LOCUS       NC_019673              22046 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Saccharothrix espanaensis DSM 44229, complete sequence.
ACCESSION   NC_019673
VERSION     NC_019673.1
KEYWORDS    RefSeq; complete genome.
SOURCE      Saccharothrix espanaensis DSM 44229
  ORGANISM  Saccharothrix espanaensis DSM 44229
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Saccharothrix.
REFERENCE   1
  AUTHORS   Strobel,T., Al-Dilaimi,A., Blom,J., Gessner,A., Kalinowski,J.,
            Luzhetska,M., Puhler,A., Szczepanowski,R., Bechthold,A. and
            Ruckert,C.
  TITLE     Complete genome sequence of Saccharothrix espanaensis DSM 44229(T)
            and comparison to the other completely sequenced Pseudonocardiaceae
  JOURNAL   BMC Genomics 13, 465 (2012)
   PUBMED   22958348
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9360653)
  AUTHORS   Rueckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-APR-2012) IGS, CeBiTec, Bielefeld University,
            Universitaetsstr. 27, D-33335, GERMANY
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000328705.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:06:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,523
            CDSs (total)                      :: 8,451
            Genes (coding)                    :: 8,313
            CDSs (with protein)               :: 8,313
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 43 of 138
            Pseudo Genes (incomplete)         :: 116 of 138
            Pseudo Genes (internal stop)      :: 7 of 138
            Pseudo Genes (multiple problems)  :: 27 of 138
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:45:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 762806
            Orig. end                         :: 784852
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            HE804045.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22046
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22046
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22046
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12046](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12046)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            409..951
                     /locus_tag="BN6_RS03725"
                     /old_locus_tag="BN6_07540"
     CDS             409..951
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS03725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_07540"
                     /product="hypothetical protein"
                     /protein_id="WP_015098197.1"
                     /transl_table=11
                     /translation="MTAPSPAGFEEPEVVRLAGGLPGWVLRAAIGVVALAVAGVLYAEG
                     VMIAPLVLYVGLAAVTVAIPASAAVILLVVYPAVAIVVVGGPPVRPGVLALVALTHLLH
                     VLSAYAALIPTRSRIHLKALRPAALRYVLVQAGVLVLAALVVLLSGGRTDEVVEVVAVV
                     CAVGLVAGAVALLRRRS"
     gene            1134..2459
                     /locus_tag="BN6_RS03730"
                     /old_locus_tag="BN6_07550"
     CDS             1134..2459
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631502.1"
                     /locus_tag="BN6_RS03730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07550"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_015098198.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 4.1e-46, bitscore:
                     156.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVKSHPTRIVIVGGGYVGMYTALGLQKKLRSGEASVTVIDPQP
                     HMTYQPFLPEAAAGSIEPRHVVVPLRKVLKRCHIVTGRATKVEHARKAVTVELADGHVE
                     EVEYDVLVSALGAISRTLPIPGLPEVGIGMKTIGEAIYLRNHVLSRLDQAASTNDPETR
                     KRLLSFVVIGGGFAGIETLAELEDMARYALRYYEGLKPDDMHWVLVEAAGRIMPEVSAK
                     LGVYTVEQLEKRGITCYLDTRVKSLEGGHVVLDDGTEFDSETIIWTAGMKANPVLRNTD
                     LPLDERGRVRCTAAMQVQGLPGVWAAGDCSAVPDLSRTEEDPTATCVPNAQHAIRQSKL
                     LAKNIVATLRGKPTKDYFHKYVGSVAGLGLYKGVGDVFGLRFKGVVAWFMHRSYHVMFM
                     PTVNRKFRVFVDWTQALFSGREVVALGQIHEPKAEFDRATKS"
     gene            2648..2770
                     /locus_tag="BN6_RS49460"
                     /old_locus_tag="BN6_07560"
     CDS             2648..2770
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="BN6_RS49460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="BN6_07560"
                     /product="hypothetical protein"
                     /protein_id="WP_015098199.1"
                     /transl_table=11
                     /translation="MSLEELAAQLRRGEIEDRALAEYAAEYATAGKVFRSKKDD"
     gene            2773..3891
                     /locus_tag="BN6_RS03735"
                     /old_locus_tag="BN6_07570"
     CDS             2773..3891
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098200.1"
                     /locus_tag="BN6_RS03735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07570"
                     /product="RimK family alpha-L-glutamate ligase"
                     /protein_id="WP_015098200.1"
                     /transl_table=11
                     /translation="MPASGWGDDPVPPSEAVKPVKPTPLLLQGQDYTFRSPAKNLDFQE
                     QVHRLGMVEEGDGGPVPCVLVLARATDMEMNALSIALAERGIRMARIDADRCVDLPLTV
                     YTDSPLLELDRWLLRPLLVWRRHFELSALQVEPGTLAGAYAVDQWGSVANWLTTRRDWA
                     HVNPARSTTHLDRLTQLSDAAAFGLEVPRTMVTTRPGRTRPGGARCIVKTTGRHLLEPR
                     PGVQHGLFPRPLETSRYGDVPESAPVIVQEYVPADTELRVFVVGERTLSFQVDKLDPAQ
                     LWVDPEAVRVTPVDTPPRLADRLLALARHWRLQVAAFDLLVAGGDHVFLEVNVNCDWRW
                     FEHRAEDERVSDAVHEWVAARFKELLSAGKGR"
     misc_feature    3691..3693
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3872..4942
                     /locus_tag="BN6_RS03740"
                     /old_locus_tag="BN6_07580"
     CDS             3872..4942
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098201.1"
                     /locus_tag="BN6_RS03740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07580"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_015098201.1"
                     /sec_met_domain="PF00881 (E-value: 1.1e-16, bitscore: 60.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVKVAEHAALFYQDGAVVWDDYLHHRQFAISETAELLCRKFTEF
                     TDVDVLLGPLGEADQAALRKVLDELVDAGVLLVEGSPQHDAERRMLAGWGPWGASARHF
                     HFASRTLADAPYQGSDEHDAILDVKLTREPPPAPFRTFGGSAVPLPPLPADPDWAASGL
