LOCUS       NZ_AKXV01000041        11419 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold25_1, whole genome shotgun sequence.
ACCESSION   NZ_AKXV01000041
VERSION     NZ_AKXV01000041.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 78529)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 78529)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 64685
            Orig. end                         :: 76104
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AKXV01000041.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11419
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11419
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11419
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:6419](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6419
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            23..904
                     /locus_tag="Y19_RS0112595"
     CDS             23..904
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006380011.1"
                     /locus_tag="Y19_RS0112595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyphosphate--nucleotide phosphotransferase"
                     /protein_id="WP_017238114.1"
                     /transl_table=11
                     /translation="MAKKDGGGKRRQASEPALRDVLRVPEGERVDLSAYDARATPAGPA
                     DKAAGVAATAALAPRLASLQERLYAASTAGDRRRLLLVLQGMDTSGKGGTVKHVIGLFN
                     PSGCRIHAFKAPTAEERNHPFLWRVTKALPQPGEIGIFDRSHYEDVLIARVRDLVPRPR
                     LDRRYAQINGFEKSLAEDGVTVVKVFLHLSYEEQRTRLLERIDNPEKHWKFNPGDIDER
                     ALWPSYQEAYSLALERCTTDEAPWYVVPADRKWYRNWAISKLLLEHLEALAPTYPPADF
                     DVAECRARLLRT"
     gene            1018..1878
                     /locus_tag="Y19_RS0112600"
     CDS             1018..1878
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153326.1"
                     /locus_tag="Y19_RS0112600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_017238115.1"
                     /transl_table=11
                     /translation="MAALGLLGAALVGCGGGAAERPAPGAAPPAVSHEPSPKASAAAAG
                     PKPARVPTAPPTLAQGPGGVTPVYTRRAKGTEKVVALTFDADMTADQGPRAARGEHFDN
                     PQLIATLRRLKVDATVFMTGRWAEEYPDQAKSIGGDPRFEIANHSYSHYAFASPCYGLP
                     TVAGPDMATDVQRAFDAFRDAGAVNVVPYFRFPGGCYDDAALRALAPAGVTAVQWDVVS
                     GDAFAKDADAVADQVLDEVEPGSLVVMHCTRSAAPVTEQAIRRIVPELRARGYRFVKVS
                     ELMGR"
     gene            complement(1919..2569)
                     /locus_tag="Y19_RS44540"
     CDS             complement(1919..2569)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890192.1"
                     /locus_tag="Y19_RS44540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017238116.1"
                     /transl_table=11
                     /translation="MTALLRYQSGLLLRSQRWLAPLLLYVAVVGVGVRAGEPVLGALGL
                     TAAALLPVAAWSVRICVTQEPPAARNVVAAAAGRGRTHLAALLTGTAWPALVGTVAVLV
                     VTGLSDRRGVSALAAVSTGVLAALTCALTGAAVGVLSSRPFLPAPGWSLTVLVLGCLLA
                     LVTTGSPAKHAMTTLITGARTATAHPPALACAGALLLVAAAAALSSRATARLE"
