LOCUS       NZ_AKXV01000030        25735 bp    DNA     linear   CON 20-MAR-2024
DEFINITION  Streptomyces sp. SS scaffold16_1, whole genome shotgun sequence.
ACCESSION   NZ_AKXV01000030
VERSION     NZ_AKXV01000030.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. SS
  ORGANISM  Streptomyces sp. SS
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 147648)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Yu,Y., Chen,R. and
            Hong,B.
  TITLE     Draft genome sequence of Streptomyces sp. strain SS, which produces
            a series of uridyl peptide antibiotic sansanmycins
  JOURNAL   J Bacteriol 194 (24), 6988-6989 (2012)
   PUBMED   23209237
REFERENCE   2  (bases 1 to 147648)
  AUTHORS   Wang,L., Xie,Y., Li,Q., He,N., Yao,E., Xu,H., Chen,R. and Hong,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2012) Key Laboratory of Biotechnology of
            Antibiotics of Ministry of Health, Institute of Medicinal
            Biotechnology, Chinese Academy of Medical Sciences and Peking Union
            Medical College, No. 1 Tiantan Xili, Beijing 100050, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. Sep-6-2010
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000302615.1-RS_2024_03_20
            Annotation Date                   :: 03/20/2024 03:40:40
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,332
            CDSs (total)                      :: 7,257
            Genes (coding)                    :: 6,818
            CDSs (with protein)               :: 6,818
            Genes (RNA)                       :: 75
            rRNAs                             :: 2, 1 (16S, 23S)
            complete rRNAs                    :: 1 (23S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 440
            CDSs (without protein)            :: 439
            Pseudo Genes (ambiguous residues) :: 0 of 440
            Pseudo Genes (frameshifted)       :: 293 of 440
            Pseudo Genes (incomplete)         :: 173 of 440
            Pseudo Genes (internal stop)      :: 7 of 440
            Pseudo Genes (multiple problems)  :: 33 of 440
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:58:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 121913
            Orig. end                         :: 147648
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AKXV01000030.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25735
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="2"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..25735
                     /SMILES="NC(CCC(=O)N)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25735
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[20000:23816](-)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..23816)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     misc_feature    259..274
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.8"
                     /tool="antismash"
     gene            598..981
                     /locus_tag="Y19_RS0109365"
     CDS             598..981
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004921509.1"
                     /locus_tag="Y19_RS0109365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_026057906.1"
                     /transl_table=11
                     /translation="MAEKSKSSRPSRGEPSRDGMAGQHGWSPDVDETRQQENPSASRSF
                     HPEKHAPPPGKGRKVAKEEEQEVPGDTVHSDTTRGEKRGRSSEKGMRDTGRRGRTQRPS
                     GTKDDSAFTGVNPDDDSSGPRPG"
     gene            complement(1014..1757)
                     /locus_tag="Y19_RS38155"
     CDS             complement(1014..1757)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Y19_RS38155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_128643127.1"
                     /transl_table=11
                     /translation="MSWCGWASGWWWRSRRIAAFGCRAGYAGANVAALRAYGRLGRPLV
                     PGGRDAWDAALVALGGTGRSAHERTSALVIGAAGRCGAGACEALERAGIRATRWGHDET
                     RRLDRKALPAHDLLVNAIGTATPVAPFVTKADLDDPGRRLRLLCDVTCDVGSPCNAVPV
                     YDRPTTWAEPVVRVHEGDPPLDVIALDDLPSLLPTESSRAFSADLWPHLLTLRPDGPTG
                     PARVRGLDAFRRSLLRVLGSDSVGA"
     gene            complement(1856..2332)
                     /locus_tag="Y19_RS42515"
     CDS             complement(1856..2332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445261.1"
                     /locus_tag="Y19_RS42515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmpS family transport accessory protein"
                     /protein_id="WP_017237520.1"
                     /transl_table=11
                     /translation="MPTTEEPNRRIDRIDRRGVAVAAALLLVCGAFVTYGFIDTETDDE
                     AAGERAATPTAVATYDVTYEVLGEGAADVSYRGPGGDEAQVVTHVGLPWRKTVSVPLGA
                     SPIVNVTLGENGGTASCTLAVRGKHVQRATATGAFGRTTCGGEPPAPAAPAAPQ"
     misc_feature    complement(2288..2302)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    complement(2426..2435)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.08"
                     /tool="antismash"
     gene            2677..10581
                     /locus_tag="Y19_RS38165"
     CDS             2677..10581
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033679.1"
                     /locus_tag="Y19_RS38165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNRLRE domain-containing protein"
                     /protein_id="WP_337523457.1"
                     /transl_table=11
                     /translation="MIPQVAHAAPVSSDEGEGIADTFAGWFTDDEDEGGPELPSTGGSP
                     TLPSREKLPQGKAAGKPKRVAELTDRRTANARYWKLSDGRVQAEVSAEPTAYRSGKSWK
                     DIDPTVTAAGSGGFAFTNTTNVARTSFGADAARLLRFEAGNGHAVTLGLEGAGTLAPVA
                     KGDTVTYKDAVAGADLTYQVGPGRVKENIVLDSRPAGPVTFTFTLDAGGLTPKAGEDGS
                     IRFYGEGADPVLVVPAAFMTDARKDASSPYGTGHSSAVEQKLVRAGKSWKLTVTPDAKW
                     LAAPERQYPVTIDPTISIAPTPSTAQDVMISSDGPGENYDENWRLSVGNTSTGTSRALL
                     RFPLTGVPAGTKLDSADLKLYYDQTHTTGDTEVQLEAHRATQAWTEDKATWNSANALTG
                     ELSGTSVVVDDGDAGRTAAVGAWPASANTAYTQYAVNQDYLYNKDSVAGDTYTWQPNLP
                     EDGTYQVEAHYVPASDRATSAPYTVTYDGGSKAYTVNQQAGTAGVWKTLGSHPFKAGTL
                     GKIALGDAGASTTTSVIADAVRFTKGGVVTKKPGELNTWHSFAVTKTVQQWIDGAYANN
                     GFVIKAGDESANGPKGGPRYEGSEYGYGGETAHYPRLVLTFGRQGVDLATPTVIHDTGA
                     ELAWSAYQDPDPIGTGDDIAEYQVHRSVSQAFTPSAATLVAPVASSTTSFTDTSAVPTR
                     ADDPDPLGRAYYYMVAVKTRDGQVLAAPSKLVRLPKAGRTTKVLDATQDTTLSSARPTS
                     PLDTIDEGGPKNWLSVGNNSVTLGDTRAVLKFPALGIPTTARVVEANVRLWSTQTTTDA
                     AGAVYELRPLTRDFDESAATWVKADAAANWAAAGGDFGAVASDTGAKTNDPSRHDWNVT
                     SLAQSWVTTPSSQRGVVLKMADEAAQQERTLFLSSEGTEQRLRPRIAVTYIDSTTESTY
                     YAPQTPARITPNSDHTVEFTLTNTTTSVWKAGTHVLSYRWALPDGTDATNGGNQLQTAL
                     PADLLPGDSVTLQARLRAPINSGSGSKRTEYVLTWDVRDTVAGTWLSATGGPAGLRQNV
                     TVEDPTSDQLGLEKFYSYNGKNTGAGSSLMNNTAVGNSVWQYNALSNPGRGLNTFVRFA
                     YNTQDTSDTVAGHGWSVQAAGPIRLGAPLDFHPNPNPREVRLPDGDGTTHVFRVQPDGT
                     WKAPAGVHFRLSAKPGLDCTPAKDPIPDAWTLTRPDGTRFLFGCDGYQTSVVDKNGNTQ
                     TFTYEERKSNNKPTKFLSYITDPAGRQTLTATYFTKAEASSPKIVDHLKTITDVSGRKL
                     AFEYSDKGLLTKLTDGAGSSQPKVFGFTYDAEQGNKNVKLVRVTDPRGNATALDYYYPS
                     EGDDPKYHWWTQSITDRISGVTGFAYAADTADTRFTSTVVTDAEGHDATYVTDDFGRPV
                     RSVNAKSQQTKLAWDADNNVTYMEENNGAVTAYCYDPLTGYPLWKRTAEHNKGGVPPQS
                     DCAPGKYPADSQKFEYVKRLDGYSSDLSRKTSPEGRAWQFGYDSFGNLKTVTDPKGVAT
                     PTAGDYTTAYEYDTYGQLTKATDANGHATVNSAFTPTGYPAKITDALGNSIGYEYDVRG
                     KVTKTTDPLGSRTTQTYDTYGRPLVRTAPRDQAAGDLITVPAPDYDANDNVTKAIAPTG
                     AVSTAVYDAADQLTEATSPQDTPTAPLRRTVYTYDKTGHLKTTTEPKGVATSGIPDDYT
                     TTQNYDEIYQLASVVNALGEKITYTYDEVGNNVKVVDPKKNRTADPDDFSSKMTYDLEH
                     RVTSVTDPLGNVTRRAYDKDALVVADTDPDGNTTYSGYDERGRKTEQRVPHSGSGTGIT
                     YRTTRYEYDQVGNATRVVTPRGTETANADDFTSRTEYDELNRPVKQYLPYDPADARYNK
                     PNVYTQTFYDAAGRVTRTSQPPSEGQTVRNDTEYTYYDNGWTKSSTDPWDIKTSYEYND
                     LGLQTSRTLSSAGGSVSRTMGWSYYPNGKLKEKTDDGVPVGTAVPLVDNSDAQNTGSTG
                     TWTTASLTGQQGFDHRVHAAGAGTDAYSWTLNIPKNGKYTAYVKFPQVAGASKTAKYKV
                     THGAGSTDRTVDQSTAAGTWVSLGTYDFTQGNAAKLELFQATDGKVVADGVKLVRDLTG
                     DIDAEKHHFRYAYDLNDNLSLIDDLSSGAEVDAYTISYTGLNRVSGITETLAGQQKTST
                     SYTYDANDQPESITHPDQYSKYTYDLREKVKAVSVGTSPTDTDPKVTSYTYTDRGESLR
                     ETKDNGNTVDFEYFLDGAVRTSAEKKADGTLVASHTYAYDANGNKAQDAAKKMNADNHA
                     AYLESTTAYTYDPVDRIAKSVKTGNGAATETYVHDDNANVVQQNVGGTATDFRYDRNRL
