LOCUS       NZ_JH941044            19949 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_JH941044
VERSION     NZ_JH941044.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 455737)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 455737)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Draft Genome Sequence of Streptomyces sp. SS, which produces uridyl
            peptide antibiotics sansanmycins
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 455737)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 435788
            Orig. end                         :: 455737
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JH941044.1.
            Bacteria and source DNA available from: Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..19949
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="5"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..19949
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..19949
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:11053](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11053)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    433..448
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.14"
                     /tool="antismash"
     misc_feature    complement(952..967)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(2725..2739)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.26"
                     /tool="antismash"
     gene            3046..4173
                     /locus_tag="Y19_RS0128320"
     CDS             3046..4173
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150790.1"
                     /locus_tag="Y19_RS0128320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkene reductase"
                     /protein_id="WP_017240934.1"
                     /transl_table=11
                     /translation="MITTTAATGTTPAGHEASPLFQPTRLGALRLKNRLVMAPMTRNRA
                     GATGVPEPIMATYYAQRASAGLIIAEATTPNAVGATYPDIPAIHDDTHVAGWRRVTEAV
                     REAGGQMFLQLQHGGRVGHPETSGLHPLAPSPVPLPGTIFTPSGHQETVVPREMTEAQI
                     DATVADFAEAARRAVEAGFAGVEVHSANGYLLHQFLSNATNRRTDGYGGSVAHRIRFTV
                     EVVRAVAEAIGPERVGVRIAPGVTANGMEEDDVEAVYPALLEALRDPGLAYLHVVFADP
                     EQPLFHTLRAAWPGTLIANPALPWPGPLPADGGRGAGERLLAAGADLVSLGRSFLANPD
                     LVARMRAGAALNPVRDAHLMYVGGETGYTDYPTLT"
     gene            complement(4166..5749)
                     /locus_tag="Y19_RS46090"
     CDS             complement(4166..5749)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179802.1"
                     /locus_tag="Y19_RS46090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TerD family protein"
                     /protein_id="WP_051034219.1"
                     /transl_table=11
                     /translation="MTKGGNGYVPTVPLRIAVHGGLDAMALLLTEGGVVRGDGDVVFHG
                     APAHPSGAVRLTAAGGGTAWLDVGLPAVEERITRVLVIGSTETGVLGDVAGLAVEAFAP
                     DGTSVVRYDVTDAAGETAMVIAELYRRAGGWKFRAVGQGYANGLAGLATDHGVDVADPA
                     PGRTAPDAGASPSPTPGASSGPVPAVSPPTGPGPTPVPAPAPAPVPAPPPASGFTPPPA
                     PPPTSGFAPPPAPAPAPGFAPPPPPPAPAPAPGFAPPPAFGPPPTHGFGAPQDPAFAAS
                     KTPGFIPPAAPAAQGFAPPAMPAAGMPGAQVPPAGPAVPGGPGWWSYGPVFEPYTQTGR
                     DNDVITVDGLPPGPVVVQLDVEGDGYTGLSILNWRNKETDNLVNSTEDDFRGRVLATVP
                     KNGTLRMRLEAEGPWRVEVSPLAAARRLTEEEVDFRGPDVLLHTGGVADLAIHYRGVEN
                     LIVNVFELHGHDDHTALPEDDNVVNEIGKRRETVPLPEGPLVVQFEMADGPWRAHLKRV
                     QPPTRQGRFR"
     gene            complement(5917..7317)
                     /locus_tag="Y19_RS0128330"
     CDS             complement(5917..7317)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018531646.1"
                     /locus_tag="Y19_RS0128330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="APC family permease"
                     /protein_id="WP_017240936.1"
                     /transl_table=11
                     /translation="MTDTLSAPHALAPQTGPVPQKLKRSIGVVGGTLLTLSCVTPASTL
                     FVVVPDLFGGVGTFAALTIAIGSLLCIGVAFCYSELGTLIPSAGGEYAIVSTLAGRLAG
                     WLVFVLSLLVVMIVPPVIAMGTADYLAPLVHVPAPLAGAGVMLLATLAGLLDLRANAWI
                     TGVFLVLEVVAAGIVAVFGFAHSERGVGALVHGQVAGEGGTHSLVTGAMVVSGLAIALF
                     ITQGFSTAVYLSEELENPRKSVARTVLATLAISTVVILVPVVAITLGAGDLETLTGGDI
                     SGMIAAWSSSAVGTFISLCVALAIVNAGIVMVIQNSRVLFASARDKAWPEPVNHALSRL
                     GRFGSPWVATLLVGVPGAALCFVDLDTLYGVTGVSVTGMYLLVAVAALFSRRGAHREVA
                     AWRMPLWPAVPVLLIGVLAYVLSMQDTEYLLWTGGITAVATLYWALYLRPRKDTRWLVS
                     VPEDDHHA"
     misc_feature    complement(7506..7526)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.15"
                     /tool="antismash"
     misc_feature    complement(7736..7745)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            7840..8718
                     /locus_tag="Y19_RS40340"
     CDS             7840..8718
