LOCUS       NZ_JH941042            10402 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold2, whole genome shotgun sequence.
ACCESSION   NZ_JH941042
VERSION     NZ_JH941042.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 797352)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 797352)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Draft Genome Sequence of Streptomyces sp. SS, which produces uridyl
            peptide antibiotics sansanmycins
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 797352)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 564991
            Orig. end                         :: 575393
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JH941042.1.
            Bacteria and source DNA available from: Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10402
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="1"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10402
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10402
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5402](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5402)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     misc_feature    93..108
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.66"
                     /tool="antismash"
     gene            365..1237
                     /locus_tag="Y19_RS39640"
     CDS             365..1237
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660307.1"
                     /locus_tag="Y19_RS39640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_063739406.1"
                     /transl_table=11
                     /translation="MRPLATPRLTALAISAVLTLGAAGPAAAGEHHPSTAADRAARAPL
                     PEAAALLTQAEALGELGSVTTPVTELVAAALKADSGQLPAADAEALKTKIAAAVEQAKD
                     AAPAPLPDTPAPDVPVTPPELPATPPELPATPPAPELPVTPPAVETPVGLPVKPPVTLP
                     VAAGAKAATAKAAPTDVVDDALATVEKAVAGLLAAVTSGDAAGVVPQVTATLTSLVNLA
                     VATVLGSGLPAPDLAGLPALPALPAGVPELPVDPPELPVDPPQLPVDPPVKPPVAVPDL
                     PVKPPLPVR"
     misc_feature    1457..1466
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.55"
                     /tool="antismash"
     gene            1463..1744
                     /locus_tag="Y19_RS0122075"
     CDS             1463..1744
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035834.1"
                     /locus_tag="Y19_RS0122075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017239811.1"
                     /transl_table=11
                     /translation="MKPTKVAAVVAGSLMALGAAAPAMATEALTPTSLNGGLEAIAANG
                     LKTDVLSSTTEGSPVKSVTDAADQLNETTKGAPLLGGLPVPGGLPLGG"
     gene            complement(2073..2783)
                     /locus_tag="Y19_RS0122080"
     CDS             complement(2073..2783)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Y19_RS0122080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164875178.1"
                     /transl_table=11