                     QTSTSAGSVTSFNYDPLGRQESTSQGGQIVSRSIYDGFDHVVESQQRDGTGAMKSTKYT
                     FDPLDRTSSKTADGKTTDYRYLGLSQEVLTEEVAGKLTKSYQYSPWGQRLSQVKHNENG
                     TTEDAYYGYNSHTDVETLTDATGNTKATYGYTAYGNDDSSEFTGIDKPDASDPTKEEYN
                     SYRYSAKRWDAGSGTYDMGFRDYDPGLNQRGPGRHGPGQRPLHRQPLRLHRRQPDQQRR
                     DRRPLVRPRDPGGRRGLRRGGRGGRRRHRRRRGRRVRRQRGPGPDRRGQPVA"
     gene            10490..11230
                     /locus_tag="Y19_RS45085"
     CDS             10490..11230
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025298.4"
                     /locus_tag="Y19_RS45085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA/RNA non-specific endonuclease"
                     /protein_id="WP_237749484.1"
                     /transl_table=11
                     /translation="MVVAVIAVAAAVEYVVNEVRDRIDEANRSRDDTADEPAPDPRRVP
                     RPQPEPDNDDDDKSGCGDGWIKYGDRDAANGNRATAAEACLTKEYLKNNKGTGVGSNPP
                     GYEWAQDYAKGKGLDAQKNVNACHLIGNKLAGKGVLANLSPCARGANAKQIGSTQGDDH
                     MRTYELQVYNAVMAGQDVMYSVSPRYDGNRTVPTGYDISAYGVNPDGSVGIDFQVFIPN
                     TLSTGDNLGTQSDNGSPVPTGSTP"
     gene            11282..11824
                     /locus_tag="Y19_RS41535"
     CDS             11282..11824
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Y19_RS41535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_017237522.1"
                     /transl_table=11
                     /translation="MSEPTDLDALRRLMPPPQDGDTTVDWTALATSWGKPFPDDFRRFM
                     EVYGAGAVQNYLSIGRPEAKVPLEQAERDGMVIETANAEADWETEEKTPELEGTSPELI
                     TWGVSATADMLCWDASNDDPAKWPVVVYHRNDMLWSRYDCGMVEFLVRNFRAEWPENPL
                     GGEFLWDVSEVTFQAQG"
     gene            complement(11928..12128)
                     /locus_tag="Y19_RS42520"
     CDS             complement(11928..12128)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017950123.1"
                     /locus_tag="Y19_RS42520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5988 family protein"
                     /protein_id="WP_128643139.1"
                     /transl_table=11
                     /translation="MAHKVSLEGGPEDLPERIVTVEIPGEDVKIPHRGGYEHFRETPHR
                     HDTKEGTLRVYEWWERTEIAE"
     misc_feature    12123..12133
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(<12429..13685)
                     /locus_tag="Y19_RS0109390"
                     /pseudo=""
     CDS             complement(<12429..13685)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021134.4"
                     /locus_tag="Y19_RS0109390"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="glycosyltransferase 87 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRPCNRLDGSRGRSDTLRNADALPRHRPRRPVSCQGDGVTQPPTT
                     GTRSTAVTAVLLAALASALVLTVRKDGYFADPAGLSWWYAICWVLFSAAVWNLRRTPAR
                     HVAALVLAGGVAVAVTGLVAPPRTSTDSFRYAWDGRVQAAGGSPYDHAPADPALAHLRD
                     TWLFPTGAACGKPDLAPVADGVCTRVNRPRVHTVYPPAGELYFLLAHTVSPDGVRHKAL
                     QTGGAALAVATTVVLLRILRRRGDPRTAAYWAWCPAVPVEAVNNAHADVLAVLLSVAAL
                     GLTVRHRALGGALLGLATAVKLLPAVLIPGALSGVHRPRPAAATLVPAAAVLAALYLPY
                     VWASRHSVMGYLGGYAEEEGYQDASSGGRYALLRWVLPDAWALPAVLAGMLAVSLYVIR
                     RGDAGRPWSGALLVTGTAFL"
     misc_feature    complement(13635..13637)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13684..14886
                     /locus_tag="Y19_RS0109395"
     CDS             13684..14886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016573594.1"
                     /locus_tag="Y19_RS0109395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_017237524.1"
                     /transl_table=11
                     /translation="MGSRIGRRLRVPAFRLPAPPPRLTALRPPAFSGRLHDPRTATAIG
                     RWLGVALAVCFLTGLISHFLQNPPGWLAGYLPSRPVWGYRLTQGLHVGVGLAAIVLLPA
                     KLWAVYPRLFVWPPVRSVTHGLERLSVAVLVASGVFQVLTGLLNIAEWYPWPFSFVPVH
                     YAVAWIVAGSVLLHLAVKAPEIRAHWGRRSAGTLALPDAERDGPDRRALLIGVGSAVGA
                     VTVTTVGQSFTPLASLDLLAPRHPGYGPQGLPVNRTAAAAGVTEDGLRGWYLEVLGPAP
                     FRLTLDELRALPQAGARLPIACVEGWSVDARWSGVRIRDLMARAGALPGSGLRVVSLEV
                     RGAYRVMEMGREYAQDPLTLLALRLNGEVLSADHGHPARIIAPNRPGVLQTKWVTRLEV
                     L"
     gene            14883..15485
                     /locus_tag="Y19_RS45090"
     CDS             14883..15485
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037690.1"
                     /locus_tag="Y19_RS45090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_017237525.1"
                     /transl_table=11
                     /translation="MKSEPGAESEPEPGAESVPEPGAESEPEPDSEPEPVSGPVSAVRY
                     ALGVLGLLLIGIGGWHLSSQPDPYDVLVWLGGALVLHDGVIAPLVLAVGLLVAAVPARR
                     VVRGALVTGGALVLVTLPLLLRPGVPPNPSALPLPYARNLLLVLAVVTGVTVVWVGLTR
                     LRWRGTPGVRDKRAVSSEVGSGAPEGRGPGAQAPPED"
     gene            complement(15690..16325)
                     /locus_tag="Y19_RS0109405"
     CDS             complement(15690..16325)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657081.1"
                     /locus_tag="Y19_RS0109405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2064 domain-containing protein"
                     /protein_id="WP_017237526.1"
                     /transl_table=11
                     /translation="MTSLLVIAKQPSPGRVKTRLTPPFTPEEAAALAEAALADTLTAVA
                     ATPADRHVLVLDGAPGPWLPPGFEVVPQGVGGLDERLAAAFAGCTGPALLIGMDTPQVT
                     PGLLTPALEFGRYDAWFGRAADGGFWALGLAVPDPALLLGVPMSAPETGAVQYGRLRAA
                     GLRAGLLPVLRDVDTADDAHEVAAQAPAGRFGVLHQRLTAGLLPSAGG"
     gene            complement(16322..17023)
                     /locus_tag="Y19_RS0109410"
     CDS             complement(16322..17023)
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007451594.1"
                     /locus_tag="Y19_RS0109410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_017237527.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.6e-23,
                     bitscore: 75.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQDTVDVVLPCLNEAEALPWVLARIPAGWRALVVDNGSTDGSAE
                     LARSLGATVVAESRRGFGAACHAGLLAAEAEYVCFCDCDASLDPGLLTGFVRTVAADRA
                     DLVLGRRRTQGRGAWPLHARAGNHALSRMLRRRTGLRLRDLGPLRAARREALLGLDLTD
                     RRSGYPLQMVVRAADAGWRVREEDVPYLPRAGKSKVTGTWRGTWHAVRDMRAVLAEPPY
                     ATAAGRSGGAR"
     gene            complement(17225..18261)
                     /locus_tag="Y19_RS38175"
                     /pseudo=""
     CDS             complement(17225..18261)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358822.1"
                     /locus_tag="Y19_RS38175"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /pseudo=""
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.6e-06, bitscore:
                     20.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.6e-06,
                     bitscore: 20.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLVTGGAGFIGSHVVAALAAEGHEPVVLDALLPAAHAVEPELP
                     DAEFVRGDVRDPGTVRAALRDVDAVCHQAAMVGLGKDFADAPAYVSCNDLGTAVLLAGM
                     AETGVRALVQAGSMVAESTVWCGPGPGRSRTCGRAGSNRAARCAGRSSRPGWWTRTPPL
                     IPGTPTRRRNWPRRTWPRPGPGPSGGPRCRCATTTCTGPGCPGTPPTRAWRRSSGRRWP
                     GERRPGCSRTARSAGTSSTSGTWPGRTRPRWQASQASRPGATPSTTSGAETRTPSARWR
                     RSWRRRTAGPRRW"
     gene            18462..19844
                     /locus_tag="Y19_RS38180"
     CDS             18462..19844
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="Y19_RS38180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_017237529.1"
                     /transl_table=11
                     /translation="MNATQARPVAGTAVVVGASMAGLCAARVLSERFRNVVVIDRDTLP
                     RSPQWRSHVPQGRQPHLLLYSGAQLLERWFPGIDEELCKGGATEFDICRDFYWHQGGGP
                     LARPPSTMHGPVMSRPFLEETVRRRVTELPEVIVRDGTAVVGVVADDAGRRVIGVRLSD
                     GSALVCDLLVDATGRQARSLGWLKELGYAGPPVSHVAVDTHYASRTYRREALPPRDWKA
                     AAVIGAPETRRLAVALPWEGGRWIVGLVGVNGELPPTDEAGRIAFARSLGSPVIAELME
                     ASEPLGEPVAYRFAANQRRHVEKMRHYPLGWVLIGDAVCSLDPIYGQGMSTAAQQAAAL
                     ADCLDRSSGIDRTFTRSYFHAATRPVARAWSITVGGDFAYAGTTGSKPPGTDLLNRYMA
                     RVNIAAQHDATVCIRFSEVAGLIRRPEWLLTPAFVLRVLRFARRGPAGEHPAPASAGTQ
                     AA"
     gene            complement(20001..23816)
                     /locus_tag="Y19_RS0109430"
     CDS             complement(20001..23816)
                     /NRPS_PKS="Domain: AMP-binding (23-418). E-value: 3e-111.
