LOCUS       NC_019693              23246 bp    DNA     circular CON 07-JUN-2024
DEFINITION  Oscillatoria acuminata PCC 6304, complete sequence.
ACCESSION   NC_019693
VERSION     NC_019693.1
KEYWORDS    GSC:MIGS:2.1; RefSeq.
SOURCE      Oscillatoria acuminata PCC 6304
  ORGANISM  Oscillatoria acuminata PCC 6304
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Oscillatoriaceae; Oscillatoria.
REFERENCE   1  (bases 1 to 7689443)
  AUTHORS   Gugger,M., Coursin,T., Rippka,R., Tandeau De Marsac,N.,
            Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C., Tapia,R.,
            Davenport,K., Daligault,H., Erkkila,T., Gu,W., Munk,A.C.C.,
            Teshima,H., Xu,Y., Chain,P., Chen,A., Krypides,N., Mavromatis,K.,
            Markowitz,V., Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G.,
            Pagani,I., Pati,A., Goodwin,L., Peters,L., Pitluck,S., Woyke,T. and
            Kerfeld,C.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Finished chromosome of genome of Oscillatoria acuminata PCC 6304
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7689443)
  AUTHORS   Gugger,M., Coursin,T., Rippka,R., Tandeau De Marsac,N.,
            Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C., Tapia,R.,
            Davenport,K., Daligault,H., Erkkila,T., Gu,W., Munk,A.C.C.,
            Teshima,H., Xu,Y., Chain,P., Chen,A., Krypides,N., Mavromatis,K.,
            Markowitz,V., Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G.,
            Pagani,I., Pati,A., Goodwin,L., Peters,L., Pitluck,S., Woyke,T. and
            Kerfeld,C.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JUN-2012) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B310, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Oscillatoria acuminata PCC 6304
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: USA
            environment                       :: Missing
            num_replicons                     :: 3
            ref_biomaterial                   :: PCC 6304
            biotic_relationship               :: Free living
            trophic_level                     :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            sequencing_meth                   :: WGS
            assembly :: Newbler v. 2.3 (pre-release), VELVET v. 1.0.13, Parallel
            phrap v. 4.24 SPS
            finishing_strategy                :: Finished
            GOLD Stamp ID                     :: Gi04162
            Funding Program                   :: DOE-GEBA 2009
            Gene Calling Method               :: GenePrimp, Prodigal 1.4
            Isolation Site                    :: soil
            Isolation Comments                :: isolated by MB Allen
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram-
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Finished
            Current Finishing Status          :: Finished
            Assembly Method :: Newbler v. 2.3 (pre-release), VELVET v. 1.0.13,
            Parallel phrap v. 4.24 SPS
            Genome Coverage                   :: 30x
            Sequencing Technology             :: 454/Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000317105.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 01:39:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,147
            CDSs (total)                      :: 6,067
            Genes (coding)                    :: 5,990
            CDSs (with protein)               :: 5,990
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 34 of 77
            Pseudo Genes (incomplete)         :: 37 of 77
            Pseudo Genes (internal stop)      :: 20 of 77
            Pseudo Genes (multiple problems)  :: 12 of 77
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:52:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1973512
            Orig. end                         :: 1996758
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003607.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4086915
            Source DNA and Organism available from Cheryl A. Kerfeld
            (CKerfeld@lbl.gov)
            Contacts: Cheryl A. Kerfeld (CKerfeld@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23246
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="4"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23246
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23246
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13246](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13246)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     CDS             complement(466..564)
                     /gene="allorf_1973978_1974076"
                     /locus_tag="allorf_1973978_1974076"
                     /protein_id="allorf_1973978_1974076"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRIAPTDIKGIRQSTMPSGPDSLQESERKPCY"
     CDS_motif       complement(508..564)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRIAPTDIKGIRQSTMPSG"
                     /locus_tag="allorf_1973978_1974076_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(466..507)
                     /prepeptide="core"
                     /locus_tag="allorf_1973978_1974076_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.90"
                     /molecular_weight="1515.6"
                     /monoisotopic_mass="1514.7"
                     /core_sequence="PDSLQESERKPCY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRIAPTDIKGIRQSTMPSG"
                     /leader_location="[507:564](-)"
                     /alternative_weights="1533.7"
     gene            complement(599..3394)
                     /locus_tag="OSCIL6304_RS30660"
                     /old_locus_tag="Oscil6304_1606"
     CDS             complement(599..3394)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018449.4"
                     /locus_tag="OSCIL6304_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1606"
                     /product="SBBP repeat-containing protein"
                     /protein_id="WP_015147950.1"
                     /transl_table=11
                     /translation="MMMDDTNSTAALGLIETGLEVNFGLISGVENSQPSGWDESVLISG
                     FNPAVAPLNAPLVPGESDLGILGSDRLLLDEAMATPDLAFPQSQGDPLVGFTTPIGEIN
                     PSFGNLPLSFIPLENGPGTPQFQVAGAGHTIQFAQDGLLLTSSQQTPEGPVNATVQLQF
                     IGANSHPEISGLNPLPGVANFFMGNNSSQWVSNVPTYSGVSYNELYPGIHLFYNGIEGQ
                     LKRDFIVEPGVNPDQIRLNYSGITGLDIREDGALILQTALGELIETAPVIYQEIDGNRI
                     AISGGYRLLGDGLVGFEIGDYDPNYTLVIDPVLEYSSYLGGSQSDRGFDVALDQVGNIY
                     IAGITQSANFPNLGGLQSANAGESDVFITKLDPTGTTILFSTYFGGSGTEASEEGANVS
                     LRVDNAGNIYLSGNTNSTDLPTTAGTIQTALSGEQDTFVAKFNNSGTELIYSTYLGGTG
                     IETNWDMTLDNQGQIYLTGVTSSTDFPLVNAAQNTFGGIGAFSFGDVFVSKLNPTGTEL
                     VYSTYLGGSEDDGALAIAVDESGSAYVAGYTASPNFPISPGAFQTQFNGAFLDAFVTKL
