LOCUS       NC_019673              21110 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Saccharothrix espanaensis DSM 44229, complete sequence.
ACCESSION   NC_019673
VERSION     NC_019673.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Saccharothrix espanaensis DSM 44229
  ORGANISM  Saccharothrix espanaensis DSM 44229
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Saccharothrix.
REFERENCE   1
  AUTHORS   Strobel,T., Al-Dilaimi,A., Blom,J., Gessner,A., Kalinowski,J.,
            Luzhetska,M., Puhler,A., Szczepanowski,R., Bechthold,A. and
            Ruckert,C.
  TITLE     Complete genome sequence of Saccharothrix espanaensis DSM 44229(T)
            and comparison to the other completely sequenced Pseudonocardiaceae
  JOURNAL   BMC Genomics 13, 465 (2012)
   PUBMED   22958348
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9360653)
  AUTHORS   Rueckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2012) IGS, CeBiTec, Bielefeld University,
            Universitaetsstr. 27, D-33335, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000328705.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:06:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,451
            Genes (coding)                    :: 8,313
            CDSs (with protein)               :: 8,313
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 43 of 138
            Pseudo Genes (incomplete)         :: 116 of 138
            Pseudo Genes (internal stop)      :: 7 of 138
            Pseudo Genes (multiple problems)  :: 27 of 138
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:45:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2219932
            Orig. end                         :: 2241042
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE804045.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21110
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="furan"
                     /region_number="6"
                     /rules="(mmyO or AvrD)"
                     /tool="antismash"
     cand_cluster    1..21110
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(mmyO or AvrD)"
                     /kind="single"
                     /product="furan"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21110
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11110](-)"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11110)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
     gene            complement(22..1134)
                     /locus_tag="BN6_RS10350"
                     /old_locus_tag="BN6_21210"
     CDS             complement(22..1134)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099555.1"
                     /locus_tag="BN6_RS10350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21210"
                     /product="3-oxoacyl-ACP synthase III family protein"
                     /protein_id="WP_015099555.1"
                     /sec_met_domain="fabH (E-value: 7.9e-79, bitscore: 264.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHLRERTRPRGVGIRSIGRYLPDRVVSNADLERILLTRDDWIRE
                     NIGVRTRRMAADDQWTSDLGAAALLDACARAGVRPSEVDLVVCGTYTPDHMAPPTAMLV
                     IDKSGAVGAAGFDVNSGACPGGVFALDVGAKYLASGQYRRVAVVLADVSTRTMDWKDPG
                     PAVIFGDGAACYLLEPCTPGLGIGTTLLRSDPSAYQAVRVARERRTRRDGTRLSSGFGD
                     NFSTLDGNAVHGLAVGEVPPFVEELLAAAGREVEDIDLFALHQANLYIVREIMAAIGVP
                     MDRTVVNIEKYGNTSGASVPLVLREAEDTGRLSPGDQVVLAAFGSGFSMGAALVRWCGP
                     EDFAPEEFAPEEFAPEKLAPEQFASTGIRS"
     gene            complement(1181..2053)
                     /locus_tag="BN6_RS43480"
                     /old_locus_tag="BN6_21220"
     CDS             complement(1181..2053)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012995.5"
                     /locus_tag="BN6_RS43480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21220"
                     /product="arylamine N-acetyltransferase"
                     /protein_id="WP_051075499.1"
                     /transl_table=11
                     /translation="MEHVASPSRTATTAALPWHDYLRRIGHTGPLEPTAEYLRAVTTAH
                     LHAVPYEFLDVLDGAVPDLEHTAAFDRVVRRRRGGTCLETTPLLGRFLRGVGFRARLVA
                     AQMWRVGGEWWSRWDHLVLVVEAEGEDWLVDVGFLLHSPTEPLRLSGTPQADGGWRFRV
                     VERDGYRTVLRSGVDDEWTPVYRFADEPLEIPDYAWIVDFHLTSEESPLSYTVLCSRVV
                     PGGKLVVLGENFLRSLDGRDRTEFLADPADAEKALGEVLHGHPHLLAEAVGAWEKARAD
                     RRENKRKFI"
     gene            2280..2723
                     /locus_tag="BN6_RS45500"
                     /old_locus_tag="BN6_21230"
     CDS             2280..2723
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0016790 - thiolester hydrolase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099557.1"
                     /locus_tag="BN6_RS45500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21230"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_015099557.1"
                     /transl_table=11
                     /translation="MDSNAVADGGPEPTARWGRALPPHLVDRQLAVRMGIEIVSWDPDR
                     MVGTMPVEGNQQPLGWLHGGANAVLAETLGSLAAGVHVASRGAVAGLELSCTHHRSVRR
                     GVVTGVCTPLLLGDRVVTYQVSISDDRGRLTCTARLTCLVGKR"
     gene            2740..3273
                     /locus_tag="BN6_RS10365"
                     /old_locus_tag="BN6_21240"
     CDS             2740..3273
                     /EC_number="1.5.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.5"
                     /locus_tag="BN6_RS10365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21240"
                     /product="flavin reductase family protein"
                     /protein_id="WP_015099558.1"
                     /transl_table=11
                     /translation="MSTPAVRLPGGRSADPGEFRKVMGLFPTGVTVVTAGRGERTEAVT
                     ASAVASISLDPPLVLVSLRAAGRLPTAIDGAGGFAVNVLAADQERLSALFAARDRPRGV
                     AALERLGGTVGASGHVVLPSAVLSLECRTEHRYPGGDHVLFLGRVLAVHAAEPVKAPLV
                     HHRGAYHRLHHLSD"
     gene            3289..3993
                     /gene="fabG"
                     /locus_tag="BN6_RS10370"
                     /old_locus_tag="BN6_21250"
     CDS             3289..3993
                     /EC_number="1.1.1.100"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (3-166). E-value: 1.2e-20. Score:
                     66.1. Matches aSDomain:
                     nrpspksdomains_BN6_RS10370_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226771.1"
                     /locus_tag="BN6_RS10370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21250"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_015099559.1"
                     /sec_met_domain="adh_short (E-value: 3.9e-35, bitscore:
                     120.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 3.3e-30, bitscore:
                     104.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARSVLVTGGNRGIGLAVARKFAAHGDAVAVTHRGSGAPEGLLGV
                     KCDVTDTDQVSRAFAEVAAVNGPVEVLVANAGITRDGLLMRMDDDQFLGVLDTNLGGAF
                     RVARHAATDMVRRRGGRMVFLSSVAGLRGSPGQANYASSKAGLVGLARSLAREFGSRGI
                     TVNVVAPGLVDTDMTEQLSAQRKEQILADVPLGRSAAPEEVADAVFWLASPGAAYVTGA
                     VLPVDGGLGMGH"
     CDS_motif       3298..3369
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10370_0001"
                     /evalue="8.80E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN6_RS10370"
                     /protein_end="27"
                     /protein_start="3"
                     /score="24.8"
                     /tool="antismash"
                     /translation="SVLVTGGNRGIGLAVARKFAAHGD"
     aSDomain        3298..3786
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10370_PKS_KR.1"
                     /evalue="1.20E-20"
                     /label="BN6_RS10370_PKS_KR.1"
                     /locus_tag="BN6_RS10370"
                     /protein_end="166"
                     /protein_start="3"
                     /score="66.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="SVLVTGGNRGIGLAVARKFAAHGDAVAVTHRGSGAPEGLLGVKCD
                     VTDTDQVSRAFAEVAAVNGPVEVLVANAGITRDGLLMRMDDDQFLGVLDTNLGGAFRVA
                     RHAATDMVRRRGGRMVFLSSVAGLRGSPGQANYASSKAGLVGLARSLAREFGSRGITVN
                     "
     CDS_motif       3607..3666
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10370_0002"
                     /evalue="1.30E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN6_RS10370"
                     /protein_end="126"
                     /protein_start="106"
                     /score="1.8"
                     /tool="antismash"
                     /translation="ARHAATDMVRRRGGRMVFLS"
     CDS_motif       3652..3714
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10370_0003"
                     /evalue="1.60E-09"
                     /label="PKSI-KR_m4"
                     /locus_tag="BN6_RS10370"
                     /protein_end="142"
                     /protein_start="121"
                     /score="30.3"
                     /tool="antismash"
                     /translation="MVFLSSVAGLRGSPGQANYAS"
     CDS_motif       3916..3981
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10370_0004"
                     /evalue="1.60E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="BN6_RS10370"
                     /protein_end="231"
                     /protein_start="209"
                     /score="-1.6"
                     /tool="antismash"
                     /translation="WLASPGAAYVTGAVLPVDGGLG"
     gene            complement(4143..4565)
                     /locus_tag="BN6_RS10375"
                     /old_locus_tag="BN6_21260"
     CDS             complement(4143..4565)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099560.1"
                     /locus_tag="BN6_RS10375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21260"
                     /product="MaoC/PaaZ C-terminal domain-containing protein"
                     /protein_id="WP_015099560.1"
                     /transl_table=11
                     /translation="MSAFSLADVEVGTELPELPELRITRALLVRFADASGDPNPIHLDP
                     DAARAAGLSDVIAHGMLSMGFLGRLVTEWVPVADLLSFRVRFAAATPVGARIRCAAKVK
                     DLAEHDGERRVRLSLTVRVVDGPVTVRGDALVRVAR"
     gene            complement(4562..5077)
                     /locus_tag="BN6_RS48535"
                     /old_locus_tag="BN6_21270"
     CDS             complement(4562..5077)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672096.1"
                     /locus_tag="BN6_RS48535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21270"
                     /product="MaoC family dehydratase N-terminal
                     domain-containing protein"
                     /protein_id="WP_051075501.1"
                     /transl_table=11
                     /translation="MGSARLGSTSVDGGPTRERGQEIDRAFIGTRLAPFTVEVDRSEVA
                     SFAEVLGVGGGVFADLGVARAAKHPDLPVPPTFLFGLEFRNPSDVLTAMGVELRRVLHV
                     EQGFVYHRTAYAGERLTFSTVITDIYGRGGMEFVVQDTAVTDTDGEPVADHHQIIAVRL
                     SASVGEDR"
     gene            5382..6962
                     /locus_tag="BN6_RS10385"
                     /old_locus_tag="BN6_21280"
     CDS             5382..6962
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (23-424). E-value: 9.9e-78.