                     Score: 363.9. Matches aSDomain:
                     nrpspksdomains_Y19_RS0109430_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (930-998). E-value: 9e-20. Score:
                     62.7. Matches aSDomain: nrpspksdomains_Y19_RS0109430_PCP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543279.1"
                     /locus_tag="Y19_RS0109430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_017237530.1"
                     /sec_met_domain="AMP-binding (E-value: 5e-117, bitscore:
                     383.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.5e-15, bitscore:
                     50.4, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 8.8e-22, bitscore:
                     71.3, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTAPLNARIHTAHLGSCLTDLLREQAEAQPEAVAVACDDQSLTY
                     RELVQAASGLAASLRRLGVGADDCVGLYVEPSLDLMAGAWGILFAGAAYLPLSPEYPED
                     RLRYMIEDSRTRVVVTQDHLADRLAELAPSGTRVVTQERNTGAGAPPPRPDALAYVIYT
                     SGSTGRPKGVMIEHRGIASQMRWMHSCGHVGKGTTVLQKTPMSFDAAQWEILAPAMGGR
                     VVMGAPGVYRDPQALAETIVKHEVTTLQCVPTLLQALLDTDDFTLCTTLRRVFSGGEAL
                     SRQLARTFADEVPWASLVNLYGPTECTINATAHLVDPDEIGEGPGTIPIGVPVDNTQCF
                     ILDEDLAPVDIGETGELYIGGVQLARGYLHRPDQSRERFVPSPFVPTERLYRTGDLAYW
                     NPDGTIQFSGRADNQIKLRGYRVELDEIALAIEEHTWVRRAAAVVTDDTRTGFQNLVAC
                     IELNPKEAALMDQGNHGGHHRSKASKLQVKAQLSNPGLRDPEELHDRPVTELPGKQESP
                     GQRRETFARKTYRFYEGGNVTRSDVLELLAPRRVGDFSRGLDEVTFAELGEMLRWFGRF
                     RSDERLLPKYAYASPGALYATQLYLETGGIHGLDSGVYYYHPVDHTLVRIGPAATGSGA
                     WLSAHFVGKKRAIQPVYKNNIQEVLEFEAGHMVGLFEEVLPEYGLDISPLAFRPSVKSR
                     LDVADEDHYLGTFAIHPCDGAPRQDPTEIYVQAHPGRVEGLPTGQYRYADGELERLSDD
                     LVLRKHVIAINQKVYERASLGVTAVSRADQPWLEYISLGTKLHHLQRNGLGLGFMSSGY
                     SSKSGHPLPAARRVDDILASCGIGPGASYFFLGGRVSEEQIRSEGMYEDTVHMKGPAEI
                     IKDELAGLLPDYMIPSRVLVVDELPLTANGKVDAKALAASEEVTSADTGSPYVAPSTRA
                     ERWLAEAWGKALKYENVSVEDEFFASGGNSLSAVALINRINKEFGTRLPLQVVFEHPKL
                     AELAHRIDSGDSAPSSRLVPLHDEGAGSPVFCWPGLGGYPMNLRLLGREAGAGRPFYGV
                     QAHGINAGETPYPTIREMAAADVTEIRRLRPEGPYTLWGYSFGARVAFEAAWQLEQAGE
                     QVDDLLLICPGNPKVREADGDRHGREASYRNPAYLTILFSVFAGSVSGPELARCLTAAQ
                     DEDGFVSFVHDLLPVLDKRLIRRITRIVGETYEFEYSFRELAERRLDAPVTILKASGDD
                     YSFIEGRTGYSAAPPTIVDLDGDHYSVLKEHGVAELASAIRAHLGT"
     CDS_motif       complement(20511..20582)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0109430_0005"
                     /evalue="1.10E-10"
                     /label="NRPS-te1"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="1102"
                     /protein_start="1078"
                     /score="33.9"
                     /tool="antismash"
                     /translation="PEGPYTLWGYSFGARVAFEAAWQL"
     aSDomain        complement(20823..21026)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Y19_RS0109430_PCP.1"
                     /evalue="9.00E-20"
                     /label="Y19_RS0109430_PCP.1"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="998"
                     /protein_start="930"
                     /score="62.7"
                     /tool="antismash"
                     /translation="ERWLAEAWGKALKYENVSVEDEFFASGGNSLSAVALINRINKEFG
                     TRLPLQVVFEHPKLAELAHRIDS"
     aSModule        complement(20823..23747)
                     /complete
                     /domains="nrpspksdomains_Y19_RS0109430_AMP-binding.1"
                     /domains="nrpspksdomains_Y19_RS0109430_PCP.1"
                     /locus_tags="Y19_RS0109430"
                     /monomer_pairings="Gln -> Gln"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(22536..22598)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0109430_0004"
                     /evalue="3.60E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="427"
                     /protein_start="406"
                     /score="28.8"
                     /tool="antismash"
                     /translation="FSGRADNQIKLRGYRVELDEI"
     aSDomain        complement(22563..23747)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Y19_RS0109430_AMP-binding.1"
                     /evalue="3.00E-111"
                     /label="Y19_RS0109430_AMP-binding.1"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="418"
                     /protein_start="23"
                     /score="363.9"
                     /specificity="substrate consensus: Gln"
                     /tool="antismash"
                     /translation="REQAEAQPEAVAVACDDQSLTYRELVQAASGLAASLRRLGVGADD
                     CVGLYVEPSLDLMAGAWGILFAGAAYLPLSPEYPEDRLRYMIEDSRTRVVVTQDHLADR
                     LAELAPSGTRVVTQERNTGAGAPPPRPDALAYVIYTSGSTGRPKGVMIEHRGIASQMRW
                     MHSCGHVGKGTTVLQKTPMSFDAAQWEILAPAMGGRVVMGAPGVYRDPQALAETIVKHE
                     VTTLQCVPTLLQALLDTDDFTLCTTLRRVFSGGEALSRQLARTFADEVPWASLVNLYGP
                     TECTINATAHLVDPDEIGEGPGTIPIGVPVDNTQCFILDEDLAPVDIGETGELYIGGVQ
                     LARGYLHRPDQSRERFVPSPFVPTERLYRTGDLAYWNPDGTIQFSGRADNQIKLR"
     CDS_motif       complement(22680..22766)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0109430_0003"
                     /evalue="1.50E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="379"
                     /protein_start="350"
                     /score="46.0"
                     /tool="antismash"
                     /translation="IGETGELYIGGVQLARGYLHRPDQSRERF"
     CDS_motif       complement(23286..23345)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0109430_0002"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="177"
                     /protein_start="157"
                     /score="36.3"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGRPKGVMIEH"
     CDS_motif       complement(23526..23564)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_Y19_RS0109430_0001"
                     /evalue="1.90E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="Y19_RS0109430"
                     /protein_end="97"
                     /protein_start="84"
                     /score="11.8"
                     /tool="antismash"
                     /translation="WGILFAGAAYLPL"
     gene            complement(23813..24724)
                     /locus_tag="Y19_RS0109435"
     CDS             complement(23813..24724)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018543280.1"
                     /locus_tag="Y19_RS0109435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="EamA family transporter"
