LOCUS       NC_019693              20927 bp    DNA     circular CON 07-JUN-2024
DEFINITION  Oscillatoria acuminata PCC 6304, complete sequence.
ACCESSION   NC_019693
VERSION     NC_019693.1
KEYWORDS    GSC:MIGS:2.1; RefSeq.
SOURCE      Oscillatoria acuminata PCC 6304
  ORGANISM  Oscillatoria acuminata PCC 6304
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Oscillatoriaceae; Oscillatoria.
REFERENCE   1  (bases 1 to 7689443)
  AUTHORS   Gugger,M., Coursin,T., Rippka,R., Tandeau De Marsac,N.,
            Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C., Tapia,R.,
            Davenport,K., Daligault,H., Erkkila,T., Gu,W., Munk,A.C.C.,
            Teshima,H., Xu,Y., Chain,P., Chen,A., Krypides,N., Mavromatis,K.,
            Markowitz,V., Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G.,
            Pagani,I., Pati,A., Goodwin,L., Peters,L., Pitluck,S., Woyke,T. and
            Kerfeld,C.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Finished chromosome of genome of Oscillatoria acuminata PCC 6304
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7689443)
  AUTHORS   Gugger,M., Coursin,T., Rippka,R., Tandeau De Marsac,N.,
            Huntemann,M., Wei,C.-L., Han,J., Detter,J.C., Han,C., Tapia,R.,
            Davenport,K., Daligault,H., Erkkila,T., Gu,W., Munk,A.C.C.,
            Teshima,H., Xu,Y., Chain,P., Chen,A., Krypides,N., Mavromatis,K.,
            Markowitz,V., Szeto,E., Ivanova,N., Mikhailova,N., Ovchinnikova,G.,
            Pagani,I., Pati,A., Goodwin,L., Peters,L., Pitluck,S., Woyke,T. and
            Kerfeld,C.
  CONSRTM   US DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JUN-2012) US DOE Joint Genome Institute, 2800 Mitchell
            Drive B310, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Oscillatoria acuminata PCC 6304
            collection_date                   :: Missing
            lat_lon                           :: Missing
            depth                             :: Missing
            alt_elev                          :: Missing
            country                           :: USA
            environment                       :: Missing
            num_replicons                     :: 3
            ref_biomaterial                   :: PCC 6304
            biotic_relationship               :: Free living
            trophic_level                     :: Missing
            rel_to_oxygen                     :: Missing
            isol_growth_condt                 :: Missing
            sequencing_meth                   :: WGS
            assembly :: Newbler v. 2.3 (pre-release), VELVET v. 1.0.13, Parallel
            phrap v. 4.24 SPS
            finishing_strategy                :: Finished
            GOLD Stamp ID                     :: Gi04162
            Funding Program                   :: DOE-GEBA 2009
            Gene Calling Method               :: GenePrimp, Prodigal 1.4
            Isolation Site                    :: soil
            Isolation Comments                :: isolated by MB Allen
            Temperature Range                 :: Mesophile
            Gram Staining                     :: Gram-
            Diseases                          :: None
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Finished
            Current Finishing Status          :: Finished
            Assembly Method :: Newbler v. 2.3 (pre-release), VELVET v. 1.0.13,
            Parallel phrap v. 4.24 SPS
            Genome Coverage                   :: 30x
            Sequencing Technology             :: 454/Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000317105.1-RS_2024_06_07
            Annotation Date                   :: 06/07/2024 01:39:59
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,147
            CDSs (total)                      :: 6,067
            Genes (coding)                    :: 5,990
            CDSs (with protein)               :: 5,990
            Genes (RNA)                       :: 80
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 77
            CDSs (without protein)            :: 77
            Pseudo Genes (ambiguous residues) :: 0 of 77
            Pseudo Genes (frameshifted)       :: 34 of 77
            Pseudo Genes (incomplete)         :: 37 of 77
            Pseudo Genes (internal stop)      :: 20 of 77
            Pseudo Genes (multiple problems)  :: 12 of 77
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:52:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1491065
            Orig. end                         :: 1511992
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003607.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 4086915
            Source DNA and Organism available from Cheryl A. Kerfeld
            (CKerfeld@lbl.gov)
            Contacts: Cheryl A. Kerfeld (CKerfeld@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20927
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20927
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20927
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10927](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10927
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(173..301)
                     /locus_tag="OSCIL6304_RS36305"
     CDS             complement(173..301)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OSCIL6304_RS36305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_284690282.1"
                     /transl_table=11
                     /translation="MSPLAVAIASCKKFQRANQPKISLIVNPSSKTREVETTAWAK"
     gene            776..1039
                     /locus_tag="OSCIL6304_RS06020"
                     /old_locus_tag="Oscil6304_1221"
     CDS             776..1039
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF036806.4"
                     /locus_tag="OSCIL6304_RS06020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1221"
                     /product="hypothetical protein"
                     /protein_id="WP_015147584.1"
                     /transl_table=11