                     /translation="MISAALIAAAPMSAASLPVSGSSGGPVGGVVGFVGGAVGGCVVGG
                     WVGGWVGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFVVGGC
                     VGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFVVGGCVGGFV
                     VGGCVGGFVVGGCVGGFVVGGCVGGFVVGGWVGSSPYPSGSSAWAQRSPTASATKPPSS
                     MLSPQTSGGRGAWA"
     gene            2977..3489
                     /locus_tag="Y19_RS0122090"
     CDS             2977..3489
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035837.1"
                     /locus_tag="Y19_RS0122090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_026058312.1"
                     /transl_table=11
                     /translation="MTLRSHAGMGLLMTALASAALASPAAAVEAPVIVPLQGLEPVLPM
                     DAPTVATGVPVPMPGAPTGFQKGLGALPDLTLPSVPLTGTLPNTVVDAPLPELLRDSEP
                     GRALLSSPHSEMKAATPGAVVGNPLEAPRGNGLNGLPDLTKPQVGLLTPVLSGALDPQL
                     GLASDGH"
     gene            3769..>3974
                     /locus_tag="Y19_RS45445"
     CDS             3769..>3974
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015575906.1"
                     /locus_tag="Y19_RS45445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_237749564.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVLAGTGAVALSGAGLAVADSGAEAVAAHSPGVASGN
                     VVQVPVHVPVNLCGNTVNVIGLL"
     assembly_gap    3975..4008
                     /estimated_length=34
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            <4009..4087
                     /locus_tag="Y19_RS45450"
                     /pseudo=""
     CDS             <4011..4087
                     /codon_start=2
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035838.1"
                     /locus_tag="Y19_RS45450"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="chaplin"
                     /pseudo=""
                     /transl_table=11
                     /translation="LNPAFGNTCINADGGHGHGDGGYGG"
     gene            complement(4151..5017)
                     /locus_tag="Y19_RS0122095"
     CDS             complement(4151..5017)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239814.1"
                     /locus_tag="Y19_RS0122095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_017239814.1"
                     /transl_table=11
                     /translation="MVYTRKNQRDLTGAERRKFVAAVLELKRTGAYDEFVRTHIDYYSA
                     DGEGRLRIAHMTPSFLPWHRKFLLEFERALRRVDPTVSVPYWDWTRDDSPASSIWGEDF
                     MGGNGRRADLQVMTGPFAHSAGRWNITYAMTDTRFLTRDFGRPRDPIALPTRAQLDEVM
                     RERVYDVAPWNSTSASGFRNRLEGWAPGRGNERFRIHNRVHRWVGGLMLGGGSVNDPVF
                     WLHHSFVDLVWSRWQQRNPGAAYLPAEPLPLGDAQYRKVAARHQPMAPWGVTPAEMFDH
                     SRVYRYA"
     gene            complement(5001..5402)
                     /locus_tag="Y19_RS0122100"
     CDS             complement(5001..5402)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035840.1"