                     Score: 253.4. Matches aSDomain:
                     nrpspksdomains_BN6_RS10385_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099562.1"
                     /locus_tag="BN6_RS10385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21280"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_015099562.1"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-79, bitscore:
                     266.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVPDEWWAGHGGYAARVLSALVADPDRVALHWRGRGVTAREVTD
                     AVAGIADTLRRLDIGQGDVVGVMVAPNSPDMLTARYAAHLVGAAVCYVRSTNPGSADPV
                     LSEEEQLRILLDTRARGLFTDTGNEDRAKRLVDRARGLVALVGFDLDPAGATAVASADR
                     ANLAPAAAWDPAALAVIGFTSGSTGRAKGISLQARAWESTVVATEESITEPDPAILVTT
                     PLSHTVAPMADAVLARGGVVVLHEETRPGPVLDALRQHRITRTFVATPHLYELLDHSRT
                     APADLSSLRLLIYSGSPAAPARIAEAARAFGPVLVQGYGTSECGRITFLGPGDHFDETV
                     LSSVGHPFPEIEVEVREPGSDRAVAVGETGEVCVRSPHVMREYWADPARTSRVLRDGWY
                     RTGDIGRLDERGYLYLLDRIADVVKADGVKVYPAVVEREIQSIPGVAHAAVYGVRDEDN
                     AEHVHAAIVLRPGARVGVDEVRERVRTALSAAHAPEHVRLLDALPLNGSGKPDKARLRG
                     EELAARVPR"
     aSDomain        5451..6653
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10385_AMP-binding.1"
                     /evalue="9.90E-78"
                     /label="BN6_RS10385_AMP-binding.1"
                     /locus_tag="BN6_RS10385"
                     /protein_end="424"
                     /protein_start="23"
                     /score="253.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ADPDRVALHWRGRGVTAREVTDAVAGIADTLRRLDIGQGDVVGVM
                     VAPNSPDMLTARYAAHLVGAAVCYVRSTNPGSADPVLSEEEQLRILLDTRARGLFTDTG
                     NEDRAKRLVDRARGLVALVGFDLDPAGATAVASADRANLAPAAAWDPAALAVIGFTSGS
                     TGRAKGISLQARAWESTVVATEESITEPDPAILVTTPLSHTVAPMADAVLARGGVVVLH
                     EETRPGPVLDALRQHRITRTFVATPHLYELLDHSRTAPADLSSLRLLIYSGSPAAPARI
                     AEAARAFGPVLVQGYGTSECGRITFLGPGDHFDETVLSSVGHPFPEIEVEVREPGSDRA
                     VAVGETGEVCVRSPHVMREYWADPARTSRVLRDGWYRTGDIGRLDERGYLYLLDRIADV
                     VK"
     CDS_motif       5913..5966
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10385_0001"
                     /evalue="5.60E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="BN6_RS10385"
                     /protein_end="195"
                     /protein_start="177"
                     /score="16.0"
                     /tool="antismash"
                     /translation="AVIGFTSGSTGRAKGISL"
     CDS_motif       6477..6554
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10385_0002"
                     /evalue="2.20E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="BN6_RS10385"
                     /protein_end="391"
                     /protein_start="365"
                     /score="23.3"
                     /tool="antismash"
                     /translation="VGETGEVCVRSPHVMREYWADPARTS"
     gene            7006..8232
                     /gene="hemA"
                     /locus_tag="BN6_RS10390"
                     /old_locus_tag="BN6_21290"
     CDS             7006..8232
                     /EC_number="2.3.1.37"
                     /GO_function="GO:0003870 - 5-aminolevulinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0033014 - tetrapyrrole biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (50-392). E-value:
                     6.9e-75. Score: 244.3. Matches aSDomain:
                     nrpspksdomains_BN6_RS10390_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="hemA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109: 8-amino-7-oxononanoate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099563.1"
                     /locus_tag="BN6_RS10390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21290"
                     /product="5-aminolevulinate synthase"
                     /protein_id="WP_015099563.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 8.9e-73, bitscore:
                     244.5, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNRHMDFFVREMADFGPRKREFLEIGRRAGLFPSAVARQGPDGT
                     EAEISVWCSNDYLGMGQNPFVLEAIKDAVDAFGAGSGGSRNIGGTNHYHVLLEKELAAL
                     HGKEAALIFPSGYTANDGALSVLAGRAPDTVVFSDQLNHASIIDGLRHSGAEKRIFRHN
                     DVAHLEELLATADPDRPKLVVAESVYSMSGDIAPLAQIAEVSHRYHATTFLDEVHAVGM
                     YGPQGAGIAAREGLADRFTVFMGTLAKGFGTAGGYIAGPAALVDAVRSWSRSFIFTTSL
                     PPATAAGALAAVRHLRSSEVERERLAANARLMHRLLTERRIPFISDQSHIIAVFVGEDQ
                     LCRQASALLLRRHGIYVQAINAPSVRTGEEILRVAPSATHTAGDVEKFVEALDGIWQEL
                     GIPTGPTAG"
     aSDomain        7156..8181
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10390_Aminotran_1_2.1"
                     /evalue="6.90E-75"
                     /label="BN6_RS10390_Aminotran_1_2.1"
                     /locus_tag="BN6_RS10390"
                     /protein_end="392"
                     /protein_start="50"
                     /score="244.3"
                     /tool="antismash"
                     /translation="VWCSNDYLGMGQNPFVLEAIKDAVDAFGAGSGGSRNIGGTNHYHV
                     LLEKELAALHGKEAALIFPSGYTANDGALSVLAGRAPDTVVFSDQLNHASIIDGLRHSG
                     AEKRIFRHNDVAHLEELLATADPDRPKLVVAESVYSMSGDIAPLAQIAEVSHRYHATTF
                     LDEVHAVGMYGPQGAGIAAREGLADRFTVFMGTLAKGFGTAGGYIAGPAALVDAVRSWS
                     RSFIFTTSLPPATAAGALAAVRHLRSSEVERERLAANARLMHRLLTERRIPFISDQSHI
                     IAVFVGEDQLCRQASALLLRRHGIYVQAINAPSVRTGEEILRVAPSATHTAGDVEKFVE
                     AL"
     gene            8369..9895
                     /locus_tag="BN6_RS10395"
                     /old_locus_tag="BN6_21300"
     CDS             8369..9895
                     /NRPS_PKS="Domain: AMP-binding (9-407). E-value: 1.9e-116.
                     Score: 381.0. Matches aSDomain:
                     nrpspksdomains_BN6_RS10395_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099564.1"
                     /locus_tag="BN6_RS10395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21300"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_015099564.1"
                     /sec_met_domain="AMP-binding (E-value: 4.6e-122, bitscore:
                     406.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVSLAAVLAESAARYPDRPAVVFESRKTSYRELWWWARKYAAVL
                     RDHGIGRGDRVALLLPNSPHLPMAYFGVLALGAVVVPVHALSKADEIEHVLRDSGAAAL
                     VCAGSLLEQGGEAARRAGVPVFTVVADDGLRLDVAAGPAAPIERYAPCAPDDAAMVLYT
                     SGTTGKPKGAVLTHLGVTMNITVTMLSPFDFRADDVLLGALPLFHIFGQVCGMCVCFRA
                     GATLVLMPAFDAARAIELMAEHRCTVFMGVPTMYMALLRAMGTATVRPRLHRAYSGGQA
                     LPVKVLEDFEDRFGCPVYEGYGLTETSPVVAYNQPAWPRKPGTVGLPVWGVEVAIARAD
                     VDGRVELLPAGEVGEVVIRGHNVMAGYLNRPEATAEVLVDGWFRSGDLGRKDEDGYLSI
                     VDRKKDVVLRGGYNVYPREVEEVLMRHPAVAQVAVIGVPHPTHGEEVCAVVLPAPGARP
                     GADLGVEIETWSKARMAPYKYPRRVEFVDGFPLGVGGKVLKRELVARFAR"
     aSDomain        8396..9589
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10395_AMP-binding.1"
                     /evalue="1.90E-116"
                     /label="BN6_RS10395_AMP-binding.1"
                     /locus_tag="BN6_RS10395"
                     /protein_end="407"
                     /protein_start="9"
                     /score="381.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AESAARYPDRPAVVFESRKTSYRELWWWARKYAAVLRDHGIGRGD
                     RVALLLPNSPHLPMAYFGVLALGAVVVPVHALSKADEIEHVLRDSGAAALVCAGSLLEQ
                     GGEAARRAGVPVFTVVADDGLRLDVAAGPAAPIERYAPCAPDDAAMVLYTSGTTGKPKG
                     AVLTHLGVTMNITVTMLSPFDFRADDVLLGALPLFHIFGQVCGMCVCFRAGATLVLMPA
                     FDAARAIELMAEHRCTVFMGVPTMYMALLRAMGTATVRPRLHRAYSGGQALPVKVLEDF
                     EDRFGCPVYEGYGLTETSPVVAYNQPAWPRKPGTVGLPVWGVEVAIARADVDGRVELLP
                     AGEVGEVVIRGHNVMAGYLNRPEATAEVLVDGWFRSGDLGRKDEDGYLSIVDRKKDVV"
     CDS_motif       8840..8899
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10395_0001"
                     /evalue="8.10E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="BN6_RS10395"
                     /protein_end="177"
                     /protein_start="157"
                     /score="27.6"
                     /tool="antismash"
                     /translation="AMVLYTSGTTGKPKGAVLTH"
     CDS_motif       9413..9499
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10395_0002"
                     /evalue="1.90E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="BN6_RS10395"
                     /protein_end="377"
                     /protein_start="348"
                     /score="36.2"
                     /tool="antismash"
                     /translation="PAGEVGEVVIRGHNVMAGYLNRPEATAEV"
     gene            complement(10001..11110)
                     /locus_tag="BN6_RS10400"
                     /old_locus_tag="BN6_21310"
     CDS             complement(10001..11110)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /function="Acts on both enantiomers of limonene by their
                     NAD- dependent epoxidation at the 1,2 double bond forming