                     LDVLLTRRTTREFGTARVALGRVGELLGVLAAPSPARPRIGRTGTVFKTSPSGGGRHPV
                     EIYAHTRGVEGVVDGWHHYEGFAHALEPLGVAWSPAEMAEAAGDQEWVGQAPLVLAYTA
                     VLERTRWRYDTSRAYRVVQMDVGHLSQTAYLVATAMGFGIGFTAALRDELLEQALHCDA
                     YHEVVLGMSALGPLPE"
     misc_feature    4931..4933
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     tRNA            5030..5103
                     /anticodon=(pos:767870..767872,aa:Leu,seq:taa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="BN6_RS03745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="BN6_07585"
                     /product="tRNA-Leu"
     gene            5030..5103
                     /locus_tag="BN6_RS03745"
                     /old_locus_tag="BN6_07585"
     gene            complement(5375..7006)
                     /locus_tag="BN6_RS03750"
                     /old_locus_tag="BN6_07590"
     CDS             complement(5375..7006)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098202.1"
                     /locus_tag="BN6_RS03750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07590"
                     /product="DUF885 family protein"
                     /protein_id="WP_015098202.1"
                     /transl_table=11
                     /translation="MDTTAALADELLDLMSRLSPLGATIYGLPGYDHLLADHRPETEET
                     TRAAAVRIAERARALPDDDDPVTRAVVVQQAESTVDLIDARSVEYTITDSFFAPAGELL
                     SVLPIVAPADEEQERAYLSRLATVPAFLRTVAERQVAGSAAGRTPVQHLVAAALAHLDR
                     YLAAEEDPFARPQGGAGFTAERDRLIAGQVRPAFAAYRDVVAGLSGRPTDQVGLCWLPE
                     GEAVYAALARAQTTTTRSPKELHETGLAIMAELAEEYAELGERVFGTRDTAAVFERMRE
                     DPALRWRSEDELISAAREAVTRAEEAAPRWFGRVPERRCEVEPVPAVDAPGAPTAFYAP
                     PSMDGTRLGTYYANTHRVEERFRYQAEAIAFHEAVPGHHFQIVLAQELADLPMLRRVAT
                     VTGYLEGWGLYCERLADEMGLYSDDVARLGMLAMDSMRAGRLVVDTGLHAHGWSRERAI
                     AYLRENTPLAQVEIESEVDRYIAAPGQALAYMVGRLEIQRVRAEAERALGDRFDIRAFH
                     DVVLGGGPLPLAVLDEVVRTWVAAQA"
     gene            complement(7062..7709)
                     /locus_tag="BN6_RS03755"
                     /old_locus_tag="BN6_07600"
     CDS             complement(7062..7709)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098203.1"
                     /locus_tag="BN6_RS03755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07600"
                     /product="response regulator transcription factor"
                     /protein_id="WP_015098203.1"
                     /transl_table=11
                     /translation="MRVVLGEDLVLLRDGLIRLLQAYDFDVVEAVDSGPALLKAMVDHR
                     PDVAVVDVRLPPTFTDEGLRAAIEARKRVPGLPVLVLSQYVEQLYARELLSDRGGGVGY
                     LLKDRVSDVTQFVDAIKRVAAGGTAMDPEVITQLLARSGRDRPLATLTPREREVLSLMA
                     EGRSNGAIAARLFVTEKAVGKHTANIFGKLDLPLSEDDNRRVLAVLAYLDRL"
     gene            complement(7661..8941)
                     /locus_tag="BN6_RS03760"
                     /old_locus_tag="BN6_07610"
     CDS             complement(7661..8941)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098204.1"
                     /locus_tag="BN6_RS03760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07610"
                     /product="sensor domain-containing protein"
                     /protein_id="WP_015098204.1"
                     /transl_table=11
                     /translation="MTDHDLVRGAGTRIKAAAFGLARVPLCVIGLPLIPLQLYAYPLVL
                     VTVGVPMLLLFTAITRRYLLVHRRWAGNVLGAEIALPYRVPANRGPMTRVRAIATDPQT
                     WKELGFLPLNAIVGVLCGVLPTALWLGGLFGFVTPLLWMFGADDVDYSGITPDVPGSFL
                     IAPLMGSLYLVIAWWATPRVVRLHARFVRFFLAPSQTEALTHRVRELADSRADTVDAQA
                     AELRRIERDLHDGAQARLVALGMSLGMAEELLVRDPDAARGLLVEARQSSSQALSELRD
                     LVRGIHPPVLADRGLDGALRALALAHPLPVEVDLVLAGRPEAPVESAAYFAVAETLTNV
                     AKHSGATSAWVRVRHDDGRLALMIGDNGRGGAEATENGGLRGIERRLAAFDGTLGIASP
                     VGGPTIVTMELPCELSSVKTSSSSGTA"
     misc_feature    complement(8898..8911)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            complement(9129..10004)
                     /gene="pqqB"
                     /locus_tag="BN6_RS03765"
                     /old_locus_tag="BN6_07620"
     CDS             complement(9129..10004)
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098205.1"
                     /locus_tag="BN6_RS03765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07620"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_015098205.1"
                     /transl_table=11
                     /translation="MKVVLLGTAAGGGVPQWNCACGPCAKVRAGALPARTQDCLAVSGN
                     GEDWWLLNASPDIRAQITATPLLDPGPGPRDTPVRGVLFTDAEVDHTLGLLTLRGAVGL
                     RVHAPATVLHALGDARAVLDKYAEWTWRQVEPEQTFALAGGLEVTAFPVSGKRPRYAGE
                     SPVAGHWVMAYRVFDPATGGIVLYAPCLAGWPLGFDDLVAEADVVLLDGTFYAPSEMGS
                     ATGRTGGQSAMGHLPITHTLPELRRHPGVRRIYTHLNNTNPVLDPDSDEHAKLREAGVE
                     VLPDGAVLDV"
     gene            complement(10001..11071)
                     /gene="pqqE"
                     /locus_tag="BN6_RS03770"
                     /old_locus_tag="BN6_07630"
     CDS             complement(10001..11071)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098206.1"
                     /locus_tag="BN6_RS03770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07630"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_015098206.1"
                     /sec_met_domain="PF04055 (E-value: 1.4e-18, bitscore: 66.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.5e-09, bitscore: 37.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7e-10, bitscore: 38.1,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEAPFGLLAELTHRCPLQCGYCSNPVELVRRDAELDTAEWCSVF
                     DQARAMGVLQFHLSGGEPLARKDLPELVSHAAGLGGYLNLVTSGLGLTAARLADLHSRG
                     VDHVQLSVQDAVRANADLIAGVRAFDHKLAAARLIGEAGLPLTVNVVLHRRNLDHVAGI
                     IELAEQMGADRLELANTQYYGWALRNRAALLPTRDQLDRAGAVVAAARERSRMEIVYVI
                     ADYHEAHPKPCMYGWGAQQLTVAPNGDVLPCPAAGVIDGLGVENVRDRPLAAIWHESGS
                     FNAFRGFDWMREPCRSCVRKEIDFGGCRCQAFQLTGDAANTDPVCSLSPRRTEVDLILA
                     AETTAPAALTMRKVAR"
     gene            complement(11064..11333)
                     /gene="pqqD"