                     /locus_tag="Y19_RS0122100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_017239815.1"
                     /sec_met_domain="melC (E-value: 5.4e-39, bitscore: 129.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVPRRVALRSLFALAVTALTGGALGRIATRTPSGAPRDPHAFDE
                     MYGGRRLLGFTGPDGAPVALVDGRPLHLMRCADGGYVTPIDHYESCPTPLAATRAAVDE
                     LGTARLSRFAGAHGVPTDPTGGSPRGVHA"
     gene            5553..6056
                     /locus_tag="Y19_RS0122105"
     CDS             5553..6056
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889043.1"
                     /locus_tag="Y19_RS0122105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5949 family protein"
                     /protein_id="WP_026058313.1"
                     /transl_table=11
                     /translation="MTTSNVVSSARSASPLGTLTVIPWSSEPSADSAGTPFLMAYSLGD
                     GRDGPEAGQQAMRAALESMGLSVGDRLFDLEKDAGIHATLLVEGGSAVLNLPFLKVQCP
                     VPDEWQEAARERGQVYLICSVRPWPEAVPGQPVDEARLRSFVSGEEMLADSAHVLMPVR
                     RLQG"
     gene            6076..6726
                     /locus_tag="Y19_RS0122110"
     CDS             6076..6726
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017239817.1"
                     /locus_tag="Y19_RS0122110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_017239817.1"
                     /transl_table=11
                     /translation="MATVNVRGGVPGQRQEEAPRETAGATHGASRAFAWMLMITGAAGV
                     LSGWVITIDKFKLLEDPGFQPGCSLNPVVSCGSVMKSEQAGVFGFPNPMLGLVTYAAVV
                     AVGAGLLAGARYRGWLWLGLNAGMLFGVGFCGWLMYQSLYEINALCLWCCLAWVATIVM
                     FWYVTAQNVRNGVLPAPAGLRTFFGEFAFALPVLHIGIIGMLILTRWWDFWTS"
     gene            6728..7753
                     /locus_tag="Y19_RS0122115"
     CDS             6728..7753
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035843.1"
                     /locus_tag="Y19_RS0122115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyl hydrolase"
                     /protein_id="WP_017239818.1"
                     /transl_table=11
                     /translation="MTPHLTWPRAALTVLLAAVLVLLLAPEPIAPGGRHTGGRAVDEPE
                     TEPLPGVPSGFFTGSDEAGVRRIARVQAWLGGDALSVGHTYLPGDRWSNIEGHPALFGP
                     WARWKAERPGRLFVLNVPLLDRNEEGLPDAEVRAGLRKGAAGAFDGHFRVLGERLVEHG
                     LGDAVLVLGWEMNGTTYSHRCGPDPTAWKAYWRRVVGVLREVPGQRFRFDFTPSRGLDA
                     VAWPRCYPGDDVVDIIGMDAYDQPAGVSFEEQVTEEYGLEHHVRFAAAHGKPVSYPEWG
                     LFRNGDNPVYVRGMLHWFAAHRPVYQTVTDYCPHGVWGCADNPESARIVRGALGASSGR
                     S"
     gene            complement(7716..8333)
                     /locus_tag="Y19_RS0122120"
     CDS             complement(7716..8333)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013001164.1"
                     /locus_tag="Y19_RS0122120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_017239819.1"