                     DPSGSTIEYSTYLGGSGEVDGDYITGIAVDNEGNAYLAGYTDSEDFPTTPGAFQPSFGG
                     GLYDSFVTKLNPTGTGLVYSTFLGGSEMDFSGPIALDSLGNVYIAGNTDSPDFPTVNAL
                     QPSFSGVADAFITQLNPQGSEAIYSTFFGGSQRDFILGMVPDDAGNIYVTGGTRSPDFP
                     ITTGAIQSAKLEEALDGFIAKISNPNLTVSPAYQTSIEFIRNLQLDLQSLFFDEGFYLA
                     TNPDVATAVNNGSVASAFVHYTNFGQFEGRNPSQLFDEQAYLAQNSDVSAAKTSGGIDS
                     GFAHFIQFGFLEGRAPISLTFNPGFYLQTNPDVAAAVNQDIFPNALAHYLIFGHREGRR
                     I"
     gene            complement(3545..5461)
                     /locus_tag="OSCIL6304_RS30665"
                     /old_locus_tag="Oscil6304_1607"
     CDS             complement(3545..5461)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024829.4"
                     /locus_tag="OSCIL6304_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1607"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_052315709.1"
                     /transl_table=11
                     /translation="MLSDPNQNLLPIAKSDEFLPPLSGWNTLGGLFLVGTVAAGVTMAA
                     IAEYPITVKVPATIRLTGEVKIVQAAVEGTIKRIEVRENQEISQGSVIAILDDSQLQIQ
                     KVQNENNLQNIQQQIAQINAQIQAIDRQMMAETERSTRTVASGQAELSRQQRDYQDRQA
                     NTILEVEEALANLRVIEQELAQARSELKAELATLNQLISSLNTGVFQASQYRMDFNENL
                     DNIKTLSKQQFEQIAQDSPVESAANVRKERENLSQMQSELRSAQADLTGIERALDAAQL
                     KRDRHQNLLDTGAISRQVFEEFQLLFDQQTQALAAQTARIESYQTGMKQQEQVIAGAEA
                     RLHNELAEVQLIVEQQKQAVAAQKARVETQKQAIAREEQAVAAAQSKVQRARTALNPND
                     SPVAIAREQIEGDQATGLLRIAELTQQRAALIQQKIDQDNQGKFLEQELEQIQRQIQQK
                     VIEAPEFGKILQLNLRNPGQVVRIGEEIAQISPIQAPLVAKAWVPSSEISQVETGQNVH
                     LRIEACPHSEYGTLLGKVSAISPDTISGDNRSFNSSLNQPKLNSSVANSYYETTIELQQ
                     IYLTQKSRMGANHSESSPVNSGERNDQHCSIQPGMQARADIVSKTETFLNFILRTSRIK
                     LGN"
     CDS             complement(5455..5544)
                     /gene="allorf_1978967_1979056"
                     /locus_tag="allorf_1978967_1979056"
                     /protein_id="allorf_1978967_1979056"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MFIRLLNRKRTVIQADRRLILVERLKKSC"
     CDS_motif       complement(5500..5544)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFIRLLNRKRTVIQA"
                     /locus_tag="allorf_1978967_1979056_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5455..5499)
                     /prepeptide="core"
                     /locus_tag="allorf_1978967_1979056_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="1711.1"
                     /monoisotopic_mass="1710.0"
                     /core_sequence="DRRLILVERLKKSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFIRLLNRKRTVIQA"
                     /leader_location="[5499:5544](-)"
     misc_feature    5607..5621
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 20.81"
                     /tool="antismash"
     gene            complement(5659..5865)
                     /locus_tag="OSCIL6304_RS07960"
                     /old_locus_tag="Oscil6304_1608"
     CDS             complement(5659..5865)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007358547.1"
                     /locus_tag="OSCIL6304_RS07960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1608"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_015147952.1"
                     /transl_table=11
                     /translation="MFENIDVVRAWKDSDYRDSLTQDQRDRLPENPAGLIELSDEDMSS
                     IAGGHPTVRPTTCSCCGSAALTA"
     CDS_motif       complement(5722..5865)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MFENIDVVRAWKDSDYRDSLTQDQRDRLPENPAGLIELSDEDMSSIAG"
                     /locus_tag="OSCIL6304_RS07960_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(5659..5721)
                     /prepeptide="core"
                     /locus_tag="OSCIL6304_RS07960_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-0.90"
                     /molecular_weight="1825.1"
                     /monoisotopic_mass="1823.9"
                     /core_sequence="GHPTVRPTTCSCCGSAALTA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFENIDVVRAWKDSDYRDSLTQDQRDRLPENPAGLIELSDE
                     DMSSIAG"
                     /leader_location="[5721:5865](-)"
                     /alternative_weights="1843.1"
                     /alternative_weights="1861.1"
                     /alternative_weights="1879.1"
     misc_feature    5923..5938
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.4"
                     /tool="antismash"
     misc_feature    complement(5923..5941)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.87"
                     /tool="antismash"
     misc_feature    complement(5926..5941)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.97"
                     /tool="antismash"
     gene            complement(6075..8003)
                     /locus_tag="OSCIL6304_RS07965"
                     /old_locus_tag="Oscil6304_1609"
     CDS             complement(6075..8003)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="OSCIL6304_RS07965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1609"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_052315710.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 7.7e-10, bitscore:
                     37.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLIPLPGIIHWKGNHWVVLYGRRGQKYVVADPAFGLRYLSSQ
                     EITAGWMNNVMLLLETRSDFYQLLDDRGKMSGYRRLLERLWHHRSLLGRSLLFNLTIGC
                     LSLTTPFLLQVLTDDVLVRGDTQLLNVMIKAVLVMHIISSGLNLAQSHLVTYLAQRLEL
                     DLMLEFGRAILSLPLTYYETHRSGEVSSRLLDIREVNQLISRVGLILPSQLLIAVASVT
                     FMVIYSRVLTLVALGIAAVIALGMVCFLSYLQQRTRNLLAFAAETQGILVETFKGALAL
                     KTIQAAPQLWAEFQGRYGRQAHLTFRVMNAVIVIQVFSGFLALSGETLLLWMGSHLVIN
                     QQLSIGQLLGFNALNLNLILLMTSLVSFVPQVTRTQAATERLMDVIEAQSEPNEEIKPT
                     AKLAADAPVICQNLTFHHPGRVELLKDFSLTIPGGKAIAIIGKSGCGKSTLAKLIAGLY
                     QPSSGTIRIEPYNLTDLSWDCVRQQVVLVPQDAHFWSRSILDNFHLGSLPVSFEQIVTA
                     CQIAQADEFISKLPNKYHTILGEFAMNLSGGQRQRLAIARGIVTDPPLLILDESTAGLD
                     PVSEADVLDRLLSSRHQKTTILISHRPRVIERADWIIWLDEGRVKLQGTPGDILAQSGD
                     RCDFLIP"
     misc_feature    8000..8014
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.71"
                     /tool="antismash"
     gene            complement(8077..9654)
                     /locus_tag="OSCIL6304_RS07970"
                     /old_locus_tag="Oscil6304_1610"
     CDS             complement(8077..9654)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015147653.1"
                     /locus_tag="OSCIL6304_RS07970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1610"
                     /product="IS1182 family transposase"
                     /protein_id="WP_015147653.1"