                     /locus_tag="BN6_RS03775"
                     /old_locus_tag="BN6_07640"
     CDS             complement(11064..11333)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098207.1"
                     /locus_tag="BN6_RS03775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07640"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_015098207.1"
                     /sec_met_domain="PqqD_RRE (E-value: 7.1e-19, bitscore:
                     66.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.1e-10, bitscore: 39.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLDATPRLGKGVKTSYDQTRESHVVLFPEGVLVLNETAAAVVG
                     LCDGHTTITGIAAKLAEDFDGVRPEDVADLVARLTARKVVVTDG"
     aSDomain        complement(11079..11327)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_BN6_RS03775_PqqD_RRE.1"
                     /evalue="2.30E-21"
                     /identifier="RREFam006.1"
                     /label="BN6_RS03775"
                     /locus_tag="BN6_RS03775"
                     /protein_end="85"
                     /protein_start="2"
                     /score="66.3"
                     /tool="antismash"
                     /translation="DLDATPRLGKGVKTSYDQTRESHVVLFPEGVLVLNETAAAVVGLC
                     DGHTTITGIAAKLAEDFDGVRPEDVADLVARLTARKVV"
     gene            complement(11330..12046)
                     /gene="pqqC"
                     /locus_tag="BN6_RS03780"
                     /old_locus_tag="BN6_07650"
     CDS             complement(11330..12046)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098208.1"
                     /locus_tag="BN6_RS03780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07650"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_015098208.1"
                     /sec_met_domain="TIGR02111 (E-value: 6.2e-84, bitscore:
                     280.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPSTEEEFTARLRALSSRYWDSHPFHLRLHAGELSKDELRLWA
                     ANRWYYQRCIPRKDAAILANCPDQDVRRQWRERIVWHDGERAGEGGAENWLRMAEALGL
                     TREEVLDERHVLPGTRFAVDAYVTFARTRPWVEAVASGLTEMFSRGLMTRRLADMRERY
                     PWIAEEGFTYFTTRLKVIEGEGKSTLDLVVRNCRTREHQDAAVAALAFKCDVLRAILDA
                     VDYYAVGGADRTTGRS"
     misc_feature    complement(12171..12187)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    complement(12221..12234)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.35"
                     /tool="antismash"
     gene            complement(12465..12569)
                     /gene="pqqA"
                     /locus_tag="BN6_RS42880"
                     /old_locus_tag="BN6_07660"
     CDS             complement(12465..12569)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670613.1"
                     /locus_tag="BN6_RS42880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07660"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_015098209.1"
                     /transl_table=11
                     /translation="MSAEKTPKPKRTWVKPDFRDVDTPMEVTAYAARG"
     gene            12785..13804
                     /locus_tag="BN6_RS03785"
                     /old_locus_tag="BN6_07670"
     CDS             12785..13804
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098210.1"
                     /locus_tag="BN6_RS03785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07670"
                     /product="sorbosone dehydrogenase family protein"
                     /protein_id="WP_015098210.1"
                     /transl_table=11
                     /translation="MRARLGVVLALATLGATVVAPAQAGPAQLAVRTLATGQAVPWDIG
                     FLPDGSGIYTERDTKKIKKITGTTVTTLHTVNEAVPGGEGGLMGIAVSPTFANDNTVYI
                     YYTAASDNRVSRLKIGGGAPEPIVTGIPKNRFHNGGGLEFGPDGHLWATTGDAGNTANA
                     QNTASLAGKVLRFTTTGAPAPGNPFNNRVYSYGHRNPQGITWAGDRAYATEFGNNRTDE
                     LNWIQLGKNYGWPTCEGPCNDTRFVNPVKSWPTSSAGPSGIALYKNALYVASVTGRRVW
                     KIPVNGTELGTPEAVFTGYGRVRSAAAAPDGTLWLGTSNRDGRGTPATTDDRLLSTDG"
     gene            complement(13950..15104)
                     /locus_tag="BN6_RS03790"
                     /old_locus_tag="BN6_07680"
     CDS             complement(13950..15104)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098211.1"
                     /locus_tag="BN6_RS03790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07680"
                     /product="hypothetical protein"
                     /protein_id="WP_015098211.1"
                     /transl_table=11
                     /translation="MKRRRLITTGIALALVLAVLAVQGAQEPRPTEEVGELAAPLPIAP
                     RVPSSANAPTPTLPPPATAPKWMKRMQPGEKPPQFVLFSFDGAASKEHWDRVLPISRRT
                     GAHVTGLLSGVYLVPDADKATYAGPGHRAGYSAIQFGGTRQDVANRIAYLNEALAAGHE
                     IGTHYNGHFCQGDDPGVGRWTTADWDRELDQFFAILDKARAQGFTLDPAAVRGGRTPCL
                     EGDWGQAFPSMRGHGLAYDTSHVSLGVTWPTVQGGMWEFPLPEVRVPALGRQVVMMDYN
                     LWYALNGAKDEPGPPGEYARIVLDTYRSVYQAALNGNRAPLVVGNHFNEWAGGAFSEAV
                     EKFMEEVCVREETVCATYTEVIQWMQLQDPVVLEQFRRMPAALN"
     gene            complement(15142..15849)
                     /locus_tag="BN6_RS03795"
                     /old_locus_tag="BN6_07690"
     CDS             complement(15142..15849)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098212.1"
                     /locus_tag="BN6_RS03795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07690"
                     /product="class F sortase"
                     /protein_id="WP_015098212.1"
                     /transl_table=11
                     /translation="MIRADIRSITTGAVVAGLLVAAALVFSPGTEVVRGAPRPGDAVVP
                     FPLGDSMRSGRGTDLAGMPAGGNPPSSPTAPTTEQPPPPPPPAVQAPGTVKLPQGGIAT
                     LVRKEVTADGVLPVPEGVGEATWWGVDLGAAEGATVLAGHVNWKGMTGPFDELWRSAAG
                     QEVTVVDTAGKTFRFKISQVVTVRKDELPQRAVELFGPRGEHRLTLVTCGGRWVGGDTG
                     YEENQVVVATPVA"
     gene            complement(15886..17289)
                     /locus_tag="BN6_RS03800"
                     /old_locus_tag="BN6_07700"
     CDS             complement(15886..17289)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098213.1"
                     /locus_tag="BN6_RS03800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07700"
                     /product="collagen binding domain-containing protein"
                     /protein_id="WP_015098213.1"
