LOCUS       NC_019673              22532 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Saccharothrix espanaensis DSM 44229, complete sequence.
ACCESSION   NC_019673
VERSION     NC_019673.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Saccharothrix espanaensis DSM 44229
  ORGANISM  Saccharothrix espanaensis DSM 44229
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Saccharothrix.
REFERENCE   1
  AUTHORS   Strobel,T., Al-Dilaimi,A., Blom,J., Gessner,A., Kalinowski,J.,
            Luzhetska,M., Puhler,A., Szczepanowski,R., Bechthold,A. and
            Ruckert,C.
  TITLE     Complete genome sequence of Saccharothrix espanaensis DSM 44229(T)
            and comparison to the other completely sequenced Pseudonocardiaceae
  JOURNAL   BMC Genomics 13, 465 (2012)
   PUBMED   22958348
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9360653)
  AUTHORS   Rueckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2012) IGS, CeBiTec, Bielefeld University,
            Universitaetsstr. 27, D-33335, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000328705.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:06:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,451
            Genes (coding)                    :: 8,313
            CDSs (with protein)               :: 8,313
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 43 of 138
            Pseudo Genes (incomplete)         :: 116 of 138
            Pseudo Genes (internal stop)      :: 7 of 138
            Pseudo Genes (multiple problems)  :: 27 of 138
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:45:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1610106
            Orig. end                         :: 1632638
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE804045.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22532
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22532
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22532
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12532](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12532)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(8..21)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.73"
                     /tool="antismash"
     misc_feature    254..267
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.44"
                     /tool="antismash"
     misc_feature    complement(317..331)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.95"
                     /tool="antismash"
     misc_feature    317..332
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.35"
                     /tool="antismash"
     misc_feature    complement(491..505)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     misc_feature    complement(602..616)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            806..2182
                     /locus_tag="BN6_RS07670"
                     /old_locus_tag="BN6_15630"
     CDS             806..2182
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098999.1"
                     /locus_tag="BN6_RS07670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15630"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_015098999.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.9e-49, bitscore:
                     166.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDFDVIVIGGGPVGENAAARTAAGGLKTALVEAERVGGECSYWA
                     CMPSKALLRPGHALAAARRVPGVPVGERLDPAAVLKRRNGFTSDWDDSGQVGWAEGAGL
                     EVVRGRGRLVGERQVEVDGRVLTASRAVVVCTGSVPRIPKLPGLADVSYWTSREATSAQ
                     EVPTSLVVLGGGVVGVEMAQAWARLGSAVTLVVSGARPLPKFEDFAGDLVLDGLREDGV
                     TVRTGVKATGVSTVDGDIALALSDGTSVAGAHLLVATGRQPATFDLGVEGFGFTAGDAL
                     PVDDTGRVDGVDWLYAAGDVTGRALLTHQGKYAARAVGTAIVTGATDPEPWTAPVATAD
                     HTAVPQVVFTDPEVASVGWTEAQAREAGLDIRVVDLDIAVAGSSLHADGYRGKARMIVD
                     ERRRTLVGVTFAGPDTAELVHAATIAIVGEVTVDRLWHAVPAYPTISEVWLRLLEAYGL
                     "
     gene            2301..2672
                     /locus_tag="BN6_RS07675"
                     /old_locus_tag="BN6_15640"
     CDS             2301..2672
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099000.1"
                     /locus_tag="BN6_RS07675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15640"
                     /product="hypothetical protein"
                     /protein_id="WP_148302767.1"
                     /transl_table=11
                     /translation="MTRGTVALATAAVLWCAFLIGTTLTPGGPEFTPFVVHLPGFLVAP
                     VVLFTLLRARSNAVLCLAHVPKSLLGLGFAVAVAGWLFSCGALTGRPGTEMLCTVAGLA
                     IVLHVAFGLIAVGLVRTGR"
     gene            complement(2812..4056)
                     /locus_tag="BN6_RS07680"
                     /old_locus_tag="BN6_15650"
     CDS             complement(2812..4056)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099001.1"
                     /locus_tag="BN6_RS07680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15650"
                     /product="hypothetical protein"
                     /protein_id="WP_015099001.1"
                     /transl_table=11
                     /translation="MRLIRLGAEPTQIGVDVRAALSTWGTGDSVLGGVAMLGVTPPDCP
                     RTLDAVIVLPRGVLVVVGVDLPDPAMRLEAPLAGQWRIDGWPLTRPDGATSPAAEALAA
                     TTAVARRIQDMRGEPLPVTTVVAVGPYVAHVVQPTGDLNRGVRVLHPKPTTLLAAAREL
                     ATSDRPCSAEHAAKLLAVLAPTGIPPDTRQLRAEGFPDAAADLASASTMLLPKVPPAPR
                     RPRWLPYAAAGVVAVLLVVGLVVTLTSGGESAATQSASSTPQPTTVVVDGRNFTPKGAD
                     RSEDCAKHAFGDVQVWLSGHMCMQLRRAQYETVVDGRKVGVAVSELNLPDAARAGELRQ
                     VASAAGSGGVTALVKDGRTWPGGPVSFDRSAIRTATKTNQVRIAQVVWAEGESDPADPA
                     LTALADQALRLPSTQ"
     gene            4460..4960
                     /locus_tag="BN6_RS07685"
                     /old_locus_tag="BN6_15660"
     CDS             4460..4960
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009074684.1"
                     /locus_tag="BN6_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15660"
                     /product="DUF3145 domain-containing protein"
                     /protein_id="WP_015099002.1"
                     /transl_table=11
                     /translation="MSTRSTSGVVYVHSSPSAVCPHVEWAISGTLGERADLKWAAQPAA
                     PGQLRAECAWDGDAGTGARLVAALRAWPMVRFEVTEDPSPGVDGVRYCFAPVLGLWHAR
                     TSANGDIVVSEDQLRALAARSRGGESFAHGVDEILGAAWDDALEPFRRAGDGAPVTWLH
                     RVG"
     gene            complement(5240..6202)
                     /locus_tag="BN6_RS07690"
                     /old_locus_tag="BN6_15670"
     CDS             complement(5240..6202)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_15670"
                     /product="hypothetical protein"
                     /protein_id="WP_041312240.1"
                     /transl_table=11
                     /translation="MHSWIKPLVVLAVCATTVTACGKTDEIGDVAPPLPGENGLPALPG
                     DSEKGGKAPIGHIGFQPPIVPITFTINTKGEISVAVSAEIVTPFGKVKVGVNQRLDEDT
                     VTDEEDRELPPPPADEREVIICPAEQTPTRCDRYTIHTGRKLRVAIDGKVVQHIDTRRQ
                     VLFTAPGTRIKVTDDGPAPVTGTPGPARVDIEEFKFHATGQDTEVDLERSRSGYRSDLA
                     YNHISGELKAINGARIGRIENYGVRDLWRNLDAQSLPGEKECGETGDWRESFADGDFTD
                     DLTVACVKTAEGDLGYLVLGRLADRRPPAYRVYSHVWVR"
     misc_feature    complement(6246..6259)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    6247..6262
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.35"
                     /tool="antismash"
     gene            complement(6347..8047)
                     /locus_tag="BN6_RS07695"
                     /old_locus_tag="BN6_15680"
     CDS             complement(6347..8047)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /function="ABC-type multidrug transport system, ATPase and
                     permease components"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099004.1"
                     /locus_tag="BN6_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15680"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015099004.1"
                     /transl_table=11
                     /translation="MGPYLRALAGRRRAVLALLGWSVLEGVPALLGGRLVGLAVDRGFA
                     VGDVRTGVAWLVAFAVLAVLGGFGLRQVFTRLGDVVEPLRDGLVTAIVRGVLRDGRSHR
                     RQPDASAVARITRHVEVVRDATAGLLIQARALLVTTTAALVGLATAVSPLAWLVVLPVV
                     AALVLFGLLLPSLARGQRALVMADEDAAEAAGTVLLGMRDVVACGGRSRAAEDVGRQVD
                     RQARATVRMAWSTALRGIVIAVGGFLPLVLLLVLTPGMVAAGTLTAGEVLAAVVYLSTS
                     VQPALRRLADTTSTVVLRLAVALRRLAEAAPEVPEEAGDLVPGEGGVVLRGVTFGWGEH
                     AEPVVRDLDLDLARGAHLAVVGPSGIGKSTLAGLVTGLVAPQAGTVLLGGAPVREVRPD
                     VRHARIALVPQETYLFTGTVRENLALFAPTAGDDDLLAAVTAVGAADVVARLGGLDGSV
                     GHAGGSLSAGEAQLLAVARVYACPADVVVLDEATSNLDPAAEAVVERAFAARDGILVVI
                     AHRLSSALRAGQVLVMDGGPPLLGTHERLMAESPTYADLMAAWQPATAA"
     gene            complement(8047..9639)
                     /locus_tag="BN6_RS07700"
                     /old_locus_tag="BN6_15690"
     CDS             complement(8047..9639)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /function="ABC-type bacteriocin/lantibiotic
                     exporters,contain an N-terminal double-glycine peptidase
