LOCUS       NZ_JH941046            24736 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold10, whole genome shotgun sequence.
ACCESSION   NZ_JH941046
VERSION     NZ_JH941046.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 320856)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 320856)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Draft Genome Sequence of Streptomyces sp. SS, which produces uridyl
            peptide antibiotics sansanmycins
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 320856)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 11283
            Orig. end                         :: 36019
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JH941046.1.
            Bacteria and source DNA available from: Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24736
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="blactam"
                     /region_number="1"
                     /rules="(BLS or CAS or tabtoxin)"
                     /tool="antismash"
     cand_cluster    1..24736
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(BLS or CAS or tabtoxin)"
                     /kind="single"
                     /product="blactam"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24736
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:14736](+)"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14736
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(BLS or CAS or tabtoxin)"
                     /neighbourhood="10000"
                     /product="blactam"
                     /protocluster_number="1"
     misc_feature    456..469
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.97"
                     /tool="antismash"
     gene            complement(463..1257)
                     /locus_tag="Y19_RS0130160"
     CDS             complement(463..1257)
                     /GO_function="GO:0036361 - racemase activity, acting on
                     amino acids and derivatives [Evidence IEA]"
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241258.1"
                     /locus_tag="Y19_RS0130160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_017241258.1"
                     /transl_table=11
                     /translation="MKIALMDSGIGLLPAATAVRRLRPDADLLLSNDPDGMPWGPRTPE
                     DLTERALAVALAAAEHRPQALIVACNTATVHALPALRAALEPHIPVIGTVPAIKPAATG
                     GGKVAIWATPATTGSAYQRGLIRDFADGADVTEVPCPGLADAVEHADQDAVDRAVAAAA
                     DLTPTDVRAVVLGCTHYELVEERVLAALAARRLPGLPPLVFHGSADAVAAQALRRIGAE
                     PAPDADPTGTLSVLLSGRPGQLPGTALTYAEGRLLAATAPAH"
     gene            1274..2595
                     /locus_tag="Y19_RS40575"
                     /pseudo=""
     CDS             1274..2595
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009713308.1"
                     /locus_tag="Y19_RS40575"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /pseudo=""
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.8e-16,
                     bitscore: 54.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTVHPSIWGRLPRMSTLAWFAIGSLAVWVWLLLGQGFFWRTDQR
                     LPPTAARLATGGRLPPTAPPLPAAGGREPASARRRDADGSPGAGPPERWPRVAVVVPAR
                     DEAAVLPLSLPSLLAQDYPGRAEVFLVDDGSTDGTGRLAGELAGRLGGLPLTVVSPGEP
                     EPGWTGKLWALRHGMALARAREPAPEFLLLTDADIAHDPRSLRLLASAAVEHDLDLVSQ
                     MARLQVVSVWERLVVPAFVYFFAQLYPFRWINRARPLATAAAGGCVLLRTETAVAAAVP
                     DSIRRAVIDDVSLARAVRRAGGRIWLGLADHVDSVRPYPGLGELWRMVSRSAYTQLRNS
                     PLLLAGTVAGLVVVYVVPPVALLAGAAAGDGAAAWAGGVAWAVMTGTYLPMLRYYRQPR
                     PSPPSSTC"
     gene            complement(2670..4301)
                     /locus_tag="Y19_RS0130170"
     CDS             complement(2670..4301)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952514.1"
                     /locus_tag="Y19_RS0130170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_017241259.1"
                     /transl_table=11
                     /translation="MALNAEARGTVNPSDHRGGTLRYVRTDDFDSLDPADTYYAYTWNF
                     IRLIGRPLVGYTTDAEGAPSLVPDLAEALGQASEDSRTWTYRLREGVRFEDGTPVTSQD
                     VKYAVLRAAFPEEVYDATVTRGGPAYFRQYLTGPEGIETPDDRTLVFRLRRPFAAFDYL
                     AALPTTIPVPRDHDTFPEYHRRPLSSGPYRIDTYTPGAELTLDRNPHWAAETDPVRTAR
                     PDRITVRLGVSGPEVDRILVDGEADIDLAGVGVQPETQERLLADPELRQHVDNPRTGFV
                     WLYCLNQNVGPLTSLHARRAVQYATDKAAMLAAYGGDPAGEIATTLLPASVVGYDPFDR
                     YPVGPEGTGDLEAARRELALAGLPDGFTTRIAAREDRRKEWNAALALSRGLARVGIQAE
                     VVPFTSGDYFTKAAGVPAYVREHGIGIVMFGWAADFPDGYGFLQQIADSRAIKETGNQN
                     LGELASPQIDALLDTGAATRDDKERARIWAAVDRAAMDEAVMCPYMYVKSVVFRGPRAA
                     NVTMSPAYGMYDYAVLSVADEDPSAG"
     misc_feature    4318..4335
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            complement(4383..5435)
                     /locus_tag="Y19_RS0130175"
     CDS             complement(4383..5435)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Y19_RS0130175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_017241260.1"
                     /transl_table=11
                     /translation="MTVFLTAVDPGDRDVVGDVYDLRLAGHAADVPHLPRPCPADLEGS
                     LTVAPPATEIEEWAAYSAGGRCVASVRLEFPLEENSDAVTASVLLVHPAFRRQGVGKRI
                     TEFSRDRAARRRRSRVLLVADAGPGDPAATPGHRFAARLRARALVRYEHLRLRVDDAPR
                     PTPPPEHLRLRFWGSTVPEELVTQAARLEATLSADAPAGQASWEPQPNAVSRIRDFERM
                     RIARGRRAYQCGVVDARTGRMAAWTALSMTRANPDNALQAVTVVDPAYRGQGLGLLVKA
                     HNLAACRAAEPRLTVVDTWNASDNTHMIRINTGFGFTRAGTRGMWELSARRSPARTGSD
                     LPRPLTSGLS"
     gene            complement(5432..7060)
                     /locus_tag="Y19_RS0130180"
     CDS             complement(5432..7060)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003961820.1"
                     /locus_tag="Y19_RS0130180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_017241261.1"
                     /transl_table=11
                     /translation="MSGWNGAVKSVANPGGSPGGTLAMVASADVDSLDPARTYYVWSWL
                     LQRTMHRTLMAFGTDPATPTVVPDLATGPGEVSDSGLTWTYRIRDGVRFETGEVIRARD
                     VAHAVERIFAQDVLPGGPTYLLDLLDHGDYRGPYGGQSCRAVECPDDHTLRFRLKRPFA
                     DFDFLMAQPNTAPVAAHHDTREDYEKAPVCSGPYRIGSYRAGHSLHLVRNPMWDRATDP
                     LRSALPDDMTVTFGVDVNELDRRLMAGEFHIDVEGRGIQHSARDVILADPALRARSDNP
                     ATGFLQYITVQTCVPPFDNVHARRAVFYAADKAALLEARGGDGVGGSLATSLIPPTLPS
                     HTGHDRYPSGTDLTGDLKAARAELEAAGLPDGFETRIATQPGKFELVARTLADAVARVG
                     IRVHVEVLDTASYYRSGLGHPDTVRALGLGLGVSDWGADYPTEYGFLAPLVDGRQIKPG