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Y19_RS40340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="regulatory protein"
                     /protein_id="WP_017240937.1"
                     /transl_table=11
                     /translation="MPVSRPAPGRPGELIPVSPDAAAAEVVGPLEADLARAAARAQSVR
                     DELHSLMPRYRAARREQGRREGFDVLPDTASASAMPTEESARCREEVFSIQPGGGRAPH
                     RLGDAAERDVAMLRRGVRMRTLYQHSARAGLSTQGYVERLTEAGAEYRTAAELPDRAVV
                     FDRSVAFLPRRADGGTGEGAVLVRDPDVVAYLCRVFEQHWSGAAPFRGAGEAAYKEVGP
                     SLRRTLVGLLAQGAKDEVIARRMGMSLRTCRRHVAELLEERGAESRFQGGALAERAGLT
                     GADVTADVSAG"
     gene            complement(8737..9900)
                     /locus_tag="Y19_RS0128340"
     CDS             complement(8737..9900)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514140.1"
                     /locus_tag="Y19_RS0128340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="oxygenase MpaB family protein"
                     /protein_id="WP_017240938.1"
                     /transl_table=11
                     /translation="MIHTEASMDALRQTGDELADATVATLFERGEVGTFNTLMRYVSTA
                     GSPLPDGLPDVARDYLEATATPPAWVDWGEMEKARLFFIDNNVHISTALSFASMPACYV
                     VPHVAKLLSATHGLEYPSKRMAETGQFTVHLMQPDAFEAGSRFIPAAQKVRLLHASIRH
                     HLKRENRWDTASLGVPICQEDMIGGQMFFSMLVLDSLHRLGIHMSTEGAEAYYYAWRVV
                     GAMLGVDQEAVPESLDEARRFLDLYMVRHMGPSPEGAHLTRQLIDLYEEVVPGTLFDPV
                     VSALIRYLVGDTCADWLDVPRTRWDTVVKAVPHLLGVLESIEDRSPLGAWALDRLGHLT
                     TVLELSSLTRGRVMHYAIPEHLRKDYGVPSGPPRTRRWTPPAATVPS"
     gene            complement(10001..11053)
                     /locus_tag="Y19_RS0128345"
     CDS             complement(10001..11053)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379394.1"
                     /locus_tag="Y19_RS0128345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_017240939.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 5.3e-38, bitscore:
                     125.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAERWDAAAFKARVDEVLRRYAAEEADRLVEVDPALGPVAGQLET
                     AVADGKRLRAAFCHWGWRAVGQPDSEALLRAAASMELVHAAAVVHDDLIDDSPLRHGRP
                     TAHVALRGAVAHHPRVSAGARSLAMLVGDLLMSLAGQLFVTSGLPAAYLGRARPLWAAL
                     ARDLIAGECLEILHTGAAPDTAASLKVIRYKTAKYTVEQPLLIGGALAGAGGRLREGYS
                     AYGLPLGEAFQLRDDLLGLFGDEETTGKADADDVRGRRPTALLAETWRLAGEKDRDRLR
                     ELLGGTDPDGDAPEAVREVMRRLKAPERVEAMITARVDEALRALDELNLPPAPAAALTA
                     LAHSAAVRRH"
     gene            complement(11046..11324)
                     /locus_tag="Y19_RS0128350"
     CDS             complement(11046..11324)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152512.1"
                     /locus_tag="Y19_RS0128350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017240940.1"
                     /transl_table=11
                     /translation="MTRETGSREGLDERVVLVAAGLADLAVEAVGSGLGIVRGLLRRSD
                     AAEVAADAERDLEARGRLVLDRYASPPPAHLEVLARHAIARRAGDGG"
     misc_feature    11504..11520
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.38"
                     /tool="antismash"
     misc_feature    complement(11512..11525)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     misc_feature    complement(11516..11529)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.57"
                     /tool="antismash"
     gene            11581..12462
                     /locus_tag="Y19_RS0128355"
     CDS             11581..12462
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018519072.1"
                     /locus_tag="Y19_RS0128355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine protease"
                     /protein_id="WP_017240941.1"
                     /transl_table=11
                     /translation="MNKPLAGALLALLLAGATAAPAAASTPQETAAQATAPTARTQAPA
                     AQAAAAVDFAGTVALSNCSGSLVRAPGSLPSDPALVLSNGHCLETGFPAAGEVIKDQRS
                     SRSFSLLNSAGTKVATLRASKIAYATMTDTDMSVYQVTKTYAQIQSQYGISPLTLNDAH
                     PVQGTSIKVVSGYWKRIYSCDIDGFAYRLKEGSWTWKDSVRYTSSCNTIGGTSGSPVID
                     TATGKVVAVNNTGNESGESCTVNNPCEVDQNGAVTVRQGINYAQQTYTLVPCIGPGNVI
                     DLNRAGCLLPKP"
     gene            12623..12958
                     /locus_tag="Y19_RS0128360"
     CDS             12623..12958
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048316.1"
                     /locus_tag="Y19_RS0128360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017240942.1"
                     /transl_table=11
                     /translation="MQQTRRPRPFRPSAGETSTRPTALPALVAGSLAAALLLTGCMGQE
                     RVCGSGRYPVKAVGNTDGQDCVADGQEPPEGYVRYPAGMVPEHVGDKWDRHWGTIVVDA
                     EGRPTQP"
     gene            13175..14164
                     /locus_tag="Y19_RS0128365"
     CDS             13175..14164