                     domain"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099005.1"
                     /locus_tag="BN6_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15690"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_015099005.1"
                     /transl_table=11
                     /translation="MLLRTVVLRDPRWLLLAGNALLATTAGLLLPTALAGAVDMALGGR
                     LDPGTVLWLAGLVGVEVVGDAIGVVLAAAIAARGTAFLRRKVIGKLVGLGHPGRFEAGD
                     AVSRLTGDSAIAGNFAVLLVNLGITVMTAGGAVVALTLLDWRLAAVFLLSVPLALLLVR
                     SHLRLTADDVATYQEVSGELSARLLDAVGGLRTIAASGRADQEADRVLRPLPRLAAAGV
                     GMWRTQAKMIWRAGLLLPAVELAVLTAAGFGVVAGRLSIGDVLAAMAYAALGMTVVGQA
                     AVLTAVQRARASAGRIDEVLAQEPVAAGAPGYAPPGAVELRGVCVPDALHDVDLLVPSG
                     MFLAVVGRSGSGKSALAAVIGGLTAPSAGRVARGGSVGYAFERPALLGATVADTVAYGT
                     SLGRPEVEEACRAVRVHDVVVRLPDGYDTPMADTPLSGGEAQRLGLARAVVRDPQVLVL
                     DDATASLDTVTESAVERAIASALPGRTRVVVTHRAATARRADAVVWLEDGRVRAMASHL
                     SLWENAEYRAVFG"
     gene            complement(9794..9955)
                     /locus_tag="BN6_RS44805"
     CDS             complement(9794..9955)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800163.1"
                     /locus_tag="BN6_RS44805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_085983487.1"
                     /transl_table=11
                     /translation="MEFILDLQDMDTPEVQSNAMASGGSSGGGGSTTASSVSLLLPCSH
                     SSASLLLC"
     CDS_motif       complement(9890..9955)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEFILDLQDMDTPEVQSNAMAS"
                     /locus_tag="BN6_RS44805_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9794..9889)
                     /prepeptide="core"
                     /locus_tag="BN6_RS44805_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="12.60"
                     /molecular_weight="2577.8"
                     /monoisotopic_mass="2576.3"
                     /core_sequence="GGSSGGGGSTTASSVSLLLPCSHSSASLLLC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEFILDLQDMDTPEVQSNAMAS"
                     /leader_location="[9889:9955](-)"
                     /alternative_weights="2595.9"
                     /alternative_weights="2613.9"
                     /alternative_weights="2631.9"
                     /alternative_weights="2649.9"
                     /alternative_weights="2667.9"
                     /alternative_weights="2686.0"
                     /alternative_weights="2704.0"
                     /alternative_weights="2722.0"
                     /alternative_weights="2740.0"
                     /alternative_weights="2758.0"
     gene            complement(10001..12532)
                     /gene="lanKC"
                     /locus_tag="BN6_RS07705"
                     /old_locus_tag="BN6_15700"
     CDS             complement(10001..12532)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099006.1"
                     /locus_tag="BN6_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15700"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_015099006.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1042.3,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-08, bitscore: 33.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8e-09, bitscore: 33.7,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYEAYCFADRLFYDVQSSTEIAADDFSQVLPELPADWARADL
                     TIWRYLQPAGAVLPRQGWKIHVSATVGNAGEVLLACYEHLVARRIPFKYLRTRSIVLAR
                     NSKYAPREASGKLITIYPADEAQLEKTLRELDELLAGQPGAYILSDLRYAAGPLFVRYG
                     GFVEQWLEVDGRRVLAIEGATGELVPDQRKPTFWVPDWITLPKCLEEHLAARKGGDADS
                     FPYRVTQSLHFSNGGGVYRATRKSDGADVVLKEARPHAGLDRDNVDAVARLRREHDILT
                     LLSGVPGVPAAHELFSAWEHEFFAMQPVPGRPIGQWLGQHYPLTHYDVGDLSEYTARAL
                     AIVADVERIVADVHARGVVFSDLHPLNVLVDDDDAVSLIDFELAFRVEEDRRPTLGSPG
                     FQAPPDRSGFEIDDYALAALRLYVFLPLNAVIELSPAKLRHHVEFIRRRFGLPDDYCDR
                     IVEVLTPRVDPPVRVSTALDEPTPDWAVVRKSIAAAILASATPQRHDRLFPGDVEQFEV
                     GGACFAYGAAGVLHALDVAGEGRFPEHERWLLDSLRRDPPKEPGFYTGAHGIAHVLENF
                     GYHDEADELVREYAELLPDTKDHGLNAGLSGVALNLLHFAVRRDDESFADRALDLGDRL
                     VGMLADAPPPGDKARAGLLHGWSGPALLFTRLHELTGERRWLDHAERALERDLAECMTA
                     LDGSTQVRDGTLRTLPYVGIGSAGIALALDEFARVAPDAACSARLPELVSGLTCEFVIQ
                     PAFMVGRAGLLATLAQAGGTREAVDRHLSALAWHAVPYQEGLAFPGVQLRRLSMDLNTG
                     GAGVLLALASAVDGVPALPFLTAPALAGRLQ"
     misc_feature    12487..12501
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.34"
                     /tool="antismash"
     misc_feature    complement(12834..12849)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.03"
                     /tool="antismash"
     misc_feature    12920..12935
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.86"
                     /tool="antismash"
     misc_feature    12927..12940
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.75"
                     /tool="antismash"
     misc_feature    12927..12941
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.8"
                     /tool="antismash"
     misc_feature    12996..13009
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.06"
                     /tool="antismash"
     misc_feature    complement(12996..13009)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.49"
                     /tool="antismash"
     gene            13034..13606
                     /locus_tag="BN6_RS07710"
                     /old_locus_tag="BN6_15710"
     CDS             13034..13606
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_15710"
                     /product="hypothetical protein"
                     /protein_id="WP_051075469.1"
                     /transl_table=11
                     /translation="MSSRLLLPAVLVVAALTAATGALAREVYQRPAQAVGDRIALPSDS
                     SPVPRADQPGSPTVQRSPDAALHPDGERVRALLQRYFDAINARDYDQWATTVTTERVAR
                     TPRARWESDYETTRNGTILVHRVETVSPTRVRVLMTFVSTQALAKAPADLQADCIRWRV
                     VYPVQEEAGNLRVDFGTEGSSSQFTAC"
     gene            complement(13792..15027)
                     /locus_tag="BN6_RS07715"
                     /old_locus_tag="BN6_15720"
     CDS             complement(13792..15027)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (65-408). E-value:
                     1.3e-50. Score: 164.5. Matches aSDomain:
                     nrpspksdomains_BN6_RS07715_PKS_KS.1"
                     /codon_start=1
                     /function="3-oxoacyl-(acyl-carrier-protein) synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017984122.1"
                     /locus_tag="BN6_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15720"
                     /product="beta-ketoacyl synthase"
                     /protein_id="WP_015099008.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 9e-56, bitscore:
                     188.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="FabF (E-value: 1e-164, bitscore: 547.1,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVNDVVVTGLGATTPLGGDVASTWDALLAGRSGVKPLVTDWVE
                     RFELPVRIAARLAVEPTEILPRVEARRLDRCEQVAVVAARQAWADSGLGDDGVEPERLG
                     VVVGTGIGGAMTLLDQDDLIEASGLRKVSPLTVPMLMPNGPAAHVGLDLKARAGVHAPV
                     SACASGAEALAWAWRMLRAGEADVVVAGGAEACITTITMAGFIQARTMSTRNDEPERAS
                     RPFDVNRDGFVLGEGAGILVLERGDFARARGARVYGTLAGIGTSSDGHHITAADPEGLG
                     QSRAIATALRNAGVDASDVGHVNCHATSTQVGDVIEPLAVRRAIGDHPVLTAPKGNHGH
                     LLGASGAVEAITTLLSVRDGVVPPTLNLENQDPKVQLEVVTGEPRKIDLVAAVNNSFGF
                     GGHNVSLVFTNG"
     aSDomain        complement(13804..14832)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS07715_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.30E-50"
                     /label="BN6_RS07715_PKS_KS.1"
                     /locus_tag="BN6_RS07715"
                     /protein_end="408"
                     /protein_start="65"
                     /score="164.5"
                     /tool="antismash"
                     /translation="PRVEARRLDRCEQVAVVAARQAWADSGLGDDGVEPERLGVVVGTG
                     IGGAMTLLDQDDLIEASGLRKVSPLTVPMLMPNGPAAHVGLDLKARAGVHAPVSACASG
                     AEALAWAWRMLRAGEADVVVAGGAEACITTITMAGFIQARTMSTRNDEPERASRPFDVN
                     RDGFVLGEGAGILVLERGDFARARGARVYGTLAGIGTSSDGHHITAADPEGLGQSRAIA
                     TALRNAGVDASDVGHVNCHATSTQVGDVIEPLAVRRAIGDHPVLTAPKGNHGHLLGASG
                     AVEAITTLLSVRDGVVPPTLNLENQDPKVQLEVVTGEPRKIDLVAAVNNSFGFGGHNVS
                     LVF"
     CDS_motif       complement(14077..14121)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS07715_0001"
                     /evalue="5.00E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="BN6_RS07715"
                     /protein_end="317"
                     /protein_start="302"
                     /score="9.7"
                     /tool="antismash"
                     /translation="VNCHATSTQVGDVIE"
     gene            complement(15024..15263)
                     /locus_tag="BN6_RS07720"
                     /old_locus_tag="BN6_15730"
     CDS             complement(15024..15263)
                     /NRPS_PKS="Domain: PP-binding (9-75). E-value: 3.2e-19.