                     /protein_id="WP_017237531.1"
                     /transl_table=11
                     /translation="MKGGRPAFDSALTALAPAVWGSTYLVTTELLPADRPLLASTVRAL
                     PAGLVLLAIGRVLPRGVWWWRASALGVLNIGAFFYLLFVAAYHLPGVQPMLVLLLGALL
                     LKERIQRVQLAACVLGVLGVALLVLQPRAGLDSVGVLAGLAGAVSMASGIVLTKRWGRP
                     EGVGVLTFTGWQLTVGGLVLAPVMLVAEGLPGEITGTNITGFAYLSVIGALFAYAIWFR
                     GIGRLPALAVSVLGFASPLAATLLGYAFLDQKLSVLQAAGAMAVVVAVVLAQPRPERNA
                     RAGTGGPSLMSRQHAPAGRGKP"
     regulatory      complement(25360..25446)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
ORIGIN
        1 cgtcgcccgc gtccatctcc tcgtcggcct ggaggacggt gacgccccac tcctcgaccc
       61 cgtcgaggat cgcgtggtcc agcgaggacg ggccccggtc gcccaccggc cccgggtgca
      121 cgatcaggca gcggtgcgcc gtccacacgt cgcggggcac gacggccttc agtagggggg
      181 ccacgaccag atcgggcgcg tggcgcgcca cggcctcgcg cacggcagcg ccgtcgggcg
      241 tgacctccac gggaacggtg tgcccgcggt cacgcagctc gaccaggaca cgctgggtga
      301 gactgttgaa gctgctggcg acgagcagga tgcgcatggg cggcctttcc gggtcgcggt
      361 ggacggtacg gccctgggaa ccgcagtcca ccgaccgcct gcgatcatcg ggcagcgcga
      421 gccgggcagc ggggtgacgg agcccgcacc tcacccgttc gaggtgtgcg tccgaccgat
      481 tggcgggctg atcgccacgg tgcgcggtcc aggagacgcg ccatgtgtcc cgtgggaaaa
      541 tcgaagtcct acaggtgtgc ggacgcatac ctcccgtacg gacgggcagg tcggctcatg
      601 gccgagaaat cgaagtcctc caggccctcg cgcggcgagc ccagccgcga cggtatggcc
      661 gggcagcacg gatggtcccc cgatgtggac gagacgcggc agcaggagaa tccgagcgct
      721 tcgcgttcct tccaccccga gaagcacgcg cccccgcccg gcaagggccg gaaggtcgcc
      781 aaggaggaag aacaggaagt ccccggcgac accgttcaca gcgacacgac cagaggtgag
      841 aagcgaggcc gctcgtcgga gaagggcatg cgcgacaccg gccgaagggg ccggacacag
      901 cgccccagcg gcacgaagga cgactcggcg ttcaccggcg tgaacccgga cgacgactcc
      961 tccggccccc gcccgggctg acgcgcagtc tcgcggttcc cgtgaccgcg ccctcaagcg
     1021 ccgacggaat cgctccccaa aacgcggagg agtgaccgcc ggaacgcgtc caggccgcgc
     1081 acccgggccg gccccgtcgg gccgtcgggc cggagcgtga gcagatgggg ccacagatcg
     1141 gcggagaagg cgcggctcga ctccgtgggc agcagcgacg ggaggtcgtc gagggcgatc
     1201 acgtcgagcg gcggatcgcc ctcatggacc cggaccacgg gttccgccca ggtcgtgggc
     1261 cggtcgtaga cgggtaccgc gttgcagggt gatcccacat cgcacgtgac atcgcacagg
     1321 aggcggagtc ggcggcccgg atcgtcgagg tcggccttgg tcacgaaggg cgccaccggc
     1381 gtcgccgtgc cgatggcgtt gaccagcaga tcatgggccg gcagcgcctt gcggtccagg
     1441 cgccgcgtct cgtcgtgccc ccaccgggtg gcgcggatcc cggcccgctc cagcgcttcg
     1501 caggctcccg caccgcaacg cccggccgcg ccgatcacca gggccgacgt cctttcgtgc
     1561 gcggatcggc ccgtgccgcc gagcgcgacg agcgcggcgt cccacgcgtc cctgccccca
     1621 gggaccagcg gacggccgag tctcccgtac gcgcgcaggg cggcgacgtt tgcacccgcg
     1681 tagccggccc ggcatccgaa agcggcgatc cgccgactcc tccaccacca gccggacgcc
     1741 cagccgcacc agctcacccg cgtgctccgg cggcagaggt ccgggtggtg ggtgacgacg
     1801 cgcccgtccg gctgtccgga tcgccgcgcc gctgacgtcg gcgggttcgg cggattcact
     1861 gaggggcggc gggcgctgcg ggggcggggg gttcgccgcc gcaggtggtc cggccgaagg
     1921 cgccggtggc ggtggcgcgt tggacgtgct tgccgcggac ggccagggtg cagctggccg
     1981 taccgccgtt ctcgccgagg gtgacgttga cgatcggcga ggcgccgagc ggaacgctca
     2041 cggtcttccg ccagggcagg ccgacatgcg tgacgacctg tgcctcgtcg ccgcccggcc
     2101 cccggtagga gacgtcggcc gcgccttcgc cgagcacttc gtaggtcacg tcgtaggtcg
     2161 ccacggcggt gggcgtcgcg gcccgctcgc ccgcggcctc gtcatcggtt tcggtgtcga
     2221 tgaatccgta cgtgacgaac gcgccgcata cgagcagcag agccgccgcg acggctacgc
     2281 cgcggcgatc gatgcggtcg atgcggcgat tcggttcttc ggtcgtcggc atggcaggac
     2341 cttctgtcga ggaatcggat tgggttatac accaccggat tcgatggacg ccaggcaacg
     2401 gaaatgtcgg gcaaggcggc ttcaatcaca aatcgccggt cagcgaaatg ccccgtatgg
     2461 gcaatcggtt gacggcacat cagttccgtg gtgaagaatc ccaccgcccg cgatcgaagc
     2521 ttcggcgagg ccacttcccg caaggggaac gtggcctggt ttgccatgcg ttgaggcgct
     2581 tcggtcgatg ccggattcac cgaagagggg aatgacgtga aagtgagata cgggccggcg
     2641 atagcctgcc tcgtggtttc ggcggtcgtc ggaaccatga ttccacaagt cgcccatgca
     2701 gcaccggttt catccgatga aggcgagggt attgccgata ctttcgccgg ctggttcaca
     2761 gacgacgagg acgagggcgg gccggaactg ccgtcgaccg gcgggtcccc gacgctgccg
     2821 agccgggaga agctgccgca gggcaaggcg gccggaaagc cgaagcgcgt cgcggaactg
     2881 acggaccgtc gtacggcgaa cgcccggtac tggaagttgt ccgacgggcg cgtgcaggcc
     2941 gaggtgtcgg cggaaccgac ggcgtaccgg tcggggaagt cgtggaagga catcgacccg
     3001 acggtcacgg cggccgggtc cgggggcttc gccttcacca acacgacgaa cgtcgcgcgt
     3061 acgtccttcg gcgccgacgc ggcgaggctg ctgcgcttcg aggccggcaa cggtcacgcg
     3121 gtgaccctgg gcctggaggg cgcgggcacg ctcgcccccg tcgccaaggg cgacaccgtc
     3181 acgtacaagg acgccgtggc cggcgcggac ctgacgtacc aggtgggtcc ggggcgggtg
     3241 aaggagaaca tcgtcctgga ctcccggccg gccggcccgg tgacgttcac gttcacgctg
     3301 gacgcgggcg ggctgacgcc gaaggccggc gaggacggct cgatccggtt ctacggcgag
     3361 ggcgcggatc cggtcctcgt cgttccggcc gcgttcatga cggacgcgcg gaaggacgcc
     3421 tcctcgccgt acggcaccgg gcacagctcc gctgtcgagc agaagctcgt ccgggcgggc
     3481 aagagctgga agctgacggt cacgccggac gcgaagtggc tcgccgcgcc ggagcggcag
     3541 tacccggtca cgatcgaccc gacgatctcg atcgcgccga cgccgagcac ggcgcaggac
     3601 gtgatgatct cctcggacgg tccgggcgag aactacgacg agaactggcg gctttcggtc
     3661 ggcaacacca gcaccggcac gtcgcgtgcg ctgctgcggt tcccgctgac cggcgtcccg
     3721 gccggcacga agctcgactc ggccgatctg aagctgtact acgaccagac gcacaccacc
     3781 ggtgacaccg aggtccagct ggaggcgcac cgcgccaccc aggcgtggac cgaggacaag
     3841 gcgacctgga acagcgcgaa cgcgctcacg ggcgagctgt cgggcacgtc ggtcgtggtg
     3901 gacgacggcg acgccggacg gacggccgcc gtcggcgcct ggccggcttc ggcgaacacc
     3961 gcgtacacgc agtacgcggt gaaccaggac tacctgtaca acaaggactc ggtcgccggt
     4021 gacacgtaca cctggcagcc gaaccttccc gaggacggca cctaccaggt cgaggcgcac
     4081 tacgttcccg cctcggaccg cgccaccagc gccccgtaca ccgtcacgta cgacggcggg
     4141 tcgaaggcgt acacggtcaa ccagcaggcg ggcacggccg gggtctggaa gacgctgggc
     4201 tcccacccgt tcaaggcggg cacgctcggc aagatcgccc tgggggacgc cggggcctcg
     4261 acgaccacct cggtgatcgc ggacgccgtc cgcttcacca agggcggcgt cgtcaccaag
     4321 aagccgggcg agctcaacac ctggcactcc ttcgcggtga cgaagacggt ccagcagtgg
     4381 atcgacggcg cctacgcgaa caacggcttc gtgatcaagg ccggtgacga gtccgcgaac
     4441 ggcccgaagg gcggaccgcg gtacgagggc agcgagtacg ggtacggcgg cgagaccgcc
     4501 cactacccgc gtctcgtcct gaccttcggg cgtcagggcg tcgacctcgc gaccccgacc
     4561 gtcatccacg acacgggtgc ggagctggcc tggtcggcgt accaggaccc ggaccccatc
     4621 gggaccggcg acgacatcgc cgagtaccag gtccaccgct ccgtcagcca ggccttcacc
     4681 ccgtcggccg ccaccctcgt cgcacccgtc gcgtcctcga cgacctcgtt cacggacacg