                     /transl_table=11
                     /translation="MAAEPTPPPSLRERKKAKTRAAIRKATYRIAADEGWDAATLERIA
                     EAAEVSPSTVVRYFPVREDIVLTDENDALMEAALRARPAGEEPLESLRAVVLEAVRTAF
                     AEEPGAARLRARLMVEIPSVRARLTETTAATGRRLARAVAERTGRAADDLEVRIFTAAA
                     LGALREAAVYWAERDRADDLPALLNRTVDTLRSGLTTPPGRP"
     misc_feature    8333..8347
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.73"
                     /tool="antismash"
     gene            complement(8375..9061)
                     /locus_tag="Y19_RS0122125"
     CDS             complement(8375..9061)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035844.1"
                     /locus_tag="Y19_RS0122125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hemolysin III family protein"
                     /protein_id="WP_017239820.1"
                     /transl_table=11
                     /translation="MTAATPEATPIERPQSLPTKPRLRGWLHAGMFPAVIVAGLVLVAL
                     SDSPRARIACGIYVLTACLLFGISALYHRGEWGPRGEAVLRRLDHANIFLIIAGTYTPL
                     TLLLLPDSTAKPLMWAVWAAAGAGIAFRVFWVGAPRWLYTPCYIAMGWAAVFFLPDFMR
                     AGGIAVLVLVIVGGLLYSAGGVIYGMKRPNPSPRWFGFHEVFHSLTLAAFIVHYVGISL
                     VAYQHS"
     misc_feature    complement(9034..9049)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.85"
                     /tool="antismash"
     misc_feature    complement(9680..9695)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.5"
                     /tool="antismash"
ORIGIN
        1 gtcaacatcc cgatcaacct gtgcggcaac accatcagcg tcatcggcgc gctgaacccg
       61 gccttcggca acgtctgcat caaccggtga tctcgcacgc ctgatcggtc cttccgaagc
      121 cggtgcgccc accccgacgg gtgggcgcac cggctttttc cttgccggca ctggttcggt
      181 cctcgttcgg gcgcaccctc gtgagccgtt cggtgcaacg gcgtacgccc ctcaggggac
      241 aggccgtggg agcggattca ctcgaacgga ggcgtggcgc tcggtagttc tgcggttgcg
      301 gagcgctata cccgcaggca ccgtgagaga gcagttgtcc gacgcataag gaaaaggaac
      361 acatatgcgt cccctcgcta caccccgtct caccgccctg gcgatatccg ccgtcctcac
      421 cctcggcgcg gcgggacccg ccgccgccgg cgaacaccat ccgtccaccg cggccgaccg
      481 ggccgcccgc gcacccctcc ccgaagccgc cgccctgctg acccaggccg aggcgctcgg
      541 agaactcggg tccgtgacga cccccgtgac cgaactcgtc gccgccgcgc tcaaggccga
      601 ttccggccag ctccccgcgg ccgacgccga ggcgctcaag accaagatcg cggccgccgt
      661 cgagcaggcc aaggacgccg ccccggcccc gctgccggac acgcccgccc ccgacgtccc
      721 cgtcaccccg ccggagctcc cggccactcc gcccgagctc cccgccacgc cgcccgcacc
      781 cgaactgccg gtgacaccgc ccgcggtgga gaccccggtg ggcctgccag tgaagccgcc
      841 cgtgacgctg cccgtcgccg ccggcgcgaa ggcggcgacg gcgaaggccg ccccgacgga
      901 cgtcgtggac gacgccctcg ccacggtcga gaaggcggtc gcgggactgc tcgccgccgt
      961 cacctccggt gacgccgccg gtgtcgtccc gcaggtcacc gcgaccctga cgtcgctggt
     1021 caacctggcc gtcgccaccg tgctcggcag cggactgccc gcgccggacc tggccggact
     1081 gcctgccctg ccggcgctcc cggccggggt gccggagctg ccggtggacc cgccggagct