                     Score: 61.0. Matches aSDomain:
                     nrpspksdomains_BN6_RS07720_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947996.1"
                     /locus_tag="BN6_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15730"
                     /product="acyl carrier protein"
                     /protein_id="WP_015099009.1"
                     /sec_met_domain="PP-binding (E-value: 4.2e-17, bitscore:
                     61.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.038, bitscore:
                     13.2, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNEDIQKGLADIVEEVAGVEAADVTVDKSFVDDLDIDSLSMVEI
                     AVQAEDKFGVKIPDDELANLKTVGDAVNYIASNA"
     aSDomain        complement(15039..15236)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS07720_PP-binding.1"
                     /evalue="3.20E-19"
                     /label="BN6_RS07720_PP-binding.1"
                     /locus_tag="BN6_RS07720"
                     /protein_end="75"
                     /protein_start="9"
                     /score="61.0"
                     /tool="antismash"
                     /translation="LADIVEEVAGVEAADVTVDKSFVDDLDIDSLSMVEIAVQAEDKFG
                     VKIPDDELANLKTVGDAVNYI"
     misc_feature    15264..15278
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.75"
                     /tool="antismash"
     gene            complement(15328..16305)
                     /locus_tag="BN6_RS07725"
                     /old_locus_tag="BN6_15740"
     CDS             complement(15328..16305)
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /function="3-oxoacyl-[acyl-carrier-protein] synthase III"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099010.1"
                     /locus_tag="BN6_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15740"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_015099010.1"
                     /sec_met_domain="fabH (E-value: 3.3e-106, bitscore: 354.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLTARTGPAGTRILGLGSYQPETIVSNDDLAQTMDTSDEWIRD
                     RVGIANRRFAKPDELLVDMTVAAGAKAIADAGLEPADIEAVLVATCTMPSMIPNAAAQV
                     AYRLGVPAGAAFDLNAACAGFCYGLATASDLVRAGTAKHVLVIGAEKLTDWVNPVDRST
                     AIIFGDGAGAAVVGPSDEPGIGPVAWGSAGEHSEMIQVPDRHSFIFQEGQSVFRWATTQ
                     IAPIALRAVELAGIEVSEVDVFVPHQANLRIIEAIAKRLRAKGAREDLVVARDIVDSGN
                     TSSASIPLALDHMRAAGEVRSGDVALLVGFGAGLSYAGQVVRLP"
     gene            complement(16302..17222)
                     /locus_tag="BN6_RS07730"
                     /old_locus_tag="BN6_15750"
     CDS             complement(16302..17222)
                     /EC_number="2.3.1.39"
                     /GO_function="GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_AT (6-285). E-value: 1.1e-42. Score:
                     138.4. Matches aSDomain:
                     nrpspksdomains_BN6_RS07730_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018331416.1"
                     /locus_tag="BN6_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15750"
                     /product="ACP S-malonyltransferase"
                     /protein_id="WP_041316289.1"
                     /sec_met_domain="PKS_AT (E-value: 1.5e-40, bitscore: 138.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIALLAPGQGSQTPGMFTPWLDVEGAAERVAAWSEATGLDLLRLG
                     TTAEADEIKDTAVTQPLVVALALLAFEELRRRVPLPVDTVVGGHSVGELAAAAIAGVLS
                     TDDAVALAAVRGAEMAAACALAPTGMAAVLGGEQDVVLARLDELGLVGANRNGAGQIVA
                     AGSLDALDKLVENPPERAKIRKLQVAGAFHTEYMAPAEEALRARAATIAVADPALPLLS
                     NADGAVVTSGPDVLNRLISQVTRPVRWDSCQATLGARAVTAVAELPPAGTLTGLAKREL
                     KGTPTLAVKTPDQLDALVELLEASA"
     aSDomain        complement(16368..17204)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS07730_PKS_AT.1"
                     /evalue="1.10E-42"
                     /label="BN6_RS07730_PKS_AT.1"
                     /locus_tag="BN6_RS07730"
                     /protein_end="285"
                     /protein_start="6"
                     /score="138.4"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="PGQGSQTPGMFTPWLDVEGAAERVAAWSEATGLDLLRLGTTAEAD
                     EIKDTAVTQPLVVALALLAFEELRRRVPLPVDTVVGGHSVGELAAAAIAGVLSTDDAVA
                     LAAVRGAEMAAACALAPTGMAAVLGGEQDVVLARLDELGLVGANRNGAGQIVAAGSLDA
                     LDKLVENPPERAKIRKLQVAGAFHTEYMAPAEEALRARAATIAVADPALPLLSNADGAV
                     VTSGPDVLNRLISQVTRPVRWDSCQATLGARAVTAVAELPPAGTLTGLAKRELKGTP"
     CDS_motif       complement(16866..16967)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS07730_0002"
                     /evalue="1.10E-13"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="BN6_RS07730"
                     /protein_end="119"
                     /protein_start="85"
                     /score="43.1"
                     /tool="antismash"
                     /translation="VGGHSVGELAAAAIAGVLSTDDAVALAAVRGAEM"
     CDS_motif       complement(17172..17204)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BN6_RS07730_0001"
                     /evalue="2.80E-03"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="BN6_RS07730"
                     /protein_end="17"
                     /protein_start="6"
                     /score="10.8"
                     /tool="antismash"
                     /translation="PGQGSQTPGMF"
     misc_feature    complement(17232..17243)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.72"
                     /tool="antismash"
     misc_feature    17290..17306
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.9"
                     /tool="antismash"
     gene            complement(17408..18595)
                     /locus_tag="BN6_RS07735"
                     /old_locus_tag="BN6_15760"
     CDS             complement(17408..18595)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099012.1"
                     /locus_tag="BN6_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15760"
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_041316291.1"
                     /transl_table=11
                     /translation="MSGSDGVVPELSRGTLRTLQRASGDLAAASVAEMEERLPWFRRMP
                     ADQRAGVLLLIQSGVAGFVSWLHDPQQAIRLTAEAFRSAPKDLSRWVSLRQTVELVRIA
                     LELFEQLLPKLADGDAERALLTEGVLRYGREIAFSAATSYAAAAEARGAWDARLEALVV
                     DGIVRGDAEESLLSRATALGWDPAAEATVLVGNPPSDDPPAVIFEVRSRAARISRPVLL
