LOCUS       NC_019673              23675 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Saccharothrix espanaensis DSM 44229, complete sequence.
ACCESSION   NC_019673
VERSION     NC_019673.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Saccharothrix espanaensis DSM 44229
  ORGANISM  Saccharothrix espanaensis DSM 44229
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Saccharothrix.
REFERENCE   1
  AUTHORS   Strobel,T., Al-Dilaimi,A., Blom,J., Gessner,A., Kalinowski,J.,
            Luzhetska,M., Puhler,A., Szczepanowski,R., Bechthold,A. and
            Ruckert,C.
  TITLE     Complete genome sequence of Saccharothrix espanaensis DSM 44229(T)
            and comparison to the other completely sequenced Pseudonocardiaceae
  JOURNAL   BMC Genomics 13, 465 (2012)
   PUBMED   22958348
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9360653)
  AUTHORS   Rueckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2012) IGS, CeBiTec, Bielefeld University,
            Universitaetsstr. 27, D-33335, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000328705.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:06:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,451
            Genes (coding)                    :: 8,313
            CDSs (with protein)               :: 8,313
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 43 of 138
            Pseudo Genes (incomplete)         :: 116 of 138
            Pseudo Genes (internal stop)      :: 7 of 138
            Pseudo Genes (multiple problems)  :: 27 of 138
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:45:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4850223
            Orig. end                         :: 4873898
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE804045.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23675
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="oligosaccharide"
                     /region_number="19"
                     /rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /tool="antismash"
     cand_cluster    1..23675
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /kind="single"
                     /product="oligosaccharide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23675
                     /aStool="rule-based-clusters"
                     /category="saccharide"
                     /contig_edge="False"
                     /core_location="[10000:13675](+)"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13675
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(repeatable(3, [DUF1205, Glyco_transf_28,
                     Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT,
                     150))"
                     /neighbourhood="10000"
                     /product="oligosaccharide"
                     /protocluster_number="1"
     gene            631..1593
                     /locus_tag="BN6_RS21490"
                     /old_locus_tag="BN6_44380"
     CDS             631..1593
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101831.1"
                     /locus_tag="BN6_RS21490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44380"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_015101831.1"
                     /transl_table=11
                     /translation="MDLAAVRTFVAVVDEGRFQRAAEDLAISQQAVSKRIAALEKELGV
                     RLFTRTAQGARLSADGEAFLPHARDLLDAAGRAVASVRPERRALRVDVIGRKLAPADLL
                     RDFHRAHPEVELHVVTLHDADAATAALLAGTVDASFRAAGALPPGIEAVRVLDEPIQLL
                     TGPRHEFAEAGAVRPADLAGRRIWMPGIAGTEWGEFYEGLAAEFGFTLDPVGPHYGTEP
                     LLDVITRSADLAAFVGGQTRLLRAPEHDLRRVDLHHPTPVYPHSVLWRAGNPHPALAAL
                     RGYLGSRPALPDSWAPGPLSGRADARPAPPHPPGPRNPR"
     gene            complement(1529..2545)
                     /locus_tag="BN6_RS21495"
                     /old_locus_tag="BN6_44390"
     CDS             complement(1529..2545)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /function="Thioredoxin reductase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1176: alkyl hydroperoxide reductase subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101832.1"
                     /locus_tag="BN6_RS21495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44390"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_015101832.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.9e-19, bitscore:
                     67.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDQLGDSYDVVVVGGGAAGLNGALMLARSRRSVVVVDAGEPRNA
                     PADGVHGLLGREGTPPAELLARGRDEVRSYGGHVVPGRVDAVAFADDGFAVTLADGRAV
                     RARRLLVATGLVDELPAVPGLRERWGREVLHCPYCHGYEVRDRAVGVLAGGPMSVHQAL
                     LFRQLTDDVTYFANGAEPAADETERLAARGIRIVAGQVAAVEVADDRLTGVRLADGTVV
                     ARDALVVAPRMVARVGFLRAIGLHPVEHPSGAGEHLAADPTGRTDVHGVWVAGNSADLA
                     AQVGAAAAAGAMAGAQINADLVAEETRLAVDAYRDPVTAGSGAREGAAVPGERPHGR"
     misc_feature    2590..2605
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.91"
                     /tool="antismash"
     gene            complement(2622..3200)
                     /locus_tag="BN6_RS21500"
                     /old_locus_tag="BN6_44400"
     CDS             complement(2622..3200)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101833.1"
                     /locus_tag="BN6_RS21500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44400"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_015101833.1"
                     /transl_table=11
                     /translation="MAEIPGRRARKKAATRQALADAALRLFLERGFDQVTVAEIAAAAD
                     TAVSTLFVHFPGGKEALVLGDGGERAEALTAAVRDRPAGGSVLDALRDFLATRGPFAAD
                     LDPDHRRRTRLVVETPALRAHARKLWTDNEAVLARVIAEETGGDPAELSLRLLARFVLE
                     VPDLAALEPDPRAALRTAFAHLRAGWPDL"
     misc_feature    complement(3229..3238)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    complement(3231..3246)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.4"
                     /tool="antismash"
     misc_feature    complement(3235..3253)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    complement(3236..3249)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.09"
                     /tool="antismash"
     misc_feature    3237..3250
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.26"
                     /tool="antismash"
     misc_feature    complement(3244..3258)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.9"
                     /tool="antismash"
     misc_feature    3258..3272
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.27"
                     /tool="antismash"
     gene            3258..4211
                     /locus_tag="BN6_RS21505"
                     /old_locus_tag="BN6_44410"
     CDS             3258..4211
                     /NRPS_PKS="Domain: PKS_KR (27-140). E-value: 1.8e-07.
                     Score: 23.2. Matches aSDomain:
                     nrpspksdomains_BN6_RS21505_PKS_KR.1"
                     /codon_start=1
                     /function="Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101834.1"
                     /locus_tag="BN6_RS21505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44410"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_015101834.1"
                     /transl_table=11
                     /translation="MIPTMVGGVTRADSVWDVHRLPRADDRTFLVTGGNAGIGYFVAEQ
                     LAGTGAEVVLGSRDPAKARAAMAAIRAQVPDARLRHLPLDLADLPRTTGWPDRLDAVVL
                     NAGVLLDDPRRREIPDGHELMFATNHLGHFGLTALLAPVLTPDARIVTTGSFTAKSEHL
                     DFADLESTRDYRPKPAYARSKLAQMLTGFELDRRLRAAGSAVRSVVTHPGGALDGLTPA
                     RPAVHAGRSARTLPAALLLHGKHAGAWTSVRAVLDPTVEGGDLWGPRFLGFRGRPHRER