                     /transl_table=11
                     /translation="MRPPLWHPPVELSDSEQVIINRIKKAKLFTFLRLNRLFIFDDEFQ
                     EELNTIFKDSTMGNCPVAPAQLALATILQAYMGISDEEVIEELVMDLRWQLALNCLNCE
                     KPPFSKATLIRFRSALIKKGFDQRLIDRTVDIAKLKGGFGSANLRAALDSSPLWGAGKV
                     EDTYNLLGHALRKALSIIASQQGWGLAEIANEAGADFVNSSSLKAALDLNWDDPAESQK
                     ALSTILKSLNSVEEWIQQQSNPDEIEEAQAPLQVARLIESQNVTLDTMGVPKLAKGVAK
                     DRRISIEDPDMRHGRKSRSQKINGYKRHILKDLDIGVIRAVAVTRANTPEAAATVDLEV
                     DLKRQQVQLNELHIDRAYLSSHWVKERSEQLQIFCKAWPVRNSGRFDKNAFVFDWDNQV
                     ISCPNQVIMPFEPGKIVHFPKPECAACPLRERCTTSKNGRSISIHPDEGLMQELRQRQS
                     TSSGRAQLRERTSVEHSLAHVGQWQDKRARYIGQRKNLFDLRRVAVVHNLHVIARMNEV
                     LPIQQAAL"
     gene            complement(9729..9965)
                     /locus_tag="OSCIL6304_RS07975"
     CDS             complement(9729..9965)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015377.4"
                     /locus_tag="OSCIL6304_RS07975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_044194733.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.2e-17, bitscore:
                     60.4, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYPVILQHNEEDCGAACLATVSSAYGKKFSIKRTREAAGTGQL
                     GTTLLNLKQGAQTLGFNARGVRVPLGRRFSTRA"
     misc_feature    9956..9969
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.93"
                     /tool="antismash"
     misc_feature    complement(9957..9970)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.3"
                     /tool="antismash"
     misc_feature    9957..9971
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.76"
                     /tool="antismash"
     gene            complement(10001..13246)
                     /locus_tag="OSCIL6304_RS07980"
                     /old_locus_tag="Oscil6304_1611"
     CDS             complement(10001..13246)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="OSCIL6304_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1611"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_015147953.1"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-114, bitscore:
                     382.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.7e-68, bitscore:
                     228.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEENSQRVQWYRGIPLRERIASGDRPKAGSTPLGDRRLQRWRSQ
                     TPFNNDIYFAQRLASDGLTEPEFQQLLEESRETLAHQFPEPPNWIKTLSDILSTYPFSA
                     LSETGNLSDTQSGVSGFLTLFSPLIAWGRSCLQEKLQTLLSIHSPDCINSQTIAAILYE
                     PLPKELLWMSTRTLVLELNVARIQGKLSGNSSAERFAQFIQQLQQPEMALALWTEYPVL
                     TRQVLNSIQGWITVSYEFVERLCQDWPRIIQQFSRDSEPGGLVHLNSNAGDSHNGGRSV
                     AIAEFSSGFKLVYKPRSLSIDIHFQNLLNWLNKQGNYPPFPILNVLNCGEYGWVEYVTA
                     QPCDTAAQIERFYQRQGGYLALLYALQATDFYSNNIIAVGEQPILVDLESLFHPRYSQL
                     EGFNSDCLAERELDWSVLSVGILPMNLWGNQGYGGIDISGLGNSGSPMTPDAIPTWQGV
                     ATDEMKISRKAVQLPPDLNRPTLNGASVKLEDYTAAIITGFTEIYRVLVKNRDNLVGES
                     GLFNTFAEDEIRVVLRATRTYGLLLQEGFHPDLLRDALDRDRLFDKLWVEVPNFPSLAR
                     VIPAEIQELWQGDIPRFTTQPNSRDLKSGQGEIISDFLPESALDSVRLHLQGMDETNLE
                     RQVGLIRAAIATVIRSPDAIQWPSYPMRVPETRPSSQTYLKAACAIGDRLEQVALCQNQ
                     MADWIGLTWIREGELAIRRVDIHLYDGLPGISLFLAYLGNITQEVRYQNLAVAALNYWQ
                     VCLEKELKPGESIGGFTGFGSAIYSLSHLAIQLNQPQLISVAREWLDYLPEAILQDEEW
                     DIISGSAGCILSLLSLYAVAPDSQILDVAIQCGDRLIIGARPQETGIGWIPSAIRSKRP
                     LTGFSHGAAGIAYALLELAAVTQLERFQKAAIAAIAYERSVFDPNARNWPDFREFDHSP
                     RVGNLGPLAWSHGAPGIGLARLYALQHQDDPQIRQEIYTALDITCDRGFGQNHSLAQGD
                     LGNLEFVLQASLTLGEPQWHSHLHTGGSILESIQSEGWLCGTPLGVETPGLMSGLAGIG
                     YGLLRLATPETVSSVLALRPPILSPQSDDSEGL"
     misc_feature    13354..13369
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.52"
                     /tool="antismash"
     misc_feature    complement(13356..13370)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.47"
                     /tool="antismash"
     misc_feature    complement(13357..13372)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.17"
                     /tool="antismash"
     gene            13570..14163
                     /locus_tag="OSCIL6304_RS07985"
                     /old_locus_tag="Oscil6304_1612"
     CDS             13570..14163
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014389.4"
                     /locus_tag="OSCIL6304_RS07985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1612"
                     /product="YggT family protein"
                     /protein_id="WP_015147954.1"
                     /transl_table=11
                     /translation="MNPDNSRPDRDNPIPGEPLTPPNPGIPRGDRAYSPSEQSRNPVED
                     LRREQERHIQNLGELRQEEARLSRQLQELRQQEEHIHRRIEGIQLEEEERRIAEVRRRL
                     ALSKTNQVIYYLMGALGVLLVLRILLRLLGANPDNQFAGFIYALSSPFVTPFETLFTTP
                     TFGNSAFEFNALIAIAVYGLLTWLVIRLLELIWT"
     gene            complement(14274..15848)
                     /locus_tag="OSCIL6304_RS07990"
                     /old_locus_tag="Oscil6304_1613"
     CDS             complement(14274..15848)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006670041.1"
                     /locus_tag="OSCIL6304_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1613"
                     /product="NAD(P)H-quinone oxidoreductase subunit N"
                     /protein_id="WP_015147955.1"
                     /transl_table=11
                     /translation="MNFANLAAQLNAGIILPEGIVIITLLVVLVYDLIVGRESLKVTPY
                     MAIAGLLAALVALVYQWDASDPISFLGGFNGDSMSVIFRGIIALSAVVTVLMSIRYVEN
                     SGTAMGEFLMILLTATLGGMFLSGADELVMIFVSLETLSISSYLLTGYMKLDPRSNEAA
                     LKYLLIGAASSSVFLYGMSLLYGLSGGETRLSAIASGITASGTGPSIGLVISLVFVIAG
                     ISFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAGFALAIRLLTTAFPLVEEQWHFV
                     FTALAILSMVLGNVVALAQTSLKRMLAYSSIGQAGFVMIGLIANTDAGYASMIFYLLVY
                     LFMNLGAFTCLILFTLRTGTDQISEYAGLYQKDPLLTLGLSICLLSLGGIPPLAGFFGK
                     IYLFWAGWQAGLYGLVLLGLLTSVVSIYYYIRVVKMMVVKEPQEMSEAVKNYPEISWNL
                     RGMRSLQVGLILTVIATSLAGILSNPLFTLANNSVSRTSMLQASMGKTVPVATLTSPAD
                     LDASNTP"
     gene            complement(16017..16151)
                     /locus_tag="OSCIL6304_RS36345"
     CDS             complement(16017..16151)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OSCIL6304_RS36345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_284690287.1"
                     /transl_table=11
                     /translation="MTLTQAEETGGKNGEGGEEIADWIGAFSPVAMGFRRYSEQQPVG"
     gene            16570..19233
                     /gene="topA"