     gene            complement(2566..3489)
                     /locus_tag="Y19_RS44545"
     CDS             complement(2566..3489)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602442.1"
                     /locus_tag="Y19_RS44545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_020477442.1"
                     /transl_table=11
                     /translation="MRLERVGRRHGLRGPWVLREVSLDLPAAGLVRITGANGTGKSTLL
                     RLLAGIDAPTEGRVTGRPARTAYVPERFPAALPFTAADYLVHLGRVQGLGRAAARTRAG
                     DWLERFGAAGHARTPLAELSKGTSQKVAVAQALLADPALLVLDEAWTGLDTGARAELDT
                     AVRERLTAGAAVVFVDHDPRRLAGEADALYGVEASRVRPVRETPAAPARPLVRITASGS
                     RPLPARLPGDPVTEPVPGDEGRAARRLPGEPGTGLAPGHDGRVAHTAAPGALVLTVDAA
                     HSDALLGVLLAEAWHIDHLESEGVRV"
     gene            complement(3486..4163)
                     /locus_tag="Y19_RS0112615"
     CDS             complement(3486..4163)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153329.1"
                     /locus_tag="Y19_RS0112615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AIM24 family protein"
                     /protein_id="WP_017238118.1"
                     /transl_table=11
                     /translation="MKSDLFAGEHLAETAGFPGMTLQNAKSVKYTVNGEMHARQGSMIA
                     YRGDLQFERKGQGIGGLLKRAVTGEGLALMAVRGQGEAWFAHEAQNCFIVEIEQGEAFT
                     VNGRNVLCFDATLHYDIKTVKGAGMTGGGLFNSVFSGYGKIALICEGSPIVIPVTPQAP
                     VYVDTDAVVGWSEQLHTSLHRSQSLGSMLRGGSGEAVQLKLEGQGFVVVRPSELTPQKN
                     SSS"
     gene            4235..4918
                     /locus_tag="Y19_RS0112620"
     CDS             4235..4918
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100702.1"
                     /locus_tag="Y19_RS0112620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_017238119.1"
                     /transl_table=11
                     /translation="MSSNETDLRDEKPQFVLPLVVRIEKDAPPSRTDALETAARAVLEI
                     LTDDRSLGEGEWAQAVTDWQDARIRKVVRRARGAEWRKAGALPGITVDGAEAEVRVFPP
                     VPLDGWPKELAKLQVSGTDLDDPAAPGPVPDGAAVLWLNPELDMSAGKTMAQAGHGAQL
                     LWWAMSAAERTAWQEAGFPLAVRTATAADWAELTVSGLPVVRDAGFTEIAPGSCTVVSA
                     FPNLK"
     gene            5001..6419
                     /locus_tag="Y19_RS0112625"
     CDS             5001..6419
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037016.1"
                     /locus_tag="Y19_RS0112625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_017238120.1"
                     /sec_met_domain="DUF692 (E-value: 1.3e-96, bitscore: 315.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELGMGIGWRPEIAEAVEALPGVDWVEVVAENICAGHLPDSLTR
                     LRARGVTVVPHGVSLGLGGADRPDPARLAALAEKAVALGAPLVSEHIAFVRAGGPLTAT
                     PQLEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLALENIAALISWPGEEMTEGRFLA
                     ELVERTGVRLLIDVANLHTNHVNRGEDPAKALSELPVEAIAYVHVAGGVERDGVWHDTH
                     AHPVPGAVLDVLADLASRVAPPGVLLERDDDFPPAEELAEELSVIRGTVTGARRGAGSN