     1141 gcccgtcgac ccgccccagc tgccggtcga cccgccggtg aagcccccgg tggcggtgcc
     1201 cgacctgccg gtcaagcccc cgctgccggt ccggtagtca tccccgcgtc ctgtgccggc
     1261 ccggcgtccg ccgggccggc acaggcgtgt gcgatcggca aatagcaccg gtccgcatcg
     1321 atcgggtgca gtgtcgagaa atccttcctc ccggagtttc cggggagcgc actcctcgtt
     1381 acagaagcag aacgatgtgc aggattcggc caagaacctt gcatagcaag tgacttgaaa
     1441 gtgcagagga aggattcatt ttatgaagcc caccaaggtc gccgcggtag tcgccggttc
     1501 gctgatggcg ctgggtgccg ccgcgcccgc catggccacg gaggcgctga cccccaccag
     1561 cctgaacggt ggactcgaag cgatcgccgc caatgggctg aagacggacg tgctgagcag
     1621 caccaccgaa ggctccccgg tcaagagcgt caccgacgcg gccgaccagc tgaacgagac
     1681 caccaagggt gccccgctgc tcggcggcct cccggtcccc ggcggtctcc cgctcggcgg
     1741 ctgacgttac ctcagtccca ctgcccgtca gggaacttgt ggaggcttca gcgccgcctt
     1801 accccacggt cggctgatcg aatgattttc tgatcagctg ccgtgtggcc cccgcggtgc
     1861 gccctgcgcc gccccatacc gtctggccca tcccacgcga acgtcggcgt ggagcaggcc
     1921 ggtcggagcg aggggggatc ctcgccggtc tctccctttc tccagaggaa gagcgcggca
     1981 gcgaccggca tcctgtcgct gagcggcgga ttcgcccttg ccgcgggctc ccacgccggc
     2041 acgggcgacg ggtcgggccc cgccaccgcc ggtcatgccc aggcacccct gccgcctgac
     2101 gtctgcggcg agagcatgga actcggcggc ttcgtcgcgg aggccgtcgg cgacctctgt
     2161 gcccacgcgg aggaccccga cggatacggc gacgagccca cccacccgcc gacgacgaag
     2221 ccgccgacgc atccgccgac gacgaagccg ccgacgcatc cgccgacgac gaagccgccg
     2281 acgcatccgc cgacgacgaa gccgccgacg catccgccga cgacgaagcc gccgacgcat
     2341 ccgccgacga cgaagccgcc gacgcatccg ccgacgacga agccgccgac gcatccgccg
     2401 acgacgaagc cgccgacgca tccgccgacg acgaagccgc cgacgcatcc gccgacgacg
     2461 aagccgccga cgcatccgcc gacgacgaag ccgccgacgc atccgccgac gacgaagccg
     2521 ccgacgcatc cgccgacgac gaagccgccg acgcatccgc cgacgacgaa gccgccgacg
     2581 catccgccga cgacgaagcc gccgacgcat ccgccgacga cgaagccgcc gacccacccg
     2641 ccgacccacc cgccgacgac gcacccgccg accgctccgc cgacgaagcc gacgacgccg
     2701 cccaccggac ctcccgagct ccccgacacc ggcagcgacg ccgcgctcat gggcgcggcc
     2761 gcgatcagcg cggcgctgat catcggcggc agcgtcgtct acctccgcgg cggacgggtc
     2821 acccgacgcc actgacccga cgggtcaccc gacgccaccg acccgagggg ccggtacgcg
     2881 tcaacgcggg ccctcgcctt caccggtgag ggcccgcgcg ttactgcaca tgggttagtc
     2941 ccgccacgtt tcggccaagg gtctcgttca cctcacatga ctctgcgttc tcacgcgggc
     3001 atgggactcc tcatgaccgc actcgcctcc gccgccctgg cctctcccgc cgccgccgtc
     3061 gaggcaccgg tgatcgtccc gctccagggt ctggagccgg tcctgccgat ggacgcgccg
     3121 accgtggcga ccggcgttcc cgtaccgatg ccgggggcgc ccaccggctt ccagaagggc
     3181 ctcggtgcgc tgccggacct cacgctgccc agcgtgccgc tcaccggcac cctgccgaac
     3241 accgtcgtcg acgcgccgct gcccgagctc ctcagggaca gcgagcccgg ccgggcgctg
     3301 ctcagcagcc cgcactcgga gatgaaggcc gccacccccg gcgccgtcgt cggcaacccg
     3361 ctggaggccc cgcgcggcaa cggtctcaac ggcctcccgg acctgacgaa gccccaggtc
