"
                     /sec_met_domain="adh_short (E-value: 3.1e-30, bitscore:
                     104.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAVDGKVAFLTGAAEGLGREIARELVTAGMRVALMDVQGGKLAA
                     LTEELRAAGADVLPLVVDLADPAATRDATETALAHYGPPRALIHNAAVLKEVSMLDVTF
                     EDWRREVDIILGAAYVLTKTVWPHLVAARDGSIVFLSSGSALSGFVKETAYTPGKHAQE
                     GLMKVLALEGREHNVAVNTMSTGRPIDTPMSDSHYTDEMRIGIVPPARLAPAFAFLAGI
                     DADFATGQRFNAFQVSSAILAARR"
     aSDomain        complement(19231..19731)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS25495_PKS_KR.1"
                     /evalue="4.40E-15"
                     /label="BN6_RS25495_PKS_KR.1"
                     /locus_tag="BN6_RS25495"
                     /protein_end="174"
                     /protein_start="7"
                     /score="48.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAFLTGAAEGLGREIARELVTAGMRVALMDVQGGKLAALTEELRA
                     AGADVLPLVVDLADPAATRDATETALAHYGPPRALIHNAAVLKEVSMLDVTFEDWRREV
                     DIILGAAYVLTKTVWPHLVAARDGSIVFLSSGSALSGFVKETAYTPGKHAQEGLMKVLA
                     LEGR"
     CDS_motif       complement(19657..19722)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS25495_0001"
                     /evalue="1.00E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN6_RS25495"
                     /protein_end="32"
                     /protein_start="10"
                     /score="14.9"
                     /tool="antismash"
                     /translation="LTGAAEGLGREIARELVTAGMR"
     gene            complement(19749..20486)
                     /locus_tag="BN6_RS25500"
                     /old_locus_tag="BN6_52760"
     CDS             complement(19749..20486)
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (9-168). E-value: 7.4e-09. Score:
                     27.7. Matches aSDomain:
                     nrpspksdomains_BN6_RS25500_PKS_KR.1"
                     /codon_start=1
                     /function="Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102652.1"
                     /locus_tag="BN6_RS25500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_52760"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_015102652.1"
                     /transl_table=11
                     /translation="MTHPTGRFALVAGNAEDLGHAVARELAAAGMTVAVLCDQADAVRA
                     LADELPSVHAFTTDFTDPHVLRARAEEVLERFGTPRLLVHNSAVFRETPVLELDGAAFA
                     AEVDSILQSAFVLSKAVWPGMVAARDGSIVFVSSGSALSGFANEAAYVAGKHGQEGLMK
                     VLALEGKDHNVAVNTITLGAPVDGPLAYTYTDAQRAVMVPPSRLAPAFAFLAGIDADFA
                     SGHRFNAFQLSEAIRVTAAGASS"
     aSDomain        complement(19983..20459)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS25500_PKS_KR.1"
                     /evalue="7.40E-09"
                     /label="BN6_RS25500_PKS_KR.1"
                     /locus_tag="BN6_RS25500"
                     /protein_end="168"
                     /protein_start="9"
                     /score="27.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVAGNAEDLGHAVARELAAAGMTVAVLCDQADAVRALADELPSVH
                     AFTTDFTDPHVLRARAEEVLERFGTPRLLVHNSAVFRETPVLELDGAAFAAEVDSILQS
                     AFVLSKAVWPGMVAARDGSIVFVSSGSALSGFANEAAYVAGKHGQEGLMKVLALE"
ORIGIN
        1 ggcgagcgca ccgccgcgtc caccagggcg cgctggacgg tgggcgcgtg accgcacgcg
       61 tcgtcgtgga cgtgccgctc gccggcgatc agctgggcga cgacccggtt tccgaccgag
      121 cgctgcaacg ccgcaaccgc tgccggggtc agcggaccgg ggcggacggg gccccctcgc
      181 tcgtcggacc cgggaaacgg ccggcgcctg gcgctgggct ggtcgtccgg ccgcttctcc
      241 tgttcgcgca cgcgcacctg ccccctcggt cccgacttcg gtggacccct cccatcctgc
      301 acaccgggtg cggtacggcg aaccgtcggc cggtcccccg tcggggcact gttggtgtca