                     /translation="MSSFGYFRLKPRPEHIRAVLEALKQQDAIAPQELAKLSGLTLTQV
                     KCALSELELRAKIKILRRDSTPRVRVTLVKRSESNSPDLKTC"
     misc_feature    1118..1127
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            1814..2476
                     /locus_tag="OSCIL6304_RS06025"
                     /old_locus_tag="Oscil6304_1222"
     CDS             1814..2476
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016202.4"
                     /locus_tag="OSCIL6304_RS06025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1222"
                     /product="VanW family protein"
                     /protein_id="WP_232251441.1"
                     /transl_table=11
                     /translation="MKLSMLNTEVLNLFKTQISIRQAIPNNSYLENKKHNLATAIACIE
                     NIPIQPGQIFSFWHLVGEPSQQKGYLESRAIVNNQLKYDFGGGLCQLPGLLYVLILKAG
                     LNALERHPHSKDIYTEETRFAPLGSDATVVYGYKDFRFQNTLSVPLCFRFTLLDEAIIA
                     ELCSTQPLEEFSVDFKVEQLPGGIKQVETLRYSELTDSLEKINITIYPPLDPDAASL"
     gene            2602..5298
                     /locus_tag="OSCIL6304_RS06030"
                     /old_locus_tag="Oscil6304_1223"
     CDS             2602..5298
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012307910.1"
                     /locus_tag="OSCIL6304_RS06030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1223"
                     /product="DNA methyltransferase"
                     /protein_id="WP_015147586.1"
                     /transl_table=11
                     /translation="MSNSAEKLQTFITYCQQHIKGDEKGEAQVFLDRFFRAFGHEGALE
                     AGASYEERVKKGSKTGKTGFADLVWKPRVLIEMKKRGEKLQKHYSQAFDYWTRLVPDRP
                     RYVILCNFDEFWIFDFDIQLDTPIDIISLQQLPERAGAFTFMELENRTPVFNNNQVEVT
                     ERAARRLGELFIELKKTGNRRGFTESVAQRFILQCVLAMFAEDRGLLPRDLFISSVQNC
                     LNGASSYDILGGLFREMNTPGITGAGRYKGVDYFNGGLFAVIHPIELTREELQFLDVSA
                     REDWSQVRPAIFGNIFEGSVNETERHTYGIHYTSEADIMKIVRPTISRYWEDRIEAATT
                     IPELNGLQMELQSYRVLDPACGSGNFLYIAYQELKRIEQLLLEKIASRRKSPREQLEIG
                     FVTPLQFYGMDTNPFAVELARVTLAIARKVAIDKFGLTEDPLPLDTLDKNIVCQDALFN
                     QWPKVNAIIGNPPFLGGKHLRINLGDDYIDRVFARFPDVKDSVDFCAYWFRLAHDRLND
                     TGRAGLVGTNSVSQGKSRVATLDYITQNGGYIHEAVSSQPWSGEANVHVSLINWMKEEP
                     HQYYLDNSLVFFINPSLQSTINVSQAVRLNVNKNRCFQGVIPVGKGFVVTEKEVKTWIK
                     SDPQNQKVLKLFSMGLNLAKNPQGKPDRWIVDFNDMTIEDASDYILPFEHIQATVKPER
                     DKNRDAKSRTYWWRFLRHRSEMRNEIASLSHYFTVPRVSKWAIFIPAPLTWLPGDKSVV
                     VASDDFYVFGILTSTIHRTWMHAQKSTLKSDIAYTHNTCFETFPFPQTPDPKLVKSIRD
                     SAQKLHDYRTQQMESKQWGITQLYNKFFHQPTSQLFKLHAQLDQLVMQVYRFNETDNIL
                     EKLLKLNVELAKKEQRGEFVLGPQAPD"
     misc_feature    complement(5327..5345)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.13"
                     /tool="antismash"
     gene            5347..6651
                     /locus_tag="OSCIL6304_RS06035"
                     /old_locus_tag="Oscil6304_1224"
     CDS             5347..6651
                     /EC_number="2.1.1.37"
                     /GO_function="GO:0003886 - DNA
                     (cytosine-5-)-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006304 - DNA modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007355187.1"
                     /locus_tag="OSCIL6304_RS06035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1224"
                     /product="DNA cytosine methyltransferase"
                     /protein_id="WP_015147587.1"
                     /transl_table=11
                     /translation="MNPQTRPIAVDLFAGAGGMTLGFEQAGFDVLAAVEIDPIHCATHE
                     YNFPQWKVLCRSVVEATGDLIRTQSQIGSREIDVVCGGPPCQGFSLMGKRALDDPRNSL
                     VFHFIRIVTELQPKYFVMENVRGLTIGPHKQLLDEVIDKFHDSGYQVLTPYQVLNSAHY
                     GVPQNRERLFLIGCREGLSLPDYPTPITNPPGCKKLRQLSDLPATPTVWEAIQDLPRVE
                     DYSELLDRDWLVYTYHLASAYGVQMQGLSESSHNYAYPRECDRSILTGNHRTQHTQPAI
                     DRFKETLPGKSEPVSRFHKLDPKGLCNTLRAGTPSNRGAYTSPRPIHPFEPRCITVREA
                     ARLHSYPDWFRFHVTKWHGFRQIGNSVPPLLAKAVAAEIIQVLGIAPISPSVPKQLENP
                     ELLKLPMSAAAAQYHVDPHTIEPRSRRASTPKTSV"
     gene            complement(7032..7394)
                     /locus_tag="OSCIL6304_RS06040"
                     /old_locus_tag="Oscil6304_1225"
     CDS             complement(7032..7394)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017719349.1"
                     /locus_tag="OSCIL6304_RS06040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1225"
                     /product="response regulator"
                     /protein_id="WP_015147588.1"
                     /transl_table=11
                     /translation="MSIILIVDDSGTVREMVSDILKKSGLEVIEASDGVEAKEQIQAKP
                     PDLVVTDIVMPRMNGYELCRWLKNDPKAQNIPVIMCTSKSQEFDRYWGMKQGADAYITK
                     PFRPAELIQTIKQLLR"
     misc_feature    complement(7507..7524)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 18.36"
                     /tool="antismash"
     misc_feature    complement(7756..7771)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.72"
                     /tool="antismash"
     gene            7991..8155
                     /locus_tag="OSCIL6304_RS33855"
     CDS             7991..8155
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OSCIL6304_RS33855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_156823748.1"
                     /transl_table=11
                     /translation="MPGPLGFYGISLPAYDPTQPNRSPIISLNLGPSTQGRSPFQHFQP
                     SGIAMGCNP"
     gene            8517..9899
                     /gene="pds"
                     /locus_tag="OSCIL6304_RS06045"
                     /old_locus_tag="Oscil6304_1226"
     CDS             8517..9899
                     /EC_number="1.3.5.5"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pds"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015179275.1"