                     GGNFNFAELDDPVVRRLVDEAQALDDPEARQRLWQRVEETVMERAVILPIAHDRTLHYR
                     HPDVTDVYVHPAFGLYDIQAMGLAR"
     gene            complement(7060..8142)
                     /locus_tag="Y19_RS0130185"
     CDS             complement(7060..8142)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016242.4"
                     /locus_tag="Y19_RS0130185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_128643828.1"
                     /transl_table=11
                     /translation="MTSRVVINQWQTPEDAREAGWNALVGAEDFFLSPDWMRVLQDSAG
                     AWMGYLTARTDDGLQAALPMVRATLDSPWSLGRTDLLVRHCADEGMDGAAEVLAGFGDM
                     ERLMPSMMGGGRHLGRTRLMLGPGAGPETAHRILEEAERVAAAEGCRSVCLPYVDASDG
                     VQRAVLRERGYLAHESGQFASLTLPGEGFMDYALALPARRSRRVRSERRHIEASDVRIT
                     LAPLDPADIPRLGALETRLFAKYGMTSWDPKRSEAVLTAAAERLGDRALVAKAVLDGSI
                     VGFGLVLAHGDSWFAHRAGFDYEAVGKLPLYYELLYYTLADHAPRHGVKTVHYGIGSTD
                     AKVSRGCSLSAQYLYVKEIG"
     gene            8278..9999
                     /locus_tag="Y19_RS0130190"
     CDS             8278..9999
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090800.1"
                     /locus_tag="Y19_RS0130190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_017241263.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1e-43, bitscore:
                     143.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.5e-35, bitscore:
                     114.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVSTGPSEQPTTAHALLKRLREHGVEKVFGVVGREAASILFDE
                     QDGIEFVLTRHEFTAGVAADVLARITGRPQACWATLGPGMTNLATGMATSALDRSPVIA
                     MAAQSESHDIFPNDTHQCLDLVKIAEPISKYAVELERPHEITDLVDSAVSAAMTEPVGP
                     SFISLPVDLLGSSEGIDLDKDHGPALTPEKPITAIQPGWELRADQAVALVREAAHPVFV
                     VGAAAIRAGAVPAIRALAERLNIPVITTYIAKGVLPHKHELNYGAVTGYMDGILSFPAL
                     ESLFGPADVILTLGYDYAEDLRPSMWERGGEKKTVRVSPTANPVPRIYRPTVDVVTDVL
                     AFVNHLDAGTADVEAKDRHEISAVRERIAELLSDPESYDDGMRVHQVIDCMNSVMGETA
                     EDGEGTIVSDIGFFRHYGVLFARADQPYGFLTSAGCSSFGYGIPAAIGAQMARPGQPTF
                     LIAGDGGFHSNSADLETIARLNLPIVTVVVNNDTNGLIELYQNIGHHRSHDPAIKFTGV
                     DFVQLAAANGVEGARATTREELLAALRKGVELGRPYLIEVPVNYEFTAGGFGALKI"
     gene            10001..11524
                     /locus_tag="Y19_RS0130195"
     CDS             10001..11524
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: BLS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952510.1"
                     /locus_tag="Y19_RS0130195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_017241264.1"
                     /sec_met_domain="GATase_7 (E-value: 6.5e-13, bitscore:
                     42.9, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="BLS (E-value: 4.9e-151, bitscore: 497.3,
                     seeds: 11, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2.3e-27, bitscore:
                     90.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQTDLPAAFGFLASAHTGGGSIPAAVFATRGRHTRLSERLRALS
                     VDAVLVHPDAGPSGAHASDADTLVLFAGEIYNRDEIDDTLDSPANASDAERVSGLFEKY
                     DLHAFRLINGRYAALLVTGTRVLAATDHAGSVPLYVRPDPGHVLAATEVKGLAAAGAAV
                     RGAPVAGARRVRRTPGVHQVPAGAVLDIRVDTGDATVHRTWVPPVHRLLTGETEALNNV
                     RAALERAVVRRLPDGGRPLVVLSGGIDSSAVAALSASVATAGMDTLSMGTDVSDEFPQA
                     RVVAEHLASRHRELVVDSRDLLALLPHTVYAAESLDPAVIEYLLPLTALYRRIDGPPRR
                     ILTGYGADIPLGGMHREDRLPNLDTAVAFDMDTFDGLNEMSPVLSAVAGHWSTHPYWDR
                     EVLELLTVLEAGLKRRYGRDKWVLRAAMSDLLPAETVARPKLGVHEGSGTTASFSLLIR
                     QAGAAEDDVAAVKARVVQELFDLTVVGGVDPDEIVVEEIIGKIVAEGRR"
     gene            11521..12801
                     /locus_tag="Y19_RS40580"
     CDS             11521..12801
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009997519.1"
                     /locus_tag="Y19_RS40580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_017241265.1"
                     /transl_table=11
                     /translation="MTTYEGFQGKRLAVVESMLHDAFYSGIHRARDFGCEVWLLVQGEE
                     WYTGGGPLAEHPLGKVDRVLHVDTHDWRAVADVLTDDDGKPLVDGVLSFSDYHTEATAR
                     AAEALGLPSQGLEAVRAANHKHLLRSALGEDPANVRWRLVTCADELDEAISHVGLPLIA
                     KPPSEAISYGVRKCGTRAEAVDAWRELSGIRQSLRGQPRPGYVLLEEFVRGTEISVESM
                     TVDGVTHFFGATSKYLHKQTMLEEAHSFPLALDPDVWEAVRSCVDRTLRAVDYRQGPAH
                     TEVMLTEDGPRVVEVNPRLPAHMISTMVTDVCGTNPHLDAKLLALGLGHVPDGKPGQGV
                     AGGAAVVVLFPEESGEFTHIDGIDEAERLGVSVRLHHEPGDLVAERLDNSASVGFVYAH
                     GSTAEDALDKARRAAARIHIHTRRTAP"
     gene            12855..13757
                     /gene="speB"
                     /locus_tag="Y19_RS0130205"
     CDS             12855..13757
                     /EC_number="3.5.3.11"
                     /GO_function="GO:0008783 - agmatinase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008295 - spermidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="speB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952511.1"
                     /locus_tag="Y19_RS0130205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="agmatinase"
                     /protein_id="WP_051034235.1"
                     /transl_table=11
                     /translation="MRLPHDPAPQGADVVVIGAPYDGGTSYRPGARFGPQQIRTESGLI
                     HGVGIDRGPGVFDLIRVVDGGDIDLTPFNQHIAIQTAQERLSALLADNSAFLMLGGDHS
                     LTLSALRAVHGRHGPVAVLHLDAHSDTNPAMIGGEFHHGTPFRHGIDEGLVQADAMIQL
                     GIRGHNPKPDSLDYARGHGVRIVTADEFAELGVKATADLIKERLGDRPVYVSVDIDVFD
                     PAFAPGTGTPAPGGPTSREVLALLRTVGELNPVGFDVMEVSPVYDHAGITSLLATEVSA
                     ELLFQYARAHQTKKREEES"
     gene            13759..14736
                     /gene="cs1"
                     /locus_tag="Y19_RS0130210"
     CDS             13759..14736
                     /EC_number="1.14.11.21"
                     /GO_function="GO:0033758 - clavaminate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0033050 - clavulanic acid biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (47-299). E-value: 5e-20. Score:
                     64.3. Matches aSDomain:
                     nrpspksdomains_Y19_RS0130210_TauD.1"
                     /codon_start=1
                     /gene="cs1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     blactam: CAS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152698.1"
                     /locus_tag="Y19_RS0130210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="clavaminate synthase Cs1"
                     /protein_id="WP_017241267.1"
