LOCUS       NZ_JH941044            10816 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_JH941044
VERSION     NZ_JH941044.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 455737)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 455737)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Draft Genome Sequence of Streptomyces sp. SS, which produces uridyl
            peptide antibiotics sansanmycins
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 455737)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 407448
            Orig. end                         :: 418264
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JH941044.1.
            Bacteria and source DNA available from: Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10816
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10816
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10816
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5816](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5816)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(797..1468)
                     /locus_tag="Y19_RS0128210"
     CDS             complement(797..1468)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126587.1"
                     /locus_tag="Y19_RS0128210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017240913.1"
                     /transl_table=11
                     /translation="MAVIHHTTMQPTKLELLTAWLPTRSWYTEGDGGPRPVKAGGFRLD
                     DPEGEVGIEFMAVADGTGDDAVVHLVPMTYRGAPLEGAEHALIGTSEHGVLGTRWIYDG
                     THDPVLVAQLYALLAGNAVAQHQSQDDTPDPTVVAAYTPGADAAELVRAADGSGHTDIV
                     VRTLGTPDATELTLRVRRVLRAGTDTAPAAGRLTADWLLPDGTTARGACVDVLAAGGPL
                     G"
     gene            1622..2863
                     /locus_tag="Y19_RS0128215"
     CDS             1622..2863
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006344713.1"
                     /locus_tag="Y19_RS0128215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_026058511.1"
                     /transl_table=11
                     /translation="MRYSRTPRSRRVCAVLAALGVFAAPVGVGTAFAAEPPVPAPVVAG
                     AVPAAESDFPELTSAVAARLDRAVQDVMKEAGVPGVSVALSAPGKGTYIRSFGVADKAT
                     GQAMNPGLYMRIGSETKTFTVTAVLELVDRGKVALDDPISKYVDGVPNGDRITLRNLAS
                     MRSGLFNYSADEGFYKALTSDPYRPFTPRELLAYSFKHPVSFQPGAEFDYCNTNLILLG
                     LVVEKAGGMPLHEFVRKNVIEPAGLRHTVFPTDAAFPSPHAHGYTVQTASGKLEDSTDW
                     NPSWGWAAGAMISDLQDMRSWARTVATGTLLTPKTQAERLKTYPSGIPGAGYGLGIFDI
                     QGWIGHNGSLPGYESLTLYLPESQATLVVLLNTDVLHDDTEPSTLFGQAITRIVTPDHV
                     FDIPVTAPPPSPKG"
     gene            3050..3511
                     /locus_tag="Y19_RS0128220"