     4741 agcgccgtgc cgacgagggc cgacgacccc gacccgctcg gccgcgccta ctactacatg
     4801 gtcgcggtca agacgaggga cggtcaggtc ctcgccgcgc ccagcaagct cgtacggctg
     4861 ccgaaggcgg gccggacgac gaaggtgctc gacgcgacgc aggacaccac cctgtcctcc
     4921 gcccggccca cgtcgcccct cgacacgatc gacgagggcg gcccgaagaa ctggctcagc
     4981 gtcggcaaca actccgtcac cctcggcgac acccgcgccg tgctgaagtt cccggccctg
     5041 ggcatcccca ccaccgcgcg cgtcgtcgag gcgaacgtcc gcctgtggag cacccagacc
     5101 accacggacg ccgccggcgc ggtctacgag ctccggccgc tgacgcgcga cttcgacgag
     5161 tccgcggcga cctgggtcaa ggccgacgcg gccgccaact gggcggccgc gggcggtgac
     5221 ttcggcgcgg tcgcgagtga caccggggcc aagacgaacg acccgtcgcg gcacgactgg
     5281 aacgtgacct cgctcgcgca gtcgtgggtg acgaccccgt cgtcccagcg cggcgtggtc
     5341 ctcaagatgg ccgacgaggc cgcgcagcag gagcggaccc tgttcctgtc ctccgagggc
     5401 accgagcagc ggctgcggcc caggatcgcg gtcacgtaca tcgactcgac gaccgagtcg
     5461 acgtactacg cgccgcagac cccggcccgg atcaccccga acagcgacca cacggtcgag
     5521 ttcaccctca ccaacaccac cacgtccgtg tggaaggccg gcacccacgt cctgagctac
     5581 cggtgggcgc tcccggacgg cacggacgcc acgaacggcg gcaaccagct ccagacggcc
     5641 ctgcccgccg atctgctgcc cggtgactcg gtcaccctgc aggcccggct ccgcgcgccg
     5701 atcaactcgg gctccggcag caagcgcacc gagtacgtcc tcacctggga cgtacgggac
     5761 acggtggcgg gcacctggct gtccgcgacg ggcggtccgg ccggcctccg gcagaacgtc
     5821 accgtcgagg acccgacctc ggaccagctg ggcctggaga agttctactc gtacaacggc
     5881 aagaacaccg gcgcgggttc atcgctgatg aacaacaccg ccgtcgggaa cagcgtctgg
     5941 cagtacaacg cgctgagcaa cccgggccgc ggtctcaaca ccttcgtccg cttcgcctac
     6001 aacacccagg acacctcgga caccgtcgcc ggtcacggct ggtccgtgca ggccgcgggg
     6061 ccgatccggc tcggcgcccc gctggacttc cacccgaacc cgaacccgcg ggaggtgcgg
     6121 ctccccgacg gggacggcac cacccacgtc ttccgggtcc agccggacgg cacgtggaag
     6181 gcgccggccg gcgtccactt ccggctctcg gccaagcccg gtctcgactg caccccggcg
     6241 aaggacccga tcccggacgc ctggacgctg acgcgcccgg acggcacccg cttcctgttc
     6301 ggctgtgacg gctaccagac gtccgtcgtc gacaagaacg gcaacacgca gacgttcacg
     6361 tacgaggaac gcaagtcgaa caacaagccg accaagttcc tctcgtacat caccgacccc
     6421 gccgggcggc agacgctcac cgccacctac ttcaccaagg cggaggcgag cagcccgaag
     6481 atcgtcgacc acctgaagac gatcaccgac gtctcgggcc gcaagctggc cttcgagtac
     6541 tcggacaagg ggctgctcac caagctgacc gacggcgcgg gctcgtccca gccgaaggtc
     6601 ttcggcttca cgtacgacgc cgagcagggc aacaagaacg tcaagctggt ccgcgtcacc
     6661 gacccgcgcg gcaacgccac cgctctcgac tactactacc cgagcgaggg cgacgacccg
     6721 aagtaccact ggtggaccca gtccatcacc gaccgcatca gcggcgtcac cgggttcgcg
     6781 tacgccgccg acacggccga cacccgcttc acctccaccg tggtcaccga cgccgagggc
     6841 cacgacgcca cgtacgtcac cgacgacttc ggccgtccgg tgcgctccgt caacgccaag
     6901 tcgcagcaga cgaagctggc gtgggacgcg gacaacaacg tcacgtacat ggaggagaac
     6961 aacggcgccg tcaccgccta ctgctacgac ccgctcaccg gctacccgct gtggaagcgc
     7021 accgcggagc acaacaaggg cggggtcccg ccgcagagcg actgcgcacc cggcaagtac
     7081 cccgccgact cgcagaagtt cgagtacgtc aagcgactgg acggctactc ctccgacctc
     7141 tcccgcaaga cctctccgga gggccgcgcc tggcagttcg gctatgactc cttcggcaac
     7201 ctgaagacgg tcaccgaccc gaagggcgtc gcgacgccca ccgcgggcga ctacacgacc
     7261 gcctacgagt acgacacgta cggccagctg accaaggcca ccgacgccaa cggccacgcc
     7321 acggtcaaca gcgccttcac gccgaccggc tacccggcca agatcacgga cgccctcggc
     7381 aacagcatcg gctacgagta cgacgtgcgc ggcaaggtca ccaagacgac cgacccgctg
     7441 ggcagccgca ccacgcagac gtacgacacg tacggcaggc cgctggtcag gacggcgccg
     7501 agggaccagg ccgcgggtga tctcatcacc gtcccggcac ccgactacga cgccaacgac
     7561 aacgtcacca aggcgatcgc gcccaccggt gccgtgtcca cggcggtcta cgacgcggcc
     7621 gaccagctca ccgaggccac ctcgccgcag gacacgccga ccgcgccgct gcgccggacg
     7681 gtctacacct acgacaagac cggccacctg aagaccacga ccgagccgaa gggcgtggcc
     7741 acgtccggca tcccggacga ctacaccacc acccagaact acgacgagat ctaccagctc
     7801 gcctccgtgg tcaacgccct cggcgagaag atcacgtaca cgtacgacga ggtgggcaac
     7861 aacgtcaagg tcgtcgaccc gaagaagaac cggacggccg accccgacga cttctcgtcg
     7921 aagatgacct acgacctgga gcaccgggtc acctcggtca ccgacccgct gggcaacgtg
     7981 acgcgccgcg cctacgacaa ggacgcgctg gtcgtcgccg acacggaccc cgacggcaac
     8041 accacctact ccggctacga cgagcggggc cgcaagaccg agcagcgggt tccgcactcg
     8101 ggctccggca ccggcatcac ctaccgcacc acccgctacg agtacgacca ggtcggcaac
     8161 gccacccggg tcgtcacccc gcgcggcacg gagaccgcga acgccgacga cttcaccagt
     8221 cgtaccgagt acgacgagct gaaccggccg gtcaagcagt acctgccgta cgacccggcg
     8281 gacgcccgct acaacaagcc gaacgtctac acgcagacgt tctacgacgc ggccggccgc
     8341 gtcacgcgga cctcgcagcc gccctccgag ggccagaccg tccgcaacga caccgagtac
     8401 acctactacg acaacgggtg gaccaagagc tccaccgacc cgtgggacat caagacgagc
     8461 tacgagtaca acgacctggg gctgcagacc tccaggacgc tcagctcggc cggcgggtcc
     8521 gtcagccgca ccatgggctg gagctactac cccaacggca agctgaagga gaagaccgac
     8581 gacggcgtgc ccgtcggcac cgccgtgccg ctcgtcgaca actccgacgc ccagaacacc
     8641 ggttccaccg gcacctggac cacggcgagc ctcacggggc agcagggctt cgaccaccgc
     8701 gtgcacgcgg ccggagccgg gacggacgcg tactcctgga cgctgaacat ccctaagaac
     8761 ggcaagtaca ccgcgtacgt gaagttcccg caggtcgcgg gcgccagcaa gaccgccaag
     8821 tacaaggtca cgcacggcgc cggcagcacc gaccgcacgg tcgaccagtc caccgcggcg
     8881 ggcacctggg tcagcctcgg cacgtacgac ttcacccagg gcaacgcggc gaagctggaa
     8941 ctgttccagg ccacggacgg caaggtcgtg gccgacgggg tcaagctggt gcgcgacctc
     9001 accggcgaca tcgacgcgga gaagcaccac ttccgctacg cctacgacct gaacgacaac
     9061 ctctcgctga tcgacgacct gtcgtccggc gccgaggtcg acgcgtacac gatctcctac
     9121 accggtctga accgggtgtc cggcatcacc gagaccctgg ccggccagca gaagaccagt
     9181 acgtcctaca cctacgacgc caacgaccag cccgagagca tcacccaccc cgaccagtac
     9241 tcgaagtaca cctacgacct gcgggagaag gtcaaggcgg tctcggtggg cacctcgccc
     9301 acggacaccg accccaaggt cacctcgtac acctacaccg accgcggtga gtccctgcgg
     9361 gagaccaagg acaacggcaa caccgtcgac ttcgagtact tcctcgacgg cgcggtcagg
     9421 accagcgccg agaagaaggc cgacggcacg ctcgtcgcct cgcacaccta cgcctacgac
     9481 gccaacggca acaaggcgca ggacgcggcg aagaagatga acgccgacaa ccacgcggcg
     9541 tacctcgaat ccaccaccgc ctacacctac gacccggtcg accggatcgc caagtcggtg
     9601 aagaccggca acggcgccgc caccgagacg tacgtccacg acgacaacgc caacgtcgtc
     9661 cagcagaacg tcggcggcac cgccaccgac ttccgctacg accgcaaccg gctccagacg
     9721 tcgaccagcg cgggatccgt cacctccttc aactacgacc cgctgggtcg tcaggagtcg
     9781 acgtcccagg gcgggcagat cgtctcgcgc agcatctacg acggcttcga ccacgtcgtc
     9841 gagtcccagc agcgggacgg caccggcgcg atgaagtcga cgaagtacac cttcgacccg
     9901 ctcgaccgca cctcgtcgaa gaccgcggac ggcaagacca ccgactaccg ctacctcggc