                     /sec_met_domain="CAS (E-value: 5.2e-177, bitscore: 582.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="TauD (E-value: 2.5e-19, bitscore: 64.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAILDVTEHQDLLLSLASRLPAVPRQDLYGFLDAAHKLAQELPYE
                     VSDTLDAFNQVGNEDGYLLLRGLPVEPEDELPATPTSTPAPVERGRLNMEAFLAIIGRR
                     LGLHTGYAELRSGTVYHDVYPSPGAHHLSSETSETLLEFHTEMAYHTLQPNYVLLACSR
                     ADHERKAQTLVGSIRKALRLLDEETIDRLYDAKQPCEVDVAFRGGIEDPGAIAKVKPLY
                     GPQDDPLLGYDRELLKPHEGADAEAVAKLSQALDDVTEGVFLTPGDLLIIDNFRTTHAR
                     TPFSPRWDGKDRWLHRVYIRTNSQGQLPTGGERAGDVITFTPRR"
     aSDomain        13900..14655
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Y19_RS0130210_TauD.1"
                     /evalue="5.00E-20"
                     /label="Y19_RS0130210_TauD.1"
                     /locus_tag="Y19_RS0130210"
                     /protein_end="299"
                     /protein_start="47"
                     /score="64.3"
                     /tool="antismash"
                     /translation="DTLDAFNQVGNEDGYLLLRGLPVEPEDELPATPTSTPAPVERGRL
                     NMEAFLAIIGRRLGLHTGYAELRSGTVYHDVYPSPGAHHLSSETSETLLEFHTEMAYHT
                     LQPNYVLLACSRADHERKAQTLVGSIRKALRLLDEETIDRLYDAKQPCEVDVAFRGGIE
                     DPGAIAKVKPLYGPQDDPLLGYDRELLKPHEGADAEAVAKLSQALDDVTEGVFLTPGDL
                     LIIDNFRTTHARTPFSPRWDGKDRWLHRVY"
     gene            complement(14844..16133)
                     /locus_tag="Y19_RS40585"
     CDS             complement(14844..16133)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="Y19_RS40585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_017241268.1"
                     /transl_table=11
                     /translation="MSTGRKTDDSARVPPSGTGEAKRPRSIPRGEGVGWFGTAALVNAI
                     GTGFFYPYQLLFFVAVTDLSLTTVGAGLTAATLIALPAVFMVGRLVQRWGPRTVLIVAA
                     LVRAGVFVGYLFIHHIATFIALAVVAAVAQRAEQISMPVLAAGTAPAEEVGLWLALTRV
                     SFNLGMGFGGLLAGFVFVGVDDGSGYTVMGLLNAASFALAALLYLPLAAVRPASSQKTG
                     RTGGPWRDGLFLRLALANFALITVIVATEVGLPVYLIEELRAPSWTVGLVFAVNTVLMV
                     LFQLPITGRVEGRAPLRVIALGSVLHAALLAVLGLAGVLSFAALLPLLLLGVSIYTLGE
                     ILATQALSVLLVKLAPEREIGVYQAFNQVLVGLSLAIVPLLVAFLLTHTAAGLWWLLTA
                     MTVALSLGMLSLHRTSATAVAGATPAPSGS"
     gene            complement(16130..16963)
                     /locus_tag="Y19_RS40590"
     CDS             complement(16130..16963)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="Y19_RS40590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_164875199.1"
                     /transl_table=11
                     /translation="MRIAVLGPLEVRVGSDLVTVPGHRQRGILAALALQAGRVVAAGHL
                     IKSVWFDKPPRTVMGQVQTGIWMLRTTLINAGAPADVVQSCATGYRLNGEVCSVDVASY
                     RAKVAEARTMHRRGRLDEAARLVRSAHELWRGPALADLTHQGLRSWSTRLDEEHIVALQ
                     YRASLELQLGRHEEVIPELFELVDNYPLRESLHADLMLALYRSGRQADALEVFHGVRQT
                     LADELGIDPGPGLRTLAQAILCQDSRLTPRPAASQPPLHAALSAHASSFSGGDPL"
     misc_feature    complement(16391..16393)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17821..17834)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            17824..18726
                     /locus_tag="Y19_RS40595"
     CDS             17824..18726
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579742.1"
                     /locus_tag="Y19_RS40595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_128643832.1"
                     /transl_table=11
                     /translation="MFLQWLGVAGWEIRCGDARLLFDPYLSRMPFQASDGSLDPSLPLR
                     WDRKAVASVADRHLSGPPDLILLSHGHFDHVADVPQLLAHREWSGHRIRTLCDETSHHL
                     LAAMGTPDARLADVIRVRGGEHLRFPGFTVEVLRSLHSQFADHGYFAPGTLVRRPRAPR
                     TIGDLVEGLTLAYVVSFDDGPSVYLSGTSNLAERELTGSRPDVALVGMTSHSAVHRYLD
                     RLQSALGEPAVLVPSHHDDMVSPLLPADEARRAGGNPGRSAAALALEEAAAARGAHGTR
                     VVDPAPLRPFEPTTPVTAK"
     misc_feature    complement(18820..18830)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    18821..18831
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            19302..20351
                     /locus_tag="Y19_RS40600"
     CDS             19302..20351
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="Y19_RS40600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_128643834.1"
                     /transl_table=11
                     /translation="MRKRPIMIVADLARAVALGAVPVLWALDALTVAHLCAVAFVIGVA
                     TVFFDVADQSYLPHLVGSEGLVTANARLVVVDQTAAVAGPGIAGLIVQAVTAPAAVLVS
                     AVAYVGSALCVARIKDPRPEPVDRTPRDRLGRSILQGIRYLWDHPVLRWLLACSTTMTF
                     FWSMGYGMLLVLLAQDLGVPAVTLGLLFTAGGVGGLCATAVVRRVVDRLGDGRAVVLSV
                     TLAAPCTLLAGFAGSGARLAFVVCAQFAFAAGLVVYNVAQVSYRQRTVPAHLLGRVNAT
                     VRFFAWGARPLGVVLGGVLAEFYGTRSAVWAGAAGTALASLWLLCTPLRGMRVLAQPSS
                     ESSVTKEAL"
     gene            20348..21328
                     /locus_tag="Y19_RS0130240"
     CDS             20348..21328
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF020032.4"
                     /locus_tag="Y19_RS0130240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017241273.1"
                     /sec_met_domain="RimK (E-value: 2.5e-11, bitscore: 37.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDHFTDPSTPPRLVWITSPDNYDPRVQERLRREGSERVDMLRAA
                     GFDVRIAHSCDIVPVWNGSPRLLWQKEDLLAEYAGFLVTSWSWDPAIARHLEAITRTIR
                     ASDCPLLTDGTLDPEVLGLDKLAMYHHAAALGAPVLPTVSVPFGRYARRALDAVHTELP
                     DGPYVVKPRSMAMGFGVLKADTTQHLSSAIDLLTPGGLGCLIQPHVPNDGDVRVYVHEG
                     KVIAALLREPDDEAYLANVSQGGSGSGYEPPAEVVELSERLARSLESDYLCVDWLVTGN
                     GYVFNEWMTVSAAYEDLPDRDRRRVADALVRYIRHRLDAGAPRPR"
     gene            21577..22788
                     /locus_tag="Y19_RS0130245"
     CDS             21577..22788
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031385.1"
                     /locus_tag="Y19_RS0130245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_017241274.1"
                     /transl_table=11
                     /translation="MPLALIALAVGAFGIGTTEFVIMGLLPGIAADYGVTIPTAGLLVT
                     GYALGVVIGAPVLTVLGNKVSRKRMLMVLMGLFVLGNVVSALAPSFGVMLAGRVVASLA
                     HGSFFGIGSVVAAGLVAPDKKAGAIATMFTGLTIANIVGVPLGTFIGQAVGWRTTFAVV
                     AALGVAGLLGIARLVPAMPRPEGARLRGELTAFRNPQVLLAMAMTVLGFGGVFAAITYI
                     APMTTEVTGYSEGAVTWLLVLFGVGMFLGNLLGGRYADRALMPLLYATLGGLAVVLALF
                     PVLAHDKVLAAVAILLVGALGFATVPPLQKRVLDQAHGAPTLASAVNIGAFNLGNALAA