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468390.1"
                     /locus_tag="Y19_RS0128365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="esterase family protein"
                     /protein_id="WP_017240943.1"
                     /transl_table=11
                     /translation="MSAQHPTRRSILKTAGGLSAAMALGAGGVLGAAAPASAAGDGFGL
                     RIVDRNEADHRMWYYRFQTDAIGWNPGVNVLLPDDYHWSGRRYPVLYLFHGGGTDQDFI
                     TFDREGVRDWTAGKPIIVVMPDGGHAGWYSNPVSSNVGPRNWEHFHIAQLLPWVEANFR
                     TYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASVSAHSGPASLRRDNGLVGHWANASSA
                     ALDLNGGTIYGAPFWDEARVSADNPVQRIESYRHKRVFLVAGTSPDPVNWFDTANETQV
                     LAGQREFRSLLGNAGIPHEWYELPGGHFIRHDMMRRDIDGIIGRLRKA"
     gene            14229..15749
                     /locus_tag="Y19_RS0128370"
     CDS             14229..15749
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182468.1"
                     /locus_tag="Y19_RS0128370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidoglycan DD-metalloendopeptidase family
                     protein"
                     /protein_id="WP_017240944.1"
                     /transl_table=11
                     /translation="MLPGLSRRVLSRVLAAAAALLPVLVAATPATAGPAGATGPVLACP
                     TAGFVSQPFHAGHNGVDIANDVGTPIHAVADGEVTISGYTGDYGQWIRVRHPDGRTSEY
                     GHMSRRDVSVGDRVTAGQQIALMGAEGNSDGPHLHLRIWGDLSYSYGIDPEVYLAEGGV
                     ILPCVPGSGPRPAPLVYPAESGRVVSARSADGRLEVFSAGADGVHHAWQREANRDWSEW
                     EALGGPGDAQLAIAPDADGRLELFAIDGNTFRHRYQLSPSGGWSGWEDFGGGGHDIAAG
                     VNADGRIEVFASGPAGVFHRYQLAPNGGWSAWEATGGGPAGSRIEMEKSPDGRLEVFAL
                     NGSSFQHLYQTAPNGGWSAWGDFGGGGHDLTVDHNADGRIEVFASGPIGVFHKYQTGPT
                     SWSDWEGTGGPADAQLSSERTADGRVEVFAMNGRTAVHAWQTGVNAPYGAWEPFGGGGT
                     EVTATSNADGRIEVFGTNPTGTYHIWQTGFAAWSPWGWVNGTAGPGLD"
     gene            15846..17876
                     /locus_tag="Y19_RS0128375"
     CDS             15846..17876
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018516213.1"
                     /locus_tag="Y19_RS0128375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_017240945.1"
                     /transl_table=11
                     /translation="MLPISRRNLLRGAAGAGALSITGAARAAAAAAGAVPPPRWVGAGP
                     FARVYDPSTAAGPRYLNDHTLIRAQGRWHLFAIVGDAAPPGESPDSTAEISFAHASAPA
                     PYGPWTTHADALTVDPSYFGEEHLWAPHVVEADGRFLMFYAAGGASGAAINLATSTDLF
                     TWTREPSGPLFRGLAARDPMVLRVGGEWVMYYTELSGAGGHHVVACRRSADLVHWSEPG
                     VAFTDASTDATVSVTESPYVVERDGWYYLFIGPRNGYEGTDVLASRDPFRFDLTGAAGH
                     VPGHAVEVFADGEAWYACAAGWFEQGLHLAPLQWRDTPPPWQSPDDPVAGLDVAGRLTV
                     FALDAGDRSMLRRVQLAPDTDTWSEWETFGGPAGAVPVLGRNADGRLEVFSLAPGGVNL
                     HHRVQRPDGGWYGWEEFGGPAGAAPAVARDAEGRLEVFASSPGASSFARRRQRSPGSTA
                     WDAWEPGFGGAAGAPPVVAANADGRLEVFVLAAGGAGLRHRWQESPGGAWTGAWHAFGT
                     AAGAAPRVARDGSGRLTVAAIGPSGVGTFVRRQSVPSGGWDGWQPLFDWSAAAPAFAAN
                     ADGRLEAFSLSPGGARLVHRWQNSPGGAWDPVTEFGEPGVRLAATPSAALDSTGRIHVF
                     AVTPGGLVRTRVQAWPSGGWRPWTAFGDRAVVPVVSGGPAL"
     gene            18386..19807
                     /locus_tag="Y19_RS0128380"
     CDS             18386..19807
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611979.1"
                     /locus_tag="Y19_RS0128380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_017240946.1"
                     /sec_met_domain="Pkinase (E-value: 8.4e-34, bitscore:
                     111.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPPRDAGDTTEHDRADLLPPGYRVGDWAVTELIGAGGWSTVYAA
                     RPVEAARSRPARDRGDDVALKVMPTAGLAPRQARRIVESARREVELGRRAGHPRLIGLR
                     ESFVLSAPDRPAVDGAIVLVMERAAGSLRELLDAGVSGGERGGLIAGICEGLAHLHRSG
                     WVHADLKPENVLLGRDGSVRLSDFGLATELTGTHGYVPPLGTLDYLPPERWRAPLGELG
                     VQVRPSADIWALGVVIHEVFASGASPFPGATPLARGAAVQEYGEGRAPLRMDLAVPPFW
                     RALAADCLAPTHAARAPHTAESLLARIAAHEGTRGARVRGARSRARSAVLAGVLCAGVG
                     ATLWSDAVREDGFADPDRAGAAVDTVRVFNAERGCQDRADRDPQCSLGLAIDPLRPYAA
                     GNVVPTRVWHGDDLTADCRLFDGQPVIDEEDLQSTLWFRVRLPRGSAYPAAWLPAVRTK
                     DRPALPGCPRPATAR"
ORIGIN
        1 ccctgctcgg cggccgcgcg ccgggcccgc tcgtgcagga cgcgggcctc ctcccactcg
       61 ccggcgagca gtgcgagccg gccgaggccg ccgaggcggg cggaggcctc cgcggcgagc
      121 cccaggtctt cggcgagtcg cagcccttcg gtctgccggg cggtggcggc ggcgtagtcg
      181 ccctcgatct cggcgagcgc ggcgaggacg ggaaccgtct gcaactcgcc ccatcggtcg
      241 ccgagttcac ggaacgcctg cgctccgccg acgccttcgg cgcgcgcggt gcgcaggtcg
      301 ccctcggcga acgcggtgtg tgcccgcagc gcccgcgcgg cggcgactcc ccacgggtcg
      361 gcggctgcgg tgaaccgttc gagggcacgg gcgttgacgc gctccgcccc ggccgggtcg
      421 cccgcgtggt acaggccgta cgcgaacagc cagagcgtgc ggccgcggcg tacggggtcg