                     VRGPLADLDAAARLWAISAELTGTDPDFPAQTGAPR"
     CDS_motif       3339..3431
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS21505_0001"
                     /evalue="1.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN6_RS21505"
                     /protein_end="58"
                     /protein_start="27"
                     /score="18.2"
                     /tool="antismash"
                     /translation="TFLVTGGNAGIGYFVAEQLAGTGAEVVLGSR"
     aSDomain        3339..3677
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS21505_PKS_KR.1"
                     /evalue="1.80E-07"
                     /label="BN6_RS21505_PKS_KR.1"
                     /locus_tag="BN6_RS21505"
                     /protein_end="140"
                     /protein_start="27"
                     /score="23.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TFLVTGGNAGIGYFVAEQLAGTGAEVVLGSRDPAKARAAMAAIRA
                     QVPDARLRHLPLDLADLPRTTGWPDRLDAVVLNAGVLLDDPRRREIPDGHELMFATNHL
                     GHFGLTALL"
     gene            4208..5335
                     /locus_tag="BN6_RS21510"
                     /old_locus_tag="BN6_44420"
     CDS             4208..5335
                     /codon_start=1
                     /function="2-polyprenyl-6-methoxyphenol hydroxylase and
                     related FAD-dependent oxidoreductases"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101835.1"
                     /locus_tag="BN6_RS21510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44420"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_015101835.1"
                     /sec_met_domain="DAO (E-value: 6.6e-07, bitscore: 28.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHHNVAVVGAGLSGLTLARVLHRHGVDAAVYEQEPSRHTRAQGG
                     MLDIHDDTGAVALHAAGLHDEFRALVLPKGQETRVLDRHGVVHLAEQDDGTGDRPEIDR
                     GHLRDLLLDALPAGTVRWGARVRTAQRIGDHHEVTLADGTTFSTDLLVGADGAWSRIRP
                     LVSPATPAYTGVSFVELDLPDADARHPAAAALVGGGMMFALGAGQGFLAHRESGGDVHV
                     YAALTVPEEWIAGVDFADTAAAKAVLLDRFADWDASLRAVIADAEGDLVPRPIHALPVG
                     HRWDHVPGVTLLGDAAHLMSPFAGEGANLAMLDGAGLGLALAAHPGDPDEAVTAYETAL
                     FPRGESSAAASAAGQAACFRDDAPQGLLDLFAAHR"
     misc_feature    5429..5447
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.77"
                     /tool="antismash"
     gene            5528..6355
                     /locus_tag="BN6_RS21515"
                     /old_locus_tag="BN6_44430"
     CDS             5528..6355
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101836.1"
                     /locus_tag="BN6_RS21515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44430"
                     /product="DUF4253 domain-containing protein"
                     /protein_id="WP_015101836.1"
                     /transl_table=11
                     /translation="MTSETSPDLAALFPDADARRPLSIPLPPGRLVVPEDEERPVLWLS
                     DAPPRLDLWRRLRAEHPESGLWPLMLEPLHDNEEFRPWGVGELATAGMSSPDGHDAEAL
                     LSRWWAGHTSGESPEDDQRGLTAPFGRQWPGLAAPSAGTADPGAEADDVAEVLGSVLDS
                     MRLGLVAAGRGADALTAVGWTGPVNYTGDTAEISAVVRGWEDRFGARVVGVGFATLYLS
                     VANRPATMEDALRVAAEHFAFCPDNFWQGRRSETLTTYAERLLSDEGWTFWWD"
     gene            6346..7032
                     /locus_tag="BN6_RS42190"
                     /old_locus_tag="BN6_44440"
     CDS             6346..7032
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013003.5"
                     /locus_tag="BN6_RS42190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44440"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_148302956.1"
                     /transl_table=11
                     /translation="MGLGPLPRNGTGARAWRVRWDGERTAAVMAGLRADLAHRRSSPKA
                     PFDPPASPFGTTPGGLLDYRGLRLTEPIRHARVEGVDFAAGTLADGGQFDSDFTSCVFD
                     QAVLRGTFLGRSFTRCSFREARLDRCRLPATFTDCSFAGARLRGVVASGQTFTRCDFTG
                     AQLHRSHFDHCTFIDCSFDGITTGLASMGGSTFVGEVDLGLFTGTVLDHVRHDPAPPGT
                     RPPSAP"
     gene            complement(6959..7480)
                     /locus_tag="BN6_RS21525"
                     /old_locus_tag="BN6_44450"
     CDS             complement(6959..7480)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /function="Predicted transcriptional regulators"
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101838.1"
                     /locus_tag="BN6_RS21525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44450"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_015101838.1"
                     /transl_table=11
                     /translation="MRKDVRSTCPVNLSLEVFGDRWTLLVLRDVVFGGARHFRELLGGP
                     ERISSNILTDRLAALVEHGLLTRAGDPSHKQKVVYSLTERAIQLVPVLVQISAWGARHL
                     PVAEQYAARTGVLVAGGPPLWEVFMDELREDHLGTRLAPAPAGPTVRERMEAAYQAVLD
                     RAGRGPGPCR"
     misc_feature    complement(7538..7552)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.77"
                     /tool="antismash"
     misc_feature    complement(7539..7551)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
     gene            7571..8350
                     /locus_tag="BN6_RS21530"
                     /old_locus_tag="BN6_44460"
     CDS             7571..8350
                     /codon_start=1
                     /function="Uncharacterized protein conserved in bacteria"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101839.1"
                     /locus_tag="BN6_RS21530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44460"
                     /product="DUF899 domain-containing protein"
                     /protein_id="WP_015101839.1"
                     /transl_table=11
                     /translation="MSLPEIVSRSDWLAARIQLLAQEKALTKARDRLNAERRRLPMVRV
                     DKPYAFVGPDGEVGLLDLFEGRSQLVLHHFMWTYDIDAEGREHPRDVACSSCSTTADGI
                     AGLTQLHVRDTTLVAVSRGPYDKIAAFRERMGWNFPWYSSAGSDFNHDFHATVDERSAP
                     VLLNYRTEAELAEAGTPWSAARRGDYPGLSAFLRDGDTVYHTYSTFARGIESAVGVSHY
                     LDLTALGRQEPWEEPKGRAVPLGLHAGGPEIRLPDEY"
     gene            complement(8374..9255)
                     /locus_tag="BN6_RS46820"
                     /old_locus_tag="BN6_44470"
     CDS             complement(8374..9255)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS46820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_44470"
                     /product="hypothetical protein"
                     /protein_id="WP_015101840.1"
                     /transl_table=11
                     /translation="MDQPGLPGDPTTWREFRGALKKLMKRSEVTALAIERMSVDAIARS
                     RGAESTSDATVGRKIADKEQEVDARSVRTIVVACALSVERRGGLPVDADVDAWLRARTR
                     LVEAGIGAGEPVTPAVERRRRWSRARIAWLAVAVAVAVAAVAGGVAVAAGAWRSEPVRQ
                     SSCATSPDRVATDGLTMGSPASDTVVTGDSVEAGGTVDLAPGERPPWLLLHAISACKYY
                     LVGPTTVSGRSWTGTLYVDPAQHGVFGAYAVVVGEAEDDRLHQLAAAGRSPFIEQLPDG
                     ARVVGVTVRCCA"
     misc_feature    complement(8989..8991)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9296..9311)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.82"
                     /tool="antismash"
     gene            9362..9901
                     /locus_tag="BN6_RS21540"
                     /old_locus_tag="BN6_44480"
     CDS             9362..9901
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012859.5"
                     /locus_tag="BN6_RS21540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44480"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_015101841.1"
                     /transl_table=11
                     /translation="MLRKLWTMVAVAVFSAVIPAGTALADDEVVYIVSRANNRCLDATA