     3421 ggtctcctca ccccggtgct cagcggagcc ctcgaccccc agctgggtct ggcgtcggac
     3481 gggcactgac gccgacgccg cccccgggcg ggtgaagaca cgattcttcc ccgccacccc
     3541 aagggccctc gctcgttgca aggagaggct tgtcgcatgg ccgcggcccg cggaccgagg
     3601 ccgtcccgtc gtatccggcg gcggacggcg tttcggcccg cgggccattc tttcgatttt
     3661 ccttcctccc gttcggacca atggccgtga cctggaacgg agatgggcgt tgaacgggaa
     3721 tgacggccgt gattcctgcg gtcgctttcc acgtccaagg agttcttgat gtctcgcatc
     3781 gcgaaggctg ccgcagttct cgccggcacg ggtgccgttg ccctcagcgg agccggcctg
     3841 gccgtcgccg actcgggcgc cgaggccgtc gccgcccact cgcccggtgt cgcctccggc
     3901 aacgtcgtcc aggtcccggt ccacgtcccg gtcaacctgt gcggcaacac cgtcaacgtg
     3961 atcggcctgc tcaannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngc tgaacccggc
     4021 gttcggcaac acctgcatca acgccgacgg cggccacggc cacggcgacg gcggctacgg
     4081 cggctgatcc ccctcgctcc acacgtgtcc ccccggcccg gcgggccggg gggacacgtg
     4141 cgtgcggccg ctacgcgtag cggtagacgc ggctgtggtc gaacatctcc gccggggtca
     4201 cgccccaggg cgccatcggc tggtggcggg cggcgacctt gcggtactgc gcgtcgccca
     4261 gcggaagcgg ctccgccggc aggtaggcgg cgccggggtt gcgctgctgc cagcgcgacc
     4321 agaccaggtc gacgaaggag tggtgcagcc agaacaccgg gtcgttcacg gagccgccgc
     4381 cgagcatcag cccgccgacc cagcggtgca cccggttgtg gatccggaac cgctcgttgc
     4441 cgcggcccgg cgcccagccc tccagccggt tgcggaagcc ggaggcgctc gtcgagttcc
     4501 agggcgccac gtcgtacacc cgctcccgca tcacctcgtc cagctgggcc cgcgtcggca
     4561 gcgcgatcgg gtcgcggggg cggccgaagt ccctggtcag gaaccgggtg tcggtcatgg
     4621 cgtacgtgat gttccaccgc cccgcggagt gggcgaaggg accggtcatc acctggaggt
     4681 cggcgcggcg gccgttgccg cccatgaagt cctcgcccca gatcgaggac gccgggctgt
     4741 cgtcccgggt ccagtcccag tacggcaccg agaccgtcgg gtcgacgcgg cgcagggccc
     4801 gctcgaactc cagcaggaac ttgcggtgcc agggcaggaa gctcggcgtc atgtgggcga
     4861 tccgcagccg gccctccccg tccgccgagt agtagtcgat gtgggtccgg acgaactcgt
     4921 cgtacgcgcc cgtgcgcttg agctccagta cggcggcgac gaacttccgg cgctcggcgc
     4981 cggtcaggtc gcgctggttc ttacgcgtgt acaccacgcg ggctccctcc cgtcgggtcg
     5041 gtggggacgc cgtgggcgcc ggcgaaccgg gagagccggg ccgtgcccag ctcgtccacg
     5101 gccgcgcggg tggccgccag tggcgtcggg caggactcgt agtggtcgat cggggtgacg
     5161 taaccgccgt cggcgcagcg catcaggtgc agcggccgac cgtcgacgag ggcgaccggg
     5221 gcgccgtccg ggccggtgaa gccgagcagg cggcggcccc cgtacatctc gtcgaaggcg
     5281 tgcgggtcgc gcggggcgcc cgacggcgtg cgggtcgcga tgcggccgag ggcaccgccc
     5341 gtgagagcgg tgacggccag agcgaagagg gaccgcagtg cgacgcggcg cgggacgatc
     5401 atgagtgatc tcctggtggt cggctaatgc cctcagggca caacgatgaa aacccgcgtt
     5461 cgttgcggcg gaaatgccag cggcgtgaat gtcggccgtt cgagtgaaaa cggcgcgggg
     5521 aaagggtggt tggagcatta gcatccggat tcatgaccac ttccaacgtc gtttcctcgg
     5581 cgcgcagcgc ctctccgctg ggaactctca cggtgattcc gtggtccagc gagccctccg
     5641 ccgactcggc cggcacgccg ttcctcatgg cgtactcgct cggcgacggc cgggacgggc
     5701 cggaggccgg tcagcaggcg atgcgggcgg ccctggagtc gatgggcctc tccgtcggcg