                     SVQGSRLVVVLGGETESGDALVRLADAFGAGAVVAGPSVSSLADAHRSASDALSGLRAV
                     VGWPAAPRPVRSLDLLPERALAGDPEAEWQLVDRIARPLEESGGALLETVDAFLEVGGV
                     LEACARRLFVHPNTVRYRLRRVTELTGRNANDPRDALVLRVALSVGRLARARGLW"
     misc_feature    complement(18936..18949)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.08"
                     /tool="antismash"
     misc_feature    complement(18937..18950)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.95"
                     /tool="antismash"
     misc_feature    complement(18944..18953)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.64"
                     /tool="antismash"
     gene            19413..21083
                     /locus_tag="BN6_RS07740"
                     /old_locus_tag="BN6_15770"
     CDS             19413..21083
                     /NRPS_PKS="Domain: Abhydrolase_1 (113-296). E-value:
                     7.5e-20. Score: 63.5. Matches aSDomain:
                     nrpspksdomains_BN6_RS07740_Abhydrolase_1.1"
                     /codon_start=1
                     /function="Predicted hydrolases or acyltransferases
                     (alpha/beta hydrolase superfamily)"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099013.1"
                     /locus_tag="BN6_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15770"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_015099013.1"
                     /sec_met_domain="PF00561 (E-value: 4.6e-26, bitscore: 90.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRHVSAGLVLITALSVQLPASANTAANTAANTAANTAANTAATT
                     TADTAATTTADAPDLTPFTTQQLTWTPCETVLQCADVVLPLDYKNPATDRITVRISRRQ
                     ATDRAARRGILVLNPGGPGGSGLTMPSFLAQSAPAAVYDLIGFDPRGVGASTALNCRTS
                     PEFATPDTRPSDADFPKWAAEARAAEDSCQRSGGAIRPHINTANTARDLDVIRAVLGEE
                     KLSYLGYSYGTYLGAVYGSLFPSRLDRSVLDSAVHPDWVWRGQFRAQAIAMRRNVDQWA
                     EWVAARDRRYSLGKSGSDVMATVERIAARLAANPTPSDTRTTFDAAIGVGTRYRPLWAE
                     LADAVNDLKDPAPPTDGALSPAGTSPLSLMARAAQDELVSGVFNTVVCEVDWPTEIDTY
                     YEDMRIFRDRYPYGYGVVRAAPTTCTYRSFTPPEPPVRLHRDGYPIGVVVQAEGDTQTQ
                     YESGPAMASRLGHSLITVKDEGKHGVYGSSNKCVNTAVNRYLVDGILPGSSSECPGSPR
                     PDETKPGTSGVATVQSFLDERGLLAWTKPGAPRPPRPRP"
     aSDomain        19752..20300
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BN6_RS07740_Abhydrolase_1.1"
                     /evalue="7.50E-20"
                     /label="BN6_RS07740_Abhydrolase_1.1"
                     /locus_tag="BN6_RS07740"
                     /protein_end="296"
                     /protein_start="113"
                     /score="63.5"
                     /tool="antismash"
                     /translation="ILVLNPGGPGGSGLTMPSFLAQSAPAAVYDLIGFDPRGVGASTAL
                     NCRTSPEFATPDTRPSDADFPKWAAEARAAEDSCQRSGGAIRPHINTANTARDLDVIRA
                     VLGEEKLSYLGYSYGTYLGAVYGSLFPSRLDRSVLDSAVHPDWVWRGQFRAQAIAMRRN
                     VDQWAEWVAARDRRYSLGKS"
     gene            21560..22372
                     /locus_tag="BN6_RS07745"
                     /old_locus_tag="BN6_15780"
     CDS             21560..22372
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099014.1"
                     /locus_tag="BN6_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_15780"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_015099014.1"
                     /transl_table=11
                     /translation="MGSQITDGLGQAWAMIATFVPKLLGFLLVLFVGWLIAKALAKGVG
                     FLLKRVGFDRLVEKSGLGGAMAQSPIDASGLIVKIVYYFVLLIALQLAFGVFGTGNAVS
                     ALLNDVIAYLPRIVVAMVLVLVAAAIGKALRGLVTGALGNRPYTKALGGITYGFIVALG
                     VIAALNQLGIAVSVTMPVLITVLATVAGVIVIGVGGGLVRPMQQRWEGWLQRMQQETAG
                     HAPAPRQSQDPVAPPRPTASATARPTSRQGPVDPPTPPAGIQMPQTDR"
ORIGIN
        1 gctgtcccaa tccagtgttt gggcttactg gtccgtatcc atcaagatgt gcgagtgcat
       61 gaaaatcccg ccgaaaaccg cttagccaag gtgatgcgcc gtcagcctgt ccagcagcgg
      121 ggtgccgcca cggtgaccgc cattgtcgac gcgtgcgcgc ggctgctgaa cgagtacgac
      181 tacgacgaca tcaccacagc ccggatcgtc gagctcgccg gcgtgccaat cggctcgttc
      241 taccaatact tcccggacaa gcgttctgtt gtgcacgcct tggcgctgcg cggcatggag
      301 cagtacctca agcgggtcga aacgctgttc aacgaagggc acctcgccgc gaactggcgg
      361 gaagcggtgc agcaagtcgt ggacgtctac ctccgcatgc tggtcgaatt gcccggtttc
      421 gggcgggtcc ggttcagcga cctgttcgac ggccaccacc tcgacgccag cgtcgaccag
      481 tacgaactca tggccgaacg gctccgcgaa ctgttcgtca accgcttcgg cgtccggggg
      541 gacgcgccgg tcgcgctgac gttccggatg gccacccaga ccgccgacgc gatgtacaag
      601 ctggccgaac gggtcgaacc cgccgaacgc accgtcgtcc tccgcaccgc cgacggcgtg
      661 atactccgca tgctgtccgg ggtgttcgac ccggcgtgac cggcgtgctc gacccggcgt
      721 gatcggggtg tccgacccgg cctgaccggg ggcgttcgac ccggcatgac ttgccgcgcc
      781 ggcccgggtg gtgtgggctg gaccggtgag cgacttcgac gtgatcgtga tcggcggcgg
      841 accggtgggc gagaacgccg ccgcccggac cgccgccggg ggcctgaaga ccgcgttggt
      901 ggaagccgaa cgggtcggtg gtgagtgctc gtactgggcc tgcatgccga gcaaggcgtt
      961 gctccggccc ggtcacgcgc tcgccgccgc ccgtcgggtc cccggcgtgc ccgtcggcga
     1021 acggctcgat cccgccgcgg tcctcaagcg gcgcaacggt ttcacgtcgg actgggacga
     1081 ctcgggccag gtggggtggg ccgagggtgc cggtctggag gtcgtgcggg gtcgtgggcg
     1141 gctggtcggc gaacgtcagg tcgaagtcga tggtcgggtg ctgacggcgt cccgcgcggt
     1201 cgtcgtgtgc accggcagcg tgccgcgcat ccccaagctg cccggtctcg cggacgtgtc
     1261 gtactggacg tcgcgggagg ccacctccgc gcaggaggtg ccgacgtcgc tggtggtgct
     1321 cggcggcggc gtggtcggcg tggagatggc gcaggcgtgg gcccggctcg gctcggcggt
     1381 gacgctggtc gtgtccggcg cgcgcccgct gcccaagttc gaggacttcg cgggcgacct
     1441 ggtgctcgac gggctgcgcg aggacggcgt gaccgtgcgc accggcgtca aggccaccgg
     1501 tgtgtccact gtggatggtg acatcgcgtt ggcgctgtcc gacggcacgt cggtcgccgg
     1561 cgcgcacctc ctggtcgcca ccggccggca gcccgccacg ttcgacctgg gcgtcgaggg
     1621 gttcggtttc accgcgggcg acgcgctgcc cgtggacgac accggccgcg tcgacggcgt
     1681 cgactggctc tacgcggcgg gcgacgtcac cggccgcgcc ctgctgaccc accaggggaa
     1741 gtacgccgcc cgcgcggtcg gcacggccat cgtcaccggc gcgaccgacc ccgagccgtg
     1801 gaccgcgccg gtcgccaccg ccgaccacac cgcggtgccg caggtggtgt tcaccgaccc
     1861 cgaggtcgcg tcggtcgggt ggaccgaggc gcaggcgcgc gaggcgggcc tggacatccg
     1921 ggtggtggac ctggacatcg cggtggccgg gtcgtcgctg cacgcggacg gctaccgggg
     1981 caaggcgcgg atgatcgtgg acgagcggcg gcgcaccctg gtcggtgtca cgttcgccgg
     2041 cccggacacc gcggagctgg tgcacgccgc gacgatcgcg atcgtcggcg aggtgaccgt