                     WLGGLVIAAGFGYTSPNWVGAVLAAAALGLAFWSAALERRTPAAPTADAGAADAAAVRT
                     PVLH"
     gene            22851..23273
                     /locus_tag="Y19_RS0130250"
     CDS             22851..23273
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975016.1"
                     /locus_tag="Y19_RS0130250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="heme-binding protein"
                     /protein_id="WP_017241275.1"
                     /transl_table=11
                     /translation="MSTTTLTPLTTADAETLVSAARNAAEAAGVTVSVTVLDAGGHLLA
                     FRRDDRAVLISGETSTRKAYTALQLDAPTADLVDLVKPDGPFHTLTTALDRPLLFIAGG
                     VPVHRDGRLVGAIGVGGGAPDQDDSFARAALAELSR"
     gene            23327..24157
                     /locus_tag="Y19_RS0130255"
     CDS             23327..24157
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180793.1"
                     /locus_tag="Y19_RS0130255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_017241276.1"
                     /transl_table=11
                     /translation="MAPSTVPTVTLNNGVEIPQLGFGVFQVPYDETAAAVTAALETGYR
                     SIDTAAVYGNETGVGRALAASGLPRDELFVTTKLWNADQGYDATLRAFDASLAKLGLDH
                     VDLYLIHWPTPARDLYRESWRALERLAGEGRVRAAGVSNFQPGHLRRLTEDATLTPAVN
                     QIELHPGLQQAELRAFHAEHGIVTEAWSPLAQGAVLGERAITDLAARHGKSPAQIVLRW
                     HLQLGNVVIPKSVTPARIRENFDVFDFALTDEEMRTVSALDRGMRTGPHPDELG"
     misc_feature    complement(24335..24351)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.11"
                     /tool="antismash"
     misc_feature    complement(24368..24382)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.69"
                     /tool="antismash"
     misc_feature    24375..24389
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.84"
                     /tool="antismash"
     misc_feature    24564..24579
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
ORIGIN
        1 ttctcggggc gccagcggta gccccagccg ccccactggc ggggggtgac gctcggggcg
       61 aagtcggcgc cgacgatgtg ggacaggagg atgcgccggc gcggcaggcc gatgtgcccg
      121 cagcggacct ccatggcgag gtcgtcgacc ttcacggcca cgtggacgaa ggcgagggtg
      181 ccgaagagga cgagcagccc ggccgcaaca cagccgatca ccgccatgag gagcggtgcg
      241 acgccggagg tccagggcga ttcgacggcc agggtgatgc cgagggccat gcaggcggcg
      301 ccgcccgcgg ccgcgagcca ctggagtcgg ttggtggcgc ggccggtcca gacgacgggc
      361 gacccgtcgt cggcctgccg gggccggtgg tgctccctca tacagggaga gtacccagct
      421 tcgccggaca cagcgcgtcg gagcggggtc gtccgctcac gctcagtgag cgggggcggt
      481 cgcggcgagg agtcggccct cggcgtaggt gagggcggtg ccggggagct gtccgggccg
      541 gccgctgagc aggacggaga gggtgccggt ggggtccgcg tcgggtgcgg gctcggcgcc
      601 gatgcggcgc agcgcctggg cggcgacggc gtcggcggag ccgtggaaga cgagcggcgg
      661 cagtccgggc aggcggcggg ccgccagggc ggcgaggacg cgctcctcga ccagttcgta
      721 gtgggtgcag ccgaggacga cggcgcggac gtcggtgggg gtgaggtcgg cggcggcggc
      781 gacggcgcgg tccacggcgt cctggtcggc gtgctccacg gcgtcggcga ggccggggca
      841 gggcacctcg gtgacgtcgg cgccgtcggc gaagtcgcgg atcagtccgc gctggtaggc
      901 gctgccggtg gtggccgggg tggcccagat ggcgaccttg ccgccgccgg tggccgcggg
      961 cttgatcgcg gggacggtgc cgatgaccgg gatgtggggt tcgagggcgg cgcgcagggc
     1021 gggcagggcg tgcacggtgg ccgtgttgca ggccacgatc agcgcctgcg gccggtgctc
     1081 ggcggcggcg agggcgacgg cgagcgcgcg ctccgtgagg tcctcgggcg tacgcgggcc
     1141 ccacggcatg ccgtcggggt cgttggagag gagcagatcc gcgtccggcc ggagtctgcg
     1201 taccgcggtc gccgccggga gcaggccgat tccggagtcc atgagcgcga tcttcacccg
     1261 gtcaccctag ccgatgagca ccgtccaccc ctcgatctgg ggcagactgc cgcgaatgag
     1321 caccctcgcc tggttcgcga tcggttccct cgccgtctgg gtctggctgc tgctgggcca
     1381 gggcttcttc tggcgtacgg accagcggct tccccccacg gccgcgcggc ttgcgacggg
     1441 cgggcggctt cccccgacgg ctccaccgct tccggcggcg ggcggacggg agcctgcgtc
     1501 cgcccgtcgc cgggacgcgg acggctcccc cggcgccggg ccgccggagc ggtggccgcg
     1561 ggtggccgtc gtggtcccgg cgcgggacga ggcggcggtg ctgccgctga gcctgccgtc
     1621 gctgctcgcg caggactatc cgggccgggc cgaggtcttc ctcgtcgacg acgggagtac
     1681 ggacggcacg gggcgtctcg cgggcgagct ggccggccgg ctcggcggcc ttcccctcac
     1741 ggtcgtctcc cccggggagc cggagcccgg gtggaccggg aagctgtggg cgctgcggca
     1801 cggcatggcc ctggcacgcg cgcgtgagcc cgcgccggag ttcctgctcc tgacggacgc
     1861 ggacatcgcc catgatccgc ggagtctgcg gctgctcgcg tccgcggcgg tggagcacga
     1921 tctggacctg gtgtcgcaga tggcccggct ccaggtcgtg agcgtgtggg agcgcctcgt
     1981 cgtgccggcg ttcgtctact tcttcgccca gctctacccc ttccgctgga tcaaccgcgc
     2041 ccggccgctg gcgacggcgg ccgcgggcgg ctgcgtgctg ctgcggacgg agaccgcggt
     2101 cgcggcggcc gttccggatt cgatccggcg ggcggtgatc gacgacgtgt cgctggcgcg
     2161 cgcggtacgg cgcgcgggcg gcaggatctg gctgggcctc gcggaccacg tcgacagcgt
     2221 ccgcccgtac cccgggctgg gcgagctgtg gcggatggtg tcgcggagcg cgtacacgca
     2281 gctgcggaac agtccgctgc tcctcgcggg cacggtggcg gggctcgtcg tggtctacgt
     2341 ggtgccgccg gtggccctgc tcgcgggggc ggcggccggg gacggcgcgg ccgcctgggc
     2401 cggcggcgtg gcgtgggcgg tgatgacggg gacgtacctc ccgatgctcc gctactaccg
     2461 gcagccgcgc ccttcaccgc cgtcctctac ctgctgatga ccgtggactc cgccgtgcgg
     2521 cactaccggg gccggggcgc ggcgtggaag gggcgcacgt acagcgccga ccgcgtctcc
     2581 cggcaagagg ggtagcgccc ttcttcggcg aaccgccccc gccccacgga ccgcgaccgc
     2641 gcgtgtccgt ggggcgttcg cgcgggtcct cagccggcgc tggggtcctc gtcggcgacc
     2701 gaaaggaccg cgtagtcgta catcccgtag gccggggaca tcgtgacgtt ggccgcccgc
     2761 gggcccctga acacgaccga cttcacgtac atgtaggggc acatgacggc ctcgtccatg
     2821 gcggcgcggt ccacggcggc ccagatccgg gcgcgctcct tgtcgtcgcg cgtcgccgcc
     2881 ccggtgtcga ggagggcgtc gatctgcggt gaggccagct ctccgaggtt ctggttcccc
     2941 gtctccttga tcgcccgcga gtcggcgatc tgctggagga agccgtagcc gtcggggaag
     3001 tcggcggccc agccgaacat cacgatcccg atcccgtgct cccgcacgta cgcgggaacg
     3061 cctgccgcct tggtgaagta gtcaccggag gtgaacggaa ccacctcggc ctggatgccg
     3121 acgcgcgcca gtccgcggga gagggcgagc gcggcgttcc actccttcct gcggtcctcc
     3181 cgggcggcga tccgggtggt gaagccgtcc gggaggccgg ccagggcgag ctcgcggcgg
     3241 gccgcctcca ggtcgccggt gccctccggg ccgaccgggt agcggtcgaa ggggtcgtac
     3301 cccaccacgg acgcgggcag cagggtggtg gcgatctcgc cggcggggtc gcccccgtag
     3361 gcggcgagca tcgccgcctt gtcggtggcg tactgcacgg cgcgccgggc gtgcaggctc
     3421 gtcagcgggc cgacgttctg gttgaggcag tagagccaga cgaatcccgt gcgcggattg
     3481 tccacgtgct gccggagctc cggatcggcc agcagccgct cctgggtctc gggctgcacc
     3541 ccgacgccgg cgaggtcgat gtccgcctcg ccgtcgacca ggatgcggtc gacctccgga
     3601 ccgctcacgc cgagccggac cgtgatccgg tccggccggg ccgtccgtac gggatcggtc
     3661 tcggccgccc agtgcgggtt gcggtcgagc gtgagttcgg cgcccggcgt gtaggtgtcg