     CDS             3050..3511
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0032784 - regulation of DNA-templated
                     transcription elongation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952304.1"
                     /locus_tag="Y19_RS0128220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GreA/GreB family elongation factor"
                     /protein_id="WP_017240915.1"
                     /transl_table=11
                     /translation="MTGGPEPISAAAREALRRELADLRTERDSVAATLGGPDDEVGDRA
                     DQADELRRADELDRLDARIAEIDGRLAEGAAAGTPPTDAIGVGSSVTVRFSDGTESAFH
                     IGELADADDPALVTADSPLGRALVGRRTGDTVTYATPSGRTTAVVLSLG"
     gene            3516..4337
                     /locus_tag="Y19_RS0128225"
     CDS             3516..4337
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018520635.1"
                     /locus_tag="Y19_RS0128225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017240916.1"
                     /transl_table=11
                     /translation="MPEATADGRADSQAREVDRKGGPGHTVLMALALALPITKVAYTVG
                     GGDAVRDVLVGMEPGNWPDVVLGMVITDPLLGSVLGVVASRVVFALFAARGAIPLRGGL
                     AGAARRAALTVVNPVAVGVIDTCFFGPWWGLATGLAAYALRKGVVVEYRTGRRRPHHGH
                     GPAGDAPGDGYRPPAWLRRVASVEQWAAGCLAVVVLPLLAFVSALDGQSWTTIVTCRVT
                     SGTDTATDRLIELGREGDGVVGWNLDTEQISNGFGCTSDEGRYVREPWWRT"
     gene            complement(4362..4997)
                     /locus_tag="Y19_RS0128230"
     CDS             complement(4362..4997)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952221.1"
                     /locus_tag="Y19_RS0128230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1345 domain-containing protein"
                     /protein_id="WP_017240917.1"
                     /transl_table=11
                     /translation="MNRLLAGAVSRLAGSALVGAAAGAVVAWPTRAPLGVLAGIAVAET
                     VFVVTGWLVLWPMDATTTHHNVRREEFRPVVEELAVVGAAVCGLVGIVVMLLVGDSDLG
                     HAAAATALCGCFMAWAALHLTYATRYAYLYYALKPGGGIDFNSRIPPRYSDFLYFSYNL
                     GMTYQVSDTNVSSTRIRAVALRHCLLSYVFGASILATTINLVTGAVTG"
     gene            complement(5001..5816)
                     /locus_tag="Y19_RS0128235"
     CDS             complement(5001..5816)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566631.1"
                     /locus_tag="Y19_RS0128235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 1 encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_017240918.1"
                     /sec_met_domain="Linocin_M18 (E-value: 3.1e-89, bitscore:
                     292.9, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPDVTNNLHRELAPITPAAWAEIEEEARRTFRRHVAGRRVVDV