                     ARAPRVGAVPTRSALAERMPAARQPLLIGAGARVSGGPMPGAAVVAAPTAPETAQEDAR
                     QRLGLAQASLLSALAAGTPVPEGFDSRRIGVQSRALAAKRAGVVAKVAPELPEILGKGF
                     RPEFLSYARSRPMTGGYRRDALDFAEHLLVAGRPENPAARRLLTEWWQDRSGNRPPGRT
                     ARLVRAARHALVRR"
     gene            6422..7450
                     /locus_tag="Y19_RS0112630"
     CDS             6422..7450
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019890186.1"
                     /locus_tag="Y19_RS0112630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_017238121.1"
                     /transl_table=11
                     /translation="MDFLVTLVYLAGVTGIAVAITRVVRMRVGSGGPVHDRYEAAFLNG
                     GPALAALQADGRIAIGGPGIVAVVRPTAYDPVERAVLQEHAAAPHGALHHLRLAVMRHP
                     AVQEIGDGLATRGLVVEPAKRRAAARWCRVLGLAGFCLFPVSMVVSMIDTATDPDFSLP
                     FVFRVAPVIFAAIITAAVCGSLSAGQLTSAGRRAVAAYGRAHASLADAGHLVALHGLRA
                     LPDPVLREQLLAAARVYGRPRRRGRGTRPSSSFSSADAAALGVAADWCGENSFCGGGSG
                     GGSGSSGSCSSGSCSSGSCSSGSCSGGGSGCGGSGSSCSSSSGSSCSSSSGSSCSSSSS
                     SG"
     gene            7520..8278
                     /locus_tag="Y19_RS0112635"
     CDS             7520..8278
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004923613.1"
                     /locus_tag="Y19_RS0112635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_017238122.1"
                     /transl_table=11
                     /translation="MIWVPLLLVACVVAGVGCARVCRATLAAALPDAGDPRGGADPELT
                     LHEAAYLAGGPLRVTDLTLVSMHRGRRLLLAHTGWATVVDAGGAGRDELERAVLGAIGP
                     EGQCPIPSVRPVVAADASVRCIEERLVGRGLAVPAAGRREVAEGLRTVKAGFLLGLVLG
                     TAAALLVPAAERALVIAAFTLPLLASGLCLLIGLVERYPYTRWASPAGQRLLSGLSAAD
                     PLTALATRGPAVLEPELRAAFRGQDTRHRP"
     gene            complement(8471..9159)
                     /gene="hemQ"
                     /locus_tag="Y19_RS42815"
                     /pseudo=""
     CDS             complement(8471..9159)
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888541.1"
                     /locus_tag="Y19_RS42815"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSAPEKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPEDRAGYADE
                     VQELFDQLAAKDITIRGTYDLSGLRADADVMIWWHAETSDELQEAYSLFRRTKLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADETPRDYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGYPDVRANTVASFSLGDYEWILAFEADELHRIVDLMRHLRASEARMHVREEVASP
                     TWWRAWP"
     gene            complement(9177..10640)
                     /gene="hemG"
                     /locus_tag="Y19_RS0112645"
     CDS             complement(9177..10640)
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037013.1"
                     /locus_tag="Y19_RS0112645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_017238123.1"
                     /sec_met_domain="DAO (E-value: 7.4e-14, bitscore: 44.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNADTTGPHVVVAGGGIAGLAAAHRLALAGHRVTLLEAGDRVGGK