     3721 atgcggtacg ggcccgagga cagcgggcgg cggtggtact cggggaaggt gtcgtggtcg
     3781 cgcggcaccg ggatggtggt gggcagcgcg gcgaggtagt cgaaggccgc gaagggccgg
     3841 cgcaggcgga agacgagggt gcggtcgtcc ggggtctcga tgccctccgg gcccgtgagg
     3901 tactggcgga agtacgcggg cccgccgcgg gtgaccgtcg cgtcgtagac ctcttcgggg
     3961 aacgcggccc gcagcaccgc gtacttcacg tcctgggacg tgacgggcgt gccgtcctcg
     4021 aaccggactc cctcgcgcag ccggtaggtc caggtgcgcg agtcctcgga tgcctggccg
     4081 agtgcctccg ccaggtccgg tacgaggctc ggggcaccct ccgcgtcggt cgtgtagccg
     4141 acgagcggcc gcccgatgag ccggatgaag ttccaggtgt acgcgtagta cgtgtcggcg
     4201 gggtcgaggg agtcgaagtc gtcggtgcgg acgtaccgga gcgtcccgcc ccggtggtcg
     4261 gacgggttca cggtgccgcg tgcttcagcg ttcagtgcca cgggtgttcc cagcgcctct
     4321 ctcgttgtgc ggatggtgcg gacggctcgt gcgtccggcg acggcggtcg ggtgaccgcg
     4381 cgtcaggaca ggccggatgt cagggggcgc ggcaggtcgc tccccgtgcg cgccggcgaa
     4441 cggcgggcgc tcagttccca catgccgcgg gtgccggcgc gggtgaaccc gaagccggtg
     4501 ttgatgcgga tcatgtgcgt gttgtccgac gcgttccagg tgtccacgac ggtgagccgc
     4561 ggctcggcgg cccggcacgc ggccaggttg tgcgccttca ccagcagtcc cagaccctgc
     4621 ccccggtagg cggggtcgac cacggtgacg gcctggagcg cgttgtccgg gttggcccgc
     4681 gtcatggaca gcgccgtcca ggcggccatc cgccccgtac gggcgtcgac gacgccgcac
     4741 tggtaggcgc gccggccgcg ggcgatgcgc atgcgctcga agtcacggat ccgggacacc
     4801 gcgttcggct ggggttccca ggaggcctgt ccggcggggg cgtcggcgga gagggtggcc
     4861 tccagccggg cggcctgcgt gaccagttcc tcgggaaccg tcgatcccca gaagcgcagt
     4921 cgcaggtgtt ccgggggcgg ggtggggcgg ggcgcgtcgt ccacacggag ccggaggtgt
     4981 tcgtagcgca ccagggcccg ggccctcagc cgggcggcga agcggtgccc gggggtcgcc
     5041 gcggggtccc ccggtccggc gtccgcgacc agcaggacgc gtgagcggcg gcggcgggcg
     5101 gcgcggtccc gggagaattc cgtgatccgc ttccccaccc cctgccggcg gaaggcggga
     5161 tgcacgagga ggacgctcgc ggtgacggcg tcggagttct cctccagcgg gaactccagg
     5221 cgcacggagg cgacgcaccg cccgcccgcg ctgtaggccg cccactcctc gatctcggtg
     5281 gccggaggcg cgacggtgag ggagccctcc aggtcggcgg ggcagggccg gggcaggtgg
     5341 gggacgtcgg cggcgtggcc ggccaggcgc aggtcgtaca cgtcaccgac gacgtcccgg
     5401 tcgccggggt cgacggcggt gaggaagacc gtcaccgagc cagccccatc gcctggatgt
     5461 cgtacagtcc gaacgcgggg tgcacgtaca cgtcggtgac gtcggggtgc cggtagtgca
     5521 gcgtgcggtc gtgggcgatc gggaggatga cggcccgttc catgaccgtc tcctcgaccc
     5581 gctgccagag ccgctgccgg gcctcggggt cgtcgagggc ctgggcctcg tcgacgaggc
     5641 gccggacgac ggggtcgtcg agctcggcga agttgaagtt gccgccgccg ggcttgatct
     5701 gccgtccgtc gaccagcggg gccaggaagc cgtactcggt ggggtagtcg gccccccagt
     5761 cggacactcc gaggccgagg ccgagcgccc gcaccgtgtc ggggtgaccc aggccggaac
     5821 ggtagtacga ggcggtgtcc aggacttcga cgtgcacgcg gatgccgacc cgggcgacgg
     5881 cgtccgcgag ggtccgcgcg accagctcga acttgcccgg ctgggtggcg atcctggtct
     5941 cgaagccgtc gggcaggccc gcggcctcca gttcggcgcg ggcggccttc aggtcgccgg
     6001 tgaggtccgt gccggaggga tagcggtcat ggccggtgtg ggacggcagg gtgggcggga
     6061 tcaggctggt ggcgagcgat ccgccgactc cgtcaccgcc ccgcgcctcc aggagcgcgg
     6121 ccttgtccgc cgcgtagaac acggcgcgcc gcgcgtggac gttgtcgaag gggggcacgc
     6181 acgtctgcac ggtgatgtat tggaggaagc cggtggcggg gttgtcggac cgggcccgca
     6241 gggcggggtc ggcgaggatc acgtcgcgcg ccgagtgctg gatgccgcgg ccctcgacgt
     6301 cgatgtggaa ctcgccggcc atgaggcggc ggtccagctc gttgacgtcc acgccgaagg
     6361 tgacggtcat gtcgtccggc agggcggagc ggagggggtc ggtggcgcgg tcccacatcg
     6421 ggttgcggac gaggtggagg gagtgtcccg cgcggtagct gccgatgcgg tacggcccgg
     6481 agcacaccgg tgccttctcg tagtcctcgc gggtgtcgtg gtgggcggcg acgggggccg
     6541 tgttgggctg cgccatcagg aagtcgaagt ccgcgaaggg gcgcttgagg cggaagcgga
     6601 gggtgtggtc gtcggggcat tcgacggccc ggcagctctg cccgccgtag ggcccccggt
     6661 agtcgccgtg gtcgagcagg tcgagcaggt aggtgggacc gccggggagg acgtcctgcg
     6721 cgaagatccg ttccacggcg tgggcgacgt cccgggcgcg gatcacctcg ccggtctcga
     6781 acctgacgcc gtcgcgtatc cggtacgtcc acgtcaggcc ggagtccgag acctcgccgg
     6841 gaccggtcgc caggtccggc accaccgtgg gggtggccgg gtcggtgccg aaggccatga
     6901 gcgtgcggtg catggtccgc tgcagcagcc acgaccacac gtagtacgta cgggccgggt
     6961 cgagcgagtc gacgtcggcc gaggccacca tggccagcgt cccccctggc gagccgccgg
     7021 ggttcgccac gctcttgact gctccgttcc agccggacat cagccgatct ccttcacgta
     7081 caggtactgc gcggacaggg agcacccgcg ggacaccttg gcgtccgtgg aaccgatgcc
     7141 gtagtggacc gtcttgacgc cgtgtcgcgg ggcgtggtcg gcgagcgtgt aatagagcag
     7201 ctcgtagtac agcggcagct tgcccacggc ctcgtagtcg aagccggcgc ggtgggcgaa
     7261 ccagctgtcg ccgtgggcga ggaccaggcc gaagccgacg atgcttccgt cgagcacggc
     7321 cttcgccacg agcgcgcggt cgccgaggcg ttcggcggcg gccgtcagga cggcctcgga
     7381 gcgcttgggg tcccagctcg tcatgccgta cttggcgaac agccgggtct ccagggcgcc
     7441 gagccgcggg atgtcggcgg ggtcgagggg ggcgagggtg atccgtacgt ccgaggcctc
     7501 gatgtggcgc cgctcggagc ggacgcggcg cgagcgccgg gcggggagcg ccagggcgta
     7561 gtccatgaag ccctcgccgg gcagggtgag ggaggcgaac tggccggact cgtgggcgag
     7621 gtagccgcgc tcgcggagca cggcgcgctg gacgccgtcg gacgcgtcca cgtacgggag
     7681 gcagaccgac cggcacccct cggcggccgc gacgcgctcg gcctcctcca ggatccggtg
     7741 cgccgtctcc ggtccggcgc cggggcccag catgaggcgg gtccggccca ggtgccggcc
     7801 gccgcccatc atcgacggca tgaggcgctc catgtcgccg aacccggcga ggacctccgc
     7861 ggcgccgtcc atgccctcgt cggcgcagtg ccggaccagc aggtcggtgc ggcccagcga
     7921 ccacggggag tcgagggtgg cccgcaccat cggcagggcc gcctgcaacc cgtcgtccgt
     7981 ccgggcggtg agatagccca tccacgctcc ggcggaatcc tgcaggacgc gcatccagtc
     8041 ggggctgagg aagaagtcct ccgcccccac gagcgcgttc cagccggcct cacgcgcgtc
     8101 ctcgggcgtc tgccattggt tgatcaccac tcgactggtc acggggccga tcctctgtcg
     8161 agtcggtctc tgcccgctct cgacccactc cctgatagcg gcttgagaga accacgagag
     8221 agcgccgccg cagggtgtgt cctgatcccg tcatcccgtg aacaggagaa ccgttccatg
     8281 tcccgtgtat ccaccggccc cagtgagcag ccgaccaccg cgcacgccct gctcaagcgc
     8341 ctgcgcgagc acggagtaga gaaggtgttc ggcgtcgtcg gccgcgaagc cgcctcgatc
     8401 ctgttcgacg agcaggacgg catcgagttc gtcctgaccc gccacgagtt caccgccggc
     8461 gtcgccgccg acgtgctggc ccgcatcacc ggccgcccgc aggcctgctg ggccacgctg
     8521 ggccccggca tgaccaacct ggccaccggc atggcgacca gcgccctcga ccgctcgccg
     8581 gtcatcgcga tggcggccca gtcggagtcg cacgacatct tcccgaacga cacgcaccag
     8641 tgcctcgacc tggtcaagat cgccgagccg atctcgaagt acgccgtcga gctggagcgc
     8701 ccgcacgaga tcaccgacct cgtcgactcg gccgtctcgg ccgcgatgac ggagccggtc
     8761 ggcccgtcct tcatcagcct cccggtcgac ctgctgggtt cctccgaggg catcgacctc
     8821 gacaaggacc acggtccggc gctcaccccc gagaagccga tcacggcgat ccagcccggc
     8881 tgggagctgc gcgcggacca ggccgtcgcc ctcgtccgcg aggccgccca ccccgtgttc
     8941 gtcgtcggtg ccgccgcgat ccgcgccgga gcggtccccg cgatccgcgc gctcgccgag