                     QWNGVNGTPIQLWDCYPPTQYNQMWRIHWVSDYEFQLIGVASGRCLDATGMGTAAGTRL
                     QLWDCLGPNQRNQIWKSLSTNTPGYRWIMGQHSAKVVDAVANQTGSNGTPVQLWHLIGD
                     ETQTNQRWAFKRPGDF"
     gene            10001..>10916
                     /locus_tag="BN6_RS21545"
                     /old_locus_tag="BN6_44490"
                     /pseudo=""
     CDS             10001..>10916
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glyco_transf_28"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1102: glycosyltransferase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981173.1"
                     /locus_tag="BN6_RS21545"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="BN6_44490"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="Glyco_transf_28 (E-value: 6.5e-13,
                     bitscore: 47.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLTTRGSRGDVEPLAGLAVALRELGTEATVCAPPDEEFAVPL
                     ERVDVPLVPLGPTVRSVVAGPKPPTAQDAFRLAPALVAARFEVPGAAARGCDALPATGL
                     MPAGARDVAEKQGIPYVLACFHLLGLPSRHFAPGARPGTPSPEGETDHRVLWEQDAQRV
                     NALYGEALDSHRAAISLPPVDNVRDHVLTGRPWPAADPVLCPSQGMTELDVVQTGAWIL
                     TDDRPGLGGPGRDRRRRRLLHRRRGQPAGAVPPGGGGRAPRRRGHHDDGGPSRCAPGDR
                     APDRGPAVLGGSRGGVGRRRGARG"
     misc_feature    10936..10950
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            11005..11634
                     /locus_tag="BN6_RS21550"
                     /old_locus_tag="BN6_44500"
     CDS             11005..11634
                     /codon_start=1
                     /function="Methylase involved in ubiquinone/menaquinone
                     biosynthesis"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101843.1"
                     /locus_tag="BN6_RS21550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44500"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_015101843.1"
                     /transl_table=11
                     /translation="MTDPETRAAYDAVAALYAELFSDVLETLPLERALLGAFAELVRVH
                     DAGPIADIGCGPGHVTAHLHGLGASTFGIDLSPEMVALARQAHPGLRFDVGSMTALDLA
                     DGVLGGILASYSTIHTRPEHLPAVFAEFERVLAPGGHLLLGFFAGDDPLPREFDHKVAP
                     AYRWSPDSLADLLRQAGFAEVGRLRREPFEHERQFHQAQLLVRKNP"
     gene            11822..12682
                     /locus_tag="BN6_RS21555"
                     /old_locus_tag="BN6_44510"
     CDS             11822..12682
                     /codon_start=1
                     /function="Uncharacterized conserved protein"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101844.1"
                     /locus_tag="BN6_RS21555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44510"
                     /product="NYN domain-containing protein"
                     /protein_id="WP_015101844.1"
                     /transl_table=11
                     /translation="MGEGARIGVFYDGTWFAYLSDFYATEHPRAARIALDGFHDSLRWY
                     VHTETGLPLDVCTVEEAHYVRGRIDTPATSFDAALAVAGIVRHDLPLHGGKEKGVDVHF
                     ALEVWERATTARLQWVVLVTGDSDFTPLATRLTARGIRVVVPVVDIRSSPLPPAWTPRT
                     AAPLRAAASRTPGFDALFAPADRADYPLRPPFVRSAGVAASAVGSPRGRRRGTVTGWRA
                     GQPHGFITDTRGGSWFVSSDDLPDGRSALATGTPVSFTGSPTPNPGRKYPRAYSVQPEP
                     ADRRA"
     gene            12710..13675
                     /locus_tag="BN6_RS21560"
                     /old_locus_tag="BN6_44520"
     CDS             12710..13675
                     /codon_start=1
                     /function="Glycosyl transferases, related to
                     UDP-glucuronosyltransferase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: MGT"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     oligosaccharide: Glyco_transf_28"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101845.1"
                     /locus_tag="BN6_RS21560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44520"
                     /product="glycosyltransferase"
                     /protein_id="WP_015101845.1"
                     /sec_met_domain="Glyco_transf_28 (E-value: 7.9e-07,
                     bitscore: 28.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="MGT (E-value: 1.7e-64, bitscore: 217.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFASLASVGHTYPLIPLAIAARDAGHEVHFAAGEDVHGPLAA
                     HGLRPFRPADSFYEIYAEDLAPELARLRPDLVVHEWGLPGAADAARAAGIPGLWHGFGR
                     MFPAGIGLERPAPGRPHLDICPPSLQDPDFLATAERIPLRPVAFCEPGALPERGGPPLV
                     YLTLGTAFGTPEVLATAIRGLAALGAQVVVATGRVPVEQVGPVPGNVILRPWVPQADLW
                     PHVDVVVHHGGSGTTLGALAAGVPQLFLPQGADQFANADAVCVAGAGLRLLGDELSADA
                     VADHVRALRRGYRDAARAIAEEIARMPSPDEVARALPDLA"
     misc_feature    complement(12758..12771)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            complement(13824..14366)
                     /locus_tag="BN6_RS21565"
                     /old_locus_tag="BN6_44530"
     CDS             complement(13824..14366)
                     /codon_start=1
                     /function="Dihydrofolate reductase"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101846.1"
                     /locus_tag="BN6_RS21565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44530"
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_015101846.1"
                     /transl_table=11
                     /translation="MSDVDTGKVVVNRAMSLDGFIAGRGHAMDWIGEHLTPDVFPEVMA
                     ATGAMLVGRGTYEVAKGMAPQDTAYDGGVQFVLTHQPPDEPDPTVTFLTCGIEEAVATA
                     RAAAGGKNLEILGADVAAQCLGRGLVDEILVYVLPVLLGDGVRFSPPSLDRVELEPFAN
                     TQSGAVTMLRFRVRKQS"
     gene            complement(14486..14671)
                     /locus_tag="BN6_RS48990"
     CDS             complement(14486..14671)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1197:
                     autoinducer-binding transcriptional regulator,"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.5"
                     /locus_tag="BN6_RS48990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_084672913.1"
                     /transl_table=11
                     /translation="MIGELHQGTPPLTDRERDVLRCLAKGYDNREIADTLGIAVRTVNR
                     HLENIRAKLGHRRRSD"
     gene            complement(14696..14824)
                     /locus_tag="BN6_RS49700"
     CDS             complement(14696..14824)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS49700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_269454268.1"
                     /transl_table=11
                     /translation="MITPDDGPRTTALLKARLGTVLEAVTEEWHWYDGRPNSLIRF"
     gene            complement(14821..15474)
                     /locus_tag="BN6_RS21570"
                     /old_locus_tag="BN6_44550"
     CDS             complement(14821..15474)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101848.1"
                     /locus_tag="BN6_RS21570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44550"
                     /product="hypothetical protein"
                     /protein_id="WP_231904719.1"
                     /transl_table=11
                     /translation="MRLGRDSYRVIRPEHPVVHASLYEGRYGPRLAVDKAATVDLAFAW
                     WPAARSPRSLVYLPVRSGAPTCGEDYGGEGRKLDLVLLHHSLRFPVSRWKQVRARLAPS
                     AAHTVTLPPNAFPVFSREEHRTDNHREFKDHLRWAVAADTLFLVGSRLAYEREADRVRG
                     LAEDGPAQVVGHPETYCCTEITLGQWKMSAAHQRNPSAELHVDRCHEHWPAPQR"
     gene            complement(15605..15895)
                     /locus_tag="BN6_RS21575"
                     /old_locus_tag="BN6_44560"
     CDS             complement(15605..15895)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101849.1"