                     LLAGEIAGAPVDLGAESLLARRPEAVALARAVGLGDRLQAPGTTTASVWSRGDLIPMPK
                     GHVMGVPGDARAVGGLVSPAGLGRIDRDLELPPTEIGEDIAIGAYVAERMGHEVVDRLV
                     EPLLGGVYAGDAHRISMKAAVPALFEAARVHPTLTAAVRAVQQAGAAVPADAAGAATGL
                     GGAAFLGLDGGIGTLPGAVAAAIRAAGGEILTGTSVTALLRSGATGWRVVTRDRTFDAD
                     AVVLATPAGTAAGLLGGHAPGAAAELDGIDYASMALVTLAFRRSDVPALPGSGFLVPPV
                     DGHTIKASTFSSQKWNWVTDSAPDLFVLRTSVGRHGEEEQVRREDTDLVAASLKDLAAA
                     TGLAARPVATTVTRWTGGLPQYPVGHLARVARVREALAALPGLRVAGAAYDGVGIPACV
                     ASAHRAADEIADEIDATSKRTDPGAGHSS"
     misc_feature    10815..10830
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
     misc_feature    complement(11125..11144)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.45"
                     /tool="antismash"
ORIGIN
        1 gtcgcggcgg aaggaacggc ggatggcgaa gaaggacggc ggggggaagc ggcgacaggc
       61 ttcggaaccc gcgctgcgtg acgtcctgcg cgtcccggag ggcgagcggg tcgacctttc
      121 cgcgtacgac gcccgggcga cgccggccgg ccccgccgac aaggccgccg gcgtcgccgc
      181 caccgcggcc ctcgcccccc gcctcgcctc cctccaggaa cgcctctacg cggcgagcac
      241 cgccggcgac cgacggcgcc tcctcctcgt cctccagggc atggacacga gcggcaaggg
      301 cggcaccgtc aaacacgtca tcggtctctt caatccctcc ggctgccgca tccacgcctt
      361 caaggcgccc accgccgagg aacggaacca tcccttcctc tggcgcgtca cgaaagccct
      421 cccccagccc ggtgagatcg gcatcttcga ccgctcccac tacgaggacg tcctcatcgc
      481 ccgcgtccgc gacctcgtcc cccgcccccg gctggaccgc cgctacgccc agatcaacgg
      541 cttcgagaag tccctcgccg aggacggcgt caccgtcgtc aaggtcttcc tccacctctc
      601 ctacgaggaa cagcgcaccc gcctcctcga acgcatcgac aaccccgaga agcactggaa
      661 gttcaacccc ggcgacatcg acgaacgcgc cctctggccc tcctaccagg aggcctactc
      721 cctcgccctc gaacgctgca ccaccgacga agccccctgg tacgtcgtcc cggccgaccg
      781 caagtggtac cgcaactggg cgatcagcaa gctgctcctc gaacacctgg aggcactcgc
      841 cccgacgtac ccgcccgcgg acttcgacgt ggcggagtgc cgggcacgac tactgcggac
      901 gtgagcggcg atggtgcgtc agctcagtgc gtggactcgg gtgctgctgg tgtcgagtcg
      961 cgagcgttag cgagtttgat cggttaactt ccgatcgtga acattcctgt actaaagatg
     1021 gcggcgctcg gactcctggg cgccgccctc gtcggctgcg gcgggggcgc cgccgagcgc
     1081 cccgcccccg gggcggcacc gccggccgtc tcccacgagc cgtcccccaa ggcgagtgcg
     1141 gccgccgccg ggcccaagcc cgcacgcgtc cccaccgcgc ctccgaccct ggcgcagggg
     1201 cccggcgggg tcacccccgt gtacacgcgc cgtgcgaagg ggaccgagaa ggtcgtcgcc
     1261 ctcaccttcg acgcggacat gaccgcggat caggggccgc gggccgcgcg gggcgagcac
     1321 ttcgacaacc cgcagctgat cgcgacgctg cgccggctga aggtggacgc caccgtcttc
     1381 atgacgggcc gctgggcgga ggagtacccc gaccaggcga agtcgatcgg cggcgacccc
     1441 cggttcgaga tcgcgaacca ctcctacagt cactacgcct tcgcctcgcc gtgctacggc
     1501 ctgccgaccg tcgccggccc cgacatggcg accgacgtgc agcgcgcctt cgacgccttc
     1561 cgcgacgccg gcgccgtgaa cgtcgtcccg tacttccgct tccccggcgg ctgctacgac
     1621 gacgcggcgc tgcgcgcgct cgcccccgcc ggggtgacgg ccgtgcagtg ggacgtggtc
     1681 agcggcgacg ccttcgccaa ggacgcggac gccgtcgccg accaggtgct cgacgaggtc