     9001 cgcctgaaca tccccgtgat cacgacgtac atcgccaagg gcgtcctgcc gcacaagcac
     9061 gagctgaact acggcgccgt caccggctac atggacggca tcctgtcgtt cccggccctg
     9121 gagtccctgt tcggcccggc cgacgtcatc ctcaccctgg gctacgacta cgccgaggac
     9181 ctgcgcccct cgatgtggga gcggggcggc gagaagaaga ccgtccgcgt ctccccgacc
     9241 gccaacccgg tgccgcggat ctaccgcccg acggtggacg tcgtcacgga cgtgctcgcc
     9301 ttcgtcaacc acctggacgc cggcaccgcg gacgtcgagg cgaaggaccg ccacgagatc
     9361 tcggccgtgc gggagcggat cgccgagctg ctgtccgacc ccgagtcgta cgacgacggc
     9421 atgcgcgtcc accaggtcat cgactgcatg aactccgtca tgggcgagac cgccgaggac
     9481 ggcgagggca cgatcgtctc ggacatcggc ttcttccgtc actacggtgt gctgttcgcc
     9541 cgcgccgacc agccgtacgg cttcctcacc tcggccggct gctccagctt cggctacggc
     9601 atccccgccg ccatcggcgc ccagatggcc cgccccggcc agccgacgtt cctgatcgcc
     9661 ggcgacggcg gtttccactc caacagcgcc gacctggaga ccatcgcgcg gctcaacctg
     9721 ccgatcgtca cggtcgtcgt caacaacgac accaacggtc tgatcgagct gtaccagaac
     9781 atcggtcacc accgcagcca cgacccggcg atcaagttca ccggcgtgga cttcgtgcag
     9841 ctggccgcgg ccaacggcgt cgagggtgcc cgggcgacga cgcgcgagga gctgctcgcc
     9901 gcgctgcgca agggtgtcga gctgggccgc ccgtacctga tcgaggtgcc ggtgaactac
     9961 gagttcaccg cgggtggctt cggagcgctg aagatctgac atgacgcaga ccgaccttcc
    10021 cgcagcattc ggctttctgg cctccgccca caccggcggg ggctcgatcc ccgcggcagt
    10081 gttcgccacg cgcggccggc acacccggct gtccgagcgg ctgcgcgcgc tgagcgtgga
    10141 cgcagtcctg gtccatcccg atgccggtcc gtccggtgcg cacgcctccg acgcggacac
    10201 cctggtgttg ttcgccgggg agatctacaa ccgtgacgag atcgacgaca ccctggactc
    10261 accggcgaac gcctcggacg ccgagcgggt ctccggtctg ttcgagaagt acgacctcca
    10321 cgcgttccgg ctgatcaacg gccggtacgc ggccctgctg gtgacgggca cccgcgtact
    10381 cgcggcgacg gaccacgccg gttcggtccc gctgtacgta cgccccgacc cggggcacgt
    10441 cctggccgcc accgaggtga agggactggc ggcggccggg gcggcggtcc gcggcgcccc
    10501 ggtcgcgggg gcccgccgcg tccggcggac tcccggggtc caccaggttc ccgccggggc
    10561 ggtgctcgac atccgcgtgg acaccggtga cgcgacggtg caccgcacct gggtgccgcc
    10621 cgtgcaccgg ctcctgacgg gggagaccga ggccctcaac aacgtgcgcg ccgcgctgga
    10681 gagggccgtg gtccggcgtc ttcccgacgg tggcaggccg ctcgtggtcc tgtccggcgg
    10741 gatcgactcc tccgcggtgg ccgcgctgtc cgccagcgtg gccaccgcgg ggatggacac
    10801 cctgtcgatg ggcacggacg tctcggacga gttcccgcag gcccgggtgg tcgcggagca
    10861 cctggcctcg cggcaccggg agctggtcgt cgactcacgg gacctgctgg ccctgctccc
    10921 gcacaccgtg tacgccgccg agtcgctcga ccccgcggtc atcgagtacc tgctgccgct
    10981 caccgcgctg taccgccgca tcgacggtcc gccgcggcgc atcctcaccg ggtacggggc
    11041 cgacattccc ctgggcggca tgcaccggga ggaccggctg ccgaacctgg acaccgcggt
    11101 ggccttcgac atggacacct tcgacgggct gaacgagatg agcccggtgc tgtcggcggt
    11161 ggccggccac tggtccaccc atccctactg ggaccgcgag gtcctggagc tgctgaccgt
    11221 cctggaggcc ggtctgaagc gcaggtacgg gcgggacaag tgggtgctgc gcgccgccat
    11281 gtccgacctg ttgcccgccg agaccgtcgc ccgccccaag ctgggtgtgc acgaggggtc
    11341 cgggacgacc gcgtccttct cgctgctgat ccgtcaggcc ggcgcggcgg aggacgacgt
    11401 ggcggccgtc aaggcgcggg tcgtccagga actgttcgac ctgaccgtgg tgggcggtgt
    11461 cgacccggac gagatcgtgg tcgaggagat catcgggaag atcgtggccg agggcaggcg
    11521 atgaccacat acgaggggtt ccagggcaag cggctcgccg tcgtcgagtc gatgctgcac
    11581 gacgcgttct actccggcat ccaccgcgcg cgggacttcg gctgcgaggt gtggctgctg
    11641 gtgcagggcg aggagtggta caccggcggc ggtccgttgg ccgagcatcc gctgggcaag
    11701 gtcgaccgcg tgctgcacgt cgacacgcac gactggcgtg ccgtggccga cgtcctcacc
    11761 gacgacgacg ggaagcccct ggtggacggg gtgctgtcgt tctccgacta ccacacggag
    11821 gcgaccgccc gcgcggccga ggccctgggg ctgccctccc aggggctgga ggcggtccgc
    11881 gccgcgaacc acaagcacct gctgcggtcc gcgctgggcg aggacccggc caatgtgcgg
    11941 tggcggctgg tcacctgcgc cgatgaactg gacgaggcga tctcccacgt cgggctgccg
    12001 ctgatcgcga aaccgccgtc cgaggccatc tcctacgggg tccgcaagtg cgggacccgg
    12061 gcggaggcgg tcgacgcgtg gcgggagctg tcgggtatcc ggcagtccct gagggggcag
    12121 ccgcgtcccg gctacgtgct cctcgaggag ttcgtgcggg gcaccgagat cagcgtcgag
    12181 tcgatgacgg tggacggcgt cacgcacttc ttcggggcca cctccaagta cctgcacaag
    12241 cagaccatgc tggaggaggc gcactccttc ccgctcgcgc tcgaccccga cgtctgggag
    12301 gcggtccggt cctgcgtgga ccggaccctg cgggccgtcg actaccggca gggcccggcc
    12361 cacaccgagg tgatgctcac cgaggacggg ccgcgcgtcg tcgaggtgaa cccgcggctg
    12421 ccggcccaca tgatctccac gatggtcacc gacgtctgcg ggaccaaccc ccatctggac
    12481 gcgaagctgc tggccctcgg tctggggcac gtaccggacg gaaagcccgg tcagggggtg
    12541 gcggggggcg ccgccgtggt ggtgctgttc ccggaggaga gcggcgagtt cacccacatc
    12601 gacggcatcg acgaggccga acggctcggt gtgtcggtcc gcctccacca cgaaccgggc
    12661 gacctggtcg ccgagcggct ggacaactcg gcctccgtcg gcttcgtgta cgcccacggc
    12721 agcaccgccg aggacgcgct cgacaaggcg cggcgcgcgg cggcacgcat ccacatccac
    12781 acccggagga cggcaccgtg agcggtcaga tcaactcgag cgtctcgccg cggtacgcgc
    12841 agatccccac gttcatgcgg cttccgcacg atccggcgcc ccagggggcc gacgtcgtgg
    12901 tgatcggagc gccttacgac ggcggcacca gctaccgtcc cggcgcgcga ttcggcccgc
    12961 agcagatccg caccgaatcc gggctcatcc acggcgtcgg catcgaccgc ggccccggcg
    13021 tcttcgacct gatcagggtg gtcgacggcg gtgacatcga cctgacgccg ttcaaccagc
    13081 acatcgccat ccagacggcg caggagcgcc tgtccgcgct gctcgcggac aactcggcct
    13141 tcctcatgct cggcggcgac cactcgctca cgctgtcggc gctgcgcgcc gtgcacggcc
    13201 gccacggccc ggtggccgtg ctccacctgg acgcccattc ggacaccaac cccgccatga
    13261 tcggcgggga gttccaccac gggacgccgt tccggcacgg catcgacgaa gggctggtcc
    13321 aggcggacgc catgatccag ctcggcatcc gcgggcacaa tcccaagccc gacagcctcg
    13381 actacgcacg cggtcacggg gtgcgcatcg tcaccgcgga cgagttcgcc gagctgggcg
    13441 tgaaggccac ggcggacctg atcaaggaac ggctcggaga ccgcccggtg tacgtctcgg
    13501 tggacatcga cgtcttcgac cccgcgttcg ccccgggcac gggcactccg gccccgggcg
    13561 gcccgaccag ccgggaggtg ctcgccctgc tgcgcacggt cggtgagctg aacccggtcg
    13621 gattcgacgt gatggaggtg tcgcccgtgt acgaccacgc cggcatcacc agcctgctgg
    13681 ccaccgaagt cagtgcggag ctgctcttcc agtacgcccg cgcgcatcag acgaagaaga
    13741 gggaagagga gagttagcat ggccattctg gacgtgaccg agcaccagga ccttctactg
    13801 tcgctggcgt cgcggcttcc cgccgtgccc cgtcaggacc tgtacggctt cctggacgcg
    13861 gcgcacaagc tcgcgcagga gctgccgtac gaggtcagcg acacgctgga cgccttcaac
    13921 caggtcggca acgaagacgg ctacctgctg ctgcgcgggc ttccggtcga gccggaggac
    13981 gagctgcccg cgacgccgac gagcactccg gcgcccgtcg agcggggccg cctcaacatg
    14041 gaggcgttcc tcgcgatcat cggccggcgc ctcggcctgc acaccgggta cgcggaactg
    14101 cgttcgggga cggtctacca cgacgtgtac ccctcgccgg gcgcgcacca cctgtcgtcg
    14161 gagaccagcg agaccctctt ggagttccac accgagatgg cctaccacac gctgcagccc