      361 gaacgggcaa cgcgggcacg gtgctcggcg tcagcgctcg taggcgacag cttgtccgga
      421 ggcggcccca tggtctgccc cacgacgccc gacaacttcg gatgtgcgga tcaggcggcc
      481 tgctccacct gttcgcctcc attgccgacc cgcgtgatct tcccgagcat gatccgggca
      541 caacccggtg gacgggcggt ggtggagtcc gccagtcggg cagtggtgtc cggcacgtgg
      601 aggtggaacg gcgatgtggg aaagcgcgct agcgcagacc ggcaccgact gtttgcagcg
      661 gtcggttcct tgtcgggcgg tcgatccgga tggccaggat cggtcatcgt tcagcccttt
      721 ccgcgcttgt gcgggttgct agcgtgcacg gcgccggtcc agcggtgtcg gggaggatca
      781 tggggtcaga cgcgttggcg gaactcacgt tcaccgtgct cgccgcgaag aacgcgctca
      841 agtcgagccg tgaccacctg cacgacatcg tggaatcgcg gctcgtgaac gacccggaca
      901 ccgccgcgtt ctgggcgggc tatgccgccg gtgggcaggt gtccccggaa ctgacggctg
      961 ccctggcggg aaagctgcgt caggacgagc ggttcgccgc gcgggtcgag ggcctggtga
     1021 accgcgcgat gtggcgtcgt cggctggttc cgagacgaga cgtgctgctc gggatcgggc
     1081 tcgcggtagc cgggggtgtc accggcgcgg tctccgcgcc gttcggtgaa ccccgggcgc
     1141 aggaccacgt caagcaggcg gaagaggaga aggcccggtc caagggtgtg ctcgcggcga
     1201 aggtggaacg ccaggtccgg gtggacgacg cattgggctg ggtgttcgcc gacccgttgt
     1261 cggacgccca ggtgcgcgac ctgccggcga ccaagggccg gcctgtgccg gggccgttgg
     1321 tcggtgtcgc acggccggtc tacatcccgc tcaactcctt cgggaagctc tacaacttca
     1381 ccagggcgag ggtgacggtc gtcaaccact ggccgaagcc ggtgctgatc accgatgtca
     1441 gggccaaggt gaagcggacg gcaccgctgt ccggcgcgct ggtgtgggcg ggcgcgcagg
     1501 gcggtgtccc ggtgatcgac ctgactttcg acctggagga ggacgagccg cgagcacgga
     1561 ccgtcgacgc ggacggcacg ctcggcgatc cctggaccta cagcgagaac gtggagctgg
     1621 aacccggtca gacccaaccg ttcaacgtcg acgggcgggc cacggcgtcg tgctgcgagt
     1681 ggtacctgga gatccacgcg gagatcggtg gggagaagca ggtcttcgag gcgagggagg
     1741 cggccgggcc cttcacgacc acggcgttcg ccgaccacta ccggcagcgc ttcagctacc
     1801 aggtcaacgg cggcacgtgg atcgagcgcg gcgagggcgg gatgttccgg tgaggaccgg
     1861 ggtgcggcgg acgctcatcg tggttgtctg cttcgccgcg ggtttcctcg tgagccgcgc
     1921 ggtgcggtgg gagacggaac ccgcgacgac accgcccacg ccgtggagca cggtgcccgc
     1981 ccaggagccc cggatcgacg cccgcgtcgc gcccggcgcg ctcgatgacg gcgcggggtg
     2041 ggtgctgatg gcggcggagg atctcgcccg cgccgagccg cccgacgacg tcgtcgactg
     2101 cggtgggctg cgggactggg cgttgcgcga aggtgcggtg cccgccggga acgctccgca
     2161 ctcgatcgag gtcacggcga actaccggac caccgtccag accgtgcacg ttcgcgtgct
     2221 gccggatccc acgccgtact ccgggaaacc gccgaccgtg cgactggcgt gcctaccgcg
     2281 cccggatgcc gtcctgccgt tccccgagcc cgacgcggcg cgggtcaagg tcaacggaga
     2341 gccctcactc ctcgacccgg tccagaagca gacgaccctg taccgcccgc acgaggtccg
     2401 gccccggtct ccagcggaac tggaggtcgt agtcgacctg accggttcga cggggccgtt
     2461 cgcctatcgc gtcgagatcg acgtcgtgga gcagaacgaa ttccggggga gggccgcgag
     2521 cggaccgctg ttcgccaccg aggacggtgg cgggatgggc tactggccgg cgaccgccac
     2581 gtggacgatg agcccctccc gcacccacgt ctactgcgag cccgtgacca acccgactcc
     2641 gggcacggag cccacctgca cctgaccact cctggccacg gccaggcgga agtagatctc
     2701 tcagcggcac cgggccggag cgcggccgtc tgctgtgggc cgtcgccgat cgatgggtgt
     2761 caccggcgga agccgggagt gggggatgcg tggcggtggg cggtggccag tgcggcggcc
     2821 agggcggcgg ctccaattgt ggtcagtgcc aaggggatgg ggagggcggg ggttggtggg
     2881 gtcgcgagga ttcccaccag cagggggagg gtcgtgctgc cggccatcga ggcggcgaac
     2941 aggaacgctg tcgcttgagg ggccgccggg gtccggccgg tcagccacgc taccgccacg
     3001 gggatcacgg gagccaggca cagacctgcc gcggtgtagg cgtaaggggt caggggcggg
     3061 atggtcgcga cggccagggc ggcagtggcc gcggccaggc agtagacgac cacgcggtgc
     3121 aggggctggg tcctggtcac cagggggatg acgatccggc ccagggcgag ggctgcccag
     3181 aacgcggaga cccagtgcac ggcggtgtcc ggcggcaggc cctgggagat caggtgggtc
     3241 gcctgccagg cacctacgcc ggtctccagt ccggcgtaga gcaggaccat cagggtgaag
     3301 ggggccagga ggccggcggg caggtggtgg cgggagggtg gcggtggggc gtggcgaggt
