LOCUS       NZ_JH792251            25238 bp    DNA     linear   CON 15-MAR-2024
DEFINITION  Bacillus mycoides strain VD078 supercont1.1, whole genome shotgun
            sequence.
ACCESSION   NZ_JH792251
VERSION     NZ_JH792251.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus mycoides (Bacillus weihenstephanensis)
  ORGANISM  Bacillus mycoides
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5172041)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Young,S.K.,
            Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B., Abouelleil,A.,
            Alvarado,L., Arachchi,H.M., Berlin,A., Chapman,S.B., Goldberg,J.,
            Griggs,A., Gujja,S., Hansen,M., Howarth,C., Imamovic,A., Larimer,J.,
            McCowen,C., Montmayeur,A., Murphy,C., Neiman,D., Pearson,M.,
            Priest,M., Roberts,A., Saif,S., Shea,T., Sisk,P., Sykes,S.,
            Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Bacillus cereus VD078
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5172041)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Young,S.K.,
            Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B., Abouelleil,A.,
            Alvarado,L., Arachchi,H.M., Berlin,A., Chapman,S.B., Goldberg,J.,
            Griggs,A., Gujja,S., Hansen,M., Howarth,C., Imamovic,A., Larimer,J.,
            McCowen,C., Montmayeur,A., Murphy,C., Neiman,D., Pearson,M.,
            Priest,M., Roberts,A., Saif,S., Shea,T., Sisk,P., Sykes,S.,
            Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (05-APR-2012) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000290895.1
            Current Name                      :: Bacillus mycoides
            Previous Name                     :: Bacillus cereus VD078
            Date Updated                      :: 2018-06-08
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_000003925.1
            A1 Name                           :: Bacillus mycoides
            A1 ANI                            :: 98.66715%
            A1 Query Coverage                 :: 80.95%
            A1 Subject Coverage               :: 88.35%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_002014665.1
            A2 Name                           :: Bacillus cereus VD078
            A2 ANI                            :: 89.90313%
            A2 Query Coverage                 :: 68.38%
            A2 Subject Coverage               :: 77.02%
            ##Taxonomic-Update-Statistics-END##
            ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R38749
            Assembly Name                     :: Baci_cere_VD078_V1
            Genome Coverage                   :: 146.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000290895.1-RS_2024_03_15
            Annotation Date                   :: 03/15/2024 02:24:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,225
            CDSs (total)                      :: 6,127
            Genes (coding)                    :: 5,875
            CDSs (with protein)               :: 5,875
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 3, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 3, 3 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1 (5S, 23S)
            tRNAs                             :: 79
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 252
            CDSs (without protein)            :: 252
            Pseudo Genes (ambiguous residues) :: 0 of 252
            Pseudo Genes (frameshifted)       :: 92 of 252
            Pseudo Genes (incomplete)         :: 158 of 252
            Pseudo Genes (internal stop)      :: 71 of 252
            Pseudo Genes (multiple problems)  :: 58 of 252
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:24:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2843214
            Orig. end                         :: 2868452
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JH792251.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The organism was changed from 'Bacillus cereus VD078' to 'Bacillus
            mycoides' in June 2018.
FEATURES             Location/Qualifiers
     region          1..25238
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="7"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25238
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25238
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15238](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15238)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(211..819)
                     /gene="yqeK"
                     /locus_tag="III_RS14495"
                     /old_locus_tag="III_02920"
     CDS             complement(211..819)
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966604.1"
                     /locus_tag="III_RS14495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02920"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_002168331.1"
                     /transl_table=11
                     /translation="MLYNDIYSFTPTGKIENDIKAFLLKYNKEFTYKHSIRVANEARKI
                     AGIFYEDEEKAAIAGCLHDISAIFPNEERIAVAEEFGIEILQEEREFPMIIHQKLSSVI
                     AKEIFKIEDEEVLNAISCHTTLHKHATKMDLVLFIADKLEWDQIGTPSYLIEVKKGLEK
                     SLEHAAFVYISYLWERKYTLKVIHPWLEEAYWYLKEIVE"
     gene            1017..1712
                     /locus_tag="III_RS14500"
                     /old_locus_tag="III_02921"