                     /locus_tag="OSCIL6304_RS06045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1226"
                     /product="15-cis-phytoene desaturase"
                     /protein_id="WP_015147589.1"
                     /transl_table=11
                     /translation="MRVAIAGAGLAGLSCAKYLTDMGHTPIVLERRDVLGGKVAAWKDA
                     DGDWYETGLHIFFGAYPNMLQLFGELGIEDRLQWKEHSMIFNQPEAPGTYSRFDFPDLP
                     APLNGVMAILGNNDMLTWPEKIRFGIGLIPAMVQGQKYVEEMDKYSFSEWLKRKNIPPR
                     VEKEVFIAMSKALNFINPDEISATILLTALNRFLQEKNGSKMAFLDGSPTERLCQPIVD
                     YITDRGGEVRLNAPIKEFLLNEEGAVRGFEVRGIEGKPEEILTADIYVSAMPVDPLKVM
                     LPQSWWQMEYFQQLKELEGVPVINVHLWFDCKLTDIDHLLFSRSPLLSVYADMSNTCRE
                     YANPERSMLELVLAPAKDWISKTDEEIVTATMKELSNLFPDHFCGDKPAKLIKYHVVKT
                     PRSVYKATPGRQNYRPSQITPIPNFYLTGDYTMQRYLASMEGAVLSGKLTAQAIASRQS
                     QN"
     gene            10001..10927
                     /gene="crtB"
                     /locus_tag="OSCIL6304_RS06050"
                     /old_locus_tag="Oscil6304_1227"
     CDS             10001..10927
                     /EC_number="2.5.1.32"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006625401.1"
                     /locus_tag="OSCIL6304_RS06050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1227"
                     /product="15-cis-phytoene synthase CrtB"
                     /protein_id="WP_015147590.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.3e-102,
                     bitscore: 339.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.3e-84,
                     bitscore: 281.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQLSEQPRMKTLASLDDAYELCRQITAKYARTFYLGTLLMPEAK
                     RRAIWAIYAWCRRTDELVDGPGARFTTPETLDLWEGYLESIFAGTPIEDTDVAMVDTVE
                     RFSLDIQPFRDMISGQRMDLYRSRYQTFEDLELYCYRVAGTVGLMSLPVMGIAPVVRSS
                     PWESSEPVDPSAEAVALGIANQLTNILRDVGEDARRGRIYLPLEELALFDYTEEDLLNG
                     VVDERWQQLMRFQIQRARKFYVKAEKGILALNPDARWPVWSATMLYSQILEAIERNEYD
                     VFSQRAVVPRYRKMISLPLAWLRAQVL"
     gene            complement(10908..11054)
                     /locus_tag="OSCIL6304_RS33860"
     CDS             complement(10908..11054)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OSCIL6304_RS33860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_156823749.1"
                     /transl_table=11
                     /translation="MSIQKMEVCQLRPNFHVLRSVDGGVAIASGGDRQKSLSKPGFLTE
                     LAP"
     misc_feature    complement(11281..11299)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.56"
                     /tool="antismash"
     gene            11407..12465
                     /locus_tag="OSCIL6304_RS06055"
                     /old_locus_tag="Oscil6304_1228"
     CDS             11407..12465
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017719352.1"
                     /locus_tag="OSCIL6304_RS06055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1228"
                     /product="EAL domain-containing protein"
                     /protein_id="WP_015147591.1"
                     /transl_table=11
                     /translation="MTLLSDLPKLLIQPNDPDTGTYLANLGFQPVPAVPLLLYRIVTRS
                     QLKEIFWQLSNQLGEMAQNASRFVVTQISLDSTHLLLEFLKAQPLISVTNSIKYAWFLR
                     LLLQQGLFFKYQPIFCLKSGQITAYECLARALGDSGQCYSGGMLIEAAIATDLSQEFDE
                     LARTTCIESIAELNSDRQFFVNLLPNAIIQNPDSIEQNLQQILDLGFRPEQIIFELTEV
                     EVLAQSEKLPQLIERMRAWGFGIAVDDLCGCVSVDHYAMELRPDIVKLDRRLIQGCSQF
                     TLKQTLIKSVLESAHSEGIIVLAEGLETIPDIQFCQELGVDLGQGFGLARPEAHLQQQP
                     FEPWDLMMSKAS"
     gene            12568..12708
                     /locus_tag="OSCIL6304_RS35715"
     CDS             12568..12708
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="OSCIL6304_RS35715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_156823751.1"
                     /transl_table=11
                     /translation="MDSPGGDRLKECPGLNSTNPNKEPRSQKMRSRKYSEEKQSIGFFP
                     L"
     gene            complement(12750..13295)
                     /locus_tag="OSCIL6304_RS06060"
                     /old_locus_tag="Oscil6304_1229"
     CDS             complement(12750..13295)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007357663.1"
                     /locus_tag="OSCIL6304_RS06060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1229"
                     /product="RNA-binding protein"
                     /protein_id="WP_015147592.1"
                     /transl_table=11
                     /translation="MSIRLYIGNLPKEVDRKELQDVFAEAGDSVTTKVITDRKTGKCRG
                     FGFVTVKNDEQADEFIEKFNGYMFQDTPLKIEKALPRKKGKGDEEQEGAPPSQTDEATA
                     TSTPTPTPTPAASKVAKPTTGGGGGGARGNNKSKRSTGSSSSSGSGSPDSDSVQPDPRW
                     AGELEKLKQMLAAQASNS"
     misc_feature    complement(13288..13302)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
     gene            complement(14639..17245)
                     /locus_tag="OSCIL6304_RS36310"
                     /old_locus_tag="Oscil6304_1230"
     CDS             complement(14639..17245)
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013594.4"
                     /locus_tag="OSCIL6304_RS36310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1230"
                     /product="M48 family metalloprotease"
                     /protein_id="WP_044194607.1"
                     /transl_table=11
                     /translation="MAMEHSDLQTGLAALKKKDYKMAIAILEKVCEQELHQPTVDRATM
                     GLVMAYKGNRTLSKAVALCQTLTESDSPKVKDWAVRTLAQFNQPSPQGRSAPSSPEPQP
                     QTPKTVNRPGSPPSPLRGNPTGFVPLDPSSSGPAQPSPLKNPNSQGIISPLSLGNPTGF
                     VPLEPAQTKPVSRSPVNPPPMPPRPPGGATPRPGVSPLTPASLPPGPPMPPRPPVPRQD
                     SPQVLPLEADPEEIDYLTPSTKKADSPSAKASEERQPDATPLKVTLPTPQPRQWRQAGR
                     AQNWRKLKPVKPTYLGFAQMGSAIALFWLLRIFMNWGMATTNDLFYRLPLLWPIQSFYR
                     DQTWTLLGILILLLVASPWLLDLLLRFAYGMEKLPPPKLGNYSPEARKLLSRFSVERKQ