     9961 ctctcccagg aggtgctgac cgaggaggtg gccggcaagc tcaccaagtc ctaccagtac
    10021 agcccgtggg gccagcgtct ctcccaggtc aagcacaacg agaacgggac gaccgaggac
    10081 gcctactacg gctacaacag ccacaccgac gtcgagacgc tgaccgacgc caccggcaac
    10141 accaaggcca cctacggcta cacggcctac ggcaacgacg actcgtcgga gttcaccggc
    10201 atcgacaagc cggacgcctc cgacccgacg aaggaggagt acaactccta ccgctacagc
    10261 gccaagcggt gggacgccgg gtccggtacg tacgacatgg gcttccgtga ctacgacccg
    10321 gggctgaacc aacggggccc tggccgacat gggcctgggc agcgacccct tcaccggcaa
    10381 ccgctacgcc ttcaccggcg gcaacccgat cagcaacgtc gagatcgacg gccactggtt
    10441 cgccctcgcg atcccggcgg tcgccgtggc cttcgtcgcg gcggtcgtgg tggtcgtcgc
    10501 cgtcatcgcc gtcgccgcgg ccgtcgagta cgtcgtcaac gaggtccggg accggatcga
    10561 cgaggccaac cggtcgcgtg acgacaccgc cgacgagccc gcacccgacc cgcggcgcgt
    10621 tccgcggccg cagcccgagc ccgacaacga cgacgacgac aagtcgggtt gcggcgacgg
    10681 ctggatcaag tacggcgacc gggacgcggc caacggcaac cgggccacgg ccgccgaggc
    10741 ctgcctgacc aaggagtacc tgaagaacaa caagggaacc ggcgtgggtt ccaaccctcc
    10801 gggatacgag tgggcgcagg actacgccaa gggcaagggg ctcgacgcgc agaagaacgt
    10861 caacgcgtgc cacctcatcg gcaacaagct ggcgggcaag ggagtcctgg cgaacctctc
    10921 cccgtgcgct cgcggcgcca acgccaagca gatcggctcc acgcagggcg acgaccacat
    10981 gaggacgtac gaactgcagg tctacaacgc cgtgatggcg ggccaggacg tcatgtactc
    11041 cgtgtccccc cgctacgacg gcaaccggac ggtgccgacc ggttacgaca tctcggcgta
    11101 cggcgtgaat cccgacggtt cggtcgggat cgacttccag gtgttcatcc cgaacacact
    11161 gagcacagga gacaatctcg gcacacagag cgacaacggt tcgccggtac ccacagggag
    11221 cacaccatga cggggaccgc gaccgaccgc acggaccgca cggaaacgga acgaggcacc
    11281 gatgagtgag ccgaccgacc tcgacgcgct gcgccggctg atgccgccgc cgcaggacgg
    11341 ggacacgacg gtcgactgga ccgccctggc cacgtcgtgg ggcaagccct tcccggacga
    11401 cttccgccgc ttcatggagg tctacggggc cggcgcggtg cagaactacc tgtcgatcgg
    11461 caggccggag gccaaggtgc cgctggagca ggccgagcgc gacggcatgg tgatcgagac
    11521 ggcgaacgcc gaggccgact gggagacgga ggagaagact cccgagcttg agggcacctc
    11581 tccggagctg atcacctggg gggtctccgc caccgcggac atgctgtgct gggacgcgtc
    11641 gaacgacgat cccgccaagt ggcccgtcgt ggtctaccac cgcaacgaca tgctgtggag
    11701 ccgctacgac tgcgggatgg tggagttcct cgtccggaac ttccgtgccg agtggccgga
    11761 gaaccccctg ggcggcgagt tcctctggga cgtgagcgag gtgacgttcc aggcacaggg
    11821 ctgacgcccc gcagtgtgca cgagacgctc ggccgggtct tccggccgag cgtttcgcgt
    11881 gagcggcggt cgccggtgtt cacgcacgaa gtcgaaaggc cggcggctta ctcggcgatc
    11941 tccgtacgct cccaccactc gtacacccga agggtgccct ccttggtgtc gtgtcggtgt
    12001 ggggtctccc tgaagtgctc gtatccgcct cgatgcggga tcttcacgtc ctcgccggga
    12061 atctcgaccg tgacgatccg ctcagggagg tcttccggcc cgccttccag agataccttg
    12121 tgtgccatga caccagtgtc gccaccctcg gcgcgcatcg cacccgggag gcgccgccag
    12181 gacccaccac cgcgagcgcc gacggccact cgccgcaggc gcaccgtgga gggcgagcga
    12241 gccgcccagg cgcagagaac ggcaagggcg gccagggcgt acgccgtcgt gcccgcgccg
    12301 tggacggcac ggccggtgac ataggcgccc gcgcccgcga gggcgacggc gagccattcc
    12361 cagcggccgt cgagggccac cagggcaacc aggagcaggg cgtaccagga gtagccgggg
    12421 gtcgtcagga ggaaggcggt tccggtgacc aggagtgccc cgctccacgg acgcccggcg
    12481 tcgccgcggc ggatcacgta caggctcacg gcgagcatgc ccgcgagcac ggcgggaagc
    12541 gcccaggcgt cgggcagcac ccagcgcagg agggcgtaac ggccgccgga ggaggcgtcc
    12601 tggtagccct cctcctcggc gtagccgccg agatagccca tgacggaatg gcgggaggcc
    12661 cagacgtacg ggaggtagag cgcggcgagg accgcggcgg cgggcaccag ggtcgccgcg
    12721 gcgggacgcg ggcggtgtac gccggacagg gcgccgggga tgaggacggc gggcaggagt
    12781 ttgacagcgg tggccaggcc caggagggct cctccgaggg cacggtgccg gaccgtcagt
    12841 ccgagggcgg cgacggagag caggaccgcg aggacatcgg cgtgggcgtt gttgacggcc
    12901 tcgacgggga cggccgggca ccaggcccag taggcggcgg tgcgcgggtc gcctcggcga
    12961 cgcaggatcc gcagcaggac cacggtggtg gcgaccgcga gggcggcccc accggtctgg
    13021 agggccttgt gccggacgcc gtcgggggaa acggtgtggg cgaggaggaa gtagagttcg
    13081 ccggccgggg ggtagacggt gtggacccgg gggcggttga cgcgggtgca gacaccgtcg
    13141 gcgacggggg cgagatccgg cttgccgcag gcggcgcccg tgggaaagag ccaggtgtcg
    13201 cggaggtggg cgagggcggg gtcggccggg gcgtggtcgt agggcgagcc gccggctgct
    13261 tggacccggc cgtcccaggc atagcggaac gagtcggtgc tggtccgggg aggtgcgacc
    13321 agaccggtga cggccactgc gacgcctccg gcgagcacga gagcggcgac gtgccgggcg
    13381 ggtgtcctcc gcaggttcca gaccgcggcc gagaagagca cccagcagat ggcgtaccac
    13441 caggagagac ccgccgggtc ggcgaagtag ccgtccttgc ggaccgtgag gacgagcgcg
    13501 gaggcgagcg cggccagcag cacggcggtg accgccgtgc tgcgggtgcc ggtggtgggc
    13561 ggctgggtca cgccgtcacc ctggcaggag acgggccgtc gcgggcggtg gcgcggcagg
    13621 gcgtccgcgt ttcgtaaggt gtcggaccgc ccccgcgacc cgtcgagccg gttgcatggg
    13681 cgcatgggat ctcgaatcgg ccggcgcctg cgcgtcccgg ccttccgact gcccgcgccg
    13741 ccgccacgcc tgaccgccct ccgcccaccg gccttctcgg ggcggctcca cgatccgcgc
    13801 accgccacgg cgatcggacg gtggctcggc gtggcactcg ccgtgtgctt cctgacgggg
    13861 ctgatcagtc acttcctgca gaacccgccg ggctggctgg ccggctacct gccgtcgcgg
    13921 ccggtgtggg ggtaccggct gacccagggg ctgcacgtcg gcgtggggct ggcggcgatc
    13981 gtgctgcttc cggcgaagct gtgggcggtc tacccccggc tgttcgtgtg gccgccggtc
    14041 cggtcggtca cgcacggact ggagcggctg tcggtggccg tgctggtggc ctcgggcgtg
    14101 ttccaggtac tgacggggct gctgaacatc gccgagtggt atccgtggcc gttctccttc
    14161 gtccccgtcc actacgcggt cgcctggatc gtcgccgggt ccgtgctgtt gcacctcgct
    14221 gtcaaggcac ccgagatccg cgcccactgg ggcaggcgct ccgcgggcac gctcgccctt
    14281 cccgacgcgg aacgggacgg cccggaccgg cgggcgctgc tgatcggggt gggttcggcc
    14341 gtcggcgccg tgaccgtcac gacggtgggc cagtccttca ccccgctggc gtccctcgat
    14401 ctgctggcgc ctcgccaccc ggggtacggg ccgcagggtc tgccggtcaa ccggaccgct
    14461 gccgccgccg gggtgaccga ggacgggctg cggggctggt acctggaagt gctcggaccg
    14521 gctccgttcc ggctgacgct ggacgagctc agggccctgc cgcaggctgg ggcgcggctg
    14581 ccgatcgcct gtgtggaggg ctggagcgtg gacgcccggt ggagcggcgt ccggatccgg
    14641 gacctgatgg ctcgggcggg agccctgccg ggctccgggc tgcgagtggt gtcgctcgag
    14701 gtgcggggcg cgtaccgggt gatggagatg ggccgggagt acgcgcaaga cccgctgacg
    14761 ctgttggccc tgcggctgaa cggcgaggtg ctgtcggcgg accacggcca tccggcgcgg
    14821 atcatcgcgc cgaaccggcc gggtgtgctg cagaccaagt gggtcacacg gctggaggtg
    14881 ctgtgaagtc cgagcccggg gcggagtccg agcccgagcc cggggcggag tccgtgcccg
    14941 agcctggggc ggagtccgag cccgagcccg actccgagcc cgagccggtg tccgggcccg
    15001 tgtcggcggt gcgttacgcg ctgggcgtgc tgggactgct gctcatcggc atcgggggct
    15061 ggcacctgtc gtcccaaccc gacccttatg acgtcctggt gtggctgggc ggggcgctgg
    15121 tgctgcacga cggggtgatc gcgccgctgg tgctggccgt cggactgctg gtcgcggcgg
    15181 taccggcgcg tcgcgtggtg cgcggcgcgc tcgtcaccgg cggggcgctg gtgctggtca