                     /transl_table=11
                     /translation="MGWRRLAGAVLAAGVALLAVPATSDAQVQEGIGYTTPAQGYRGKP
                     GTTDWLGSYIWQGKHVWCVEYSLLAPDSTEEYKPGDELRTKAGEALAPDVAANISYLLL
                     RYTTNPSVDEAAALAHLLHSWTAYPHGKISLDPNNDFRHIAYNEQFHFDALPAPARDSV
                     TRLRADAEANRGPWTAKVIAPEKEQLIGSPGDWAVNIAKADGKFVADVPVTVELDQATL
                     EDGKTTVELRTPADGKALNVKVIPTGVKPTFKVKLDSPADKPVVHVPSSTDTQRIVTTG
                     GEKKLAAEASGTARTQPGIVKVGKTDAETGKAISGVALRVTGPDGVKPALKQDDSPLTG
                     PDGKPIVLQTGEDGTVAVPDLRTPQEICVVEVAAPKGYEENFDPNAPPKACGKVEPAQT
                     LALAIANKPNKPIVPITIPAGSDGSGVVATASFTTEFDTGALVGFGGLTLLSAAFIGFF
                     VRRRAAARP"
     gene            17751..18551
                     /locus_tag="BN6_RS03805"
                     /old_locus_tag="BN6_07710"
     CDS             17751..18551
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005155843.1"
                     /locus_tag="BN6_RS03805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07710"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_015098214.1"
                     /transl_table=11
                     /translation="MRTTSNPAFRNLPTSGGSGSYAGFGQPYEAQQYGGYQSAPPTTGE
                     RPITIDDVVTKTAITLATTLATGFISAWLVLSGQAKPLTLMLPGLIIGLVVSLIIIFKR
                     TPSAPLVLIYAAAEGVFLGAITGVFEGMFKGIAWQAILGTFGVFIAMLIVYKTGAIRVT
                     PRLTKWIIGATVGAAVLMLGNLVLGLFGVNVGLRDGGTLAIVFSLVVIGIAAFNFLLDF
                     EAANEMIRSGVPAKWAWWAAFGLMTTLVWLYLEILRLLSYLQRD"
     gene            complement(19257..20477)
                     /locus_tag="BN6_RS03810"
                     /old_locus_tag="BN6_07730"
     CDS             complement(19257..20477)
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /function="Involved in the degradation of long-chain fatty
                     acids"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466189.1"
                     /locus_tag="BN6_RS03810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07730"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_015098216.1"
                     /transl_table=11
                     /translation="MPEAVIVSAARSPIGRAGKGSLKDVRADDLTVQVLKAALAKVPQL
                     DPHDIDDLMLGCGLPGGEQGFNLGRVVSVLAGHDTLPGTTVTRYCASSVQTTRMALHAI
                     KAGEGDVFISAGVETVSSFARGSSDSWPNTHNPVFADAEARTKATAEQGATGWTDPRTT
                     GDVPDVYIAMGQTAENLALAKGVTREDMDHFGVRSQNLAEKAIANGFWAREITPVTLPD
                     GTVVSTDDGPRPGVTYEGVSGLKPVFRPDGRITAGNCCPLNDGAAALVVMSDTKAKELG
                     ITPLARVVSTGVSALSPEIMGLGPVEASKRALALAGLSIGDIDLVEINEAFAAQVIPSY
                     RDLGIDLDRLNVNGGAIAVGHPFGMTGARITTTLINSLQFHDKQFGLETMCVGGGQGMA
                     MVIERLS"
     gene            complement(20541..21332)
                     /locus_tag="BN6_RS03815"
                     /old_locus_tag="BN6_07750"
     CDS             complement(20541..21332)
                     /codon_start=1
                     /function="Lysophospholipase L1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098217.1"
                     /locus_tag="BN6_RS03815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="BN6_07750"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_015098217.1"
                     /transl_table=11
                     /translation="MKWWRLIAAAGLAAGGLTGVAYALFTTQSRRARVIIGVPDAPPLR
                     ADGVYGDHPGRPIRFAVLGDSMAAGLGVDTPEELPGVLLARALAEETATPIRLETYAIS
                     GSTTDDLPSQVDRVVTDPPDVALVIIGANDVTTRTPIPRSAATLGTQTARLRDAGIGVV
                     VGTCPDLGAIRPIGQPLRAVASEYSHRLARAQRQAVLDAGGVPVALGDLLAAEFTTRSR
                     DYFSRDQFHPSAAGYEAATSILLAPLYEAVLTHHDDLRHEW"
ORIGIN
        1 cgtgcgggcc ggtgccgggc ggcggcagct gctgcggctg cgcaaccagc tcgtggtgtg
       61 cgcgcggtcg gcgggctggg cgcagaagcc cgtgctgcgg gccgagcagg tgccgcacgg
      121 ggcgttggtg gtggtgctct cgccgttcct ggacgcggag gtggtcgagc tgacggtgca
      181 cgccgcgcgg cgcggcaacg tggtgctggc ggtggacgtg ctgccggagg gcctgcggcc
      241 ggaccggtcg accgagtggg gtgcggcgac gttgaaggtg ctggagctgg agcacgaggt
      301 gcggctggag gcgatgcgcc ggcacggcgt cccggtggtg acctgggacg cgcgggccgc
      361 cgccatctcc ggtgcgctgc gcgaggcggc ccggccgggg aggcggcgat gaccgcgccg
      421 tcgccggccg ggttcgagga gcccgaggtc gtccggttgg ccggcgggct gcccggctgg
      481 gtgttgcggg ccgcgatcgg ggtggtggcc ctggcggtcg ccggcgttct ttacgccgaa
      541 ggagtgatga ttgctccatt ggtgttgtac gtcggattgg ccgcagtgac cgtcgcgatt
      601 cccgcgtcag ccgccgtcat ccttctcgtc gtctatccgg cggtggcgat cgtggtggtc
      661 gggggcccgc cggtgcgtcc gggggtgctc gcgctcgttg ctctgacgca cttgttgcat
      721 gtgttgagcg cttacgcggc gctcatcccc acccgctcgc gcattcacct gaaagcgcta
      781 cgcccggcgg cgctgcgata cgtgctggtg caagccggtg tgctcgtcct ggcggcgctg
      841 gtggtcctgt tgtcgggcgg ccggacggac gaggtcgtcg aggtggtggc ggtcgtctgc
      901 gcggtcgggc tggtggccgg ggcggtagcg ctgctgcgcc ggcggagctg aggaacgggg
      961 tcggaaagct cagcgggagc tgagcgtctg gatcgttcct ctcagcacct tcacccgccg
     1021 gggcggcgct gtcgctggtc agcgcgctgc gtgttccgca tcacccggcg actgtggtca
     1081 caacggggct caccgacgcg tcggaaatcg ccctccggtg cgaccatgga cgtatggctg
     1141 ctgtgaagtc gcaccccaca cggatcgtga tcgtcggcgg tgggtacgtc ggcatgtaca
     1201 ccgcgctggg tctgcagaag aagctgcgtt ccggtgaggc gtcggtcacg gtcatcgacc
     1261 cacagcccca catgacctac cagccgttcc tccccgaggc ggcggccggg tcgatcgagc
     1321 cgcgccacgt ggtggtgccg ctgcgcaagg tcctcaagcg ctgccacatc gtcaccgggc
     1381 gcgccacgaa ggtcgagcac gcgcgcaagg cggtcaccgt cgagctggcc gacggccacg
     1441 tcgaggaggt cgagtacgac gtgctcgtct cggccctggg cgcgatctcg cggaccctgc
     1501 cgatccccgg cctgcccgag gtcggcatcg gcatgaagac catcggcgag gccatctacc
     1561 tgcgcaacca cgtgctgtcg cggctcgacc aggcggccag cacgaacgac ccggagaccc
     1621 gcaagcggct gctgagcttc gtggtcatcg gcggcggctt cgcgggcatc gagacgctgg
     1681 cggagctgga ggacatggcc cgctacgcgc tgcgctacta cgagggcctc aagcccgacg
     1741 acatgcactg ggtgctggtc gaggcggccg ggcggatcat gcccgaggtg agcgcgaagc
     1801 tcggcgtcta caccgtggag cagctggaga agcgcggcat cacctgctac ctcgacaccc
     1861 gggtcaagtc gctggagggc ggccacgtcg tcctcgacga cggcaccgag ttcgactcgg
     1921 agaccatcat ctggacggcc ggcatgaagg ccaacccggt gctgcgcaac accgacctgc
     1981 cgctcgacga gcgcggccgg gtccgctgca cggccgcgat gcaggtccag ggcctgcccg