                     /locus_tag="BN6_RS21575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44560"
                     /product="DUF4235 domain-containing protein"
                     /protein_id="WP_015101849.1"
                     /transl_table=11
                     /translation="MSLIRVLYKPLGPLLGVAGGLVAGRLSGHLWKLVSGDDEPPAANR
                     KDRGWGEVLFAATLQGAVFGLVKAAVDRGGATLFDKVTGEWPGDTGDDDKS"
     gene            complement(15892..16338)
                     /locus_tag="BN6_RS42195"
                     /old_locus_tag="BN6_44570"
     CDS             complement(15892..16338)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023697.5"
                     /locus_tag="BN6_RS42195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44570"
                     /product="DUF3618 domain-containing protein"
                     /protein_id="WP_015101850.1"
                     /transl_table=11
                     /translation="MSGKDIPDDTAQLRADIEKTRRELGDTVEALAHKADVPARVKESV
                     HDGVDKAKEAAGEAKTKAKEAAGEAKARAGQAVTRAAAETQLAADSLAHKATAAAAHAV
                     ESLPPPVQEKVVLVREQAGRRPAAVVGGLIAAVLLVTWLVRRGR"
     gene            complement(16335..16721)
                     /locus_tag="BN6_RS44940"
                     /old_locus_tag="BN6_44580"
     CDS             complement(16335..16721)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800830.1"
                     /locus_tag="BN6_RS44940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44580"
                     /product="phage holin family protein"
                     /protein_id="WP_231904720.1"
                     /transl_table=11
                     /translation="MSETSTSDLVRDVTRQTSRLVREEIRLAVAEISEKGKHVGLGVGL
                     MGAAGVLAWFGVGTVVAGLVLTLALVLPAWAAAFVVAALVFLVAGVLVLLGRKQVTEGT
                     PPLPEEAIEGVKRDISTVTERAHR"
     gene            complement(16811..17737)
                     /locus_tag="BN6_RS44945"
                     /old_locus_tag="BN6_44590"
     CDS             complement(16811..17737)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020674064.1"
                     /locus_tag="BN6_RS44945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44590"
                     /product="DMT family transporter"
                     /protein_id="WP_041313557.1"
                     /transl_table=11
                     /translation="MLSPSRAGLGWGLVGVAAFSFTVPFTRVVVGGGMSPLFVGSGRAV
                     VAAVLAAGALAATRQRLPRGGQWARLAVVAGGVVVGFPLLTSFALTSASAGHSAVVIAL
                     LPAVTAVIAVLRGRERPPRSFWVMAAVGAAAAVVFASLRGDGIGGPHWSDLLLLGAVLA
                     AGIGYAEGGLLARELGAWQTVSWALVLSAPLMAALAGFAVVRQPPTGTPGEWAAFGYLA
                     VVSMFLGFFAWYRGLAIGPMAQVSQVQLVQPVMTICWAALLLGEQLTWSTALGGVAVIA
                     CAAVAVRARLGATQVGTGQGLPVDREG"
     gene            17775..19175
                     /locus_tag="BN6_RS21595"
                     /old_locus_tag="BN6_44600"
     CDS             17775..19175
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (103-443). E-value:
                     6.4e-21. Score: 66.8. Matches aSDomain:
                     nrpspksdomains_BN6_RS21595_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011873789.1"
                     /locus_tag="BN6_RS21595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44600"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_041313561.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.3e-19, bitscore:
                     66.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDSSARIAAGVRDWVAAAAPGAKLPSTRALVARYAASPVTVQK
                     ALRTLAAQGLIESRPGVGTFVRAVRTTRPNDYGWQTAALGSPGFRATQRSTALRTTPND
                     VIALHSGYPDRELLPERLVRAAFTRAARGDAAVTRPPTAGLPELQAWFATELGAFGGAP
                     PSPGEVVVFPGSQSALCTVFRALVGPERPLLVESPTYWGALLAAAQSGVRVVPVPSSAH
                     GPDPDELARAFSRTGARAFYAQPNFANPTGAQWSPDLAEKVLDVVRRHGAFLVEDDWAH
                     DFGITADPVPLAARDDGGHVVYLRSLTKSVSPAVRVAGIVARGPARERILADVEAVSMY
                     VSGVLQAVALDVVTQPAWRTHRRDSRHRLAARRDLMVAALHEHVPAARLEAVPHGGLNL
                     WVRLPDGTDLARLVRDCDAAGVVVAPGNEWFPAEPTGAYLRLNYSGPNPGAFPDGVRTV
                     GSALARQT"
     aSDomain        18084..19103
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS21595_Aminotran_1_2.1"
                     /evalue="6.40E-21"
                     /label="BN6_RS21595_Aminotran_1_2.1"
                     /locus_tag="BN6_RS21595"
                     /protein_end="443"
                     /protein_start="103"
                     /score="66.8"
                     /tool="antismash"
                     /translation="DVIALHSGYPDRELLPERLVRAAFTRAARGDAAVTRPPTAGLPEL
                     QAWFATELGAFGGAPPSPGEVVVFPGSQSALCTVFRALVGPERPLLVESPTYWGALLAA
                     AQSGVRVVPVPSSAHGPDPDELARAFSRTGARAFYAQPNFANPTGAQWSPDLAEKVLDV
                     VRRHGAFLVEDDWAHDFGITADPVPLAARDDGGHVVYLRSLTKSVSPAVRVAGIVARGP
                     ARERILADVEAVSMYVSGVLQAVALDVVTQPAWRTHRRDSRHRLAARRDLMVAALHEHV
                     PAARLEAVPHGGLNLWVRLPDGTDLARLVRDCDAAGVVVAPGNEWFPAEPTGAYLRLNY
                     "
     gene            complement(19351..20943)
                     /locus_tag="BN6_RS21600"
                     /old_locus_tag="BN6_44610"
     CDS             complement(19351..20943)
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101854.1"
                     /locus_tag="BN6_RS21600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44610"
                     /product="amidohydrolase"
                     /protein_id="WP_015101854.1"
                     /transl_table=11
                     /translation="MTAADLVILGATVHTMDPQRPLASAVAVRDGLVVAVGDDLPIGSR
                     TEVVDGSGLVVTPGLVDSHQHPLHGVADAGGVDAAGLTTPVRLRDLLRRAADGLPPDGW
                     VVVNGVEYPALPDRPRQFLDDAVAGRPAFLWLADSHTALMSTRALHLAGITGPIDFGDR
                     SEIVVDEDGVPTGQLHEMSAVLHGYAAVPSPSTEHIARLAADLFADQAACGITAIHVPD
                     SWAGTEAVLDALEAQGRLPLRVLRAPWMFPARIEETLDALRGARADDRAKLWRTGAVKF
                     FLDGTIDGGSAWLGHPDCAGDGTRPMWTDLGRYRDAVRRAAALGLPSFTHAIGDRAVTE
                     ALDTYQAVGRPARGRHRVEHAELLADDDVTRFAGLDVVASMQPTHLDWTLPDHTDNWSE
                     RLGPDRCGHGWRCADIVRAGGRVALGSDWPVAGYDPRVVMAGARLRRPAAEHGRAPVGA
                     DQALTARQSLAGYTTWAAYGSGEEQVAGRIREGFRADLTVFRGDPLTVPAEELADLPVE
                     LTVVAGRVAHRAG"
     gene            complement(20940..22469)
                     /locus_tag="BN6_RS21605"
                     /old_locus_tag="BN6_44620"
     CDS             complement(20940..22469)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101855.1"
                     /locus_tag="BN6_RS21605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44620"
                     /product="APC family permease"
                     /protein_id="WP_015101855.1"
                     /transl_table=11
                     /translation="MIEDPTSRTAPPPAANPETAADDARLRALGYEQRLSRRLGVLGNI
                     GMGFATVSPVVGLYAVVLVGMTVAGPAWVWALPVCLLGQCLLLTVYSELASEFPVSGGA
                     YQWSRRLIGPGFAWMTGWLSLCGPLVANTTIGYLSAPWILGLFGITPTPNLLVAVAAGF
                     IVVCALVNTFGIDVLRRVLALGVAAEAVASVLIGVVLLLAFREQPFSILTATLGAEAGS
                     AGSVPAALLAALAVGGWAFIGFDACVATSEETRNAARHVPRAIWWALLSVGALVILNAF
                     ATTLVHPDLPSVVAGLDPDPVSTAVIASFGSWSAKPFVVVVVVAFFACGLASQGSTARG
                     VYSMARDGVLPLSRLMSAVSRRQVPIGAVVAVTVVGCAGLLLAVNSAAIGSLIAFGTAV
                     LYLTFFLTALAALIARLRGTWVPAGYVRLGRTGTVINALAVGWLGFEFVNIAWPRAILA
                     PVGAPWYQIWAAPLVSAVVVLAGLLYLLIARPQDKVLVSASFATRVEGIDR"
     misc_feature    22583..22601
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.27"
                     /tool="antismash"