    14221 aactacgtgc tgctggcgtg ctccagggcc gaccacgagc gcaaggccca gacgctggtg
    14281 ggctcgatac gcaaggccct ccggctcctg gacgaggaga cgatcgaccg cctctacgac
    14341 gcgaagcagc cctgcgaggt cgacgtggcg ttccgcggcg ggatcgagga cccgggggcc
    14401 atcgccaagg tgaagccgct gtacggtccc caggacgacc cgctcctggg ctacgaccgc
    14461 gagttgctca agccccacga aggcgcggac gccgaggccg tggcgaagct gtcccaggcg
    14521 ctcgacgatg tcaccgaggg tgtcttcctg acgccgggag acctcctgat catcgacaac
    14581 ttccgcacca cgcacgcgcg tacgccgttc tcgccgcgct gggacggcaa ggaccgctgg
    14641 ctgcaccggg tgtacatccg caccaactcc caggggcagc tccccaccgg gggcgagcgc
    14701 gcgggtgacg tcatcacctt caccccgcgc cggtagtccg gcacgcggga cgtcccgtcc
    14761 ggggcaggcc gcgcctgccc cggacgggac tccgccgggt gagtccggcc cctcgctccg
    14821 gccccctcgt tccggcggct cggtcaggag ccgctcggtg cgggcgtcgc gccggcgacc
    14881 gccgtggccg acgtccggtg caggctcagc attccgaggg acagcgccac cgtcatggcc
    14941 gtgagcagcc accacagacc ggcggccgtg tgggtgagga ggaaggccac cagcagcggc
    15001 acgatggcca gcgagaggcc gacgagcacc tggttgaagg cctggtagac cccgatctcg
    15061 cgttcgggag cgagcttcac gagcaggacc gacaaggcct gcgtcgccag gatctccccc
    15121 agcgtgtaga tcgacacccc caggagcagc agcggaagca gcgccgcgaa ggagagcacg
    15181 cccgccaggc cgagcaccgc gagcagggcg gcgtgcagca cgctgccgag cgcgatgacg
    15241 cgcagcggcg cccgcccttc gacgcgcccg gtgatgggga gctggaacag caccatcagc
    15301 acggtgttca cggcgaagac cagccccacc gtccagctgg gggcgcgcag ctcctcgatc
    15361 agatagaccg gaagccccac ctcggtggcg acgatgaccg tgatgagcgc gaagttcgcc
    15421 agggcgagcc gcaggaagag cccgtcgcgc caggggcccc cggttctccc ggtcttctgg
    15481 gagctcgccg gccgcaccgc cgcgaggggc aggtacagca acgccgccag ggcgaagctc
    15541 gccgcgttca gcagacccat cacggtgtaa cccgaaccgt cgtcgacgcc cacgaacacg
    15601 aatcccgcca gcaggccgcc gaagcccatg ccgaggttga acgacacccg cgtcagggcg
    15661 agccagaggc cgacctcctc cgcgggggcg gtcccggcgg cgagcaccgg catggagatc
    15721 tgctcggcgc gctgcgccac cgcggcgacc accgcgaggg cgatgaaggt cgcgatgtgg
    15781 tggatgaaga ggtatcccac gaagacgccc gcccgcacga gcgcggccac gatcagtacg
    15841 gtcctcggtc cccagcgctg caccagccgc cccaccatga agaccgcggg cagggcgatc
    15901 agggtggcgg ccgtgaggcc ggcgcccacg gtggtgagcg agaggtccgt gacggcgacg
    15961 aagaacaaca gctggtacgg gtagaagaat ccggtgccta tcgcgttgac cagggcagcg
    16021 gtgccgaacc agccgacccc ttcgccccgg gggatcgacc gggggcgctt cgcctccccc
    16081 gtgcccgagg ggggcacccg tgcgctgtcg tcggtcttgc gcccggtgct cacagcggat
    16141 ctcctccgga aaacgacgac gcgtgcgcgg acaacgccgc gtgcaggggt ggctgacttg
    16201 ccgccgggcg tggtgttagc ctgctgtcct ggcagagaat cgcctgcgcc agtgtgcgca
    16261 atccgggccc tgggtcgatc cccagctcgt ccgcgagggt ctgtcgcacg ccgtggaaga
    16321 cctccagggc atccgcctgg cggcccgagc ggtagagggc gagcatgagg tcggcgtgga
    16381 gactctctcg taacgggtag ttgtcgacca gctcgaagag ttcgggaatc acctcttcgt
    16441 gccgccccag ctgcagttcg agggacgccc ggtactgcag cgcgacgatg tgttcctcgt
    16501 cgaggcgggt ggaccagctg cgcaggccct gatgggtgag gtccgcgagg gcggggccgc
    16561 gccacaactc gtgtgcggag cgcaccagtc gggccgcttc gtcgagccgg ccgcgccggt
    16621 gcatggtgcg ggcctcggcg accttcgccc ggtagctcgc cacgtcgacc gagcacacct
    16681 cgccgttcag ccggtatccg gtggcacacg actggacgac gtccgccggg gctccggcgt
    16741 tgatgagggt cgtccggagc atccagatgc cggtctgcac ctgccccatg acggttctcg
    16801 ggggcttgtc gaaccacacg gacttgatca gatggccggc ggcgacgacg cgtcccgcct
    16861 gaagcgccag cgcggccagg atccccctct gccggtggcc gggcacggtc acgagatccg
    16921 atccgaccct gacttcgagc ggtcccagca cggcgatgcg cacaggccga gatatgccgt
    16981 ccccgacatc cctgacttct gtcctgtctc tgtcatcggt gaacatcctg agacccttca
    17041 cgtcgtgacg cgcgtcgact gccggtcgaa ctgtgcgtga gaagtagacg gaaggtgcca
    17101 ggggcgtgtc aatggacgcc cggaccagcg cattgattgg ctgatttcat tcagagacga
    17161 tcagcgccct cgcaggactc cggatgccgg acaccgcgca cacgagagcg aacggcctgc
    17221 cgcgggagca ggccggtgcc tgccgacgtc acgaagccgg cgggcgccgc cccctccacg
    17281 cgccgggccg ggccgccatc acgagcgcgt ggcgaacgtg gcgttgccga cgtgatcgcg
    17341 caacgcccgc cgagctgcgc cccgttggac ggccggacac gccggtcacc cgcgtccgag
    17401 acgcgactcg gccaagcggc atatgccagg agatagtgca cttcgctccc gagaacgctc
    17461 gcgggcgcga ggaggccacc ggtccggact acccgccgcc gcggacggca aggcggcgtc
    17521 gcaccttcga ggagacgcgc ggcctgctcc gtacgccctc cgccgagacg ccgaacgtct
    17581 cgacggtggc ccccacggcc gtcgtccgcg cgcctccgcg gctccgcttt cccgccggaa
    17641 cgggcggcgt ggggcgcagc atcgtttgag ccacccgacc tgacgaccta tgtgtcgagg
    17701 cacgaccgga cccatgaggg cgtggcgccc gcctcgccgt acagcccata tgaccggaat
    17761 gcacggctgc gccccataat ctgggtacct ccctggtcgc cgtatgtcac cgatggaggg
    17821 tgcatgttcc tgcagtggct cggggtcgcg ggctgggaaa tccgttgtgg ggatgccagg
    17881 ttgctcttcg atccctatct gagccgcatg cccttccagg cgtccgacgg atcgctcgac
    17941 ccgtccctgc ccctgcggtg ggaccggaag gccgtcgcgt ccgtggccga tcgccacctc
    18001 tcgggccctc ccgatctgat cctgctcagc cacggccact tcgaccacgt ggcggacgta
    18061 ccgcagctgc tggcccatcg cgaatggtcc ggccaccgca tccgcaccct ctgcgacgaa
    18121 acgtcccacc acctcctcgc ggccatgggc accccggacg cccggctggc cgacgtgatc
    18181 cgggtccggg gcggggagca cctccggttc cccggcttca ccgtcgaggt gctgcgcagc
    18241 ctgcacagcc agttcgccga ccacggctac ttcgcgcccg ggacactcgt ccgccggcct
    18301 cgggcaccgc ggacgatcgg ggatctggtc gagggcctga ccctggccta cgtggtctcc
    18361 ttcgacgacg gaccgtcggt gtacctctcc ggcacgagca atctcgccga gcgggaactc
    18421 accggctcgc gaccggatgt cgccctcgtc ggcatgacct cgcacagcgc cgtccaccgg
    18481 tacctggacc gattgcagag cgccctgggc gagccggcgg tcctggtgcc gagtcaccac
    18541 gacgacatgg tctccccgct cctcccggcg gatgaagcgc ggcgggcggg cggcaacccc
    18601 gggcggtcgg ccgcggcact cgcgctggag gaagcggccg cggcccgcgg ggcgcacgga
    18661 acgagggtcg tcgaccccgc tccgctgcga ccgttcgagc cgaccactcc cgtcacagcg
    18721 aagtgaccta tcgtcagatt gctgtggcgg tagccgcctt gcactgaggc ggccccccgt
    18781 gcgctctccc gtcgaatacg tcgacgggtc ggctgagccg tgccatggca cacccccacc
    18841 accgcgacgc gctccgaaca gcctcttgcc gggctcttcg cctgctctcc cttcggcggg
    18901 gccgaggcgg ggcacgtcac tcggcccagg gcggtgacct gcacggacgt ccggagcggc
    18961 gctgcggccg gctcgcggga gcgttgcggg ggacgtgcgg agcgcatagc ttctgcacgt
    19021 cctgaggcct cccgctccac gacgcccgac gcccagacga cttcacggcg gtgccatgca
    19081 gctcagcaag ttccgcggcg gcgtgacccg gacgaccgga acgcccgggc gattcgcggg
    19141 tcttcgccgg ttgttgtggg cgcagtcgct cagccagggc ggtttcgtgg tgctcaacct
    19201 cgcgatgccg ctgctcgccg cgaccggcct gcacgccact ccctttcagg tgagcctggt
    19261 cgccgcctcg cagaccgtcg ccttcctgct gggtcgaccg gatgcgcaaa cgaccgatca
    19321 tgatcgtggc cgacctcgcc cgggcggtgg cgctcggcgc ggtacccgtg ctgtgggcgc
    19381 tggacgcgct caccgtcgcc catctgtgcg cggtggcgtt cgtgatcggt gtcgccaccg
    19441 tgttcttcga tgtcgccgac cagagctatc tgccccatct ggtcggctcc gaagggctgg