     2041 gggtgtgggc ggcgggcgac tgctcggccg tgccggacct ctcgcgcacc gaggaggacc
     2101 cgacggcgac ctgcgtgccc aacgcgcagc acgccatccg ccagtcgaag ctgctggcca
     2161 agaacatcgt ggccaccctg cgcggcaagc cgaccaagga ctacttccac aagtacgtcg
     2221 gatcggtcgc gggcctgggc ctgtacaagg gcgtcggcga cgtgttcggc ctgcgtttca
     2281 agggtgtcgt cgcctggttc atgcaccgca gctaccacgt gatgttcatg cccaccgtga
     2341 accgcaagtt ccgggtgttc gtggactgga cgcaggccct gttctcgggc cgcgaggtgg
     2401 tcgcgctcgg tcagatccac gagccgaagg cggagttcga ccgggccacc aagagctgac
     2461 cggcggcggg cccgctgcgc tgttcggtcg cggtgggcaa gcacccgtct ggcttagggc
     2521 cgtaacttga gcccccaaat agcgtaatgg gcagcgcgtg accttgacat tgcgtaacgt
     2581 gaacccgaga ctacgactgg cgcgccacca aaagtgtgat gcgccagtgg ggagagaggt
     2641 gaccgcgatg tcgcttgagg agctggccgc acagcttcgc cgcggtgaga tcgaggaccg
     2701 tgccctggcg gagtacgccg ccgagtacgc caccgccgga aaggtttttc gcagcaagaa
     2761 agacgactga gcatgcccgc ttccgggtgg ggggacgatc cggttccccc atccgaggcc
     2821 gtcaagcccg tcaagcccac cccactgctg ctgcaaggtc aggactacac cttccggtcc
     2881 ccggccaaga acctggactt ccaggagcag gtgcaccgcc tcgggatggt cgaggagggt
     2941 gacggcggcc cggtgccgtg cgtgctggtc ctcgcccgcg ccaccgacat ggagatgaac
     3001 gcgctctcca tcgcgctggc cgagcgcggc atccggatgg cccgcatcga cgccgaccgc
     3061 tgcgtcgacc tgccgctcac cgtctacacc gactcgcccc tgctcgaact cgaccgctgg
     3121 ctgctgcgcc cgctgctggt gtggcgccgg cacttcgagc tctccgcgct ccaggtcgaa
     3181 cccggcacgc tggccggcgc gtacgccgtg gaccagtggg gttcggtggc caactggctg
     3241 accacccgcc gcgactgggc gcacgtcaac ccggcccgca gcacgaccca cctcgaccgg
     3301 ctcacccagc tctcggacgc ggccgcgttc gggctggagg tcccgcgcac catggtcacc
     3361 acccgtcccg gccggacccg gcccggcggc gcgcggtgca tcgtcaagac caccggccgg
     3421 cacctgctgg agccgcgccc cggtgtgcag cacggcctgt tcccccgtcc cctggagacc
     3481 agtcgctacg gcgacgtgcc ggagtccgca ccggtgatcg tccaggagta cgtacccgcc
     3541 gacaccgagc tccgggtgtt cgtggtgggg gagcgcaccc tctcgttcca ggtcgacaag
     3601 ctggatccgg cccagttgtg ggtcgatccc gaggccgtcc gggtgacccc ggtggacacg
     3661 ccgccgcggc tcgcggaccg gctgctcgcc ttagcccggc actggcggtt gcaggtcgct
     3721 gcgttcgacc tgctcgtagc gggcggcgac cacgtgttcc tggaggtcaa cgtcaattgc
     3781 gactggcgtt ggttcgaaca ccgcgccgag gacgaacggg tgtccgacgc cgtgcacgag
     3841 tgggtcgcgg cgcgtttcaa ggagctgctg agtgcgggta aaggtcgctg agcacgcggc
     3901 gttgttctac caggacggcg ctgtggtgtg ggacgactac ctgcaccacc gccagttcgc
     3961 gatcagcgag acggccgagc tgctgtgccg caagttcacc gagttcaccg acgtcgacgt
     4021 gctgctcgga ccgctgggcg aggccgacca ggccgcgctg cgcaaggtcc tcgacgagct
     4081 ggtcgacgcg ggcgtgctgc tggtggaggg ctcgccgcag cacgacgcgg agcgccggat
     4141 gctggccggc tgggggccgt ggggcgcgtc cgcccggcac ttccacttcg ccagccgcac
     4201 cctggccgac gcgccctacc agggctcgga cgagcacgac gcgatcctgg acgtgaagct
     4261 gacccgggaa ccgccgcccg cgccgttccg cacgttcggc gggtccgccg tgccgctgcc
     4321 gccgctgccc gccgacccgg actgggccgc cagcgggctg ctggacgtgc tgctgacccg
     4381 gcgcaccacc cgggagttcg gcaccgctcg ggtcgcgttg ggccgagtgg gtgaactact
     4441 gggcgtgctg gccgcgccgt cgcccgcccg tccccggatc gggcgcaccg gcacggtgtt
     4501 caagaccagc ccgtcgggcg gcggccggca cccggtggag atctacgcgc acacccgcgg
     4561 ggtcgagggc gtggtcgacg ggtggcacca ctacgagggg ttcgcgcacg cgctggagcc
     4621 gctgggggtg gcgtggtcgc ccgccgagat ggcggaggcg gccggtgacc aggagtgggt
     4681 cgggcaggcg ccgttggtcc tcgcgtacac ggcggtactc gaacggacca ggtggcgtta
     4741 cgacacgtca cgggcttatc gggttgtgca aatggacgtg ggccatctgt cgcaaaccgc
     4801 ttatctggtt gctaccgcaa tgggttttgg tatcggcttc accgcagcat tgcgggatga
     4861 actcctcgaa caggcactcc actgtgacgc ttatcacgaa gtcgtacttg gcatgagcgc
     4921 gctgggtcca ttacctgaat gagcgcaata gcggatggca ttgagccgtg cgggggactt
     4981 gtgccgaacc ggccccacga acgctcggta acggcttagg ctcctcgctg cccccgtagc
     5041 ccaatcggta gaggcaggct ccttaaaaga gtcacagtac gggttcgaat cccgtcgggg
     5101 gcacgtgtac cgcaaccttc gtagtcactc gactgccgag tgatcgcgaa cgagcggccg
     5161 agtcggtcga gagcggccga ctcgggtgtg ccggtcggat atcggggtat gcgcttgtca
     5221 atgccccgaa agggcagtgt cgcgccccgg cggtggtgtg atgccggggc ctggcccaga
     5281 ccaagcccgg acgacgcgca gacgacgcgg cgggcggctc agaggtgccg agccgcccgc
     5341 cgcgcgtcat gcccaggtcg tcatgtcggg gtcgttacgc ctgcgcggcc acccaggtcc
     5401 gcacgacctc gtccagcacg gccagcggca gcggcccgcc gcccagcacc acgtcgtgga
     5461 acgcccggat gtcgaaccgg tcgcccagcg cccgctcggc ctccgcccgc acccgctgga
     5521 tctccaaccg ccccaccatg taggccagcg cctggcccgg cgcggcgatg tagcggtcca
     5581 cctcggactc gatctccacc tgcgccagcg gcgtgttctc ccgcaggtac gcgatggccc
     5641 gctcgcggct ccagccgtgc gcgtgcagcc cggtgtccac gaccagccgg cccgcccgca
     5701 tcgagtccat ggccagcatc cccagccgcg ccacgtcgtc ggagtacagc cccatctcgt
     5761 cggccagccg ctcgcagtac aggccccagc cctccaggta cccggtgacc gtcgcgaccc
     5821 ggcgcagcat cggcaggtcg gccagctcct gcgccagcac gatctggaag tggtgccccg
     5881 gcaccgcctc gtggaacgcg atcgcctcgg cctggtaccg gaagcgctcc tccacgcggt
     5941 gcgtgttggc gtagtaggtg cccagccgcg tcccgtccat cgacggcggc gcgtagaacg
     6001 ccgtcggcgc gcccggcgcg tccacggccg gcaccggctc gacctcgcag cgccgctccg
     6061 gcacccggcc gaaccagcgc ggcgcggcct cctcggcccg ggtcaccgcc tcgcgcgcgg
     6121 cggagatcag ctcgtcctcc gaccgccagc gcagcgccgg gtcctcgcgc atccgctcga
     6181 agaccgccgc ggtgtcgcgg gtgccgaaca cccgctcgcc gagttcggcg tactcctcgg
     6241 ccagctccgc catgatggcg agcccggtct cgtgcagctc cttgggagac cgcgttgtgg
     6301 tggtctgagc gcgcgccaga gccgcgtaga cggcttcgcc ctccgggagc cagcacaggc
     6361 ccacctgatc cgtgggacgg ccgctgagcc ccgctacgac gtcccggtag gcggcgaacg
     6421 ccggccgcac ctgtccggcg atgagccggt cccgctcggc ggtgaacccc gcgccgccct
     6481 gcggccgggc gaacgggtcc tcctcggcgg ccaggtagcg gtccaggtgg gcgagcgccg
     6541 cggccacgag gtgctggacc ggcgtgcggc cggcggcgga accggcgacc tggcgctcgg
     6601 cgaccgtgcg caggaacgcc gggaccgtcg cgagccggga caggtaggcc cgctcctgct
     6661 cctcgtccgc gggcgcgacg atcggcagca ccgacagcag ctcgcccgcc ggggcgaaga
     6721 acgaatcggt gatcgtgtac tcgacggaac gcgcgtcgat caggtccacg gtggattcgg
     6781 cctgctggac gacgaccgcg cgggtgaccg ggtcgtcgtc gtcgggcagc gcccgcgcgc
     6841 gttccgcgat ccgcacggcg gcggcccggg tcgtttcctc ggtctccggc cggtggtcgg
     6901 cgagcaggtg gtcgtatccg ggcagcccgt agatcgtcgc gcccagcggg gacagccggg
     6961 acatcaggtc gagcagttca tcggcgagcg cggccgtcgt atccatcggt acccctggcg
     7021 tcggcgggaa agtcggaacg gtgcttagcc taaataacga tttacagccg gtccaaatag