      481 gcgatctccg cttcggggca gtccgtgtcc ggcacgcgcc caccggtcat catgacgaac
      541 gccccgtgca ggagccgtag ttcggcggag cgttcaccgg aggcgacctt caggacggcg
      601 tcgagcgtac gtcgcgcctc gtgcaggcgg ccccgcgtca gccaccacgg gcacagtgcc
      661 gtggccagcc gctcggcgct cgtggggtcg ccggtgcgca gggcgtggtc gagggccgcg
      721 cgcgtgttgg cggactcggc gtccagccgg gcgagcgcga ggtgctgtcc ggggccgcgc
      781 aggtgggctt cggtgcgctc ggcgaggtcg cggtggtggt ggacgtggcg ggccgccgtg
      841 ctctcccact cccgcgcctc gtggagccgg tcgcgggcgt aggcggcgac cgattcgagc
      901 agccggtagc gcggtccgcc gggggccgcg accgtcatga cgagggagcg gtcgaccagg
      961 cggcccacca ggtcgagtac ctcctcgcgg gcgatgccgt cgcccgcgca caccgtctcc
     1021 gccgcctcca gtgcgcagct tccggcgggg acggacagtc ggcgcagcac cgcccgttcc
     1081 gacgggtcga gcaggtccca gctccagtcg atgaccgccc gcagggtctg ctgccgggcc
     1141 ggcagccccc gctgtcccga cgcgaggagc cggaaccggt cgccgaggcg cgcggccaac
     1201 tcccttactc ctacggctcg tacccgtgtc gcggcgagtt ccagagcgag gggaagcccg
     1261 tcgagtcgtc ggcatatctc cgctatggcg tcccgggccg tcccgtgccc atccccgtac
     1321 ccgtaccctt gcccgtaccc gcactcgtcc cgttccccgc ccccgccccc gtcctcggcc
     1381 tcgggtgcga agccgggcgc cgccgccgcg gcccgttcgg tgaagagccg ggcggcggca
     1441 tcggggccga ggggatcgac cgcgtacacc gcctcgccgg gcagccgcag ggactcccgg
     1501 ctcgtggcga gcacgcgcag ccccggcgcg gtgtgcagga gcgacgcgac cagctcggcg
     1561 gccggttcga tgacgtgctc gcagttgtcg aggacgagca gggcctcgcg ctccctcagc
     1621 gccgcgagca gggtctccga cgggccggcc gcgccgcgtc ccggggacgc ggagtcgcga
     1681 acgccgagcg cttcggcaac cgtccggacg agaccgtcgg tcgccgccgt ctcggcgggc
     1741 agcccgccga actcgacgaa ccacacgccg tcgggcgtcc ggtcgtccgg gtcgtccgcg
     1801 agccgttcgg cgacggccag ggcgagccgg gtcttgccca ccccgcccgg cccggtcagc
     1861 gtcaccagcc gctcgaccgc gaggagccgg ccggcccgtt ccacgtcctc ctcccgcccg
     1921 accagcgccg tcgccggaac gggcaggttc cggcgccgag agccgatgcc ggacggagcg
     1981 gaggcgtacg ggtcccgggc gtacgcctcc ggggcgggcg cggcttccgg cgtcgggcgg
     2041 ggccgctgcg ggctcgtacg gcccgcgtcc gcgtccggcc tccggtccgg ggcaccggcc
     2101 gaggagcgtc cggcggggac ggccccaggg ggctcggcgg acgggtgcag ccccgggtcc
     2161 tgccgcagga tggcctcgta cagggccgcg agtgcggggc tcgggtcgag gcccagttcg
     2221 tcggcgagca gggtgcggag ttcggtgtac gcggcgaccg cctcgccctg ccgtccggcg
     2281 gcgtacaggg cccgcatccg cagggcgcgc agccgctcgc gcagcgggtg gcgggcgacg
     2341 agcccggccg tctcgccgag cagggcgggg tccccgaact ccagccgggc ctcggcctgt
     2401 tcctcgacga cggtgagccg ctcctcggcc aggcgccggg ccgccgggcg tacgaactcc
     2461 tcgtcggcga agtccgcgta ggcgggcccg cgccacagct ccagggcctc cgcgaacagg
     2521 gccgcccggg cgcgcggtgc ggtgaggagg cgggcccggg ccgcgagggc gcggaagtgc
     2581 tccgcgtcga cctcggcctc gccgtcgtcg aggcgcagcc ggtatccggc cggctggtgg
     2641 gagacgcggt cccgtccgat gacgcggcgc agctgggaga ccttggcctg gagcgcgttg
     2701 gccgggttgc ccgggaccgc gtccccccag atgtcgtgca cgaggcggtc cgtcgacacc
     2761 gggcggccct cgtgcgcgag gaggtcggcg aggagcgccc gcaccttggt ctccggcacc
     2821 cgcagcggtg cgccgtcggc gtcccacacc gccaccggac cgagcacccc gaacctcatg
     2881 gcaggaaccc tacacaccca tgatcatccc gcccccggtg gaccgtcagc ggaccgtcag
     2941 cgttctcgaa gcggcgtgcg cgacattcgg ttcagcgggg ctcgccgccc cgaacaggag
     3001 caaggacgag ggagcacgtc gatgagcacg gctacgagca cggcaatgat cacgaccacg
     3061 gccgcgaccg gcaccacccc cgcgggccac gaggcctccc cgctgttcca gccgacccgc
     3121 ctcggcgcgc tgcggctgaa gaaccggctg gtcatggccc cgatgacgcg gaaccgggcg
     3181 ggggcgaccg gcgttccgga gccgatcatg gccacgtact acgcacagcg cgcctcggcc
     3241 gggctgatca tcgcggaggc cacgacgccg aacgcggtgg gtgcgacgta ccccgacatc
     3301 cccgcgatcc acgacgacac gcacgtggcc gggtggcggc gggtgacgga agcggtgcgg
     3361 gaggccggcg ggcagatgtt cctccagttg cagcacggcg ggagggtcgg ccaccccgag
     3421 accagcggcc tccacccgct ggccccgtcg ccggtcccgc tgccgggcac gatcttcacc
     3481 ccctccgggc accaggagac cgtggtgcca cgggagatga cggaggctca gatcgacgcg
     3541 acggtcgccg acttcgccga ggccgcgcgc cgggcggtgg aggccggttt cgccggggtc
     3601 gaggtgcact ccgccaacgg ctatctgctg caccagttcc tgtccaacgc caccaaccgg
     3661 cgcaccgacg gctacggcgg ttccgtcgcg caccgcatcc gcttcaccgt ggaggtcgtc
     3721 cgcgcggtcg ccgaggcgat cggccccgag cgggtcggcg tgcgcatcgc ccccggcgtc
     3781 accgccaacg gcatggagga ggacgacgtc gaggcggtct acccggcgct cctggaggcg
     3841 ctgcgcgatc cgggcctcgc ctatctgcac gtcgtgttcg ccgaccccga gcagccgctg
     3901 ttccacacgc tccgcgcggc ctggccgggc acgctcatcg cgaacccggc cctgccctgg
     3961 cccggccccc tgcccgccga cggcggacgc ggcgccggcg agcgcctcct ggcggccggc
     4021 gcggacctgg tctccctcgg ccgctccttc ctcgccaatc ccgacctggt cgcccggatg
     4081 cgggccggcg cggccctcaa cccggtccgc gacgcccatc tgatgtacgt gggcggcgag
     4141 accggctaca ccgactaccc gacgctcacc tgaagcgccc ctgccgggtc ggcggctgca
     4201 cccgcttgag atgggcccgc cacgggccgt ccgccatctc gaactgcacc acgagcggtc
     4261 cctcgggcag cggaacggtc tcacggcgct tgccgatctc gttgaccacg ttgtcgtcct
     4321 cgggcagggc ggtgtggtcg tcgtgcccgt ggagctcgaa gacgttcacg atgaggttct