     5761 accggctttt cgatctggag aaggacgccg ggatccacgc cacgctgctc gtcgagggcg
     5821 gctcggcggt cctcaacctg cccttcctga aggtgcagtg cccggtgccg gacgagtggc
     5881 aggaggccgc ccgcgagcgc gggcaggtct acctcatctg ctcggtgcgt ccctggcccg
     5941 aggcggttcc ggggcagccg gtcgacgagg cgcggctgcg ctccttcgtc tcaggcgagg
     6001 agatgctcgc ggacagcgcc cacgtcctga tgccggtccg ccgcctgcag ggctgagcgg
     6061 gaagggggtc gcgccatggc gacggtgaac gtacggggcg gggtgccggg acagcggcag
     6121 gaggaggccc cgcgggagac cgcgggcgcg acgcacggcg cgagccgggc cttcgcctgg
     6181 atgctgatga tcaccggggc ggccggcgtg ctctccggct gggtgatcac gatcgacaag
     6241 ttcaagctcc tcgaggaccc cggcttccag cccgggtgca gcctgaaccc ggtcgtctcc
     6301 tgcggcagcg tcatgaagag cgagcaggcg ggggtcttcg gcttccccaa cccgatgctc
     6361 gggctcgtca cgtacgccgc cgtcgtcgcc gtcggcgccg ggctgctcgc gggcgcccgc
     6421 taccggggct ggctgtggct cggcctcaac gccgggatgc tgttcggcgt gggcttctgc
     6481 ggctggctga tgtaccagtc gctgtacgag atcaacgcgc tctgcctgtg gtgctgcctg
     6541 gcgtgggtcg ccaccatcgt catgttctgg tacgtcaccg cgcagaacgt ccgcaacggc
     6601 gtcctgcccg ccccggccgg gctgcggacc ttcttcggcg agttcgcctt cgccctgccc
     6661 gtcctgcaca tcgggatcat cgggatgctg atcctgaccc ggtggtggga cttctggacg
     6721 agctgacgtg accccccacc tcacctggcc gcgggccgca ctgaccgtgc tgctcgcggc
     6781 cgttctcgtg ctcctgctcg cgcccgagcc gatcgcgccc ggcgggcgcc acaccggcgg
     6841 ccgggccgtg gacgaaccgg aaaccgagcc gctgccgggc gtgccgtcgg ggttcttcac
     6901 cggctcggac gaggccgggg tacggcggat cgcccgggtg caggcctggc tcggcggcga
     6961 cgcgctgagc gtggggcaca cgtacctgcc gggcgaccgc tggtccaaca tcgaggggca
     7021 cccggcgctg ttcgggccgt gggcgcgctg gaaggcggag cggcccgggc gcctgttcgt
     7081 gctgaacgtg ccgctgctcg accgcaacga ggaggggctg ccggacgccg aggtgcgggc
     7141 ggggctgcgc aagggcgcgg cgggcgcctt cgacgggcac ttccgggtgc tgggggagcg
     7201 gctcgtggag cacggcctcg gggacgcggt cctggtcctg ggctgggaga tgaacgggac
     7261 cacgtacagc caccgctgcg gtcctgaccc gacggcctgg aaggcgtact ggcggcgggt
     7321 ggtgggggtg ctgcgggagg tgccggggca gcgcttccgg ttcgacttca ccccgagccg
     7381 cggcctcgac gccgtggcgt ggccgcgctg ctaccccggg gacgacgtcg tcgacatcat
     7441 cggcatggac gcctacgacc agccggccgg ggtctccttc gaggagcagg tgaccgagga
     7501 gtacgggctg gagcaccacg tgcggttcgc ggcggcgcac gggaagccgg tctcgtaccc
     7561 ggagtggggg ctcttccgga acggggacaa cccggtgtac gtccggggga tgctgcactg
     7621 gttcgcggcg caccggccgg tctaccagac ggtcaccgac tactgcccgc acggggtgtg
     7681 ggggtgcgcg gacaatccgg agtcggcgcg gatcgtcagg ggcgccctgg gggcgtcgtc
     7741 aggccgctcc tgagggtgtc gacggtccgg ttcaggagtg cgggcaggtc gtcggcgcgg
     7801 tcgcgctcgg cccagtagac ggcggcctcg cggagggcgc cgagcgccgc cgccgtgaag
     7861 atccgcacct ccaggtcgtc ggcggcccgg ccggtccgtt cggcgaccgc gcgggcgagg
     7921 cggcggccgg tggcggcggt ggtctcggtg agccgggcgc gtacggaggg gatctccacc
     7981 atcagccggg cgcgcagccg ggcggccccg ggctcctcgg cgaaggcggt gcggacggct
     8041 tcgaggacga cggcgcggag cgattcgagg ggttcctcgc cggcggggcg ggcgcggagc