                     PALSLGVIPTDAPIAMTYGFAPRFARIVVSQGLLEQLEEDEIAAIYAGELGHLENWDFP
                     LMSLAVLLCQVPYLVYWQVSRDGDKWLDSQEWSGKVMLGTAGVISAVAYGLYWVLRWPV
                     LFLSRLRFYYSDRASASLTGNPNALTRALLKMAIGIAQDVEKQGHTSFVLEGFDLLSPV
                     GYVQGMTLGSCSGFESWENLLQWDRHNGYKKWLMVPQSHPPLGDRLTLLDLYARFWKLD
                     AELDFARDGTVAPAKSSPAMLKRLLLQGAPYFGLPLGLLAGLMLWVFGAVAVNLGFVAL
                     DWVWGDRSILQGSVLIGVSLGIFLRINSFFPDITSKNIRTNPPLPELLTDPNAIPVDSL
                     PIGLEGQLLGRRGLSNWLAQDLILQSPTGLVKLHAASNLGVFGYLWLLSKRPNDVVGQG
                     ISAVGWFRRGATPWIDLDRFTTAEGKTHSSGHPIWSTILAAVAALVGVYWMSKGGV"
     gene            17657..18001
                     /locus_tag="OSCIL6304_RS06075"
                     /old_locus_tag="Oscil6304_1231"
     CDS             17657..18001
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015177374.1"
                     /locus_tag="OSCIL6304_RS06075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1231"
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_015147594.1"
                     /transl_table=11
                     /translation="MYDADKRKLLSLLSHAAIFLSTTLVSIGIPLAILFVSDDPVVKDN
                     AKESINFHLNVWAWGSVIFALSFLTFGLLGFILAPAGFILHWGLTGFALLKVFGNPDQP
                     FQYPFIFRVL"
     gene            18041..18376
                     /locus_tag="OSCIL6304_RS06080"
                     /old_locus_tag="Oscil6304_1232"
     CDS             18041..18376
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007353255.1"
                     /locus_tag="OSCIL6304_RS06080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1232"
                     /product="DUF4870 domain-containing protein"
                     /protein_id="WP_015147595.1"
                     /transl_table=11
                     /translation="MYDSDKRKLLSVLSHGAIFLSATVLSVGLPIAILFLSEDPVVKGN
                     ARESINFHLNIYLYGLIFGLLAVVLIGFPLLLILLAASWILPIVAIVKVLSDPTLIYRY
                     PFIFRLV"
     gene            complement(18503..20641)
                     /locus_tag="OSCIL6304_RS06085"
                     /old_locus_tag="Oscil6304_1233"
     CDS             complement(18503..20641)
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011613777.1"
                     /locus_tag="OSCIL6304_RS06085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Oscil6304_1233"
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_015147596.1"
                     /sec_met_domain="Pkinase (E-value: 4e-31, bitscore: 106.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYCLNPKCPHPNDPANANHVKCVHCGCDVLLQRRYRIIKPLGGG
                     GFGKTFEVDDQGVIKVIKVLLQNHEKAVELFQQEADVLKRINHPGIPKVEADAYFAITP
                     PGETEPIHCLVMEKISGLNLRDWMKKRGNRPVTQNQALDWLKQMVEILDRVHQQNFFHR
                     DIKPLNIMIRLNGQVVLIDFGAAREVTNTYFAKVGQGQNITGIVSPGYTPPEQANGKAV
                     PQSDFYALGRTLVFLLTAKPPTAFSENPRTGKLVWRNSAPQISKSFGDVIDYLMAPFPG
                     KRPQSAQAILQCLAEIDLTPPNGEVGEANTGIGTSGTRGNYNTGSHSNTKSPATESRKL
                     RSQYQPVYPAKSKNSGKSQFLKRGSKKPWISAIAILLVFLATSQVYGYWRYGLFPANPV
                     GLLVNLPSSLFLRRSIREVGQVQSIAMSQLPGAASQSEGGTFASGSFGTIRIWNLNSGT
                     LLHTIAAHKDWVRTLAVSPNGQTLASGSADKTIRLWNMNNGSRMLTIAGPGAHWGPVNT
                     LAFTPDGQRLASGSDDNTIKIWDIRSGTRLRTIQVGSGVNAIAFTPDGRRIISAANDNT
                     VKIWDLATGARLLTLRGHVHPVISLAISPDGNTLVSGSRDNTIAVWNLSTGERRYQLIG
                     DSSWVRSVAIGPDGNILASSGGTIEIWDLVTGTLRHQLTGHSSYVSGIAMTPDGKTLLS
                     GSPDETIKIWRLPSGSQP"
ORIGIN
        1 ggattgagca ctgcttgccg acgggccatt tgccccacca gcagttcccc ttctttgcta
       61 aaaccgacca cggagggagt ggtccgcgtt ccttctgcat tggcaatcac caccggcttg
      121 cctccctcca ttactgcgac cactgagttt gttgtcccca ggtcaatgcc gactactttg
      181 cccatgctgt tgtctccacc tctcgtgttt tactgcttgg attaacaatt aaactgattt
      241 tgggttggtt ggctcgttgg aactttttac aagaagcgat cgccacagcc agtggcgaca
      301 taacagttaa ccctaagttg caatactcag gatattgctt tctgacttta ttctatcttg
      361 cggcagcact gtaggggttt tggcctcagt cagcgcaact cttctgctgg gtggctggga
      421 aaaccccaag ccttcccctt ctccaagcca atcctaggac tgggtacagt tttagactca
      481 atccccagaa tatcggcttt ttctcgcttg agggagttga ctttttctct tcagtcggtt
      541 ttcgggggct aaactagagg ttgaggagtg ttgccgatcg cctcggtgga gggggttggc
      601 aggcaagtag aaagattgat ggtgtgaggg gcgagactga ccgcttcccg gtttctttcc
      661 tggatgccgt acaaagggta cggtttgtga cccgtttggg gttcattcag gacagatagc
      721 tggaggaagg tcagtcacga atcgacgtta acgcattatt cccaggagtt ggaaaatgtc
      781 gtcgtttgga tattttcgcc taaaaccccg gcccgaacat attcgggctg tacttgaagc
      841 gttgaagcaa caagatgcga tcgccccaca agagttggct aaattgtctg gattgacgtt
      901 aactcaagtc aaatgtgccc tgagtgaatt agaactcagg gcaaaaatca aaattctccg
      961 tcgcgattct accccccggg tccgcgttac cttagtgaag cgatcggaat ctaacagtcc
     1021 ggacctcaaa acttgttagt ccatttcgca attgtcggag tctggattga gtcttgaaaa
     1081 gtttagaccc ctgacctatt cagtagcata tcgcacagaa ggcggcgtcg ggatttccct
     1141 aatctcggcg tcgcctcttt tttatccggc ttcacaaggg ctgcgatcgc ttgcagccct
     1201 tgtgagcaaa atacgaccac ttctgggagt ggctatctaa caatttttcc ttttatagat
     1261 aaaaactgcc cattcatttc agggaatata tggaggcgat cgcctcaccc tgagttataa
     1321 tccaaacaac gcatttctac ccgtccatca aaccagtcca tcgaattttt cccgaaattt
     1381 ctctgtcact cggttagcta tatctccagc actttttcaa ggtctgattt ttttggggtc
     1441 gcgatagagg caggataaga cacagatagg tccaaaaacc cgtttttggc ccagagagag
     1501 tgttaaattg cagagggtat aaaaccccgg cttctagctt ttacggtaac tgcatcttag
     1561 gggtaacttt cacccatctc aatatgtagt ctaattttct gactacaaat tatttgttca
     1621 agggaatctg ttccggaatt ttttactatt ctgtaaaacc atgaaaaccc cacgattcaa
     1681 atcattttcc agatttaaac tgaccccttt tttcaacaat ttcaaacaaa atatcccccc
     1741 ttctttcaag cgaaaaggga aacttactca aagatatacc tctgattttt tcacaggtaa
     1801 attaggtaaa ttcgtgaagt tatcaatgct caatacagaa gtattaaatt tatttaaaac
     1861 tcaaattagt atccgtcaag ctattccaaa caatagctat ttagaaaata aaaaacataa