     2101 ggaccggctg tggcacgcgg tcccggcgta cccgacgatc agcgaggtgt ggctgcggct
     2161 gctggaggcc tacggtctct gaccgccggt agaccgccgc tcacgcaccg agatcagcgg
     2221 tacgccgagt gccgtacgtc ttgtgcccca ttaggtgcca actccgaaat ttcgcggtct
     2281 gcctcattac actgagacaa gtgaccagag gaaccgttgc cctcgcgacc gcggcggtcc
     2341 tctggtgcgc gttcctgatc ggcacgacgt tgacgcccgg cgggcccgag ttcacgccgt
     2401 tcgtggtgca cctgccgggt ttcctggtcg ccccggtggt gttgttcacc ctgctccgcg
     2461 cccggtccaa cgccgtgctc tgcctggctc acgtgccgaa gtcgttgctg ggtctgggtt
     2521 tcgcggtggc ggtcgcgggg tggctgttct cctgcggcgc gctgaccggc cggccgggca
     2581 ccgagatgct gtgcacggtg gcgggcctgg cgatcgtgct gcacgtggcg ttcgggctga
     2641 tcgcggtcgg cctggtccgc accggccgct gaccgccaac ccgaccccgc accactccgt
     2701 accacgctcg acacctgtcc cgaacggcgt agcacccgtc accgcaacgg actaccgcga
     2761 ccagcacgga tcacggcaac cgaaacgccg tgaccgacac cccgcaagcg gctactgggt
     2821 ggagggcagg cgcagcgctt ggtcggcgag tgcggtcaac gccgggtcgg cggggtcgga
     2881 ctcgccttcg gcccacacga cctgggcgat gcggacctgg ttggtcttcg tcgccgtccg
     2941 gatcgccgac cggtcgaacg acaccgggcc gcccggccac gtccggccgt ccttgaccag
     3001 cgcggtcacc ccgccggagc cggccgccga cgccacctgg cgcagctcgc ccgcccgtgc
     3061 cgcgtccggc aggttcagct ccgacaccgc gacgccgacc ttgcggccgt ccaccaccgt
     3121 ctcgtactgc gcccgccgca gctgcatgca catgtgcccg gacaaccaca cctgcacgtc
     3181 gccgaacgcg tgcttcgcgc agtcctcgct ccggtccgcg cccttggggg tgaagttccg
     3241 gccgtccacg accaccgtcg tcggctgcgg tgtggagctc gcggactgcg tcgccgcgga
     3301 ctccccgccg gaggtcagcg tcacgaccag ccccaccacc agcagcaccg cgaccacgcc
     3361 cgccgccgcg tacgggagcc accggggccg gcgcggcgcg ggcggcacct tgggcagcag
     3421 catggtgctg gccgacgcca ggtcggccgc cgcgtccggg aacccctcgg cgcgcaactg
     3481 ccgggtgtcc ggcgggatgc cggtgggcgc gaggacggcc agcagcttgg cggcgtgctc
     3541 ggcggagcac gggcggtcgc tggtggccag ttcacgggcc gccgcgagca gcgtggtggg
     3601 cttggggtgc agcacccgca cgccgcggtt gaggtcgccg gtcggctgca cgacgtgcgc
     3661 cacgtaaggc cccaccgcga ccaccgtcgt caccggcagc ggttcgccgc gcatgtcctg
     3721 gatccgccgg gccacggcgg tggtcgccgc cagcgcctcg gcggccgggc tggtcgcgcc
     3781 gtccgggcgg gtcagcggcc agccgtcgat ccgccactgg ccggccagcg gcgcttccag
     3841 ccgcatcgcg gggtccggca ggtcgacgcc gaccaccacg agcacgccgc gaggcagcac
     3901 gatcaccgcg tcgagggtgc gcgggcagtc cggcggggtc acgccgagca tggccacccc
     3961 gcccagcacg gagtcgccgg tgccccacgt gctcagcgcg gcacgcacgt ccacaccgat
     4021 ctgggtcggc tcggctccga gccggatcag ccgcacaaga tcacaccgtt ccacacggtc
     4081 gaacacggta gcgccgccgg gggtggctgt gcccgtggat cggcggtaga cgcgggtggg
     4141 gttcgacttc accgcgatgg cggtgacccg cgccgaggtc caccggccgg tcgtggtgct
     4201 accggagcgg gcccgcgttg atcacgcgag cgtgacgaag tgatctcgga atgtgacctc
     4261 ttcggagctg tcgcacgcgc tgaggttgca ctttagggtc gaaagtcctg tatctgaccc
     4321 gcccgggtga tgaacgtgct ggttcttctg gcggaccgca ccgccagcgg gcagaatgac
     4381 catgtcggga attcaccgga tcgtccgcgt cgacaggccg taggggaaga cgtccctcgt
     4441 cgagtagcgg aggtcagctg tgagcacccg cagcaccagt ggcgtggtct acgtccactc
     4501 gtcgccgtct gcggtctgtc cgcacgtcga gtgggccatc tcgggcaccc tcggtgagcg
     4561 agcggacctg aagtgggcgg cacagcccgc cgctccgggc cagttgcgcg ccgagtgcgc
     4621 ctgggacggg gacgccggta ccggcgcccg gctggtggcc gcgctgcgcg cgtggccgat
     4681 ggtgaggttc gaggtcaccg aggacccgag ccccggagtc gacggcgtcc gctactgctt
     4741 cgcgcccgtg ttgggcctgt ggcacgcccg gaccagcgcg aacggcgaca tcgtcgtgtc
     4801 cgaggaccag ctgcgcgcgc tggccgcgcg cagccggggc ggcgagtcgt tcgcccacgg
     4861 cgtcgacgag atcctgggcg cggcctggga cgacgcgctg gaaccgttcc gccgggcggg
     4921 cgacggcgcg ccggtcacct ggctgcaccg cgtcggctga cccgaccgcg tccaccccgg
     4981 acgcggtcgg acccgacccg ccccaccggg tcccggccga ccacgtcccg agccaccacg
     5041 tcccgagcca ccatgtcccg atccgccgaa cccccgctgc cggctcccga ccgacaggat
     5101 cccgaccagc ttccgaccga ccagcttccg actgggtcgt cccgcccgta ccggcacgcg
     5161 gcccgccgcc gcgcgcccgg aacccgccgc gctcgaccac ccggtacgcg ccgggcccac
     5221 tgcatcccgg ggttcgtcct cagcggaccc agacgtgcga gtacacccgg taggccgggg
     5281 gccgccggtc ggcgagccgg ccgagcacca ggtacccgag gtcgccctcc gcggtcttca
     5341 cgcaggccac cgtcaggtcg tcggtgaagt ccccgtcggc gaacgactcg cgccagtcgc
     5401 cggtctcgcc gcactccttc tcgccgggca ggctctgggc gtcgaggttg cgccacaggt
     5461 cccggacgcc gtagttctcg atccgcccga tccgcgcccc gttgatcgcc ttcagctcgc
     5521 cgctgatgtg gttgtaggcc aggtccgagc ggtacccgga ccgcgagcgc tccaggtcga
     5581 cctcggtgtc ctgcccggtg gcgtggaact tgaactcctc gatgtcgacc cgcgcggggc
     5641 cgggcgtccc ggtcaccggg gccgggccgt cgtcggtcac cttgatcctg gtgccgggcg
     5701 cggtgaacag cacctgccgc cgggtgtcga tgtgctggac gaccttgccg tcgatggcga
     5761 cccgcagctt gcggccggtg tggatggtgt accggtcgca ccgggtcggc gtctgctcgg
     5821 cggggcagat gatcacctcg cgctcgtcgg ccggcggcgg gggcagctcg cggtcctcct
     5881 cgtcggtgac ggtgtcctcg tcgagccgct ggttcacgcc gaccttcacc ttgccgaacg
     5941 gtgtcacgat ctccgcgctg accgccaccg agatctcgcc cttggtgttg atcgtaaaag
     6001 tgatgggcac gatcggcggc tggaagccga tgtggccgat cggggctttt ccgccctttt
     6061 cggagtcccc gggcagggcg ggcaggccgt tctcgccggg caacggcggt gcgacgtctc
     6121 cgatctcgtc ggtcttcccg caggcagtga ccgtggtggc gcagacggcg agcaccacga
     6181 ggggcttgat ccaggaatgc atgggcagtg cctcgacgtg tccggagggg atggctgccc
     6241 acaggttaga caatttcttc ccgataccac cggagaaacc ccggtcaggc ctgccgtgtc
     6301 agccgaaaga aatccccatt aatcgtgttc tccgatttct gcggtgtcac gcggcggtgg
     6361 ccggctgcca ggccgccatc aggtccgcgt aggtcgggga ctccgccatc agccgctcgt
     6421 gcgtcccgag cagcggcggc ccgccgtcca tcaccagcac ctgcccggcc cgcagcgccg
     6481 acgacagccg gtgcgcgatc accaccagga tgccgtcccg cgccgcgaac gcccgctcca
     6541 cgacggcctc cgccgccggg tccaggttgg acgtcgcctc gtccaggacc accacgtccg
     6601 ccgggcacgc gtagacccgc gccaccgcca gcaactgggc ctcgcccgcg gacaggctgc
     6661 cgcccgcgtg gcccaccgac ccgtcgagcc cgcccaaccg cgccaccacg tccgccgcgc
     6721 ccaccgccgt caccgcggcc agcaggtcgt cgtcgccggc cgtcggcgcg aacagcgcca
     6781 ggttctcccg cacggtcccg gtgaacaggt aggtctcctg cggcaccagc gcgatccgcg
     6841 cgtgccgcac gtccggccgc acctcgcgca ccggggcccc gccgagcagc accgtcccgg
     6901 cctgcggggc gaccagcccg gtgaccagcc cggccagcgt cgacttgccg atcccgctgg
     6961 gccccaccac ggccaggtgc gcgccgcggg ccaggtccag gtcgaggtcg cgcaccacgg
     7021 gctcggcgtg ctcgccccac ccgaacgtga cgccgcgcag caccaccccg ccctcgcccg
     7081 gcaccaggtc gccggcctcc tcgggcacct cgggcgcggc ctcggcgagc cgccgcagcg
     7141 ccaccgccag ccgcagcacc accgtgctcg tggtgtccgc gagccgccgc agcgcgggct