     gene            22601..22957
                     /locus_tag="BN6_RS47970"
                     /old_locus_tag="BN6_44630"
     CDS             22601..22957
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019520.5"
                     /locus_tag="BN6_RS47970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_44630"
                     /product="PucR family transcriptional regulator
                     ligand-binding domain-containing protein"
                     /protein_id="WP_197540169.1"
                     /transl_table=11
                     /translation="MPLTVNALLAVRDLHLALVAGATGRDRVIEAAHVSELARPGEWLH
                     GGELLMTAGVVLPTDPESCRGYVRDVVDGGAAALGFGVGHGQPHLAPPARWWPPPRRPG
                     CRCWWCRTRCRSSR"
ORIGIN
        1 acagcaggta gctcgcagcg ttcgcggcga ccgtgaccac cgggccgaac accccgaccg
       61 ccaggccgcc cagtggcggc cccagcgcgg tggcggtcca cgtcgtggcc tcgaaccggc
      121 cgttcgcgat cagcaggtct tccttgccca ccaacgactt caggtaggcg ccactggccg
      181 cccggaacgc gatgtccgag gccgcgacca ccaccgacac caccacgagc tgaccgaaac
      241 ccaaccaccc ggccaggtgt gccaccggca cgctcgccac cgccgcgaac cggaccaggt
      301 cggtcgcgac catcaccggg cgcttgcggc ggaactccac ccacggcccc agcggcaccg
      361 ccacgaccgc gcccaccgca cgtccgaccg ccgccagcgc cgacacctcg accggcccgg
      421 cgtgcagcac caggaccgct atgagggtga aggcgtcgaa cgcgaggcac gcgccgaacg
      481 tgctcaccgc gaacgacgcc cacagccacc cgaaccgccg tcccatcccc cacctccgga
      541 cgagatccaa gcgaccggac ggccggtgcg gcaaacaacc ccgcgggcac cggggcacaa
      601 ccggcggttg tgcggctagg gtcctgcggc gtggatctcg ctgccgtgcg caccttcgtc
      661 gccgtagtgg acgagggccg gttccagcgg gccgccgagg acctggcgat cagccagcag
      721 gcggtgtcca agcggatcgc cgcgctggag aaggaactcg gcgtgcggct gttcacccgg
      781 accgcgcagg gcgcgcggct gtcggcggac ggcgaggcgt tcctgcccca cgcccgggac
      841 ctgctcgacg ccgccgggcg ggcggtggcg tcggtccggc ccgaacggcg ggcgctgcgg
      901 gtggacgtga tcggccgcaa gctcgcgccg gccgacctgc tgcgcgactt ccaccgcgcg
      961 caccccgagg tcgagctgca cgtggtgacc ctgcacgacg ccgacgccgc gaccgccgcc
     1021 ctgctcgccg gcacggtcga cgcctcgttc cgggcggcgg gcgcgctgcc gcccggcatc
     1081 gaggcggtcc gggtgctcga cgagccgatc cagctgctca ccggcccgcg ccacgagttc
     1141 gccgaggcgg gcgcggtgcg gccggccgac ctcgccggcc ggcggatctg gatgcccggg
     1201 atcgcgggca ccgagtgggg cgagttctac gaggggctcg ccgccgagtt cgggttcacg
     1261 ctcgacccgg tcggcccgca ctacggcacc gagccgctgc tggacgtgat cacgcgctcg
     1321 gcggacctgg cggcgttcgt gggcgggcag acccggctgc tccgggcgcc cgagcacgac
     1381 ctgcgccggg tcgacctgca ccacccgacg ccggtctacc cgcactcggt gctgtggcgg
     1441 gcgggcaacc cgcacccggc actggccgcg ctgcgcgggt acctgggctc ccggcccgcc
     1501 ctgccggaca gctgggcgcc cggcccgctc agcggccgtg cggacgctcg cccggcaccg
     1561 ccgcaccctc ccgggccccg gaacccgcgg tgaccgggtc ccggtaggcg tcgacggcca
     1621 gtcgggtctc ctccgcgacc aggtcggcgt tgatctgcgc gccggccatg gcaccggcgg
     1681 cggcggccgc gccgacctgc gcggccaggt cggccgagtt tcccgcgacc cagacaccgt
     1741 gcacgtcggt ccggcccgtc gggtcggcgg ccaggtgctc gcccgccccg gacgggtgct
     1801 cgaccgggtg cagcccgatc gcgcgcagga agccgacccg ggcgaccatg cgcggcgcga
     1861 ccaccagcgc gtcgcgggcg accaccgtgc cgtcggccag tcgcacgccg gtcagccggt
     1921 cgtcggcgac ctcgacggcc gcgacctgcc cggccacgat ccggatgccg cgcgcggcca
     1981 gccgttcggt ctcgtcggca gcgggttccg cgccgttggc gaagtaggtg acgtcatcgg
     2041 tgagttgccg gaacagcaac gcctggtgga ccgacatcgg cccgccggcc agcacgccga
     2101 ccgcccggtc ccggacctcg tagccgtggc agtacgggca gtgcaggacc tcgcgccccc
     2161 accgctcgcg cagccccggc acggccggca gctcgtccac caggccggtg gcgaccagca
     2221 gccgccgcgc gcggaccgcg cgcccgtcgg ccagcgtcac ggcgaacccg tcgtcggcga
     2281 aggccaccgc gtcgacccgg ccgggcacga cgtggccgcc gtaggatcgg acctcgtccc
     2341 gtccgcgcgc cagcagttcg gccggcgggg tcccctcccg gccgagcagt ccgtgcacgc
     2401 cgtcggcggg ggcgttgcgg ggctcgccgg cgtcgaccac caccaccgag cgccgcgagc
     2461 gggccagcat caaagccccg ttcaagccgg ccgccccgcc gccgaccacc accacgtcat
     2521 agctgtcacc cagctgatcg gtcatcacga ccacctccgc gacccacctt gcgacccggc
     2581 cgcgagttcc gcacgttttg ttgccgttcc ggcaagtggc ctcagaggtc cggccacccc
     2641 gcgcggaggt gggcgaaggc ggtgcgcagc gcggcccggg ggtcgggctc cagggccgcg
     2701 aggtccggga cctccagcac gaaccgggcg agcaggcgca gcgagagctc cgccgggtcg
     2761 ccgccggtct cctcggcgat cacccgggcg agcaccgcct cgttgtcggt ccagagcttg
     2821 cgggcgtggg cgcgcagcgc gggggtctcg accacgagcc gggtgcgccg ccggtggtcg
     2881 gggtccaggt ctgccgcgaa cgggccgcgg gtggccagga agtcgcgcag ggcgtcgagg
     2941 accgacccgc ccgcgggccg gtcgcgcacc gccgcggtca gcgcctcggc gcgctcgccg
     3001 ccgtcaccga ggacgagcgc ctccttgccg ccggggaagt gcacgaacag cgtggagacg
     3061 gccgtgtcgg cggcggcggc gatctcggcg acggtgacct ggtcgaaccc gcgctccagg
     3121 aacagccgca gcgccgcgtc ggccagcgcc tgcctggtcg ccgccttctt gcgcgcacgc
     3181 cggcccggga tctccgccat gccgaccacc ctaacaaacc cgaggcgctc caaaatcata
     3241 ctgattgcaa actcggaatg attccgacta tggtcggtgg cgtgaccaga gcagacagcg
     3301 tgtgggacgt ccaccgactc ccgcgcgccg acgaccggac gttcctggtg accgggggca
     3361 acgcgggcat cggctacttc gtcgccgaac agctcgccgg gaccggggcg gaggtggtgc
     3421 tcggcagccg ggacccggcg aaggcgcggg ccgcgatggc ggcgatccgc gcgcaggtcc
     3481 ccgacgcgcg gctgcggcac ctcccgctcg acctcgccga cctcccgcgc accaccgggt
     3541 ggcccgaccg gctcgacgcc gtcgtgctca acgccggggt cctgctcgac gacccgcgcc
     3601 gccgggagat cccggacggc cacgagctga tgttcgcgac caaccacctc gggcacttcg
     3661 ggctgaccgc cctgctggcc ccggtgctca cgccggacgc gcggatcgtc accaccggca
     3721 gcttcaccgc gaagtccgag cacctcgact tcgccgacct ggagagcacg cgggactacc
     3781 ggcccaaacc cgcctacgcg cggtcgaagc tcgcgcagat gctgaccggt ttcgaactcg
     3841 accgccggct gcgcgccgcc gggtcggccg tccgcagcgt cgtgacccac cccggcgggg
     3901 cgctcgacgg cctcaccccg gcccgaccgg ccgtgcacgc cggccggtcg gcgcgcaccc
     3961 tgccggccgc cctcctgctg cacggcaagc acgccggcgc gtggacctcg gtgcgggccg
     4021 tgctggaccc gaccgtcgag ggcggcgacc tctggggccc ccggttcctc gggttccggg
     4081 gccggccgca ccgcgagcgc gtgcgcggac cgctggccga cctcgacgcc gccgcccggc
     4141 tgtgggcgat cagcgccgaa ctgaccggca ccgaccccga cttccccgca cagaccggag
     4201 ccccccgatg acccaccaca acgtcgccgt cgtcggtgcg ggcctgagcg gtctcacgct
     4261 cgcccgcgtc ctgcaccgcc acggcgtcga cgccgccgtc tacgaacagg aaccgtcacg
     4321 gcacacccgc gcacaaggcg ggatgctcga catccacgac gacaccggag ccgtcgcgct
     4381 gcacgccgcc ggcctgcacg acgagttccg cgcgctggtg ctgcccaagg gccaggagac
     4441 ccgcgtcctg gaccggcacg gcgtggtgca cctcgccgag caggacgacg gcaccggcga
     4501 ccggcccgag atcgaccggg gccacctgcg cgacctcctg ctcgacgcgc tgcccgccgg
     4561 caccgtccgc tggggcgcga gagtccgcac cgcacaacgg atcggcgacc accacgaggt
     4621 gaccctggcg gacggcacca cgttcagcac cgacctcctg gtcggcgcgg acggcgcgtg
     4681 gtcccggatc cggccgctcg tctcccccgc gacgcccgcc tacaccggtg tgtccttcgt
     4741 cgaactcgac ctgcccgacg ccgacgcccg ccacccggcg gcggcggccc tggtcggcgg
     4801 cggcatgatg ttcgccctcg gtgcgggcca aggcttcctg gcgcaccgcg agtccggcgg
     4861 cgacgtgcac gtctacgccg cgctcaccgt tcccgaggag tggatcgccg gcgtcgactt
     4921 cgccgacacc gccgccgcca aggcggtgct gctggaccgg ttcgccgact gggacgcgag
     4981 cctgcgggcg gtgatcgccg acgccgaggg cgacctggtc ccccgcccga tccacgccct
     5041 gccggtcggc caccgctggg accacgtccc cggcgtgacc ctgctcggcg acgccgcgca
     5101 cctgatgtcg ccgttcgccg gcgagggcgc gaacctggcg atgctcgacg gtgccggact
     5161 cggcctggcc ctggccgcac accccggcga ccccgacgaa gccgtcaccg cctacgaaac
     5221 cgcgctgttc ccgcgcggcg agtcctccgc cgcggcctct gccgcagggc aggccgcctg
     5281 cttccgcgac gacgcaccgc agggcctgct cgacctgttc gcggcccacc gctgacgccg
     5341 gcccgttcaa gcagttccac cagcgccgag cccggtgcca gccaacgagt tcagggtcca
     5401 gtccaccgga tcggctgcgc cgcgtcgcgc tgcgaccggt tctccacgcc gagatcgcgc