     7081 gccagcaccg cgagcacccg gcggttgtcg tcctcggaca gcggcaggtc gagcttgccg
     7141 aagatgttgg cggtgtgttt gcccaccgct ttctcggtca cgaacagccg cgccgcgatc
     7201 gcgccgttcg accggccctc cgccatcagc gagagcacct cccgctcgcg cggggtcaac
     7261 gtggccagcg gccggtcccg cccgctgcgc gccaacagct gggtgatgac ctcggggtcc
     7321 atcgcggtgc cgcccgccgc gacccgcttg atggcgtcca cgaactgcgt gacgtcggac
     7381 acccggtcct tgagcaggta gccgacaccg ccgccgcggt cggacagcag ctcgcgggcg
     7441 tagagctgct cgacgtactg ggagagcacc agcacgggca gccccggcac ccgcttgcgc
     7501 gcctcgatcg ccgcccgcag gccctcgtcg gtgaacgtcg gcggcaggcg cacgtcgacc
     7561 accgccacgt ccgggcggtg gtcgaccatg gccttgagca gggcgggacc ggagtcgacc
     7621 gcctccacca cgtcgaagtc gtaggcctgg agcagccgga tcaggccgtc ccggaggagg
     7681 acgaggtctt caccgaggac aactcgcacg gcagctccat ggtcacgatc gtcggcccgc
     7741 ccaccgggct cgcgatcccg agggtgccat cgaaggcggc cagcctgcgc tcgattcccc
     7801 gcaatccccc gttctcggtc gcctccgcgc cgccccggcc gttgtcgccg atcatcagcg
     7861 cgagccggcc gtcgtcgtgc cgcacccgga cccacgcgct ggtcgccccg ctgtgcttgg
     7921 ccacgttcgt cagcgtctcg gcgaccgcga agtacgccgc cgactccacc ggcgcctccg
     7981 gccgcccggc cagcaccagg tccacctcga ccggcagcgg gtgcgccagc gccagcgccc
     8041 gcagcgcgcc gtccagcccg cggtcggcca gcaccggcgg gtggatcccg cgcaccaggt
     8101 cacgcagctc ggacagcgcc tgcgacgacg actggcgcgc ctcgaccagc agaccccggg
     8161 ccgcgtccgg gtcgcgcacg agcagttcct cggccatgcc caggctcatc cccagcgcca
     8221 ccagccgggc ctgcgcgccg tcgtgcaggt cgcgctcgat ccggcgcagc tcggcggcct
     8281 gcgcgtcgac cgtgtcggcc cgcgagtcgg cgagctcgcg cacccggtgg gtgagcgcct
     8341 cggtctggct cggcgcgagg aagaagcgca cgaaccgggc gtgcagccgg accacgcgcg
     8401 gcgtggccca ccaggcgatc accaggtaga gcgagcccat cagcggggcg atcaggaagc
     8461 tgcccggcac gtccggggtg atcccgctgt agtcgacgtc gtccgcgccg aacatccaca
     8521 gcagcggggt gacgaagccg aacagcccgc ccagccagag cgccgtgggc agcacgccgc
     8581 agagcacgcc gacgatcgcg ttgagcggca ggaaccccag ttccttccac gtctgcgggt
     8641 cggtggcgat ggcccgcacc ctggtcatcg ggccccggtt ggcgggcacc cggtagggca
     8701 gcgcgatctc cgcgcccagc acgttgcccg cccaccggcg gtggaccagc aggtagcgcc
     8761 gggtgatcgc ggtgaacagc agcagcatcg gcacgccgac cgtgaccagg accagcgggt
     8821 aggcgtagag ctgcaggggg atcaggggca ggccgatcac gcacagcggc acccgggcca
     8881 ggccgaacgc cgcggccttg atccgggtcc ccgcaccgcg cacgaggtcg tggtccgtca
     8941 tgcgggtgat tcttccgggt ggcaggggtg aaagcggtgg gcttaacccc ccgatcggcc
     9001 gggcacgtgc gcccgctccc gccgaccggg gcttcggcgg ggcgggcttc ggtggtgcgg
     9061 ggccggcgat ggtggtgggg ccggcggtgg tgggtaaggc cggcggcggt gggtgggatc
     9121 gaggtgggtc acacgtcgag gaccgcgccg tcggggagca cctcgacgcc ggcctcgcgc
     9181 agcttggcgt gctcgtcgga gtccgggtcg agcaccgggt tggtgttgtt gaggtgcgtg
     9241 tagatccgcc gcacgccggg gtggcggcgc agctcgggca gggtgtgcgt gatcggcagg
     9301 tgccccatcg cggactggcc gcccgtccgg ccggtcgccg agcccatctc cgagggcgcg
     9361 tagaacgtgc cgtccagcag caccacgtcc gcctccgcga ccaggtcgtc gaaccccagc
     9421 ggccacccgg ccaggcacgg cgcgtacagc acgatcccgc cggtcgccgg gtcgaacacc
     9481 cggtaggcca tcacccagtg cccggccacc ggcgactcgc cggcgtacct cgggcgcttg
     9541 ccgctgaccg ggaacgcggt cacctccagc ccgcccgcca gcgcgaacgt ctgctccggc
     9601 tcgacctgcc gccacgtcca ctcggcgtac ttgtccagca ccgcccgcgc gtcgcccagc
     9661 gcgtgcagca cggtcgcggg cgcgtgcacc cgcagcccca ccgcgccccg caacgtcagc
     9721 aggcccagcg tgtggtccac ctcggcgtcg gtgaacagca cgccgcgcac cggggtgtcg
     9781 cgcggtccgg ggccggggtc gagcagcggc gtcgcggtga tctgggcccg gatgtcgggg
     9841 gaggcgttga gcagccacca gtcctcgccg ttcccgctca ccgccaggca gtcctgggtc
     9901 cgcgcgggca gcgcgcccgc ccgcaccttc gcgcacggcc cgcacgcgca gttccactgc
     9961 ggcacaccgc caccggcggc cgttccgagc agcacgacct tcaccgcgcc accttccgca
    10021 tcgtcagcgc cgccggagcc gtggtctccg cggcgaggat caggtccacc tcggtgcgcc
    10081 gaggggacag cgagcacacc gggtcggtgt tcgccgcgtc gccggtgagc tggaacgcct
    10141 ggcaccggca cccgccgaag tcgatctcct tgcgaacgca cgaccggcac ggctcgcgca
    10201 tccagtcgaa cccgcggaag gcgttgaacg accccgactc gtgccagatc gcggccagcg
    10261 gccggtcccg gacgttctcc acccccaggc cgtcgatcac gcccgccgcc gggcacggca
    10321 ggacgtcccc gttcggcgcg acggtgagct gttgcgcgcc ccacccgtac atgcacggct
    10381 tggggtgcgc ctcgtggtag tccgcgatca cgtagacgat ctccatccgc gaccgctcgc
    10441 gggccgctgc caccaccgcg cccgcccggt cgagctggtc ccgggtgggc agcagggcgg
    10501 cccggttgcg cagcgcccag ccgtagtact gggtgttggc cagctccagc cggtccgcgc
    10561 ccatctgctc ggccagctcg atgatcccgg ccacgtggtc gaggttgcgg cggtgaagga
    10621 cgacgttgac cgtcagcggc agccccgcct cgccgatcag ccgcgcggcg gcgagcttgt
    10681 ggtcgaacgc ccggacaccg gcgatcaggt cggcgttggc gcgcaccgcg tcctgaacgg
    10741 acagttgcac gtggtcgacg ccccgggaat gcaggtcggc caaccgcgcg gcggtcaggc
    10801 ccagcccgct ggtcaccagg ttcaggtacc cgccgagccc ggcggcgtgg ctcaccagct
    10861 ccgggaggtc cttgcgcgcc aacggttccc cgccggacag gtggaactgg agcacgccca
    10921 tggcccgcgc ctggtcgaac accgagcacc attcggcggt gtcgagctcg gcgtcccggc
    10981 gcaccagctc caccgggttc gagcagtagc cgcactgcag cgggcagcgg tgggtgagtt
    11041 cggcgagcag cccgaacggt gcctcagcca tcggtcacca ccaccttgcg cgcggtcagc
    11101 cgggcgacga ggtcggcgac gtcctcgggc cgcaccccgt cgaagtcctc ggccagcttc
    11161 gccgcgatac cggtgatcgt ggtgtgcccg tcgcacagcc cgaccaccgc cgcggcggtc
    11221 tcgttgagca ccagaacacc ttcggggaac agcactacgt ggctctcccg ggtctggtcg
    11281 taagaggtct tcacgccctt gccgagccgt ggtgtcgcat cgagatcggt catgatcgtc
    11341 ctgttgtccg gtcggcgccg ccgaccgcgt agtagtcgac tgcgtcgagg atcgcccgca
    11401 gcacgtcgca cttgaacgcc aacgcggcca ccgccgcgtc ctggtgctcc ctggtccggc
    11461 agttgcgcac caccaggtcc aaagtggact tcccctcgcc ctcgatcacc ttcaggcgcg
    11521 tggtgaagta ggtgaagccc tcctcggcga tccaggggta ccgctcccgc atgtcggcca
    11581 accggcgggt catcaggccg cgcgagaaca tctcggtgag cccggacgcc accgcctcta
    11641 cccacggtct ggtgcgcgcg aaggtcacgt aggcgtcgac ggcgaacctc gtgccgggca
    11701 gcacgtgccg ctcgtcgagc acctcctcgc gggtcaggcc cagcgcttcg gccatccgca
    11761 gccagttctc cgcaccgccc tcgcccgcgc gctcgccgtc gtgccagacg atccgctccc
    11821 gccactgccg gcggacgtcc tggtccgggc agttggccag gatcgcggcg tccttgcgcg
    11881 ggatgcagcg ctggtagtac caccggttcg cggcccacag ccggagttcg tccttggaca
    11941 gctcgcccgc gtgcagccgg aggtggaacg ggtggctgtc ccagtagcgg gaggagagcg
    12001 cccgcagccg ggcggtgaac tcctcctcgg tcgacggctc ggacatgcgc gcgcctccag