                     PDPAGPGLAAVGTGHLTPMDPPAPGVTARLREAKPLVELRVPFTVARAAVDDVERGSKD
                     SDWQPVKDAARTMAFVEDRAVFDGYGAAGVDGLRARSSNPVVRLPEEPSDYPDAVSRAL
                     TSLRLAGVDGPYALLLGADQYRAVSETSDHGYPIAAHLGRMLDGSPIWAPALSGGFVLS
                     TRGGDFELLLGQDVAIGYSGHDENGIHLYFHETLTFLTYTDEAVVVLEA"
     gene            complement(5813..6811)
                     /locus_tag="Y19_RS0128240"
     CDS             complement(5813..6811)
                     /GO_function="GO:0004601 - peroxidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566630.1"
                     /locus_tag="Y19_RS0128240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Dyp-type peroxidase"
                     /protein_id="WP_017240919.1"
                     /transl_table=11
                     /translation="MAVPQPVVASPLRAAVFLVATVNPGGETAVREGLQDLAGLARSVA
                     FRAPDDRLSCVAGISSGAWDRLVGGPRPRDLHPFVPLRGPRHRAPATPGDLLFHLRARR
                     MDLCFELARLIVDGLGAAVTVVDEVHGFAYFDQRDLLGFVDGSENPAGTTALDAVHIGD
                     EDPEFRGGSYVIVQKYVHDMAAWDALTEEEQGRVVGRAKASNVELSDDAKPPNSHVALN
                     TIVDEDGVQQQILRDNMPFGRVGSGEFGTYFIGYARTPAVTERMLRNMFLGDPPGNTDR
                     ILDFSTAVTGGLFFVPSADLLDDLPAAAPPAAAAVPGDSLGIGGLKGAPVP"
     gene            7076..9321
                     /locus_tag="Y19_RS40330"
                     /pseudo=""
     CDS             7076..9321
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524657.1"
                     /locus_tag="Y19_RS40330"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="FdhF/YdeP family oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MGPTPEGEPRFEPYHHPAAGWGAAKSVTNFLVREKALVDGPRAIM
                     RMNHENTGFDCPGCAWPDDTKGLHLDICENGIKHVTWEMTSKRVGREFFATHSVTELAG
                     WSDYDLENQGRLTEPMVYDPESDHYVPISWKDAFEVVGRALRGLDDPNQASYYTSGRLG
                     NEATFLYQLMARELGTNNLPDCSNMCHEASGRALQASLGTGKGTVDLADWETADALFIF
                     GVNAASNAPRMLTALAEAYHRGAAIVHVNPLVEAAATRTIVPHDFTDMALFKSTRTSTL
                     NLQPRIGGDMALVRGMAKAILEQSATDPKALDQEFIERHTHGFDAYRALCEATPWEELE
                     RQSGLTRADILKAARVYGEADRSIVSWCLGITQHEHGVDTVREIVNLLLLRGNLGREGA
                     GPSPVRGHSNVQGNRTCGIDHRPSDAFLDRLAEVCAIEPPRAHGMDTVRTIEAMGRGEI
                     KVFVCMGGNFALAAPDTPVTYAALRTCDLTVQVSTKLKEPSSSPASAAPRRTTSARGSR
                     APPSRTR"
     misc_feature    complement(9845..9860)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.29"
                     /tool="antismash"
     misc_feature    9911..9926
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 24.73"
                     /tool="antismash"
ORIGIN
        1 cgatcgtcct cctggagggc cgtcccgcga tcctggtgca gcggcaggac ttcgccccgc