                     /locus_tag="OSCIL6304_RS07995"
                     /old_locus_tag="Oscil6304_1614"
     CDS             16570..19233
                     /EC_number="5.6.2.1"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003917 - DNA topoisomerase type I (single
                     strand cut, ATP-independent) activity [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="topA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006619329.1"
                     /locus_tag="OSCIL6304_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1614"
                     /product="type I DNA topoisomerase"
                     /protein_id="WP_015147956.1"
                     /transl_table=11
                     /translation="MSTLVIVESPTKARTIRNFLPNDYRVEASMGHVRDLPSSADEIPE
                     QVKGEKWAQLGVNVEADFEPLYVIPKTKQKVVKTLRDALKQADELILATDEDREGESIS
                     WHLQEVLKPKVPIKRMVFHEITREAIRDALNNCRTIDYQLVHAQETRRILDRLVGYTLS
                     PLLWKKIASGLSAGRVQSVAVRLLVQRERQRRAFRQGSYWDLKARLVQAKTPFETKLVT
                     LGDRKVATGSDFDESTGQIIAGRNVVLLNEEQARALVTQITGKPWQVAKVEERPTTRKP
                     SPPFTTSTLQQEANRKLRLSARDTMKIAQSLYENGYITYMRTDSVHLSEQALTAARTCV
                     AEMYGKEYLSPKPRQYATKSKGAQEAHEAIRPAGSSFRTPQQTPLSGRELQLYDLIWKR
                     TVASQMADARQTIVAVDLQVENAGFRSSGKRIDFPGFLRAYVEGSDDPDAALEDQEVIL
                     PALKVGDRPNCQNIEAVGHETQPPARYTEASLVKTLESEGIGRPSTYASIISTIIDRGY
                     SILKGNALVPTFTAFAVTDLLEKYFPELVDPGFTAKMERTLDEISTGEAAWLPYLQKFY
                     LGENGLETQVKQQESAIDPNQARSVELENLDAKVRIGRYGPYIEADNGDGVVTASIPKD
                     LTPSDLDPEQVQLILKQKTEGPDQLGTDPNTGLPIYILIGKYGPYVQLGEATEENKKPK
                     RASFPKGVTAENLTVEQAVGLLALPRTLGVHPENGGKIQASLGRFGPYVVCDRGKEEGK
                     EYRSLKAGDDVLSITLPRALELLAEPKKGRSSKTSKAKEPLRELGKHPADDEPVNVYDG
                     PYGPYVKHGKTNASVPEGTTVEDVTLAQAVELLAAKASTSKSKSKTSSKSKTSSTKSKT
                     GTTKKKSTTSTAKKKS"
     CDS             complement(19324..19413)
                     /gene="allorf_1992836_1992925"
                     /locus_tag="allorf_1992836_1992925"
                     /protein_id="allorf_1992836_1992925"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCICRGALGSASTKGASIVRLQEITNFCH"
     CDS_motif       complement(19366..19413)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MCICRGALGSASTKGA"
                     /locus_tag="allorf_1992836_1992925_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19324..19365)
                     /prepeptide="core"
                     /locus_tag="allorf_1992836_1992925_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.30"
                     /molecular_weight="1523.7"
                     /monoisotopic_mass="1522.8"
                     /core_sequence="SIVRLQEITNFCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCICRGALGSASTKGA"
                     /leader_location="[19365:19413](-)"
                     /alternative_weights="1541.8"
     gene            19551..20216
                     /locus_tag="OSCIL6304_RS08000"
                     /old_locus_tag="Oscil6304_1615"
     CDS             19551..20216
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015178278.1"
                     /locus_tag="OSCIL6304_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1615"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_015147957.1"
                     /transl_table=11
                     /translation="MITTAPQNYRNLLGEKRVSLRGLTWQSYQQILHALPQSRSARLTY
                     DCGILEITMPLESHEFGLRLIEVFIRILVFEMGMKIKTMGSTTMDREELDRGAEPDCAY
                     YIQNQSRVAGRTVDFTTDPPPDLVVEVDITHTDIDKNRLYAAMEVPEFWRYNGREWRIY
                     QLAEGIYQECDRSPTFTWVEKEYLYEFLEQAQQDEMEAERAFRERVRANLSSQKKTEE"
     gene            20336..20950
                     /locus_tag="OSCIL6304_RS08005"
                     /old_locus_tag="Oscil6304_1616"
     CDS             20336..20950
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018397941.1"
                     /locus_tag="OSCIL6304_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1616"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_015147958.1"
                     /transl_table=11
                     /translation="MTSTLSQRTYTVDEYLAQEIASQDRHEYRNGALVLMAGGTPNHNQ
                     ITLNLAGSLNFVLRRQPYRVFIADQRLWIPDRRIYTYPDVMVVGQPIELQEGRKDTITN
                     PIVIAEVLSQSTRSYDKDEKFAAYRSLASFREYLLIDQYTAHIEHYTKTEGQAWLFREY
                     DGLETTISFQSFDFSLSLADLYDKVDFAPAEVKVESDLELS"
     misc_feature    complement(22872..22890)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.96"
                     /tool="antismash"
     misc_feature    22935..22953
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.79"
                     /tool="antismash"
ORIGIN
        1 tcgttggacc cggcctcgta ttgcgaaccg cctgctgtgc tacttcatcc caaaacggca
       61 cgctccggga ataggcgatg cggccttccc cttctccata agtgagataa tgatgtagtc
      121 cgctgctaaa tcctgtcacc gggtcgatcg cctccgccac atccggattg tgttgttgat
      181 agaactgttc atcaaataaa acactcggat tccggttttc ctgttgtcca aacctcagat
      241 aatgagtcag tcctgaatct aataattgcc ctgcaaccgc agcagcaaca tcgggatatt
      301 gttctaaata ataggcttca ttataccagg cactcggagt tcggctttct ccctgacccc
      361 attggataaa atgctctaat ccagagttga atcctccctg ggttacggct aaatttacat
      421 ctggattttg ttgtaagtaa tagctttcat cgaataagtc gtcaattaat aacatggctt
      481 tctctctgat tcttgcagtg aatcgggtcc tgatggcatt gtggattgac gtattccctt
      541 gatatctgta ggggcgattc gcaaatcgcc cctaccattc taagatttga cctccaaatt
      601 agattcggcg accttcacga tgcccaaaaa ttaggtaatg agctaatgca ttcgggaaaa
      661 tgtcttgatt aaccgcagca gcaacatcgg ggttagtttg taaatagaat ccggggttaa
      721 aggttaaaga aattggagcc cgtccttcta agaaaccaaa ctggatgaaa tgagcaaaac
      781 cactgtcaat tcccccactg gttttggctg ccgatacatc agaattttga gccagataag
      841 cctgttcgtc aaataattga ctaggatttc ggccttcaaa ttgtccaaag ttggtataat
      901 ggacaaaggc actggctacg ctaccattgt taaccgccgt tgccacatca gggttagttg
      961 ctaaatagaa accttcatca aagaacaacg actggagatc gagttggagg ttacggataa
     1021 actcaatcga ggtttgatag gcgggagaaa ctgtgagatt ggggttgcta attttagcaa
     1081 taaatccatc cagagcttct tctagtttag cactttgaat cgccccggtt gtgatgggaa
     1141 aatcaggcga tcgcgtcccg ccagtgacat aaatatttcc ggcatcatca ggaaccattc
     1201 cgaggataaa atctcgttga ctgcctccga agaaggtgga ataaatggcc tcagaccctt
     1261 ggggattgag ttgggtaata aatgcatcgg caaccccaga aaacgagggt tggagagcat
     1321 taaccgtggg aaagtcgggg gagtcggtat tcccggcaat ataaacattt cccagactat
     1381 cgagggcgat cggtccactg aagtccattt cgcttccccc caaaaatgtc gagtagacta
     1441 acccagttcc ggtgggattg agtttcgtca caaaggagtc atataatccc ccgccaaaac
     1501 tgggctgaaa tgccccggga gtggtgggaa aatcttcaga atccgtatat ccggccagat
     1561 aagcattccc ctcattatca acagcaattc ccgtgatata atccccatcg acttcaccgg