                     limonene-1,2- epoxide"
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     mmyO"
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099565.1"
                     /locus_tag="BN6_RS10400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21310"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_015099565.1"
                     /sec_met_domain="mmyO (E-value: 7.4e-203, bitscore: 672.4,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRIGFGAFLSPLHPLGEDPSLSLWRDLELAEWLDQLGYDELWVG
                     EHHSAGWGTISSPELFIATAAERTRHIRLGTGVVSLPYHHPFMVASRAVQLDQLTRGRF
                     TLGVGAGSIPTDMHLLGIDPADTRRRTAEALDVIHKLLHDTVPVTVRTDWFEVRDARLQ
                     LRPHSPAGLPMAVSSAVSPFGMRLAGQYGISPISFGIPPRPGSRIGDLVGQWQHAEAAA
                     AEHGRKLDRGDWRVALSVHVSDSREQALDEIVDGWMRYRNEYWALLGAPRVHSRAEARK
                     ALEELIDRRGSVIGSVDDCVQAIRDVQDETGGFGRLLVTVLDWADRSALKRSFELLARF
                     VAPKFNGSLGGVTESYGRAVSKALELAAR"
     gene            complement(11121..11834)
                     /locus_tag="BN6_RS41750"
                     /old_locus_tag="BN6_21320"
     CDS             complement(11121..11834)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ketoacyl-synt_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099566.1"
                     /locus_tag="BN6_RS41750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21320"
                     /product="beta-ketoacyl synthase chain length factor"
                     /protein_id="WP_015099566.1"
                     /sec_met_domain="Ketoacyl-synt_2 (E-value: 5.4e-06,
                     bitscore: 25.1, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSDLPRAVVGAACLAPWGERARDVPGAAPVDLTSVPGFVTSRF
                     NPLVAAVAEQCLGAPGGDLIHGLGERTAIVLATACGDTTTSDLATRKLVAGQVHSPLLF
                     FQSVTTSILGHLARQYGITGPVSCVSACEDLAGSALRLADLLLFDDELEQVLVIGVELA
                     PNDRVTWVRDRLGAEHPLGRLPLGEDAAVALLLRRATRGRPAVPADPPHPAYGWLGQLV
                     GLCTAAAHPDTSTTD"
     gene            complement(11867..13060)
                     /locus_tag="BN6_RS10410"
                     /old_locus_tag="BN6_21330"
     CDS             complement(11867..13060)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (137-368). E-value:
                     2.2e-42. Score: 137.3. Matches aSDomain:
                     nrpspksdomains_BN6_RS10410_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099567.1"
                     /locus_tag="BN6_RS10410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21330"
                     /product="beta-ketoacyl synthase"
                     /protein_id="WP_015099567.1"
                     /sec_met_domain="t2fas (E-value: 1.7e-86, bitscore: 289.5,
                     seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.3e-24, bitscore:
                     86.1, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSREVVITGYGVLTAFGFGPEALLDNVFTGRPGFAPVTRFDSTPY
                     HAAHAATYEGDGPEMPGVPVKPGYTPTQAEVLHACAAEALRMSGTDAAGAPVLLGTNGD
                     HSAARSFWTDHAEGRDPGNPRTVDSLPGHLPESMGAAFGLGTPRLAFVNACVASTNAIG
                     HGAELVRRGLADAVVCGGAYLVTEDVFAKFDSGKALSRSGAVRPFAADRDGLLHGDGAA
                     VLVLESAERARARGAEPLAEVAGWGMSSDAHHVIKPHPKGKGLVRAARAALRSAEVDVG
                     QLGYVNAHGTGTPLNDVAETAGLRRILGAHAPAVPISSTKGSTGHMLEATGAVEAVITL
                     LALREGLLPPTASLRVPDPECDLDYLPDVGRRAPITHALSLNAAFGGVNAALVLKRV"
     aSDomain        complement(11957..12649)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10410_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.20E-42"
                     /label="BN6_RS10410_PKS_KS.1"
                     /locus_tag="BN6_RS10410"
                     /protein_end="368"
                     /protein_start="137"
                     /score="137.3"
                     /tool="antismash"
                     /translation="MGAAFGLGTPRLAFVNACVASTNAIGHGAELVRRGLADAVVCGGA
                     YLVTEDVFAKFDSGKALSRSGAVRPFAADRDGLLHGDGAAVLVLESAERARARGAEPLA
                     EVAGWGMSSDAHHVIKPHPKGKGLVRAARAALRSAEVDVGQLGYVNAHGTGTPLNDVAE
                     TAGLRRILGAHAPAVPISSTKGSTGHMLEATGAVEAVITLLALREGLLPPTASLRVPDP
                     ECDLDYLPD"
     CDS_motif       complement(12161..12208)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10410_0001"
                     /evalue="6.80E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="BN6_RS10410"
                     /protein_end="300"
                     /protein_start="284"
                     /score="9.3"
                     /tool="antismash"
                     /translation="YVNAHGTGTPLNDVAE"
     gene            complement(13050..13307)
                     /locus_tag="BN6_RS10415"
                     /old_locus_tag="BN6_21340"
     CDS             complement(13050..13307)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS10415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_21340"
                     /product="hypothetical protein"
                     /protein_id="WP_015099568.1"
                     /sec_met_domain="PP-binding (E-value: 0.00025, bitscore:
                     20.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITESDVARLLRESGLPLAEWDSSTELVLDSLTSVWLLHHLEEQY
                     GIVVGPEDEDEVAASDSIGSLHLVLRRVQAGALEGARHVP"
     gene            complement(13304..13582)
                     /locus_tag="BN6_RS10420"
                     /old_locus_tag="BN6_21350"
     CDS             complement(13304..13582)
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (7-77). E-value: 1.8e-10.
                     Score: 33.0. Matches aSDomain:
                     nrpspksdomains_BN6_RS10420_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099569.1"
                     /locus_tag="BN6_RS10420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21350"
                     /product="acyl carrier protein"
                     /protein_id="WP_015099569.1"
                     /sec_met_domain="PP-binding (E-value: 3.7e-09, bitscore:
                     35.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAETREFILTVIRDVINIPLPDRVEDDLPLGEEGLGLESLAMIE
                     LVLQLEGAYGVELQEDELTADLVPDLGALVDTVVGLRSAAAAGSVAR"
     aSDomain        complement(13352..13561)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10420_PP-binding.1"
                     /evalue="1.80E-10"
                     /label="BN6_RS10420_PP-binding.1"
                     /locus_tag="BN6_RS10420"
                     /protein_end="77"
                     /protein_start="7"
                     /score="33.0"
                     /tool="antismash"
                     /translation="FILTVIRDVINIPLPDRVEDDLPLGEEGLGLESLAMIELVLQLEG
                     AYGVELQEDELTADLVPDLGALVDT"
     gene            complement(13622..14440)
                     /locus_tag="BN6_RS10425"
                     /old_locus_tag="BN6_21360"
     CDS             complement(13622..14440)
                     /GO_function="GO:0004332 - fructose-bisphosphate aldolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /function="Catalyzes aldol condensation between
                     L-aspartate-4- semialdehyde (ASA) and dihydroxyacetone
                     phosphate (DHAP), to form
                     2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099570.1"
                     /locus_tag="BN6_RS10425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21360"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="WP_015099570.1"
                     /transl_table=11
                     /translation="MSARPGGTAVRLARLARHREGRYLFVPLDHSVADGPIIAAGRFNW
                     LVRVAVEGGADAVVVHKGRVATLDPALLRACSLIVHLSASTAHGPDPDAKVLVGDVEEA
                     IQLGADAVSVQVNIGSATESRQLADLGAVADACRRWNVPLLAMVYPRGPAITDPHDPTL
                     LSHVVNIAADLGASLVKTTWPVPLERMAEVVESCPIPVLSAGGPGNRGVDPAAFAATLL
                     AHGCSGLAIGRGIFQSSSPASVIRAVSAVVHEEALSPVPVLDRVHSVPAR"
     gene            14733..15851
                     /locus_tag="BN6_RS10430"
                     /old_locus_tag="BN6_21370"
     CDS             14733..15851
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005444989.1"
                     /locus_tag="BN6_RS10430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21370"
                     /product="3-dehydroquinate synthase II"
                     /protein_id="WP_041312521.1"
                     /transl_table=11
                     /translation="MKFAWIDIRAVDARHREAVVDAAVHAGLGGVLDHRLETLATLPPT
                     VTKVLLPGPGEVPPAEAAGACDVVLTRVATFTELDKLKLVAGEVDAHAGAFVEVVDDLT
                     LRVACAAVQALEHTVVRFRDPTKIPLEIVIAAADRAPGLLVCEADGIEEARIVLDVLEK
                     GSDGLLVAPRDANDVFDVDKLLRTATPDLALTTLTVRSVEHNGLGDRICVDTCTHFRED
                     EGILVGSFAHGFVLCVSETHPLPYMPTRPFRVNAGALHSYVFGADNRTNYLSELKAGST
                     VLGVTADGRTRRIVVGRVKLESRPLLTVHATAPDGTEVALTLQDDWHVRVLGPGAAVLN
                     STELEPGDQLLGYLATDKRHVGWPVGEFCIEK"
     gene            15885..17315
                     /locus_tag="BN6_RS10435"
                     /old_locus_tag="BN6_21380"
     CDS             15885..17315
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (14-373). E-value: 1e-53.
