LOCUS       NZ_AKXV01000039        17724 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold23_1, whole genome shotgun sequence.
ACCESSION   NZ_AKXV01000039
VERSION     NZ_AKXV01000039.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 99855)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 99855)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 17724
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AKXV01000039.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..17724
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..17724
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17724
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5519:7724](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5520..7724)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            complement(89..1027)
                     /gene="cysD"
                     /locus_tag="Y19_RS0111435"
     CDS             complement(89..1027)
                     /EC_number="2.7.7.4"
                     /GO_function="GO:0004781 - sulfate adenylyltransferase
                     (ATP) activity [Evidence IEA]"
                     /GO_process="GO:0000103 - sulfate assimilation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cysD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237898.1"
                     /locus_tag="Y19_RS0111435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfate adenylyltransferase subunit CysD"
                     /protein_id="WP_017237898.1"
                     /transl_table=11
                     /translation="MTTATRRPTEASENPFALSHLDALEAESVHIFREVAGEFERPVIL
                     FSGGKDSIVMLHLALKAFAPAPVPFALLHVDTGHNFPEVLAYRDRVVAEHGLRLHVASV
                     QEFIDAGRLRERPDGTRNPLQTVPLLDAIESHRFDAVFGGGRRDEEKARAKERVFSLRD
                     EFGAWDPRRQRPELWALYNGRHAPGEHVRVFPLSNWTELDVWQYVEREGIELPAIYYAH
                     EREVFARDGMWLTAGEWGGPKDTERVEKRLIRYRTVGDMSCTGAVDSGAATNADIIAEI
                     AASRLTERGATRADDKLSEAAMEDRKREGYF"
     gene            complement(1024..1611)
                     /gene="cysC"
                     /locus_tag="Y19_RS0111440"
     CDS             complement(1024..1611)
                     /EC_number="2.7.1.25"
                     /GO_function="GO:0004020 - adenylylsulfate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006790 - sulfur compound metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cysC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014135127.1"
                     /locus_tag="Y19_RS0111440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenylyl-sulfate kinase"
                     /protein_id="WP_017237899.1"
                     /transl_table=11
                     /translation="MTTAHAQEATGDTAAAARARGATVWLTGLPSSGKTTLALALAGRL
                     RAEGHEVEVLDGDEIRSYLSRGLGFTREDRHTNVTRIGFVAELLASHGVKVLVPVIAPY
                     ADSRAAVRARHTARGTELLEVHVATPVELCSARDVKGLYARQAAGEISGLTGVDDPYEA
                     PEHPELRIRTQGRSVAASAAELYTFLTERGLA"
     gene            complement(1764..2540)
                     /locus_tag="Y19_RS0111445"
     CDS             complement(1764..2540)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-116). E-value:
                     6.1e-10. Score: 31.0. Matches aSDomain:
                     nrpspksdomains_Y19_RS0111445_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007387476.1"
                     /locus_tag="Y19_RS0111445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_017237900.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.1e-16, bitscore:
                     53.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKVVSRDGTTIAYEKAGEGPPIVLLNGSFRDHTIFDALVPELAP
                     HCTTYVYDRRGRGQSGDAPEYAVEREVEDLEAVIQEAGGEAVVFAGSSGANLAIEAALA
                     GAPITKLALHEPFFRTEGFPKPVWNFAKTLRVLLTEDRRDEAVEHFLGGFLGFTPDTIA
                     EWRKGPIWAMNEANAHTLAYDTLICGDYTVPVDRLATYETETLVLNSDSTSAWLKAAAR
                     ATTAALPNGRGLELPGSWHRIDMDVLGRTLAGFATA"
     aSDomain        complement(2193..2480)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Y19_RS0111445_Abhydrolase_1.1"
                     /evalue="6.10E-10"
                     /label="Y19_RS0111445_Abhydrolase_1.1"
                     /locus_tag="Y19_RS0111445"
                     /protein_end="116"
                     /protein_start="20"
                     /score="31.0"
                     /tool="antismash"
                     /translation="PPIVLLNGSFRDHTIFDALVPELAPHCTTYVYDRRGRGQSGDAPE
                     YAVEREVEDLEAVIQEAGGEAVVFAGSSGANLAIEAALAGAPITKLALHEP"
     gene            complement(2654..3262)
                     /locus_tag="Y19_RS0111450"
     CDS             complement(2654..3262)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004952147.1"
                     /locus_tag="Y19_RS0111450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_017237901.1"
                     /transl_table=11
                     /translation="MIRILLAEDMHMVRGALVALLELEPDLEVVGVVDRGDLIVPTALE
                     CRPDVAVMDVDLPNMDGLTAAETLHDLLPDCRTLIMTGLGRPGLLRRAMAARVSGFLLK
                     DSPAEGLAQAVREVFAGRRVINPQIAMSAWDIGENPLSERETEVLGMAAQGDEPSEIAA
                     KLHLSIGTVRNYLTTTVMKLNARNRLDAVRIATEAGWLS"
     misc_feature    3248..3261
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.68"
                     /tool="antismash"
     misc_feature    3327..3340
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            complement(3333..5306)
                     /locus_tag="Y19_RS41580"
     CDS             complement(3333..5306)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="Y19_RS41580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="WP_017237902.1"
                     /transl_table=11
                     /translation="MLDAPQSEDDPHDACGVQASRMALQVTLGTLAGHTVVTVLAVRDE
                     NPGPARLALLALSMAAVLALQYAHSTRRPRDWPVRTRALTLSAQAVVTFLPLVWLGMPW
                     GAMGGLLAGSILLVVPGRLRWPLYASVIAAIVAAVVAIAGPDKAAYGLGATLLASLIIY
                     GVSSLSDLVTELRDTRRELAGMAVIQERLRVAHDLHDLLGYSLSAIALKSELGYRLLPT
                     APDRARSEVAEVLGIAGEALADVRVVATGYRDMSLADEAESALSVLTAAQIEAEADLTC
                     GPLPREVDTVLAIVLREAVTNALRHSKAQHCAITATREGGTVSLRIRNDGVGETSPDTL
                     PEGGSGLGNLTTRLRGIGGDLSGGPAEDGWFEVVARTPVVPRPEERRAEPEPEEQRKAA
                     RPWAPRMARAMLLAVLAGYTLITVINVAATAPSGAAFLAFLGCLSVVVTVQVLLSLRPP