     3361 gcggcctggc cggcgggcag gcacagcagg gccagcacgc cgatcacggg gaatgccggg
     3421 gtgatcgtgg gcatccagcc gacggccagc gggccggtga tggtgcccgc tccgaaggcg
     3481 gcgttgagga agttgagcat gaggacgccg tcgaagcgct gcgcgaacgc gacgttgagg
     3541 tgcaggacgg caccgccgta gcccaggccg gtgacggcgc cggctgtcac gagcacgggc
     3601 caggtgtcgg cgagacccat gccgacgcag cccgccgcga acaggacgac ggacaagcgc
     3661 agcaccagag gacccggtaa ccggtgggcg aacaggccgc acagcgcgat ggcggtgaag
     3721 ccaccgaagc tgtagcacgc gatgagggag ccgccttcgc ctgccgccaa gccgtattcg
     3781 gcccgcagga cgggcagggc ggcacccagt gcggcggtga caccacccaa gaggacgaag
     3841 aaggcgaacg ccgcggcggt ggcggtgcgg gtgggttcag aagacatcgg gcagccacac
     3901 ctccgtccgg cgcgtgagca tccccatcag ctcgacgatc ccgtcgtcga gcggccccag
     3961 ggatcgggtc agggcgggcg ggtccagggt gccggcgtac caggcggcca gttgccccgg
     4021 cgacagggcg acggccccgg tgccgccggg gctggtgaca gccctgccgt cggctacttc
     4081 caggaccagg cgttgcgcgg cggggccggt gatggccaag tcgagtcggc cggtaacggt
     4141 tcgaggccag ccgcggctct ccaaggcggc ggggatgtcg agcagccgca gcatccacgg
     4201 gtaccagccc tgttcgcgca gttcgtgttg gggcagttcc cacaccagcg cgggcaggtt
     4261 cgccagcgtg ccggtgtcga agtggacggt gtgcgccatg ctgccgaaac cgccgaggaa
     4321 gcggagcagg gcgcggccgg acgccgtgtc gcgggcccag aagtcggaca cgaccaggtc
     4381 ctgcccccag ggttcgacgg ggcgcacgcg cacacccagc aggccctgtg gttcgccgcc
     4441 gaccacgagg gtgtagcagc ggtgctcgct gtcggagtac ttccagtccc accaccagga
     4501 cgggcggcgc agtgggccgt cccaggcgcg ggcgaggtcg cgttggagct ctcgcgcggg
     4561 ctcggtgaac ccgggcacca cgtcgccggg tgcggcgggc agtgaccgca ggccgcgcgc
     4621 gggcacggac caccgcctgc ccaggcccgc gacttcccag ccccaccgcc ggtagacgcc
     4681 ggtggcgggc gtccacaggg tgctgaggac accgccgtcg gctcgggtcc ggtccatgag
     4741 cgtgtcgatc acccggcggg cgacaccgcg gcctcgccac tcggggcgca cgcacacgtc
     4801 ggccacgcag ccggtgggca cggcgctgcc accgaagaac tggtgcgccc gcaacgccac
     4861 cgcgccgccg atcacctcgt cgtccacgac cgcgacggcg gcggggccgc gtgaccggtg
     4921 gcaggtgaga tcccggtggt cgccgccgaa cgactcggcg gccaggcggg agtactggtc
     4981 ccagtcgcgt tggtgccgag gcgcggtgac gatcggttca gacgtcacgg gcgctccccc
     5041 gccccaccgg caccgcctcg gacccgtgcg gttcccctcg ccggaggccg gctccacatc
     5101 ggacggtggc aggccggcga ccgccgggcg tcggtatcac cgggacgccg ccggcccgtg
     5161 ccgtcggcac cacccgttgc agcgggtcca gcgccgcacc aagcaggatc ccgcggaaac
     5221 ccgacataga ccgggccccc gtcgcgcggc ccgcccgggt gtcggcggcc cgagcctggc
     5281 gacacggacg cgatgtcgtc gtggacgtat ccggaatgca cgggcgtcac ctctctgacg
     5341 gggacgggtg tcgacaggtc gtgcggaccg cgtgcgcgac gcgacgtcac cccgtgcgca
     5401 gcgcgacttc acctcgcggg ccgaaccgga cgtgggccag gtccggcacg atcgcgtcgg
     5461 agccggtcag ctccgccggg tcgtgggtgg tgctcagcgc gaccgcgcgg atgcccgccg
     5521 cgcgggccgc ggcgaggccg gccggggcgt cctcgaacac cagcgctccg gccggttcga
     5581 caccggttcg gcggcagccg agcaggtagc cgtccggcgc gggcttgtgc tgctcgacgt
     5641 cggcggcggt cacgagcacg tccggggccg ggatgcccgc caccgcgagc cgggcggtcg
     5701 ccgcggggtg gtcgcaggag gtgacgatcc cccacctccg gcccaggcgg gtcagctcgg
     5761 ccgtcgcctc gcgcgccccg ggctgggcca cgacctcggt gacgtaccgc tcctccaggg
     5821 cgtcgacggc cgcggcctcc tccggggtgg ccaggtcggg cgcggcggcc cggaggtggt
     5881 ccgccgtggt gcgcccgtgg cccagcgcga aggtgcgctc ggcgtccagg ccgtgccggg
     5941 ccgcccactc gaaccaggcc ttggccacgc acccggagct gtcgaccagg acgccgtcga
     6001 ggtcgaacag gatcacgtcc gcgacgagga gggtcatcgg gccgctcgca gcgtgcccac
     6061 ggccgccggc gggccgccgt ggcgcggggc gaacaccgcg gaggccgcca ccaggacgtc
     6121 cgcgcccgcg tccacgagcc ggcccgcgcg ttcggcggtg acgccgccgt cggcgaccag
     6181 tcgcacgtgc tcgatcccgc gcttgaccag cagcgcgcgc agccggccga tcttgtccag
     6241 cacgtgcggc aggaagtcgc tggtgccggg gttgctggtc atcaggacga cctggtcgac