     1921 tttagccaca gcgatcgcct gcattgaaaa tatccccatc caaccgggtc aaattttttc
     1981 attttggcat ttagtcggag aacccagcca acaaaaggga tacctagaaa gtcgggcgat
     2041 cgtcaacaat caacttaaat atgattttgg cggcggttta tgtcagctac ccggactcct
     2101 atatgtttta atcctcaaag ctggtttaaa tgccctagaa cgccatcctc attccaaaga
     2161 tatctacacc gaagaaaccc gctttgcccc attgggttcc gatgctacag tggtttatgg
     2221 atacaaagat tttcgatttc aaaatacctt atccgttccc ctctgtttcc gcttcaccct
     2281 cctggatgaa gccattattg ctgaactctg ttccactcaa cccctggaag aatttagcgt
     2341 agactttaaa gtagaacaat taccgggggg aattaagcaa gtggaaaccc tccgctattc
     2401 tgaactcacc gactccctag aaaaaatcaa tataacaatt tatcccccct tggaccccga
     2461 tgctgcttcc ttgtagggtg ttcgtcgtat ccaatccgaa aggcgatcgc tttcccacac
     2521 cgggtatttt ggtccaattt gtgggatact ctataacaga gtagcctgaa accctatctg
     2581 acgtctaccc aggtttaaac catgtcaaat tctgccgaaa aacttcagac ctttatcacc
     2641 tactgtcagc aacatatcaa aggcgacgag aaaggagagg cacaagtctt tttagaccgt
     2701 ttctttcggg catttggtca tgaaggggca ttagaagccg gtgccagtta tgaggaacga
     2761 gttaaaaaag gtagcaaaac tggcaaaact gggttcgccg atttggtatg gaaacctcgg
     2821 gttttgattg agatgaaaaa acgcggggaa aaacttcaaa aacattattc ccaagcgttt
     2881 gattattgga cccgcttagt tcccgatcgc ccgcgctatg tcatcctctg taactttgat
     2941 gagttttgga tttttgattt tgatatccaa cttgatactc ccatcgatat catcagttta
     3001 caacaattac ccgaacgcgc cggggcgttc accttcatgg agttggaaaa ccgaacgccg
     3061 gtttttaata acaatcaagt tgaagtcact gaacgcgccg cccgacgctt aggagagtta
     3121 tttatagaac tcaaaaaaac tggaaaccgt cggggattca ctgaatcagt cgcgcaacga
     3181 tttattctgc aatgtgtgtt agccatgttt gcagaagaca gaggactctt accccgggat
     3241 ttatttattt cttcggtgca gaactgcttg aatggggcaa gttcttacga cattctcggc
     3301 ggcttattcc gagaaatgaa tacaccgggc atcacaggtg caggacgata taaaggggta
     3361 gattatttta atggcggctt gtttgctgtc attcatccga ttgaattaac tcgggaagag
     3421 ttacaatttc tggatgtttc agcgagggaa gattggagtc aagttagacc cgctattttt
     3481 gggaatatat ttgaggggtc tgtgaatgaa accgaacgtc atacctacgg cattcactac
     3541 acctcagaag cagatatcat gaaaattgtc cgcccgacca ttagccggta ttgggaggac
     3601 cgaatcgaag cggctaccac cattcccgaa ctgaatggct tacaaatgga attgcaaagc
     3661 tatcgcgttc ttgacccggc ttgtggttcg ggtaattttc tctatattgc ttatcaagaa
     3721 ttgaagcgca tcgaacagct attattggaa aaaatagcca gccgtcgcaa gtctcctcgg
     3781 gaacagttag aaattggctt tgtcacgcca ttacagtttt atggcatgga taccaatcct
     3841 ttcgcggtgg agttggcaag agtcactctg gcgatcgccc gcaaggtggc gatcgataag
     3901 tttggattga ccgaagaccc tctccccctg gatactttag ataaaaatat cgtctgccaa
     3961 gatgctttgt ttaaccaatg gccgaaagtt aatgctatta ttggtaatcc acccttttta
     4021 ggcggaaaac atttaagaat caacctgggt gatgactata ttgatagggt ttttgctcgc
     4081 tttccagatg ttaaagattc ggttgatttc tgtgcatact ggttccggtt agctcatgat
     4141 cgcctcaacg atacaggtcg ggcgggatta gtcggcacta actcagtgag tcagggaaaa
     4201 agccgggtgg caacgttaga ctatattacc caaaatgggg gttacattca cgaagctgtt
     4261 tcctctcaac cctggtccgg tgaggcgaat gttcatgtta gtctcattaa ctggatgaag
     4321 gaagaacccc atcaatatta tttagataat agtctcgttt tttttatcaa tccttcccta
     4381 caatctacca tcaatgtatc tcaagcggtc agattaaatg ttaataaaaa caggtgcttt
     4441 caaggagtaa ttcctgtggg caaaggtttt gtggtgactg aaaaagaagt caaaacttgg
     4501 atcaaatctg acccccagaa tcaaaaagtt ctcaaactgt tctcaatggg tttaaatctg
     4561 gctaagaatc cacaaggtaa accagaccgt tggattgttg attttaatga tatgacgatt
     4621 gaagatgcca gcgattatat tttacctttt gaacatattc aagcaacagt taagccagaa
     4681 cgagataaga atagagatgc caaatcgaga acgtactggt ggagattcct acgccatcgc
     4741 tctgaaatga gaaatgaaat cgcctctctc tcccattatt tcacggttcc ccgagtatca
     4801 aaatgggcga tattcatccc tgcaccttta acttggctac ctggcgataa atctgtagtg
     4861 gttgcctcgg atgattttta tgtgtttgga attttaacct caactatcca ccgaacttgg
     4921 atgcacgcgc aaaaatccac tctaaaatct gatatcgctt acactcataa cacctgcttt
     4981 gaaaccttcc cttttcccca aacccctgat cccaaactgg ttaaatctat tcgcgacagt
     5041 gcacaaaaac tccatgacta tcgcactcaa caaatggaat ctaaacagtg gggaatcacg
     5101 caactgtata ataaattctt tcaccaacct accagccaac tgtttaaact ccacgcacaa
     5161 ctggatcaac tggtgatgca agtctatcgc tttaatgaaa ccgacaatat tttggagaag
     5221 ttgctgaaac tcaatgtaga actggcaaaa aaagaacaac gcggtgagtt cgttttagga
     5281 ccccaagcac cggattaaat aaaacagaat aatggtaaac tagagatctg atcgccattc
     5341 gcatttatga acccccaaac tagacccatt gctgtagatt tatttgccgg tgcagggggg
     5401 atgaccctgg gttttgaaca ggcgggtttt gacgtgctcg cagcagtgga aattgacccg
     5461 atccattgtg ccacccatga atataatttt ccccaatgga aagttttgtg cagaagtgtg
     5521 gtagaggcaa ccggggacct gattagaact cagtcgcaaa tcggcagccg cgagattgat
     5581 gtggtttgcg gaggtccccc ctgtcaaggc ttttccctga tgggtaaacg cgctttagat
     5641 gacccgcgca attccctggt atttcacttc atccgcattg tgacggaact tcaaccgaaa
     5701 tatttcgtaa tggaaaatgt tcgcggatta accatcggtc cacataaaca gcttttagac
     5761 gaagttatcg ataaatttca tgactctggt tatcaggttc tgactcccta tcaagttttg
     5821 aattcagcac attatggtgt tccccaaaat cgagaacgtc tctttttaat cggatgtcgc
     5881 gagggattat ctttacctga ctatcccacc cccattacta atcctccggg atgcaagaag
     5941 ttacgccagt tatcggatct gccggcaacg ccaacggttt gggaagcgat tcaagatttg
     6001 ccgagggtag aagactattc tgaattgctc gatcgcgatt ggcttgttta tacctaccac
     6061 ctcgcaagtg cttatggagt tcagatgcaa ggactctctg aatcttctca caattacgcc
     6121 tatccccggg agtgcgatcg cagcattctc accggcaacc atcgcactca gcatacccaa
     6181 cccgcgatcg accgcttcaa agagacccta ccgggcaaat ccgaaccagt cagtcgcttc
     6241 cacaagctag accccaaggg attatgtaat acattaagag caggaacccc cagcaaccgg
     6301 ggtgcttata cttcccctcg tcccattcat ccgtttgaac cccgttgtat taccgttcgt
     6361 gaggcggcgc gtctgcactc ttaccccgat tggtttcgtt tccatgtcac caaatggcac
     6421 ggattccgcc aaatagggaa ttctgttccc ccactcttag cgaaagcggt tgccgccgag
     6481 attatccagg tgttaggaat agcaccgatt tccccctctg tcccgaaaca actggaaaat
     6541 ccagagttgc taaaactgcc gatgtctgcc gcagcagcac aatatcacgt tgatccgcac
     6601 accatcgaac cgcgatcgcg ccgagcctca acccctaaaa catcagtata atagcagtta