                     HTWPGYARGIGLGVLAAATYAPLLWLGGPWGSMVGFLAGSFLFTVGGRLRWVLYTASVA
                     VVIPVGAAAGDSLYEIVYETDSSLMAGLAVYAFTALYRLVSELHEARGALVRMAVARER
                     LIVERELHQVLGSSLSEVTMKCALIHRMLPRSPGPAQDELTTVLDISRQALADVRLVAR
                     GYRGQPVAHDPSYTLGLSGAAN"
     misc_feature    complement(5145..5147)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5413..5428
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.2"
                     /tool="antismash"
     misc_feature    complement(5415..5429)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    complement(5416..5431)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.71"
                     /tool="antismash"
     gene            complement(5520..7724)
                     /locus_tag="Y19_RS0111460"
     CDS             complement(5520..7724)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03882"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cyanobactin_D_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Goadsporin_CD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NHLP_CD_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037404.1"
                     /locus_tag="Y19_RS0111460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_017237903.1"
                     /sec_met_domain="Cyanobactin_D_RRE (E-value: 3.6e-14,
                     bitscore: 45.0, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Goadsporin_CD_RRE (E-value: 5e-21,
                     bitscore: 67.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="NHLP_CD_RRE (E-value: 3.1e-17, bitscore:
                     54.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03882 (E-value: 2.4e-46, bitscore:
                     150.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 5.2e-94, bitscore: 307.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.2e-78, bitscore:
                     254.3, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQADERIGFRRHFRAEIVPGEAVYLVSPRGTTALSGAAIQKMAPL
                     LDGSLTLPELRAAVDIPTEQLDGMLGRLASAGLVGFHAERPRDAAAGAYWDLAGVGDPV
                     AAEVTVVAIGGADAEAAERACRAAGLTCGPDAPFALVVCDDYLDPELAVFNAARIADGR
                     PWLPAKPYGAQLCIGPVFRPGDGPCWSCLAVRLRSHRRGESQVRRALGLAGPVRVPEAS
                     LAATRELGLQTAALQAAKWLAGMRDESQNAVWSLDTLTLSASHHPVERRPQCADCGDPG
                     LVADQAMRPVRPVSRPKGVAAGNGHRALSAEEMWERFGHLADPVTGIVERVVRDPRSPS
                     FLHCYQAGPNLAFAGADLSSFRAGLRMQSGGKGRTDLDARVSGLCEAVERYSASRFRDE
                     ATVLGSYRALAPDAVHPAACMLFDERQYRERERWNAPGIPFQYVPERFDEDAEIEWTPV
                     WSLTEGRHRLLPTSQLYFDAEGVGSIVADSNGNAAGGTLEDAILQGFLELVERDAVALW
                     WYNRTRHAGVDLESFGDAWISALPERFSELGRELWVLDLTADLGIPVMAAVSRRVDGPA
                     EEIMLGFGAHLDPAVALSRAVTELGQLLPAVTGGYAKGLPAHLLDWLRGAKVAEQPYLV
                     PDSGLPARTPADYDHVPRADLRDDLEHLCSLAREHGLEVLVLDQTRPDLGLPVVKVVIP
                     GMRHFWARFAPGRLFDVPVRLGRLNSPTAYEDLNPVPLFL"
     aSDomain        complement(7425..7709)
                     /aSDomain="Goadsporin_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     goadsporin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_Y19_RS0111460_Goadsporin_CD_RRE.1"
                     /evalue="1.80E-21"
                     /identifier="RREFam013.1"
                     /label="Y19_RS0111460"
                     /locus_tag="Y19_RS0111460"
                     /protein_end="100"
                     /protein_start="5"
                     /score="67.1"
                     /tool="antismash"
                     /translation="RIGFRRHFRAEIVPGEAVYLVSPRGTTALSGAAIQKMAPLLDGSL
                     TLPELRAAVDIPTEQLDGMLGRLASAGLVGFHAERPRDAAAGAYWDLAGV"
     aSDomain        complement(7437..7709)
                     /aSDomain="NHLP_CD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing CD fusion protein in a
                     NHLP/Nif11 LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_Y19_RS0111460_NHLP_CD_RRE.1"
                     /evalue="1.10E-17"
                     /identifier="RREFam015.1"
                     /label="Y19_RS0111460"
                     /locus_tag="Y19_RS0111460"
                     /protein_end="96"
                     /protein_start="5"
                     /score="54.8"
                     /tool="antismash"
                     /translation="RIGFRRHFRAEIVPGEAVYLVSPRGTTALSGAAIQKMAPLLDGSL
                     TLPELRAAVDIPTEQLDGMLGRLASAGLVGFHAERPRDAAAGAYWD"
     aSDomain        complement(7488..7712)
                     /aSDomain="Cyanobactin_D_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing D protein in a cyanobactin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_Y19_RS0111460_Cyanobactin_D_RRE.1"
                     /evalue="1.30E-14"
                     /identifier="RREFam007.1"
                     /label="Y19_RS0111460"
                     /locus_tag="Y19_RS0111460"
                     /protein_end="79"
                     /protein_start="4"
                     /score="45.0"
                     /tool="antismash"
                     /translation="ERIGFRRHFRAEIVPGEAVYLVSPRGTTALSGAAIQKMAPLLDGS
                     LTLPELRAAVDIPTEQLDGMLGRLASAGLV"
     misc_feature    complement(8034..8048)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     misc_feature    complement(8055..8069)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.37"
                     /tool="antismash"
     gene            8064..8948
                     /locus_tag="Y19_RS38430"
     CDS             8064..8948
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018555420.1"
                     /locus_tag="Y19_RS38430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_017237905.1"
                     /transl_table=11
                     /translation="MSEGPTRFDPVNAGQQPGPLSIGLLGSLSLHLDRTPVTASAPKQR
                     QVLALLALNAGRVVTVPALIEELWGDRPPRSHATTLQTYVLQLRNALAAADSGRPGVRQ
                     ILGTCHSGYLLEDGACTTDVEVFERHVRAGRNASEAGDHRRASEELRQALQLWRGPALV
                     DVRKGSVLEIEAVSLEESRLGALERRIESDLALGRHADLLGELTRVVARNPMNENLCAY
                     LMIALYRAGRVGRSLEAFHRLRSVLNHELGVEPCPRLQGLQTAILSGDPALDVWSVSWS
                     PEEFAANRLARAS"
     gene            complement(9041..10549)
                     /locus_tag="Y19_RS0111475"
     CDS             complement(9041..10549)
                     /NRPS_PKS="Domain: AMP-binding (8-405). E-value: 1.1e-112.