     CDS             1017..1712
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="III_RS14500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02921"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002016575.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKDIVELLAVYLRNEGYNIYKAYDGDEALQMICTY
                     EVDLMLLDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            1702..2859
                     /locus_tag="III_RS14505"
                     /old_locus_tag="III_02922"
     CDS             1702..2859
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127015.1"
                     /locus_tag="III_RS14505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02922"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_002168332.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIFRLVTSVIES
                     SLTLSELGKEFIRIFGHEKYIGLKESLWMMIVSYLFLFSIFSSYLYIFYRHERKVYYET
                     CIKKMIEEIRYIASGNFNHKVSIVHHNYLEELATGVNQIIEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSAPIDIVELLGQLTVQFRIQLQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINTITYGNDGDHIDITAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKLLPYKA"
     gene            3041..4057
                     /locus_tag="III_RS14510"
                     /old_locus_tag="III_02923"
     CDS             3041..4057
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="III_RS14510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02923"
                     /product="serine hydrolase"
                     /protein_id="WP_002127502.1"
                     /transl_table=11
                     /translation="MQFLKKITVLLLSFLITALIVLYFYLYVNGPIIQAKSAILIDTNS
                     GEIVYKKNEETPIQSATLSKLMTEYIALEQLNEGKIQLDELVKISNEVFRAETSPIQVT
                     SKDKTTVRDLLHALFLTGNNRSALALAEHIAGNEDNFTLLMNDKAKQLKLSQPSPFLNA
                     TGINNDTNKQSTTTSIDVAKLATQLVKDFPDVLNVTKLTSYQFTFKDSKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNGNYSFVSTATRGDTRLISVILDAGDENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWTILFQFKNLIIQMIMIFFIITILMFLYIRQKKTEDFN"
     gene            complement(4116..>4349)
                     /locus_tag="III_RS14515"
                     /old_locus_tag="III_02924"
                     /pseudo=""
     CDS             complement(4116..>4349)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="III_RS14515"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="III_02924"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="KSLSDLYRRELDNFLQLWSGDFESKILKASWTDKTYKYGEVLRHV
                     IVHEIHHIGQISIWARELNLQPVSANLIGRGL"
     gene            complement(4370..4930)
                     /locus_tag="III_RS14520"
                     /old_locus_tag="III_02925"
     CDS             complement(4370..4930)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127500.1"
                     /locus_tag="III_RS14520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02925"
                     /product="hypothetical protein"
                     /protein_id="WP_002168334.1"
                     /transl_table=11
                     /translation="MNKKTKIISIAAVSGGGKTTITESLAHELKNSKALYFDRYKFDNC
                     PVDICKWIDDGANYDEWVLTPLMNDIQRSIQDSSLDYIIVDYPFAYLNREVGQFIDVTI
                     FIDTPLDIAMARRILRDFKEDTMSEIHNNLKHYMTHARKAYLEAIHTVKPNSDIVLDGS
                     LSISEIIDQIIEELNRREVIVNG"
     gene            complement(4977..5492)
                     /locus_tag="III_RS14525"
                     /old_locus_tag="III_02926"
     CDS             complement(4977..5492)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002168335.1"
                     /locus_tag="III_RS14525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02926"
                     /product="GNAT family protein"
                     /protein_id="WP_002168335.1"
                     /transl_table=11
                     /translation="MIKLKQFTRTDFKQLINWINSEEFLIQWSGNAFTYPLNEQQLEKY
                     TECANTLAFKIMDEETKAVIGHISLGQIDNINKSARIGKVLVGNTKMRGRSIGKHMMKA
                     VLCIAFDELKLHRVTLGVYDFNKSAISCYEKIGFVKEGLLRESKRVGETYWNLWEMSML
                     EYEWNNKK"
     gene            complement(5617..5973)
                     /locus_tag="III_RS14530"
                     /old_locus_tag="III_02927"
     CDS             complement(5617..5973)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002032241.1"
                     /locus_tag="III_RS14530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02927"
                     /product="hypothetical protein"
                     /protein_id="WP_002032241.1"
                     /transl_table=11
                     /translation="MGSRFNNCRKKCTCKHDDCWDIFEECKKEKNEKCDSSCVQGIRDE
                     LKKLINKTVRINTEGRTYIGTVSSVTCDVVKLAAIPGSVAAIISLCKIEAILPPATTVT
                     DEFDFNGVDVANKD"
     gene            6435..6737
                     /locus_tag="III_RS14535"
                     /old_locus_tag="III_02928"
     CDS             6435..6737
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="III_RS14535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="III_02928"
                     /product="hypothetical protein"
                     /protein_id="WP_170935234.1"
                     /transl_table=11
                     /translation="MKGGIKECPGKMIAGVLRKSIVVMTGGNLKKRIIVMMIGVLRKSI
                     VMMIGGNLKKRIIVIMIGVLNEISVVVNVSLFVVIVKEKVGNIFNIDLKERTCLL"