     4381 cgacaccccg gtagtggatg gcgaggtccg ccacgccccc cgtgtgcaac agcacgtcgg
     4441 ggccgcggaa gtccacctcc tcctccgtca ggcggcgggc cgccgccagc ggcgacacct
     4501 ccacccgcca cggcccctcc gcctccagcc tcatccgcag ggtcccgttc ttgggcaccg
     4561 tggcgagcac ccgtccccgg aagtcgtcct cggtgctgtt gacgaggttg tccgtctcct
     4621 tgttgcgcca gttgaggatc gagagacccg tgtacccgtc gccctcgacg tcgagctgga
     4681 cgacgaccgg acccggcggg agcccgtcga ccgtgatcac gtcgttgtcc cggccggtct
     4741 gcgtgtacgg ctcgaagacg ggcccgtacg accaccagcc cggcccgccc gggacggcgg
     4801 gccccgcggg cggaacctgc gccccgggca tgcccgccgc gggcatcgcc ggaggcgcga
     4861 agccctgcgc ggccggggcg gccggcggga tgaagcccgg cgtcttcgag gccgcgaagg
     4921 ccgggtcctg cggcgcaccg aagccgtgcg tgggcggcgg cccgaaggcc ggcgggggcg
     4981 cgaatcccgg cgcgggcgcg ggagcgggcg gaggcggcgg gggcgcgaaa ccaggcgcgg
     5041 gagccggagc aggcggaggc gcgaagcccg acgtgggcgg cggggcgggc ggaggcgtga
     5101 agcccgacgc gggcggcggg gcgggcacgg gggccggagc gggagccggt accggcgtgg
     5161 gccccggtcc cgtcgggggc gacaccgccg ggaccgggcc cgaggacgcg cccggcgtcg
     5221 gcgacggcga cgcgcccgcg tcgggcgccg tacggccggg ggccgggtcc gccacgtcca
     5281 cgccgtggtc ggtggcgagg ccggcgaggc cgttcgcgta accctggccc acggcccgga
     5341 acttccagcc gcccgcgcgc cggtacagct ctgcgatcac catcgccgtc tctccggcgg
     5401 cgtccgtcac gtcgtagcgc acgacggacg tgccgtcggg tgcgaaggcc tcgaccgcga
     5461 gaccggcgac gtcgccgagg acaccggtct cggtcgagcc gatcaccagg acgcgggtga
     5521 tccgctcctc gacggccggg aggccgacgt ccagccaggc cgtcccgccg cccgccgccg
     5581 tgagccgtac ggcacccgac gggtgcgcgg gcgcgccgtg gaagacgacg tctccgtccc
     5641 cccggaccac gccgccctcg gtgagcagca acgccatcgc gtccaggccg ccgtgtacgg
     5701 cgatccgcag cggcacggtc ggcacgtagc cgttgccgcc cttggtcatc tcccccacga
     5761 cgtaccggtc cttcccctcg tgttcccacc ctcgtcgttc acggaacgat cttgcagcgg
     5821 cgggcgcgcg cggacaaggc cgcgcgaacg gcgaagcccg ggggccgggg cggtgtcgta
     5881 ccgccccggc ccccgggacc gtgtcgtcgg ggacggtcag gcgtggtggt cgtcctcggg
     5941 aacgctgacc agccagcggg tgtccttgcg cgggcgcagg tagagggccc agtagagcgt
     6001 ggcgaccgcc gtgatgccgc cggtccacag caggtactcg gtgtcctgca tggagaggac
     6061 gtacgccagg acgccgatga gcagcaccgg gacggccggc cacagcggca tgcgccacgc
     6121 ggcgacctcg cggtgcgcgc cccggcggct gaacagcgcc gccaccgcga cgagcaggta
     6181 catgccggtg acggagacgc cggtgacgcc gtagagggtg tcgaggtcga cgaagcacag
     6241 ggcggcgccg gggacgccga cgagcagggt ggcgacccac ggcgagccga accggcccag
     6301 ccgcgacagg gcgtggttga cgggctcggg ccaggccttg tcgcgggcgg aggcgaacag
     6361 gacgcgggag ttctggatga ccatgacgat gccggcgttg acgatggcca gggcgacgca
     6421 gaggctgatg aaggtgccga cggcggagct ggaccaggcg gcgatcatgc cgctgatgtc
     6481 gccgccggtc agggtctcca ggtcgccggc gccgagggtg atggccacga cgggaaccag
     6541 gatcacgacg gtggagatgg ccagggtggc gagcacggtg cgggccacgc tcttgcgcgg
     6601 gttctccagt tcctcggaga ggtagacggc cgtcgagaag ccctgggtga tgaagagggc
     6661 gatggcgagg ccggagacca ccatggcgcc ggtgacgagc gagtgcgtgc cgccctcgcc
     6721 tgcgacctgg ccgtggacga gcgcgccgac gccgcgctcc gagtgggcga agccgaagac
     6781 ggcgacgatg ccggccgcga cgacttcgag gacgaggaag acgccggtga tccaggcgtt
     6841 ggcgcgcagg tcgagcaggc ccgcgagggt ggcgaggagc atcacgccgg cgccggcgag
     6901 cggggccggg acgtggacca ggggcgccag gtagtcggcg gtccccatgg cgatcaccgg
     6961 tggcacgatc atcacgacga gcagcgacag gacgaagaca agccagccgg ccagccggcc
     7021 agcgagggtg gagacgatgg cgtactcgcc gcccgcgctc gggatcaggg tgcccagctc
     7081 ggagtagcag aacgccacgc cgatacagag cagcgagccg atggcgatgg tcagcgcggc
     7141 gaaggtgccg accccgccga acaggtccgg tacgacgacg aacagggtgg aggcgggtgt
     7201 cacgcacgac agcgtgagca gggtgccccc cacgacaccg atggagcgct tgagcttctg
     7261 cggcacgggg ccggtctgcg gggccaacgc gtgcggcgcg ctgagggtgt cggtcatcag
     7321 acggttccga tcgatgagct aggtgtgtgc gagcgggagc ggtatcgcct ccgaggcggc
     7381 cggtgaaagg gtgggtccgt ggctcccggg ctgaatggaa gcgtgggcag aaccgcaggt
     7441 caatggcctg ccggctgcgg aattcgttgc tcctccacgc ccggggggag cctcggggcg
     7501 ccaagaacgc gtcaagacgg cgaaaacgct ccgtgcggga accgcacccc gcccgcccgg
     7561 acttttcccg tgctttaccg ccggtgtccg gccttcggac accccggccg tggagaagcc
     7621 gtacctaccg acgcgtacgg cacccccgcc ctctcgcggc ggagaccggg cagcacgacg
     7681 ggaggaaagc acccgccttc ccggcggaga ccggccacca cgacgggagg ggaccggccg
     7741 ccttcccggc ggagaccggg cagcacgacg ggaggggacc ggccggcgtc ggcggtcccc
     7801 tcccccgggc ggcatggggt gcgccgcccg tttcacgcgg tgccggtcag caggccggcg
     7861 cccggcaggc ccggggagct gatcccggtc agcccggacg ccgccgccgc ggaggtcgtg
     7921 ggcccgctgg aggcggacct cgcgcgggcc gccgcccggg cccagtccgt ccgcgacgag
     7981 ctgcactccc tgatgccgcg ctaccgcgcc gcccggcgcg agcagggccg ccgggagggc
     8041 ttcgacgtgc tgcccgacac ggcctccgcc tccgcgatgc ccaccgagga gtcggcccgc
     8101 tgccgtgagg aggtgttcag catccagccg gggggcggcc gggcgccgca ccgcctcggg
     8161 gacgccgccg agcgggacgt cgcgatgctc cgccggggcg tgcggatgcg gacgctctac
     8221 cagcactcgg cgcgggccgg cctgtcgacc caggggtacg tggagcggct caccgaggcc