                     Score: 368.6. Matches aSDomain:
                     nrpspksdomains_Y19_RS0111475_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308517.1"
                     /locus_tag="Y19_RS0111475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_017237906.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-120, bitscore:
                     394.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNLALNLARTAAARPDSTAILLDDQALDYRALDGRSALVAGWLA
                     ARGVGPGDRVAILLPNIPHFAVAYYGVLRAGAVAVPMNPLLKSGEIGYGAGDCGAKLIL
                     AWGAAMAEAGAAAAELGIGCVDVTDPGFGAELAAAEPRGEVVERDDDDLAVLLYTSGTT
                     GRPKGARLTHGNLGSNTAAVARVLGMSASDTVFGGLPFFHVFGQTCGLNAAVLTGARIT
                     LLPRFDAAKALEILSRDRVTVMEGVPTMFLGLLAAAEAAGSTGLTGEEGLRLCVTGGSA
                     MPVEVLYRFESAFGCPVVEGYGLSETSPVVTFGSLDGPRKPGSIGTPIEGVRVRLVDDE
                     GKEVPEGDVGEIAVNGPNVMAGYWNRPDADAAAFADGWFRTGDLARRDEDGFYFIVDRK
                     KDLVIRGGYNVYPREIEEVFYEHPAVAEAAVVGVPHEVHGEEVAAVVTLKPGAEVTADE
                     LRAFVKARVAPYKYPRIVRLVPGLPKGPTGKILKREITVEGPAE"
     CDS_motif       complement(9302..9364)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0111475_0004"
                     /evalue="1.40E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="Y19_RS0111475"
                     /protein_end="416"
                     /protein_start="395"
                     /score="11.5"
                     /tool="antismash"
                     /translation="VDRKKDLVIRGGYNVYPREIE"
     aSDomain        complement(9335..10525)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Y19_RS0111475_AMP-binding.1"
                     /evalue="1.10E-112"
                     /label="Y19_RS0111475_AMP-binding.1"
                     /locus_tag="Y19_RS0111475"
                     /protein_end="405"
                     /protein_start="8"
                     /score="368.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ARTAAARPDSTAILLDDQALDYRALDGRSALVAGWLAARGVGPGD
                     RVAILLPNIPHFAVAYYGVLRAGAVAVPMNPLLKSGEIGYGAGDCGAKLILAWGAAMAE
                     AGAAAAELGIGCVDVTDPGFGAELAAAEPRGEVVERDDDDLAVLLYTSGTTGRPKGARL
                     THGNLGSNTAAVARVLGMSASDTVFGGLPFFHVFGQTCGLNAAVLTGARITLLPRFDAA
                     KALEILSRDRVTVMEGVPTMFLGLLAAAEAAGSTGLTGEEGLRLCVTGGSAMPVEVLYR
                     FESAFGCPVVEGYGLSETSPVVTFGSLDGPRKPGSIGTPIEGVRVRLVDDEGKEVPEGD
                     VGEIAVNGPNVMAGYWNRPDADAAAFADGWFRTGDLARRDEDGFYFIVDRKKDLVIR"
     CDS_motif       complement(9428..9517)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0111475_0003"
                     /evalue="3.70E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="Y19_RS0111475"
                     /protein_end="374"
                     /protein_start="344"
                     /score="32.1"
                     /tool="antismash"
                     /translation="PEGDVGEIAVNGPNVMAGYWNRPDADAAAF"
     CDS_motif       complement(10031..10090)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0111475_0002"
                     /evalue="3.50E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="Y19_RS0111475"
                     /protein_end="173"
                     /protein_start="153"
                     /score="22.6"
                     /tool="antismash"
                     /translation="AVLLYTSGTTGRPKGARLTH"
     CDS_motif       complement(10304..10339)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0111475_0001"
                     /evalue="9.80E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="Y19_RS0111475"
                     /protein_end="82"
                     /protein_start="70"
                     /score="9.7"
                     /tool="antismash"
                     /translation="GVLRAGAVAVPM"
     gene            complement(10637..11308)
                     /locus_tag="Y19_RS0111480"
     CDS             complement(10637..11308)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957080.1"
                     /locus_tag="Y19_RS0111480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017237907.1"
                     /transl_table=11
                     /translation="MQKFATTAEIVAVLDIAAGDIRLVAGERDEVAVEVLPADASKGRD
                     VKAAEGVEVAYEEGVLRVGNTAPKNRLFGESGVVGVTVWLPAGSRVEARTAAGELTGVG
                     RLGEVAFEGAQSEVRLEEVAGGRIVLQAGGITVDRLGGDAEFRTQRGDIRVVEATRGAV
                     TLRTEAGTIDVGAARGTSATLDAGTAYGRITNTLGNTEGADAGLRIHAGTSYGDITARG
                     L"
     gene            11665..12477
                     /locus_tag="Y19_RS0111485"
     CDS             11665..12477
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265094.1"
                     /locus_tag="Y19_RS0111485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017237908.1"
                     /transl_table=11
                     /translation="MTRDLVLGEAEDVRRAAEALAEGAAVAHGFGNFYALTARPDREAV
                     ERVNLMKGRPAGQVGSVTTVREGVGALFDWTRLPPALPRRQIEDLVDELLHLGPFGLRG
                     PAAAHVPAHLTAVAHGVDTVQLIVPGYSCPSNAFLAEALARTGAGFLSITSANRSRHLT
                     GADHEPAHWRADGVTADFGHEPGVRVLAHPDEAAARRRHPHHTTTSTTVLSFHHTPGHG
                     RPGMPALTLERHGSLSADHTRAIAANHGFTLTLSPHAHHRLAPRPYSA"
     gene            complement(12533..12949)
                     /locus_tag="Y19_RS0111490"
     CDS             complement(12533..12949)