     8101 gcggcctcca tgagggcgtc gttctcgtcg gtgaggacga tgtcctcgcg gaccgggaag
     8161 tagcgcacga cggtggaggg ggagacctcg gcggcctcgg cgatgcgttc gagggtggcg
     8221 gcgtcccacc cctcgtcggc ggcgatccgg taggtggcct tcctgatcgc ggcgcgggtc
     8281 ttcgccttct tgcgctcgcg caggctcggg ggaggggtgg gttcggccgc catggctgtc
     8341 attgtcccag gtcggatggg ccggggtggc ccggtcagga gtgctggtag gcgaccaggg
     8401 agatgccgac gtagtgcacg atgaaggccg cgagggtcag cgagtggaag acctcgtgga
     8461 agccgaacca gcgcggggag gggttcgggc gcttcatgcc gtagatgacg ccgcccgcgc
     8521 tgtagagcag accgccgacg atgacgagga cgaggacggc gatgccgccc gcgcgcatga
     8581 agtccggcag gaagaagacc gcggcccagc ccatcgcgat gtagcagggc gtgtacagcc
     8641 agcggggtgc gccgacccag aagacgcgga aggcgatgcc ggcgccggcg gccgcccaga
     8701 ccgcccacat gagcggcttc gccgtggagt cggggagcag cagcagggtg agcggggtgt
     8761 aggtgcccgc gatgatcagg aagatgttgg cgtggtcgag gcgccggagc acggcctcgc
     8821 cccgcggacc ccactcgccg cggtggtaga gcgcgctgat gccgaagagc aggcatgcgg
     8881 tgaggacgta gatcccgcag gcgatgcggg cgcgcggtga gtcggacagg gcgacgagga
     8941 cgaggcccgc gacgatcacg gcggggaaca tgcccgcgtg cagccagccc ctgagccggg
     9001 gcttcgtcgg gagcgactgc ggtcgctcga tcggggtcgc ttccggcgtg gctgcagtca
     9061 tggaacggaa tcgtacctac gcccccgtag gtcccggata cgagtggcga tgctcacgtg
     9121 tgcacccccc tggacatatg ggcggatcca tcggatgatc aaatgagtgc ggtcggcacc
     9181 ggatgagcag ctacgaagca tccgggtcgc ggcccccacg gggcatacat ctaaaaaacc
     9241 cctcaacaag gagcaatcgt ggcgcgcgac aacgcggctc ccaccaccgt ccccacccag
     9301 caccaggagc tcgtctcctg ggtgaacgag atcgccgaga tcacccagcc ggacgccatc
     9361 gtctggtgcg acgggtccga ggccgagtac gagcgcctct gcgaggagct cgtcgccaag
     9421 gggaccttca cgaagctcga cccggtcaag cgcccgaact cgtactacgc cgcctccgac
     9481 ccgacggacg tcgcgcgcgt cgaggaccgg accttcatct gctccgagaa ggaggaggac
     9541 gcgggcccga ccaaccactg gaaggccccg gccgagatga aggagctctt cgcgggctcc
     9601 gagggcatct tccgcggctc catgcgcggt cgcaccatgt acgtcgtgcc cttctgcatg
     9661 ggcccggtcg gctccccgct ctccgccatc ggcgtcgaga tcaccgactc cgcgtacgtc
     9721 gccgtctcca tgcgcaccat gacccgcatg ggccaggccg tcctcgacga gctcggcacc
     9781 gacggcttct tcgtgaaggc cgtccacacc ctcggcgccc ccctggagga gggccaggag
     9841 gacgtgccgt ggccctgcaa ctccaccaag tacatctcgc acttccccga gacccgcgag
     9901 atctggtcct acggctccgg ctacggcggc aacgccctgc tcggcaagaa gtgctacgcg
     9961 ctccgcatcg cctccgtcat ggcgcgcgac gagggctggc tcgccgagca catgctgatc
    10021 ctcaagctga ccccgccgca gggcgaggcc aagtacgtcg ccgccgcgtt cccgtccgcc
    10081 tgcggcaaga ccaacctggc catgctggag cccacgatct ccggctggac cgtcgagacc
    10141 atcggcgacg acatcgcctg gatgcgcttc ggcgaggacg gccgcctcta cgcgatcaac
    10201 cccgaggccg gcttcttcgg cgtggcgccc ggcaccggtg agcacaccaa cgccaacgcc
    10261 atgaagactc tctggggcaa ctcggtcttc accaacgtcg cgctcaccga cgacggcgac
    10321 gtgtggtggg agggcatgac cgaggagcag cccaagcacc tcgtcgactg gaagggcaac
    10381 gactggacgc cggagtccga ga
//