       61 agcgggacga gtggtcggtg ctcgacgggc accgcgcggc gatccgcgag tccttcctgc
      121 gggtcggccg ggtcgaggtc tccgggcacc cccggctcga ctggatcggc acggcgttcc
      181 tcgtgggtcc gcgcacggtc atgaccaacc gtcacgtggc cgtggagttc agccggctcg
      241 aggacggcca cggccgctgg acgttcgagt acggcatgtc ggcgcgggtc gacccggccg
      301 aggagctgcc cgtcgacggg gtgccgaacg cggccacgac cccgtacgag gtcgtcgagg
      361 tcatcggcat ccacccggac gtcgacatgg ccctgctgcg ggtcgagccg tccgccgacg
      421 gcgccctgcc cagcccgctc gcggtcgccg cggacgcccc cgcgagcgtg ccgggccgcc
      481 cggtgtacgt ggtggggtac ccggcctggg acggccggcg caacgagccc gagtcgatgc
      541 gccggatctt catggacgtc tacaacgtca agcgcctcca gccgggcgcc gccaccgact
      601 tcaccccggg cggcctggtg atgaagcacg actgctccac cctcggcggc aacagcggct
      661 ccccggtctt cgacctgacc gaccaccgcg tcctcggcct ccacttcggc ggccgctacc
      721 gcaccggcaa cttcgccgtc ccgctgtggg agatgatcga cgacccgctg ctcgcccagg
      781 ccgaggtcaa ctgggtctag ccgagcggac ctccggccgc caggacgtcg acgcacgcgc
      841 cgcgggcggt ggtgccgtcc gggagcagcc agtcggcggt gagccggccg gcggccgggg
      901 cggtgtccgt tccggcgcgc aggacgcgtc gtacgcggag ggtcagttcg gtggcgtcgg
      961 gcgtgccgag ggtgcgtacg acgatgtcgg tgtggccgga gccgtcggcg gcccggacca
     1021 gctcggcggc gtcggcgccg ggggtgtagg cggcgacgac ggtggggtcc ggggtgtcgt
     1081 cctgcgactg gtgctgcgcg acggcgtttc cggcgaggag ggcgtacaac tgggcgacga
     1141 ggaccgggtc gtgggtgccg tcgtagatcc agcgggtgcc gaggacgccg tgctcggagg
     1201 tgccgatgag ggcgtgctcg gctccctcca gcggagcgcc gcgataggtc atggggacga
     1261 ggtggacgac ggcgtcgtcc ccggtcccgt cggccaccgc catgaactcg atgccgacct
     1321 cgccctccgg gtcgtcgagc cggaacccgc ccgccttgac cggccgcggc ccgccgtccc
     1381 cttcggtgta ccaggaccgc gtgggcagcc acgcggtcag cagctccagt ttggtgggct
     1441 gcatcgtcgt gtggtggatg acggccatcg tgtgcttctt cctctcgacc gggggcgcct
     1501 gccggccctg aggccgggca ggcgcaacgt aacagacgcg ctcccgggtc ggcgcgcgcg
     1561 gccgtcccgg ccgacctagc ctgaaggtgg agtgttgtcc ccggccggca ggaggcccgc
     1621 cgtgaggtac tcgcgcacac cacggagccg ccgcgtctgc gcggtgctcg cggccctggg
     1681 cgtcttcgcc gcgccggtcg gcgtcggcac cgccttcgcc gccgaacctc cggttcccgc
     1741 acccgtcgtg gccggcgccg tcccggcggc cgagtccgac tttccggagc tgacgtctgc
     1801 cgtggccgcg cggctggacc gggcggtcca ggacgtgatg aaggaggcgg gcgtgccggg
     1861 ggtctcggtc gccctctccg cgcccgggaa ggggacgtac atccgctcgt tcggtgtcgc
     1921 cgacaaggcc accgggcagg cgatgaaccc cggcctgtac atgcggatcg ggagcgagac
     1981 gaagacgttc acggtgacgg cggtgctcga actggtcgac cggggcaagg tcgccctcga
     2041 cgatccgatc tcgaagtacg tggacggcgt gccgaacggc gaccggatca ccctgcgcaa
     2101 cctcgcgtcg atgcgcagcg gtctcttcaa ctactcggcg gacgagggct tctacaaggc
     2161 gctgacctcg gacccctacc ggccgttcac cccgcgggag ctgctcgcct actccttcaa