     7201 gcacgctggt gctcaggtag acgacggcgg ccagcacctc gccggcggtg agcgtgccgg
     7261 cggcgaccat gccgggcgtg agcaccagca gcagcaccag cggcaggaac ccgccgaccg
     7321 cgatcacgat gccgcgcagc gccgtcgacc acgccatccg cacggtggcc cgcgcctgcc
     7381 ggtcgacctg ccgcccgacg tcctcggcgg cccgggaccg cccgccgcac gcgacgacgt
     7441 cccgcatccc gagcagcacc gtgccggccg cctcggccgc gtcctcgtcg gccatcacca
     7501 gcgcccgctg cccgcgtgcc agcgacggca gcagcaggcc gaacagcacc agcgccgcca
     7561 ccacgggcag caccaccagc cacgccagcg gggacaccgc ggtggccagg ccgaccagcg
     7621 cggcggtggt cgtcacgagc agcgcgcggg cctggatgag cagtccggcg gtcgcgtcgc
     7681 gcaccacctc gacgtgccgg gtgatccggg cgaccgcgct cgcgtccggc tgccggcggt
     7741 gcgaccggcc gtcgcgcagg acgccccgca cgatcgcggt gaccagcccg tcccgcaacg
     7801 gttccaccac gtcgccgagc cgggtgaaca cctgccgcag cccgaacccg ccgagcaccg
     7861 ccagcaccgc gaacgccacc agccacgcca cgccggtccg cacgtcgccg accgcgaacc
     7921 cgcggtccac ggccagcccg accagccggc cgcccagcag cgccggcacg ccctccagca
     7981 ccgaccagcc cagcagcgcc agcaccgcgc gccgccgccc ggccaacgcc cgcaggtaag
     8041 gacccatcag ccgaacaccg cccggtactc cgcgttctcc cacagcgaca ggtgcgaggc
     8101 catcgcgcgc acccggccgt cttccagcca caccacggcg tccgcccggc gcgcggtcgc
     8161 ggcccggtgc gtcacaacca cccgggtccg gcccggcagc gccgaggcga tcgctcgctc
     8221 gacagcggac tcggtgaccg tgtccaggct ggccgtcgcg tcgtcgagca ccagcacctg
     8281 cgggtcgcgg accaccgccc gcgccagccc gagccgttgc gcctcaccgc cggacagcgg
     8341 cgtgtcggcc atcggcgtgt cgtagccgtc gggcagtcgc accaccacgt cgtgcacccg
     8401 caccgcccgg cacgcctcct cgacctccgg ccggcccagc gaggtcccgt aggccacggt
     8461 gtccgcgacg gtcgcgccga gcagcgccgg ccgttcgaac gcgtagccga ccgacccgcc
     8521 gcgcgcgacc cgcccggccg agggcgcggt cagcccgccg atcaccgccg ccagcgccga
     8581 cttgcccgag ccggagcgcc cgaccaccgc caggaacatc ccggagggca ccagcaggtc
     8641 cacgtcgtgc agggcgtccg gcacgcacac cccgcgcagc tccaccgcgc cgggcggcgc
     8701 gtacccgggg gcgcccgccg cgaccggctc ctgcgccagc acctcgtcga tccgcccggc
     8761 cgacgcgcgc gcccgctgca cggcggtcag cacggccgcc tggccgacca ccgtcatgcc
     8821 cagggccgcg taggccatgg cggccagcac gtcaccgatg ctcaaccgcc cggccaccac
     8881 gccgaacccg gccgcggtca gcaccgcgag ctccacggcg ggcagcagca gaccggcccg
     8941 ccagatcatc ttcgcctggg tgcgccacat cccgaccccg gccgcggcga gccggggcag
     9001 cggccgcagc acgcggtccg cctcctggtc ggcccgaccg gacgcggcga tcgtgcgcag
     9061 cccgcccacg gcgtccagca gccgcgccga cagctcgccg gacacctcct ggtaggtggc
     9121 cacgtcgtcg gcggtcagcc gcaggtgcga gcgcaccagc agcagcgcca gcggcacgct
     9181 cagcaggaac accgccgcca gccgccagtc cagcagcgtc aacgccacca ccgcgccgcc
     9241 cgcggtcatc acggtgatcc ccaggttgac cagcagcacc gcgaagttcc cggcgatcgc
     9301 gctgtccccg gtcagccggc tcaccgcgtc accggcctcg aaccggcccg ggtgcccgag
     9361 cccgaccagc ttgccgatca ccttgcggcg caggaacgcg gtgccgcgcg cggcgatcgc
     9421 cgccgccagc accacgccga tcgcgtcgcc caccacctcc acgcccacca ggccggccag
     9481 ccacagcacg gtcccggggt cgagccgccc gcccagcgcc atgtccaccg cgcccgcgag
     9541 cgcggtcggc agcagcagcc cggcggtggt ggccagcagg gcgttgccgg ccagcagcag
     9601 ccagcgcgga tcgcgcagga cgaccgttct cagcagcatt cggtgctcca ggcgggcggg
     9661 gcgcatcatg ggcgagggcc cgacgccggc caccccgggt gtgagccggg aggccgtcgc
     9721 cggaccctcg tgggaccggg tgagcggcgc acttcgcctg cgccgctcac ctcgttctcg
     9781 tccgcgggcg agatcagcag agcagcaggc tcgcggagga gtggctgcac gggagcagca
     9841 gggagacgct ggacgcggtc gtgctgccgc caccgccgct gctgccgccg ctggccatcg
     9901 cgttggactg gacctcgggg gtgtccatgt cctgaaggtc gaggatgaac tccatgtcga
     9961 ctccttggtg ctcgtcgggg ggaactgtgg gggaaacggg ttactgcaac cggcccgcga
    10021 gggccggggc tgtgaggaac ggcagtgcgg gcacgccgtc cacggcggac gcgagcgcga
    10081 gcagcacgcc cgccccgccg gtgttgaggt ccatcgacag ccggcgcagc tggacgcccg
    10141 ggaacgccag cccttcctgg tagggcacgg cgtgccaggc cagcgccgac aggtgccggt
    10201 cgaccgcctc gcgggtcccg cccgcctggg cgagcgtggc cagcaggccc gcccggccca
    10261 ccatgaacgc gggctggatg acgaactcgc aggtcagccc ggagaccagt tcgggcagcc
    10321 gggccgagca cgcggcgtcc ggcgcgaccc gggcgaactc gtcgagcgcc agcgcgatcc
    10381 cggcgctgcc gatgcccacg tagggcaggg tgcgcagggt gccgtcgcgg acctgggtcg
    10441 agccgtccag cgcggtcatg cactcggcga ggtcgcgttc cagcgcgcgc tcggcgtggt
    10501 cgagccaccg ccgttcgccg gtcagctcgt gcagccgggt gaacagcagc gccgggccgg
    10561 accagccgtg cagcaggccc gcgcgggcct tgtcgccggg cggcggcgcg tcggcgagca
    10621 tcccgaccag ccggtcgccc aggtccagcg cccggtcggc gaacgactcg tcgtcccggc
    10681 gcaccgcgaa gtgcagcagg ttcagcgcga ccccggacag gcccgcgttg aggccgtggt
    10741 ccttggtgtc gggcagcagc tcggcgtact cgcggaccag ctcgtcggcc tcgtcgtggt
    10801 agccgaagtt ctccagcacg tgggcgatcc cgtgcgcgcc ggtgtagaaa ccgggctcct
    10861 tcggcgggtc gcggcgcagc gagtccagca gccaccgctc gtgctcgggg aaccggccct
    10921 cgccggcgac gtcgagcgcg tgcagcacac cggccgcccc gtaggcgaag cacgcgccgc
    10981 ccacctcgaa ctgctccacg tcaccgggga acagccggtc gtggcgctgc ggcgtggcgc
    11041 tggccaggat cgccgcggcg atcgacttgc gcacgaccgc ccagtccggc gtcggctcgt
    11101 ccagcgccgt cgacacccgc accggcgggt cgacgcgcgg cgtgagcacc tccacgatcc
    11161 ggtcgcagta gtcgtccggc aggccgaacc gccggcggat gaactccacg tggtggcgca
    11221 gcttcgcggg ggacagctcg atcaccgcgt tgagcggcag gaacacgtac agccgcagcg
    11281 cggccagcgc gtagtcgtcg atctcgaacc cggagcggtc cggcggggcc tggaaaccgg
    11341 gggagcccag cgttggcctg cggtcctcct cgacccggaa cgcgagctcg aagtcgatca
    11401 gcgacaccgc gtcgtcgtcg tccacgagca cgttcaacgg gtgcaggtcg ctgaacacca
    11461 cgccgcgcgc gtgcacgtcg gccacgatcc gctcgacgtc ggccacgatc gccagcgccc
    11521 gcgcggtgta ctcggacagg tcgccgacgt cgtagtgggt caacgggtag tgctggccca
    11581 gccactggcc gatcggccgg cccggcaccg gttgcatcgc gaagaactcg tgctcccacg
    11641 cgctgaacag ctcgtgggcc gcgggcaccc cgggcacgcc ggacagcagg gtgaggatgt
    11701 cgtgctcgcg gcgcagccgg gccaccgcgt cgacgttgtc ccggtccagc ccggcgtgcg
    11761 gtcgggcctc cttcagcacc acgtccgcgc cgtcggactt gcgggtcgcc cggtacacgc
    11821 cgccgccgtt ggagaagtgc agcgactgcg tcacccggta ggggaacgag tcggcgtcac
    11881 cgcccttgcg ggccgcgagg tgttcttcca ggcacttcgg cagggtgatc cagtcgggca
    11941 cccagaaggt cggtttgcgc tggtcgggaa ccagttcgcc ggtcgcgccc tcgatcgcca
    12001 ggacgcgtct gccgtcgact tccagccact gctcgacaaa gccgccgtaa cgcacgaaca
    12061 acggtcccgc ggcgtaccgg agatcgctca ggatgtacgc gccgggctga cccgcgagca
    12121 gttcgtcgag ctcgcgcagg gtcttttcca actgcgcctc gtcggccggg tagatggtga
    12181 tcagcttgcc gctcgcctcg cgcggggcgt atttcgagtt gcgggccagc acgatcgacc
    12241 gggtgcgcag gtacttgaac gggatgcgcc gcgcgaccag gtgctcgtag caggccagga