     8281 ggcgccgagt accgtaccgc cgccgaactg ccggaccggg ccgtggtctt cgaccgttcc
     8341 gtggccttcc tgccgcgccg tgccgacggc ggcacgggcg agggcgccgt gctcgtccgg
     8401 gaccccgacg tggtggcgta cctctgccgg gtcttcgagc agcactggtc gggtgcggcg
     8461 ccgttccggg gcgccggcga ggccgcgtac aaggaggtcg ggcccagtct gcggcgcacg
     8521 ctggtggggc tcctggcgca gggcgcgaag gacgaggtga tcgcccggcg catggggatg
     8581 tccctgcgca cctgccgccg tcacgtcgcc gaactcctgg aggagcgggg ggcggagagc
     8641 cgtttccagg gcggggcgct cgcggagcgc gccgggctca ccggggcgga cgtcacggcg
     8701 gacgtctccg ccggctgacg cccgctccct cccgtctcag gaggggacgg tggcggccgg
     8761 cggtgtccag cggcgggtgc ggggcgggcc ggacggaacg ccgtagtcct tcctgaggtg
     8821 ttcggggatg gcgtagtgca tgacgcggcc gcgggtgagg gaggacagtt cgaggacggt
     8881 ggtgaggtgg ccgaggcggt ccagggccca ggcgccgagc ggagagcggt cctcgatgct
     8941 ctccaggacg ccgaggaggt gggggacggc cttgaccacg gtgtcccagc gggtgcgggg
     9001 cacgtccagc cagtcggcgc aggtgtcgcc gacgaggtag cggatgaggg ccgagacgac
     9061 cgggtcgaag agggtgccgg gcacgacctc ctcgtacagg tcgatcagct gccgggtcag
     9121 gtgggctccc tccggcgacg gccccatgtg gcggaccatg tacaggtcga ggaaccggcg
     9181 tgcctcgtcg agggactcgg gtacggcctc ctggtcgact ccgagcatcg cgccgacgac
     9241 gcgccaggcg tagtagtacg cctccgcccc ctccgtcgac atgtggatgc cgaggcggtg
     9301 caggctgtcg aggacgagca tcgagaagaa catctgcccg ccgatcatgt cctcctgaca
     9361 gatcggcacc cccagcgagg cggtgtccca gcggttctcg cgcttgaggt ggtggcggat
     9421 ggaggcgtgc agcaggcgga ccttctgcgc ggcggggatg aagcggctgc ctgcctcgaa
     9481 ggcgtcgggc tgcatcaggt ggacggtgaa ctggcccgtc tccgccatgc gtttggacgg
     9541 gtactcgagg ccgtgcgtcg ccgacagcag cttcgccacg tgcgggacga cgtagcaggc
     9601 gggcatggag gcgaaggaga gggcggtgga gatgtgcacg ttgttgtcga tgaagaacag
     9661 gcgggccttc tccatctctc cccagtccac ccaggccggc ggggtggcgg tggcctcgag
     9721 gtagtcgcgg gcgacgtcgg gcaggccgtc cggcagcggg gagccggcgg tggagacgta
     9781 ccgcatcagg gtgttgaagg tgccgacctc gccgcgttcg aagagcgtgg cgacggtggc
     9841 gtcggcgagt tcgtcgccgg tctgccgcag ggcgtccatc gacgcctcgg tgtggatcat
     9901 gatgggctcc ttgttctccg tcgttctcgg ccgtcccccg ccgttctcgg ccgttccccg
     9961 ccgtcccccg tcgttctcgg ccgttccccg ccgttccccg tcagtggcgg cggaccgcgg
    10021 ccgagtgcgc cagggcggtg agcgcggcgg cgggggcggg cggcaggttc agctcgtcga
    10081 gcgcgcgcag ggcctcgtcg acccgcgcgg tgatcatggc ctcgacgcgt tcgggcgcct
    10141 tcaggcgccg catcacctcg cgtacggcct ccggcgcgtc cccgtccggg tcggtcccgc
    10201 cgagcagctc gcgcagccgg tcgcggtcct tttctccggc gagccgccag gtctccgcga
    10261 gcagggccgt cggccggcgg ccgcgcacgt cgtcggcgtc cgccttgccg gtggtctcct
    10321 cgtccccgaa caggcccagc aggtcgtccc tcagctggaa ggcctcgccc agcgggaggc
    10381 cgtacgcgga gtacccctcg cgcagtcgtc cgcccgcccc ggccagggcg ccgccgatca
    10441 acagcggttg ttcgacggtg tacttggcgg tcttgtagcg gatcaccttc agcgaggccg
    10501 ccgtgtcggg ggcggctccg gtgtgcagga tctccaggca ctcgcccgcg atcaggtcgc
    10561 gggcgagcgc ggcccagagc gggcgggcgc ggccgaggta ggcggcgggc aggccgctgg
    10621 tgacgaacag ctgcccggcg agcgacatca gcaggtcacc gacgagcatc gcgagggacc
    10681 gcgcgcccgc ggacacccgc gggtggtgcg cgacggcgcc gcgcagcgcc acgtgcgcgg
    10741 tgggccggcc gtggcgcagc gggctgtcgt cgatcaggtc gtcgtggacg accgcggcgg
    10801 cgtgcacgag ttccatggac gccgccgctc gtagcagcgc ctcgctgtcc ggctgcccga
    10861 ccgctcgcca gccccagtga cagaacgccg cccgcagccg cttgccgtcc gcgacggcgg
    10921 tctccagctg cccggccacc ggacccagcg cggggtcgac ctccaccagc cggtcggcct
    10981 cctcggccgc gtaccgtcgc agcacctcgt cgacgcgtgc cttgaaggcc gccgcgtccc
    11041 accgctcagc caccgtcgcc ggcccgccgg gcgatcgcgt gccgggcgag gacctccagg
    11101 tgggccggcg gcggggacgc gtaccggtcg agcacgagcc gcccgcgcgc ctccaggtcc
    11161 cgctcggcgt cggccgcgac ctcggcggcg tccgaccgtc tcagcagtcc ccggacgatc
    11221 ccgagccccg agcccaccgc ctccaccgcc aggtcggcga gacccgccgc caccagcacc
    11281 acgcgctcgt ccaggccctc gcgggatccc gtttctcgcg tcacgcccac tcccccgccc
    11341 gcggtccggc cgcggtgtcg acaccactgc cctccagcgt cgcggcggac cggcggcggg
    11401 cgcggcggaa ctcaccaacg agtgatcgac tcgtcggcgt gtacgagcgg cggcacgtgc
    11461 cgggctcgtt cggcgcgacc aattcggaag gccctcttgc ccgttggaac cttccttcta
    11521 agaatgctca tgacaaccga aggattttcg gttgcacggt cctcagaggg gaacccccac
    11581 atgaacaagc ctctcgccgg cgccctgctc gccctgctcc tggcaggcgc gacggcggcc
    11641 ccggccgcgg cctccacacc ccaggagacg gccgcgcagg ccactgcccc cacggcacgg
    11701 acccaggccc ccgcggcgca ggccgcggcc gccgtcgact tcgcgggcac ggtcgcgctc
    11761 agcaactgct ccggctcgct cgtccgcgcc cccggctccc tgccgagcga ccccgcgctc
    11821 gtcctctcca acggccactg cctggagacc ggcttccccg cggccggcga ggtcatcaag
    11881 gaccagcggt ccagccgctc gttctccctg ctcaactcgg ccggcaccaa ggtcgcgacg
    11941 ctgcgggcga gcaagatcgc gtacgccacc atgaccgaca cggacatgtc ggtctaccag
    12001 gtgaccaaga cctacgcgca gatccagagc cagtacggca tcagcccgct gaccctcaac
    12061 gacgcgcacc cggtccaggg gacgtcgatc aaggtggtct cgggctactg gaagcggatc
    12121 tacagctgcg acatagacgg cttcgcctac cgcctgaagg agggctcgtg gacctggaag