     2221 gcacccggtc tcgttccagc ccggcgccga gttcgactac tgcaacacga acctgatcct
     2281 gctcgggctc gtcgtggaga aggccggcgg catgccgctg cacgagttcg tccggaagaa
     2341 cgtcatcgag ccggcggggc tgcggcacac ggtcttcccg acggacgccg ccttcccgag
     2401 tccgcacgcc cacggctaca cggtgcagac cgcctcgggg aagctggagg actccaccga
     2461 ctggaacccg tcctggggct gggcggcggg cgcgatgatc tccgacctcc aggacatgcg
     2521 gtcctgggcc aggacggtcg ccaccgggac gctgctgacg ccgaagaccc aggccgagcg
     2581 cctcaagacc tatccgtcgg gcatccccgg cgcgggctac ggtctcggca tcttcgacat
     2641 ccagggctgg atcggccaca acggctccct gcccggctac gagtcgctca ccctctacct
     2701 gccggagtcg caggccaccc tggtcgtcct cctcaacacg gacgtcctcc acgacgacac
     2761 cgagcccagc accctcttcg ggcaggcgat cacccgcatc gtgacccccg accacgtgtt
     2821 cgacatcccg gtgacggctc cgccgccgag cccgaagggg tgaccgaccg tcggggaagg
     2881 cggcgcgcga gaaccggcgc aggtgacggc ccgcggacgc cggggggtcg ccctgcccgc
     2941 gtccccgccc cggtggggcg atccgctgtt agtctcgaaa tgtctcgcaa tgccctcttt
     3001 cgacaccctc accggcactt cttcgtgccg cagcagaacg ggagcagcaa tgaccggtgg
     3061 acccgaaccc atcagcgccg cggctcgtga ggcgctccgg cgggagctcg ccgatctgcg
     3121 caccgagcgc gacagcgtgg ccgccaccct cggcggcccc gacgacgagg tcggcgaccg
     3181 ggcggaccag gccgacgagt tgcggcgcgc cgacgaactc gaccggctcg acgcccggat
     3241 cgccgagatc gacgggcggc tcgcggaagg ggccgcggcc ggcactcccc ccaccgacgc
     3301 catcggcgtc ggcagttccg tgacggtgcg cttctcggac ggcaccgaga gcgccttcca
     3361 catcggcgag ctcgccgacg ccgacgaccc ggccctggtg acggcggaca gcccgctcgg
     3421 ccgggcgctc gtcggccgcc gcaccggcga caccgtgacc tacgcgacgc cctcggggcg
     3481 gaccacggcg gtcgtgctct ccctcggctg acaccgtgcc ggaagccacc gccgacggcc
     3541 gggccgacag ccaggcccgg gaggtcgacc gcaagggcgg ccccgggcac accgtcctga
     3601 tggccctggc actcgccctg ccgatcacca aggtcgcgta caccgtcggc ggcggcgacg
     3661 cggtccgtga cgtcctcgtc ggcatggaac cgggcaactg gcccgacgtg gtgctcggca
     3721 tggtgatcac cgatccgctc ctcgggtccg tcctcggcgt cgtcgcctcc cgcgtggtct
     3781 tcgcgctgtt cgccgcgcgc ggcgcgatcc cgctgcgcgg cggtctcgcc ggcgcggccc
     3841 gccgggcggc cctcaccgtc gtcaacccgg tcgcggtggg ggtgatcgac acctgcttct
     3901 tcggcccctg gtgggggctg gccaccggcc tcgcggcgta cgcgctccgc aagggcgtcg
     3961 tcgtggagta ccgcaccgga cggcgccggc cgcaccacgg gcacggcccc gcgggcgacg
     4021 ccccgggcga cggctaccgg ccgcccgcct ggctgcgccg ggtcgcctcc gtcgagcagt
     4081 gggcggccgg ttgtctcgcc gtggtcgtcc tgcctctgct cgccttcgtc tcggccctgg
     4141 acgggcagtc ctggacgacc atcgtcacct gccgggtcac gagcggcacg gacaccgcga
     4201 ccgaccgcct gatcgagctg ggccgcgagg gcgacggcgt ggtcggctgg aacctggaca
     4261 ccgagcagat ctcgaacggc ttcggctgta cgagcgacga gggccgctac gtgcgggaac
     4321 cgtggtggcg cacctgagag tgggccgccg cgccgggccg gtcagcccgt gacggcaccg