     1621 aacccccgag gtaggttgaa tattctatcg tcgatccgct ggggtcgagt ttggtgacaa
     1681 aggcatccag aaaagcacca ttaaattgag tctgaaaagc accgggactg atgggaaaat
     1741 tcggggaagc ggtatatccg gcaacataag cgctgccact ttcatcaacg gcgatcgcca
     1801 aagcgccatc atcttcactc ccgcctaaat aggtggaata aaccaactcg gttcccgtgg
     1861 gattaagttt acttacaaat acatctccaa aggagaatgc gccgatcccc ccaaaggtat
     1921 tttgagccgc attgactaag ggaaaatccg tggaactggt gacgccagtc aggtaaattt
     1981 gaccctgatt atctagggtc atatcccagt tcgtttctat gccagttccg cctaaatagg
     2041 tggagtaaat cagttcggtt ccactgttat tgaatttggc aacaaaggta tcttgctctc
     2101 cagataaagc ggtttgaatc gttcccgctg tggtgggtaa atctgtggaa ttggtattac
     2161 cggaaagata aatattccca gcattatcga ctcggagaga aacattagca ccttcctccg
     2221 atgcttctgt gccactgcct ccaaagtaag tagaaaaaag aattgtggtt cccgtggggt
     2281 cgagtttggt gataaataca tcactttctc cggcattagc agattggagt cctccgaggt
     2341 taggaaaatt agccgattga gtaattccag caatataaat attccccact tgatctaacg
     2401 ccacatcaaa tccccgatcg ctctggctac ccccgagata actagagtat tctaacactg
     2461 ggtcaatcac tagagtatag ttggggtcat aatccccgat ttcaaacccc actaatccat
     2521 cccctagcaa gcgatatccc ccagatatgg caatccgatt gccgtcaatc tcttgataaa
     2581 tgacaggtgc agtttcaatt aattccccta atgccgtttg caaaatcaat gccccatctt
     2641 cccggatatc taagcccgta atcccactat aattgagccg aatttggtcg ggattgaccc
     2701 ctggttctac gataaagtca cgctttaact gcccttctat gccattgtaa aacaagtgaa
     2761 tgcccggata taattcgtta taactaactc cgctataagt aggaacatta ctcacccatt
     2821 ggctcgaatt atttcccatg aaaaagttag caacaccggg taaggggttt aagcccgata
     2881 tttctgggtg agaattggcc ccaataaatt gcaattggac tgtagcattg acaggccctt
     2941 cgggggtttg ttgggaggag gttaataaca atccatcctg ggcgaattga atcgtatgtc
     3001 cggcaccggc tacctggaat tgcggggttc cgggtccgtt ttctagggga ataaaactta
     3061 atggcaggtt gccaaaggag ggattaattt cgccgatggg ggtggtgaac ccgacgagtg
     3121 gatcgccttg agattggggg aatgccaagt cgggagttgc cattgcttcg tccagcagga
     3181 ggcgatcgct tcccaagatt cctaagtctg attccccggg aacgagagga gcatttaaag
     3241 gggcgactgc cggattaaac ccggaaataa gcaccgactc atcccaaccg gaaggctgtg
     3301 aattttctac cccggaaatc aagccgaaat taacctctag tccagtttca attaacccga
     3361 gtgcggcggt actattcgta tcatccatca tcatgattca gtttcctctc taagttttaa
     3421 acaaatcggc attgaatttg gataggccga tgattttata gggaattaat tttagttgct
     3481 gggtaaaaat tagcaggtat ttttaaaatt gctaataaat tcagtaacat tatcccaact
     3541 tcctctaatt tcccagtttg attcgagatg tgcggagaat gaagtttaaa aaagtttcag
     3601 ttttagaaac tatatccgcc cgggcttgca ttcccggttg aatggaacaa tgttggtcgt
     3661 tccgttctcc agaattcaca ggggaggatt ctgaatgatt agcgcccatc ctcgattttt
     3721 gagttaaata aatttgctgc aattctatgg tggtttcata ataagaattg gcgacagatg
     3781 aattcaattt cggttgattc aagctcgaat taaaacttcg attgtctcca gaaatcgtat
     3841 ccggtgaaat tgccgatact ttccccagaa gggttccata ttctgaatga ggacaagcct
     3901 caattctaag gtgaacattc tgtcccgttt ctacttgact aatctcggaa gagggaaccc
     3961 aggctttagc cactaggggg gcttgaatcg gcgaaatttg ggcaatttct tccccaattc
     4021 ggacgacttg tcctggattt ctcaagttaa gctgaagaat tttgccgaat tctggagctt
     4081 caatcacttt ttgctgaatt tgtcgctgga tttgttcgag ttcttgttcc aaaaatttcc
     4141 cttgattatc ctggtcaatt ttttgttgaa ttaaggcggc tcgttgttga gtcagttcgg
     4201 caattctcaa cagcccagtc gcctggtctc cttctatctg ttctcgggcg atcgccactg
     4261 gagaatcatt gggattgagt gcagttctag cacgttgtac tttagattgg gcggcagcaa
     4321 cggcttgttc ttcccgggcg atcgcttgtt tttgagtctc taccctagcc ttttgggcgg
     4381 ctacggcttg tttttgctgc tcaacaatca attgcacttc agctaattca ttgtgcagtc
     4441 tggcttcggc tccagcaatc acctgttctt gctgtttcat ccctgtttga taggactcta
     4501 tccgggcagt ttgggcagct aatgcctgag tttgttggtc aaataaaagc tggaattctt
     4561 caaacacttg acgagaaatt gctccagtgt ccagtaaatt ttgatggcga tcgcgcttta
     4621 actgagcagc gtctaaggcc ctttcaatcc ccgttaaatc cgcctgggcg gacctgagtt
     4681 cagactgcat ttgagataaa ttctcccgtt ctttcctgac attagctgcc gactctacag
     4741 gagaatcttg agcaatttgt tcaaattgct gtttagagag agttttgata ttatctagat
     4801 tttcgttgaa atccattcga tattgagatg cttgaaacac ccccgtattt agagaagaaa
     4861 ttaactgatt taaagtagcc aattctgctt tgagttcaga ccgagcttgg gctaattctt
     4921 gttcaataac tcgcaggttg gctaaggctt cttccacttc taaaatggta ttggcttggc
     4981 ggtcttgata gtctctttgc tgacggctga gttcagcttg gccggaagcg acagtccggg
     5041 tgctgcgctc cgtttcagcc atcatctggc ggtcaatcgc ctgaatttga gcattgattt
     5101 gagcgatttg ttgttgaatg ttctgtaagt tattctcatt ctgaactttt tggatttgca
     5161 gttgagaatc atccaagatg gcgatcactg acccttgact aatttcctga ttttcccgga
     5221 cttcaatccg ttttatggtt ccctctacag cagcttgaac gattttgact tctccggtga
     5281 gacggatggt ggccgggact ttaaccgtaa tcggatattc cgcgatcgcc gccatcgtga
     5341 cccctgccgc cactgtcccc actaaaaata agccgcctag ggtattccaa ccacttaatg
     5401 gcggtaaaaa ttcgtcgctt ttagcgatgg gaagtagatt ttggttcgga tcactcaaca
     5461 tgattttttc agtctctcca caagaatcag cctcctgtcc gcctgaatca cagtcctctt
     5521 tcggttcaga agacggatga acacaggaag aaatgctgtg gcgcattagc gccacaacaa
     5581 tagggttcta cttaagtctg gggtgttgaa atccaatttc aaaaattgga tgtgaggata
     5641 tttgcggagg attcgccctt aggcggtcaa cgcagcactt ccacagcagg agcaggttgt
     5701 gggtctgacc gtgggatgtc caccggcgat cgaagacata tcttcgtcag agagttcaat
     5761 taacccagcc gggttctccg gtaagcgatc gcgttggtcc tgagttagac tatcgcgata
     5821 gtctgagtct ttccaagccc ttactacatc aatgttttca aacatatcgg ctttcctgga
     5881 acatctccag tattgcttgt acggttccca gattatcatg agaattagaa tcattctcat
     5941 taagtttttt aacgattgct gccgaatatt attaagaatt gtcaactttt ctcaagtgag
     6001 agcgtgttcc cctggtgtcc cggttacagt gcagattcaa gaaataacag cctaccccag
     6061 cggaaactca gccgctaggg aatcaagaaa tcgcagcgat cgcccgattg agcgagaata
     6121 tccccaggag tgccctggag tttgacgcga ccctcatcca gccagataat ccagtcagcg
     6181 cgctcaatca cccgaggacg atgactaatt aaaatcgtgg ttttttggtg gcgagaggac
     6241 aacaggcgat caagaacatc cgcctcactt accgggtcga gtccggcggt ggattcatct
     6301 aaaatcagca ggggagggtc ggtgacaatt cccctggcga tcgctaatct ttgtcgctgt
     6361 cccccagaca aattcatggc aaattcccct aaaattgtat gatatttatt cggaagttta
     6421 ctaataaatt catccgcctg ggcaatttgg caagcggtga caatttgctc aaaggatacc
     6481 ggcagcgaac ccaagtgaaa gttatctaaa atagaacgac tccaaaagtg agcatcttgc
     6541 ggaaccaaaa ccacctgttg ccggacgcaa tcccaggata aatccgtcaa attataaggt
     6601 tcaatccgaa tggttcccga tgagggctga tataaaccgg caatcaattt ggctaaggta
     6661 ctttttccac aaccggactt gccaataatg gcgatcgcct tgcctcccgg tatggtcagc
     6721 gaaaagtctt tgagcaactc cactcgtcct ggatgatgaa acgttaaatt ctggcaaatc
     6781 accggcgcat ccgccgccaa ttttgccgta ggttttatct cttcattcgg ttctgattgc
     6841 gcttctatca catccatcaa ccgttccgtt gccgcctgag tgcgggtgac ttggggaacg
     6901 aaactcacca gactggtcat taacaaaatc agattcaaat tcaaagcatt aaatcctaac
     6961 aattgcccaa tacttaattg ctgattaatc accaaatgac tccccatcca aagcaagaga