                     Score: 174.3. Matches aSDomain:
                     nrpspksdomains_BN6_RS10435_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099572.1"
                     /locus_tag="BN6_RS10435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21380"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_015099572.1"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-36, bitscore:
                     122.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPGRDFEAWLDAALSDPDRRRLTWATHGETVVTRDALRTEVDRA
                     GRVLGASSITRGSTVAVQLLPSFTLLWSLFALWSRGAQVMLLDPRLTPTETTRLLELCR
                     PQFHLTTGGVARTFTPFRDQCEVLVRPMRSGAPAQGDHRLIQFSSGSTGLPKVIGRTGG
                     SLLTEVERFARLSDMPRLGENVLLLSSLAHSFGLIGGVLHALNAGAALHFAGRPNRGAL
                     LSVLAGRRIAAVLGVPAHYALLGRPGDVEPLPDLRLAVSGGEALPPEVFARFEELFGVR
                     IGQAYGMTETGIIATDLTGRHGPPAVGVPVPGLCTEVVDGTLRVRLAETPYLHVDADDR
                     YVDGWLHTRDRCVRRPGTNVLEITGRTDSLVSIGGLKVDLMEVEAVLAEHPDVREVVVV
                     YGEAVEAHLVIAPSLARSELLAWCHERLSTYKIPKAFHFRTALPRTSNGKPVRNRDLLH
                     ASGYTARSVVHSEVGQSA"
     aSDomain        15927..17003
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10435_AMP-binding.1"
                     /evalue="1.00E-53"
                     /label="BN6_RS10435_AMP-binding.1"
                     /locus_tag="BN6_RS10435"
                     /protein_end="373"
                     /protein_start="14"
                     /score="174.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSDPDRRRLTWATHGETVVTRDALRTEVDRAGRVLGASSITRGST
                     VAVQLLPSFTLLWSLFALWSRGAQVMLLDPRLTPTETTRLLELCRPQFHLTTGGVARTF
                     TPFRDQCEVLVRPMRSGAPAQGDHRLIQFSSGSTGLPKVIGRTGGSLLTEVERFARLSD
                     MPRLGENVLLLSSLAHSFGLIGGVLHALNAGAALHFAGRPNRGALLSVLAGRRIAAVLG
                     VPAHYALLGRPGDVEPLPDLRLAVSGGEALPPEVFARFEELFGVRIGQAYGMTETGIIA
                     TDLTGRHGPPAVGVPVPGLCTEVVDGTLRVRLAETPYLHVDADDRYVDGWLHTRDRCVR
                     RPGTNVLEITGRTDSLVSI"
     CDS_motif       16974..17036
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10435_0001"
                     /evalue="1.70E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="BN6_RS10435"
                     /protein_end="384"
                     /protein_start="363"
                     /score="11.2"
                     /tool="antismash"
                     /translation="TGRTDSLVSIGGLKVDLMEVE"
     gene            17312..18106
                     /locus_tag="BN6_RS10440"
                     /old_locus_tag="BN6_21390"
     CDS             17312..18106
                     /NRPS_PKS="Domain: Thioesterase (21-229). E-value: 3.5e-43.
                     Score: 140.6. Matches aSDomain:
                     nrpspksdomains_BN6_RS10440_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.5"
                     /locus_tag="BN6_RS10440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21390"
                     /product="thioesterase II family protein"
                     /protein_id="WP_015099573.1"
                     /sec_met_domain="Thioesterase (E-value: 1.1e-38, bitscore:
                     132.6, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.4e-08, bitscore:
                     33.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTWRDPWLRPVTGSRPDSAVRLFCLPYAGGSATVFRAWRSAAAD
                     VEVHAVQLPGRGRRVAEPPLHDARVLARRLAAALEPHLDRPYGIYGHSMGGIVGLALAH
                     ELARSRPPSGLFVGASVAPSSVRPVRVWRGTDEELLRWLEWVGGTPAHLLDRPGLRKLL
                     PVLRADLAVVAGYRGRPGERLAVPVTGFAGASDPFAGRSAMLGWERETDAGFTLSEVPG
                     DHFFLAGSGRLVLDSVTASLLAATRSGNYPTLVAQTTTVVEP"
     aSDomain        17375..17998
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS10440_Thioesterase.1"
                     /evalue="3.50E-43"
                     /label="BN6_RS10440_Thioesterase.1"
                     /locus_tag="BN6_RS10440"
                     /protein_end="229"
                     /protein_start="21"
                     /score="140.6"
                     /tool="antismash"
                     /translation="RLFCLPYAGGSATVFRAWRSAAADVEVHAVQLPGRGRRVAEPPLH
                     DARVLARRLAAALEPHLDRPYGIYGHSMGGIVGLALAHELARSRPPSGLFVGASVAPSS
                     VRPVRVWRGTDEELLRWLEWVGGTPAHLLDRPGLRKLLPVLRADLAVVAGYRGRPGERL
                     AVPVTGFAGASDPFAGRSAMLGWERETDAGFTLSEVPGDHFFLAG"
     CDS_motif       17561..17629
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS10440_0001"
                     /evalue="4.80E-07"
                     /label="NRPS-te1"
                     /locus_tag="BN6_RS10440"
                     /protein_end="106"
                     /protein_start="83"
                     /score="22.3"
                     /tool="antismash"
                     /translation="DRPYGIYGHSMGGIVGLALAHEL"
     gene            18143..19651
                     /locus_tag="BN6_RS10445"
                     /old_locus_tag="BN6_21400"
     CDS             18143..19651
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099574.1"
                     /locus_tag="BN6_RS10445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_21400"
                     /product="MDR family MFS transporter"
                     /protein_id="WP_015099574.1"
                     /transl_table=11
                     /translation="MGTHRPPATEGDSDRLTPELWWLSAIMAFGGFASLLDATIINVAV
                     GPLAAVFAADLDTVQWTITGYLLAITASLPLSGWATARFGAKQTVIFSQIVFLVGSVLS
                     GLAWSATSLIVFRVIQGIGGGLAVPVGQALLAQAAGPRRLGKLMAIVSIPALFAPVLGP
                     SLGGVLIDYLDWRWIFFINVPFCLVTIALVLAKVRNVVQPSRTAKLDALGLLLLMPGLV
                     GLIYGLAEAGSAGGFDSATTLVSLVAGVVLLVVFTVRALRKRQNPLLDLSLFRVRDFKN
                     GTAAGVLLSMAMYGVLIPLPLYFQLVQGTSVLESALLLLPQSIGYLIAVATMNRFASVL
                     GVRNLSLVGVVFVIAGTVPFALITADPNQVLLGAALVVRGMGLGLSMTLTMTIAYSSVS
                     KEVVPNATSAFNVFQRVGASLGTAVLAVVLQNQVAGLLPAGTTTLQQVEPGGDVAHGLA
                     SAFGAPFWWALAFTVVALLPVFFLPGRQSPATAPVRAPAPARAD"
     misc_feature    complement(19850..19865)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    complement(19850..19865)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    19851..19865
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
ORIGIN
        1 atgcaccgcg cagcgccggg ctcacgaccg gatccccgtc gatgcgaact gctccggcgc
       61 gagcttttcc ggtgcgaact cctctggtgc gaactcctct ggagcgaaat cctctgggcc
      121 gcaccagcgg accagcgcgg cgcccatgct gaagcccgag ccgaacgcgg cgagcaccac
      181 ctgatcgccg ggggacagcc ggccggtgtc ctcggcctcc cggagcacga ggggcacgct