     4381 gtcaccaggt tgatggtggt ggccaggatg ctcgcgccga agacgtagga cagcaggcag
     4441 tgccggaggg cgaccgcgcg gatccgggtg ctggagacgt tcgtgtcgga gacctggtag
     4501 gtcatgccga ggttgtagct gaagtagagg aagtcgctgt accgcggcgg aatccgggag
     4561 ttgaagtcga tgccgccgcc gggtttcagg gcgtagtaga ggtacgcgta ccgggtggcg
     4621 tacgtgaggt ggagcgccgc ccaggccatg aagcagccgc agagggccgt cgccgcggcg
     4681 gcgtggccga ggtccgagtc gccgacgagg agcatcacga cgatgccgac gagaccgcag
     4741 accgcggccc cgacgacggc gagttcctcg acgacgggcc ggaactcctc ccgccggacg
     4801 ttgtggtggg tggtggtggc gtccatgggc cacaggacga gccagcccgt gacgacgaag
     4861 acggtctccg ccacggcgat gccggcgagc acgccgagcg gggcgcgggt cggccaggcg
     4921 acgaccgcgc cggccgcggc cccgacgagc gccgatccgg cgagccggga caccgcgccg
     4981 gcgagcaggc ggttcaccgc tcaggcctcc aggacgacca cggcttcgtc ggtgtaggtc
     5041 aggaaggtca gcgtctcgtg gaagtacagg tggatgccgt tctcgtcgtg gcccgagtag
     5101 ccgatcgcca cgtcctggcc gaggagcagc tcgaagtcgc cgccccgggt ggacaggacg
     5161 aagccgccgc tgagggccgg cgcccagatc ggggagccgt ccagcatccg gccgaggtgc
     5221 gccgcgatcg gatagccgtg gtcggacgtc tcgctgacgg cccggtactg gtcggcgccg
     5281 aggagcaggg cgtacggtcc gtcgacgccg gcgaggcgca gcgaggtgag ggcccggctg
     5341 accgcgtccg gatagtcgct cggctcctcg ggcagccgga ccaccgggtt cgagctgcgg
     5401 gcgcgcagtc cgtcgacgcc ggccgccccg tacccgtcga agacggcccg gtcctcgacg
     5461 aacgccatgg tcctggcagc gtccttgacg ggttgccagt cggagtcctt ggagccgcgt
     5521 tcgacgtcgt ccaccgcggc ccgtgcgacg gtgaacggga ccctgagctc gacgaggggc
     5581 ttcgcctcgc gcagccgcgc ggtgacgccg ggggcgggcg ggtccatggg cgtgaggtgc
     5641 cccgtgccga cggcggccag cccgggtcct gccgggtcgg ggacgtcgac cacgcggcgg
     5701 cccgcgacat ggcggcggaa ggtgcggcgg gcctcctcct cgatctcggc ccaggccgcg
     5761 ggggtgatcg gggcgagttc gcggtgcagg ttgttcgtga cgtcgggggt cgtcatggga
     5821 cgggagctcc tttcaggccg ccgatgccca gggagtcccc ggggacggcg gcggccgccg
     5881 gcggcgcggc ggcgggaagg tcgtcgagga ggtcggcgct cggcacgaag aagaggccgc
     5941 cggtcacggc cgtggagaag tcgaggatgc ggtcggtgtt gcccggcgga tcgccgagga
     6001 acatgttccg cagcatccgc tcggtgacgg cgggcgtccg cgcgtacccg atgaagtagg
     6061 tgccgaactc gccgctgccg acccgtccga acggcatgtt gtcgcgcagg atctgctgct
     6121 ggacgccgtc ctcgtcgacg atcgtgttca gggcgacgtg cgagttcggg ggcttggcgt
     6181 cgtcggagag ttcgacgttg gacgccttgg cccgtccgac gaccctcccc tgctcctcct
     6241 cggtgagcgc gtcccaggcg gccatgtcgt gcacgtactt ctgcacgatg acgtagctgc
     6301 cgccgcggaa ctccgggtcc tcgtcgccga tgtggaccgc gtcgagggcg gtcgtgcccg
     6361 ccgggttctc gctgccgtcg acgaacccga gcaggtcgcg ctggtcgaag taggcgaagc
     6421 cgtggacctc gtcgacgacg gtcaccgcgg cgccgagccc gtccacgatc agccgggcca
     6481 gttcgaagca gaggtccatg cggcgggcgc gcagatggaa caggaggtcg ccgggcgtgg