     7021 gtttcccccg ataaagccaa aaatcctgaa aaaacctgga taacaatcac cgcattcatc
     7081 acccgaaaag tcaaatgagc ttggcgacca tagcgccctt gaaattcggc ccataattgg
     7141 ggcgctgcct gaatggtttt gagagccaaa gctcctttaa atgtttcgac caaaatccct
     7201 tgagtttctg cggcaaaggc caataaattt cgggttcttt gctgaagata cgataaaaaa
     7261 cagaccatcc ccaaggcgat cactgcggcg attcccaggg cgactaaagt cagaacccga
     7321 ctataaatta ccataaatgt cacggaagcc actgcaatta acaactggct ggggagaatt
     7381 aaacccacgc gagaaatcag ttgattaact tctcgaatat ccagtaaccg actagagact
     7441 tccccactgc ggtgggtttc atagtaagtc aggggtaagc tgagaattgc ccgcccaaat
     7501 tctaacatta aatcgagttc taagcgttgg gctaaataag tgactaaatg ggattgggct
     7561 aaattcaagc cgctactgat gatatgcatg actaaaactg ctttaatcat cacattgagc
     7621 aattgagtat ccccgcgaac taagacatca tcggtgagga cttgcaacag aaaaggagtt
     7681 gtcagagaaa gacaaccaat cgttaggtta aataacaaac tccggcctaa aagactgcgg
     7741 tgatgccata accgctcaag taagcgtcta tagccgctca ttttaccgcg atcatcgagc
     7801 aactgataaa aatcgctccg ggtttccagc agaagcatta cgttattcat ccagcctgct
     7861 gtaatttctt gggaggataa atagcgcagg ccaaaagccg ggtctgctac cacatatttt
     7921 tgaccccgcc gcccatacag cacaacccaa tgattgcctt tccaatgaat aattcccggt
     7981 aaaggaatca gttttttatc cacaagttct agggcgtcgg ttcagtaaaa gggcttgaca
     8041 aaaccaagca aatgtgaatc tacctgctgg actcaactac agtgcggcct gttgtattgg
     8101 taaaacctca ttcattcgag caatgacatg aagattatgg acaacagcca ctcgtctgag
     8161 gtcgaagagg tttttgcgct gtccaatata acgggcacgt ttgtcctgcc actgtccgac
     8221 atgagccaga gagtgttcta cagacgttct ctccctcagt tgagcgcgac cgcttgaggt
     8281 agattgacgc tgacgtaatt cctgcatcaa tccttcatcg ggatggatag atatgctgcg
     8341 gccattctta ctcgtagtac agcgttctct caggggacaa gcagcacact ccggtttagg
     8401 aaaatgaacg atcttaccgg gttcaaacgg cataataact tgatttggac aactaattac
     8461 ctggttatcc cagtcaaaaa caaaggcgtt tttatcaaat cgtcctgagt ttcttaccgg
     8521 ccacgcttta caaaatatct gtaattgttc ggagcgttct tttacccaat gactcgataa
     8581 ataagctcgg tcgatatgga gttcatttaa ctgaacctgt tgtcttttta agtcaacttc
     8641 taagtcaaca gtggcagcag cttctggtgt attagcacgg gttacagcca cagcccgaat
     8701 tacccctata tctaaatctt taagaatatg gcgtttataa ccatttattt tttgagaacg
     8761 gctttttcgg ccatgccgca tatctgggtc ttcaatggaa atgcgtcggt ccttagcaac
     8821 ccctttggcc agcttcggca ctcccattgt gtctaatgtc acattttggg attcaatcaa
     8881 tcgggcaacc tggagaggag cttgtgcctc ttctatttca tcaggattag actgctgttg
     8941 tatccattct tctacagaat tgaggctctt tagtatggtt gataatgcct tttggctttc
     9001 ggctgggtca tcccaattta aatctaatgc ggcttttaag ctggaactat tgacaaaatc
     9061 cgctcccgct tcattggcaa tttctgccag cccccacccc tgctgactag ctattatgct
     9121 caatgcctta cgcagagcat gacccaagag attataggta tcttcaactt tacctgcacc
     9181 ccataaagga gaggaatcta atgcagctct taagttagcc gaaccaaaac ctcctttgag
     9241 cttggcaatg tctacagtcc ggtcaattaa acgttggtca aagccttttt taattaaggc
     9301 gcttctgaat cttattaaag tggctttact gaatgggggt ttttcgcagt tcagacaatt
     9361 cagagctaat tgccatcgta ggtccatgac tagctcttca atcacttcct cgtcagaaat
     9421 acccatataa gcttggagaa tagtggctaa ggccaattgg gctggtgcga cgggacagtt
     9481 gcccattgta ctgtctttaa aaatggtgtt tagttcttct tgaaactcat catcgaatat
     9541 gaacagacgg ttcaggcgaa gaaaagtaaa aagcttggct tttttgatgc gattaataat
     9601 tacctgttct gaatctgata gctctactgg cgggtgccac aaaggaggac gcatagactt
     9661 tataccgtaa tgagggcttg aatttaatcg ggtcgtcaat ttcagttagg catagtccag
     9721 ttattttgtc aagctcgggt actgaaccga cgccctaggg gaacgcgaac tccccgggca
     9781 ttaaatccca gggtttgtgc cccttgtttc aaatttaata aggtggtgcc gagttgtcca
     9841 gttccggcag cttctctggt ccgtttaatg gaaaattttt tgccataggc agaggaaacc
     9901 gtggctaaac aagccgcccc acaatcttct tcattgtgtt gcaaaattac cgggtatttt
     9961 ttcataaaat ttcaggagat atcaaagaaa aatgactgat ttacaagccc tcggagtcat
    10021 cggattgagg ggagaggatg gggggacgaa gtgcgaggac tgaactcacg gtttctgggg
    10081 tcgccaaccg cagtaatccg taaccgattc cggcgagtcc actcatcaat ccaggggttt
    10141 ccacacccaa aggagtgccg cacagccaac cctcagattg gatactttcg aggatgctgc
    10201 cgcccgtgtg gaggtgagaa tgccactggg gttcccccag ggtgagactg gcttgtaaga
    10261 caaattctaa attgcccaaa tctccttggg cgagggagtg attctgtcca aatccccgat
    10321 cgcaggtgat gtccagggct gtataaattt cctggcgaat ttggggatca tcctgatgct
    10381 ggagggcata caaccgggct aatccaatcc ccggtgcacc gtgagaccag gcgagaggac
    10441 ccagattccc cacccttggg gaatggtcaa attctcgaaa atccggccag ttgcgggcat
    10501 tggggtcaaa gacactgcgt tcgtaggcga tcgccgcgat cgctgccttc tgaaaccgct
    10561 ctagttgcgt cactgccgcc agttccagga gtgcgtaagc aattcctgcc gccccgtgag
    10621 agaatccggt taagggtcgc ttgctgcgga tagctgacgg aatccaaccg atgccggttt
    10681 cctggggtct ggcaccgata atcaggcgat cgccacattg aatcgccaca tccagaatct
    10741 gggaatccgg ggccactgca tataaactta acaaacttaa aatgcagcct gctgaccccg
    10801 aaataatatc ccactcttca tcctgaagga tggcctccgg taaatagtcc agccattccc
    10861 tcgctacgga aatcagttga ggttgattga gctgaattgc caaatggctt aagctataaa
    10921 tcgcactccc gaacccggta aacccgccaa ttgactcccc aggtttcaac tctttttcta
    10981 agcaaacttg ccaataatta agcgccgcaa cggctaagtt ttgatagcga acttcttggg
    11041 taatgttgcc caaataagcc aaaaataagc taattcccgg cagtccatca tagagatgaa
    11101 tatcaacccg gcgaatggct aattcccctt ccctaatcca agtcagtccg atccagtcgg
    11161 ccatctgatt ctgacagagt gctacctgtt ccagtctatc tccaatggcg caagccgctt
    11221 tcaaataggt ctgggaactg ggacgggttt ctggaacccg catcggatac gaaggccatt
    11281 gaatggcgtc tggggaccgg atgacggtgg cgatcgcagc acgaatcaat cccacttgtc
    11341 gttctaagtt cgtttcatcc atcccttgca ggtgaaggcg gacagaatct agggcagatt
    11401 ctggtaaaaa atctgagatg atttccccct gacccgactt taaatctcgg gaatttggct
    11461 gagtggtaaa tcggggaata tccccttgcc ataactcttg aatttcagca ggtattaccc
    11521 gggctaaact cggaaaatta ggcacttcta cccagagttt atcaaatagg cgatcgcggt
    11581 ctaacgcatc ccgcaacaag tccggatgaa atccctcctg caacaataat ccataagtcc
    11641 gagtcgcccg caaaaccacc cggatttcat cctcagcaaa cgtattgaat agcccagact
    11701 cacccaccaa attatcccta tttttgacca aaactcgata aatttctgta aatcccgtaa
    11761 taattgctgc cgtataatct tccaacttta ccgaggcccc gttcagggtg ggacgattca
    11821 aatctggggg taattgaacc gctttacgag agattttcat ttcatcggtt gccactccct
    11881 gccaggtggg aatggcatca ggagtcatgg gactgcctga gttccctaac ccactaatat
    11941 caatccctcc atacccttga ttcccccaca aattcatcgg taaaatcccc acacttaaca
    12001 cagaccaatc cagttctctt tccgccaaac agtcggaatt gaacccctcc aattggctat
    12061 accgagggtg aaataaagat tccaaatcta ctaaaatcgg ctgttctccg acggcgataa
    12121 tattattgct ataaaaatcc gtagcttgga gggcatataa taaggctaaa tatcctccct
    12181 gtctttgata aaatcgctca atttgagcgg cggtatcaca gggttgagca gtcacatatt
    12241 ccacccaacc atactccccg caattgagaa cattcaagat tgggaagggg ggataattgc
    12301 cttgtttatt gagccaattt agtaaatttt gaaaatgaat atcaatgctg agagagcggg
    12361 gtttataaac taatttaaac ccggaactaa actcggcgat cgccaccgaa cgtcccccat