     6661 gaaaccagat ttcttgtccc acttactcac tactcagaac ttatatcaag tctgttaaat
     6721 tcacctaaaa aaacatttcc tcctcttctc ccccttccag caataaaaaa atttccttat
     6781 tctccctctc cttttaggag agggccgggg agaggtggga agggggttgg ggggttaggt
     6841 ccctctgggc gcgcaatacc agtccatttg atctctatac tcgcccccag atgggccggt
     6901 tcatcaattt aaggccccac tccctctgct ggtgtgaaac cgtccaaaaa aatagggtcc
     6961 ggccctcgaa caggcgaggg catcggttgc ttgatagcta ctccacactc tgacgccact
     7021 taatgaccag atcagcgtag gagttgttta atggtttgaa tcagttctgc cggacgaaat
     7081 ggtttcgtga tgtaagcatc cgctccttgt ttcatccccc aataccgatc aaactcttga
     7141 cttttgctcg tacacatgat aacgggaata ttctgggctt tcgggtcgtt ttttaaccat
     7201 cgacaaagtt catagccatt cattcggggc atgacaatat cggtgacgac taaatcagga
     7261 ggcttggcct gaatttgttc tttggcttct actccatcag atgcttcaat cacttccaaa
     7321 ccgctttttt tcagaatgtc cgataccatt tctcgtaccg taccgctatc atccacaatt
     7381 agaattatac tcatcgctcc ctccgtattt tctggttcta aaggcttggc gtataattca
     7441 gcgttctttt aatgccaaga tgcttttggc aaaatgagtg aattattaag agtaaaccca
     7501 taaaacttaa caaggtgata ataatggtta ttctctaggc tcatagatgg tctgtcttta
     7561 aattgtcttg ctcgctactc ctttatattg ctctgatcgg tccaaactgg atgagtcgat
     7621 taaagaggat gcaccacttc gagacggctt gatctcaaat ggcactggcc ctggagaggg
     7681 catccctcgg ttcgagggta ctggtactgt atccgtcagg gttctgaccg gattcggttt
     7741 gacgatcgga ctagaggatg actagacctt tgccgaggga atccattgga tagaacgagc
     7801 atgagcaacc cttcgccctt ttgagatcac ttctttacat tatgggcagt aaaaacccaa
     7861 aggatctcta tcatcgcacg ggccaagctc agtgcgatcg ccaaattctg tttaacacag
     7921 agtcaagact acagtttaag agggagtcat tgaatgggac ataaccctgc ttaaacggct
     7981 taagcctgag ttgcctggac ctcttggctt ttatgggatc agccttccgg cctatgaccc
     8041 cacccaaccg aatcgatcgc cgattatatc attgaattta gggccatcga ctcaagggcg
     8101 atcgccattt cagcacttcc aaccctccgg catcgctatg ggatgcaatc catagagaag
     8161 tctctccctt tcccctctcc tcttaaataa cagagttcta ggattcaggg gaggtgaagc
     8221 aggacgccgc aaacatgaca gtttaatgac atcatattat caacctgtta tttcccagaa
     8281 aaacccgtga ggggaagcgg gaaaaaagat tgttggaact ccctaacaag aagttatgac
     8341 agttgcctga ggggattaga ggccatgagt ggcgatcgct caggggaggt ggagaatttt
     8401 attttgcaaa aacgaacgta aaaaagaaaa tgtaacagtt tgcaaaggta taatgagagg
     8461 caactcaaaa aacttaacac tatcttaaag aatctcaacg aggggattat taaccaatgc
     8521 gcgtggcgat cgcaggagcg ggtttagcag gactttcctg cgcgaaatat ctgactgaca
     8581 tgggtcatac ccccatagtc ctggaacgcc gggacgtcct tggggggaaa gtagcagcat
     8641 ggaaagatgc agacggggac tggtacgaaa ccgggctgca catttttttt ggtgcctatc
     8701 ccaatatgtt gcaactcttt ggcgaactag gcatcgaaga ccggctgcaa tggaaagaac
     8761 attccatgat cttcaaccag ccggaggccc cgggaaccta ctcccggttt gacttcccgg
     8821 acctgcctgc ccctctgaat ggggtgatgg caatcttggg aaataacgat atgctaacct
     8881 ggccagagaa aattcggttt ggcatcggcc tgatcccagc aatggtgcag gggcagaaat
     8941 atgtcgaaga gatggataaa tattccttct ccgaatggct gaaacggaaa aatatccctc
     9001 ctcgggtaga aaaagaagtc ttcatcgcca tgtccaaggc gctcaacttc atcaaccccg
     9061 atgaaatttc cgcaaccatc ttgctgacag cactgaatcg gtttttgcaa gaaaaaaacg
     9121 ggtcaaaaat ggcgttttta gatggatccc cgacagaacg gctctgtcaa cccatcgtgg
     9181 actacattac cgatcgcggg ggtgaggtcc ggttaaacgc gccgattaaa gagtttttgc
     9241 tcaacgaaga aggggcagtc cggggatttg aggtccgagg cattgaggga aaaccagagg
     9301 aaatcttgac cgcagatatt tacgtctcgg cgatgcccgt ggaccctcta aaagtgatgc
     9361 tcccccaatc ctggtggcag atggaatatt ttcagcaact caaagagtta gaaggggtgc
     9421 cggtgattaa cgtgcatctg tggtttgact gtaaactcac ggatattgat cacttgttgt
     9481 tttcgcgatc gcccttactg agcgtctatg cggacatgag caacacctgt cgggaatatg
     9541 ccaatcccga gcgatcgatg ctggagttgg tccttgcacc agcgaaggac tggatctcca
     9601 aaaccgatga agaaattgtc acagccacca tgaaagaatt gtccaattta tttccggatc
     9661 acttttgtgg tgacaaaccg gctaaattaa taaaatatca cgtcgtcaag acgccgaggt
     9721 cggtgtacaa agcaactccc ggacgccaaa attaccgtcc ttcgcaaatc acaccgatcc
     9781 ccaatttcta tctgacgggc gattacacca tgcaacgtta tcttgccagt atggaaggag
     9841 ccgtactttc tggtaagctg acagcgcagg ccattgcgag ccgtcagtcc cagaattaat
     9901 aaattttaga atttagatat tagtagtggc ctacaactca aaatccctga attcccaacc
     9961 tagaattctg gcatctaaag acgctccccg cttgcaacca atgctgcaac tgtccgaaca
    10021 accacgcatg aaaacgctgg cttccttaga cgacgcttat gagctctgtc gccaaatcac
    10081 agcgaaatat gcccgcacct tttacctggg tacgctgctg atgccagaag cgaaacggcg
    10141 ggctatttgg gcgatatacg cttggtgccg tcgcacagat gaattggtgg acggacctgg
    10201 ggcgagattt accaccccag aaaccttaga tctgtgggag ggttacctcg aatcgatctt
    10261 tgctggaact ccgatcgaag atactgatgt ggcgatggtg gatacggtgg aacgcttttc
    10321 cctggatatc cagccctttc gggacatgat ttccgggcag cgcatggatc tgtaccgcag
    10381 tcgctatcaa acctttgagg accttgagct ttattgctac cgcgtagccg gtactgtggg
    10441 cttaatgtcc ttgccggtga tgggaattgc gcccgtggtt cggtcctccc cttgggagtc
    10501 ttccgaacct gtggatccat cggcggaggc agtcgccctc ggcattgcca atcaactgac
    10561 caatatcctg cgggatgtgg gagaagatgc tcgtcgaggt cggatttatc tgcccctgga
    10621 agagctcgct ttgtttgact acaccgaaga ggacctcttg aacggggtgg tcgatgagcg
    10681 atggcagcaa ctgatgcgct tccaaattca acgcgcccgc aagttctatg tcaaggcaga
    10741 aaagggcatt ctcgccctga atcccgatgc gcggtggcct gtctggtccg ccacgatgct
    10801 ttacagccaa attctcgaag cgatcgaacg caacgaatac gatgtattta gtcagcgggc
    10861 ggtcgtaccc cgttatcgta agatgatctc tttgccttta gcatggctca gggcgcaagt
    10921 tctgtaagga aacctggttt agatagagat ttttggcgat cgcctccaga ggcgatcgcc
    10981 accccgccat caactgaacg caaaacatgg aagtttggcc taagctggca aacttccatt
    11041 ttttgtatgg acattttgac caacaaaatt gaaggtcctt ttaaatcaac ctcgtgcgta
    11101 accacaatcg aggtctagcc cggtttgtct tcatttacct cttcaggaag atgacaaaag
    11161 ccggaaaatg ggttgatatc aagagatata gagactgaac atcttttttc ctatctccac
    11221 tcaattcttg ctcgtttgtt tggcgcgaac ggctgatttt ctgcgcctga accgatgctt
    11281 caagatgagc ctaaacgagg ctgtggattt aggttacgag cttttccggc agataggctt
    11341 tatcatagat gacaagaaat ttatatttct taacaaatat taaagattta aaaaactatg
    11401 tgctctatga ctctcctaag cgatttgccc aaactgctga ttcagcccaa tgacccggat