                     /EC_number="1.20.4.4"
                     /GO_function="GO:0030612 - arsenate reductase (thioredoxin)
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015034664.1"
                     /locus_tag="Y19_RS0111490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arsenate reductase ArsC"
                     /protein_id="WP_017237909.1"
                     /transl_table=11
                     /translation="MTAPLASVLFVCVHNAGRSQMAAGFLSHLAGDRVEVRSAGSIPGD
                     QVNPAAVEAMAEVGVDISDQKPKVLTTEAVQASDYVITMGCGDACPIFPGKKYLDWALE
                     DPAGQGVEAVRPIRDEIKGLIEGLIAEIDAKREA"
     gene            13107..13415
                     /locus_tag="Y19_RS0111495"
     CDS             13107..13415
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975238.1"
                     /locus_tag="Y19_RS0111495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_017237910.1"
                     /transl_table=11
                     /translation="MLTSVDTDLLRVLGDPLRLRIVTLLARETLCTTHLVEETGARQTN
                     LSNHLRVLREAGVVETEPCGRFTYYRLNPDVIEVLAGQFADLAAAARANADTKRACP"
     gene            13450..14220
                     /locus_tag="Y19_RS0111500"
     CDS             13450..14220
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015659441.1"
                     /locus_tag="Y19_RS0111500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MIP/aquaporin family protein"
                     /protein_id="WP_017237911.1"
                     /transl_table=11
                     /translation="MTANEPAASDAIAIDPSPRPAPGATPPRTPLAARAAAELVGTAAL
                     VAIVVGSGIQAADLTDDVALQLLANSTATVFGLGVLIALLGPVSGAHFNPAVTLAEWWT
                     ARRGGAGVNARELAVYVPSQIVGAIAGAVLADAMFGEPLVKWSTHDRSAGNLLLGEVVA
                     TAGLILLIFGLARTDRLRFAPVAVASYIGAAYWFTSSTSFANPAVTIGRAFTDTFAGIA
                     PASVPAFVGMQLIGAAVGLALVAVIFTRGKTDAE"
     gene            14217..15278
                     /locus_tag="Y19_RS0111505"
     CDS             14217..15278
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031223.1"
                     /locus_tag="Y19_RS0111505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ArsO family NAD(P)H-dependent flavin-containing
                     monooxygenase"
                     /protein_id="WP_017237912.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-13, bitscore:
                     43.3, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 2.9e-09, bitscore: 29.2,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQVVDVVVIGGGQSGLAAGYHLRRLGLDFVVLDAQATPGGAWQH
                     TWDSLHLFSPAAYSSLPGRPMPPQPGETYPEAAHVVTYLSDYEQRYELPVVRSVRVEAV
                     HRDGEFLRVEADAGTWRARTVISATGTWRRPFVPAVPGRTDFRGAQLHTVEYRGPRDFA
                     GQRVIVVGGGNSGAQIAADLAYDTDLTWVTLREPRYLADDIDGRALFDHATARRRALDE
                     GRTDTGGVASLGDIVAVPPVREARDAGLLKAQPMFARLTATGVEWADGMTADADAVIWC
                     TGFRPALSHLAPLGLRGPRGRVPTSGTRALGEPRLHLLGYGDWTGAASATLIGVGRPAR
                     EAAREIAGLLGGG"
     gene            complement(15339..15842)
                     /locus_tag="Y19_RS0111510"
     CDS             complement(15339..15842)
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017237913.1"
                     /locus_tag="Y19_RS0111510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_017237913.1"
                     /transl_table=11
                     /translation="MTAAPTVVVPLTAEHADAVVAIYRAGIDEGDATFETTAPTWAEFD
                     AARLSEHRFAAVDETGRVLGWVAASRVSDRCAYAGVVEHSVYVHPDARGRGVASALLKA
                     LVDSTEAAGIWTIQSGIFPENAASLAVHERAGFRVIGTRERIGRHHGRWRDTVLVERRS
                     PHID"
     gene            complement(15839..16201)
                     /locus_tag="Y19_RS0111515"
     CDS             complement(15839..16201)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005473395.1"
                     /locus_tag="Y19_RS0111515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_026057965.1"
                     /transl_table=11
                     /translation="MSNAKVLPLLEPAVEPCCPPLAERPLTAEEAERTAVMFKALGDPV
                     RLRLFSSVASHEGGEACVCDISDVGVSQPTVSHHLKKLKEAGLLSSERRGTWVYYRIEP
                     AVLAAMGALLTKAAAA"
ORIGIN
        1 ccgtcgtcga cggacccggc ggtggcgaag cgcagcagcg aggcggcggg ggcctcctga
       61 gcggcggtca cggcggtggt ggtcacggct agaagtaccc ctcgcgcttg cggtcttcca
      121 tggcggcctc ggagagcttg tcgtcggccc gggtggcgcc gcgctcggtg aggcggctgg
      181 cggcgatctc ggcgatgatg tccgcgttgg tggcggcgcc ggagtcgacg gcgcccgtgc
      241 aggacatgtc gccgaccgtg cggtagcgga tcagccgctt ctcgacccgc tcggtgtcct
      301 tggggccgcc ccactcgccc gcggtcagcc acatcccgtc acgggcgaac acctcgcgct
      361 cgtgcgcgta gtagatcgcc ggaagttcga tgccctcgcg ctcgacgtac tgccagacgt
      421 ccagctcggt ccagttggac agcgggaaga cgcggacgtg ctcgccgggc gcgtggcggc
      481 cgttgtagag cgcccagagc tcggggcgct ggcggcgggg gtcccaggcg ccgaactcgt
      541 cgcgcagcga gaacacccgc tccttggcgc gggccttctc ctcgtcgcgg cggccgccgc
      601 cgaagaccgc gtcgaagcgg tgggactcta tggcgtcgag cagcggcacc gtctgcagcg
      661 ggttgcgcgt cccgtccggg cgctcgcgca gccggcccgc gtcgatgaac tcctggacgg
      721 aggcgacgtg caggcgcagc ccgtgctcgg ccaccacccg gtcgcggtag gcgaggacct
      781 cggggaagtt gtgccccgtg tccacgtgca gcagcgcgaa cggcaccggc gcgggcgcga
      841 aggccttcag cgccaggtgc agcatgacga tcgagtcctt gccgccggag aagaggatca