    12181 gactcggtcc gctacacctc ctcctgcaac accatcggcg gcacctccgg ctcgccggtg
    12241 atcgacacgg ccaccggcaa ggtcgtcgcc gtcaacaaca cgggcaacga gagcggtgag
    12301 agctgcaccg tgaacaaccc gtgcgaggtc gaccagaacg gcgccgtgac ggtccgccag
    12361 ggcatcaact acgcccagca gacctacacg ctcgtcccct gcatcggccc cggcaacgtg
    12421 atcgacctca accgcgccgg ctgcctgctg cccaagccgt gacaccaccg ccccgccggc
    12481 cgccgcccga gcgcggcggc cggcggggcg gccacccacc cgatcccccg gtacgaccca
    12541 cctcgtggtg agtacgcgta ctcatcacga gcgcctcccc cgcggcgaga ctgtgtccac
    12601 cagcgagaga ggccggcgaa ccatgcagca gacccgacgc ccccgaccgt tccgtccctc
    12661 ggccggcgag acgtccaccc gccccaccgc cctccccgcg ctcgtcgccg ggtccctggc
    12721 ggccgcactc ctcctgacgg gctgcatggg ccaggaacgc gtctgcggct ccggccgcta
    12781 cccggtcaag gcggtcggca acaccgacgg ccaggactgc gtcgccgacg gccaggagcc
    12841 cccggagggc tacgtccgct accccgccgg catggttccc gagcacgtcg gcgacaagtg
    12901 ggaccgccac tggggcacga tcgtcgtgga cgccgagggc cgcccgaccc agccctgacg
    12961 cgcaccggca gggggtccac gtccgtcggg ccggacctcc ggccgcgccg ccggccaccc
    13021 cggggggttg ccgtgccgag caggcccgac gcctccctag ccgacgctcc cccgcgtgtc
    13081 agtccgcaat cttccggggt ctcccggacc ccgtcgcgtt gctaccgtcc aggcctgccg
    13141 gacgcaccgt cacgcacgcg acctggaggt ctcgttgagc gcgcagcacc ccacccgcag
    13201 gagcatcctc aagaccgccg gaggcctgtc ggccgccatg gccctgggcg ccggaggcgt
    13261 cctcggggcg gcggcccccg cgtccgccgc cggcgacggc ttcggcctgc ggatcgtcga
    13321 ccgcaacgag gccgaccacc gcatgtggta ctaccggttc cagacggacg cgatcggctg
    13381 gaaccccggc gtcaacgtgc tcctgcccga cgactaccac tggagcggac gcaggtaccc
    13441 ggtgctctac ctgttccacg gcggcgggac cgaccaggac ttcatcacct tcgaccgcga
    13501 gggcgtccgc gactggaccg cgggcaagcc gatcatcgtc gtcatgcccg acggcgggca
    13561 cgcgggctgg tactccaacc ccgtgagctc caacgtcggc ccgcggaact gggagcactt
    13621 ccacatcgcg cagctgctcc cctgggtcga ggcgaacttc cgcacgtacg ccgagtacga
    13681 cggccgtgcc gtggccggct tctcgatggg cggcttcggc gcgctgaagt acgccgccaa
    13741 gtactacggc cacttcgcct cggtgagcgc ccactccggc cccgccagcc tgcgccggga
    13801 caacggcctc gtcggccact gggccaacgc cagttcggcg gccctggacc tgaacggcgg
    13861 cacgatctac ggggccccgt tctgggacga ggcccgggtc agcgccgaca acccggtgca
    13921 gcggatcgag agctaccgcc acaagcgcgt gttcctggtg gccggcacca gcccggaccc
    13981 ggtcaactgg ttcgacaccg ccaacgagac ccaggtcctc gcgggtcagc gcgagttccg
    14041 ctcgctcctg ggcaacgcgg gcatcccgca cgagtggtac gagctgcccg gcggtcactt
    14101 catccgccac gacatgatgc ggcgcgacat cgacggcatc atcggccggc tccgcaaggc
    14161 gtgagccgta cgcccgcacg tcccgtccgt cccgtccgtc ccgagacgat cgaggggagg
    14221 agcgttccgt gcttcccgga ctctcccgcc gcgtgctgag ccgcgtcctc gcggcggcgg
    14281 ccgcactcct gccggtactg gtggccgcga ccccggccac cgccgggccc gccggggcca
    14341 ccggccccgt cctggcgtgc cccaccgcgg gtttcgtgag ccagccgttc cacgcgggcc
    14401 acaacggcgt cgacatcgcc aacgacgtcg ggacgccgat ccacgcggtg gccgacggcg
    14461 aggtgaccat ctccgggtac accggcgact acggccagtg gatccgcgtc cggcacccgg
    14521 acgggaggac gtccgagtac gggcacatgt cccggcggga cgtctcggtc ggcgaccgcg
    14581 tgacggccgg tcagcagatc gccctgatgg gcgccgaggg caactcggac ggccctcacc
    14641 tgcacctgcg gatctggggg gacctgtcgt actcgtacgg catcgacccc gaggtctacc
    14701 tggcggaggg cggcgtgatc ctgccctgcg tcccgggcag cggtccgcgg cccgcacccc
    14761 tggtgtatcc ggcggaatcg gggcgggtgg tgtcggcgcg gtccgcggac ggccgcctgg
    14821 aggtgttctc cgccggcgcc gacggcgtcc accacgcctg gcagcgggag gcgaaccgcg
    14881 actggtcgga gtgggaggcg ctcggcgggc ccggtgacgc ccagctggcg atcgcgcccg
    14941 acgcggacgg ccgcctggag ctgttcgcga tcgacgggaa caccttccgg caccgctacc
    15001 agctctcccc gtcgggcggc tggtccggct gggaggactt cggcggcggc ggtcacgaca
    15061 tcgcggccgg tgtgaacgcg gacggccgca tcgaggtctt cgcctcggga ccggccggcg
    15121 tgttccaccg gtaccaactg gccccgaacg gcggctggtc cgcgtgggag gcgacgggcg
    15181 gcgggcccgc cggcagccgc atcgagatgg agaagtcgcc cgacggccgt ctcgaggtgt
    15241 tcgcgctcaa cggcagttcc ttccagcacc tgtaccagac cgcaccgaac ggcggctggt
    15301 ccgcctgggg cgacttcggc ggcggcggtc acgacctcac cgtcgaccac aacgccgacg
    15361 gcaggatcga ggtgttcgcc tcgggaccga tcggggtctt ccacaagtac cagaccggtc
    15421 ccacgagttg gtcggactgg gaggggaccg gcggccccgc ggacgcacag ctcagcagcg
    15481 agcgcacggc cgacggccgc gtcgaggtct tcgccatgaa cggccggacg gccgtgcacg
    15541 cctggcagac cggggtgaac gcgccctacg gcgcgtggga acccttcggc gggggcggca
    15601 ccgaggtcac cgccacctcc aacgccgacg gcaggatcga ggtcttcggc accaacccca
    15661 ccggtacgta ccacatctgg cagaccggct tcgcggcctg gtccccctgg ggctgggtca
    15721 acggcaccgc gggccccggc ctcgactgac ggttccccgg gcccctgtcc ccggcccccg
    15781 gccgcctgct cccttcggcc cctcggcccc cggccgcctg cccccctcgg cccctggagt
    15841 gattcatgct tccgatcagc agaaggaacc tgctccgggg cgccgccggc gcgggcgcgc
    15901 tctcgatcac cggagccgcc cgcgccgcgg ccgcggccgc cggcgccgtc ccgccgcccc
    15961 gatgggtcgg cgcgggcccc ttcgcccgcg tgtacgaccc ctcaaccgcc gcgggaccgc
    16021 gctacctcaa cgaccacacg ctgatcaggg cccagggccg ctggcacctg ttcgcgatcg