    12301 gcacctcgcc ggcgttgccg acggtggccg agacgtggat cttccagccc tggcggggca
    12361 gcaccgcgcc ggccggctgg aggtagcgcc agatcgtgag atcggcccgc gcccagtccg
    12421 ccggaagctc cgggagcacc tgcgaaaaat catcggcagc gatttccgtg gagctttgca
    12481 cgtcgtagaa gagacggtcc gcgaagcagt aagcctcata gcggagatcc accggaattc
    12541 gcctccctgt aatttgtggg accggcatat tcccgcatgt gagtgcactg gaggccaatc
    12601 cgccagatcg gggagccgac taggccgtcc gtgctgcccg agacggcccg aacaggtact
    12661 ttgcgttgtg tcggatgcag ccgaaccacc cgtttgccag gtttgccgct gggctattcg
    12721 gagtccttgg gggagcgccg ctaaacggca cggaatcgtt ctgctttccc cgtgcggccg
    12781 gcctgcggaa tcggctgaac ttccgctgtt ttgcggttcc ggtcacccgc cgtggtggtc
    12841 taggcctatc agggggttac tcggctatca ggtgtggtcg gcgtccgatg gggtgtggat
    12901 caggggccga aattcgggtt taacccattg ttcaccaaac tcgcgcccca tcccgaccgc
    12961 acggatcggg tttcgccctg ggctgatcgg gtggtcaatc atgcgttcgg ccgcatatgg
    13021 cacgctgata ggtgtgtcgt cccggctgct gctgcccgcg gtgctggtgg tcgccgcgct
    13081 gaccgcggcc accggcgcac tggcccgcga ggtctaccaa cgccccgcgc aggcggtcgg
    13141 cgaccgcatc gccctgccgt ccgactcgtc ccccgtgccg cgcgccgacc agcccggcag
    13201 ccccaccgtg cagcgcagcc cggacgccgc cctgcacccg gacggcgaac gcgtccgagc
    13261 cctgctccag cgctacttcg acgccatcaa cgcccgcgac tacgaccagt gggccaccac
    13321 cgtcaccacc gaacgggtcg cccgcacccc gcgcgcccgc tgggagtccg actacgagac
    13381 cacccgcaac ggcaccatcc tggtgcaccg cgtggaaacc gtgtcaccga cccgggtgcg
    13441 cgtgctgatg acgttcgtca gcacccaggc cctggccaag gcccccgccg acctgcaagc
    13501 cgactgcatc cgctggcggg tcgtctaccc cgtccaagag gaagcaggca acctgcgcgt
    13561 cgacttcggc accgagggct ccagctccca gttcaccgcc tgctgacccc aagaacccag
    13621 ccgacatccc gcccgacgcc caccacccag acctgcggca ccttcccaga cgaccggatc
    13681 atcgccgaca ccatcaggcc catcaggccc gtccggtcca tccggcaact ccgcaaagcc
    13741 gtacgcccga ccgaccctca ggtcgctcgg gcgctggtgg acagggacag atcagccgtt
    13801 ggtgaagacc agggacacgt tgtgcccgcc gaacccgaac gagttgttca ccgccgcgac
    13861 caggtcgatc ttgcgcggtt cgccggtgac cacctccaac tgcaccttcg ggtcctggtt
    13921 ctccaggttc agcgtcggcg gcacgacgcc gtcgcgcacc gagagcagcg tggtgatcgc
    13981 ctccaccgcg ccggacgcgc cgagcaggtg accgtggttg cccttcggcg cggtcagcac
    14041 cgggtggtcg ccgatcgccc ggcgcacggc cagcggctcg atcacgtcgc ccacctgggt
    14101 ggacgtggcg tggcagttga cgtggcccac gtcggacgcg tcgacacccg cgttgcgcag
    14161 cgccgtcgcg atcgcccgcg actggcccag gccctccggg tcggccgccg tgatgtggtg
    14221 gccgtcggag ctggtgccga tgcccgcgag cgtgccgtag acccgggcac cgcgggcgcg
    14281 ggcgaagtcg ccgcgctcca gcaccaggat cccggcgccc tcgccgagca cgaagccgtc
    14341 ccggttgacg tcgaacgggc gggaggcccg ctcgggctcg tcgttgcggg tgctcatggt
    14401 ccgggcctgg atgaagcccg ccatggtgat cgtggtgatg cacgcctccg cgccgcccgc
    14461 cacgaccacg tcggcctcgc cggcgcgcag catccgccac gcccaggcca gggcctcggc
    14521 gccggacgcg cacgccgaga ccggggcgtg caccccggcc cgcgccttca ggtccaggcc
    14581 gacgtgcgcg gccgggccgt tgggcatgag catgggcacg gtcagcgggg acaccttgcg
    14641 cagccccgag gcctcgatca ggtcgtcctg gtccagcagc gtcatcgcgc cgccgatgcc
    14701 ggtgccgacg accacgccga gccgctcggg ctcgaccccg tcgtcaccga gcccggagtc
    14761 cgcccacgcc tggcgggcgg cgaccaccgc gacctgctcg cagcggtcca gtcggcgcgc
    14821 ctcgacgcgc ggcaggatct cggtcggttc gaccgccagc cgcgcggcga tccgcacggg
    14881 cagctcgaac cgctccaccc agtccgtcac cagcggcttc acgccactgc ggccggcgag
    14941 cagagcatcc caggtggagg cgacgtcgcc accgagcggg gtggtggcac ccagcccggt
    15001 gacgacgacg tcgttgacag tggtcatgcg ttgctggcga tgtagttcac cgcatcgccc
    15061 acggtcttga ggttggccag ctcgtcgtcc gggatcttca cgccgaactt gtcctcggcc
    15121 tgcacggcga tctccaccat ggacagcgag tcgatgtcca ggtcgtccac aaaggacttg
    15181 tccaccgtca cgtcggccgc ctcgacaccg gcgacctcct cgacgatgtc ggcgagcccc
    15241 ttctggatgt cctcgttgct cactgaaaat cccttccttc ttcttgcttc cgccggccgg
    15301 gctgtcccac cggagtctgg tgtcgggtca cggcagtcgg acgacctgtc ccgcgtagga
    15361 caggccggct ccgaagccga cgagcagggc gacgtccccg ctgcgcacct cgcccgccgc
    15421 gcgcatgtgg tccagcgcga gcgggatgga ggcggaggag gtgttgccgg agtccacgat
    15481 gtcacgtgcg accacgaggt cttcacgcgc acccttggcg cgcaaccgct tcgcgatggc
    15541 ctcgatgatc cgcaggttcg cctggtgcgg cacgaagacg tccacttcgg acacctcgat
    15601 gccggccagc tccacggccc gcagggcgat cggcgcgatc tgcgtggtgg cccagcggaa
    15661 gaccgactgg ccctcctgga agatgaacga gtgccggtcg ggcacctgga tcatctccga
    15721 gtgctcaccg gcgctgcccc acgcgaccgg cccgatgccg ggttcgtcgg acggcccgac
    15781 gaccgccgcg cccgccccgt cgccgaagat gatcgcggtg gaccggtcga ccgggttcac
    15841 ccagtcggtg agcttctccg cgccgatcac cagcacgtgc ttcgcggtgc cggcgcggac
    15901 caggtcggag gccgtggcca ggccgtagca gaagcccgcg cacgcggcgt tgaggtcgaa
    15961 cgcggcaccg gccggcacgc cgagccggta ggcgacctgc gccgccgcgt tcgggatcat
    16021 cgacggcatg gtgcaggtcg cgaccagcac cgcctcgatg tcggcgggtt cgaggcccgc
    16081 gtccgcgatg gccttcgccc cggccgcgac cgtcatgtcg accaggagct cgtcgggctt
    16141 ggcgaaccgc cggttggcga tcccgacgcg gtcccggatc cactcgtcgg aggtgtccat
    16201 ggtctgcgcg aggtcgtcgt tgctgacgat ggtctcgggc tggtagctgc ccagccccag
    16261 gatgcgggtg ccggcgggcc cggtgcgggc ggtgagggag gtcatgcgga cgcctccagc
    16321 agctccacga gcgcgtcgag ctggtccggg gtcttcactg ccaacgtggg ggtgcccttc
    16381 agttcgcgct tcgccaggcc ggtcaacgtg cccgcgggcg gcagttcggc caccgcggtc
    16441 acggcgcgcg cgcccagcgt cgcctggcag gagtcccacc gcacggggcg ggtcacctgg
    16501 gagatgagtc ggttcagcac gtcggggccg gaggtcacca cggcgccgtc ggcgttggag
    16561 agcagcggca gcgccgggtc ggccaccgcg atcgtggcgg cacgggcgcg cagcgcctcc
    16621 tcggcgggtg ccatgtactc ggtgtggaac gcacccgcga cctggagctt gcggatcttc
    16681 gcccgctccg gggggttctc gaccagcttg tccagcgcgt ccagcgaccc ggcggccacg
    16741 atctgccccg cgccgttgcg gttcgcgccg accaggccca gctcgtcgag ccgggccagc
    16801 accacgtcct gctcgccgcc gagcacggcg gccatgccgg tcggcgcgag cgcgcaggcg
    16861 gcggccatct cggccccccg cacggcggcc agcgccacgg cgtcgtcggt gctcagcacg
    16921 ccggcgatgg ccgcggccgc gagctcgccg acggagtgcc cgcccaccac cgtgtcgacg
    16981 ggaagcggaa cccggcggcg cagctcctcg aacgcgagca gtgccagcgc cacgaccagc
    17041 ggctgggtga cggcggtgtc cttgatctcg tcggcctccg cggtggtgcc cagccgcagc
    17101 aggtccagtc cggtcgcctc ggaccaggcc gcgacacgct cggcggcccc ctcgacgtcg
    17161 agccaggggg tgaacatgcc gggcgtctgg gacccctgtc cgggggcgag gagcgcgatc
    17221 acccgctcac tgaacacgtt ttcggcggtc tcacgggatg ccgccactga cgaaacgagc
    17281 gggcaacgtt tgtagggtct ctacaaacgt gactcaaaga tgaacgtcga acgacgtcgc
    17341 gtgttgtggg gcacggccca tccggggcca aatgggacgt gcgtcgtcca tcacacctga