      901 ccggccgctc gaactcaccc gccacctcac ggaagatgtg caccgactcc gcctccaggg
      961 cgtccaggtg cgacagcgcg aacgggttct ccgacgcctc ggtcggacgc cgggtcgcgg
     1021 tcgtcatgcc aggcccctct cggtcaggaa ggtgtacagc tcggcggcgg acgcggccac
     1081 cgaccggccc tgcgtccgga tgcgcagctc cgggtgctcc ggtgcctcgt acgggtcgtc
     1141 cacgccggtg agaccggaga tctcgccggc ggcctgccgg gcgtacaggc ccttcacgtc
     1201 ccgcgccgag cagagctcga cgggggtggc cacgtgcacc tccaggagct ccgtgccgcg
     1261 ggcggtgtgc cgcgcgcgga cggcggcgcg ggagtcggcg tacggcgcga tgaccggcac
     1321 cagcaccttc acgccgtgcg aggcgagcag ttcggccacg aagccgatcc gggtgacgtt
     1381 ggtgtgccgg tcctcccggg tgaacccgag ccccctggac aggtaggagc ggatctcgtc
     1441 accgtcgagc acctcgacct cgtggccctc ggcgcgcagc cgtccggcga gggcgagggc
     1501 gagggtggtc ttgcccgagc tgggcagccc ggtcagccac acggtggcac cgcgggcacg
     1561 ggccgcggcc gcggtgtccc cggtggcctc ctgggcgtga gctgtggtca cggcgatgtt
     1621 ctccccgaaa gtgaggtggc ggcgggggct cccgggcgcg cctcgcccgc ggacgtgtgg
     1681 cccgggcgcg aggggcggcg ggaacccccg gaaggtcgcg gtagccctcg ggcggcggaa
     1741 cccccggaag gtggcggtgg ccctcaggcg gtggcgaacc cggccagggt ccggccgagc
     1801 acgtccatgt cgatccggtg ccaggagccg ggcagttcga gcccccggcc gttgggcagg
     1861 gccgccgtcg tcgcccgcgc cgccgccttc agccaggcgc tggtgctgtc gctgttgagg
     1921 acgagggtct ccgtctcgta ggtcgcgagc cggtcgaccg ggacggtgta gtcgccgcag
     1981 atcagggtgt cgtacgcgag ggtgtgggcg ttcgcctcgt tcatcgccca gatcgggccc
     2041 ttgcgccact cggcgatggt gtcgggcgtg aagcccagga agccgccgag gaagtgctcg
     2101 accgcctcgt cgcgccggtc ctcggtgagc aggacccgga gcgtcttcgc gaagttccac
     2161 acgggcttcg ggaagccctc ggtccggaag aagggctcgt gcagggcgag tttcgtgatc
     2221 ggggcaccgg cgagcgccgc ctcgatcgcg aggttcgcgc cggaggaccc ggcgaacacc
     2281 accgcctcgc cgccggcctc ctggatcacc gcctccaggt cctctacctc ccgctcgacc
     2341 gcgtactcgg gcgcgtcgcc gctctggccg cgcccccggc ggtcgtagac gtacgtcgtg
     2401 cagtgcggcg ccagttcggg cacgagggcg tcgaagatcg tgtgatcgcg gaacgacccg
     2461 ttgagaagca cgatgggcgg gccttcgccc gccttctcgt aggcgatcgt cgtgccgtcc
     2521 cgggaaacga ccttgcgcat ctcgcactcc tcatgccgac cggaggtgct ctcacctcgc
     2581 cgtatgtcgg catcttcgag cgcgtcgctg gatcaccggt cgaggaccgg tcgcgggtgg
     2641 tggcccgcct ccgtcaggac agccagccgg cctcggtggc gatgcgtacg gcgtcgagcc
     2701 ggttgcgcgc gttcagcttc atcacggtcg tcgtcaggta gttgcgtacc gtcccgatcg
     2761 aaagatgcag tttggcggcg atctcgctgg gctcgtcgcc ctgggcggcc atccccagga
     2821 cctcggtctc gcgctcggac agggggttct cgccgatgtc ccacgcgctc atggcgatct
     2881 gcgggttgat caccctgcga cccgcgaaca cctcccggac cgcctgcgcg agcccttcgg
     2941 ccggggagtc cttgagcagg aaccccgaga cgcgcgcggc catcgcccgc cgcagcagac
     3001 ccgggcgtcc gagtccggtc atgatgagcg tccggcagtc cggaagcagg tcgtgcagcg
     3061 tctccgcagc cgtgagcccg tccatgttcg gcaggtcgac gtccatgacg gccacgtccg
     3121 gccggcactc cagcgcggtg gggacgatca ggtcgccccg atccaccacg ccgacgacct
     3181 ccaggtcggg ctccagttcg agcagcgcga ccagcgctcc tctgaccatg tgcatgtcct
     3241 cggcgaggag aattctgatc acccgattct ccacttgtcc cccttttacc ttccttgaag
     3301 gtatgtaatg cgccttaacc tacctgcgaa cctcagttcg cggcccccga aagtccgagc
     3361 gtgtacgacg gatcgtgtgc gaccggttgt ccccggtacc cccgcgccac gagccgcacg
     3421 tccgcgagtg cctggcgcga gatgtcgaga acggtcgtca gctcgtcctg cgcgggcccc
     3481 ggcgaccggg gcagcatccg gtggatgagc gcgcatttca tggtgacctc ggagaggctc
     3541 gacccgagca cctggtgcag ctcgcgctcc acgatcaggc gctcgcgggc gaccgccatc
     3601 cgcaccagcg cccccctggc ctcgtggagt tcggagacca gccggtagag cgcggtgaag
     3661 gcgtacacgg ccaggcccgc catcagcgag gagtcggtct cgtagacgat ctcgtagagc
     3721 gagtcgcccg ccgccgcccc caccgggatc acgacggcga ccgaggccgt gtagagcacc
     3781 caccggagcc tcccgcccac ggtgaagagg aacgatccgg cgaggaaccc gaccatcgag
     3841 ccccacggcc cgccgagcca gagcagcggg gcgtacgtgg ccgccgccag caccccgagg
     3901 ccgatgcccc gcgcgtaccc cggccatgtg tgcggggggc gcagcgagag cagcacctgc
     3961 acggtcacga cgaccgagag gcagccgagg aacgcgagga aggcggcccc ggacggggcg
     4021 gtggccgcca cgttgatcac cgtgatgagc gtgtagccgg ccaggacggc caggagcatg
     4081 gcccgcgcca tcctcggcgc ccagggccgg gcggccttcc gctgctcctc gggctcgggc
     4141 tccgcgcggc gctcctcggg ccggggcacg accggtgtcc gggcgaccac ctcgaaccag
     4201 ccgtcctcgg ccgggccgcc gctcaggtcg ccgccgatgc cgcgcagccg ggtcgtcagg
     4261 ttgccgagcc cgctgccgcc ctccgggagg gtgtcgggac tggtctcgcc caccccgtcg
     4321 ttgcggatcc gcagcgagac cgtcccgccc tcgcgggtcg cggtgatcgc gcagtgctgc
     4381 gccttgctgt ggcgcagggc gttggtgacg gcctcgcgca gcacgatggc caggacggtg
     4441 tccacctcgc gcggcagcgg cccgcaggtg aggtcggcct ccgcctcgat ctgcgcggcg
     4501 gtcagcaccg agagcgcgga ctcggcctcg tcggccaggg acatgtcgcg gtagccggtg
     4561 gcgacgaccc gtacgtcggc gagcgcctcg ccggcgatgc cgagcacctc ggcgacctcg
     4621 gacctggccc ggtcgggtgc cgtcgggagc agccggtatc cgagttcgct cttcagggcg
     4681 atcgccgaca ggctgtagcc gagcaggtcg tgcaggtcgt gggcgacccg cagccgctcc
     4741 tggatgacgg ccatgccggc cagctcgcgc ctggtgtcgc gcagttcggt gacgaggtcg
     4801 gagagggagc tgaccccgta gatgatgagg ctggcgagca gcgtggcgcc gagtccgtag
     4861 gcggccttgt cgggtccggc gatcgcgacg accgcggcca cgatggcggc gatgacggag
     4921 gcgtacagcg gccagcggag ccggccggga acgacgagga ggatcgagcc cgcgagcagt
     4981 ccgcccatcg cgccccacgg catcccgagc cagacgagcg ggaggaaggt gaccacggcc
     5041 tgcgcggaca gcgtcagcgc acgggtgcgg acgggccagt cgcgcggtct tcgggtggag