    11461 accggaacct atctggctaa cctgggattt cagcccgttc cagcagtccc cttgctgctt
    11521 tatcgcatcg tgaccagaag ccaactgaag gaaatattct ggcagttgag caaccagctt
    11581 ggagagatgg ctcaaaacgc ctctcggttc gtagttaccc aaatctcctt agactcaacc
    11641 catctactgt tggaatttct caaagcacag ccgctgattt cagtgaccaa ttccatcaaa
    11701 tatgcatggt ttttgcgact gctgctccaa caagggctat tttttaaata tcaacccatt
    11761 ttttgcctga aatcgggtca gatcaccgct tatgaatgtc tggctcgtgc cttgggggat
    11821 tctggacagt gctacagtgg cggaatgtta attgaggcag cgatcgccac agatttatcc
    11881 caggaatttg atgaactggc gcggacaact tgtattgaat ctattgccga gttgaacagc
    11941 gatcgccagt tttttgtcaa ccttttaccc aatgccatta ttcaaaatcc tgactccatc
    12001 gagcagaatt tacaacaaat tctggattta ggattccgcc cggaacaaat catttttgag
    12061 ttaaccgaag tggaagtttt agctcaaagc gaaaaactcc cgcagcttat tgaacggatg
    12121 cgcgcctggg gatttggaat tgcagttgat gatctgtgtg gctgtgtctc tgtggatcac
    12181 tatgcaatgg agcttagacc cgatattgtc aagttagacc gacgtttgat ccaaggttgt
    12241 agccagttca ccttgaaaca gactttaatc aaaagtgtgc tagagtccgc gcactccgag
    12301 ggaattattg ttttagccga aggcttagaa acgattccag atatccaatt ttgccaggag
    12361 ttgggggtag atttgggcca aggatttggt ttagctcgtc cggaggcgca cctccagcaa
    12421 cagccgtttg agccttggga tttaatgatg tctaaagcct cttagggaaa ccgcgatcgc
    12481 ttcttttgtt agagatgccc agggattata cagtatgaac agccgtttgg ggtggttgta
    12541 aaccaatttc ttcgggcaat cggaccgatg gactctcccg gaggcgatcg cctcaaagaa
    12601 tgccctggct tgaattctac caacccaaat aaagaaccgc gatcacaaaa gatgcgatcg
    12661 cggaaatatt ctgaagaaaa acaatccatc ggatttttcc ccctctaact cgtcaccttg
    12721 atgcagattt agcgggaaat tccattgaat taggagttgc tggcttgagc agccaacatt
    12781 tgtttgagct tttctaactc cccagcccaa cgaggatccg gttgtaccga atccgagtcg
    12841 gggctgccac tgccactgct gctgctgcta cccgtcgagc gtttcgactt gttgttgccg
    12901 cgagcaccac ctccaccgcc tccggtggtg ggtttagcca ccttacttgc tgccggtgtg
    12961 ggtgtgggtg tgggtgtgct agtcgccgtt gcctcatccg tctgtgaggg gggtgctcct
    13021 tcttgttcct cgtcaccttt ccccttcttg cgaggcaatg ccttttcaat cttcaaaggg
    13081 gtatcttgga acatataacc gttgaacttt tcgataaatt cgtcggcttg ctcgtcattc
    13141 ttcactgtga cgaatccgaa cccccgacac ttgcccgtct tgcgatcggt aatgacttta
    13201 gtggtcacag aatcaccggc ttcagcaaag acgtcttgca gttctttgcg atcgacttct
    13261 tttggcagat tacctatata aagacgaatc gacatttgag atacctccta tcttttggaa
    13321 aatcaattaa agacaaaacc ttcttttttg actcaatccg tttgttcggg gcttggtcgt
    13381 taaggactta aagcgagagc tttcctgtct tctcattacc ctttgatcgc acaagggtaa
    13441 aagtaacggc ttggctttta tcaatcggtt cacagttgtt gctctctcca ccccagacat
    13501 accctatcga aaaaaatacg cgccaataca ttgcctcgaa cgcttgtaac aattcggtga
    13561 aattttaggg agggcatggg atctttcaag attcctttct tctgcttttg ataaaaatct
    13621 gctttaggaa acatatcctc tctgcggagc ttctcaagca cagcagagta tcctaccgtt
    13681 ctccttaata ccacctatgt aaacttcaaa cggctcaagt gtaaagttga tgcgtttctc
    13741 aatatgggcg ctctcttact tactctaaca gaaatgggtg attatctccc attccattac
    13801 tttttttgac ctcaatcgag ccactcctta aaatatcaca gcttatgcag gtgagctagt
    13861 agttggctca atttttttta atttcccgac tataaatttt accattagct gatcactgcg
    13921 gaatattttc cccataaacc ccccattttg ttgccggttt caactttttc tcagtttcga
    13981 gggaaaagcc gcccatttgt tagaccggac tttaaaggga cctctatccc tgtaaaagca
    14041 attctcgaat cgcccctaca gatagggttc ggtctccaaa aatgcgtaaa tcctgttaga
    14101 tttgctaagg tctccttggg tttgaaggag tcaaccctga ctcccacccg gagattgagc
    14161 aacggtaaaa cgagtgtttt ttccagattg gcccccactg ctcaggtttc attaagaatt
    14221 gtaacaaatt ccggacggat tctgagacct tcctggaact tggggccaaa ccgtcgtccc
    14281 cttggaaaaa catcaatacg gaatccggtt gtcaaaggtc tataaaatcc cacaccctaa
    14341 agggtggggc tatacagacg aagcccgcct gcgcgggcta atccagaaaa ttgacttttt
    14401 acaaccggat tgggtataag ggtattccca caaataaatc atccaaatct gatagttaag
    14461 catcccacaa gactctattt agcccgcgca ggcgggcttc gtctgtgagc ctccaccctt
    14521 cagggtgtgg gttttttgga cattttattt tttggagttc cctaagaaga cgatcgccac
    14581 cgcaacagtc ccgaatttag ggcttgagtt ccaatattgc ggaagtcctg gcccactcct
    14641 agaccccacc tttagacatc cagtacaccc cgacaagtgc cgccactgcc gccaaaatcg
    14701 tagaccaaat gggatgacca ctggagtgag ttttaccctc agccgtggtg aagcggtcca
    14761 gatcaatcca gggagtcgca ccccgacgga accaaccgac tgccgaaatt ccctgtccca
    14821 cgacatcatt aggacgctta gacaaaagcc atagatatcc aaaaaccccc agatttgagg
    14881 cggcgtgcaa cttcactaat ccagtcgggg actgcaaaat taaatcttgg gccagccaat
    14941 tgctaagtcc gcgccgtccg agaagttgtc cctccaaacc aatcggtaaa ctatcgacgg
    15001 ggatggcatt cggatccgtg aggagttcag gtaaaggggg gttggtgcgg atatttttag
    15061 aggtaatgtc tgggaaaaag gaattaatcc gcagaaaaat acccaaactt acaccaatta
    15121 atacagaacc ctggagaatc gagcgatcgc cccacaccca atccagggca acaaacccca
    15181 ggtttactgc aactgcccca aatacccaca gcatcaaccc ggcgagtaaa cccaggggaa
    15241 gaccaaaata gggtgcacct tgtaataaca ggcgtttgag catcgccggg gaagattttg
    15301 ccggggccac tgtgccatcc cgggcaaaat ccaactcggc atccagcttc caaaaccgag
    15361 catataaatc taacagggtg aggcgatcgc ccaaaggcgg atgagattgg ggaaccatca
    15421 accatttttt atagccattg tggcggtccc actgcaagag attttcccaa gactcaaatc
    15481 cagaacaact ccccaaggtc atcccttgca catagccgac cggcgagagt aaatcgaatc
    15541 cttccagcac aaaactggta tgaccctgtt tctcaacatc ctgagcaatt ccaatggcca
    15601 ttttcagtaa agcgcgagtc agagcattgg gattgccagt taaagaggca gaggcgcgat
    15661 cgctgtaata aaaccgcaag cgcgacagga ataaaaccgg ccaacgtagc acccagtaca
    15721 acccataggc gactgctgaa atcacccctg cggtccctaa catcaccttg ccggaccact
    15781 cctgagagtc caaccactta tccccatccc gggacacctg ccaatagacc aaatagggaa
    15841 cttgacagag taacaccgcc aaagacatca ggggaaaatc ccaattttct aaatgcccta
    15901 actcaccggc ataaattgcg gcaatttcat cttcctctaa ttgctctaat aacccttgac
    15961 tgaccacaat tcgggcaaac cgaggggcaa aaccataggt cattgcgatc ggtgcatccg
    16021 tgggaatcac ccccaaggat agggctggtt gcttacgctc cacactaaag cgggatagca
    16081 acttacgcgc ttctggacta tagttaccca gttttggtgg cgggagtttt tccatgccgt
    16141 aagcaaagcg cagcagtaaa tccagcaacc agggtgaggc aacaagcaac aggatgagga