    12421 tatgcgaatc ccccgcattg gaattcagat ggactaatcc gcccggttca gagtcccgac
    12481 taaactgctg gataattctc ggccaatcct gacagaggcg ttccacaaat tcataactga
    12541 cggtaatcca tccctggatt gaattaagga cttgccgggt caaaaccggg tattctgtcc
    12601 acaaggctag agccatttcc ggttgttgca gttgctgaat aaactgagca aatctttcgg
    12661 cactactgtt accagataat tttccttgga tgcgcgctac atttaattcc aagactaaag
    12721 tgcgggtact catccagagc aattctttcg gtaaaggttc atacaaaatt gcggcaatgg
    12781 tttgggaatt gatgcagtca ggggagtgga tggacagcaa ggtttgaagt ttctcctgga
    12841 ggcaactgcg cccccaggca attaacggag aaaatagggt taaaaaccca gagactccgg
    12901 attgagtatc actcagattt ccggtttccg acagcgcaga gaacggataa gttgacagga
    12961 tatcggataa ggttttgatc cagtttggag gttccggaaa ctgatgggct agggtttccc
    13021 ttgattcttc taataattgc tgaaactccg gttccgtgag tccatcgctg gccaaccgtt
    13081 gtgcaaaata aatgtcgtta ttaaacggag tctgcgatcg ccaccgttgc aatcgccgat
    13141 cgcctaacgg ggtactccct gccttagggc gatcgcccga ggcaatccgt tcccgcaaag
    13201 ggatcccgcg ataccactga actcgttggc tgttttcttc cttcatcgtc gatcccctct
    13261 actggattgc ttccctcacg ccgcctctgg gtttcctgaa ccccgactca actgcgatcg
    13321 ggtcctactt tttgccaccc cattctccca taaaattaga atgattttca ttctaatttt
    13381 atgcttatgg gttccagggg tctggagggg agggaagaac acaaggtgag acataatagc
    13441 ggtatcacta ccggattgcc tgtgattttc ccaaactgaa atcggcagct attttacagc
    13501 cgatcgccct gactgggtaa accgattgat agcataagca ataagactat cttgtaggaa
    13561 gggataaaga tgaacccaga taatagccga cccgatcgcg acaaccccat tccaggagaa
    13621 ccattaacac cccctaatcc gggcattccc cgaggcgatc gcgcttatag tccctctgaa
    13681 caatcccgga accctgttga ggacctgcga cgggaacaag aacgtcacat tcaaaacctc
    13741 ggggaactgc ggcaagagga ggcgcgatta agccgacagc ttcaggaatt acgacaacaa
    13801 gaagaacata tccaccgccg aattgaagga attcaattgg aagaagagga acgaagaatt
    13861 gctgaagtta gacgcagatt ggctttaagc aagaccaatc aagtgattta ctatctgatg
    13921 ggagcattgg gagtcttgtt ggttttacgg attctgttgc gactgttagg cgcaaaccca
    13981 gacaaccagt ttgctggatt tatttatgcc ttatcctctc cctttgtcac gccgtttgaa
    14041 actttgttta caactccgac ttttggaaat tctgcttttg aattcaatgc tttgattgcc
    14101 atagctgtct atggattact aacttggttg gtgattcggt tactggaatt aatttggact
    14161 taacctaaat tgatccttaa tgaggtttga gcagacccct aaaataggag agaggcaacc
    14221 ccattgggat tgcctctaca aaatattgcc gttgatgatt gaaccggctt ttattaaggg
    14281 gtgttggaag cgtctaagtc tgccggactg gttaaagtgg caacagggac agttttcccc
    14341 atcgaggctt gcaacataga ggtccgagaa acagaattat tcgccaaagt aaacagggga
    14401 ttagacagaa tcccagcgag ggaagtggca atcaccgtca ggattaaacc cacttggagc
    14461 gatcgcattc cccgtaaatt ccagctaatt tccggataat tcttgactgc ctcggacatt
    14521 tcctgcggtt ccttaaccac catcatcttg acgacgcgga tgtagtagta aatcgaaact
    14581 acactggtta ataaacccag caagactaag ccataaagac ccgcttgcca acctgcccag
    14641 aagagataaa tctttccgaa aaatccagcc aggggaggaa taccccccag agagagcaaa
    14701 caaatactta accccaaggt taataacggg tctttttgat aaagccccgc atattcgcta
    14761 atttgatccg ttcccgttcg cagggtgaag agaatcaaac aggtgaatgc acccaagttc
    14821 atgaacagat aaaccagcag ataaaaaatc atgctcgcat acccagcatc ggtattggca
    14881 attaaaccaa tcatcacaaa acctgcttgt ccgatggagg aataggcaag catccgtttg
    14941 agactggttt gagcgagggc caccacatta cccaggacca tactgaggat ggcgagggcg
    15001 gtaaacacga agtgccactg ttcttcgacg agggggaatg ccgtcgtcag cagacgaatc
    15061 gctagggcaa accctgctgc tttagaaccc accgagagga atgccacaac cggggtggga
    15121 gagccttcat aaacgtcggg ggtccattgg tggaagggaa ccgccgagat tttgaacgaa
    15181 ataccggcaa tcacgaatac cagggaaatc accagaccaa tcgaggggcc tgtgccagaa
    15241 gcggtgatgc ccgaggcgat cgcacttaag cgagtttctc ccccggaaag tccatacaac
    15301 aacgacattc catagagaaa caccgacgaa gaggcagcgc caatcagcag atattttaaa
    15361 gccgcctcat tggaacgggg gtccagcttc atgtaacccg tgagcagata cgatgaaata
    15421 cttagggttt ccaaagacac aaaaatcatc accaactcat ctgccccaga gaggaacatt
    15481 ccccccagag tggcggtgag caaaatcatc agaaactcgc ccattgcggt gccggagttt
    15541 tccacatagc ggatcgacat caaaacggta accaccgcag acagggcgat aatgccgcga
    15601 aagatcacac tcatggagtc cccattgaac ccaccgagga acgaaatcgg gtcactggca
    15661 tcccattgat aaaccagggc caccagggcc gctagtagac cggcgatcgc catgtagggg
    15721 gtcactttca gcgactcccg tcctacgatc aggtcataaa ccaggaccac cagcagggta
    15781 atgatgacaa ttccctctgg caaaattatt ccagcattta actgggcggc aagattagca
    15841 aagttcatag caacttatcg gcagatacaa tacaatcact cagcatcaag ttggtgcagt
    15901 tcgtgcatta gcaattcttt acatcttgca tcttaccttg atatccgccc gaacccctcg
    15961 aatcacctcg actcctctag ttgaaaccca gtgatccccg accccattga ttcatctcaa
    16021 ccaacgggtt gctgttcaga gtaacgccta aaacccattg caactgggga gaaagcgcca
    16081 atccaatccg cgatttcttc acccccttcc ccatttttgc ctccggtttc ctctgcttgt
    16141 gttagggtca atttagggag cttctcccca actctatgga cctcagatgg aaaaaactct
    16201 gatccgagtg ggatgttaag ttacccttga tcacccccat ctatagatat ataaggagat
    16261 cgggaaccct ggcgatccag aaccgaggcg atcgcctcgt tcaagtcctc cgggtagaag
    16321 tcagtctcag cctccagcct caagtcccca acaccgaacc gcccatcccc cgatactgca
    16381 acccaattac gttagggaaa tcggatctaa attagagatt ggcacggatc gaccagcagc
    16441 gatcaactgc aaagacgggg cagctagata cccgctagac tgatacccct ttcccgatcc
    16501 ccccttgaca tctcccccaa aaagctctaa agctgacgtt ctacaaagct gctatcccca
    16561 aaaggtgcca tgtcaaccct cgtcatcgtc gaatctccaa ccaaagcccg cacgattcgg
    16621 aacttcctgc cgaatgacta tcgcgtagag gcatcgatgg gtcacgtgcg cgatctgccc
    16681 tcctctgccg atgaaattcc cgaacaagtc aaaggggaaa aatgggcgca gcttggggtt
    16741 aatgtagaag ccgattttga gcctctctac gtcatcccca aaaccaagca aaaagtcgtc
    16801 aaaaccctca gagatgccct caaacaggcc gatgagctga ttctggcaac ggatgaagac
    16861 cgggaaggag aaagtattag ttggcatctg caagaagtgc tcaaacccaa ggtgcccatt
    16921 aagcgcatgg tgtttcacga aatcacccgg gaggcgattc gtgatgccct caacaattgc
    16981 cgcacgattg attaccaact ggtccatgcc caagaaacca ggcggatttt agaccgcttg
    17041 gtcggttata ccctctcgcc tctgttatgg aaaaaaatcg cctcgggact ctctgccggt
    17101 cgggtgcagt ctgtggcggt gcgtctgttg gtgcaacgag aacggcagcg tcgcgccttc
    17161 cgtcaagggt cctattggga tttaaaagcg cggttagttc aggccaaaac cccgtttgag
    17221 accaaattgg ttaccttggg cgatcgcaaa gtggctaccg gcagcgactt tgatgaatcc
    17281 accggccaaa ttatcgccgg tcgcaacgtc gtcctcctca acgaagaaca agcccgggcc
    17341 ttggttaccc aaatcaccgg caaaccttgg caagttgcca aagttgagga acgtcccacc
    17401 acccgcaaac cctcgccccc ctttaccacc tccaccctcc aacaggaggc caaccgcaaa
    17461 ctgcggttat ccgccaggga tacgatgaaa attgcccaaa gtctctacga aaatgggtac
    17521 atcacctaca tgagaaccga ctcggtgcat ctgtcagaac aggccctcac cgcagcgcgg
    17581 acctgtgtgg cagaaatgta cgggaaagag tatctcagcc ccaaaccccg gcaatatgcc
    17641 accaagagca aaggggccca ggaagctcac gaagccattc gtccggctgg aagcagcttc
    17701 cgcactcccc aacaaactcc cctctcggga cgggaattac aactctatga tttgatttgg
    17761 aaacgcacgg ttgccagcca aatggccgat gcccgtcaaa ccatcgtagc ggtggatttg