     5101 tgggcgtact gcagggcgag gacggccgcc atgctgaggg cgagtaacgc gagccgcgcg
     5161 ggtccggggt tctcgtcgcg tacggccagc acggtgacga ccgtgtggcc ggcgagcgtg
     5221 cccagcgtga cctggagggc catgcgtgat gcctgcaccc cacacgcgtc gtgcggatcg
     5281 tcctcgctct ggggtgcgtc gagcatcagc gcgcgcctcc tagtccgacc agcggtggac
     5341 gagagcacag gcgaccgccc gagtaccccc ctgaataccg ccggtgatca tacctgggaa
     5401 gtaacggctt gtcatgagca caattttcac ttttccgact tcttcgacgg ggctcgaccg
     5461 ccaccagcgg tgatgccccc ggcctccttt ccgggccttt cgaccccccg cggggtccct
     5521 cagaggaaca gcggaaccgg gttcaggtcc tcgtacgccg taggggagtt cagccttccg
     5581 agccgcaccg gcacgtcgaa caggcggccc ggcgcgaacc tcgcccagaa gtgccgcatg
     5641 cccgggatga cgaccttcac caccggcagc ccgagatcgg gccgcgtctg gtcgagcacc
     5701 aacacctcca gaccgtgctc gcgggccagc gagcagaggt gctccaggtc gtcccgcagg
     5761 tcggcgcgcg gcacgtggtc gtagtccgcg ggcgtccgcg ccggaagacc ggagtccggt
     5821 acgagatagg gctgttcggc gaccttcgcc ccccgcagcc agtcgagcag gtgcgccggc
     5881 agccccttcg cgtagccgcc cgtcacggcc ggcagcaact gccccagctc ggtgacggcg
     5941 cggctcagcg cgacggccgg atccaggtgt gcgccgaagc cgagcatgat ctcctcggcc
     6001 ggcccgtcga cccgccgcga caccgccgcc atcaccggaa tccccaggtc ggcggtgagg
     6061 tcgagcaccc agagctcacg ccccaactcg ctgaatcgtt ccggcagagc ggagatccac
     6121 gcgtcgccga acgactccag gtccaccccc gcgtgccgcg tccggttgta ccaccacagc
     6181 gccaccgcgt cccgctccac cagctccagg aacccctgca ggatcgcgtc ctccagcgtg
     6241 ccgccggccg cgttcccgtt cgagtcggcg acgatcgaac cgaccccctc ggcgtcgaag
     6301 tacaactggc tcgtcggcag cagccggtgc cggccctcgg tgagcgacca cacgggcgtc
     6361 cactcgatct cggcgtcctc gtcgaaccgc tccggcacgt actggaaggg aatccccggc
     6421 gcgttccacc gctcccgctc ccggtactgc cgctcgtcga acagcatgca cgccgccgga
     6481 tgcaccgcgt ccggcgccag cgcccggtaa ctgcccagca ccgtcgcctc gtcacggaac
     6541 cgcgacgcgc tgtaccgctc gaccgcctcg cacaacccgc tgacccgcgc gtccagatcc
     6601 gtgcgcccct tgcccccgct ctgcatccgc agccccgcgc ggaacgacga caggtccgca
     6661 ccggcgaacg ccaggttcgg ccccgcctgg tagcagtgca ggaacgacgg gctgcgcgga
     6721 tcacggacga cccgctccac gatccccgtc accggatccg ccaggtgccc gaaccgctcc
     6781 cacatctcct ccgccgacag cgcccggtgc ccgttgcccg cggcgacgcc cttcggccgc
     6841 gagaccggcc gcaccggccg catcgcctgg tcggcgacca gcccgggatc tccgcagtcc
     6901 gcgcactgcg gcctgcgctc caccggatgg tgcgaggcgc tcagcgtcag ggtgtccagc
     6961 gaccacaccg cgttctgact ctcgtcgcgc atcccggcca gccacttcgc cgcctgcagc
     7021 gccgccgtct gcaaccccag ctcacgcgtg gccgccaacg acgcctccgg cacccgcacc
     7081 ggccccgcca gacccagcgc gcgccgcacc tgcgactcgc cgcgccggtg cgagcggagc
     7141 cgtaccgcca gacaggacca gcagggcccg tcgcccggcc ggaagaccgg gccgatgcac
     7201 agctgcgccc cgtagggctt ggccggcagc cacggccggc cgtccgcgat ccgggcggcg
     7261 ttgaacacgg ccagctccgg atcgaggtag tcgtcacaga cgaccagcgc gaagggcgcg
     7321 tcggggccgc acgtcagtcc cgccgcacgg caggcgcgtt ccgcagcctc cgcgtcggcg
     7381 ccgccgatcg ccacgacggt cacctcggcc gccaccgggt cgcccacacc ggcgaggtcc
     7441 cagtacgccc cggccgccgc gtcccgcggt cgctccgcgt ggaaaccgac gagacccgcg
     7501 gaggcgagcc ggccgagcat gccgtccagc tgctcggtgg ggatgtccac ggccgcccgc
     7561 agctcgggaa gggtcagcga gccgtcgagc agcggggcca tcttctggat cgcggcaccg
     7621 gagagggccg tggtgccccg cggggagacg aggtagaccg cctcgcccgg gacgatctcg
     7681 gcgcggaagt ggcgccggaa acctatccgt tcgtcagcct gcacggtgcg ccgctctatc
     7741 gcgccacgtc gacgggcagg gagtaacacc agggagtggg gttctccccg tcggaggggg
     7801 agccgtccag gttctcgatg atcaggtcgt cgaagccggg agtggtctgc atgacgtcgc
     7861 ctctctcttc cgcctgccgc agccggttcg tcgctgcggt gccccgaagt caacagcgac
     7921 cccggcgaag gccgccatgc gccgattcac gttccccatg tgaattcttc atatgggaga
     7981 gatgtgcagc tcagtgggca actccggcag ctctcggcat gctggagacc gagatcgata
     8041 ggtgcgatgc ctggaggaac gcaatgtccg aaggtcctac aaggttcgac cccgtcaacg
     8101 ccggtcagca gcccggaccg ctgagcatcg gactgctcgg ctcgctgtcc ctgcatctcg
     8161 accggacccc ggtgacggcg agcgccccca agcagcggca ggtgctggcg ctcctcgccc
     8221 tgaacgcggg ccgcgtcgtg accgtaccgg cgctcatcga ggaactgtgg ggagaccgcc
     8281 ccccgcgcag ccacgccacc accctgcaga cgtacgtgct ccagctccgc aacgcgctcg
     8341 cggcggccga ctccggccgc cccggcgtgc gccagatact cggcacctgc cacagcggct
     8401 acctcctcga ggacggcgcc tgtacgacgg acgtggaggt cttcgagcgc cacgtgcgcg
     8461 ccggccgcaa cgcctccgag gccggcgacc accgccgcgc ctccgaagag ctgcgccagg
     8521 cactgcagtt gtggcgcggg cccgccctcg tcgacgtccg caagggcagc gtcctggaga
     8581 tcgaggcggt gtccctggag gagagccggc tcggcgccct cgaacgccgc atcgagtccg
     8641 acctcgccct cggccgccac gccgacctgc tcggcgagct gacccgggtc gtcgcccgga
     8701 accccatgaa cgagaacctc tgcgcctacc tgatgatcgc cctctaccgc gcgggccgcg
     8761 tcggacgctc cctggaggcc ttccaccgcc tccgctccgt gctcaaccac gagctgggcg
     8821 tcgaaccctg cccccgcctc cagggcctcc agacggccat cctctccggc gacccggccc
     8881 tcgacgtctg gtccgtctcc tggtcccccg aggagttcgc cgccaaccgc ctcgcccgcg
     8941 cctcctgaac ccccaccacg cgggaacctc cccacccgca ggagccgttc ccccggcaca
     9001 cggctcctgg tgggggcggg ggacggccga cgcgctcccg ctactccgcc gggccctcga
     9061 ccgtgatctc ccgcttcagg atcttgcccg tcggtccctt gggcagcccc ggcaccagcc
     9121 ggacgatccg cgggtacttg tacggcgcca cccgggcctt cacgaacgcg cgcagttcgt
     9181 ccgccgtgac ctccgcaccc ggcttcaggg tgacgacggc cgcgacctcc tcgccgtgca
     9241 cctcgtgcgg gacgcccacc acggccgcct cggcgaccgc cgggtgctcg tagaagacct