    16201 tgcccaacaa ggtccaagtt tggtctcgat aaaaactttg gatcggccac aacaagggga
    16261 gtcgatagaa caggtcatta gtcgttgcca tcccccaatt catgaaaatc cgcagcaacc
    16321 aaaacagggc gatcgcactg cccatttggg caaaccctag ataggtgggt ttgacgggtt
    16381 tgagttttcg ccagttttgc gcccgtcccg cctgacgcca ttgccgaggt tgtggagtcg
    16441 gaagcgttac tttcaaagga gtcgcgtcgg gttgtctctc ctccgatgcc tttgccgaag
    16501 gtgaatcagc cttttttgtt gacggggtta aataatctat ctcctcggga tcggcttcta
    16561 aggggaggac ttgtggagaa tcttgccggg gaaccggggg tctggggggc attggcggcc
    16621 ccggtggcaa tgaggctgga gttaagggac tgactcctgg ccggggggtt gctcctcctg
    16681 ggggtctggg tggcatcggt ggcgggttga ccggggaccg ggacacaggt ttagtttgag
    16741 ccggttctag ggggacaaat cccgtgggat ttcccaggga caggggggaa atgatgccct
    16801 gggagttggg gtttttgagg ggtgagggtt gagcaggtcc tgaagatgat gggtctaatg
    16861 gcacaaatcc ggtgggattt cctctgaggg gggagggcgg actgccagga cgattgactg
    16921 ttttcggggt ttggggttga ggctccggcg atgaaggagc cgatcgccct tggggagagg
    16981 gttgattgaa ctgagccagg gtccgaaccg cccagtcttt aactttggga ctgtccgatt
    17041 cggtcaaggt ttgacataag gcaacagcct tggagagagt gcggttccct ttataggcca
    17101 ttaccaatcc catcgtcgcc cgatcaaccg tgggttgatg gagttcttgt tcacagacct
    17161 tttctaaaat ggcgatcgcc attttatagt cctttttttt gagcgccgcc aaccctgttt
    17221 ggagatccga gtgttccata gccatcgatt cacaattggt agatgaacca agaggttcaa
    17281 cgagaactag agagtcagaa tcgagaaggt ggggattgtt cagtctcgat tcttaaatgc
    17341 tctatagtca gtttaaatca ttcccacctc ggatctgtgg ggtgtcccaa ggggtgcaag
    17401 ggtctgagag gttttggcac cgggtcgttt tcccgaggtc gaggtgagtc atattcggta
    17461 ccttgctcgg tttgtcaaca gtcttgagga gtgtggacat catcaatcaa atcagggggg
    17521 aatcataccc tcggatcaat ggggctgtcg caaaattaag atagattgaa aggcaacctc
    17581 attctggatg ggtggcgatc gcatcctatc cctagggatt tttcacggaa gtttaatcat
    17641 aaaaggagtt caagtcatgt acgatgcaga caaacggaag ttgttatccc tgctgtctca
    17701 tgcggcaatt tttctgagta caaccttggt gtctattggt atccctctgg cgattttatt
    17761 tgtatccgat gacccggtag tcaaagataa tgccaaagaa tctatcaatt tccatctgaa
    17821 tgtctgggct tggggttcgg taatttttgc cctcagtttt ctgacctttg gcttgttggg
    17881 atttattctc gctccagcgg ggtttattct ccattgggga ttgacggggt ttgcattgct
    17941 gaaggtgttc ggaaatccag accaaccctt tcagtatccg tttattttcc gcgtgttata
    18001 acttgagaat caggcgatcg gcaatattgg aggaattttc atgtacgatt cagataaacg
    18061 gaagttatta tcggttttgt ctcacggagc catttttttg agcgctacgg ttctttccgt
    18121 cgggttgccg atcgcaattt tgtttctttc tgaggacccg gtcgttaaag ggaatgcccg
    18181 agaatctatc aattttcatc tcaatattta tctctatggc ctcatctttg gcctcttggc
    18241 tgttgtcctg attgggtttc ccctgctgtt aattttatta gccgccagtt ggattctgcc
    18301 gattgtggcg atcgtgaagg ttctctcaga ccccactttg atttaccgct atccgttcat
    18361 tttccggctg gtttaattaa accctaataa aatcagcaat taaccccctc aaatgacggc
    18421 tttttcgagg aactattccc caaatagagc cgaaaggatc gggaagactc gggtttgaga
    18481 tagccatgac aggaattgcc ttttaaggtt gactccccga tggcaagcgc caaattttaa
    18541 tggtttcatc cggagaaccg ctcaagaggg ttttcccatc gggggtcatg gcaattccac
    18601 tgacataact agaatgaccc gtaagctgat gtcgcagagt tcccgtgact aaatcccaaa
    18661 tttcgatcgt ccccccacta cttgccaaga tgttgccatc gggaccgatc gccacggacc
    18721 tcacccaact ggaatctcca atgagctgat agcgtctttc tccggtgctg agattccaaa
    18781 ctgcaatggt attatcgcga ctgccactaa cgagggtgtt accatcggga ctaatggcta
    18841 gggaaataac gggatgaaca tgaccgcgca gggttaacaa tctcgcgccg gtggctaaat
    18901 cccaaatttt taccgtattg tcattggcag cactaataat tcggcggcca tcgggagtaa
    18961 aggcgatcgc attcacccca gatccaacct gaatggtgcg gaggcgagtc ccacttctaa
    19021 tgtcccaaat cttaatcgta ttatcatcag atccactggc taaccgctga ccatcgggag
    19081 taaaagccaa ggtattcaca ggaccccaat gggccccggg tccagcaatg gtgagcattc
    19141 gggacccatt attcatgttc cataatcgaa tcgtcttgtc agcggaacca ctggctaagg
    19201 tctgaccatt gggactcact gccagggtcc ttacccagtc tttatgagca gctatagtgt
    19261 gcagtaaggt gccactgttg agattccaga tgcggattgt gccaaaactg ccgctggcaa
    19321 aggttccccc ttccgattga ctggcagcgc caggaagctg actcatggcg atggactgaa
    19381 cttgacccac ttcccggata cttcttctta aaaacaaact gctggggaga ttcaccagga
    19441 gtccgacggg attggcggga aataatccat atcgccaata gccatagact tgagaggttg
    19501 ccaggaacac taataagata gcgatcgccg aaatccaggg ttttttactg cctcttttca
    19561 gaaattggct tttaccgcta ttcttgcttt tcgcagggta aacgggttgg tattgcgatc
    19621 gcagctttct cgattccgta gcgggtgatt tcgtgttgct atgggaacct gtattgtaat
    19681 tgccccgagt tccagaagtc cctattccgg tgttcgcctc ccccacttca ccgttcggcg
    19741 gtgtcaaatc aatctctgcc agacattgca aaatagcctg agcactttga ggccgctttc
    19801 ccggaaaagg ggccattaaa taatcaatca catccccaaa agacttggaa atctgcggtg
    19861 cactattgcg ccagacgagt tttcccgtcc gaggattttc cgaaaaggcc gtagggggtt
    19921 tcgccgttag caaaaagacc agggtccggc ctaaggcata aaaatccgat tgcgggaccg
    19981 ccttaccatt ggcttgttcc ggtggcgtat agcccggaga gacaatcccc gtaatgtttt
    20041 gaccctgccc cactttcgca aagtaggtat tcgtgacttc ccttgccgcc ccaaagtcaa
    20101 tcaacaccac ttgtccattc aagcgaatca tgatgttgag gggcttgata tctcgatgga
    20161 aaaagttttg ttggtggacg cgatcgagaa tctccaccat ttgttttaac caatcaaggg
    20221 cttggttttg agttacgggc cgatttcccc gctttttcat ccaatcccgc aggttcaacc
    20281 cactgatttt ttccatcact aagcagtgga tcggttcagt ttcccccgga ggcgtgattg
    20341 caaagtaagc atctgcctca actttgggaa tccccggatg gttgatccgt ttgagcacat
    20401 cggcttcctg ttgaaaaagc tctactgcct tttcgtggtt ttgaagcaat acttttatga
    20461 ccttgatgac gccttggtca tccacttcaa aagttttacc aaaacctcca ccgccaaggg
    20521 gtttgataat ccgataccgt ctttgcagga gtacatcaca gccacagtga acgcatttga
    20581 catggttcgc attggctggg tcattaggat ggggacattt gggattcagg caataactca
    20641 cagaagctac attaccctat aattctgact gcacgtctca acaacactat aacttgcagt
    20701 tatcattcct aactgtaggg tcttgccaac ttattggcaa tttcctcggt tacttgaccc
    20761 tctagctgca gtagtggtgg aacccatctc ggtagcttga ttgattgacc tgctgttctg
    20821 ggccgatggg ttaacccgtt gggcttctag gaaaggtcat ccgtcgaagc ctgttgtgac
    20881 acctccatta aagattagca atgatccggt atcaaaataa ttgggtt
//