      241 cgcgccggag gtgttgccgt acttctcgat gttgaccacc gtccggtcca tcggcacgcc
      301 gatggcggcc atgatctccc ggacgatgta gaggttcgcc tggtgcagcg cgaacaggtc
      361 gatgtcctcg acctcccgcc cggcggcggc gagcagctcc tcgacgaacg gcggcacctc
      421 gccgaccgcg agaccgtgca ccgcgttgcc gtccagcgtg gagaagttgt caccgaaccc
      481 gctggacagc cgggtgccgt cgcggcgggt ccgccgctcg cgcgcgaccc gcaccgcctg
      541 gtacgccgac gggtcgctgc gcagcagcgt cgtgccgatg ccgagtccgg gcgtgcaggg
      601 ctccagcagg tagcaggccg cgccgtcgcc gaagatgacc gcggggccgg ggtccttcca
      661 gtccatcgtc ctggtgctga cgtcggccag caccacggcg acccggcggt attgcccgga
      721 ggccaggtac ttggcgccca cgtcgagggc gaacacgcca ccggggcagg cgccgctgtt
      781 cacgtcgaac ccggccgccc ccaccgcccc ggacttgtcg atcacgagca tcgcggtggg
      841 cggcgccatg tggtccgggg tgtaggtgcc gcacacgacc aggtccactt cggacggacg
      901 cacgcccgcc cgggcgcagg cgtccagcag cgcggcggcg cccaggtcgg aggtccactg
      961 gtcgtcggcg gccatccgcc gggtccgcac cccgatgttc tcccggatcc agtcgtccct
     1021 ggtgagcagt atccgttcga ggtcggcgtt gctgacgacc cggtcgggca ggtacctgcc
     1081 gatcgaccgg atgcccacgc ccctcggtcg ggtgcgttcg cgcagatgct ccatggcggg
     1141 cccaacacct acttccgcgg gttcgggtga caacgtcggg tcagatgaat ttccgcttgt
     1201 tctcgcggcg gtccgccctg gccttctccc acgcgccgac cgcctcggcc agcaggtgcg
     1261 ggtgcccgtg cagcacctcg cccagcgcct tctccgcgtc ggccgggtcc gcgaggaact
     1321 ccgtccggtc gcggccgtcc agcgaccgca ggaagttctc gcccagcacg acgagcttcc
     1381 cgccgggcac cacccgcgag cacagcacgg tgtaggacag cggggactcc tcggaggtga
     1441 ggtggaagtc gacgatccac gcgtagtcgg ggatctccaa cggctcgtcg gcgaagcggt
     1501 agaccggcgt ccactcgtcg tccacgcccg agcgcagcac cgtgcggtag ccgtcccgct
     1561 cgaccacccg gaaccgccac ccgccgtcgg cctggggcgt gccggagagt cgcagcggct
     1621 cggtcgggga gtgcagcagg aacccgacgt cgaccagcca gtcctcgccc tcggcctcga
     1681 cgaccagcac gaggtggtcc cagcgcgacc accactcgcc gccgacccgc cacatctggg
     1741 ccgccaccaa tcgcgcccgg aacccgacgc cgcgcaggaa gcggccgagc aggggagtgg
     1801 tctccaggca cgtgccgccg cgccggcggc ggaccacccg gtcgaacgcg gcggtgtgct
     1861 ccaggtcagg tacggcgccg tcgagcacgt cgaggaactc gtacggcacg gcgtgcaggt
     1921 gggcggtggt cacggcgcgc aggtactcgg cggtcggctc cagcggtccg gtgtggccga
     1981 tgcgccgcag gtagtcgtgc cacggcaggg ctgcggtcgt ggcggtgcgg gacggggaag
     2041 cgacgtgttc caaggcactc tccgatggct gtcggtgcgc ggggctgcgc gacgtcaccc
     2101 cgtcggaatc gtggtccggc gccgcggcgg cggtaagacc cgaccgccct gctcgatggg
     2161 ctaggcggcg gtgcaccggt cgcggcgggt gttgtgccac gcggatcagg tcttggcggc
     2221 cccggcgggt gccgggagag ttcgcccggc gaccgaaacc gcgacccgga gggcacccga
     2281 tggacagcaa cgccgtcgcg gacggcggcc cggagccgac ggcccgctgg ggccgggccc
     2341 tgccgccgca cctggtcgac cggcagctgg ccgtccgcat gggcatcgag atcgtctcgt
     2401 gggaccccga ccggatggtc ggcacgatgc ccgtcgaggg caaccagcag ccgctgggct
     2461 ggctgcacgg cggggcgaac gccgtcctcg ccgagaccct cggctcgctg gcggccgggg
     2521 tccacgtcgc ctcgcgcggt gccgtcgcgg ggctcgaact gtcctgcacg caccacaggt
     2581 cggtccgccg gggcgtcgtc accggggtct gcaccccgtt gctgctgggc gaccgggtgg
     2641 tgacctacca ggtgtccatc agcgacgacc gcggccgact gacctgcacc gcccggctga
     2701 cctgcctggt gggcaagcgc tgaaccgaga ggcggtccca tgtccactcc agccgtgcgg
     2761 ctgccgggcg gccggtccgc cgacccgggg gagttccgca aggtgatggg gttgttcccc
     2821 acgggcgtca cggtggtcac ggcgggccgg ggcgagcgga ccgaggcggt gaccgcgagc
     2881 gcggtggcct cgatctcgct cgacccgccg ctggtgctgg tgagcctgcg cgccgccggg
     2941 aggctgccga cggcgatcga cggtgcgggt ggtttcgcgg tcaacgtcct cgccgccgac
     3001 caggagcgcc tgtccgcgct gttcgcggca cgcgatcggc cgcgcggcgt ggcggccttg
     3061 gaacgcctgg gcggcactgt cggcgcgagc ggccacgtcg tgctgcccag cgccgtgctc
     3121 tcactggagt gccggaccga gcaccgctat cccggcggcg atcacgtgct gttcctcggc
     3181 cgggtcctcg ccgtgcacgc ggccgagccg gtcaaggcgc ccctggtgca ccaccggggt
     3241 gcctaccacc gcctgcacca cctcagcgac tgaacaggag aagcgctcat ggcacgttcc
     3301 gtgctggtca ccgggggcaa tcgcggcatc ggtctggccg tggccaggaa attcgccgcg
     3361 cacggggacg cggtggccgt cacccaccgg ggttccggcg cccccgaggg cctgctgggc
     3421 gtcaagtgcg acgtgaccga caccgaccag gtgtcccggg ccttcgccga ggtggcggcg
     3481 gtcaacgggc cggtcgaggt gctggtggcc aacgcgggca tcacccggga cggcctgctg
     3541 atgcggatgg acgacgacca gttcctcggc gtgctggaca ccaacctcgg cggcgcgttc
     3601 cgggtggccc ggcacgcggc caccgacatg gtgcggcggc gcggcgggcg gatggtgttc
     3661 ctgtcctcgg tcgccgggct gcggggatca ccgggccagg ccaactacgc gtcgagcaag
     3721 gcggggctgg tgggcctggc ccgctcgctg gcccgcgagt tcgggtcgcg cggcatcacg
     3781 gtgaacgtcg tcgccccggg gctggtggac accgacatga ccgagcagct cagcgcgcag
     3841 cgcaaggagc agatcctggc cgacgtgccg ctggggcgca gcgccgctcc ggaggaggtc
     3901 gccgacgcgg tcttctggct ggcttcgccg ggcgcggcct acgtgaccgg tgcggtgctg
     3961 ccggtggacg gtggtctcgg gatgggccac tgacggtagc ccggcgcggg ccggttcggc
     4021 tcgccgctcc ggtccgcgcc accgatgcgg tgtcgtccgc cgccactcgg ggccgcgaac
     4081 ctcctgccgc gaacctcctg ccgcgaacct cctgccgcgg tccgcaccgc ggaccgggtg
     4141 cttcagcgtg ccacccggac cagcgcgtca ccccgcacgg tgaccggacc gtccacgacc
     4201 cggacggtga gcgacaaccg cacccgccgc tcgccgtcgt gctccgccag gtccttgacc
     4261 ttggccgcgc accggatccg ggcacccacc ggcgtggcgg cggcgaagcg cacccggaac
     4321 gacagcagat cggcgaccgg cacccattcg gtgaccagcc ggcccaggaa ccccatggac
     4381 agcatgccgt gcgcgatgac gtcggacagg cccgcggcgc gggccgcgtc cgggtcgagg
     4441 tggatggggt tggggtcacc cgaggcgtcc gcgaaccgga ccagcagcgc ccgggtgatc
     4501 cgcagctccg gcagctccgg cagctcggtg ccgacctcca cgtcggccag gctgaacgcg
     4561 ctcaccggtc ctccccgacg gacgcggaga ggcggaccgc gatgatctgg tggtggtcgg
     4621 cgaccggctc gccgtcggtg tcggtcaccg ccgtgtcctg cacgacgaac tccatcccgc
     4681 cgcgcccgta gatgtcggtg atcaccgtgg agaaagtcag ccgctccccg gcgtaggcgg
     4741 tgcggtggta gacgaacccc tgctcgacgt gcagcacgcg gcgcagctcc acccccatcg
     4801 cggtcaacac gtccgagggg ttccggaact ccagtccgaa caggaacgtc ggcgggaccg
     4861 ggagatccgg gtgcttcgcc gcccgcgcga ctccgaggtc ggcgaacacc ccgccgccga
     4921 cacccagcac ctcggcgaac gacgccacct cgctccggtc cacctccacg gtgaacggcg
     4981 cgagccgcgt gccgatgaac gcccggtcga tctcctgccc cctttcgcgc gtcggaccgc
     5041 catccaccga cgtgctgccg agccgtgcgg aacccacaac cgacctcctg cgctcgcgta
     5101 ccgggacctc gcgccagcat cgcgctcgcg gcccggcccg cgacagcccc gacgaacctg
     5161 tccgaccggc caccccgcat ggtgtgcgat ccggcgtgaa acctcgcccg gcaacggaaa
     5221 gcacgcatgt gcccggtcgg cgcgctccgg tgggcccctc gatcgggcac accgtccgcg
     5281 cctcccaccc gctgcccgga cccggcgaag ctggcggtgc gcccacagcg cggagcggtg
     5341 ccaccgcccg caagtcgtcg cccgtcgaat cgaggatcac catggctgtt ccggacgagt
     5401 ggtgggcagg gcacggcggc tacgccgccc gcgtcctgtc ggcactggtc gccgaccccg