     5461 gtccgtccac acgtgacagc aggggtgcca cgcggggcac gccgcacggc cacctaacat
     5521 ccgtgaggtg acctcggaaa catcgcccga cctcgccgcc ttgttccccg acgcggacgc
     5581 ccgtcgaccg ctgtcgatcc cgttgccgcc ggggcggctg gtggtgcccg aggacgagga
     5641 acgcccggtg ctctggctca gcgacgcgcc tccgaggctc gacctgtggc ggcggttgcg
     5701 cgccgagcac cccgagtccg gcctgtggcc gctgatgctg gaaccgctgc acgacaacga
     5761 ggagttccgc ccctggggcg tcggcgaact cgccacggcc gggatgtcct cgccggacgg
     5821 ccacgacgcc gaggcgctgc tgtcccgctg gtgggccggc cacacctcgg gcgagagccc
     5881 cgaggacgac cagcgcgggc tgaccgcgcc gttcggccgg cagtggccgg gcctggccgc
     5941 accctcggcc ggcaccgcgg accccggcgc ggaggccgac gacgtggccg aggtcctggg
     6001 gtcggtcctc gactcgatgc ggctgggcct ggtggccgcc gggcgcggcg cggacgcgct
     6061 gaccgccgtc ggctggaccg gtccggtcaa ctacaccggc gacacggccg agatctccgc
     6121 cgtcgtgcgc gggtgggagg accgcttcgg cgcgcgggtg gtcggggtcg gcttcgccac
     6181 gctgtacctc agcgtcgcga accgaccggc cacgatggag gacgcgctcc gcgtcgccgc
     6241 cgagcacttc gcgttctgcc cggacaactt ctggcagggc cgcaggtccg agacgctgac
     6301 cacctacgcc gaacgactcc tgtccgacga gggctggacc ttctggtggg actaggtccg
     6361 ttgccgcgca acggaacggg ggcgcgggcg tggcgcgtcc ggtgggacgg cgagcggacg
     6421 gccgctgtca tggccgggct gcgcgctgat ctggcgcacc gccggtcgtc gccgaaagcg
     6481 ccgttcgacc cgcccgcgtc cccgttcggc accaccccgg gcggtctgct cgactaccgg
     6541 ggtctgcggt tgaccgagcc gatccggcac gcgcgggtcg agggcgtgga cttcgccgcc
     6601 ggcacgctcg ccgacggcgg ccagttcgac tcggacttca cgtcgtgcgt gttcgaccag
     6661 gcggtgctgc gcggcacgtt cttgggccgt tcgttcacgc ggtgctcgtt ccgcgaagcg
     6721 aggttggacc gctgccggct gcccgcgacg ttcaccgact gctcgttcgc cggcgcacgt
     6781 ctgcggggcg tggtcgcgtc cggtcagacg ttcacccggt gcgatttcac cggggcgcaa
     6841 ctgcaccgca gccacttcga ccactgcacg ttcatcgact gctcgttcga cggcatcacg
     6901 accggcctcg cctcgatggg cggcagcacg ttcgtcggcg aggtcgactt gggcctgttc
     6961 accggcacgg tcctggacca cgtccggcac gatccagcac cgcctggtac gcggcctcca
     7021 tccgctccct gacggtcggg ccggccggcg cgggcgccag ccgcgtgccg aggtggtctt
     7081 cccgcagttc gtccatgaac acctcccaca gcggcgggcc gccggcgacg agcacgcccg
     7141 tgcgcgcggc gtactgctcg gccaccggga ggtgccgcgc gccccacgcg ctgatctgga
     7201 cgagtaccgg caccagctgg atcgcccgct cggtcaggct gtagacgacc ttctgcttgt
     7261 gcgacgggtc gccggcccgg gtcagcagcc cgtgctcgac cagcgcggcc agccggtcgg
     7321 tgaggatgtt cgaggagatc cgctccggcc cgccgagcag ttcgcggaag tgccgggcac
     7381 ccccgaagac gacgtcccgg agcaccagca gggtccagcg gtcgccgaag acctccagcg
     7441 acaggttgac cgggcacgtc gaccggacgt ccttgcgcac cggacccacc tccgcaccgg
     7501 ttgcgttctc gaaccagtct cccctaccgt gggaccactt gcaaaacgag atcagttcga
     7561 ggaggcccgg atgtccctgc ccgagatcgt gtcccgttcc gactggctcg ccgcccgcat
     7621 ccagctgctg gcccaggaga aggccctcac caaggcgcgc gaccggctca acgccgagcg
     7681 ccgccggctg cccatggtcc gggtcgacaa gccctacgcg ttcgtcgggc cggacggcga
     7741 ggtcggcctg ctcgacctgt tcgagggccg gtcgcagctc gtgctgcacc acttcatgtg
     7801 gacctacgac atcgacgccg aagggcgtga acacccccgt gacgtcgcct gttcgagctg
     7861 ctcgacgacc gcggacggca tcgccggcct gacccagctc cacgtccgcg acaccacgct
     7921 ggtcgccgtc tcgcgcgggc cgtacgacaa gatcgccgcg ttccgcgagc ggatggggtg
     7981 gaacttcccc tggtactcct ccgccggcag cgacttcaac cacgacttcc acgccaccgt
     8041 ggacgagagg tccgcaccgg tcctgctcaa ctaccgcacc gaggccgaac tggcggaagc
     8101 cggcacgccg tggtcggcgg cccggcgcgg cgactacccc ggcctgagcg ccttcctccg
     8161 tgacggcgac accgtctacc acacgtactc gacgttcgcc cggggcatcg aatcggccgt
     8221 cggcgtgagc cactacctcg acctgaccgc cctcggccgc caggaaccgt gggaggagcc
     8281 gaagggacgc gccgtcccgc tcggcctcca cgccggcggc ccggagatcc ggctccccga
     8341 cgagtactga cctgccgcca ccaggccgca ggctcaggcg cagcaccgca cggtcacgcc
     8401 gaccacgcgg gcgccgtccg gcaactgctc gatgaacggc gacctgcccg ccgccgcgag
     8461 ttggtgcaga cgatcatcct cggcctcccc caccaccacg gcgtaagcgc cgaaaacccc
     8521 gtgctgggcg ggatcgacgt acaacgtgcc ggtccacgaa cgtccagaca ccgtcgtcgg
     8581 ccccacgagg tagtacttgc acgccgagat ggcgtgcagt agcagccacg gtggacgttc
     8641 gccgggcgcg aggtcgaccg tgccgcccgc ctcgacggag tcgcccgtga ccacggtgtc
     8701 cgacgccggc gagcccatcg tcaggccgtc ggtcgccacc cggtccggcg atgtggcgca
     8761 ggacgactgc cgcaccggtt cggaccgcca ggcaccggct gcgacggcca ccccgcccgc
     8821 caccgcggcc acggcgacgg cgacggcgac ggcgagccag gcgatgcgcg ccctgctcca
     8881 ccgacgacgt cgttcgacgg ccggagtgac cggttccccg gcaccgatgc cggcttcgac
     8941 cagccgcgtg cgggcccgca gccacgcgtc gacgtcggcg tccacgggta agccgcccct
     9001 ccgttccacg ctcaacgcgc acgcgacgac gatcgtccgc acggatctgg cgtcgacctc
     9061 ctgttctttg tcggcgattt tccgaccgac cgtggcatcg gaggtgcttt cggctccccg
     9121 actccgcgcg atcgcgtcga cggacattcg ttcaatcgcg agcgcggtca cctccgaccg
     9181 cttcatcagc tttttcaacg cgccgcggaa ctcccgccag gtcgtcgggt cgccgggcag
     9241 cccaggttgg tccatgggcc cagcctccca cgtgttccca ccccttccca cggcgttgac
     9301 cagtcggttc accgccgaga cagtggctcg aactgttcag ctgggatgag ggaggggttc
     9361 cgtgctcagg aaactgtgga ccatggtcgc ggtggccgta ttcagcgcgg tgataccggc
     9421 gggcaccgca ctcgccgatg atgaagtcgt gtacatcgtg agccgcgcca acaaccggtg
     9481 cctggacgcc accgcgcaat ggaacggggt gaacggcacg ccgatccagc tctgggactg
     9541 ctacccaccg acccagtaca accagatgtg gcggatccac tgggtctccg actacgagtt
     9601 ccagctgatc ggcgtcgcca gcggccggtg cctcgacgcg accggcatgg gcaccgccgc
     9661 cggcacccgg ctgcaactgt gggactgcct cggcccgaac cagcgcaacc agatctggaa
     9721 gtcgttgtcc accaacacac ccggctaccg gtggatcatg gggcagcact cggccaaggt
     9781 cgtggacgcg gtcgccaacc agaccggctc caacggcacc ccggtgcagc tctggcacct
     9841 gatcggcgac gagacgcaga ccaaccagcg gtgggccttc aagcgtcccg gcgacttctg
     9901 aggtgaccgg cgagccgggc cgtcgcgcct ggctcgccct tcgccgcggc gaaggcggaa
     9961 ttcggcctga ggccgggacc tggggaaacg gggatcgaac gtgcgggtgc tgttgacgac
    10021 acggggatcg cgcggagacg tcgaaccgct cgccgggctc gcggtggcgc tgcgggaact
    10081 cggcacggaa gcgacggtgt gcgcgccgcc ggacgaggag ttcgcggtgc cgctggaacg
    10141 ggtcgacgtg ccgctggtgc cgctgggccc gacggtgcgc tcggtcgtcg ccgggccgaa
    10201 gccgccgacg gcgcaggacg cgttccggct cgctcccgcg ctggtcgccg cgcggttcga
    10261 ggtgcccggc gcggcggcac gcgggtgcga cgcgctgccg gcgaccggtc tgatgccggc
    10321 cggggcgcgg gacgtggccg agaagcaggg catcccgtac gtgctcgcgt gcttccacct
    10381 gctcgggctg ccgtcgcggc acttcgcgcc gggtgcccgg ccgggcaccc cgtcgccgga
    10441 gggcgagacc gaccaccggg tgctgtggga gcaggacgcg cagcgggtca acgccctgta
    10501 cggcgaggcg ctcgacagcc atcgggcggc gatcagcctg ccgccggtgg acaacgtccg
    10561 cgaccacgtc ctgaccggcc ggccgtggcc ggcggcggac ccggtgctgt gcccgtcgca
    10621 gggcatgacg gaactcgacg tcgtgcagac cggcgcgtgg atcctgaccg acgaccgccc
    10681 ggggctgggc gggcctggcc gcgatcgacg acgccgacga ctgcttcacc gtcggcgagg
    10741 tcaaccagca ggcgctgttc cgccgggtgg cggcggtcgt gcaccacggc ggcgcgggca
    10801 ccacgacgac ggcggcccga gccggtgcgc cccaggtgat cgtgccccgg atcgcggacc
    10861 agccgtactg ggcggctcgc gtggcggagt tgggcgtcgg cgtggcgcac gagggctcga
    10921 cgtcggccgg tgaccatcag atgggccgat ctgaacgatg ccccacgcca cccggtcacc
    10981 caagagccgc ttagggtttt gcccgtgacc gatcccgaga ccagggcggc ttacgacgcc
    11041 gttgccgccc tctacgccga actgttcagc gacgttctgg agaccttgcc gttggaacgc
    11101 gcgctgctgg gcgcgttcgc cgaactcgtg cgggtccacg acgccgggcc gatcgccgac
    11161 atcggctgcg ggcccggcca cgtgaccgcg cacctgcacg ggctcggggc gagcacgttc
    11221 ggcatcgacc tctccccgga gatggtcgcg ctggcccggc aagcccatcc gggcctgcgg
    11281 ttcgacgtgg gttcgatgac cgccctggac ctcgccgacg gggtcctggg cggcatcctc
    11341 gcgtcctact cgaccatcca cacccgaccg gagcacctgc cggccgtgtt cgccgagttc
    11401 gagcgggtgc tggcaccggg cggccacctg ctgctcgggt tcttcgccgg cgacgacccg
    11461 ctgccgcggg agttcgacca caaggtcgcg cccgcctacc ggtggtcccc ggacagcctc