     gene            complement(6845..7225)
                     /locus_tag="III_RS14540"
                     /old_locus_tag="III_02929"
     CDS             complement(6845..7225)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="III_RS14540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02929"
                     /product="hypothetical protein"
                     /protein_id="WP_002168336.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGSIILHNVWVFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRVLS
                     TRIALAIIGALALWMLIVIYIK"
     misc_feature    7334..7347
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(7335..7348)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            complement(7392..7562)
                     /locus_tag="III_RS33570"
     CDS             complement(7392..7562)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000284255.1"
                     /locus_tag="III_RS33570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_003189371.1"
                     /transl_table=11
                     /translation="MYQGDHFITEGIILEVSEKANKSLYWRWCMLAPRYEKVCGNSTKR
                     LRLIRIDDDEE"
     gene            7892..8260
                     /locus_tag="III_RS14545"
                     /old_locus_tag="III_02930"
     CDS             7892..8260
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="III_RS14545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02930"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_002168337.1"
                     /transl_table=11
                     /translation="MGNIPKISSQQSNPKIPSQQVNANTKQGNNKKTRRRIITTLAFIL
                     PIIFVLQYSLNNQQEMIKEKQITVNTEQQKLSSLKKDGHSLKNDVKALTGSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     gene            8459..>8515
                     /locus_tag="III_RS33955"
                     /pseudo=""
     CDS             8459..>8515
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="III_RS33955"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLYFAALNPGSIGPTL"
     gene            complement(8533..8781)
                     /locus_tag="III_RS33960"
                     /old_locus_tag="III_02931"
     CDS             complement(8533..8781)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="III_RS33960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02931"
                     /product="hypothetical protein"
                     /protein_id="WP_002168338.1"
                     /transl_table=11
                     /translation="MVSLEVKVIEAGPAGRLNPVGPVGPVGPVGPVEPVDPVDPVGPVE
                     PVDPVDPVDPVGPVGPVEPVDPVEPVAPVEPVGPVGN"
     misc_feature    complement(8790..8807)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            complement(8827..9042)
                     /locus_tag="III_RS33965"
                     /old_locus_tag="III_02932"
     CDS             complement(8827..9042)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237376.1"
                     /locus_tag="III_RS33965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02932"
                     /product="hypothetical protein"
                     /protein_id="WP_002168339.1"
                     /transl_table=11
                     /translation="MVIVTLAIVPGESRSEAVTFTVPGPLAARNTAVKLPEALVMTARG
                     TMKAREGLLNEKLTTTPGVGLPFTNT"
     gene            9360..9557
                     /locus_tag="III_RS14560"
                     /old_locus_tag="III_02933"
     CDS             9360..9557
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002017016.1"
                     /locus_tag="III_RS14560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02933"
                     /product="hypothetical protein"
                     /protein_id="WP_002017016.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDPVSLDALNTPSKAQEQLQETSQEAHNSNKKDST
                     QALHGEDLPISDVYRTTNKQ"
     gene            complement(10001..11941)
                     /locus_tag="III_RS14565"
                     /old_locus_tag="III_02934"
     CDS             complement(10001..11941)
                     /NRPS_PKS="Domain: AMP-binding (95-521). E-value: 2.4e-82.
                     Score: 268.6. Matches aSDomain:
                     nrpspksdomains_III_RS14565_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="III_RS14565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02934"
                     /product="AMP-binding protein"
                     /protein_id="WP_002168340.1"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-87, bitscore:
                     291.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLFGWMKSLGYEDYEAFYNKSIEETAWFW
                     GEAERAVGYQWMKPYTEVLDLENGTPFAQWYTEGTCNVVESALSRWLADDKTKTQAALM
                     YEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNNVIEAAAIGVPDDVKGEVCHCFVVLRDGVIFTAELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     CDS_motif       complement(10346..10408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_III_RS14565_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="III_RS14565"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     aSDomain        complement(10379..11656)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_III_RS14565_AMP-binding.1"
                     /evalue="2.40E-82"