     5461 accgggtcgc cctgcactgg cggggacgcg gcgtcaccgc ccgcgaggtg accgacgcgg
     5521 tcgccgggat cgccgacacc ctgcgccggc tggacatcgg gcagggggac gtcgtcggcg
     5581 tgatggtggc gcccaacagc ccggacatgc tcaccgcgcg ctacgcggcc cacctggtcg
     5641 gcgccgcggt ctgctacgtg cgatcgacca acccgggttc cgccgacccc gtgctgtccg
     5701 aggaggagca gctgcgcatc ctgctggaca cccgggcccg cgggctgttc accgataccg
     5761 ggaacgagga ccgcgcgaag cgactcgtgg accgggcgcg cggcctggtc gccctggtcg
     5821 gcttcgacct ggacccggcg ggggccacgg cggtggcttc cgccgaccgg gcgaacctcg
     5881 cgccggccgc cgcctgggac ccggcggcgc tcgcggtgat cggcttcacc agcggcagca
     5941 ccggccgggc caagggcatc agcctccagg ccagggcatg ggagagcacg gtggtcgcca
     6001 ccgaggagtc gatcaccgaa cccgaccccg cgatcctggt cacgaccccg ttgagccaca
     6061 cggtggcgcc gatggccgac gcggtgctgg cccggggcgg ggtcgtcgtc ctgcacgagg
     6121 agacccggcc ggggcccgtg ctcgacgccc tgcggcagca ccggatcacg cggacgttcg
     6181 tggccacccc ccacctgtac gagttgctcg accacagcag gaccgcgccg gccgacctgt
     6241 cgtcgctgcg gctgctcatc tacagcgggt cgccggcggc acccgcgcgg atcgcggagg
     6301 cggcgcgcgc gttcgggccg gtgctggtcc agggctacgg gaccagcgag tgcggccgga
     6361 tcacgttcct gggccccggc gaccacttcg acgagacggt gctgtccagc gtcggccacc
     6421 cgttcccgga gatcgaggtc gaggtgcgcg aaccgggttc cgaccgggcg gtggccgtcg
     6481 gcgagacggg cgaggtgtgc gtgcgctccc cgcacgtgat gcgcgagtac tgggccgacc
     6541 cggcgcggac gtcccgggtg ctgcgcgacg ggtggtaccg cacgggcgac atcggccggc
     6601 tcgacgagcg cggctacctg tacctgctcg accggatcgc cgacgtggtg aaggccgatg
     6661 gcgtcaaggt ctacccggcc gtggtggaac gcgagatcca gtcgatcccc ggtgtcgcgc
     6721 acgccgcggt ctacggggtc cgcgacgagg acaacgcgga gcacgtccac gccgcgatcg
     6781 tgctccgccc gggagcgcgg gtcggcgtgg acgaagtgcg cgagcgggtc cgcaccgcgc
     6841 tgtcggccgc gcacgcaccc gagcacgtgc ggctgctcga cgcgttgccg ctcaacggat
     6901 ccggaaagcc ggacaaggca cgactgcgcg gcgaggaact cgccgcgcgg gtgccccggt
     6961 gaccgcccgc gcatcgaacc gaccgtaccg agggagtggg ttgacgtgac gaaccggcac
     7021 atggacttct tcgtccgcga gatggcggac ttcggcccgc ggaagcggga gttcctcgag
     7081 atcgggcgca gggcgggcct gttccccagc gcggtggcgc gtcagggccc ggacggcacc
     7141 gaggccgaga tcagcgtctg gtgcagcaac gactacctcg gcatggggca gaacccgttc
     7201 gtcctggagg cgatcaagga cgcggtcgac gcgttcgggg ccggctccgg cggttcccgc
     7261 aacatcggcg ggaccaacca ctaccacgtc ctgttggaga aggagctcgc ggcgctgcac
     7321 ggcaaggagg ccgcgctgat cttcccgtcc ggctacaccg ccaacgacgg cgccctgtcc
     7381 gttctcgcgg gccgcgctcc ggacacggtg gtcttctccg accagctcaa ccacgcgtcc
     7441 atcatcgacg ggctgcgcca cagcggcgcc gagaagcgca tcttccggca caacgacgtg
     7501 gcgcacctgg aggaactgct ggccaccgcc gacccggacc gccccaagct ggtcgtagcc
     7561 gagtccgtgt actcgatgtc gggcgacatc gcgcccttgg cgcagatcgc cgaggtctcg
     7621 caccgctacc acgccacgac gttcctcgac gaggtgcacg ccgtgggcat gtacgggccg
     7681 cagggcgcgg gcatcgccgc ccgtgaagga ctggcggacc ggttcacggt cttcatgggc
     7741 acgctggcca agggcttcgg caccgccggc gggtacatcg ccggcccggc cgcgctggtg
     7801 gacgccgttc gcagctggtc gcggtcgttc atcttcacca cctcgctgcc gcccgccacc
     7861 gccgcgggcg ccctggccgc cgtccgacac ctcaggtcgt ccgaggtcga gcgggaacgg
     7921 ctcgcggcga acgcgcgact gatgcaccgc ctgctgaccg agcggcgcat cccgttcatc
     7981 tccgaccagt cgcacatcat cgcggtgttc gtcggcgagg accagttgtg ccgccaggcc
     8041 tccgcgctgc tgctgcggcg gcacgggatc tacgtccaag ccatcaacgc gccgagcgtg
     8101 cggaccggcg aggagatcct ccgggtcgca ccctcggcca cccacacggc cggcgacgtc
     8161 gagaagttcg tggaagcgct ggacggcatc tggcaggagc tcgggatccc caccgggccg
     8221 actgcgggat gacctggcgg gcggacgcgg ccgccgatca cggccggtgc gcggcggggg
     8281 agcgcgccga ggggagatcc cgtccccggc gctccccctt cgcccgacgg cgatcgccgt
     8341 cgggcgggtc gacgaggagg gagtcctgat gtccgtgtcg ttggcggccg tgctcgccga
     8401 gtccgccgcc cggtacccgg accggccggc ggtggtgttc gagtcgcgga agacgtccta
     8461 tcgggagctg tggtggtggg cgcggaagta cgcggcggtg ctgcgggacc acgggatcgg
     8521 gcgcggtgac cgggtcgcgc tgctgcttcc gaactcgcca cacctcccga tggcgtactt
     8581 cggcgtgctg gcgttgggcg cggtggtggt gccggtgcac gcgctgtcca aagcagacga
     8641 gatcgagcac gtgctgcggg actccggggc cgcggcgctg gtctgcgccg gatcgctgct
     8701 ggagcagggc ggtgaggccg cccggcgtgc cggcgtgccg gtgttcaccg tcgtggcgga
     8761 cgacgggctc cggttggacg tggcggccgg ccctgccgct ccgatcgaac ggtacgcgcc
     8821 gtgcgcgccc gacgacgcgg cgatggtcct gtacacctcg ggaacgacgg gcaagcccaa
     8881 gggcgcggtg ctgacgcacc tgggcgtcac gatgaacatc accgtcacga tgctgtcccc
     8941 gttcgacttc cgggccgacg acgtgttgct gggcgcgctg ccgctgttcc acatattcgg
     9001 ccaggtctgc ggcatgtgcg tgtgcttccg ggccggtgcc accctggtgc tgatgccggc
     9061 gttcgacgcg gcgcgtgcga tcgagttgat ggccgagcac cggtgcacgg tgttcatggg
     9121 cgtcccgacg atgtacatgg cgctgttgcg cgccatgggg acagcgacgg tgcgcccgcg
     9181 cctgcaccgc gcgtactcgg gtgggcaggc actgccggtg aaggtcctgg aggacttcga
     9241 ggaccggttc ggctgcccgg tctacgaggg gtacggcctg accgagacct cgccggtggt
     9301 cgcctacaac cagcctgcgt ggccgaggaa accgggcacc gtggggctgc cggtctgggg
     9361 cgtcgaggtg gccatcgccc gggccgacgt ggacggccgg gtcgagctgc tgcccgccgg
     9421 cgaggtgggc gaggtcgtca tccggggcca caacgtcatg gccggctacc tgaaccggcc
     9481 ggaggccacg gccgaggtcc tggtggacgg ctggttccgc tcgggcgacc tgggcaggaa
     9541 ggacgaggac ggctatctgt ccatagtgga ccgcaagaag gacgtggtgc tgcgcggcgg
     9601 gtacaacgtg tacccgcgcg aggtcgagga agtcctgatg cgccacccgg ccgtcgcgca
     9661 ggtggcggtc atcggcgttc cgcaccccac gcacggcgag gaggtttgcg cggtggtgct
     9721 cccggcgccg ggagcgcggc cgggcgccga tctcggggtg gagatcgaga cgtggagcaa
     9781 ggcgcggatg gcgccctaca agtacccgcg ccgggtggag ttcgtcgacg ggttcccgct
     9841 cggggtgggc ggcaaggtgc tcaaacgcga gctggtggcc cgcttcgccc gctgagcctc
     9901 accgccgtcc acgacgatcc ggacgtcggc gcaggagctt ccggacttcg acggcggtgc
     9961 tccggctcgg gacccgagcc ggagcacggc acttccgggt tcaccgtgcg gcgagctcca
    10021 gggctttgga gacggcccga ccgtaggact cggtgactcc gccgagcgag ccgttgaact
    10081 tcggtgcgac gaacctggcg agcagctcga agctgcgctt gagcgcgctc cggtccgccc
    10141 agtccaggac ggtgaccagc agccgcccga acccgcccgt ctcgtcctgc acgtcccgga
    10201 tggcctggac gcagtcgtcg accgagccga tgacgctgcc acgccggtcg atcagctcct
    10261 ccagcgcctt gcgcgcctcc gcccgggagt gcacccgcgg tgcgccgagc agggcccagt
    10321 actcgttgcg gtaccgcatc cagccgtcca cgatctcgtc cagggcctgc tcgcggctgt
    10381 cggacacgtg caccgacagc gccacccgcc agtcgccgcg gtcgagcttc cggccgtgct
    10441 cggccgccgc cgcctcggcg tgctgccact gcccgaccag gtcgccgatc cggctgcccg
    10501 gccgcggcgg gatgccgaag gagatcgggc tgatgccgta ctggcccgcg agccgcatgc
    10561 cgaacgggga gaccgcgctg gacaccgcca tcggcagtcc cgccggcgag tggggacgca
    10621 actgcaaccg ggcgtcccgc acctcgaacc agtcggtgcg cacggtcacc ggcacggtgt