    11521 gcggacctgt tgcgccaagc cgggttcgcc gaggtcggcc ggctgcggcg ggagcccttc
    11581 gagcacgagc ggcagttcca ccaggcccag ctgctggtcc gcaagaaccc ctgaccgccg
    11641 tgcccacccc gccggctgcc cgttcgcctg gcctggtcac ggggccgccg ataccaggtc
    11701 gagaggcact gccgccgggg tgggagtcca ctgtggccgt accggatcgc cctccacacc
    11761 ggacgggctc gtggagcggg tgtcgtgctc gggttcggcg cggtgcgggt aaactggggc
    11821 ggtgggggaa ggcgcgcgca tcggggtgtt ctacgacggg acgtggttcg cctacctgag
    11881 cgatttctac gccaccgagc acccacgggc ggcacggatc gcgttggacg ggttccacga
    11941 ctcgctgcgc tggtacgtcc acaccgagac ggggctgccg ctcgacgtct gcaccgtgga
    12001 agaggcgcac tacgtccgtg ggcggatcga cacgcccgcc acgtcgttcg acgccgcgct
    12061 cgcggtggcc gggatcgtcc ggcacgacct cccgctgcac ggcggcaagg agaagggcgt
    12121 cgacgtccac ttcgcgctcg aagtctggga gcgcgccacc accgcgcggt tgcagtgggt
    12181 ggtgctggtc accggcgact cggacttcac cccgctggcc acccggctga cggcgcgcgg
    12241 catccgggtg gtcgttccgg tggtggacat ccgttcgtcg ccgctcccgc ccgcgtggac
    12301 gccgcgcacc gccgcgccgc tgcgggccgc tgccagtcgg acgccggggt tcgacgcgct
    12361 gttcgcgccc gccgaccgtg ccgactaccc gctgcggccg ccgttcgtcc gctccgccgg
    12421 ggtggcggcg tcggcggtgg gctcgccgcg cggacgccgg cgcggcacgg tgaccgggtg
    12481 gcgggccggg cagccgcacg ggttcatcac cgacacgcgc ggcgggtcgt ggttcgtctc
    12541 cagcgacgac ctgccggacg gccgttcggc gctggccacc ggcacgccgg tgtcgttcac
    12601 cggctcgccg acgccgaacc cgggccgcaa gtacccccgg gcgtactcgg tccagcccga
    12661 accggccgac cggcgggcgt gagcaccggc acgcgtaggt tctgcggcca tgcgcgtgct
    12721 cttcgccagt ctcgcctcgg tcggccacac ctacccgttg atcccgctcg cgatcgccgc
    12781 ccgcgacgcc gggcacgagg tgcacttcgc cgccggcgag gacgtgcacg ggccgttggc
    12841 ggcgcacggg ctgcggccct tccgcccggc ggactcgttc tacgagatct acgccgagga
    12901 cctcgcgccg gagctggcgc ggctgcggcc ggacctggtc gtgcacgagt gggggctgcc
    12961 gggtgcggcc gacgccgccc gcgccgccgg gatccccggt ctctggcacg gtttcggccg
    13021 gatgttcccg gccggcatcg ggctggaacg gcccgcgccg ggccgcccgc acctcgacat
    13081 ctgcccgccg tcgttgcagg acccggactt cctggcgacc gccgaacgga tcccgctgcg
    13141 gccggtcgcg ttctgcgaac ccggcgcgct gcccgagagg ggcgggccgc cgctggtcta
    13201 cctgacgctc ggcaccgcgt tcggcacccc tgaggtcctc gccacggcca tccgggggct
    13261 ggcggcgttg ggcgcgcagg tcgtggtcgc gaccgggcga gtcccggtgg aacaggtcgg
    13321 gcctgtgccg ggcaacgtca tccttcggcc ctgggtgccg caagcggacc tgtggccgca
    13381 cgtcgacgtg gtggtgcacc acggcggcag cggcacgacg ttgggtgcgc tcgccgccgg
    13441 cgtgccgcag ttgttcctgc cgcagggagc cgaccagttc gccaacgccg acgcggtctg
    13501 cgtggcgggt gccgggcttc gcctgctcgg cgacgaactg agcgcggacg ccgtcgccga
    13561 ccacgtgcgg gccctccggc gcgggtaccg ggacgcggcg cgcgcgatcg ccgaggagat
    13621 cgcccgcatg ccgtcaccgg acgaggtggc ccgcgccctg ccggacctcg cctaggacgt
    13681 ccgctgtggt caccgggtgg acggccgggt gaccacagcg tccggcgcac ggccggagcg
    13741 ccgccagtgc ccttcgcggg agggcaccgg cggcggcggt ggcgcgaagc cggagagctg
    13801 taccgaagct agccggcaga gggctacgac tgcttgcgca cgcggaagcg gagcatcgtg
    13861 acggcaccgg actgggtgtt ggcgaacggt tccagctcga cccggtcgag gctggggggc
    13921 gagaagcgga cgccgtcgcc gagcagcacc ggcaggacgt acaccaggat ctcgtccacg
    13981 agaccgcgtc ccaggcactg ggcggccacg tccgcgccga ggatctccag gttcttgccg
    14041 cccgcggcgg cgcgggcggt ggcgacggct tcctcgatgc cacaggtgag gaacgtgacg
    14101 gtggggtccg gttcgtcggg cggttggtgg gtgaggacga actgcacccc gccgtcgtaa
    14161 gcggtgtcct gcggggccat gcccttggcg acctcgtagg tgccccgacc cacgagcatc
    14221 gcgcccgtgg ccgccatgac ctccgggaac acgtccgggg tgaggtgctc gccgatccag
    14281 tccatcgcgt ggccgcgacc ggcgatgaag ccgtcgagcg acatcgccct gttcacgacc
    14341 accttgccgg tgtccacatc actcatgcgc ctgctccccc gttctcgcga gcccgagtgc
    14401 cggatcatag ttgcgggcag gcgggagcga cgtgatcggt cgcggtcgcc gcgtcagccg
    14461 agtgcctcac ggcgggcaat tcggatcagt cggaccggcg gcggtggccc agtttcgcgc
    14521 ggatgttctc caggtggcgg ttgaccgtgc ggaccgcgat gcccagggtg tcggcgatct
    14581 cgcggttgtc gtaacccttg gccaggcagc gcaggacgtc ccgctcgcgg tcggtgagcg
    14641 gcggggtgcc ctggtggagt tcgccgatca ggtgcgccgt accggcgaag tgcggtcaga
    14701 accggatcag gctgttcggt cggccgtcgt accagtgcca ctcctcggtc accgcctcca
    14761 ggaccgtgcc cagccgggcc ttgagcagcg cggtggttcg ggggccgtcg tcgggggtga
    14821 tcaccgctgt ggtgccggcc agtgctcgtg gcagcggtcg acgtgcagtt ccgcagaggg
    14881 gttgcgttgg tgcgcagcgc tcatcttcca ctggcccaac gtgatttccg tgcagcagta
    14941 cgtttcgggg tgtcctacga cctgggccgg gccgtcctcg gccagcccgc gcacgcggtc
    15001 ggcttcgcgc tcgtaggcga gccgactgcc gacaaggaac aacgtgtccg cggcgacggc
    15061 ccagcggagg tggtccttga actcgcggtg gttgtccgtc cggtgctcct cgcgggagaa
    15121 caccgggaag gcgttgggcg ggagcgtcac cgtgtgcgcg gcggatgggg cgagacgggc
    15181 ccgcacctgc ttccaccgcg acaccgggaa ccggaggctg tggtgcagca gcacgaggtc
    15241 gagcttgcgg ccctcgccgc cgtagtcctc gccgcaggtg ggagcacccg accgcaccgg
    15301 caggtagacc aggctgcggg gtgagcgggc ggccggccac caggcgaacg cgaggtccac
    15361 cgtggcggcc ttgtcgaccg ccagccgagg gccgtaccga ccctcgtaca gcgacgcgtg
    15421 gacgaccggg tgctcaggcc ggatcacccg gtagctgtca cggcccaacc gcacggcact
    15481 gaccctcgtc cgccactgcc gtcccgccag ccgcaccccg tcaccccttc gccggtcccg
    15541 ttcggcgaca cggtagacac cgccgccgac cggtgaccag cgaattgcac gccgcacccg
    15601 tccgtcagga cttgtcgtcg tccccggtgt cccccggcca ctcgccggtc accttgtcga
    15661 acagggtcgc cccacctcgg tccacggcgg ccttcaccag gccgaacacc gcgccttgga
    15721 gggtcgccgc gaacagcacc tcgccccagc cccggtcctt gcggttcgcg gccggcggct
    15781 cgtcgtcgcc gctgaccagc ttccacaggt gcccggacag ccggccggcc accagaccgc
    15841 cggccacgcc gagcagcggg cccagcggtt tgtacagcac ccggatcagg ctcatcggcc
    15901 cctcctgacc agccacgtca ccagcagcac cgccgcgatg agcccgccga ccacagccgc
    15961 cggacgtcgg cccgcctgtt cccggaccag cacgaccttc tcctgcacgg gcggcggcag
    16021 cgactccacg gcgtgtgcgg cggcggcggt tgccttgtgc gccaacgagt ccgcggccag
    16081 ttgcgtctcg gcggcggccc gggtcacggc ctgaccggcc cgcgccttcg cctccccggc
    16141 ggcttccttc gccttcgtct tcgcctcccc ggcggcttcc ttcgccttgt cgacgccgtc
    16201 gtgcacgctc tccttgaccc gggcgggcac gtcggccttg tgcgccagcg cttcgaccgt
    16261 gtcgcccagc tcccggcggg tcttctcgat gtccgcgcgc agctgcgcgg tgtcgtcggg
    16321 gatgtccttg ccgctcatcg gtgcgccctc tccgtcacgg tcgaaatgtc ccgcttcacg
    16381 ccttcgatgg cttcctccgg cagcggcggc gtcccttcgg tgacctgctt gcggcccagc
    16441 agcacgagca cgccggccac gaggaagacc agcgcggcca ccacgaaggc cgccgcccag
    16501 gcgggcagca ccagggcgag ggtcagcacc agcccggcga cgaccgtgcc gacgccgaac
    16561 cacgcgagca ccccggcggc acccatcaac ccgacgccga gcccgacgtg cttgcccttc
    16621 tcgctgatct cggccacggc gagccggatc tcctcacgca ccaaccgact cgtctgccga
    16681 gtcacgtcgc gcaccaggtc actggtcgac gtctcggaca cgacctgctc ctctccgtcc
    16741 acgggtccgc agcgcaggtc atcgcggcgg ctgcggcacc acgccgacgg gataccccga
    16801 atgacgcagt tcacccctcc cggtccaccg ggagtccctg acccgtcccg acctgagtcg
    16861 ctccgagccg cgcgcggacc gcgacggcgg cacaggcgat caccgcgaca ccgccgagcg
    16921 cggtcgacca cgtgagctgt tcgcccagca gcagcgcggc ccaacagatc gtcatcacgg
    16981 gttggacgag ctggacttgg ctcacctgcg ccatcggccc gatcgcgaga ccgcggtacc
    17041 aggcgaagaa acccaggaac atgctcacca cggcgaggta gccgaacgcg gcccactcgc
    17101 ccggggtgcc ggtcggcggc tgccggacga ccgcgaagcc cgccaacgcg gccatcagcg
    17161 gcgcggagag caccagcgcc cacgacaccg tctgccacgc cccgagttcg cgggcgagca
    17221 gcccgccctc cgcgtagccg atcccggcgg cgaggaccgc gccgagcagg agcaggtcgg
    17281 accagtgcgg gccgccgatc ccgtcgcccc gcagcgaggc gaacacgacg gcggcggccg
    17341 cccccaccgc cgccatgacc cagaacgacc tcggcgggcg ttcgcgcccg cgcagcaccg
    17401 ctatcacggc ggtgaccgcg ggcagcagcg cgatcacgac ggcgctgtgc cccgccgacg
    17461 cgctggtgag cgcgaacgag gtcagcagcg ggaacccgac gaccactccc ccggcgacca
    17521 ccgcgagccg ggcccactgg ccccctcggg gcaggcgctg ccgggtggcc gccagcgcgc
    17581 cggcggcgag caccgccgcg acgaccgcgc ggccggagcc gacgaacagc ggcgacatcc