     9301 cctcgatctc gcgcgggtag acgttgtacc caccgcggat caccaggtcc ttcttgcggt
     9361 ccacgatgaa gtagaagccg tcctcgtcgc gccgggcgag atccccggtg cggaaccagc
     9421 cgtcggcgaa cgccgccgcg tcggcgtcgg gacggttcca gtaaccggcc atgacgttcg
     9481 gcccgttgac ggcgatctcg ccgacgtcgc cctccgggac ctccttgccc tcgtcgtcga
     9541 ccagccggac ccgcacgccc tcgatcgggg tcccgatcga ccccggcttg cggggcccgt
     9601 ccagcgaccc gaaggtgacg acgggggagg tctccgacag cccgtacccc tcgacgacag
     9661 gacacccgaa ggcggactcg aagcggtaca gcacctccac cggcatcgcg gaaccgccgg
     9721 tcacacagag ccgcagcccc tcctcgcccg tcagcccggt ggaacccgcc gcctcggcgg
     9781 cggcgagcag acccaggaac atcgtgggca ccccctccat caccgtgacc cggtcccggg
     9841 agaggatctc cagcgccttc gcggcgtcga agcgcggcag cagcgtgatc cgcgcgcccg
     9901 tcaggaccgc cgcgttcagg ccgcaggtct ggccgaacac gtggaagaac ggcagcccgc
     9961 cgaagaccgt gtccgacgcc gacatcccga gcacccgcgc cacggccgcc gtgttggagc
    10021 ccaggttccc gtgggtgagc cgggccccct tgggccggcc ggtggtgccc gacgtgtaca
    10081 gcagcaccgc gaggtcgtcg tcgtcccgct ccacgacctc cccgcgcggc tcggccgcgg
    10141 ccagctcggc cccgaagccc gggtccgtca cgtcgacgca cccgatgccg agctccgccg
    10201 ccgcggcgcc cgcctcggcc atggcggcac cccacgccag gatcagcttc gccccgcagt
    10261 cgcccgcgcc gtagccgatc tcccccgact tcagcagcgg gttcatcggc accgcgaccg
    10321 ccccggcccg cagcacgccg tagtaggcga ccgcgaagtg cgggatgttc ggcagcagga
    10381 tcgccacccg gtcaccgggc ccgactcccc gcgccgccag ccaccccgcg accagcgcgc
    10441 tgcgcccgtc cagcgcccgg tagtcgagcg cctggtcgtc cagcaggatc gccgtactgt
    10501 ccggccgtgc cgccgcggta cgagccagat tgagggccag attggtcacc gtcgacctct
    10561 ttccgatggt tcggctttgc tcccgggcag gctatcggcc gccctcggga cgccgtcggc
    10621 agcccgccgc cgcagctcag aggccgcgcg cggtgatgtc gccgtacgac gtgccggcgt
    10681 ggatccgcag gccggcgtcg gcgccctcgg tgttgccgag ggtgttggtg atccgcccgt
    10741 aggcggtgcc ggcgtccagc gtcgcggagg tgccgcgggc ggcaccgacg tcgatcgtcc
    10801 cggcctcggt gcgcagcgtg accgcgcccc gcgtcgcctc gacgacgcgg atgtcgcccc
    10861 gctgcgtgcg gaactccgcg tcgccgccca gccggtccac cgtgatcccg cccgcctgca
    10921 gcacgatccg gccccccgcg acctcttcga ggcggacctc gctctgcgcc ccctcgaacg
    10981 cgacctcccc cagccgtccg acgcccgtca gctcccccgc cgccgtcctg gcctccaccc
    11041 gcgacccggc cggcagccac accgtgaccc cgacgacccc ggactccccg aacagccggt
    11101 tcttcggcgc cgtgttcccg acccgcagga caccctcctc gtacgcgacc tcgaccccct
    11161 cggccgcctt cacgtcccgc cccttcgacg cgtcggccgg caggacctcg acggcgacct
    11221 cgtcccgctc cccggcgacg agccggatgt ccccggcggc gatgtccagg acggcgacga
    11281 tctcggcggt ggtggcgaac ttctgcatgg ccttctcctt ctccagcggt gggctctcgt
    11341 cgacccgtcg tttccgatga gggaaaagct acgttgcgtt cgcgctagtg gcaacagctc
    11401 tccccttcga aatggccata ttcgcaggtc agtccagaga tttcattgca acgacttacg
    11461 aactaacgca acgccagata tggaatccat tgcaatggac tgaaggtgaa cgctcctcgg
    11521 gccggccgga cccgagcgac cggccggtga ccgatggtga ccaatggtga ccggcggtgg
    11581 tcgagatcgt tgcccggtca tcaacgaata cagccgatac gggcgtaaag ccggaggtgt
    11641 gcggtgggcg gacaagcggc gagcatgacg cgggacctgg tcctgggcga ggccgaggac
    11701 gtgcggcggg cggccgaagc actggccgaa ggggccgcgg tggcccacgg gttcggcaac
    11761 ttctacgccc tgacggcgcg ccccgaccgg gaggccgtcg agcgcgtgaa cctgatgaag
    11821 ggccgccccg ccggccaggt cggcagcgtc accaccgtcc gcgaaggggt cggggcgctc
    11881 ttcgactgga cgcggctccc gcccgcgctc ccgcgccgcc agatcgagga cctcgtcgac
    11941 gaactgctcc acctcggccc gttcggcctg cggggcccgg cggccgcgca cgtcccggcc
    12001 catctgacgg cggtcgcgca cggcgtcgac accgtgcagc tgatcgtccc cggctactcc
    12061 tgcccgtcca acgcgttcct cgccgaggcg ctggcccgta ccggcgccgg attcctctcg
    12121 atcacctcgg cgaaccgctc acgccacctg acgggcgcgg accacgaacc cgcccactgg
    12181 cgcgccgacg gcgtcaccgc cgacttcggc cacgagcccg gcgtccgcgt cctcgcccac
    12241 cccgacgagg ccgccgcccg ccgccgccac ccccaccaca ccacgacctc caccaccgtc
    12301 ctctccttcc accacacccc cggccacggc cgccccggca tgcccgcgct caccctcgaa
    12361 cgccacggct ccctctccgc cgaccacacc cgcgccatcg ccgccaacca cggcttcacc
    12421 ctcaccctct ccccccacgc ccaccaccgc ctcgcccccc gcccctactc cgcctgagtc
    12481 ccggcccgcc gcttcagcgg cggcgggccg ggaacgggcg cggtcgtcga ggtcacgcct
    12541 cccgcttcgc gtcgatctcg gcgatgaggc cctcgatgag gcccttgatc tcgtcacgga
    12601 tggggcggac ggcctcgacg ccctggccgg ccgggtcctc cagggcccag tccaggtact
    12661 tcttgccggg gaagatcggg caggcgtcgc cacagcccat ggtgatgacg tagtccgacg
    12721 cctggaccgc ctcggtcgtc aggaccttcg gcttctggtc ggagatgtcg acgccgacct
    12781 cggccatggc ctcgacggcg gccgggttga cctggtcgcc cggaatcgaa cccgcggagc
    12841 ggacctcgac gcggtctccg gcgaggtggc tgaggaaccc ggcggccatc tgggagcggc
    12901 cggcgttgtg gacgcagacg aagaggacgg aggcgagcgg agcggtcatc ggttcttcct
    12961 caggggtgga ggtgggggcg ggggtaggcg cggagggcgc gggaaagggc cgggtgtcag
    13021 ggcgcggtca cggcgggaat cccgcgagag cgaacgaggt cggcccaggc tggtatcagc
    13081 cccgggtgat gtgaaaatat cagcccatgc tgacgtcagt cgatactgat ctgctccggg
    13141 tgctgggcga ccccctgcgc ctccggatcg tgaccctgct cgcccgcgag acgctgtgca
    13201 ccacccacct ggtcgaggag acgggcgccc ggcagaccaa cctctcgaac cacctgagag
    13261 tgctgcgcga ggcgggggtc gtggagacgg agccctgcgg ccggttcacc tactaccggc
    13321 tcaacccgga cgtcatcgag gtcctggccg ggcagttcgc cgacctggcc gcagccgccc
    13381 gcgccaacgc cgacaccaag agagcctgcc cgtaagcctc tcgccccacc tgccgaggag
    13441 tacccgcccg tgaccgccaa cgagcccgcc gcgagcgacg ccatagccat cgacccgtcg