    15241 cgctgccgct gctgctgcgg ccgggggtcc cgcccaaccc ctccgcgctg cccctgccgt
    15301 acgcgcggaa cctgctgctc gtcctcgcgg tggtcaccgg tgtcacggtg gtctgggtgg
    15361 gcctgacccg gctgcggtgg cggggcacgc cgggcgtacg ggacaagcgg gccgtgtctt
    15421 ccgaagtcgg ctccggggca ccggagggcc gggggccggg cgctcaggcg ccgccggaag
    15481 actgagcacc gggtacgaga gcggcgcggg gccgtccagg cgtgcgtgac cgcccggccc
    15541 gcccgggccg cgtggcggag cagggcctcg gggtcgcccc ggggccacgg aaaggacgtg
    15601 ccgagcccgc cccgcccgtc gtccagccgt acctcgcagc gctcgtccgc ctcgacgccg
    15661 gaggctgtca gccgcccggc cggaggctgt cagccgcccg ccgagggcag gagcccggcg
    15721 gtcaggcgct ggtgcaggac cccgaaacgc ccggccggtg cctgggcggc gacctcgtgg
    15781 gcgtcgtcgg cggtgtccac gtcccggaga accggcagga gcccggcgcg caacccggcc
    15841 gcccgcaacc gcccgtactg aacggccccg gtctccggtg cggacatggg cacgccgagc
    15901 agcagcgccg ggtcgggcac cgccaggccc agggcccaga acccgccgtc ggcggcccgc
    15961 ccgaaccagg cgtcgtaccg gccgaactcc agtgcggggg tgaggagtcc gggcgtgacc
    16021 tgtggggtgt ccataccgat gagcagcgct gggccggtgc accctgcgaa ggcggcggcg
    16081 aggcgctcgt cgaggccccc gacgccttgg ggcaccacct cgaagccggg tgggagccac
    16141 ggcccggggg cgccgtcgag taccaggacg tgccggtcgg caggggtggc ggccaccgcc
    16201 gtcagggtgt cggcgagggc cgcttcggcc agggccgccg cctcctcggg ggtgaacggc
    16261 ggggtgaggc gggtcttcac gcgtccgggc gatggctgct tggcgatcac gagcaggctg
    16321 gtcaccgcgc acccccggac cgcccggccg cggtggcgta cggaggttcg gcgaggaccg
    16381 cgcgcatgtc gcggaccgcg tgccaggtgc cccgccaggt gccggtgacc ttggacttcc
    16441 cggcccgggg caggtacggc acgtcctcct ccctgacccg ccagcccgcg tcggcggccc
    16501 gtaccaccat ctggagcgga tagccgctgc gcctgtcggt caggtcaagg cccagcaggg
    16561 cctcgcggcg ggccgcccgc aggggtccga ggtcgcgcaa ccgcaacccg gtccggcggc
    16621 gcagcatccg ggacagggcg tggttcccgg cacgggcgtg cagcggccag gccccccggc
    16681 cctgggttcg gcggcggccg agcacgaggt cggcccggtc cgcggcgacg gtccgtacga
    16741 agccggtcag caggccgggg tcgagggagg cgtcgcagtc gcagaagcag acgtactcgg
    16801 cctcggcggc cagcagtccg gcgtggcagg cggcgccgaa gccgcgccgg gactccgcca
    16861 ccacggtggc gccgagggag cgggcgagct cggccgaacc gtcggtggac ccgttgtcca
    16921 ccaccagggc ccgccagccg gcggggatgc gggcgaggac ccagggcagg gcctcggcct
    16981 cgttcagaca gggaaggacg acgtccacgg tgtcttggct cacgcctgcc accgtaggaa
    17041 ctcccggcgg acggagcggg catcgactcc ccacggaaca cggacgtcga ccgtttcgac
    17101 cagcgcgacg ggaccgccgt accgtccgtg accgacggcc gcggcgccgt ccgcgaggag
    17161 ggtcaccctg ccgcccgccg acgcccacgc cagacggacg gacgggcgga cgggcggaac
    17221 ggcgctacgc caccccggtc gatgcccgct gtccggcgcg ggcgaactcc gccatgccct
    17281 caccgaagcc cacctggggg cgccagcccg actcacggcg cagccgggac gagtccgccg
    17341 tgatgtgccg tacgtcgccc agccggaact cccccgtcac cagcggcgcg ggcccgccgt
    17401 gcgccgccgc cagctccgcc gccatctcgc cgacggtgtg cgggtctccg ctcccgacgt
    17461 tgtagacggt gtggcccccg ggcggctggc ctgcgaggcc tgccagcgcg gccgcgttcg
    17521 ccccggccac gtcccggacg tggacgaagt cccggcgctg cgcgccgtcc tcgaacaccc
    17581 ggggcgcctc tcccctggcc agcgccgacc ggaagaacga cgccacgccc gcgtaggggg
    17641 tgtcccgggg catcccgggc ccgtacacgt tgtggtagcg cagcgacacc gcggtccccc
    17701 cgacggaccg ggcccaggcc gcggccaggt tctcctgggc cagtttcgtc gtcgcgtagg
    17761 cgttccgggg atcagcgggg gcgtcctcgt ccaccagccc gggcgcgagc tccgccccgc
    17821 acaccgggca gcacggttcg aaccggcccg cccgcaggtc ctcgaccgcc cggggcccgg
    17881 gccgcaccac accgtgctct cggcaaccat cgaccccgcc tgcaccaggg cgcgtacccc
    17941 ggtctccgcc atgccggcca gcagcaccgc cgtacccagg tcattgcagg acacgtaggc
    18001 gggcgcgtcc gcgaagtcct tccccagacc gaccatggcc gcctggtggc acacggcgtc
    18061 cacatcgcgc agggcggccc ggaccgtgcc cgggtctctc acatcgcccc gaacgaactc
    18121 ggcgtccggc agttccggtt cgacggcatg ggcggcgggc agcagggcgt ccagcaccac
    18181 cggctcgtgc ccctcggccg ccagtgcggc gacgacgtgc gagccgatga acccggctcc
    18241 tcctgtgacg agtacgcgca tggcgcgcac gctacggaat ccggcccggc acccgtggtt
    18301 cccgcaccgg gccgcgaggc atccgtcgtc acccgcccgg agacggttga cggtcagggg
    18361 ccgccggtcg gagtcggccg agccccgccg cgcgcaccgg gcggccaccg gcgggcgatg
    18421 ggagaatggg gacgggagga ccgcccggag ggaggcgccc cgtgaacgcg acccaggcgc
    18481 gccctgtcgc tggcacggcg gtcgtcgtcg gcgcgagcat ggcgggcttg tgcgcggccc
    18541 gtgtcctctc ggaacgcttc cggaacgtcg tggtgatcga tcgcgacacc ctgccgcgga
    18601 gcccgcagtg gcgttcccac gtaccgcagg gccgacagcc ccaccttctg ctctactccg
    18661 gtgcccagct gctggagcgc tggttcccgg ggatcgacga ggagctctgc aaaggtggag
    18721 cgaccgagtt cgacatctgt cgtgacttct actggcacca gggcggcggt ccgttggccc
    18781 ggcccccgag caccatgcac ggccccgtga tgtcgcgccc cttcctggag gagaccgtcc
    18841 gccgacgcgt gacggagctg cccgaggtca tcgtgaggga cggcaccgcg gtcgtgggtg
    18901 tggtcgccga cgacgcgggc cggcgcgtca tcggagtccg gttgtccgac ggttccgccc
    18961 tcgtctgcga tctgctggtc gacgccacgg gccggcaggc caggagtctg ggctggctca
    19021 aggaactggg ctacgccggg ccacccgtct cccacgtcgc cgtcgacacc cactacgcca
    19081 gccggaccta ccgccgcgaa gcgctgcccc cacgcgactg gaaggcggcc gcggtcatcg
    19141 gcgcccccga gaccaggcgc ctggcggtgg cgctgccgtg ggagggcggg cggtggatcg
    19201 tgggcctggt cggcgtcaac ggcgaactgc cgccgacgga cgaggcaggc agaatcgcct
    19261 tcgcacgctc cctcggctca ccggtcatcg ccgagctcat ggaggcatcg gagcccttgg
    19321 gcgaacccgt ggcctaccgc ttcgcggcca atcagcggcg ccatgtcgag aagatgcgcc
    19381 actacccact gggctgggtc ctgatcgggg acgcggtgtg cagtctcgac ccgatctacg
    19441 gtcagggcat gagcaccgcc gcccagcagg ccgcggctct cgcggactgc ctggaccgct
    19501 ccagcggcat cgaccgtacc ttcacccgca gctacttcca cgcagcgacg aggccggtgg
    19561 ccagggcctg gtcgatcacg gtcggcgggg acttcgcgta cgcgggcacc accggcagca
    19621 agccgccggg tacggacctt ctcaaccggt acatggcacg ggtcaacatc gcggcccagc
    19681 acgacgcgac ggtctgtatc cgcttcagcg aagtcgccgg cctgatccgg cgtcccgagt
    19741 ggttgctcac tcccgcgttc gtgctgcgcg tgctgcgctt cgcacgccgt ggtcccgccg
    19801 gtgagcatcc tgcgcccgcg tctgccggaa cgcaggcggc gtaggacgga tcaccgctgc
    19861 ttcgcgaccg gccgcaccgc ctgcggagcc gccacggcga acgcgtctcg ggggcgaccg
    19921 acggacggat attttccggt gtgccgcccc gggactcgcc cctgccaggc gagctgtggc
    19981 gtcgggcagg ggcgaagggg tcaggtgccg aggtgggcgc ggatcgccga cgccagttcg
    20041 gcgacgccgt gctccttcag gacgctgtag tggtcgccgt ccaggtcgac gatggtgggg
    20101 ggagccgcgg agtagccggt tcggccctcg atgaacgagt agtcgtcccc cgaggccttg
    20161 aggatggtca ccggggcgtc gaggcgccgt tcggccagct cgcggaagct gtactcgaac
    20221 tcgtacgtct cgccgacgat ccgcgtgatc ctgcggatca gtcgcttgtc caggaccggg
    20281 agcagatcgt gtacgaacga cacgaagccg tcctcgtcct gcgctgccgt gaggcaccgt
    20341 gccagctcgg gcccgctgac ggacccggcg aagacggaga acaggatcgt gaggtacgcc
    20401 ggattgcggt acgaggcctc gcgtccgtgg cggtcgccgt cggcctcgcg gaccttcggg