    17641 cgccgccgac gacgacccgg gtgaacggca cggtgaacga gaacgccgcg accccgacca
    17701 ggccccatcc cagacccgcc cgggacggcg atagcacggc cgcccggctg agcgtagcgc
    17761 tactattgcc actcatgtcg gacgatagca gtgcacggat cgcggccggc gtgcgcgact
    17821 gggtcgcggc cgccgcgccg ggtgcgaagc tgccctccac gcgcgccctg gtcgcgcggt
    17881 acgcggcgag cccggtcacc gtgcagaagg cgctgcggac cctggccgcc caaggtctga
    17941 tcgaaagccg gcctggcgtg ggaactttcg tgcgcgcggt gcgcacgacc cgcccgaacg
    18001 actacggctg gcagaccgcg gcgctcggct cgcccggctt ccgggccacc caacgctcca
    18061 cggcgctgcg gaccaccccg aacgacgtga tcgcgttgca ctccggctac ccggaccggg
    18121 aactgctacc cgaacggctc gtccgggccg cgttcacccg ggccgcgcgc ggtgacgccg
    18181 ccgtcacccg accgccgacc gcgggactcc cggagttgca ggcgtggttc gccaccgagc
    18241 tgggcgcgtt cggcggtgct cccccgtcac ccggcgaggt cgtcgtcttc cccggcagcc
    18301 agagcgcgct gtgcaccgtc ttccgcgccc tcgtcggccc ggagcgcccc ctgctggtgg
    18361 agtccccgac ctactggggc gcgctgctgg ccgccgcgca gtcgggcgtg cgggtcgtgc
    18421 ccgtgccgag cagtgcgcac gggcccgacc cggacgagct ggcccgcgcg ttctcccgga
    18481 ccggggcgcg ggcgttctac gcccagccga acttcgccaa ccccaccggg gcgcagtggt
    18541 cgcccgacct ggccgagaag gtgctcgacg tcgtgcgccg gcacggggcc ttcctggtcg
    18601 aggacgactg ggcgcacgac ttcggcatca ccgccgaccc ggtcccgctc gccgcccgcg
    18661 acgacggcgg gcacgtcgtc tacctgcgct cgttgaccaa gagcgtctcg ccggcggtgc
    18721 gggtggccgg gatcgtcgcc cgcggcccgg cccgggagcg gatcctggcc gacgtcgagg
    18781 cggtgtccat gtacgtcagc ggcgtgctcc aggcggtggc gctggacgtg gtcacccagc
    18841 ccgcctggcg gacccaccgg cgcgactcgc gccaccggct cgccgcccgc cgtgacctga
    18901 tggtcgcggc cctgcacgag cacgtcccgg ccgcccggct ggaggccgtg ccgcacggcg
    18961 ggctcaacct ctgggtgcgc ctgcccgacg gcaccgacct ggcccggctg gtccgcgact
    19021 gcgacgccgc cggcgtggtg gtcgcacccg gcaacgagtg gttcccggcc gaaccgaccg
    19081 gcgcctacct gcggctcaac tactccggcc cgaaccccgg cgccttcccc gacggcgtcc
    19141 gtaccgtcgg gagtgcgctg gcccggcaga cctgaccaca gccgtcggtg ctgacagctg
    19201 ctcaggaagg agtcggccgg caaacgcacc cgcctgatcc acccaggcgc gtgctccgcg
    19261 cacgtcgtcg ctgccggcgg cctcccccgg gtcgccggca gcgcagggcg gtcacgatga
    19321 cggagccgcc cgccgtcccg gttcgtcggg ctacccggcc cggtgcgcga cccggcccgc
    19381 gaccacggtc agctcgaccg gcaggtccgc cagttcctcg gccggcacgg tcagcgggtc
    19441 gccgcggaac accgtgaggt cggcgcggaa accctcccgg atccgcccgg cgacctgttc
    19501 ctcaccgctg ccgtaggcgg cccacgtggt gtagccggcc aggctctggc gcgcggtgag
    19561 cgcctggtcc gcgccgaccg gcgcacgacc gtgctcggcg gcggggcggc gcagccgggc
    19621 cccggccatc accacccggg ggtcgtagcc ggcgaccggc cagtccgagc ccagcgcgac
    19681 gcggccgccc gcgcgcacga tgtcggcgca ccgccagccg tgcccgcagc ggtccgggcc
    19741 cagccgctcg gaccagttgt cggtgtggtc gggcagcgtc cagtccaggt gcgtgggctg
    19801 catcgaggcg acgacgtcga ggccggcgaa ccgggtgacg tcgtcgtcgg cgagcagttc
    19861 ggcgtgctcg acgcggtgcc ggccgcgcgc cgggcggccg acggcctggt aggtgtccag
    19921 ggcctcggtc accgcgcggt cgccgatggc gtgggtgaag ctgggcaggc cgagcgcggc
    19981 ggcccggcgc accgcgtccc ggtaccggcc caggtccgtc cacatcggac gggtgccgtc
    20041 gccggcgcag tccgggtgcc ccagccaggc cgagccgccg tcgatggtgc cgtcgaggaa
    20101 gaacttgacc gcacccgtcc gccacagctt ggcgcggtcg tcggcccgtg cgccgcgcag
    20161 ggcgtcgagg gtctcctcga tccgggccgg gaacatccac ggggcgcgca gcacccgcag
    20221 cggcagccgg ccctgcgcct ccagcgcgtc gaggacggcc tcggtgccgg cccacgagtc
    20281 ggggacgtgg atcgcggtga tgccgcaggc ggcctggtcg gcgaacaggt cggcggccag
    20341 tcgggcgatg tgctcggtgg acgggctcgg gacggccgcg tagccgtgca gcacggcgga
    20401 catctcgtgc agctgcccgg tgggcacgcc gtcctcgtcc accacgatct cggagcggtc
    20461 gccgaagtcg atcggccccg tgatgccggc caggtgcaac gcccgcgtgc tcatcagggc
    20521 ggtgtgggag tcggcgagcc acaggaacgc gggccggccc gccaccgcgt cgtccaggaa
    20581 ctgccggggc cggtcgggca gcgccgggta ctcgacgccg ttcacgacca cccagccgtc
    20641 cggcggcagc ccgtcggcgg cgcggcgcag caggtcgcgc agtcgcaccg gggtggtgag
    20701 cccggccgcg tccacgcccc cggcgtcggc gacgccgtgc agcgggtgct ggtgcgagtc
    20761 gaccaggccc ggcgtgacga ccagaccgga cccgtcgacc acctcggtgc gcgagccgat
    20821 cggcaggtcg tcgccgacgg ccacgaccag cccgtcgcgg acggcgaccg cactggcgag
    20881 gggccgctgc gggtccatcg tgtggacggt ggccccgagg atcaccaaat cggcggcggt
    20941 catcggtcga ttccttccac gcgggtcgcg aacgaggcgc tgaccagcac tttatcctgg
    21001 ggacgggcga tcagcaggta cagcaggccg gccagcacga ccaccgccga caccagcggg
    21061 gccgcccaga tctggtacca gggcgcgccg accggggcga ggatggcccg gggccacgcg
    21121 atgttgacga actcgaagcc cagccacccc accgccaggg cgttgatcac ggtgccggtc
    21181 cggcccagcc gcacgtaccc ggccggcacc cacgtgccgc gcagccgggc gatcagcgcc
    21241 gccagcgcgg tcaggaagaa cgtcaggtag agcaccgccg tgccgaacgc gatcaggctg
    21301 ccgatggccg cgctgttcac cgccagcagc agcccggcgc agcccacgac cgtcaccgcc
    21361 acgaccgcgc cgatgggcac ctgccggcgg ctgaccgcgg acatcagccg cgacagcggc
    21421 agcacgccgt cgcgggccat cgagtagacg ccccgggccg tcgagccctg cgaggccagt
    21481 ccgcaggcga agaacgcgac caccacgacg accacgaacg gcttggccga ccagctcccg
    21541 aacgaggcga tcaccgccgt cgacaccggg tccgggtcga ggccggcgac caccgagggc
    21601 aggtccgggt ggaccagcgt ggtggcgaac gcgttcagga tcaccagcgc gccgacgctg
    21661 agcagcgccc accagatcgc ccgcggcacg tgccgggcgg cgttgcgggt ctcctcggag
    21721 gtggcgacgc aggcgtcgaa cccgatgaac gcccacccgc cgacggccag cgcggcgagc
    21781 agcgcggccg gcaccgagcc ggccgagccg gcctccgcgc ccagggtggc ggtcaggatc
    21841 gagaacggct gctcgcggaa cgccagcagc agcaccaccc cgatcagcac cgacgcgacg
    21901 gcctcggcgg cgacgccgag cgcgagcacg cggcgcagca cgtcgatgcc gaacgtgttg
    21961 accagcgcgc acaccacgat gaacccggcg gccacggcca ccagcaggtt gggcgtgggg
    22021 gtgatgccga acagccccag gatccacggc gcggacaggt agccgatggt ggtgttggcg
    22081 accagcggcc cgcacagcga cagccacccg gtcatccagg cgaacccggg cccgatcagc
    22141 cggcgggacc actggtaggc cccgccggag accgggaact ccgaggcgag ttcggagtag
    22201 acggtcagca gcaggcactg gccgagcagg cagaccggca gcgcccacac ccaggcgggg
    22261 ccggccaccg tcatgccgac cagcaccacc gcgtagagcc cgaccaccgg cgagacggtc
    22321 gcgaagccca tcccgatgtt gcccagcacg cccagccgcc ggctcaaccg ctgctcgtag
    22381 cccagcgccc ggagccgggc gtcgtcggcc gcggtctccg ggttggccgc cggcggcggg
    22441 gcggttctgc tggtcgggtc ttcgatcacg gcggggcctc ctgcggtgtc ctggagcgga
    22501 ctgagacgct gatcacgtgg agtgggacgg taggtgggcg ggaccgggcc cgtcgatgga
    22561 cgtggcggtg aacttcccgc gcagggtgga cactgtgtcc atgccgctca ccgtgaacgc
    22621 cctgctggcc gtgcgcgacc tgcacctggc gctggtcgcc ggcgcgaccg ggcgggaccg
    22681 ggtgatcgag gccgcgcacg tctcggagct ggcccggccc ggcgagtggc tgcacggcgg
    22741 tgaactgctg atgacggccg gtgtggtgct gccgaccgac ccggagtcgt gccgggggta
    22801 cgtgcgggac gtggtggacg gcggcgcggc ggcgctcggg ttcggcgtcg gccacggcca
    22861 gccccacctc gcgccgcccg cgcgctggtg gccgccgccg aggaggccgg gctgccgctg
    22921 ctggtggtgc cggacgaggt gccgttcatc gcggtgacca aggcggtgtt cgcggcgctc
    22981 gcggccgagg accggcgcgc gttggagcac accgtcgacg tgcagcgccg gctcaccgtc
    23041 gccgcgacct ccggcggcct cgacgcgatc ctcaaggtgt ggctggacgc gaccggccgc
    23101 gccgccgtgg tgaccgacct gctcggccgg gagctggccg gcgtcggccc cgccgcccgc
    23161 ccgctgctcg ccgccgggcg caccgtgctg gacgaggtgg gcgcgcgcgg cctgctgggc
    23221 agcgcgtccg tggcggtgga cgggctgacc gtgggcgtgc agccgatcgg cgcccgccgg
    23281 ctgcgcgggc acctgctgct ggcccgcccg ccgcagccca cgcccggcac cgcggacgcc
    23341 gcgctggtgt cgctgctgac gctggagctg gaacgccgcc acctggccga cgagccgcgc
    23401 cggcgggccg gtgcggaggc gacggcccgg ctgctcgccg ggatgcccga cgaccaggcc
    23461 gccgcgaccc tcgccgcgtt cggcctgtcc gcgccctcgg tgcgcggcct cgccgtgcgg
    23521 gcccggcccg acgacaccgc ggaactcgcg gccgacctgg cgctcgtgct gcccggcggt
    23581 ctggtccggt cctccggcga cacggtcgag gcgctggtgg tggacgaggt cgacgtcccg
    23641 gcgctgctcg accggttcgc gcccggacgc ccggc
//