    17821 caggtggaaa atgccggatt tcggtccagt ggcaagcgga ttgatttccc gggattttta
    17881 cgcgcctatg tggaagggtc ggatgatccc gatgccgcat tagaggacca agaggtgatt
    17941 ttaccggctt taaaagttgg cgatcgcccg aactgccaaa acatcgaagc agtcggtcat
    18001 gaaacccaac ccccggcccg ctatacggaa gcctccctgg tcaaaaccct agaaagcgaa
    18061 ggcatcggac gcccgagtac ctacgccagc atcatcagta ccattatcga tcgcggctat
    18121 tccatcctta aagggaatgc cttagtgcca acctttaccg cctttgccgt taccgatttg
    18181 ttggaaaaat acttccccga attggtagac cccggcttta ctgcgaaaat ggaacggact
    18241 ctggatgaga tttccaccgg agaagccgct tggttaccct atctccagaa gttttatctc
    18301 ggggaaaatg gcctggaaac ccaagtcaaa caacaggaaa gtgcgatcga ccccaaccaa
    18361 gcccgtagcg tcgaattgga gaacctcgat gccaaagttc gcatcgggcg ctatggaccc
    18421 tatatcgaag ccgacaatgg cgatggcgtc gtcaccgcct ccattcccaa ggacctcacc
    18481 ccctcggacc tagacccgga acaagtccaa ctgattctca agcaaaaaac cgaaggacct
    18541 gaccaactcg gtactgaccc caataccggg ctacccatct atatcctgat tggcaaatat
    18601 ggcccttatg tccaactagg agaagcgacc gaagagaata aaaaaccgaa acgggcttct
    18661 ttcccgaaag gtgtcaccgc agaaaacttg accgtagaac aagcggtggg actgttagcc
    18721 ttgccgcgta ccttgggagt gcatcccgaa aatggtggca aaattcaagc cagtttagga
    18781 cgatttggac cttatgtggt ttgcgatcgg gggaaagaag agggcaaaga atatcggtcc
    18841 ttgaaagccg gagatgatgt cctcagcatc accctccctc gcgctttaga gttactcgcc
    18901 gaaccgaaaa agggacgcag tagcaaaacc agcaaagcca aagaacccct ccgggaactc
    18961 ggcaaacatc ccgcagatga cgaacccgtg aacgtttacg acggacccta cggaccctac
    19021 gtcaaacatg gcaaaaccaa tgcctcggta cccgaaggca caactgtaga agatgtcacc
    19081 ttggcacaag cggttgaact gctggcggca aaagcatcta cctctaagag taagagtaag
    19141 actagcagca aatccaaaac cagtagtacc aagtcaaaaa cggggacaac caagaagaaa
    19201 tctacaactt ccaccgcgaa gaaaaagagt taaactgtga atcaggggtg cgttgccgat
    19261 gagataacgc gcccttttgt ttaatttggg gttaattacc ctagccttgt caaggtcgta
    19321 aatttaatga caaaaatttg ttatttcttg taggcgcaca atgcttgcgc cctttgtaga
    19381 ggcgcttccc aaagcgcctc tacaaataca cattgacagg gctagaggcg attctctaat
    19441 ctcccctata agggcgcaag cattgcgccc ctacaaatac aaggtgacag ggctaggtta
    19501 attccctata aaatatagaa acaccaaaaa tcaatctgac ccttaataaa atgattacca
    19561 cagcacctca aaattatcgc aatttgctag gggaaaagcg cgtttccttg cgaggcttaa
    19621 cttggcaatc ttatcagcag attcttcatg ctttacccca aagtcgttcc gcccgtctga
    19681 cttatgactg cggtatttta gaaattacga tgcctttaga aagtcatgaa tttggcctaa
    19741 gattgattga agtttttatc cgcattctcg tgtttgagat ggggatgaag attaaaacaa
    19801 tggggtctac cacgatggat cgagaagagt tagatcgcgg tgcagaaccc gattgcgcct
    19861 attatattca aaatcaatcc cgagttgcag ggcggaccgt agattttacc accgatcccc
    19921 ccccagattt ggttgtagaa gtcgatataa cccacacaga tattgataaa aatcgtctct
    19981 atgcggcgat ggaagtgccg gaattttggc gctacaatgg ccgggaatgg cggatttatc
    20041 aattggcaga aggcatttat caagaatgcg atcgctctcc tacctttacc tgggttgaaa
    20101 aagagtattt atatgagttt ttagaacaag cccagcagga tgaaatggag gcagaacgag
    20161 catttagaga acgagttcga gcgaatctct cctcccagaa aaagaccgaa gaatgatcca
    20221 caaatcaggg atgagtaaaa cacaaaacct gttacagcca actctcaatc ccttcccaac
    20281 tctgaccttg aataatttgg gttagaataa aaccaaacct aacctacgag ttgctatgac
    20341 ttctaccctc agccaacgca cctatacggt tgatgaatat ttagcccaag aaattgcctc
    20401 ccaggaccgt catgaatatc gtaatggagc acttgttctg atggccggtg gtactcccaa
    20461 tcataatcaa attaccttaa atttggctgg ttccttaaat tttgtgttgc gacgccaacc
    20521 ctatcgggtc tttatcgccg atcaacggct ttggattccg gaccggcgaa tttatactta
    20581 tcctgatgtc atggttgtgg gtcagccgat agaattgcaa gaagggcgca aagataccat
    20641 taccaatccg attgtgattg cggaagtgtt atcccagtct actcgcagtt acgataaaga
    20701 tgaaaaattt gcagcttatc ggagtcttgc cagttttagg gagtatttat tgattgacca
    20761 atacaccgcc catattgaac attacaccaa aactgagggt caggcttggc tgtttcgcga
    20821 gtatgatggt ttggaaacaa cgatttcatt tcaatctttt gatttctccc tatccttggc
    20881 tgatttgtat gataaagtcg attttgcccc ggcagaagtg aaggttgagt ctgatttaga
    20941 actgagttag tttaaggttc tcttttgatg agtattgctg tttttcaagg gtttaggaac
    21001 agttgtttct tgaattcaac cttgctctga ttcggattta ggataggagg gaatggaaat
    21061 tgtaaattct gtgccttggc ctaaagttga attaactgct agggttcctg agtgtttttc
    21121 cacgataatc tgacgggcga tcgccaatcc tagtccggtc cctttaccca ccgctttggt
    21181 ggtaaataaa tactcaaaaa ttttggcttg caacgcttca ctcattccta caccattgtc
    21241 ctgaatccga ataatcacct gttgctggtc agaggagagt tcagttttga taataatttg
    21301 atgattgatg tcagcatagt tacatccttg attagattct tccagagcat cgatcgcatt
    21361 actcaaaaga ttcataaata cctgatttaa ttgtcccgca tagcatacga tgattggcaa
    21421 atcactatag tgcttaatta ctttaatctc tgggcgagtt tcatcggctt tgaggcgatg
    21481 cttgagaagc attaaggtac tatccagtcc cgagttaata ttgcaagcaa cagggcgatc
    21541 gctgtcagca cgggagaagg ttctcaggct attactaatc tcgttaatcc gtttgacgcc
    21601 ttcccgcata gaatcgatta attccggcaa gtcggctcgg atatagtcga gttcgatttc
    21661 ttctatttta ccttgaactt ccgggtctaa atttggatac ttttcgtgaa ttatatttaa
    21721 caaatcaaac aaatcattaa tgtaatccaa agctggatca atattaccac ttaaaaagtt
    21781 aaccgggtta ttgatttcgt gagctattcc agcgactaag tttcccaagg ctgacatctt
    21841 ttcgctttgc acgatttgaa gttgtgcttc tttaagatcc gttaaggttt gttgtgcagt
    21901 ttgatagaga cgggcatttt ctaaggaaat agcagcttga gcgcatatta ggttgaggac
    21961 ttccacgcga tcgctggtaa aagcccctat ggtcagatga ttttctagat ataatacgcc
    22021 caccaactga ccttgattga gaatcgggct acacagcaca cttttaggtt gatgcttttg
    22081 aatataacta tcctctgtaa actgaggatg aattcgagca tctcctaaga taatcggttt
    22141 tccagtccgc ctgacattat ttaccaaagt aatcggaata tctgagctag attctaggga
    22201 aattgagggt aagagttggg gtgattttcc aaactctatc aatccgacaa cttttaaatc
    22261 tatcccttgt ttaagcagta agacacactt attagcgccc gcattgccaa tcataatttc
    22321 taggagggtc attaaaagtt tgtctaattc aatctcgcta gaaatcactt gagaggcttt
    22381 aagcagggtt tttaaatcta aggcgtcaga gatgctgcta gaggtgtgag ccgaagtgat
    22441 ggttcctcgg gcaatggttt gttgcaataa gtcgttggta cgagggggtt ccaagatagg
    22501 taacagaagt tgaggataac gttgttctaa atctgcaacc ttggctttag cgccccatcg
    22561 tgaataacaa tagtacgctt cctgcatata gacggtggca attttttctt tgtcccattc
    22621 taagtaaaat ttagcggcta gttcattggc gagtgcttct tcttggatat attcgttttg
    22681 tttggctcct ttaatcgcca agtcatagaa ttctagggct gctgctggtt gactgagaac
    22741 gcgatgtttt tcggcttcaa ctaaataaaa tttatggagt tgattcatgg gtgcagcatc
    22801 agcccatcgt ttgctttttt cctgattaac agtcacccgt tgtaaaatgc tttgttgttc
    22861 tgccggagaa acttgagaat agttcgccag atgagttaga gaatcataag tatggaaaac
    22921 aggaattagg gacattccgg tagccccacc taagtaactt tcaagagccc tagcagatgc
    22981 agtcgcctct ttgatttgcc caaacagata acacagcacc aacttgctca cataaagata
    23041 gcaaggagct gtttgattcc ccacttccag aaaaatcggc agatcctcgg cttcactaaa
    23101 aatatccccc ttaaattgcc atgcttctgt tgaacttcct aataaattga caatggcttg
    23161 ttgaaatata gctccttgtt tggccatcgt tttttgtttt tgttgagcaa attgagcaca
    23221 aaaagcagca ccttctcgac tcaaat
//