     1741 gagcccggct ccctcgtcgt catgcactgc acccgcagcg ccgcccccgt caccgagcag
     1801 gcgatccgcc gcatcgtgcc ggaactccgc gcccgcggct accgcttcgt gaaggtctcc
     1861 gagctcatgg gccgatgagc cgatcggcgg ccggggtcgc tcgggaagca ctccgggatc
     1921 actccaggcg ggccgtggca cggctggaca gggccgccgc ggccgccacg aggaggagcg
     1981 cgccggcgca ggcgagggcc ggtgggtggg cggtggcggt ccgggcgccg gtgatcaggg
     2041 tggtcatggc gtgcttcgcg ggagagcccg tggtgacgag ggccaggagg cagccgagga
     2101 cgaggacggt gagggaccag ccgggggcgg gcaggaaggg gcgcgaggag agtacgccga
     2161 cggccgcgcc cgtcagggcg caggtgagcg cggcgaggac gccggtggac acggcggcga
     2221 gcgcgctgac gccgcgccgg tcgctcagcc cggtcacgac gaggaccgcg acggtcccga
     2281 cgagcgccgg ccaggcggtc ccggtgagca gcgccgcgag atgggtacgg ccgcgccccg
     2341 ccgcggccgc cacgacgttc cgggccgcgg gcggctcctg ggtgacgcag atccgtacgg
     2401 accaggccgc gacgggcagc agcgcggcgg ccgtgaggcc gagggctccg agcacgggtt
     2461 cgcccgcgcg tacgccgacg ccgacgacgg ccacgtacag gaggagtggc gccagccagc
     2521 gctgtgagcg cagcagcagg cccgactggt agcgcaggag cgccgtcata cccgtacgcc
     2581 ttcgctttcg aggtggtcga tgtgccatgc ctccgcgagc aacaccccga ggagggcgtc
     2641 ggagtgcgcc gcgtccacgg tgaggacgag ggcgcccggt gcggcggtgt gcgcgacgcg
     2701 cccgtcgtgg ccgggcgcga ggccggtacc cggttcgccc ggcagtcgtc gagcggcacg
     2761 gccttcgtcg ccgggcacgg gctcggtgac cgggtcgccc ggcagtcggg ccgggagcgg
     2821 gcggctgccg gaggcggtga tccggacgag gggtcgggcg ggggccgcgg gcgtctcgcg
     2881 gaccgggcgt acccggctcg cttcgactcc gtagagcgcg tccgcctccc ccgcgagccg
     2941 ccgcgggtcg tggtcgacga agacgacggc cgcgcccgcc gtgaggcgtt cgcggacggc
     3001 ggtgtccagc tcggcgcggg cgccggtgtc gagcccggtc caggcctcgt cgaggacgag
     3061 gagggcggga tcggcgagga gcgcctgggc gacggcgacc ttctggctgg tgcccttgga
     3121 cagttcggcg aggggcgtac gggcgtggcc cgcggcgccg aagcgctcca gccagtcccc
     3181 cgcgcgggtg cgggcggccg cgcggccgag gccctggacg cggcccaggt ggacgaggta
     3241 gtcggcggcc gtgaacggca gggccgccgg gaagcgctcg gggacgtagg cggtgcgggc
     3301 cggacggccg gtgacgcggc cctcggtggg cgcgtcgatc ccggcgagga gccggagcag
     3361 ggtggacttg ccggttccgt tggcgccggt gatccggacg agcccggcgg cgggcaggtc
     3421 gagcgagacc tcccgcagca cccacggccc gcgaaggccg tggcgccgcc cgacgcgctc
     3481 cagcctcaac tcgacgagtt cttctgcggg gtcagctcgc tcggccggac gacgacgaag
     3541 ccctggccct ccagcttgag ctggaccgcc tcgcccgagc cgccgcggag catcgagccg
     3601 agggactggg agcggtggag ggaggtgtgg agctgctcgc tccagccgac gaccgcgtcg
     3661 gtgtcgacgt agacgggggc ctgcggggtg acgggaatga cgatcgggct gccctcgcag
     3721 atcagggcga tcttgccgta gccggagaag acggagttga agaggccgcc gccggtcatg
     3781 ccggcgccct tcacggtctt gatgtcgtag tggagggtcg cgtcgaagca gagcacgttg
     3841 cggccgttga cggtgaaggc ctcgccctgt tcgatctcga cgatgaagca gttctgcgcc
     3901 tcgtgggcga accaggcctc gccctgaccg cgtacggcca tcagcgcgag gccctcgccg
     3961 gtgacggccc gcttgaggag gccgccgatg ccctggccct tgcgctcgaa ctggaggtcg
     4021 ccgcggtagg cgatcatcga accctggcgg gcgtgcatct cgccgttgac ggtgtacttg
     4081 accgacttgg cgttctggag ggtcatcccc ggaaagccgg ccgtctcggc gaggtgttcg