     6301 ctgctccagc acctcgtcca gcacgcccag cggggtcgcg gggttgagca ccacgccctt
     6361 gcggatgcca ccgccttcca gtccccgcag gaccgcggac aggtgctggg tgctctcgac
     6421 gtgcacggac accgtgtccg gagcgatgtc gaccaactcg tcgagcagcc tttccggctg
     6481 ctgcacctgg aggtggacgt ccaccggcag ggtcgtgcgc tcgcggatcg cgcggaccgt
     6541 gcgcagcccg aagttgatgt cgcgcacgaa gtgcccgtcc atcacgtcca cgtgcagcag
     6601 gtcggcttcg gcgcgttcca cgtcggcgat cgcgtcggcc agggcgagcg ggtcggcgcc
     6661 gagcagcgcc ggggcgatca tcaccatcgg gtcctctcgt tccacggggt ggtcagccgg
     6721 cgacgagccg gcgcgggcgg tgtccggtgg cggcgagcag cacgtccagc acgtagtcga
     6781 tctcggggcc ggtcaggtcg gggcggaccg gcaggcagag cgtgccccgc gcctgcgcct
     6841 cggcgttcgg gaacgacccg gtcagcccca ggtcggcgaa ggccggttgg cggtgcaccg
     6901 ggaccgggta ccgcacgacc acctcgacgc cgcgcgcggt catctcctcg aacacctcgt
     6961 cccgccggtc gaccgcgacc tggtagaggt ggaagacgtg ccgctgcccg gcgggcggcg
     7021 tggcggccac cccggtgccg gcgagggccc gcgcgtagtg gccggcgacc tcggcgcgcc
     7081 gcgcgttcca cccgtcgagc cggtcgagct tgtcgtcgag caccagggcc tggatgacgt
     7141 ccagcttgct gttgcacccc cggacgacgt ggtcgttctg ggcgcgctgg cccaggccgc
     7201 gcaacacctt gacccggcgt gcgatctccg ggtcgtcggt ggtgatcgct ccgccgtcac
     7261 cggccgcggc gaggttcttg ctcgggtgga agctgaagca gcccacccgg ccgaagccgc
     7321 ccacccgccg gcccgcccac ctcgcgccga cggcctgggc gcagtcctcg accaccgcca
     7381 ggccgtggcg gtccgcgatg gcgccgaggc ggtccatgtc cagcgcttgg ccgaacaggt
     7441 ggacggccag caccgcgcgg gtgcgcgggg tgacggcggc gtcgacctgg tccaggtcca
     7501 tcaggtggtc gccgggcgtg cagtcgacca gcacgggccg ggcgccgacc gcggtgatgg
     7561 cgagcaccga ggcgtggaag gtgttggcga cggtgatcac ctcgtcgccc ggtccgacgt
     7621 ccagcgcccg cagcgcgagc acgagggcgt cggtgccgga gttgaggccg acggcgtggg
     7681 ccacgccggt gtgcgccgcg aagcgctcct cgaagcgctc gacggcggga ccgaggatgt
     7741 agtcgccggc ggccagggcg tcgcggatgc gcgcggtcag cgcgtcgagg tcggcgaact
     7801 gggcgcggtg gtggtacttg gtgaccttca tggcgtggct ccacggtgtg ggaggacgac
     7861 gacgggcttg ccgacgaacc cgttctcggc gtggtccggc agggcggacg cggcttcggc
     7921 gagcgacatg cgacgggtgg tgagccgctc gacggcggcg ccggccgtcc agccgggtcc
     7981 ggtggcggcg agcaggccca gcgcccggtc gaagtccgcg cgcagcgcgc cgtgcgtgcc
     8041 ggccagcacg agcgggacgc ccgccaccga ggaccgctcg acgcgttccc ggcggcgcag
     8101 gtcgtcgagg tcgacgccgg ccagttccac tccggggcgg gtgcccgcga acagcagcag
     8161 cacgccgccg gggcgcacca tggcgagcgc cgcgtcgagg gcttcgggcg aggcggacgc
     8221 agtggccagc accacccggt cgaaccggcg gcccgccgcc ggtgccagca cgtcctcggg
     8281 caggacgtgg tgcgcccgca ggaagtccag ccgcgcggca ccgcggttga ccaggctgac
     8341 cggcacgccg tccgcgtgca gcaccgccgc gatcagcgtg cccgccatgc ccgcgccgac
     8401 gaccgccacg gccgaacgcc ggtcccctcc ggcgtcctcc agtcgccgca cgcagtggca
     8461 ggcgcacgcg agcggttcgg cgaacacggc gcggtcctcg ggcacggtgt cgggcaccgg
     8521 cacgagggcg ccgcgcacgg cctccggggc accctccagc tccactagtt cgccgtagcc
     8581 ggacgtgcgg gcgtgcagcg gcgggtgcgg gtcgaacacg acccgctgtc ccgccaccag
     8641 ccccagaccg tcggtgccgc cgaccacctc ggccacgatc tcgtggccga agtcgcgccg
     8701 caggtgccgg tcggaccgca gctcgcgcag gtccgaccgg cacacgccga cccggcgcgg
     8761 cgcgatgacg gccttggccg acgtcccgga cggctcggcg acgcgcgcct cgccgagcac
     8821 cacgcgcccg tcgtcgtggt ccagcctccg gtagggcgtc ccggtgggga tcacgcggtg
     8881 cctcccaact cgccgacggt cgtgaacagg tcgggcgcgc ggtgggcgcg gcccgtcatc
     8941 gtggggtcga ccagcacctt gatccgctcg gcgggaccgg cggacggagc tcgccgcgcg
     9001 gccagcgcgg gcagctcgtc ggcggcggcc tccagggaca ccacgtgcgt gaccaccggt
     9061 ccgaacgact cggggtggtc gagcagcagc cgctgcgccc gctccaggtg ccgccgtgcg
     9121 gtgccgcggt ggccggtgaa cccggccgcg ccccggcgca ccacgacgcc gggccgcggc
     9181 aggccgcacg cgttcgcgcg gcggacctcg ccgaggtcca cccccggcgc cgccgggtgg
     9241 cggtcgcccg gaccgaagcc gccgacgagg tccaccaccc cgtcgggccc gagcgcggcc