     6541 cgggcgcccg gtggcgggga ccgcgcagcg gcacgaaggg gtgcaggtca cgggggcgcg
     6601 ggccgccgac gagccggtcc cacgccccgg aggagatgcc ggcgacgcag ctgagccggt
     6661 cgtcgggcgc gcggaaggcc acggaccggg ccaggcccgc cagatcctgg agcccctccc
     6721 tgaccgcggt ctcgcctccg ggattgacgg tggccaccag gaagacggcg gcccgcaggg
     6781 gcgacgccac gacgggctgc ggtacggcca tgctgctccc agagaaagga ccggaaacgc
     6841 ggaggaaagg gacagcgtca gcgtaggtgc gcatgatccg gtacgcagcc cggcgcggcg
     6901 cctcccgccg ccgagtggca ggcgggaaac ggcgggcata gcctcgcgga aggggttcct
     6961 ctgcccaccg tgcccgcgcg tccgcgcggc gaaggggtga agcgcgttga ccaccgacca
     7021 ggacaggaac accgcccagg acggacagga gcctccggag gccaccgcgg cccgggtggg
     7081 ccccaccccc gagggcgaac cgcggttcga gccgtaccac caccccgccg ccggctgggg
     7141 cgccgccaag agcgtgacga acttcctcgt gcgcgagaag gccctggtgg acggcccccg
     7201 ggcgatcatg cgcatgaacc acgagaacac cgggttcgac tgtcccggct gcgcgtggcc
     7261 cgacgacacc aagggcctgc acctcgacat ctgcgagaac gggatcaagc acgtcacctg
     7321 ggagatgacg agcaagcggg tcgggcgcga gttcttcgcc acccactcgg tcaccgaact
     7381 ggccggatgg agcgactacg acctggagaa ccagggccgg ctcaccgagc cgatggtcta
     7441 cgaccccgaa tccgaccact acgtgccgat cagctggaag gacgccttcg aggtcgtcgg
     7501 ccgggccctg cgcggcctcg acgacccgaa ccaggcctcg tactacacct ccggccggct
     7561 cggcaacgag gccacgttcc tctaccagtt gatggcccgc gaactgggca cgaacaacct
     7621 gcccgactgc tccaacatgt gccacgaggc cagcggccgc gccctccagg cgtccctggg
     7681 caccggcaag ggaaccgtcg acctcgcgga ctgggagacg gccgacgccc tgttcatctt
     7741 cggcgtcaac gccgcctcca acgcgccccg catgctcacc gccctcgccg aggcgtacca
     7801 ccgcggcgcc gccatcgtgc acgtcaaccc gctggtcgag gcggccgcca cccgcaccat
     7861 cgtcccgcac gacttcaccg acatggccct gttcaagtcg accaggacga gcaccctgaa
     7921 cctccagccg cgcatcggcg gcgacatggc gctggtgcgc ggcatggcca aggcgatcct
     7981 ggaacagtcc gcgaccgacc ccaaggccct ggaccaggag ttcatcgagc ggcacaccca
     8041 cgggttcgac gcgtaccgcg ccctgtgcga ggccactccg tgggaggagc tcgagaggca
     8101 gtccgggctg acccgcgccg acatcctcaa ggccgcgcgg gtgtacggcg aggccgaccg
     8161 ctccatcgtc agctggtgcc tgggcatcac ccagcacgag cacggcgtgg acaccgtccg
     8221 cgagatcgtc aacctgctgc tgctccgcgg caacctcggc cgggaggggg ccggtccctc
     8281 ccccgtacgc ggacacagca acgtccaggg caaccgtacc tgcggcatcg accaccggcc
     8341 ctccgacgcg ttcctcgacc ggctcgccga ggtctgcgcg atcgagccgc cgcgcgccca
     8401 cggcatggac accgtccgca ccatcgaggc gatgggccgc ggcgagatca aggtgttcgt
     8461 ctgcatgggc ggcaacttcg ccctcgccgc gcccgacacc ccggtcacgt acgcggcgct
     8521 gcgcacctgc gacctcaccg tccaggtcag caccaagctg aaggagccct catcctcccc
     8581 tgcctcggcc gcaccgagaa ggaccaccag cgcaagggga tccagagcac ctccgtcgag
     8641 gactcgatga gcatggtcca cctgtcgatc ggcatgaagc gccccgcctc gccgcatctg