    10681 cgtggagcag cttgtggatc acgtcgaggg cctcggcggt gcgccgtcgc gtgtccgccg
    10741 ggtcgatgcc cagcaggtgc atgtcggtcg ggatcgaccc ggccccgacg cccagcgtga
    10801 accgcccgcg cgtcagctgg tcgagctgga cggctcgcga ggcgaccatg aacgggtggt
    10861 ggtagggcag gctgaccacg ccggtcccga gccggatgtg ccgggtccgc tcggccgccg
    10921 tggcgatgaa cagctcgggt gagctgatcg tgccccagcc cgccgagtgg tgttcgccga
    10981 cccacagctc gtcgtagccg agctggtcga gccattcggc cagttcgagg tcgcgccaca
    11041 ggctcagcga cgggtcctcg ccgagcgggt ggagggggga gaggaaggcg ccgaagccga
    11101 tccggtccat tgtggactcc tcagtcagtg gtggacgtgt cggggtgggc cgccgcggtg
    11161 cacagcccga ccagctgccc gagccagccg tacgccggat gcggtgggtc cgctggcacg
    11221 gcggggcgcc cccgggtcgc gcggcgcagc agcagcgcca cggccgcgtc ttcgccgagc
    11281 ggcaggcgcc cgagcgggtg ttccgcgccg aggcggtcgc gcacccaggt gacccggtcg
    11341 ttcggcgcca gttccacgcc gatcaccagc acctgctcca gctcgtcgtc gaacagcagg
    11401 aggtcggcca gccgcagtgc cgaaccggcg aggtcctcgc acgccgaaac gcagctgacg
    11461 gggccggtga tgccgtactg acgggccagg tggcccagga tggaggtggt caccgactgg
    11521 aagaacagca gcgggctgtg cacctggccc gcgaccagct tccgcgtcgc gaggtcggag
    11581 gtggtggtgt cgccgcacgc cgtggcaagc acgatcgcgg tccgttcgcc gagcccgtgg
    11641 atcaggtcgc cgcccggcgc acccaggcac tgctcggcga ccgccgcgac cagcgggttg
    11701 aacctcgacg tgacgaagcc gggcacggag gtcaggtcga ccggcgccgc gccgggcacg
    11761 tcccgcgccc gctcacccca gggcgccagg caggccgcgc ccacgacggc acgcggtagg
    11821 tcggacgtcg tcatcgcaat cctctcggcg tggtggagca cggtgctcac acccgtttca
    11881 ggacgagcgc ggcgttcacc ccgccgaagg cggcgttgag ggacagcgcg tgggtgatcg
    11941 gcgcgcggcg gcccacgtcg ggcaggtagt ccaggtcgca ctcgggatcg ggcacccgca
    12001 ggctcgccgt cggcggcaac aggccctcgc gcagcgcgag cagcgtgatc accgcctcca
    12061 ccgcgccggt ggcctccagc atgtggccgg tgctgccctt ggtggagctg atgggcacgg
    12121 cgggcgcgtg cgcgccgagg atccggcgca ggccggcggt ctcggccacg tcgttgagcg
    12181 gggtgccggt gccgtgcgcg ttgacgtagc ccagctgccc cacgtccacc tcggcgctgc
    12241 gcagcgcggc ccgcgccgcc cggaccagtc ccttgccctt cgggtgcggc ttgatgacgt
    12301 ggtgggcgtc ggaggacatg ccccagccgg cgacctcggc gagcggttcg gcgcctcgcg
    12361 cccgggcgcg ctcggccgac tccagcacca gcacggccgc gccgtcgccg tgcagcaggc
    12421 cgtcccggtc ggccgcgaac ggccgcaccg cgccggacct gctcagcgcc ttgcccgagt
    12481 cgaacttcgc gaacacgtcc tcggtgacca ggtacgcgcc gccgcacacc accgcgtcgg
    12541 ccagcccgcg ccggacgagt tccgcgccgt ggccgatcgc gttcgtcgac gcgacgcagg
    12601 cgttgacgaa cgcgagccgg ggcgtgccga gcccgaacgc cgcgcccatc gactccggca
    12661 ggtgaccggg caggctgtcc actgtccggg ggttgccggg gtcccgaccc tcggcgtggt
    12721 cggtccagaa cgaccgcgcc gccgagtggt cgccgttggt ccccagcagc acgggcgcac
    12781 cggccgcgtc ggtgcccgac atgcgcagcg cctcggcggc gcacgcgtgc agcacctcgg
    12841 cctgcgtcgg cgtgtagccg ggcttgaccg gcacgccggg catctccggg ccgtcgccct
    12901 cgtaggtcgc ggcgtgcgcg gcgtggtagg gggtgctgtc gaagcgggtg accggcgcga
    12961 agccgggccg gccggtgaag acgttgtcca gcaacgcctc cggcccgaag ccgaaggcgg
    13021 tcaggacgcc gtacccggtg atcacgacct cacgggacat gccgtgctcc ttccagcgcg
    13081 ccggcctgca cccggcgcag gacgaggtgg agcgagccga tggagtcgct ggcggcgacc
    13141 tcgtcctcgt cctcggggcc gacgacgatc ccgtactgct cctccaggtg gtgcaacagc
    13201 cacaccgagg tcagcgagtc caggacgagt tcggtcgagc tgtcccactc ggcgagcggg
    13261 aggccggact cccgcaggag ccgcgccacg tcggactcgg tgatcacctg gccacgctgc
    13321 ccgcggcggc ggccgaccgc aggccgacca cggtgtccac cagcgcgccg aggtcgggca
    13381 cgaggtctgc ggtcagctcg tcctcctgga gttcgacgcc gtacgcgccc tccagctgga
    13441 gcaccagctc gatcatggcc agcgactcca gccccaggcc ctcctcgccg agcgggaggt
    13501 cgtcctcgac ccggtcgggc agcggaatgt tgatcacgtc cctgatcacg gtcaggatga
    13561 actctcgggt ttctgcgcgc atcggtgtct ccgttgggtg gtggtcggcc cggggctccg
    13621 ctcagcgggc cgggaccgag tggacgcggt cgagcacggg cacgggggac agggcttcct
    13681 cgtgcaccac ggccgagacg gcgcggatca cgctcgcggg cgaactgctc tggaagatgc
    13741 cccggccgat cgccagcccg ctgcacccgt gcgccagcag cgtcgcggcg aacgccgccg
    13801 ggtcgacgcc ccggttgccc ggaccgcccg ccgagagcac cgggatcggg cagctctcca
    13861 ccacctccgc catccgctcc agcggcaccg gccaggtggt cttcaccagc gacgcgccca
    13921 ggtccgccgc gatgttgacc acgtgcgaca gcagcgtcgg gtcgtgcggg tcggtgatcg
    13981 ccgggccgcg cgggtacacc atcgccagca gcggcacgtt ccaccggcgg cacgcgtcgg
    14041 ccaccgcgcc gaggtcggcc agctgccggc tctccgtggc ggagccgatg ttgacctgga
    14101 cgctcaccgc gtccgcgccc aactggatcg cctcctccac gtcgccgacc agcaccttgg
    14161 cgtcggggtc cgggccgtgc gcggtgctgg cgctcaggtg cacgatcaac gagcacgcgc
    14221 gcagcagggc agggtcgagc gtcgcgaccc gtcctttgtg gaccacgacg gcgtccgcgc
    14281 cgccctcgac cgccacgcgg acgagccagt tgaagcgccc ggccgcgatg atcggtccgt
    14341 cggcgaccga gtggtccagc ggcacgaaca ggtagcggcc ctcgcggtgt ctggccagcc
    14401 ttgcgagacg gactgcggtt cctcccggcc tggcggacat gatgcacccc tcgtcacccg
    14461 gaaaagcgcc tacgccgagg gagtctgccc aagccgggtg ggtaccggac cctcgatcgg
    14521 actgcccctg cgaacgcgtg cggcagcacc atcgaggtgc ccgaccggtc aggtccggcg
    14581 cgcacccgcc cggcacccgg tcgtgcaggt ccatcgaggc tgccccggcg cggtcgccgc
    14641 tgtgagggtt tgtcgcggtg cctcccgggc accggattcg tcccgaccgg cgggcttcgc
    14701 cgcactggaa cgcagtaggg ggatggttcg gagtgaagtt cgcgtggatc gacattcgtg
    14761 cggtggacgc gcgacaccgg gaggcggtgg tggacgcggc cgtccacgcc ggtctcggtg
    14821 gggtgctgga ccaccggctg gagacgttgg cgaccttgcc gcccacggtg accaaggtgc
    14881 tgctgcccgg cccgggcgag gtgccgcccg ccgaggccgc gggcgcgtgc gacgtggtgc
    14941 tgacccgggt ggcgaccttc accgagctgg acaagctgaa gctggtcgcc ggcgaggtcg
    15001 acgcgcacgc gggcgcgttc gtggaggtgg tggacgacct gacgctgcgg gtggcgtgcg
    15061 cggcggtcca ggcgctggag cacacggtgg tccgcttccg ggaccccacc aagatcccgc
    15121 tggagatcgt gatcgccgcc gccgaccgcg cacccggcct gctggtgtgc gaggccgacg
    15181 gcatcgagga ggcccgcatc gtcctggacg tgctggagaa gggctcggac ggcctgctgg
    15241 tggcgccccg cgacgccaac gacgtgttcg acgtcgacaa gctgctccgc acggcgaccc
    15301 cggacttggc gctgaccacg ctcaccgtgc ggtcggtgga gcacaacggg ttgggcgacc
    15361 ggatctgcgt ggacacctgc acccacttcc gggaggacga ggggatcctg gtcggctcct
    15421 tcgcccacgg tttcgtgctg tgcgtcagcg agacccaccc gctgccctac atgccgaccc
    15481 gcccgttccg ggtgaacgcc ggggcgctgc actcctacgt gttcggcgcg gacaaccgca
    15541 ccaactacct cagcgagctc aaggcgggca gcaccgtgct gggggtgacc gcggacgggc
    15601 gcacccgccg catcgtcgtc ggccgcgtga agctcgaatc ccgcccgttg ctgacggtcc
    15661 acgccacggc gcccgacggc accgaggtcg ccctgaccct ccaggacgac tggcacgtgc
    15721 gcgtcctggg ccccggtgcg gcggtgctca acagcaccga actcgaaccg ggcgaccagc
    15781 tgctgggcta cctggccacc gacaagcgcc acgtcgggtg gccggtcggg gagttctgca
    15841 tcgagaagtg acccgggcgg atcccggcga ggaaggacct caagatgact ccaggcaggg