     9301 accgcctcgg tcagcgcggc gggcgcggct tcgcggggca ggcacaggaa agcggcgtcc
     9361 accggcaccc cgggcggccc ggtgtgcagg gaggtcgtgc cgaacatccc gcgcccggcg
     9421 aggaaccgca gccgttcttc gcgcgggtgc agcaggaagg tccggacgcc gcgcagctcc
     9481 ccgacgacgg cggcgagcac ggcggtgctg ccgccgcccc agacggccac cctcgcgggt
     9541 tcgcgctcga acagctccca gccgtagagc acggtggcca gcggttccac cagcggtgcc
     9601 aggtccgcga ccaggccggg cccggcggcc accagctccg ggccgtgctc gtcgaccacc
     9661 agccgctgct ggaacacgcc gtcgtagctg tggccgagca cccggtcctg gtcggtggcg
     9721 tccaccgggt tcagcacggc gtgccacggc acgccggtga ccgggtccgc cagctccacc
     9781 agggcctcgt gccccaggac ggtggccgcg tcgggccgca cccggcgctg gatctgcagg
     9841 tcggtgccgc acaccccggc gcgcagcacc cgtgccgcgc gttgaccggc gcggaccgcg
     9901 ggagccggcc tgctctccac gacgctgccc gtaccgcggc gcaccagcgc gaggttcacc
     9961 ccggtcgcca cggtcgcgcc ggtcgtctcg gccgtgccgg tcacgcgacc tcccgcagcc
    10021 ggtccagcgc cacccaggag cggtgggcgc ggtggatctc ctcgggggtc acgtcctcca
    10081 cgaacacccc gtggccgagc ccctgcggca gcgggaggtg ctggtgcccg tcgcggtgcc
    10141 gggtggcgtc ctccaggcac cggaccaact ggtccggggt gacgcccgac gtggtcaccg
    10201 gcaggccgat gaggcggagc agccggacca cgcgccggac ctcgtcctcg gacagcagac
    10261 cgcgcccctg ggcgatcagg cagcacagca ccatgtcgac ggcgaccgcc tcgccgtgca
    10321 gcagcgggtg gtcggcgttc agctcgaagc cggggctgaa cgtgtggccg aagtcgacca
    10381 gccgcctgag ctcctgctcc cacaggttgg gcgccagctc cgccagcatg ccgccgaccg
    10441 cgcgttcgat gatctccccg cccacgccgc cgtgcttgac cagctccacc acgtccgcgg
    10501 cgcggtcggc cagcaggtcg aacaggaccc ggtcgcggac cagggcgatc ttgacgatct
    10561 cggcgaggcc gttggcgacg tgccgcgtcg gcagcgtgcg caggaagctc tggtcgagca
    10621 gcgtggtggc ggccgggaag taggtgccga gccggttctt gtgcgagtgg tggttgatcg
    10681 cggtcttcac gccgaccgcg gcgtcgacca ggccgatcag cgtggtgggc acccggatga
    10741 acgggatgcc gcgccggtag aggctcgcgg cgagcccgac cacgtcggtc agcacgccgc
    10801 cgccgatggc gatgatcggg tcgctgcgcc ggttcaggcc ggccgcgtcc gccgcgtcga
    10861 ccacggcgta caccgactcg accgtcttgt tgggttcgtc ggtgggcagg gcgacgtagc
    10921 gcgcgtcgac ccgctggtgg cggaagtagg cgcggacgtc cgggccgtag agctgccaga
    10981 cctgccggtc caccaccacc aggcggcgcg cgcccgggtg cagcgcggcg gctcgggcca
    11041 ggtcccggtt gccggggtcc agcacccgat cggtctgccg gacgtcgtag ctgacctcct
    11101 gggtcgcgtt aacggtccag gacttcacgt cgttccccct tggtcaggtg cacgtcgatg
    11161 aggtcgagcg gggatcgggc cctgatgccc gctccccgca gtgcggcgag cccgtcgtcg
    11221 ctcgcgcggg tgatccgccg ggcgaagtag gccggatcgt cgatcccgta caggccgagc
    11281 gcggcgaggt tgcgcaggag gctgtcccgg tagtggtcgc cgagcccgtc gaccacgccg
    11341 ccgctgagca cggtgcgctc cacccccggg tcgaggaccg cttggtgcag cagcacttcc
    11401 gccaacggcc gggtgaagtc gtccagcagc gaccgggccc ggggatcacc tccgcgcacg
    11461 gcggcggtga acgcccccac gacgtcgtcg gggctccggt cccgcaacgg gcgcgcctcg
    11521 ggcagttctc gcagcagcgc ttcgatgccg cggccggagg agaacgcggc caggtggtcg
    11581 ggtgccccgc actcgcagtg cgcccgcact tcccggccga gcgccgtgaa ccgcgcgggc
    11641 aggtggccga tctcgccctg cacgccgtgg accgggtcga gcgggatgtg gccggtgcgc
    11701 aggtcgatgg tgcggcaggc gatcccgctg ctgaccgtga cggcggtcgc cctgcgcccc
    11761 ggcagcgagt gcgccagcag ctcgacggcg agggcggaca cgtcgttgag cacggtccac
    11821 cgcacgtcgg gcagcgcctc gcggagcgcg gcggcgaggt tgaacggtgc cgtcccgcca
    11881 ccccagagcg gtgcgctgcc cagcacctcg ccggtgtggc cgttcagcgc ggcaccgagc
    11941 gacacgccga ccgcgtcgaa cccgtgccgg cgccgctgct cgcgggtccg ctcgacgacg
    12001 aagtccacca ggtcggcctg caacccgggg acgggtttgg cggtgttgcg gtggttgacg
    12061 gccgggaccc ggcacagcag gcgcaccgcg cacgcgtcgg tgagcagccc gacccgccac
    12121 cagctccctc cgaggtcgaa ggccaggacg gggtgtcgcg gtcctaaagc gacagtgctc
    12181 accccgcccg ctcctcgccg gccgccgcct ggtccgcgaa cagctcaccg tcgacgccca