    13501 ccgcggcccg cgcccggcgc caccccgccc cgtaccccgc tcgccgcccg ggccgccgcc
    13561 gagctcgtcg gcaccgccgc gctcgtggcg atcgtcgtcg gctccggcat ccaggccgcc
    13621 gacctcaccg acgacgtggc cttgcagctc ctcgccaact ccaccgccac cgtcttcggc
    13681 ctcggcgtcc tcatcgcgct cctcggcccc gtctccggcg cgcacttcaa cccggccgtc
    13741 acgctggccg agtggtggac ggcccggcgc ggcggtgcgg gcgtgaacgc ccgcgagctc
    13801 gccgtctacg tcccctccca gatcgtcggc gcgatcgcgg gcgcggtgct cgcggacgcg
    13861 atgttcggcg agccgctggt gaagtggtcc acgcacgacc gttcggccgg gaacctgctc
    13921 ctcggcgagg tcgtggcgac ggccggcctg atcctgctga tcttcggcct ggcccgtacc
    13981 gaccggctcc gcttcgcgcc cgtcgccgtg gcctcgtaca tcggcgccgc gtactggttc
    14041 acctcgtcga cctcgttcgc caacccggcc gtgacgatcg gccgcgcctt caccgacacc
    14101 ttcgcgggca tcgctcccgc ctcggtcccc gccttcgtcg gcatgcagct catcggcgcg
    14161 gccgtgggtc tcgccctggt cgcggtcatc ttcacgcgcg ggaagacgga cgccgagtga
    14221 cgcaggtcgt ggacgtggtg gtgatcggcg gcggccagtc cgggctcgcc gccggttacc
    14281 acctgcgccg cctcggcctc gacttcgtcg tcctcgacgc ccaggccacc cccggcgggg
    14341 cctggcagca cacctgggac tcgctccacc tcttctcccc ggccgcgtac tcctcgctgc
    14401 ccggccggcc gatgccgccg cagccgggcg agacgtaccc ggaggccgcc cacgtcgtca
    14461 cgtacctctc cgactacgag cagcggtacg agctccccgt cgtccggtcc gtccgcgtcg
    14521 aagccgtcca ccgcgacggc gagttcctgc gcgtcgaggc cgatgccggc acctggcggg
    14581 cccgtacggt gatcagcgcg accggcacgt ggcggcgccc cttcgtgccc gccgtccccg
    14641 ggcgtacgga cttcaggggc gcccagctcc acaccgtgga gtaccgcggc ccgcgcgact
    14701 tcgccggaca gcgggtgatc gtggtcgggg gcggcaactc cggcgcccag atcgccgccg
    14761 acctcgcgta cgacaccgac ctgacctggg tcaccctgcg cgaaccgcgc tacctcgccg
    14821 acgacatcga cggccgcgcc ctcttcgacc atgccaccgc ccgccgccgc gcactggacg
    14881 aggggcggac ggacacggga ggcgtggctt cactgggcga catcgtcgcc gtcccacccg
    14941 tacgcgaagc acgcgacgcc ggactcctca aggcccagcc gatgttcgcc cgcctcaccg
    15001 cgaccggagt cgagtgggcc gacggcatga ccgccgatgc ggacgccgtc atctggtgca
    15061 ccggcttccg ccccgccctc tcccacctcg ccccgctcgg cctgcgcggc ccccgcggcc
    15121 gcgtccccac gtccggcacc cgggccctgg gcgaaccccg cctccacctc ctcggatacg
    15181 gggactggac cggcgccgcc tccgcgaccc tcatcggcgt cggcaggccc gcccgggaag
    15241 cggcccgcga gatcgccgga ctcctcggcg gcgggtgagc ccgcggagcg cgtaccgccg
    15301 ccgaggagtc cgccctcggc cggcgcggct gacgcgggtc agtcgatgtg agggctacgg
    15361 cgttcgacga ggaccgtgtc acgccagcgg ccgtggtggc ggccgatccg ctcgcgggtg
    15421 ccgatgaccc ggaagccggc ccgctcgtgc acggcgagac tggcggcgtt ctccgggaag
    15481 atgccggact ggatcgtcca gattccggcc gcctcggtgg agtcgacgag tgccttgagg
    15541 agtgcggagg cgacgccccg gccgcgggcg tcggggtgga cgtacaccga gtgctcgacg
    15601 acccctgcgt acgcgcaccg gtcggagacc cggctggcgg cgacccagcc gaggacgcgg
    15661 ccggtctcgt cgacggcggc gaagcggtgc tcggagagcc tggccgcgtc gaactcggcc
    15721 caggtggggg cggtggtctc gaaggtggcg tcgccctcgt cgattccggc ccggtagatc
    15781 gcgacgacgg cgtcggcgtg ttccgcggtg agcgggacca cgacggtggg cgcggcggtc
    15841 acgcggcggc ggccttggtg agcagcgcgc ccatcgccgc gaggacggcc ggttcgatcc
    15901 ggtagtagac ccaggtgccg cgccgctcgg aggagagcag tcccgcctcc ttgagcttct
    15961 tcaggtggtg ggacacggtc ggctgggaga cgcccacgtc ggagatgtcg cagacgcacg
    16021 cctctccgcc ctcgtgcgac gcgaccgagg agaacagccg caaccggacc ggatcgccca
    16081 gcgccttgaa catgacggcg gtccgctcgg cctcctcggc cgtcagcgga cgctcggcca
    16141 gcggcgggca gcagggttcg acggcgggct ccaggagcgg caggaccttc gcattcgaca
    16201 tatgtctatg ttgacacacg tcgaaccagg cacccagggg tcgcgtgcgc gtcgccgccg
    16261 cgcaccccgc acgcactcga ccaattcgat gagtgtctat gttgacgctc gtcgatatgg
    16321 gtgccatgct gaggacggaa gagatcgaca aacgtcgaat cacaagggga atcgccatga
    16381 acgccacagc cgcagccacc gccaccgacc agctgcccgt cgtggtcatc ggggccggcc
    16441 ccgccggtct ggccgccgcc gcgcacctcg tcggccgggg cctggagccg ctggtcctgg
    16501 aggccggggc gcgggcgggc gcggcggtgc gcgagtgggc gcacgtacgg ctcttctcca
    16561 cctggggcga ggtcaccgac ccggccgccg agaagctcct cgcccccacc gggtgggtga
    16621 agcccgacgc gacggcctac ccgaccggcg gcgactgggc ggccgactac ctccagccgc
    16681 tcgccgacgt cctcggcgac agggtgcgcg tgggcgcccg ggtcaccgga gtctcccgcg
    16741 caggccgcga ccggatcgtc gacgccgacc gcgagaccca gcccttcacc gtccacgtcg
    16801 cccacgccga cgggcgcgag gagcggatcc tcgcccgcgc cgtcatcgac gcctccggca
    16861 cctggtcggt cccgagcccg gccggcggcg acggcctccc cgccctcggc gaacgcgcgg
    16921 ccgccgcccg gatctcctac cgcgtccccg acctcaagga ccccgccgta cgggcccgcc
    16981 acgcggggaa gcgcaccgcc gtcatcggct ccggcgcctc cgccttcacc gccctcgcgt
    17041 ccctcgccga cctggcgaag tccgaggacg gcacgggcac gcacaccacc tggatcctgc
    17101 gccggggcat ctccggctcc accttcggcg gcggcaccgc cgaccagctc cccgcccgcg
    17161 gcgccctcgg cctcgccgcc aaggccgccg tcgacgaggg ccacgccgac gccgtcaccg
    17221 gcttccgcac ggacgcgatc gagcgcgacg gcgagcggct cgtcctgatc gccgaggacg
    17281 gccgccgcct cgacccggtc gacgaggtca tcgtcctgac cggcttccgc cccgacctgt
    17341 ccttcctcga agagctccgt ctcggcctgg acgagcgcct ccaggccccg gtcgagctgg
    17401 cccccctcat cgaccccaac cagcactcct gcggcacggt ctacccgcac ggcgtgaagg
    17461 agctggcgca cccggaggag ggcgtctacc tggtcgggat gaagtcctac ggccgcgcgc
    17521 cgacgttcct cgccctgacc ggctacgagc aggtccgctc cgtcgtcgcc gcgatcgccg
    17581 gcgaccacga gtccgccgag cgcgtcgaac tcgtcctccc ggagaccggg gtctgcggcg
    17641 gcgccggcct cttcgaccag ccggccggcg acagccagtc cgacggcggc ggttgctgcg
    17701 cccccgcccc ggccctcatc cagc
//