                     /label="III_RS14565_AMP-binding.1"
                     /locus_tag="III_RS14565"
                     /protein_end="521"
                     /protein_start="95"
                     /score="268.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KTKTQAALMYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGD
                     RVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRR
                     GKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNS
                     DDPLMLIYTSGTTGKPKGTVHTHAGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPF
                     LLFGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNK
                     HSLKSLEVFASTGEPWNPDPWMWLFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAP
                     ISFNASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFEN
                     KWVHGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       complement(11099..11155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_III_RS14565_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="III_RS14565"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     gene            complement(11990..13531)
                     /locus_tag="III_RS14570"
                     /old_locus_tag="III_02935"
     CDS             complement(11990..13531)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="III_RS14570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02935"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_002168341.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLVYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLITPQEPKQFDKTLEEIIPENQNAPFNM
                     KDLINRIIDEGSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYRLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            complement(13534..14322)
                     /locus_tag="III_RS14575"
                     /old_locus_tag="III_02936"
     CDS             complement(13534..14322)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 4.4e-75. Score:
                     244.1. Matches aSDomain: nrpspksdomains_III_RS14575_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="III_RS14575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02936"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_002017012.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRERQANSLSLALLEELQTILTQI
                     NEESNTRVVILTGDGEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRKPMYKGE"
     aSDomain        complement(13561..14280)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_III_RS14575_ECH.1"
                     /evalue="4.40E-75"
                     /label="III_RS14575_ECH.1"
                     /locus_tag="III_RS14575"
                     /protein_end="254"
                     /protein_start="14"
                     /score="244.1"
                     /tool="antismash"
                     /translation="HVVKISLNRERQANSLSLALLEELQTILTQINEESNTRVVILTGD
                     GEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            complement(14327..15238)
                     /gene="mvaB"
                     /locus_tag="III_RS14580"
                     /old_locus_tag="III_02937"
     CDS             complement(14327..15238)
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="III_RS14580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02937"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_002168342.1"
                     /sec_met_domain="HMGL-like (E-value: 4.5e-49, bitscore:
                     165.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADASDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALAVIEDITKQATFEGKKVRGYVSTVFGCPYEGDISATAVDEIC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKRYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            complement(15260..15475)
                     /locus_tag="III_RS14585"
                     /old_locus_tag="III_02938"
     CDS             complement(15260..15475)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="III_RS14585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02938"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001985297.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     misc_feature    complement(15499..15515)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 25.24"
                     /tool="antismash"
     gene            complement(15502..16839)
                     /locus_tag="III_RS14590"
                     /old_locus_tag="III_02939"
     CDS             complement(15502..16839)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="III_RS14590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02939"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_002017008.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.6e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.4e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.8e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.5e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKLA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPTNIRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LKIALEELKIEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     gene            complement(16855..18000)
                     /locus_tag="III_RS14595"
                     /old_locus_tag="III_02940"