    15901 acttcgaggc gtggctggac gccgcgctgt ccgacccgga ccggcgccgc ctcacgtggg
    15961 cgacgcacgg cgagaccgtc gtgacgcgcg acgcgctgcg cacggaggtc gaccgggccg
    16021 ggcgggtgct cggggcgtcc tcgatcaccc ggggcagcac ggtcgcggtg cagctgctgc
    16081 ccagcttcac gctgctctgg tcgctgttcg cgttgtggtc gcgcggcgcc caggtgatgc
    16141 tgctcgaccc ccggctcaca cccaccgaga ccacccggct gctggagctg tgccggccgc
    16201 agttccacct caccaccggt ggcgtcgcgc ggaccttcac cccgttccgc gaccagtgcg
    16261 aggtcctcgt gcggcccatg cggtcgggtg cgcccgcgca gggcgaccac cggctgatcc
    16321 agttcagctc cggttccacc ggcctgccca aggtgatcgg gcggaccggg ggctcgctgc
    16381 tgaccgaggt cgagcggttc gcgcggctgt ccgacatgcc gcgcctcggt gagaacgtgc
    16441 tgctgctcag ctcgctggcg cactcgttcg gcctgatcgg cggggtgctg cacgcgctga
    16501 acgccggtgc ggcgctgcac ttcgccggtc ggccgaaccg gggcgcgctg ctgtcggtgc
    16561 tggccgggcg ccggatcgcc gccgtgctgg gtgtaccggc acactacgcc ctgctcggca
    16621 ggcccggtga cgtggagccg ctgccggacc tgcggctcgc cgtctccggc ggggaagccc
    16681 tgccgccgga ggtgttcgcg cggttcgagg agctgttcgg tgtccggatc gggcaggcgt
    16741 acggcatgac cgagaccggg atcatcgcga ccgacctcac cggccgccac gggccgcccg
    16801 ctgtcggggt gccggtgccc ggcctgtgca ccgaggtggt cgacggcacg ctgcgggtgc
    16861 gcctcgccga gacgccctac ctgcacgtgg acgccgacga tcggtacgtg gacgggtggc
    16921 tgcacacccg cgaccggtgc gtgcgccgac ccggcacgaa cgtcctggag atcaccgggc
    16981 gcaccgattc cctggtgtcg atcggcgggc tcaaggtcga cctgatggag gtggaggcgg
    17041 tgctcgccga gcacccggac gtccgcgagg tggtggtcgt ctacggcgaa gccgtcgagg
    17101 cgcacctggt gatcgccccg tcgttggcgc gcagcgaact gctcgcctgg tgccacgagc
    17161 ggctgagcac gtacaagatc cccaaggcgt tccacttccg gacggcgctg ccacgcacgt
    17221 cgaacggcaa gccggtgcgc aaccgcgacc tgctgcacgc gtcggggtac accgcccggt
    17281 cggtcgtgca cagcgaggtc gggcagtcgg catgagcacg tggcgagacc cgtggctgcg
    17341 accggtcacc ggatcccggc cggacagcgc cgtacggctg ttctgcctgc cctacgccgg
    17401 gggcagcgcg acggtgttcc gcgcctggcg gtccgccgcc gccgacgtgg aggtgcacgc
    17461 cgtgcagctg cccggccggg ggcggcgggt cgccgagccg ccgctgcacg acgcccgggt
    17521 gctggcccgg cggctggcgg cggcgctgga gccgcacctg gaccgcccgt acggcatcta
    17581 cggccacagc atgggcggga tcgtcggcct cgcgctggcg cacgaactgg cgcggtcgcg
    17641 cccgccgagc gggctcttcg tcggagcgag cgtcgcgccg tcctcggtgc ggccggtacg
    17701 ggtgtggcga gggaccgacg aggagctgct gcggtggctg gagtgggtgg gcggcacgcc
    17761 cgcgcacctg ctggaccggc ccgggctgcg gaagctgctg ccggtgctgc gagccgatct
    17821 ggcggtggtg gcggggtatc gcgggcggcc cggtgagcgg ctcgcggtgc ccgtcacggg
    17881 gttcgccggc gcgtcggacc cgttcgccgg ccggtccgcg atgctcggct gggagcggga
    17941 gaccgacgcc ggcttcacgt tgtccgaggt gcccggcgac cacttcttcc tggcgggctc
    18001 gggtcgcctg gtgctcgact cggtgaccgc ctccctgctc gcggcgaccc gatcgggcaa
    18061 ctatccgaca cttgttgcgc aaacgacgac tgtcgtggaa ccatgacgcg atcgaatccg
    18121 tcgacgaggg ggacagccag ccgtgggaac tcaccgacct ccggccaccg agggcgactc
    18181 ggaccggctc acaccggagc tgtggtggct gagcgccatc atggcgttcg gcggattcgc
    18241 cagcctgctc gacgccacga tcatcaacgt cgcggtcggc cccctggccg cggtgttcgc
    18301 cgccgacctg gacaccgtcc agtggacgat caccggctac ctgctcgcca tcaccgcctc
    18361 gctcccgctc agcggctggg ccaccgcgcg gttcggcgcc aagcagaccg tcatcttctc
    18421 ccagatcgtc ttcctggtcg gctcggtgct gtccgggctg gcctggtcgg cgaccagcct
    18481 catcgtcttc cgggtgatcc agggcatcgg cggcggcctc gcggtgccgg tcgggcaggc
    18541 gctgctggcg caggccgccg ggccgaggcg gctgggcaag ctgatggcga tcgtctccat
    18601 acccgcgctg ttcgcgccgg tgctcggccc gtcgctgggc ggcgtgctga tcgactacct
    18661 ggactggcgg tggatcttct tcatcaacgt gccgttctgc ctggtgacca tcgcactggt
    18721 gctggccaag gtccgcaacg tcgtccagcc ctcgcggacc gcgaagctgg acgcgctcgg
    18781 cctgctcctg ctgatgcccg ggctcgtcgg cctgatctac gggctggccg aagccggctc
    18841 ggcgggcggg ttcgacagcg cgacgaccct cgtcagcctg gtggccggcg tcgtgctcct
    18901 ggtggtgttc acggtgcggg cgctgcgcaa gcggcagaac ccgctgctgg acctgagcct
    18961 gttccgggtc cgcgacttca agaacggcac cgcggcgggt gtcctgctga gcatggcgat
    19021 gtacggcgtg ctcatcccgc tgccgctgta cttccagctc gtgcagggga ccagcgtgct
    19081 ggagtcggcg ttgctgttgc tgccgcagag catcggctac ctcatcgcgg tcgcgacgat
    19141 gaaccgtttc gcgtcggtgc tgggggtgcg caacctgtcg ctcgtcggcg tggtgttcgt
    19201 gatcgccggc acggtcccgt tcgcgctcat caccgccgac cccaaccagg tcctgctggg
    19261 cgcggcgctg gtcgtgcgcg gcatgggtct ggggctgtcg atgacgctca ccatgacgat
    19321 cgcctacagc agcgtgtcca aggaggtcgt cccgaacgcc accagcgcgt tcaacgtctt
    19381 ccagcgcgtc ggcgcgtcct tgggcaccgc cgtgctcgcg gtggtcctcc agaaccaggt
    19441 ggccgggctg ctgccggcgg gcaccacgac gctccagcag gtcgagcccg gcggcgacgt
    19501 cgcgcacggc ctggcgtccg cgttcggtgc gccgttctgg tgggcgctgg ccttcacggt
    19561 ggtggcactg ctgccggtct tcttcctgcc ggggcgccag tcgcctgcca ccgcaccagt
    19621 gcgggcgccg gcgccggcgc gggcggactg accggtcggg agccccggcc cgggtcaggc
    19681 gaaccggggc tccggccaca tgtccgacag ccggcgcagc gcggcccggt gccgcccgag
    19741 ctgctcctcc gggccggcca gctccagggc caggcaccgc gccaactccg ggaaccggta
    19801 gtgcaaccgc gcgtcgcccc gaatcaccac cacgtccaag agccgcgcgt cgaccagccg
    19861 ttccagcacc tcgtccgcct cggcggaggt gaggtcgagc agcagggccg cggcccggga
    19921 cggaaagtgc ggcacgtccg gcagggacag cagccggaac gcgtgcctgg cctgctcgtc
    19981 caacccccgg tagccggaaa tcaggcgtgc ccgcacgtcc aggtcggcca cccgcagctc
    20041 gtccagccgg ccgcgccggt cggtcagcag gcccgccagc cgggacaggg tccagtgcgg
    20101 cttggcggcc agccgggcgc ccgcgatccg caccgccagc ggcaggtgcc cgcacagctc
    20161 cacgatgcgt tgcgccgcac cgggttccgc ccggaatcgg tcgacgccca cgatcgcgtg
    20221 cagcaggccg agcgactcgt gcggcgacgg caggggcagg tcgaccagcg cggcgccctc
    20281 cagcgcgacc agcctgcggc gggcggtgac gacgaccgtc gaaccgggcc cgccgggcag
    20341 cagcggccgt acctggctct cgctgaccgc gtcgtccagc aggatcagca cccgcttgcc
    20401 gacgatccgg ctgcggtaca gccggatccg gtcctccagg gtgtccggca cagccgtgcc
    20461 ccacagcgcg gtcagcatca cggcgagcgc ttcggccggg tcgacggggc gcccgctccc
    20521 gccgaggtcg acgtgcagtt gaccgtccgg gtagtccgac cggcactggt gggcggcgtg
    20581 caccgcgagc gccgacttgc cgacaccggc catcccggac agcacgcaga ccgagccgtg
    20641 ccgccgcatc gccccgacga ccaggtcgac ctcgcgggcg cggccggtga agtcggcgat
    20701 gtcggcgggc agttgcgcgg gcggcgcccc gatcgcgatc gtcgcgcgga ccgcgggcga
    20761 ggcctgccgc gcggtgagga tccggttgtg cagctcctgg aggtctgcgc cgggatcgat
    20821 gcccacctcg tcggccagca gccggcggta gtcgtcatag gtcgtcaggg cttcggcctg
    20881 ccggccgctg ccgtgcagcg ccagcatcag ctgggcccgc tgtcgttccc gcagggggtg
    20941 cgcggcgacg aacccggtca gttcggagac gacgccggcg tgcgcgccca ggttcaggtc
    21001 tgcctgcacc cggtcctccc agaccgccag cctcgcctcc tccagccggg ggcgttcggc
    21061 gtcccccagg aagtcggtca ccccggacag cgccggaccg cgccagagcg
//