    12241 gcacgcgtgc ggcgggatcg gtgtcgggga cctctccccc gcgcagccgc gccaccgcgc
    12301 gcgccttggc cgcgcccgcg gcgagcacca ccctggtggg caccgaagcg agcaggtgca
    12361 cggccatgct gactcggacg gtgccctggt agggctgcgt gacgacgacc ggtgcgggat
    12421 cgtcgaccgc cgggtccccc gcgaacagcg acgcggtgtg gccgtcctcg cccaacccga
    12481 gcagggcgat gtcgggcacg ccgccagggg tcaggccggc gagcagcgcg gcgtagcggt
    12541 cgaccgcgcc gagcaggtcg tgcgcggcgg tgggcatggg gtgccaccgg gacggtgaca
    12601 cgcccgcggg tgtgatcagg ttgtcctcga tgacggccgc cgaggtcgcc ggtcggtcgt
    12661 cggtgacgcg ttcgtcggtc tggacgacgt gcacggcgtc ccagtccacg ccggccccgg
    12721 cgagcaggcg gtaggcccgc gcgggcgtgc tgccgccgga cagggccagc aggcaggttc
    12781 cgcgttcgcg caggacgtcg gagacccgac gggtgatcag gtcggcgacg gcggtggcca
    12841 tcgcctcccc gtcgtgaaaa gttctgcagc gcaacgtact tgtcgactgg cgcacagtat
    12901 cctccacagt ggagcgtggg atcaggtcgt ggcggtgtgt cgaaagcggt cgggcgggag
    12961 gggcgacggc cgcaccgccg tcgcgcacgt gcttgtgtca gctgaccggg ctcgtgccgt
    13021 tcctcgtcga aggcttcccg gtccggcggg tcgtgcccgc cgtgctcgcc cccatgccca
    13081 gacctccgtg aggcgttgtc cgcctgtcgg cggcgggtcg tcgcaggttt tgtactcccc
    13141 tagtgcaaaa taagggacat gtgccgatgg ccgcaattcg aggtcgcggg tcttccgctg
    13201 acagcgcgcg tgctgaacct cgtccacgag cgcggacggg tcgcccgcgc ggaggtcacg
    13261 agcacgctcg gagcggcccg cggcgcgacc ggcgacgcca tcgctgagct ggtcggactc
    13321 ggtctggtgc gggtctgcga accggtccgg gcgggcaccc gcggccgccc ctcgcccacc
    13381 ctcgcggccg agcccggcgg gccggtcgcc atcgcggcgc aagttacccc cattggacta
    13441 gaccttgccg tggtcggcct gcacgcggag atcgtcgcca ggcaccggct cgccctgccc
    13501 gaccacatcg acgacccggc gcgggtgatc ggcgcgctcg cccgcgccgt gacccgcctg
    13561 gccgaggagt ccggccgggc gtgcgtcggc gtcggcgtcg gcgtcgcggg gatggtgcgc
    13621 gacgaggacg gcctggtccg ctccgcgatc cacctggggt ggcgcgacgt gcccgccggg
    13681 gacctgctcg cggcggcggt gcccgccggg ctgccggtcg tggtccgccg ggacgcggcc
    13741 ctggtggcca tggccgagca ccggcacggg gccggccgcg acgcgggcac gctgctcgtg
    13801 gtcaccgggc accactgggg cgtcggcggc gcgctgctcg gcggcggcgt ctccccgcac
    13861 ggcacgcacc tcgaagtcgg ccacctggtg ctggacccgc gcggccggcg ctgcgcctgc
    13921 ggccagcggg gctgcctgga gacctacacc gacggcaacg ccctgctgcg cgcggccggg
    13981 ctgcccgagt ccgccgactc ggcggcgtcc gagcgcctgc tggactccgc gcgcgcgggc
    14041 gagccggccg cgctggccgc ggcggaggag gtggccaggc ggctgggcat cggcctgacg
    14101 agcctggtca acatcatcaa cccggaccgg gtggtgtgca ccggcacgtt cgcggccctg
    14161 ctcgccctgg cccgcgacga cgtgctgcac ccgtcccgcc ggtcggtcgt cgccaccctc
    14221 gacaacccgc acaccacgcc cggcgcggtc gaggacccgg tgctggtcgg cgcggccgaa
    14281 tcggtgttcc tgccgctgct gcgcgacccg cgcacccccc tgttccgcac cgaccgcccc
    14341 ggaggaggag tgccggcacc atgaccgcac cggacccggc cgaggtcgtc caccgccacg
    14401 ccctgcggct gctggcgacc gcccagaacg gcctgaccta cgccgacgac ccgtacgacc
    14461 gcgagcgcta ccaggaggtc cggcgggcgg cggaggggct gctcgccctg gtcgccaccg
    14521 gcgacctgcg cgaggtgcgg cggatcgtgg ccctggacac cggacacgcc acgcccaagg
    14581 tcgacgtgcg cggcgcggtc ttcgacccgg gcgggcgggt gctgctcgtg cgggagcgct
    14641 cggacggccg ctggaccctg ccgggtggct ggtgcgacgt cctggagtcg ccggccgagg
    14701 cggtcgcccg cgaggtgcgg gaggagtccg ggctgaccgt gcgggtcgcc aagctcgtcg
    14761 ccgtcctcga ccgcgagcgg cagggccacc gaccgcgctt cccgtaccac gtccacaagt
    14821 tgttcttcct gtgcgacgag gagtcccgcg gcgaacccga cccgacggag atctcggccg
    14881 tcgactggtt cgccctggac gcactgcccg agctgtccac ctcgcgggtg ctggaaccgc
    14941 aactgcacct ggcgcacacc cactggcacg accggaccct gcccaccgtg ttcgactgac
    15001 ggcgaggcgg gcgacaacgc cgccgcagcg cggaagtcgg ggcttcgcac ggcttgcccg
    15061 atcccgacgt gatcccgctg ctcaaccgtg cttccggacc ggatcgtggc actctgtccc
    15121 atcgtggacg acgaccgtcc cgccgaggaa ccgccgcgtc ggccgacagc cggacgtcgg