     CDS             complement(16855..18000)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="III_RS14595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02940"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_002032227.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.2e-39, bitscore:
                     131.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.7e-26, bitscore:
                     89.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-57, bitscore:
                     192.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTLSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKFLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGFEDNGKKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKPISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERYIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            complement(18217..19185)
                     /locus_tag="III_RS14600"
                     /old_locus_tag="III_02941"
     CDS             complement(18217..19185)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="III_RS14600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02941"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_002127490.1"
                     /transl_table=11
                     /translation="MRQFAKPIIVVSKCLEFDACRYNGEMVPDLTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEKNGANRLVQPSIREDVTEKMNEFSNAFLQTLPEVDGFILKN
                     RSPSCGTRDVKIYSGFEKGPVKGKGTGLFGGAVIKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAHYKMIKHTKNIKELVAFQSDYKYLFMAYNQVKQKELGRIIANQKNETIEVVFD
                     NYEKTLYELFIRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLELLQKYSEKKIPLSSL
                     LVILKTWAIRFDEKYLLRQTYFEPYPEGLVEISDSGKGRDY"
     gene            complement(19190..19843)
                     /locus_tag="III_RS14605"
                     /old_locus_tag="III_02942"
     CDS             complement(19190..19843)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="III_RS14605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02942"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002032224.1"
                     /transl_table=11
                     /translation="MKKDWLEELVAATNADKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLFAVVMPTLTKFAAPFFVQAFAKEIFKTEYESYEVLL
                     RVIIQNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLIETELLVHFKKLIAKFQEEGE
                     IIELPPSSVLRLTLSAVLGLLLTRFLLLPEEKWDDEVEIENTIQFILYGLTPRR"
     gene            complement(19868..20887)
                     /locus_tag="III_RS14610"
                     /old_locus_tag="III_02943"
     CDS             complement(19868..20887)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="III_RS14610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02943"
                     /product="ABC transporter permease"
                     /protein_id="WP_002127488.1"
                     /transl_table=11
                     /translation="MRVNGVVIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLIFTQKDYI
                     PHIAVVDVPAPIVKAMKNQEASIYEYSKDKAISELEKQKVDAVIHLENGKMNLLLEGSD
                     SSKNRAVLQVLQKSTEKNNVSMMKPEVDYLHGSKDITMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVLGYIIGFGIFALIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQVFFSGLFPMESMNTW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            complement(20884..21609)
                     /locus_tag="III_RS14615"
                     /old_locus_tag="III_02944"
     CDS             complement(20884..21609)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129461.1"
                     /locus_tag="III_RS14615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02944"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002168343.1"
                     /transl_table=11
                     /translation="MQQPSIILRDVSKKFGEKEVLHNLSLQVEKAEIFGLVGPSGSGKT
                     TLIKMIAGINESTTGDVIVFNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKERIVEVFELLQLSEHTKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKSIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAIGTPEELKK
                     QTSSGRIEDVFMLEGVIES"
     gene            complement(21794..22045)
                     /locus_tag="III_RS14620"
                     /old_locus_tag="III_02945"
     CDS             complement(21794..22045)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="III_RS14620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02945"
                     /product="hypothetical protein"
                     /protein_id="WP_002017002.1"
                     /transl_table=11
                     /translation="MHKEFEIEEYTAIEEQIHYYSTSLLVSHPEQIVKYLEKRLEKYAE
                     TLQYAHLYPETVILPIQQIVIEYSLDVARIRRYLNLKT"
     gene            complement(22262..23104)
                     /locus_tag="III_RS14625"
                     /old_locus_tag="III_02946"
     CDS             complement(22262..23104)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="III_RS14625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02946"
                     /product="metallophosphoesterase"
                     /protein_id="WP_002032218.1"
                     /sec_met_domain="Metallophos_2 (E-value: 6.9e-09, bitscore:
                     34.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIKRIILIIGILVGISIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKVKSINPDIIAITGDLIDSKSYDAEMSMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKKLKKQHVTVLRNEHVIIQKGGHEINLLGIDDPEF
                     NTGDIDEGSIVKDAIVKAKIETLPDRYNVLLSHRPEFLEAYADEQVDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGILPKYTAGLYEQQNTSMIVSRGLGNSIIPQRVFNRPEIVVVQLN"
     misc_feature    complement(23149..23167)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.89"
                     /tool="antismash"
     misc_feature    23242..23257
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    complement(23365..23378)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            23705..24274
                     /locus_tag="III_RS14630"
                     /old_locus_tag="III_02947"
     CDS             23705..24274
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="III_RS14630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="III_02947"
                     /product="hypothetical protein"
                     /protein_id="WP_002127485.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPSTSVFAAEKEAPIQQEETQMSI
                     QPFAQNNLETAVKAALNGPEVKKIKVFEHEFNVKPIEVVNLGGGKTYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFTAPLLSILAAYNGIPVNPNDLNALGQQ
                     IGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    complement(24473..24486)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.02"
                     /tool="antismash"
ORIGIN
        1 aatatatctt taaatagact tttattatac ctatatagtt gtgtaaaata ttccatatta
       61 tacgtgttac catcttcttt gaattgatat ttatctttcc caaaatcaag atgaagatga
      121 ttttcccact gaaagtatat ggacggtact aacgtaactc ctgggaatgt ttgattcata
      181 tattctttta attgcatttt tatacccttt ctactctaca atttctttta aataccaata
      241 tgcttcttct aaccacgggt gtatgacttt taatgtatat tttctttccc acaaatatga
      301 aatatataca aaagcagcat gttccaaaga tttttccaat ccttttttta cctcaattaa
      361 atatgacggt gtccctattt gatcccattc taatttatca gcaataaata atactaaatc
      421 catcttcgtt gcatgtttat gcaacgtagt gtggcaactg attgcattta aaacttcttc
      481 atcctctatt ttgaatatct cttttgcaat tacactcgat aatttttgat gaataatcat
      541 tggaaactct cgttcttctt gtaatatttc tatgccaaat tcttcagcaa ctgcaatccg
      601 ctcctcattc ggaaagattg cactaatatc atgtaaacac cctgcaatcg ctgctttttc
      661 ttcatcttca taaaatattc ccgcaatttt tctcgcctca tttgccacac gaattgaatg
      721 tttatatgta aattctttat tgtattttaa tagaaaagct ttaatatcat tttctatttt
      781 tccagttgga gtaaatgaat atatatcatt atataacata gcaagtcccc cttataacta
      841 tctttcagta taatgtggag tttaaatatc cttcttattt tatattcgtt atgaatgttt
      901 taattccttt ttaatacgat acatgcaatt ttatgtagaa acattactac aaaatacata
      961 aatgtttgat attatagtaa tgttgattaa ttgtaaggaa aggaactaac tataaaatga
     1021 ataaaaacat attaattatt gatgatgata aagatattgt agaattactg gctgtttatt
     1081 tacgaaatga aggctataac atttataaag cttatgatgg tgatgaagca ttacaaatga
     1141 tatgtacata tgaagttgac cttatgcttt tagatattat gatgccaaaa cgaaacggat
     1201 tggaagtttg tcaagaagtg cgtgaaaata atactgtacc tatccttatg cttagtgcaa
     1261 aggctgaaga tatggataaa attttaggac ttatgaccgg cgcagatgat tatatgatta
     1321 aaccgtttaa tccactagaa ttagtggcta gagtgaaagc tttattacga agatcctctt
     1381 tccaaaatgc tacttcccaa aagaatgaag atggtattat tcgtattcgt tctgttgaaa
     1441 tacataaaca taatcatact gttaaagtaa atggagaata tattaaactc acctctatcg
     1501 aatttgatat tttatattta ctagcgagta atactggaag agtatttagc tctgaagaga
     1561 tattcgaacg agtttggaat gaagacggtt atggttctaa taaaacggta atggtccata
     1621 ttagtaattt acgcgataaa cttgaaaccg taatgaatgg tgaaaaacta attcatacgg
     1681 tttggggagt aggatataaa attgagaaat gaagcatttg atatattaaa agatatacca
     1741 aagtggaagc ttattttttg gcttttatta gctatcactc ttacaccaat taccgaatta
     1801 attatatttc gcctcgtaac gagtgtaatt gagagttcac ttactctaag cgaactagga
     1861 aaagaattca ttagaatttt tggccatgaa aaatatattg gattaaaaga gtctttatgg
     1921 atgatgattg tatcttattt gtttttattt tctattttct catcctattt atacattttt
     1981 tatcgtcatg aaagaaaggt ttactatgaa acttgtataa aaaaaatgat tgaagagatt
     2041 cggtatattg caagtggaaa ctttaatcat aaagtttcca tcgtacacca taattattta
     2101 gaagaactgg caactggggt caatcaaatt attgagcaat taaaagtttc gattgatgaa
     2161 gaaagacagg cagaacaagc aaaaagcgaa cttattacaa atgtatcaca tgacttacga
     2221 acccctctta catctatagt tggatacgta aatttaatcc atcatgataa ttatagagat
     2281 gaagtagaat tacgatacta tattcaagtc atttacgata aagtaactcg tcttaatgca
     2341 ttaatgaatg acttgtttga atatacacgc gttcaaaata aagagttaag tttatattct
     2401 gctcccattg atattgtaga attgcttgga caattaactg tccaatttcg gatacagctt
     2461 caagaagcta atattgaatg tcgcccttct ttcccatctc aaaagctaat ggtactagct
     2521 gatggggata aattagtacg tgtgtttgaa aatctaatca taaacactat tacttatgga
     2581 aatgatggag atcatattga tattaccgct tacgaaagca ataacatgat tacaattgat
     2641 ataacaaatt acggacaacc tatccctagt actgatttac ctcatatttt tgaacgtttt
     2701 tatcgtgttg aaaaatcacg ttcaacaaac actggtggat ctgggctcgg attagcaatt
     2761 gcaaaaagta ttgttgaatt gcataaagga acaattgaag tatatagcga tgataaaaaa
     2821 acaactttca ctgtaaaatt actcccttat aaagcttaat accacatatt tataggttca
     2881 attttttatc atataaaaaa ttgaaccttt tatattccat caatatccaa aatttaataa
     2941 tcctttataa ttctttagaa attctttacc ttttctttct tcctaattaa gcattccttt
     3001 ttacaataat attattgatg taatattagg aggatcgcta atgcaattct taaaaaaaat
     3061 aacagtttta ttattatctt ttcttattac tgcacttatc gttttatatt tttatcttta