    12061 ggtctccggt ctgcttcgcg tccggcgagt gctgccccca cgcggttccg catcggctcg
    12121 acgcgcccac gtctcgaatg gcgtgagtgc gtcgggtcgt gactgcgttg ttgcgagtgc
    12181 gttgcgagtg cgttggcgtg ggtgtggtgg gccggtgtgg tgcgtgtgca tccgtgtgag
    12241 cgtgggcttt ttgcacgggc gtggtgtgtg ggcagggttc gtgggacgtt gagcttcggc
    12301 cgctgcttgg gacgtgcttt tggcgtggcg cttgggtgtg gtgcgtgggg tcgtgcgtgg
    12361 ggtgacgctt gtgggtggtg catggggtgg cgcggtgtga tcgcaccacg tcgtggctcc
    12421 gcccgcgaga tcgcgcccgg agccacgacg gagggcgtgc cggctcagcc gcgcgcggcg
    12481 tacgcggtga cttccatcgg cgtgtcgacg tcccggaagt ccggcttgac ccaggtgcgc
    12541 ttcggcttcg gcgtcttctc ggctgacatt gcgcgactcc tcggattcgg tgtgtctctc
    12601 cgtgggtcgg cggcggagtc cccacggtag agcgttcggg ggtggatccg ctagaacgta
    12661 aggagggttg cctaatcgag tagtggtctg tcctccgatg aatgttgccc gatttgtgcg
    12721 ggcgtggttg agtcgtgggg accgccgttc cgccgccgtg acagtgcgga catggaggca
    12781 gcacatgcgc gctcgtctag gcgtggtcct ggccctggcg acactgggcg cgaccgtcgt
    12841 cgcgcccgcc caggccggcc cggcgcaact cgcggtgcga acgctcgcca ccggtcaggc
    12901 agtcccgtgg gacatcggtt tcctgcccga cggcagcggc atctacaccg aacgcgacac
    12961 gaagaagatc aagaagatca ccggaaccac ggtgacgacc ctgcacaccg tgaacgaagc
    13021 agtgcccgga ggcgaaggcg gcctgatggg catcgcggtg tcgccgacct tcgccaacga
    13081 caacaccgtc tacatctact acacggccgc cagtgacaac cgggtctccc gcctcaagat
    13141 cggcggcggg gcgccggagc cgatcgtgac cggcatcccg aagaaccggt tccacaacgg
    13201 cggtggcctg gagttcggcc cggacggcca cctgtgggcg accacgggcg acgcgggcaa
    13261 caccgccaac gcgcagaaca cggcctcgct cgcgggcaag gtcctgcgct tcaccacgac
    13321 cggcgcgccc gcgccgggca acccgttcaa caaccgggtg tactcctacg gccaccgcaa
    13381 cccgcagggc atcacgtggg ccggcgaccg ggcgtacgcg acggagttcg gcaacaaccg
    13441 gaccgacgag ctgaactgga tccagctggg caagaactac ggctggccga cgtgcgaagg
    13501 gccgtgcaac gacaccaggt tcgtgaaccc ggtgaagtcg tggccgacca gttccgccgg
    13561 accttccggc atcgcgctgt acaagaacgc cctgtacgtc gcgagcgtga ccggtcggcg
    13621 ggtctggaag atcccggtca acgggaccga actgggcacg ccggaagcgg tgttcaccgg
    13681 ctacggccgg gtccggtcgg cggcggcggc cccggacggg acgctgtggc tgggcacctc
    13741 gaacagggac ggtcggggca ccccggccac caccgacgac cggctgctga gcaccgacgg
    13801 ctgagtgccg acggctgagt gccgacggct gagtgccgac ggctgggcaa cggctgtcgg
    13861 tgtggaagtc gagtctggcc gggtgtccgc ggcggcggtc gcgggcaccc ggcccgttcg
    13921 gggccgtgcg tagtgcgagg gacgaacagt cagttgagtg cggcgggcat tcggcggaac
    13981 tgttcgagga cgacggggtc ctgtagttgc atccactgga tgacctcggt gtaggtggcg
    14041 cacacggtct cctcgcgcac gcacacctcc tccatgaact tctccaccgc ctcgctgaag
    14101 gcgcccccgg cccactcgtt gaagtggttg cccaccacca gcggggcgcg gttgccgttg
    14161 agggcggcct ggtagaccga gcggtaggtg tccagcacga tccgggcgta ctcgccgggc
    14221 ggtccgggct cgtccttcgc gccgttcaag gcgtaccaga ggttgtagtc catcatcacg
    14281 acctgccgcc ccagcgcggg cacccgcacc tcgggcagcg ggaactccca catgccgccc
    14341 tgcaccgtcg gccaggtcac gcccaggctc acgtgactgg tgtcgtaggc caggccgtgc
    14401 ccccgcatgg acgggaacgc ctgcccccag tcgccttcca ggcacggcgt ccggccgccg
    14461 cgcacggccg ccgggtcgag ggtgaacccc tgcgcgcggg ccttgtccag gatcgcgaag
    14521 aactggtcca gctcgcggtc ccagtcggcg gtggtccagc ggcccacgcc cgggtcgtcg
    14581 ccctggcaga agtggccgtt gtagtgggtg ccgatctcgt gcccggcggc cagcgcctcg
    14641 ttcaggtagg cgatccggtt cgcgacgtcc tggcgggtgc cgccgaactg gatcgccgag
    14701 tacccggcgc ggtgcccggg accggcgtag gtcgccttgt cggcgtccgg gaccaggtag
    14761 acgccggaga gcaggccggt cacgtgcgcg ccggtccgcc gcgagatcgg cagcacccgg
    14821 tcccagtgct ccttggacgc cgccccgtcg aacgagaaca gcacgaactg cggcggcttc
    14881 tcaccgggct gcatccgctt catccacttc ggcgcggtcg ccggcggtgg caacgtgggc
    14941 gtgggggcgt tcgcgctgga cggcacgcgc ggcgctatcg gcagcggcgc ggccagttcg
    15001 ccgacctcct cggtggggcg gggctcctgg gcgccctgga cggccaacac cgccaggacg
    15061 agggccagcg cgataccggt ggtgatcaga cgcctgcgct tcacacaggg gaagacgacc
    15121 cagcgtgtcc gccggttgcc tctacgcgac gggcgtggcc acgacgacct ggttctcctc
    15181 gtacccggtg tcgccgccga cccaccggcc accgcaggtg accagcgtca gccggtgctc
    15241 gccgcgcgga ccgaacagct cgacggcccg ctggggcagt tcgtccttcc gcaccgtgac
    15301 gacctggctg atcttgaagc ggaaggtctt gcccgcggtg tcgaccacgg tcacctcctg
    15361 accggcggcg gagcgccaca gctcgtcgaa cgggccggtc atgcccttcc agttgacgtg
    15421 cccggcgagc accgtcgcgc cctcggccgc gccgaggtcc acgccccacc aggtcgcctc
    15481 gccgacgccc tccgggacgg gcagcacgcc gtccgcggtg acctccttgc ggaccagggt
    15541 ggcgatgccg ccctggggca gcttcaccgt gccgggggcc tgcacggccg gcggcggcgg
    15601 cggtgggggc tgctccgtcg tgggcgctgt cgggctggag ggcgggttgc cgcccgccgg
    15661 catcccggcc aggtcggtgc cgcgcccgga cctcatgctg tcgccgagcg ggaacggcac
    15721 caccgcgtca ccgggccggg gcgcaccccg gacgacctcg gtgcccgggg agaacaccag
    15781 cgcggcggcg acgaggagtc ccgccaccac cgcgccggtc gtgatcgatc tgatgtccgc
    15841 tcggatcacg gacgcactgc ctcggtcatg ggtgcacagc ctcggtcatg ggcgggcggc
    15901 cgccctgcgg cggacgaaga agccgatgaa ggccgcgctg agcagcgtca ggccgccgaa
    15961 cccgaccagc gcgccggtgt cgaactcggt ggtgaacgac gcggtggcca ccacgcccga
    16021 gccgtcggaa ccggccggga tggtgatcgg gacgatgggt ttgttgggtt tgttggcgat
    16081 cgccagcgca agcgtttgcg caggctcgac cttgccgcac gccttgggcg gcgcgttcgg
    16141 gtcgaagttc tcctcgtagc ccttcggcgc ggcgacctcg acgacgcaga tctcctgcgg
    16201 tgtccgcagg tccggcacgg cgaccgtgcc gtcctcgccg gtctggagca cgatcggctt
    16261 gccgtccggg ccggtcagcg gcgagtcgtc ctgcttgagg gcgggcttga cgccgtccgg
    16321 gccggtgacc cgcagcgcca cgccggagat cgccttgccg gtctccgcgt cggtcttgcc
    16381 gaccttcacg atgcccggct gggtgcgggc ggtgcccgac gcctcggccg ccagcttctt
    16441 ctcgccgccg gtcgtgacga tccgctgcgt gtcggtgctg ctggggacgt gcacgacggg
    16501 cttgtccgcc gggctgtcca gcttgacctt gaacgtcggc ttcaccccgg tcgggatgac
    16561 cttgacgttg agcgccttgc cgtcggccgg cgtccgcagc tcgacggtcg tcttgccgtc
    16621 ttcgagggtg gcctggtcga gctcgacggt caccggcacg tcggcgacga acttgccgtc
    16681 ggccttggcg atgttcaccg cccagtcgcc cggggagccg atcagctgct ccttctcggg
    16741 cgcgatcacc ttcgccgtcc acgggccgcg gttcgcctcg gcgtcggcgc ggagcctggt
    16801 caccgagtct ctggcgggcg cgggcagcgc gtcgaagtgg aactgctcgt tgtaggcgat
    16861 gtggcggaag tcgttgttcg ggtcgagcga gatcttgccg tgcgggtacg ccgtccacga
    16921 gtgcaggagg tgcgccaggg cggcggcctc gtccacggac gggttggtcg tgtagcggag
    16981 caggaggtag gagatgttcg cggcgacgtc cggggcgagt gcctcgcccg ccttcgtgcg