    15181 gtgatcaacg gattggtggt cgcgggactc gccatggtcg ggtggacgct cctgcgggcc
    15241 gacctgctgc cttcgccggg gtggttgtcc cggtggtggc ccgcggtggc gagcttgctg
    15301 ctgttcggcg tggcgttcgc ggtgtggcgc aagggccggg tgccgagggc ggccgagccc
    15361 gcggtccgcc gcgactggac ccaggtgatc accgccgcga ccgcgttggg cgcgctggtc
    15421 ttcaccgcac tgtccctgcg cgccgcccag gagcagatcg aggtcgccga acaggggcag
    15481 atcaccgacc ggtacgccaa ggccgtccaa ctgctcggcc cccggcgctg agcgcttcca
    15541 ggtgcggctg ggcggcacct acgcgctgga acgcctcgcc accgacgacg aagccgatcg
    15601 acctccgcga cacctgcctg gccgagctga tcgcgttcaa cgccgacctg accaggatgt
    15661 cgctcgtcgg cccggagtgg tcctcaccgg cgcgaagcac gacgacaaaa ccaacaccac
    15721 tggcgtgaag tacgacgcga ccactgtcgg ggcttggtgg tgagccagag cgcctcccgg
    15781 gtggcgatgc cttggtcgga gccgcagctc cggccgccgc agggtgccgc acccaagtgc
    15841 ggcacaccgt cagctcaccc cctccagcgc tgcctggacg aaccgggcga tccacggcga
    15901 ccggctgccc gccggccaaa ggaccagggt ccggtacggc gtcgcgtcgg gtaccgggcg
    15961 gtacgtcacg tcgggccgga cgttcagcgc ggccagcgaa ctcggcacca acgccacggc
    16021 ctggccaagt gcgaccacgt ccagcagttg ggcactgtcc cgcacgaccg ggccgtccgc
    16081 cgggcgatcc gggtttccca gccagtagtc gcggtcgacc acccccgggg cgctccaccg
    16141 gggcgcgggc tcggcgagca ggtcggcggt gctgaggacc tcgcgcccgg ccagctcgtg
    16201 tcctaccgcg agcgcggcga cgcgtggttc ggtcgccacc agctcggtgt cgaggccgtg
    16261 gccgtcgacg caggcggcga tggccaggtc cgcgcgcccg tcccggacca tgtcggcctg
    16321 ctcgccgaat ccgctcacca ccacccggat ctccggtgcg tccggatcag cccggaaccg
    16381 ttcgcggacc cggagcagca gccgcgtggc caccccgggt ttggcggtga ccacgagtcc
    16441 gcggaaggga aggccggcct gccgcgtccg gcggaccgcg gcgtcgaggg caccgagcac
    16501 ggcggcggcc tcctcgaaca ggatctcgcc ggcccgggtc agcgccagcc ggtgtccggt
    16561 gcggtcgaag aggtcgaccc cgagccgacg ttcgagctga cgcatggccc gggacagcgg
    16621 cggctgcgcg atgccgagcc gctcggccgc gcgggtgatg ttcaggtgct cggcaacggc
    16681 gcggaagtag cgcagttcgc ggatctccgg ctccggcata ccgccagggt atggggcggc
    16741 accgaaccgg tcgttctctt ccggcgcggc gtcggctgga gtggcgacat gaacgcgaac
    16801 gaagtagccc tcgtcaccgg cggcaacaag ggcatcggcc gggaggtggt ccgccgactc
    16861 gccggacagg gcttcaccgt ctacctcgga gcgcgcgatc cggagcgtgg ccactgcgcc
    16921 gtcgaggagc tgacgagcgc gccggacggt gcggcgcgga ccgccaagtc cggcgggcgc
    16981 ggcaacgggt tggacatccg gttcgtgcgg ctcgacgtcg gcgacgtggc atccgtccgg
    17041 gcggccgtca cgacgatcga ggccgcgacc ggacggctgg acgtgctggt caacaacgcc
    17101 gggatcatgg tcgagtggga cgtccggacc accgacatca cggccgcgca ccttcgcgag
    17161 gtgttcgagg tcaacgtctt cggcgtcgtc acggtgacat cggcctgttt gccgctgctg
    17221 cgtcgctccc ccaacccgcg cgtcgtcaac atgtccagcg ggctcgggtc gctcaccctg
    17281 ctgagcgacc cggagagccc tctcccggct cagggcttcc tcgcgtacag ctcgtccaag
    17341 gccgcgctca acgccgtgac cctgatctac gccaacgccc tgcgcgcgga cgggatcaag
    17401 gtcaacgccg ccagtcccgg tctggtgccg accgaccaga acgccgctgc gacgttcccg
    17461 cgcggcgacc gctccacagc cgatggcgcg gtcgtcccgg tactcctctc gacgatctcc
    17521 gccgacggcc ccaccggcgt cttccgcggg ccgaactccc tggacgacgt catcccgtgg
    17581 tgagcacccg accaagctcc cggacagggc gtcgtcacct cgtccgcgcc ggcttccggc
    17641 gatcgtcgtg cgggcgtcgg tcaggtgtcc tgttccaggc gtgcgcacac ggtttcgagg
    17701 accgccagag cggcggtcag ggcgggacgg cggccggtcg gggtgcgcca gacgccgtag
    17761 atgcggcgca ggggcggggc cgtcaccggg agcacccgga ccgacggcgg gagcgggcct
    17821 cggcccatgc gcgggaccag ggccaggccg aggccgacgc cgacgagtcc gatctggctc
    17881 gcgtactcgg tgacgatgtg ggtgaaccgg gtcgggttcg gggtgtgctg gaaggcgttg
    17941 agcaggaagt cgtgcgccac cgagccgggt tcgtagagcc accggtcgcc gcgcagctcg
    18001 tccaggtcca ccgacgcccg cccgaccagc gggtgggtgt ggtgggcgag cacgtcggac
    18061 aggtcgtcgc ccaggtgcct ggcctggagt ccctcgggca gggtcagcgg gatggccatc
    18121 cagtcgtgcg ccacggccag gtccgccgtg ccccgggcga ccagttcgac cgcccggtgc