     4141 ccggcgaaaa gatcgctctt catgaggggc atcctggccc ggaagcgatg attcccacaa
     4201 gaatcactcg tcacggcagt ggcagacttg ccgggtgagc agcaacgaga ccgatctccg
     4261 cgacgagaag ccccagttcg tcctccccct ggtcgtccgc atcgagaagg acgcgccgcc
     4321 gtcccgtacc gacgccctgg agaccgccgc gcgggccgtc ctggagatcc tgaccgacga
     4381 ccgttccctc ggcgagggcg agtgggcgca ggccgtcacc gactggcagg acgcccgcat
     4441 ccgcaaggtg gtgcgccggg cgcgcggcgc cgagtggcgg aaggcgggcg cgctcccggg
     4501 gatcacggtc gacggcgcgg aggcggaggt acgggtcttc ccgccggtcc cgctcgacgg
     4561 ctggcccaag gagctggcca agctccaggt ctcgggcacc gacctcgacg accctgccgc
     4621 gcccggcccg gtgccggacg gggcggcggt gctctggctc aacccggagc tcgacatgtc
     4681 ggccggcaag acgatggcgc aggccgggca cggtgcgcag ctcctctggt gggcgatgtc
     4741 ggcggccgag cgcacggcgt ggcaggaggc cggtttcccg ctcgcggtcc ggaccgcgac
     4801 ggccgcggac tgggccgagc tgacggtgag cgggctgccg gtggtccggg acgcgggctt
     4861 cacggagatc gcgccgggct cgtgcacggt ggtgtccgcg ttcccgaacc tcaaatgaag
     4921 ctctgaacgt gcccccctcg gggttcgaac gtcaccgccc gggtcatcac cggggtgact
     4981 gaggaccgaa ggagggggac atgacggaac tcggcatggg catcggctgg cgtcccgaga
     5041 tcgcggaggc ggtggaggcg ctgcccggcg tcgactgggt cgaggtggtc gcggagaaca
     5101 tctgcgccgg ccacctgccc gactcgctga cccggctgcg ggcgcggggc gtgacggtcg
     5161 tcccgcacgg cgtctcgctg gggctcggcg gcgcggaccg gccggaccct gcacggctcg
     5221 ccgcactcgc ggagaaggcg gtggccctcg gcgcgccgct cgtctcggag cacatcgcct
     5281 tcgtacgggc cggggggccg ctcaccgcga cgccgcagct cgaagcgggc cacctgctgc
     5341 cggtgccgcg gacccgcgac gcgctcgacg tgctctgcga gaacgtccgc atcgcgcagg
     5401 acgcgctgcc cgtgccgctc gccctggaga acatcgcggc cctcatctcc tggccgggcg
     5461 aggagatgac ggagggccgg ttcctggcgg agctggtcga acgcacgggg gtccggctgc
     5521 tcatcgacgt cgccaacctg cacacgaacc acgtcaaccg cggcgaggac ccggcgaagg
     5581 ccctttccga gcttccggtc gaggccatcg cctacgtcca cgtggcgggc ggcgtcgaac
     5641 gggacggggt ctggcacgac acccacgcgc atcccgtgcc gggggcggtc cttgacgtcc
     5701 tggcggacct cgcgtcgcgg gtggctccgc cgggggtgct gctggagcgg gacgacgact
     5761 tcccgcccgc ggaggagctg gccgaggagt tgagcgtgat ccgggggacg gtgaccggcg
     5821 ctcgcagggg tgcgggttcg aacgcgaggg cgccgcgcgt gggtgccgtg cccacccgtt
     5881 ccgcccttgc ggaacgcatg cccgcagcca ggcagccgct cctgatcggc gccggcgccc
     5941 gcgtctcggg cggcccgatg ccgggcgccg ccgtcgtggc ggcacccacg gccccggaga
     6001 cggcacagga ggacgcgcgc cagcgcctcg gcctcgcgca ggcctccctg ctctccgcgc
     6061 tggccgcggg aacgccggtg cccgagggct tcgacagccg gaggatcggt gtgcagagcc
     6121 gcgcgttggc ggcgaagcgc gccggagtcg tcgcgaaggt ggcgccggaa ctgccggaga
     6181 tcctgggcaa ggggttccgg ccggagttcc tgtcgtacgc caggtcgcgg ccgatgaccg
     6241 gcgggtaccg ccgggacgcg ctggacttcg ccgagcacct gctcgtggcc gggcgcccgg
     6301 agaacccggc ggcgcgccgg ctgctcacgg agtggtggca ggaccgttcc ggcaaccgtc
     6361 cgcccggccg taccgcccgg ctcgtacggg ccgcccgtca cgcactcgta cggagatgac
     6421 catggacttc ctcgtcaccc tcgtctacct cgcgggcgtc accggcatcg ccgtggccat
     6481 cacccgggtc gtccggatgc gcgtcgggtc cggcgggccc gtccacgacc ggtacgaggc
     6541 cgccttcctc aacggcggcc ccgcgctggc cgccctccag gcggacggca ggatcgcgat