     3121 tgtaaatggt ccaattattc aagctaaatc agctatttta atagatacta attctggtga
     3181 gattgtttat aaaaaaaatg aagaaactcc tatacaatca gctactttat ctaaattaat
     3241 gacagagtat atcgcactgg aacaactgaa tgaaggaaaa atacagttag atgaattagt
     3301 aaaaataagt aacgaagttt tccgagcaga aacgagtcct atacaagtaa cttcgaaaga
     3361 taaaacgacg gttcgtgatt tacttcatgc attgtttttg acagggaata atcgttccgc
     3421 acttgccctt gcagaacaca ttgctggaaa cgaagataac tttacacttt taatgaatga
     3481 caaagcaaaa caactaaagt tatcacaacc atccccgttt ctaaatgcta ctggaattaa
     3541 taacgatacg aataaacaat caactacaac atcgatagac gtcgctaaac tagcaacaca
     3601 attagtaaaa gactttccag atgtattgaa tgttacgaaa ctaacctctt accaatttac
     3661 cttcaaagat tcaaaagttt tcaatacaaa taaaatgata tattccctta ataaaaacat
     3721 taaactccaa ggtgttgacg gcttacaaac tagtttttca actaatggta attatagttt
     3781 tgtcagtaca gccacacgag gagatactag acttatttca gtaatattag acgccggtga
     3841 tgaaaacagt acttttattg aaacaaaaaa gttacttcag tacggttttg atccttcctc
     3901 gtactctgca ctccaagctt ttaaagatgc tgttacatct tggacaatat tgtttcagtt
     3961 taaaaattta atcatacaaa tgattatgat ctttttcatc attacaatct taatgttttt
     4021 atatatacgt caaaaaaaaa ccgaggattt taattaagaa atcttcttat atataaaaac
     4081 cgacttgcgt ttacactgca agtcggtttc taaatctaca atcctcttcc aattaaattc
     4141 gctgaaacgg gctgaagatt tagttctctt gcccatatag atatctgacc aatatgatga
     4201 atttcatgta caattacatg ccttaaaact tcaccgtatt tatatgtttt atctgtccat
     4261 gaagctttca atatttttga ttcgaagtcg ccagaccata actgcaaaaa gttatctaat
     4321 tctcgtctat ataaatcaga taatgacttg tacatatcgt tttatacatt taaccattca
     4381 caatcacttc tcttcgatta agttcctcta ttatttgatc aattatttca cttatagata
     4441 aagatccatc caatacaata tccgaattcg gcttaacagt atgaattgcc tctaaataag
     4501 cttttctcgc atgtgtcatg taatgtttca aattattgtg tatttcactc attgtatctt
     4561 ctttaaaatc tctcaaaatt cttctagcca tcgcaatatc taaaggtgta tcgataaata
     4621 tagttacatc aatgaattgt cccacctctc tatttaagta tgcaaaagga taatctacaa
     4681 taatataatc taaactacta tcttgtatag aacgctgaat atcattcatt agcggtgtaa
     4741 gtacccattc atcgtaatta gctccatcat caatccattt gcaaatatca accggacagt
     4801 tatcaaattt atatctatca aaatatagag cctttgagtt tttcaactca tgagctaaac
     4861 tttctgtaat ggtagtttta ccgccccctg aaacagctgc aattgaaatt atttttgttt
     4921 ttttattcac gattcccacc aaaccacttt tgttaacata atataattat aaaatactat
     4981 tttttattgt tccattcata ttctaacata ctcatttccc ataaattcca atacgtttct
     5041 cctactcttt ttgactctct taataaacct tcttttacaa aacctatttt ttcgtaacaa
     5101 gaaatagctg acttattaaa gtcataaaca ccaagagtta ctctatgtag ttttaattca
     5161 tcaaaagcaa tacaaagtac ggctttcatc atatgtttcc ctatagaacg ccctctcatt
     5221 ttcgtattac caactagcac ttttccaatt ctagcagact tatttatatt atctatttgt
     5281 ccaagagaaa tatgaccaat aactgcttta gtctcttcat ccattatttt gaatgccagt
     5341 gtgtttgcac attctgtata tttctctaat tgctgttcat ttaaaggata tgtgaatgca
     5401 tttcccgacc attgtattaa aaattcttcg gaattaatcc aatttattaa ttgtttgaaa
     5461 tcagttcttg taaattgttt cagcttgatc actctcattc tcctttcaca caacctttta
     5521 tacaccttca aatttatttc tatatgaaaa atatattccc ttttaaacaa aataaaaagc
     5581 cattcataag aatggcttag catcaataaa gcataattaa tctttatttg ctacgtcaac
     5641 accgttaaaa tcaaactcat cagtaacagt tgtagcaggt ggtaaaattg cttcaatttt
     5701 acaaagagat ataattgctg caactgaacc gggaatagca gctagcttaa caacatcgca
     5761 agttaccgaa gaaacagtac ctatataagt acgtccttca gtgttaattc gcactgtttt
     5821 attaattaat tttttaagct catctctaat tccttgtaca caagagctgt cacatttctc
     5881 attcttttcc tttttacact cttcaaaaat gtcccaacaa tcatcatgct tacacgtaca
     5941 tttctttcta caattattaa atcgagaacc caaaacttca ccccctaatc ctttctacta
     6001 gtaaagtatg tccaatagct taaaagtgta cgagacaaaa gcatagaaac aaaaaaacaa
     6061 acacttgtac taaaccttct tatttatact tttaataagc cggctccttg aatagggacc
     6121 accttttcct attacttcac atatacatag gctttgttcg cagtgatatg gtgtattttt
     6181 cctttaccat tgtgaaatat acattcagaa aagcgtactc caaaataaga tattatttaa
     6241 aatcttaacg tttccttcaa caagtgtttg ttgattaata tcataaccag tagttctctc
     6301 aactatctct tgaaaattag catagtttgt atgaattcta tatctagtag aaagcactct
     6361 atcatataaa ggtaaaataa taggttaata aacaagccat tcttttacta aaacatagaa
     6421 tagtatgaat cctattgaag ggaggtataa aagaatgtcc tggaaaaatg attgctggag
     6481 ttctaagaaa aagcattgtt gtgatgactg gtggaaatct aaagaaaaga atcattgtga
     6541 tgatgattgg agttctaagg aaaagcattg taatgatgat tggtggaaat ctaaagaaaa
     6601 gaatcattgt gataatgatt ggagttctaa acgaaataag tgtcgttgta aatgtttctt
     6661 tatttgttgt cattgtaaaa gaaaaagttg gtaacatttt caatatcgac ttaaaagaga
     6721 gaacatgtct tttgtgaccg ataaatacta gaatgtaata tacaaaaagc tgactaagta
     6781 tagtcagctt tttgtcaatg aacacgtaga gatttatttt aatatagttc ttattagaaa
     6841 atgattattt tatatagatt actataagca tccataaagc caaggcgcca atgatagcga
     6901 gcgctatacg tgtagatagt acccttaatt caaagtctgt tttcttggag ggttcaggat
     6961 atgcaattat gtagattccc tttaataatg caagccatgc aataaccgtt aggaacccct
     7021 gccagttgaa tacccataca ttatgtagga ttatactacc taaccctagg aaaatcgata
     7081 gaaaaccata cataatacca aatcctctgt cttcaaccac taattttttc aattcacgta
     7141 gtaccgatgg acgtacgaaa agtattcccg atacgataac cgttatccat ccccaaaaca
     7201 atcctaaaaa agtactagtt tccattatta gttcactccc ctcaattatt tatattccag
     7261 atattccccc ctttagaaca attccaacat ctttatatat aggctaaatt ctgctctttt