    18181 gagtcggcct cgatcagccg cagcgacagg tccggccagg cgcgcgtcag ctcctcggtc
    18241 gcgccgggca gcacgccgcg cgtggcggtg gggaaggcgg cgacggtgag ggtgccggtg
    18301 acggtgtcgc tctgcgcctg gagctcggcg ctcatgctct ccagttcgac cacgatccgg
    18361 ctggccgact cggccaggac gcggccggcc ggggtcaggg tggtccggcc cgcctggtgc
    18421 tcgacgagct gctggtggac gtcgcggctg agcctggcga tctgctggga gatggcggac
    18481 ggggtgtagc cgagcgcgct ggcggcggcg gtcatcgatc cgtgcacggc gagggcctcg
    18541 atcgcgcgca gccccgccag gctcaccgtc agcacgtcgg cgtcacctca ctcccggtgt
    18601 ccgtccagtg ccgccatcct ggcacgacac cgccgcgaca ccaccactgt cactcgccgt
    18661 caccgccggt ggcggggagg tgcagcacgg cgtccacctc caccttgacc gagcgcagcc
    18721 cggccacgac cgtcgtgcgc gccggtttcc agtcgccgaa gtgcgcggcg tacgcgtggt
    18781 cgaactcggc gaagtcggcg acgtcggcca ggtaggcggt caccttcacc acgcaggtgc
    18841 ggtcgccgcc cgccgccgcg acgaccgcgg cgaggttgcg cagggcgagc gcggtctcgg
    18901 tggccacgtc ggcgggccgg taggagccgt cgggcaggcg tggcacctgg ccggacacgt
    18961 agacggtgtc gcccgcgcgc acgaacggcc ggtagtgccc ggcgggcggg atcaccggcg
    19021 ggccgccagg atcgccgagg acacctggaa ggcgttgaac cgctgcccgg tggcgaagtc
    19081 ggcgtcgatg cccgcgagga acgcgaacgc gggcgcgagc cgtgcgggcg gcacgatccc
    19141 gatccgcatc tcgtcggtgt agtgggagtc ggacatgggg gtgtcgatgg gccgcccggt
    19201 ggacatcgtg ttgaccgcga cgttgtgctc gcggccttcc agggcgagca ccttcatcag
    19261 cccttcctgg gcgtgcttcc ccggggtgta ggcggtttcc ttgacgaacc cggacagcgc
    19321 cgaccccgag gacaggaaca cgatgctgcc gtcgcgcgcc gcgaccaggt gcggccacac
    19381 ggtcttggtg agcacgtagg ccgcgccgag gatgatgtcg acctcgcgcc gccagtcctc
    19441 gaaggtgacg tccagcatgg acacctcctt gagcacggcg gcgttgtgga tcaacgcccg
    19501 gggcgggccg tagtgggcca acgccgtctc cgtcgcgtcc cgcgtggcgg ccgggtcggc
    19561 gaggtcgacc acgagcggca gcacgtccgc gcccgccgcg cgcagttctt cggtgagagc
    19621 ggccagtttc ccgccctgca cgtccatcag cgccacgcgc atcccggcgg tgacgagctc
    19681 gcgggcgatc tcccggccga gtccttcggc ggcaccggtc aggaacgcca ccttgccgtc
    19741 gacggcgatc acgaggacgc cccggccgcg gtgacccgga tcgcctcgga gagctggaag
    19801 gcgttgaacc ggtgcccgga ggcgaagtcc gcgtcgatgc cggccaggaa ggcgaacgcg
    19861 ggcgcgagcc gggacggcgg caccatcacg gcgcgctggg cgtcggtgta ggtgtaggcc
    19921 agcgggccgt ccacgggcgc gccgagggtg atggtgttga cggcgacgtt gtggtctttt
    19981 ccttccaggg cgagcacttt catcagtcct tcctggccgt gcttgccggc cacgtaggcg
    20041 gcctcgttcg cgaacccgga cagcgccgag cccgacgaga cgaacacgat gctgccgtcg
    20101 cgtgccgcga ccatgccggg ccacacggcc ttcgacagca cgaacgcgct ttgcaggatg
    20161 ctgtcgacct cggcggcgaa cgccgccccg tcgagttcca gcacgggggt ttcgcggaac
    20221 accgccgagt tgtgcacgag cagccggggc gtcccgaacc gctccaggac ctcctcggcg
    20281 cgggcgcgca ggacgtgcgg gtcggtgaag tcggtggtga acgcgtgcac ggacggcagt
    20341 tcgtcggcca gcgcgcgcac cgcgtcggcc tggtcgcaca gcaccgcgac ggtcatgccg
    20401 gcggcggcca gttcgcgggc gacggcgtgg ccgaggtctt cggcgttgcc ggcgacgagg
    20461 gcgaagcggc cggtggggtg ggtcatcgtg cggactcctc gacgatctcg gcgaccaggg
    20521 cgacgacctg gccgggtgac tcgatccggg ccagggtggg gcgcagcagg gcgagcgcgg
    20581 tgcgcgggaa cggggcgcgg aaggtctcca cgacctcgct ggtcaccggg tcgagcaggt
    20641 ggcccaggac ggtgtcgcgg cccaccacgg tgccgagggc ggcttcccgc agcaccggtt
    20701 ggtagacgcc cggccgggag gtcgacagcg ccaccttgcc ggtggccgcg gtgcccggct
    20761 cgtcgggcag gtcggcctcg gtcagcacgc ccgccttgcc cagcgcccgg cgcaggccgc
    20821 gggtgacggc ggcggcgcgg tcctcctcga actcgccgcg cccgccggcc tcgatccaca
    20881 ccgcgacggc gccctgggcg cgggcgtgcc cggtgaggct ggaggcgcgg tcggggccgt
    20941 cgaggatgag cggggtgccc atccactcgg ccaggtgctc gctgccgggg aaccggtagg
    21001 tgaagcagtt gatgttccag ctcccgccgc cgtgcacgtc caggacgacg tcggcgccgt
    21061 cgacggcgtg ctcggccagc acggcggcca gccgctgggt gtgcgagccc gccgggtcgc
    21121 cggggaag
//