    17041 gagttcgtcg ccgggcttgt actcctccgt gctgtcgggc gcgagcagcg agtactcgac
    17101 gcaccagacg tgcttgccct gccagatgta ggacccgagc cagtcggtgg tgccgggttt
    17161 gccccggtac ccctgggcgg gtgtggtgta gccgatgccc tcctggacct gggcgtcgga
    17221 tgtagcggga acggcgagca gggccacacc ggcggcgagc accgcgccgg cgagtcgtct
    17281 ccaccccata gttatgaacc tgacccctcg ggcatgtccg ggaagagcgg cggaagagct
    17341 tgcggaagag ctgtcgcgag cttgcggaag agctgtcgcg agcttgcggt ggagctgtgg
    17401 tcgagctttg cggtggagct gtgggcgagc ttgcggtgga gctgtggtga gtgtctcggt
    17461 agagctgtgg cgagtgtctc gggggtgcgg tgtcgagtgt ctcgggagtg cgtgggcgag
    17521 cggtggggag tgttgcgggt ccccgggaag agttgcctgg ggcagcctta cgggtgggct
    17581 ccgctgtgga caagcctcca gcggggtggg ctttccgact acgctccgca gcgtggggtg
    17641 tggattcgag atcgacagcc cgagtaaagt cagttttacc cgacgggaac cgatcgactc
    17701 gtgtggtcgt tgaaccccgt gacggcgtca aaacgccaca ggaggacgag gtgcgtacca
    17761 ccagcaaccc cgcgttccgc aacctgccga ccagcggcgg ttccgggagc tacgcgggct
    17821 tcggccagcc gtacgaggcg cagcagtacg gcggctacca gagtgcgccg ccgaccaccg
    17881 gcgagcgccc catcaccatc gacgacgtgg tcaccaagac cgcgatcacc ctggccacga
    17941 ccctggccac cggtttcatc tcggcgtggc tggtgctctc cggccaggcc aagccgctga
    18001 cgttgatgct gccgggtctg atcatcggcc tggtcgtgtc gctgatcatc atcttcaagc
    18061 gcaccccgag cgcgccgctg gtgctgatct acgcggcggc cgagggcgtg ttcctcggtg
    18121 cgatcaccgg tgtgttcgag ggcatgttca agggcatcgc ctggcaggcc atcctcggca
    18181 cgttcggcgt gttcatcgcc atgctgatcg tctacaagac gggtgcgatc cgcgtcacgc
    18241 cgcgcctgac gaagtggatc atcggcgcga ccgtcggtgc cgccgtgctg atgctcggca
    18301 acctggtgct cggcctgttc ggcgtgaacg tgggcctgcg cgacggcggg acgctcgcca
    18361 tcgtgttcag cctcgtggtg atcggtatcg cggcgttcaa cttcctgctg gacttcgagg
    18421 ccgccaacga gatgatccgc tcgggcgtgc cggccaagtg ggcctggtgg gccgcgttcg
    18481 gcctgatgac cacgctggtg tggctgtacc tggagatcct gcgcctgctg tcctacctgc
    18541 agcgcgactg acctgcgggg tctggttgca cggagggcgt ccggcttgtg ccgggcgccc
    18601 tctttcgtgt gtcgtggcgc gccggttgtg gcgggtggcg cgccgggccg tgtaggtgac
    18661 gcgcggatct gtggatcggt tgagtgccgg ccgtgccgag ccgcgccgcg ccgggtgtcg
    18721 agccgagccg cgtcaggggg gaagcgctga aggaagcaaa gcgaaaagag tcctcgccgg
    18781 acgggcgagc cgccaaggat gacgggcagt gcggtgggcg tcgtgtcatc cccgtatggc
    18841 ccggtcggag acaaccaccc ttgagcaggt agtgcaagcg aagggcgtgc ttgcactacc
    18901 tgctcaagcg cggttcgctg gcgcgcgggc cacacgggga tgacacgacg cggtggggcg
    18961 gttgttcgct tcagtcccgc catgtgtttc ccgctgttgt cgggtcttcc ttcggcagtt
    19021 ccgagccgac cttgatcagg cagggcacgc acaacgggcc gttgggttct cgcaacaggt
    19081 gttccggggg gaccgagtgc gtgcacgcgg cctcgaagta cgcctctgac ggctgggttg
    19141 acgggaatgc gtggcacagc gagtcgtacc cgctgtgcca ccacacgtac ggcatctggt
    19201 gtcgacctcc actactcata ggtagggacg tcggctcggg ctcgttgtga cgcgtgtcag
    19261 ctcaaccgct cgatcaccat cgccatgccc tggccgccgc cgacgcacat ggtctccagg
    19321 ccgaactgct tgtcgtggaa ctgcagcgag ttgatcaggg tcgtggtgat ccgcgcaccg
    19381 gtcatgccga acgggtggcc gacggcgatc gcgccgccgt tcacgttcag ccggtccagg
    19441 tcgatgccca ggtcgcggta cgacgggatg acctgcgcgg cgaacgcctc gttgatctcg
    19501 accaggtcga tgtcgccgat cgacaggccg gcgagggcca gggcgcgctt cgacgcctcg
    19561 accgggccca ggcccatgat ctccggcgac agcgcggaca cgccggtcga cacgacgcgg
    19621 gccagcgggg tgatgccgag ttccttcgcc ttggtgtcgc tcatgaccac cagggccgcc
    19681 gcgccgtcgt tcaatgggca gcagttaccg gcggtgatcc tgccgtcggg gcggaacacg
    19741 ggcttgaggc cggacacgcc ctcgtaggtc acgccggggc gggggccgtc gtcggtcgac
    19801 acgacggtgc cgtccgggag ggtcaccggg gtgatctcgc gggcccagaa gccgttcgcg
    19861 atggccttct ccgccaggtt ctgcgaccgg acgccgaagt ggtccatgtc ctcgcgggtc
    19921 acgcccttcg cgagggccag gttctccgcc gtctggccca tggcgatgta gacgtccggg
    19981 acgtcgccgg tcgtgcgggg gtcggtccag ccggtcgcgc cctgctcggc ggtggccttc
    20041 gtgcgggcct cggcgtcggc gaagaccggg ttgtgggtgt tgggccagct gtcggagctg
    20101 ccgcgcgcga agctggacac ggtctcgacg ccggcgctga tgaagacgtc gccctcgccc
    20161 gccttgatcg cgtgcagcgc catccgggtg gtctgcacgc tggacgcgca gtacctggtc
    20221 acggtggtgc cgggcagggt gtcgtggccc gccagcacgg acaccacgcg gcccaggttg
    20281 aagccctgtt cgccgcccgg caggccgcag ccgagcatca ggtcgtcgat gtcgtgcggg
    20341 tcgagctgcg gcaccttcgc cagcgccgcc ttgagcacct gcacggtcag gtcgtcggcc
    20401 cggacgtcct tgagcgagcc cttgcccgcg cgtccgatgg gcgaccttgc tgcggagacg
    20461 atgacggcct caggcattac ggaactcctt tgtttcgccg caacgttgcc ttgagcctag
    20521 ttaacgcctg ttcagcccgg ctaccactcg tgacgcaggt cgtcgtggtg ggtgagcacc
    20581 gcttcgtaca gcggggccag caggatcgac gtcgcggcct cgtagccggc ggcgctgggg
    20641 tggaactggt cgcggctgaa gtagtcccgg ctccgggtgg tgaactcggc ggccaggagg
    20701 tcgccgagcg cgaccgggac gccgccggcg tcgaggaccg cttggcgctg ggccctggcg
    20761 agccggtggc tgtactcact ggcgaccgcg cgcagcggct gcccgatggg gcggatggct
    20821 cccaggtcgg ggcacgtccc gacgaccacg ccgatgcccg cgtcgcgcag cctggccgtc
    20881 tgggtgccca gggtggccgc cgacctcggg atcggggtgc gggtggtcac gtcgttcgcg
    20941 ccgatgatca ccagcgccac gtccggcggg tcggtgacca cgcggtcgac ctgagaaggc
    21001 aggtcgtcgg tcgtcgatcc gctgatggcg taggtctcca ggcggatcgg ggtcgcggtc
    21061 tcctcggcga gtgcccgcgc cagcaggacg ccgggcagtt cctcgggggt gtccacgccc
    21121 agcccggcgg ccatcgagtc gcccagcacg gcgaacctga tgggccggcc cgggtggtcg
    21181 ccgtagacgc cgtcggcgcg caacgggggc gcgtcgggca cgccgatgat cacccgcgcc
    21241 cgcctggact gcgtcgtgaa cagggcgtac gccacgccgg tcagtccgcc cgccgcgagg
    21301 cccgccgccg cgatgagccg ccaccacttc accccggtca ccctagggcg gatcggccac
    21361 caggacgcgc gggccgcgcc cgtccgcgag tcgcgcgggc cgggcgccgc agcaagtacg
    21421 ctcggtccgt catctcgcac ggtgggaagg gaccttcggt ggagtacgtc gagagcgtcg
    21481 tcgacctggt cggcaacacg ccgctggtca agctgaacgc ggttgccgag gggctccggc
    21541 cgctcgtcct ggccaaggtc gagtacctca acccgggtgg cagcgtgaag gaccggatcg
    21601 cgctgcggat ggtcgaggcc gccgagcgct ccggcgagct caagccgggc gggacgatcg
    21661 tggagcccac ctcgggcaac accggcgtcg gcttggcgct ggtggcccag cgcaagggct
    21721 acaagtgcgt gttcgtctgc ccggacaagg tcagcgtgga caagcgcaac gtgctcaagg
    21781 cctacggcgc cgaggtggtg gtgtgcccga cggccgtcgc gcccgagcac cccgactcct
    21841 actacaacgt ctccgaccgg ctggtcgccg agatccccgg cgcgtggaag cccaaccagt
    21901 actcgaaccc ggagaacccg gccagccact accacggcac gggcccggag ctgtggcggc
    21961 agaccgaggg ccggatcacc cacttcgtgg cgggcgtcgg caccgggggc acgatctccg
    22021 gcaccgggcg ctacctcaag gaggtg
//