    20461 ttcccggggc agatcagcag caggtcgtcg acctgttcgc cggcctgctc cagctgccag
    20521 gcggcttcga aggcgacccg ggcgccgaag gagtaccccc acagcgtgta cggcccctcg
    20581 ggccgcaggc gtcggatctc cgtcacgtcg gctgcggcca tctcccggat cgtggggtag
    20641 ggcgtctctc cggcgttgat gccgtgggcc tgcacgccgt agaacggccg gccggctccc
    20701 gcctcgcgtc ccaggaggcg gaggttcatc gggtatccgc ccagtccggg ccagcagaac
    20761 accgggctgc cggcgccctc gtcgtgcaac gggaccagtc gtgaggacgg cgcgctgtcg
    20821 ccgctgtcga tccggtgcgc gagctcggcc agcttcgggt gctcgaagac gacctggagc
    20881 ggcagccgcg taccgaactc cttgttgatc cggttgatga gcgcgacggc gctcagcgag
    20941 tttccgccgg aggcgaagaa ctcgtcctcc accgacacgt tctcgtactt cagcgccttc
    21001 ccccacgcct cggcgagcca tcgttcggct cgggtcgagg gtgcgacgta cgggctgccg
    21061 gtatccgccg acgtcacctc ctcggaggcg gccagggcct tggcgtcgac cttcccgttc
    21121 gcggtcagcg ggagttcgtc caccaccaga acccggctcg ggatcatgta gtcgggcagg
    21181 agcccggcca gctcatcctt gatgatctcc gccggaccct tcatgtggac cgtgtcctcg
    21241 tacatgcctt cgctgcggat ctgctcctcg ctgaccctgc cgccgaggaa gaagtacgac
    21301 gcgccgggcc cgatgccgca cgaggccagg atgtcgtcga cgcgccgcgc cgccggcagc
    21361 ggatggccgg acttcgagct gtagccggac gacatgaagc ccaggccgag gccgttgcgc
    21421 tgcaggtggt gaagtttcgt ccccaggctg atgtactcca gccacggctg gtccgcccgg
    21481 ctgaccgcgg tgacgccgag gctcgcccgc tcgtacacct tctggttgat ggcgatcacg
    21541 tgcttgcgca gcaccagatc gtccgacagg cgttccaact cgccgtccgc gtagcggtac
    21601 tggcccgtcg gcagtccctc cacccgtccg gggtgggcct gcacgtagat ctcggtgggg
    21661 tcctgccggg gtgccccgtc gcaggggtgg atcgcgaacg tgcccaggta gtggtcctcg
    21721 tccgcgacgt ccaggcggct cttgacggac gggcggaagg ccagcgggct gatgtccagc
    21781 ccgtactcgg gcagcacctc ctcgaacagg cccaccatgt gtccggcctc gaactccagc
    21841 acctcctgga tgttgttctt gtacaccggc tggatcgccc gcttcttgcc gacgaagtgc
    21901 gccgacagcc aggcgccgga gccggtcgcg gccgggccga tccgcaccag ggtgtggtcc
    21961 acgggatggt agtagtacac cccggagtcc aggccgtgga taccgccggt ctccaggtac
    22021 agctgggtcg cgtacagcgc gccgggggaa gcgtaggcgt acttcggcag aagccgctcg
    22081 tcactccgga agcggccgaa ccaccggagc atctccccga gttcggcgaa cgtcacctcg
    22141 tcgaggccgc gggagaagtc gccgacccgc cgaggggcga ggagctccag cacgtcggac
    22201 cgggtgacgt tcccgccctc gtagaagcgg taggtcttgc gcgcgaaggt ttcccgccgc
    22261 tggcccgggg actcctgctt gccgggcagc tccgtcaccg gcctgtcgtg cagctcctcg
    22321 gggtccctca ggcccgggtt ggacaactgg gccttcacct gcagcttgct ggccttggac
    22381 cggtggtgac ctccgtggtt gccctggtcc atcagggccg cttccttcgg gttcagctcg
    22441 atgcacgcga cgaggttctg gaagccggtc ctcgtgtcgt cggtgacgac ggccgcggcc
    22501 cgtctcaccc aggtgtgctc ctcgatggcc agggcgatct cgtcgagttc gacgcggtag
    22561 ccgcgcagct tgatctggtt gtccgcccgg ccggagaact ggatggtgcc gtccgggttc
    22621 cagtacgcca ggtcgccggt cctgtacagc cgttccgtcg gcacgaacgg ggaggggacg
    22681 aaccgttccc tcgactggtc gggccggtgc aggtagccgc gcgccagctg gacgcctccg
    22741 atgtacagct caccggtctc cccgatgtcg accggcgcca ggtcctcgtc gaggatgaag
    22801 cactgggtgt tgtcgacggg cacgccgatc gggatcgtgc cggggccttc gccgatctcg
    22861 tccgggtcga cgaggtgggc ggtcgcgttg atggtgcact cggtcggccc gtagaggttc
    22921 accagggacg cccacggaac ctcgtcggcg aaggtccgtg ccagttgccg cgagagcgcc
    22981 tctccgccgg agaacacccg tctcagggtg gtgcagaggg tgaagtcgtc ggtgtccagc
    23041 agcgcctgga gcaaggtggg cacgcactgg agcgtggtca cctcgtgctt cacgatcgtc
    23101 tcggccagtg cctggggatc ccggtagacg cctggggcgc ccatgacgac ccggccgccc
    23161 atcgcgggcg ccaggatctc ccactgggcc gcgtcgaaac tcatcggcgt cttctgcagc
    23221 accgtggtgc ccttgcccac gtgcccgcag gagtgcatcc agcgcatctg ggacgcgatg
    23281 ccgcggtgct cgatcatcac acccttcggc ctgcccgtgc tgcccgaggt gtagatgacg
    23341 tacgccaacg cgtcgggccg gggaggcggc gcacccgccc cggtgttccg ctcttgggtg
    23401 acgacccgcg tgccggaagg ggcgagctcg gccaggcggt ccgccaggtg gtcctgggtg
    23461 acgacgacgc gggtccggct gtcctcgatc atgtagcgca gccggtcctc ggggtactcc
    23521 ggggacagcg gcagataggc cgccccggcg aacagaatgc cccacgcccc ggccatcagg
    23581 tccagggacg gctcgacgta cagaccgacg cagtcgtcgg cgcccacacc caggcggcgc
    23641 agggaggcgg ccagtccgct ggccgcctgt acgagttccc ggtaggtgag gctctggtcg
    23701 tcgcaggcga ccgcgacggc ctcgggctgt gcttccgcct gctcccggag gaggtcggtc
    23761 aggcaactgc ccagatgggc agtgtgtatg cgtgcgttga gcggtgcggt cttcacggct
    23821 tccccctgcc ggccggtgcg tgctgacgag acatgagtga cggacccccg gtgccggccc
    23881 gggcattccg ctccggccgg ggctgggcca ggacgacggc gacgacgacg gccatggcac
    23941 cggccgcctg gagcaccgac aacttctggt ccaggaaggc gtatccgagg agcgtcgcgg
    24001 ccaaggggct ggcgaagccc aggaccgaca ccgccagcgc gggcagccgt ccgatgcccc
    24061 ggaaccagat cgcgtaggcg aacagggccc cgatcacgct caagtacgcg aacccggtga
    24121 tgttcgtgcc cgtgatctcg ccgggcaagc cctcggcgac cagcatgacc ggcgccagca
    24181 caaggccgcc cacggtcaac tgccagccgg tgaacgtcag gacgcccacg ccctccgggc
    24241 ggccccagcg tttggtgagc acgatgccgg aggccatgct gaccgcaccc gccagcccgg
    24301 cgaggacgcc cacgctgtcc agacccgccc gcggctgcag gaccagcagc gccacgccca
    24361 acacgccgag cacgcaagcc gccagctgca cccgctggat ccgctccttc agcagcagcg
    24421 ccccgagcag cagcaccagc atgggctgaa ccccgggcag gtggtaggcg gccacgaaca
    24481 gcaggtagaa gaacgcgccg atgttcaaca cgcccagggc cgaggcacgc caccaccaca
    24541 cgccgcgcgg cagtacgcgt ccgatcgcga gcagcacgag cccggcgggc agggcccgca
    24601 cggtggaggc cagcaacggc ctgtcggcgg gcagcagttc cgtcgtcacc aggtaggtac
    24661 tgccccagac cgccggagcc agcgcggtca gggccgagtc gaacgccggc ctgccgccct
    24721 tcatgcgacg cccggggcga ggaggcacga gacggatgaa gcggcaggaa atatgacggt
    24781 atgtaacgct atgtgcacga tgagttctcc tgtgtgggca gggctgtgcg ccgaagaagc
    24841 gacgcggtga gggtgtgggc aggggtcgct acgccttgat gcgcagcggc ccctgcttga
    24901 aaggagggaa gaagcggaag cggctgccca cccggtcgcg gtgggctccg tccgtgtccg
    24961 ccgaagggcg cacacggcga gatcccggga ggccgacggc tcccggtcgc atgcccgggg
    25021 cggcggcgag cggagcgccg gcccgaatcc gtaaacggcc attcgaacac cgaagttgac
    25081 acagcccgtc cgcggcagtc acccctcggc tatctgccta tggcgggcgc tgcccggtgc
    25141 tcgcgtcagc ctgtcctcgc ggtgacggcc gacggcgtga ccgctgcggg agacccgtgc
    25201 aacaccggca cccgcgccgt ggcgccctgc ccgtcaccga cggagttccg cggcgccgat
    25261 acggccgggg caagcgggct gggggcgatg gactgcacca ctgcggacct ccttggggaa
    25321 cacgcgtccc gttcgatgga gcatgtgcga cgacgcgggg tctgactcgc cgacagccgc
    25381 tcctccgtgg aggcagcggc cttggcacac agtggcgcga ccgtgccggg atctcaccgg
    25441 gcttccgcac gccgtcgctt gacgccgaaa aaataccgcg cggcacttcc cttcggccag
    25501 ggccgacggg agcgctgttg atcacactca tgacgacgca cgcgtccgtg cgggagagct
    25561 gctgtggacg gtgtcctggg cgacgcggga gcaccgggtg aggggccgga gacgcgcgca
    25621 cgaggagggc gggaagcgtg ggggcttccc gcctcccgcg acctaggatc accgggacgc
    25681 aggacggcgg acgagacacg ggagaggcgg cggacgtggc ggacgagcgc gtgta
//