    17401 tcgagggtca ccacaacccg cgagcccgcg ccaggcgtcc cacggacagg gccacgcgga
    17461 gcaccagagc gtcacggggg tcgttggcgt tcctcccggt gagctcggtc acccggcgaa
    17521 gccggtaacg aaccgtgttc gggtgcacga acaggcgccg cgcgcaggcc tccagcacac
    17581 cccccacctc caggaaggcg tccacggtct ccagcagcgc cccgcccgac tcctccaggg
    17641 ggcgggcgat ccggtcgacc agctgccact ccgcctccgg gtcgcccgcc aacgcccgtt
    17701 ccggcagcag gtccaaggac cggaccggtc ggggggcggc gggccacccg acgacggcac
    17761 gcagcccgga cagcgcgtca ctggcgctgc ggtgggcgtc cgcgagactc gacaccgacg
    17821 gcccggcgac caccgccccg gccccgaacg cgtcggccag gcgcaccagc gcgtcaccgg
    17881 actcggtctc cccgccgagc accaccacga gccgggagcc ctgcacgctc aacagcaccg
    17941 gtcgggagat ccgggcggcc cggctgcgaa cctcgaagat gaccgccggc gggtcgtcgg
    18001 acggcggatt gccgaccagg acggtcgcct ccgcggccgg gtcccacccc aacgccgtgg
    18061 cgcgggacaa caacgactcc tcggcgtccc cacgcacgat cccgtcgacc accagggctt
    18121 cgagccgggc atcccaagcc ccccgggcct ccgccgccgc cgcataggac gtagccgcgg
    18181 aaaaagcgat ctcccgcccg tagcgcagca caccctcggt caacaaagcc cgctcggcat
    18241 ccccgtcggc caatttcggc aacaactgct cgaacaactc cagggcgatc cggaccaact
    18301 cgacggtctg ccgcagactc acccaccggg aaagatcctt gggcgcggac cggaacgcct
    18361 cggcggtcag ccgaatggcc tgctggggat cgtgcaacca ggaaacgaac ccggccaccc
    18421 cactctggat gagcaacaaa accccggccc gctgatcggc gggcatccgc cggaaccagg
    18481 gcagccgctc ctccatctcg gcaacactgg ccgccgccag atccccggaa gcccgctgca
    18541 aagtccgcaa cgtcccccgg gacaactccg gcaccacccc gtcagacccg ctcatgccca
    18601 ccacgatcgc acgagccacc ccaccccctc ccgccaccac ctacaacacc ccccgacgag
    18661 cacaaacccc cacaccccag gcgacacaaa cccccgcacc ccaggcgagc acaaacccct
    18721 acacccccaa ggcaagccca caccacgcaa atcccaccag cgcgtcgtgt tctccccgta
    18781 tggcctgcgc gcagcgaacc gcgcttgagc aggtagtgca agcacgcttt tcgcttgcac
    18841 tacctgctca agggtggttg tctcccgacc aggccatacg gggagaacac gacgcttttc
    18901 ctcccccggc ggcctgccca gcggcgagcg tcgcttttcg ctttcaaaaa ccaaaccccg
    18961 gcctctggcc cccaacacca ttatcccaca acaccccgac actcaccctc tcctctcccc
    19021 gcccccgcct ccgtccccgc ctggcccgct ctccgccccc gcgctcccgc ccgctcccac
    19081 ccggccccgc gcttcagcca gcttcgccgc gttccgccgc gcttcgcccc acgcccgtgc
    19141 tccagccccg taaacggcga actgcatccg aaacgggcga actgcgtccg tgacgacatg
    19201 tcgcacctgc gacccgtgac cgtgaacggc gaatacgaaa cgcaacggca aaccgcgacg
    19261 gcgacgccac cgtgcacggt gatcatgggt gtgactgggc accgagtcgg tagtcgccaa
    19321 gctgcccact ccaacgagtg acacaccctg actccccacc ctcaaccgtc ctaccttcgg
    19381 gtggccatcc gccatcaccc gggaggttcg ccgtgcgcag gcacgtgtca gccggcttgg
    19441 tcctaatcac cgcactgtcc gtccaactcc ccgcatccgc caacaccgcc gccaacaccg
    19501 ccgccaacac cgccgccaac accgccgcca acaccgccgc taccaccacc gccgacaccg
    19561 ccgctaccac caccgccgac gcgcccgacc tgacaccgtt caccacccag caactgacct
    19621 ggaccccctg cgagaccgtc ctccaatgcg ccgacgtggt cctcccgctc gactacaaga
    19681 accccgccac cgaccgcatc accgtgcgca tcagccgccg gcaggccacc gaccgggccg
    19741 cccggcgcgg catcctcgtg ctcaaccccg gtggtccggg tggttccggg ctcacgatgc
    19801 cgtcgttcct ggcccagtcc gcacccgccg ccgtctacga cctgatcggg ttcgacccgc
    19861 gcggtgtcgg tgcgtcgacc gctctcaact gccgcacgtc accggagttc gcgacgcccg
    19921 acacccggcc ttccgacgcc gacttcccga agtgggccgc cgaggcgcgg gccgcggagg
    19981 actcgtgcca acggtcgggc ggcgcgatcc ggccgcacat caacaccgcc aacaccgcgc
    20041 gcgacctgga cgtcatccgc gcggtcctgg gggaggagaa gctcagctac ctgggctact
    20101 cgtacggcac ctacctcggc gcggtctacg gcagcctgtt cccgagccgg ctggaccgca
    20161 gcgtcctgga ctccgccgtc caccccgact gggtgtggcg cggccagttc cgcgcccagg
    20221 cgatcgccat gcgccgcaac gtcgaccagt gggccgagtg ggtcgccgcc cgcgaccgcc
    20281 ggtactccct gggcaagtcc ggctccgacg tgatggccac cgtcgaacgg atcgccgccc
    20341 ggctggccgc caacccgacc cccagcgaca cccgcaccac cttcgacgcc gcgatcggcg
    20401 tcggcacgcg ctaccgcccg ctgtgggccg agctcgccga cgccgtcaac gacctcaagg
    20461 accccgcccc gcccaccgac ggcgcgcttt cccccgccgg cacctcgccc ctctccctga
    20521 tggcgcgtgc cgcacaggac gaactggtct ccggcgtgtt caacaccgtc gtctgcgagg
    20581 tcgactggcc gaccgagatc gacacctact acgaggacat gcggatcttc cgcgaccgtt
    20641 acccgtacgg gtacggggtg gtccgcgcgg cacccacgac gtgcacgtac cgttccttca
    20701 ccccgcccga gccgcccgtc cggctccacc gcgacgggta cccgatcggg gtggtggtgc
    20761 aggcggaggg tgacacgcag acccagtacg agagcggtcc ggcgatggcg tcccggctgg
    20821 gccacagcct gatcaccgtc aaggacgagg gcaagcacgg cgtctacggc agcagcaaca
    20881 agtgcgtcaa caccgccgtg aaccgctacc tggtggacgg catcctcccg ggcagcagtt
    20941 ccgagtgccc cggctcgccc cgtcccgacg aaaccaagcc cggcacgtcc ggggtcgcca
    21001 ccgtccagtc ctttctggac gaacgcggcc tgctcgcgtg gaccaaacca ggcgcgcccc
    21061 gcccgccgcg cccccgcccc tgaccgtcgt cccggcgcgc ccgcccggtc gccgcatccc
    21121 ggcgaccggg cttcgccctc cagggcttcg cccgccaggc atcggacccg gccccgcccg
    21181 ccaaacacag caccgggcct cgcccgccag gaaacgcagc ggctccgccc accagacaag
    21241 gcaccggctc gcccgccagg caagcgatcg gggctccggc cggcccagcg agccgccgcg
    21301 cgaagcccgg cgacccctgc ggcgccgtgg cggatcgggc cgccgccgct cgtgccccga
    21361 aaccggaaac gcccgacgcg ctagaagcgc atcgggcgtt tccctctccc cggtccccac
    21421 cggtgattcc actctggact gtcccggcga ttcgcgccac gtcagtcact ctttcgtgcc
    21481 actgcttcag gttgccgggt gatgccgcct gggaaacgat ctcgtcaagc aacatcgaac
    21541 gactttgagg aggggcgtcg tgggctccca gatcaccgat gggctcgggc aggcgtgggc
    21601 gatgatcgcc acgttcgtac cgaagctcct cggcttcctg ctggtgctgt tcgtgggctg
    21661 gctcatcgcg aaggcgctcg ccaagggagt cgggttcctg ttgaagcggg tgggcttcga
    21721 ccgcctggtg gagaagtcgg gcctgggcgg cgccatggcc cagtcgccga tcgacgcgtc
    21781 cggcctgatc gtcaagatcg tctactactt cgtgctgctg atcgcgctgc agctcgcgtt
    21841 cggcgtgttc ggcaccggca acgcggtgag cgccctgctc aacgacgtga tcgcgtacct
    21901 gccgcggatc gtcgtggcga tggtgctcgt gctggtcgcc gcggcgatcg gcaaggcgct
    21961 gcgcggcctg gtcaccggcg cgctcggcaa ccggccgtac accaaggcgc tcggcggcat
    22021 cacctacggc ttcatcgtcg cgctcggcgt gatcgccgcg ctgaaccagc tcggcatcgc
    22081 cgtctcggtc accatgccgg tgctgatcac cgtgctggcc acggtggccg gcgtcatcgt
    22141 gatcggtgtc ggcggcggcc tggtgcggcc gatgcagcag cggtgggagg gctggctcca
    22201 gcggatgcag caggagacgg ccggccacgc ccccgcgccg cgccagtcgc aggacccggt
    22261 ggcaccgccc cgtccgacgg cctccgcgac ggcccggccg acctcccgcc agggcccggt
    22321 cgacccgccg accccgcccg ccggcatcca gatgccgcag acggaccgct gatccgcccg
    22381 tccgcgaagt acacgaacag ttgaacaagg agccccgccc atcccgggcg gggctccttg
    22441 ttcaacgact ggccgacccc gaactccccg ctctcgctct tcgcgaccgg cggatgtccg
    22501 atcgacggat cagtccacgg tcttcagcac gt
//