    16081 tcggggacgc cgcgccgccc ggcgagtccc cggacagcac ggcggagatc tccttcgccc
    16141 acgcctcggc cccggccccg tacggcccct ggaccaccca cgccgacgcg ctgaccgtcg
    16201 atccgtccta cttcggcgag gagcacctct gggcgccgca cgtcgtcgag gcggacggca
    16261 ggttcctgat gttctacgcc gcgggcggcg cgagcggtgc cgcgatcaac ctggccacgt
    16321 cgaccgacct gttcacctgg acccgcgagc cgtcggggcc gctgttccgg gggctcgcgg
    16381 cccgtgaccc catggtcctg cgggtcggcg gcgagtgggt catgtactac accgagctgt
    16441 cgggcgcggg cggccaccac gtcgtggcct gccgcaggtc cgccgacctg gtgcactgga
    16501 gcgagccggg cgtcgcgttc accgacgcga gcacggacgc gaccgtctcg gtcaccgagt
    16561 ccccgtacgt cgtcgaacgg gacggctggt actacctgtt catcgggccg cgcaacggct
    16621 acgagggcac cgacgtcctg gcctcgcgcg acccgttccg cttcgacctc accggcgccg
    16681 cgggccacgt ccccggtcac gcggtggagg tgttcgccga cggggaggcc tggtacgcct
    16741 gcgccgcggg ctggttcgag cagggcctgc acctcgcccc cctccagtgg cgggacacgc
    16801 caccgccctg gcagagcccg gacgatccgg tggcgggcct cgacgtggcg ggccggctca
    16861 cggtgttcgc gctcgacgcc ggcgaccgct ccatgctgcg gcgcgtccag ctggccccgg
    16921 acacggacac ctggtcggag tgggagacct tcggcgggcc ggccggcgcg gtccccgtgc
    16981 tggggcggaa cgccgacggc cgcctggagg tgttctcgct cgcgccgggc ggcgtcaacc
    17041 tgcaccaccg cgtccagcgg ccggacggcg gctggtacgg ctgggaggag ttcggcgggc
    17101 cggccggcgc ggcccccgcc gtggcccgcg acgccgaagg ccggctggag gtcttcgcgt
    17161 cgagccccgg cgcctcctcc ttcgcccggc ggcgccagcg gtcgcccggc tcgacggcct
    17221 gggacgcgtg ggagcccggc ttcggcgggg ccgcgggggc tccgccggtg gtcgcggcca
    17281 acgcggacgg ccggctggag gtgttcgtcc tggcggccgg cggcgccggg ctccgccacc
    17341 gctggcagga gtcccccggc ggcgcctgga ccggcgcgtg gcacgccttc ggcacggcgg
    17401 ccggcgccgc gccccgggtg gcccgggacg gcagcggccg cctcaccgtc gccgcgatcg
    17461 gtccgtccgg cgtggggacg ttcgtccggc ggcagagcgt gccgagcggc ggctgggacg
    17521 gctggcagcc gctgttcgac tggagcgccg ccgccccggc gttcgccgcc aacgcggacg
    17581 gccgcctgga ggcgttctcc ctcagccccg gcggcgcccg gctcgtgcac cgctggcaga
    17641 actcgccggg cggcgcctgg gatcccgtca ccgagttcgg cgaacccggc gtgcggctcg
    17701 cggccacgcc gtcggccgcg ctcgactcca ccggacggat ccacgtcttc gccgtcactc
    17761 ccggcggcct ggtacggacg cgggtgcagg cgtggcccag cggcggctgg cggccgtgga
    17821 cggccttcgg cgaccgcgcg gtcgtccccg tggtgtcggg cggtcccgca ctctgagtgc
    17881 ccgcggcgca gcgctccgta cggatcccgc cacgtacggg gagcgcaggg cgggttccac
    17941 cgccctcacg aacctccccg gatcgcccct taccgacctc cgggcgtggt gaccttgccc
    18001 accttgcgtg agggcggccg tccgtccgcg gccgcggccc gagggtgcgc ggcaccgggt
    18061 cacggccgcc gactcgttcg ggcctcctcc ccgagccgct cgcccggggg cggggacgca
    18121 ggccgccgca gagggcggaa atcgacatca aagcgccgcc cccgcccggt gcccgggtgg
    18181 cctgggtcac agcccggtgc cacccgtcgg cgggcacctc cgcgggcccc gcggaggcgt
    18241 tccgcgcccc tcggcggcgg cccgtcggcg acccgcggcg gcgcccgccc gaagtggccg
    18301 aagcacgccg gtgaactccc ctgaccggtc agtatcgttc ctcgtccgac aaccgcgacg
    18361 ggacgaagag gggggacgga ccgcgatgac gccgccgcgc gacgccggcg acaccacgga
    18421 gcacgaccgc gcggacctgc tcccgcccgg ctaccgggtg ggcgactggg cggtcacgga
    18481 gctgatcggc gccgggggct ggtccacggt gtacgcggca cggccggtcg aggccgctcg
    18541 gagccgtcct gcccgggacc ggggcgacga cgtggcgctc aaggtcatgc cgaccgcggg
    18601 gctcgcaccg cgccaggcgc gcaggatcgt ggagtccgcc cggcgcgagg tcgaactcgg
    18661 gcgcagggcc gggcatcccc ggctgatcgg cctgcgggag tccttcgtcc tgtccgcgcc
    18721 ggaccggccc gcggtggacg gcgcgatcgt gctggtcatg gagcgggcgg cgggctccct
    18781 gcgcgaactc ctcgacgcgg gggtgtccgg gggcgagcgc ggcggtctga tcgcggggat
    18841 ctgcgagggc ctcgcccacc tccaccggtc gggctgggtg cacgccgacc tgaagccgga
    18901 gaacgtgctg ctcggccggg acggttccgt gcgcctctcg gacttcggcc tcgccacgga
    18961 gctgaccggg acgcacgggt acgtgcctcc gctcggcacc ctggactacc tgccgcccga
    19021 gcgctggcgg gcgccgctcg gggagctcgg cgtgcaggtc cgcccgagtg ccgacatctg
    19081 ggccctgggt gtcgtcatcc acgaggtgtt cgcctccggt gcctcgccgt tccccggtgc
    19141 cacgccactg gcgcggggcg ccgccgtgca ggagtacggc gaggggcgcg cgccgctgcg
    19201 catggacctc gcggtgccgc cgttctggcg cgccctggcc gccgactgcc tggccccgac
    19261 gcacgcggcg cgcgccccgc acacggccga gagcctgctc gcccgcatcg ccgcgcacga
    19321 ggggacgcgc ggcgcccggg tacgaggggc gcggagccgg gcccggagcg ccgtgctcgc
    19381 cggtgtgctc tgcgcgggcg tgggcgcgac cctgtggtcg gacgcggtac gggaggacgg
    19441 gttcgcggac ccggaccgtg cgggcgcggc cgtcgacacg gtccgggtgt tcaacgcgga
    19501 gcggggctgc caggaccggg ccgaccggga cccgcagtgc agtctgggcc tggcgatcga
    19561 tccgctgcgg ccgtacgcgg cgggcaacgt cgtaccgacc cgggtgtggc acggcgacga
    19621 cctcaccgcc gactgccggc tgttcgacgg gcagcccgtc atcgacgagg aggacctcca
    19681 gtccaccctc tggttccgcg tccgtctccc gcgcggttcg gcgtaccccg ccgcctggct
    19741 ccccgccgtg cgcacgaagg accggcccgc gctgccggga tgcccgcgtc ccgcgaccgc
    19801 gcgctgacgg cccccggtga gcggcatgcc ggtcaccggg ggcctcgcgg accgggggac
    19861 gggccccggc tagtcgatcg ccgggccggc gtcgttcagc cagccccagt tcgcccaggt
    19921 ggagaagccg gtctgccagc ggtggtaga
//