    19501 tgacggccaa cgcgcgcctc gtcgtcgtgg accagacggc cgccgtggcc ggtccgggga
    19561 tcgcgggtct gatcgtgcag gcggtcacgg cgcccgcggc cgtgctggtg tcggcggtcg
    19621 cctacgtggg gtcggccctc tgcgtggccc gcatcaagga cccgcgcccc gaaccggtgg
    19681 accggacgcc gcgcgaccgc ctcgggcgtt cgatcctgca gggcatccgg tacctgtggg
    19741 atcacccggt gctccgctgg ctgctggcct gctccacgac catgaccttc ttctggagca
    19801 tgggctacgg catgctcctg gtcctgctgg cacaggacct gggggtgccg gccgtcaccc
    19861 tcgggctgct gttcacggcg ggaggcgtgg gaggcctgtg cgcgaccgcg gtcgtccggc
    19921 gcgtcgtcga tcggctcggt gacggcaggg ccgtcgtcct gagcgtgacc ctggccgctc
    19981 cgtgcaccct gctggcggga ttcgcgggct ccggagcacg gctcgcgttc gtggtctgtg
    20041 cgcagttcgc cttcgcggcg ggactggtcg tctacaacgt cgcccaggtg agctaccgcc
    20101 aacgaaccgt gcccgcacac ctgttggggc gtgtcaacgc gaccgtccgc ttcttcgcct
    20161 ggggcgcgcg gcccctcggc gtggtcctgg gcggcgtcct cgccgagttc tacggcaccc
    20221 ggtccgccgt ctgggcggga gccgccggca cggccctcgc ctcgctctgg ctcctctgta
    20281 ccccccttcg cggcatgcgc gtgctcgcgc agccctcgtc cgagtcgtcc gtcaccaagg
    20341 aagcgctgtg aacgaccact tcaccgaccc ttccacgccg ccgagactgg tgtggatcac
    20401 ctcccccgac aactacgacc cgcgggtgca ggagcggctg cggcgcgagg gctccgagcg
    20461 cgtcgacatg ctgcgcgcgg cgggcttcga cgtacgcatc gcccactcct gcgacatcgt
    20521 ccccgtctgg aacggttcgc cgcgcctcct ctggcagaag gaggacctgc tcgcggagta
    20581 cgcgggattc ctcgtcacct cctggtcctg ggacccggcc atcgcccggc acctcgaggc
    20641 catcacccgg accatccggg cctccgactg ccccctcctc acggacggga ccctggaccc
    20701 cgaggtcctc ggcctcgaca agctggcgat gtaccaccac gcggccgcgc tgggagcccc
    20761 cgtgctgccg accgtgtcgg tccccttcgg gcgctacgcc cggcgcgccc tggacgccgt
    20821 gcacacggaa ctgccggacg gaccgtacgt cgtgaagccg cgctccatgg ccatgggctt
    20881 cggcgtgctc aaggccgaca cgacccagca cctctcctcg gcgatcgacc tgctgacgcc
    20941 cggcggtctc ggctgcctca tccagcccca cgtgcccaat gacggcgacg tgcgggtgta
    21001 cgtgcacgag ggcaaggtca tcgccgccct gctccgcgag ccggacgacg aggcgtacct
    21061 ggccaacgtc agtcagggag gcagcggttc cggctacgag ccgccggccg aggtggtcga
    21121 gctcagcgag cggctggccc gcagcctgga atccgactac ctgtgcgtgg actggctggt
    21181 caccgggaac ggctatgtgt tcaacgagtg gatgaccgtc tccgccgcct acgaggacct
    21241 gcccgaccgg gaccgccggc gcgtcgccga cgcactcgtg cggtacatcc gtcaccgcct
    21301 cgacgcgggg gcgcctcgcc cgcgctgatc tccgtcgcgt ggagcgacgc tccgagcaca
    21361 ctcggcaccg accgaccccg gcatcgcgcc ggggtcggtt tccttttcgc ccacggggtc
    21421 cgcaccggct ccacgacgga gcgcccctct cccccgtacg aaatcaccag caccccgact
    21481 ccgccagtta tctgcgtttg cacttatcgc gcgtctgcaa ttattgtgga agctcgctag
    21541 gagctcactc aagcaaacca aggaagggtc gggctcatgc ctctcgcact catcgccctg
    21601 gccgtcgggg ccttcgggat cggcaccacg gaattcgtga tcatgggcct gctgcccggg
    21661 atcgccgccg actacggcgt caccatcccc acggcgggcc tgctggtcac cggttacgcg
    21721 ctcggcgtcg tcatcggcgc gccggtgctg accgtcctcg gcaacaaggt gagccgcaag
    21781 cggatgctca tggtgctgat gggcctgttc gtgctcggca acgtggtctc ggccctggcc
    21841 ccgtccttcg gggtgatgct ggccgggcgc gtggtcgcct cgctcgcgca cggctcgttc
    21901 ttcggcatcg ggtccgtcgt cgccgccggc ctggtcgcgc cggacaagaa ggccggcgcc
    21961 atcgccacca tgttcaccgg gctgacgatc gccaacatcg tgggcgtgcc gctcggcacc
    22021 ttcatcgggc aggcggtcgg ctggcgcacc accttcgccg tcgtcgccgc gctcggcgtg
    22081 gccggcctgc tcggcatcgc ccgcctcgtg ccggccatgc cccgcccgga gggcgcccgc
    22141 ctgcgcgggg agctgaccgc gttccgcaac ccgcaggtgc tgctcgcgat ggcgatgacc
    22201 gtcctcggct tcggcggggt cttcgccgcc atcacctaca tcgcgccgat gacgaccgag
    22261 gtgaccgggt actccgaagg cgccgtcacc tggctgctgg tcctcttcgg ggtcggcatg
    22321 ttcctcggca acctcctcgg cgggcggtac gccgaccgcg ccctgatgcc cctgctgtac
    22381 gccaccctcg gcgggctcgc ggtcgtcctg gcgctgttcc ccgtgctcgc gcacgacaag
    22441 gtcctcgcgg ccgtcgccat cctgctggtc ggcgcgctcg gcttcgccac cgtgcctccc
    22501 ctgcagaagc gcgtgctgga ccaggcgcac ggcgcgccga cgctggcctc ggccgtcaac
    22561 atcggcgcct tcaacctcgg caacgcgctg gccgcctggc tgggcggact cgtcatcgcc
    22621 gccggcttcg gctacacctc cccgaactgg gtcggcgccg tcctcgccgc cgccgctctg
    22681 ggcctcgcgt tctggtccgc ggccctggag cgccgtaccc ccgccgctcc caccgcggac
    22741 gccggcgccg cggacgccgc cgccgtccgt acccccgtac tccactgaag tcccctcccc
    22801 cggcccctcc ccccgacccg cacccgcacc ccacttccag gagaagcgcc atgagcacga
    22861 ccaccctcac cccgctgacc accgccgacg ccgagacgct ggtctccgcc gcgcggaacg
    22921 cggccgaggc cgccggagtg acggtcagcg tcaccgtcct cgacgccggc ggccacctgc
    22981 tggccttccg ccgggacgac cgggcggtcc tgatatcggg cgagaccagc acccgcaagg
    23041 cgtacaccgc gctccagctc gacgccccga ccgccgacct ggtcgacctg gtcaagcccg
    23101 acggcccctt ccacaccctc accaccgccc tcgaccggcc gctgctcttc atcgccggcg
    23161 gcgtccccgt ccaccgcgac ggccgtctcg tgggcgccat cggggtcggc ggcggcgccc
    23221 ccgaccagga cgactccttc gcccgcgccg cgctcgcgga actgtcccga tgacccccac
    23281 ccctcgcacc gagtccccgc gcaccacgca aggaagcacc cgcaccatgg ctccctccac
    23341 cgtccccacc gtcacgctga acaacggcgt cgagatcccc cagctcggct tcggcgtctt
    23401 ccaggtcccc tacgacgaga cggccgccgc cgtcaccgcc gcgctcgaga ccggctaccg
    23461 cagcatcgac accgccgccg tctacggcaa cgagacgggc gtcggccgcg cgctggccgc
    23521 gtccgggctg ccccgcgacg aactcttcgt caccaccaag ctgtggaacg cggaccaggg
    23581 gtacgacgcc acgctccgcg cgttcgacgc cagcctcgcc aagctcggcc tcgaccacgt
    23641 cgacctgtac ctgatccact ggccgacgcc cgcccgcgac ctgtaccgcg agtcctggcg
    23701 ggccctggag cgcctcgccg gcgaagggcg cgtccgcgcc gccggtgtct ccaacttcca
    23761 gcccggccac ctgcggcgcc tgacggagga cgcgacgctc acccccgccg tcaaccagat
    23821 cgagctgcac cccggtctgc agcaggccga gctgcgcgcc ttccacgccg agcacgggat
    23881 cgtcaccgag gcgtggagcc cgctcgccca gggcgccgtc ctcggcgagc gcgccatcac
    23941 cgacctggcc gcccgccacg gcaagtcccc cgcccagatc gtgctgcgct ggcacctcca
    24001 gctcggcaac gtcgtcatcc ccaagtcggt cactccggcc cgcatccggg agaacttcga
    24061 cgtcttcgac ttcgcactga ccgacgagga gatgcggacc gtgtccgcac tcgaccgcgg
    24121 catgcgcacc ggcccgcacc cggacgagct cggctgaacc gctccgctcc gggcagaaag
    24181 cccggcgcgg ggccccgtgc ccgtcgtcgc ccggcccctt ccgccgatcc ggtaagcacg
    24241 ggcaaagcgg agaagcgggg atcgggcact ctctaatggg agttgggcgc cagggggaca
    24301 gaacacgggg tcgggacgcg gcggcgcagt ggattgccga ttttccgagc aggcattcac
    24361 ctgcgtctaa acacgatttt ctgttactcc ccgaagaagg cggtgtgaag gatgtggatg
    24421 tcgtcccgag aaccggtgaa cggcggcgcc gccctcgttc ggtccggggt cgccgggcgc
    24481 tcggagtccc gtttccggcg aatgccgccg tcacttctcg ttgaccgggg gaccctccgg
    24541 aaaccgcggt gttaacgcgt tctttaacga ggttttggca ggtcaggcgg acaaaaccag
    24601 cgtaaatcgg atgaccgcaa gaagggggct ccccaaccag cacatcgtgg gcttaactta
    24661 tgtgccatga cctccccccg ctccacctat ggaggcggtt actacaccgc gccgtccttc
    24721 ccggacaccc cgatct
//