     8701 ctctccgagc ccgccatcgt cgccggcatg gcgcgcgccg cgctgcccga cagcgccacg
     8761 ccgtgggagt ggtacatcga ggactacgac cgcatccgcg acaccatggc caaggcgctc
     8821 gacggcttcg aggacttcaa ccggcgcgta cggctgcccc tcggcttccg catcaagcag
     8881 cccgcccggg aactcgtctt cctcaccccg tccggacgcg ccgagttctc cgccgccgag
     8941 ctccccgacg tcgtcccggc gcccggcacc ctggccctgg gcaccatgcg ctcccacgac
     9001 cagtggaaca ccaccatcta ctccgacaac gaccgctacc ggggcgtcaa gaacctgcgc
     9061 acgctcgtct tcatgaaccg ggccgacatg cgggaacgcg ggatcgccga cctcgggccc
     9121 gtcgacatca cgagcaccgc cagggacggc agccgacgct ccctgcacgg ctacctcgcc
     9181 gtcccgtacg acatcccgcg cggctgcgcc gccggctaca tgcccgagat gaacgtgctg
     9241 tgcgcgctcg gcgactacag cacccagagc gaccagccga tcatgaagca cgtcaacgtc
     9301 acgatcgccc cctccggctg agcggcggcc ctgccggacc gcttccgtcg tcgccggcgc
     9361 gtcgcggtcg gccgtgcgcg gtcggtcgcg gtcggtcgcg gtcggtcgcg gtcagcgcca
     9421 cctgaggaag cgctccagga ggaggtaggc gcgccgttcc gcggcggcga gttcggtggg
     9481 gtcgatctcc gcctgccaca gctcgcccgc cgcggcgtcg tcggcctcgc gcagctccac
     9541 cacggcggcc gccagccgcg tctggacgac cgggaacgac cgcgccgcac gctccgccag
     9601 cacgcgttcg gcctcgtcgg aggccgccgt gcaggcggcg agcgcgcgtt ccgcccgtac
     9661 ggcggcgcgg tcgtgcacca cgagcagcgc gcagcccagc gcgacgccga cccccaggac
     9721 gctgcccagc gcccggtcct cgacgagcgc cccggcgggc gagggcgcgg ccaggtcgga
     9781 gagcagcagg gccagcgggg tgaggaagac gacgccgagg ccgtagttgc gggccaccac
     9841 gtattcgagg aggaattcga gcagcacgat cacgaggacc aggagcacgg gtccggggtc
     9901 cgcggcgagc acgccgaggg cgagcagcag gcccgcgacg gtgccgaggg tgcgctgcac
     9961 ggcccgctgc gtcgccgtgc gcacgttgac cgagtgcagg acggccgcgg cggagatcgc
    10021 cgcccagtag ccgtggccga gcccgaggag gagggcggcg ccgcccgcga tcccggtgcc
    10081 gagcgtcatc cgcagggcgg gcacgagcag gaccgccggg cggccgtggc gcggtcccgt
    10141 caccagctcc gcggcccgca gttcggcggc ttcccggccg gccggccccg cccgctcccg
    10201 gccgcggccc cggcggcccg gccggtccgt cgggggcgcc gtcagctcgg gcagcacgta
    10261 cgggagccgg cgtcggcggc tcgcgagcag ccgggcctgc cggcgcaggt ttcccgccag
    10321 gcccgcgggg tcgtccggcg ggcggctggg cgatccgatg agcagcgacc agcagaggtc
    10381 ggtgagccgc aggagggtgc cgccccggcc gtcccgttcg gcggaggccg gagggagccg
    10441 gccgagggtc cggtacgcct ggaggacggc ggcggtcgcc cggtgccgta cgagcccgct
    10501 gccgccgccc gcctcccaca ggtcggccag ctcccggagc gcggcggcca ccgcgagccg
    10561 ctgcggccgg tccgggtgca cgagccggcc ggccaccgcc aggacccagg cgacggcggc
    10621 accggccgcc gccagggcgg tccgcggcag gacgtcggcg ggggctgaga cggcgttggc
    10681 cgccaccgcg aaggagaaca gcagcaggac ggcgccgagg ccccgcaggc gcgccgcgtc
    10741 gcaggcgagc ttcgcggccc ccgccacgac cgccatggcc gccaccgtca ccgccgcgcc
    10801 cgctcccccg tcccag
//