     6601 cggcggaccc ggcatcgtgg cggtcgtgcg gcccaccgca tacgacccgg tggagcgcgc
     6661 ggtgctccag gaacacgccg ccgccccgca cggggccctg caccacctgc ggttggccgt
     6721 gatgcggcac ccggcggtgc aggagatcgg cgacggcctc gccacgcgcg ggctcgtcgt
     6781 cgaaccggcg aagcggcggg ccgcggcccg ctggtgccgc gtcctcggtc tcgccggctt
     6841 ctgcctcttc ccggtctcga tggtcgtctc catgatcgac accgccaccg acccggactt
     6901 ctcgctcccg ttcgtcttcc gggtggcacc cgtgatcttc gccgccatca tcaccgcagc
     6961 cgtctgcggg tcgctctccg ccgggcagct cacctcggcc ggccggcgcg cggtcgccgc
     7021 gtacggtcgc gcccacgcct cgctcgcgga cgccggccac ctcgtggccc tgcacgggct
     7081 gcgtgccctg ccggaccccg tactgcgcga gcagctcctc gccgccgcac gggtctacgg
     7141 gcggccgcgg cggcgagggc gcggcacgcg tccgtcgtcc tcgttctcct cggcggacgc
     7201 ggcggccctg ggcgtggccg ccgactggtg cggagagaac agcttctgcg gcggcgggag
     7261 cggcggcgga tcgggctcct cggggtcctg ctcgtccggg tcctgctcgt ccggttcctg
     7321 ctcgtccggt tcctgctcgg gaggcggctc cggctgcggc ggctcgggca gttcgtgttc
     7381 gagttccagc ggcagctcgt gttcgagttc cagcgggagt tcgtgctcca gctccagctc
     7441 cagcggctga ccgctcgtcg gcacggcggg cgcggccatt cgagtggcgg ggccgcccgt
     7501 cgtcccgtag aactcggaca tgatctgggt tcccctgctc ctggtggcct gcgtcgtggc
     7561 gggggtcggc tgcgcgcggg tctgccgcgc gacgctcgcg gcggccctgc ccgacgccgg
     7621 tgacccgagg ggcggagccg atccggaact gaccctccac gaggcggcgt acctcgcggg
     7681 cggtccgctc cgggtcaccg acctgacgct ggtgtcgatg caccggggac ggcggctgct
     7741 gctcgcccac accggctggg cgaccgtggt ggacgcgggc ggcgcgggcc gggacgagct
     7801 ggaacgcgcg gtgctcggcg ccatcgggcc cgagggacag tgccccatcc cttccgtacg
     7861 tccggtggtc gccgccgacg cttcggtgcg gtgcatcgag gagcggctcg tcggccgggg
     7921 gctcgcggtg ccggcggcgg ggcgacggga ggtcgcggag gggctgcgga ccgtgaaggc
     7981 gggcttcctg ctcggtctgg tgctcgggac ggccgcggcg ctgctcgtcc cggccgccga
     8041 acgggccctg gtgatcgccg cgttcacgct gccgctgctg gcgtcggggc tctgtctgct
     8101 gatcggcctg gtcgagcgct acccgtacac gcgctgggcc tcaccggccg ggcagcggct
     8161 gctctccggc ctctccgccg ccgatccgct caccgcgctc gcgacgcgcg gtcccgccgt
     8221 cctggagccg gagctccgcg cggccttccg ggggcaggac acccggcacc ggccgtgagg
     8281 aggtccgggg ccgcctgaaa aggccccgga aatgacgccg gtgcggcgcg cgtcacgcgc
     8341 gccgcacccg gagccggacc cggtgtcgct ggagcggcag gcacatgtgg tccgcctgcc
     8401 gtctgatctt ccgggtcgag ggatggcgcg cccggccggg agccgggccg ccaccaggtt
     8461 cgtacggccg tcaggccagg cccgccacca ggtcggcgac gctacctctt cgcggacgtg
     8521 catccgggcc tcggaggcgc gcaggtggcg catgaggtcg acgatgcggt gcagctcgtc
     8581 ggcctcgaag gcgaggatcc actcgtagtc gccgagcgag aaggaggcga ccgtgttggc
     8641 gcggacgtcg gggtagccgc gggccatctt gccgtggtcg gcgagcatgc ggcgacggtc
     8701 ctcgtcgggc agcaggtacc agtcgtagga gcgcacgaag gggtacaccg agacgtagtc
     8761 gcgcggggtc tcgtcggcca ggaaggccgg gatgtgcgac ttgttgaact cggcggggcg
     8821 gtgcagcgcc atgttcgacc agaccggctc cagagcgcgg cccagcttgg tgcggcggaa
     8881 gaggctgtac gcctcctgga gctcgtcgct cgtctcggcg tgccaccaga tcatgacgtc
     8941 ggcgtcggcg cgcagaccgg acaggtcgta cgtgccgcgg atcgtgatgt ccttggcggc
     9001 gagctggtcg aacagctcct ggacctcgtc ggcgtagccg gcacggtcct cgggcagaac
     9061 gtcgcgcagc ttgaagacag accacagggt gtagcggatg acctcgttga ggtccttcgc
     9121 cttcttaccg gcgttcggga tcttttcggg cgcactcata cgcctattct cgcccgtcac
     9181 gaggagtgcc ccgcaccggg gtcggtcctt ttcgacgtgg cgtcgatctc gtccgcgatc
     9241 tcgtccgccg cgcggtgggc cgaggcgacg caggcgggga tgccgacgcc gtcgtacgcg
     9301 gctcccgcga cgcgcagtcc gggaagggcg gcgagcgcct cgcggacgcg tgcgacgcgg
     9361 gccaggtggc cgaccgggta ctggggcagg ccgccggtcc agcgggtgac cgtggtggcg
     9421 acggggcggg ccgcgagccc ggtggcggcg gcgaggtcct tgagggaggc ggcgacgagg
     9481 tcggtgtcct cgcgccggac ctgctcctcc tcgccgtggc ggccgacgga ggtgcgcagc
     9541 acgaacaggt cgggggcgga gtcggtgacc cagttccact tctggctgga gaaggtggac
     9601 gccttgatgg tgtggccgtc gacgggcggt acgaggaagc cggagcccgg cagggcgggc
     9661 acgtcggagc ggcggaaggc gagggtgacc agggccatgg aggcgtagtc gatcccgtcg
     9721 agctcggcgg cggcgcccgg ggcgtggccg ccgaggaggc cggccgcggt gccggcgggg
     9781 gtggcgagga cgacggcgtc ggcgtcgaac gtccggtcgc gggtcacgac ccgccagccg
     9841 gtggcgccgg agcggagcag cgcggtcacg gaggtgccgg tgaggatctc gccgccggcg
     9901 gcgcggatcg cggcggcgac cgcgccgggg agggttccga tgccgccgtc gagtccgagg
     9961 aaggcggcgc cgccgaggcc ggtggcggcg cccgccgcgt cggcggggac ggccgcgccg
    10021 gcctgctgga cggcgcggac ggcggcggtg agggtggggt ggacgcgggc cgcctcgaag
    10081 agggcgggca cggcggcctt catggagatg cggtgggcgt caccggcgta cacgccgccg
    10141 aggaggggtt cgacgagccg gtcgacgacc tcgtggccca tgcgctcggc gacgtacgcg
    10201 ccgatggcga tgtcctcgcc gatctcggtc gggggcagct ccaggtcgcg gtcgatccgg
    10261 cccaggcccg ccggggagac gagtcccccg accgcgcggg cgtcgccggg gacgcccatc
    10321 acgtggccct tgggcatggg gatcaggtcg ccgcgggacc agacggacgc ggtggtggtg
    10381 ccgggggcct ggagccggtc gccgaggccg acggcgcggg cgagggcgac cgcctcgggg
    10441 cggcgggcga gcagcgactc ggcgcccagg tccacgggcg cgcccgcgat ctctccggcg
    10501 aggagcttgc cgccgacccg gtcgcccgct tcgaggaggg tcacccggtg gccggcgagg
    10561 gccagccggt gggcggccgc gagtccggcg ataccgcctc cggcgacgac gacatggggt
    10621 cccgtggtgt ccgcgttcat gggaccactc tctcaaatcg cccgtctctc cctcgccgcc
    10681 gtccgcctgt cggcggcccg gggcccgggt acggtccgcc gcgcccgttc cgaggccgga
    10741 ccgtgaccgc atcgctaccg ccggacggca acccttaccg cccgcccgta cgtccaaccg
    10801 ccgacattca cccatcaccc ttggggggga ctcatgcgga gcgtacggac gacggcgaga
    10861 gcgcggacgg ctggacgggc ggggacggcg ggccgggcgg ggacggcggg ccgggcgagg
    10921 gcggtcgcgg cggtgctgtt cgcggcctcg ctcgtgctga ccggctgtgg cgccggggcg
    10981 agctcggact cggccgagcg gggggactcg aaggcggggg cgcgcgccga cggcgcggcg
    11041 gcggacgccg accggggcgc cgtcgacggg tcggcggccg gtacggacaa ggaggccgcc
    11101 gacggttcct cgggcgccgg gaagcccggg gcgcaggtgc ccgcgccgca gcacgtcatc
    11161 cgtaccgcct cgctgtccgt cgaggtggcg gacgtgacga aggcgctggc cacggcccgg
    11221 cgggtgaccg cgggcgcggg cgggcgggtc gagaacgaga cgacggagcg ggtcgacgac
    11281 gcgtacgtca cctcgcaggt cgtgctgcgg gtgccgcagg agcggtacga ctccgtcctc
    11341 gccgagctgg cgggcaccgg caagctcatc gcccgcaagg ccgacgccaa ggacgtcacc
    11401 gaccaggtgg tggacgtcg
//