     7321 ttaatacaaa catggcatat tctatgccca tccttaatca cctcatttct ctacaaaatg
     7381 aaatttttat atcattcttc atcatcatct atccgaatca accgaagtcg ctttgtacta
     7441 ttaccgcaca ctttttcata tcttggagct aacatgcacc aacgccaata taatgattta
     7501 ttcgcctttt cactaacctc taaaattatc ccctctgtaa taaaatgatc accttgatac
     7561 aatgtatact cgcttgtccc atggaatcat cattattccc ctccctatta aaatagcgtt
     7621 tttgtttcaa ataatgctct cattaatttg gacgcattta ccagtatatt taccaaaaaa
     7681 ttcatgatat cgttaactag tcgagtacgt cattacttga cgattaccct taggagcccc
     7741 gcagacaatc ggggttcctt ttatttaaat aaggattttg tttaaacttt acaaaactca
     7801 cctatattaa actatcttct agaattccca ttgaacattt ataatacttt taaacagttt
     7861 aaattctaca atcagtaatg gaggcatttt aatgggaaac atcccaaaaa tatcatcaca
     7921 acaatcaaat cctaagatac cctcacagca agtgaacgct aacaccaaac aaggtaataa
     7981 taaaaaaaca agacgccgta ttataactac tttagctttt atattaccta taatttttgt
     8041 ccttcaatat tctcttaata accagcaaga aatgattaaa gaaaaacaaa tcacggttaa
     8101 tacggagcaa caaaaattat cttctttaaa gaaggatggt cattccctta aaaatgatgt
     8161 taaggcttta acaggtagtg aagaagaaat tttaaaattc gcaaggaaac tgtatggatt
     8221 ttccaaaccg aatgaaacta tatttcaaat aactgaataa aattacactg cattacccca
     8281 aaaggcgatt tgacgataat cgccttttta tatttaattt ctaaaataaa catactaatt
     8341 tctttttcta tcaaataact attttgttta atttattaaa atacaaccgc ttgtccattt
     8401 cacattgctc tatcattaca tttactatta gtaatacgat ttttagaggt gataaataat
     8461 ggacgagttt ttatattttg ctgcacttaa tccgggttct attggaccta cacttccacc
     8521 tgttcaaccc tttcaattcc ctactggtcc caccggttct acaggagcta ctggctcaac
     8581 cggatcaact ggttctaccg gaccaactgg accaaccgga tcaaccggat caaccggatc
     8641 aactggttct accggaccaa ccggatcaac cggatcaact ggttctaccg gaccaactgg
     8701 accaactgga ccaactggac caactggatt taatcttcct gctgggcctg cctctattac
     8761 cttgacttct aacgaaacca cagcatgtgt atccactcaa ggaaataata ctttattttt
     8821 ttcgggtcaa gtattagtaa acggtagtcc tactccagga gtagtggtca gtttttcatt
     8881 cagtaaccct tctcttgctt tcatggttcc tcttgcggtc attaccaatg cttcaggtaa
     8941 ctttaccgct gtatttctag ccgctaatgg gcctggaaca gtaaacgtta ctgcttcact
     9001 tcttgattct cctggaacaa tggctagcgt cactattacc attgtgaatt gtccgtaatg
     9061 gttttatttt taaggactaa gcaatatcta ataagatgag cactgattta cagtgctctt
     9121 ttttatcatt gggatgttcc tttcaaatga aatttcgtaa caccctacta aaataacgct
     9181 tttattaaga actaatgatc tttatatttc ttaagcttgt catcacaagt aatttttata
     9241 attagttaaa ttctcaatat agtttgtgta tataattcca ttcaaagata cataataccc
     9301 acgtaactat ttaaaaatac tttgttttta tatctaagtt caaaaaggag ctacataaca
     9361 tggataaaaa agatttatta agtcaacaac ttgatcctgt gtcattagat gcgctgaata
     9421 cccctagtaa ggcccaagaa caactgcaag aaacatctca ggaggcacat aattcaaaca
     9481 aaaaggacag tactcaagct ttacatggcg aagatttacc aatttcagat gtatatagaa
     9541 caacgaacaa acagtaaatt taaaagggaa aaaatcttaa gaacgagtga acttaattct
     9601 tttccctttt cctatttaaa taacactttt atatgaaacc cgtacacatt tttgacacat
     9661 ccactatcac aatctcctga aaattcgtga taatattaat ttgtcggata cgccaaattt
     9721 cgacattgaa cgacaataat atctccctta ttgaatccct gtcccccagg gatttctcct
     9781 tttattcatt acttttttct tcactaaatt ttcattctta acaaaattca ttcactccat
     9841 tgaatagaca gccacagtat cctattttga taaaaactaa aaacaaacag atatacttaa
     9901 cactaatagt agatttttta acttcaaatt tactttttct ctcttatctt tttgtaaaca
     9961 ttaaaaatga gctctattta catagagctc attcgtaatt ttatagtttg ctagactgta
    10021 acccctgaat aaacggaact acttcaggat ttacaagtga cgataaatct cctaactctt
    10081 ttcctaagta agccgctttt atgacacgtc gcattacttt agaatttcgt gtttttggta
    10141 aatcttctac aacgtggatg tcttttggac ataaagcttt accaatatga gagtttacta
    10201 aactcattaa ttctttcttt aattctgctg taaatattac accgtctcgt aatactacaa
    10261 agcaatgaca aacctcacct ttaacatcgt caggtacacc aattgcagct gcttctatta
    10321 cattattatg tttcacaaga atagattcat attcagcagg tccaatacgt tttccagcaa
    10381 tgtttaacgt atcatctgaa cggcctgtaa tgatatattg ttcaccgtca taaatgaccc
    10441 agtcaccatg aacccactta ttttcaaaac gtgaccagta agtgtttaca taacgctcat
    10501 catcttccca gaaacttttc gtcataccta cccaaggttt ttctaaacat aattctccga
    10561 cttcatctcg aattggttta ccttgatcat caagtacaac cgctgccatt cctggtaaag
    10621 atgcgttaaa actaatcggt gcgatcggct taattaggac attcccgaaa atcccacctg
    10681 aaatttcagt tccacctgaa tagttacaaa ttggtacttt acctttacca actgtattaa
    10741 ataaccacat ccatgggtct ggattccaag gttctcctgt tgatgcgaat acttctaaac
    10801 tctttaacga gtgtttattt acatattcat caccttttgc cattaatgca cggattaatg
    10861 ttggtgaaat accgagatga gtaatttcat atttatcgac tgtctcccat aagcggtctg
    10921 cttctggaaa gtctgggaca ccttcataca taaccattgt tgcgccatta attaaagagc
    10981 cgaatagtaa aaatggtccc atcatccagc ccatatcagt tacccataat actcggtcgc
    11041 cttgttttat attcattcca aatcctgcat caaatgcaga ttttagcggg aaaccagcat
    11101 gtgtgtgtac tgtccccttc ggcttaccag tcgttccaga tgtatatata agcattaatg
    11161 gatcatcact gttcatttct tcagcatgta taaatggttt ttctttttct aacgtactcc
    11221 atgaaaaatc ataattatgt ggtgtaaaat catttcctgc atgacgaaca attaccacct
    11281 tttcaacagt tggacaatgt tcacaagctt tatctacttc atcttttaat gaaacaattt
    11341 tcccacggcg tgaaaagcca tctgcggtaa taaccatttt tgaaccagct gcttgtacac
    11401 gtgtcattac tgcatcagca gcaaaacctg agaatattgg tgaaataatc gctccaattt
    11461 tcattaccgc taacatagca acaactgttt caggaatcat tggcatgtaa attgttacac
    11521 gatcaccttt ttcaatacca gcatgtttca aaccgttggc aacacggctt acccagctgt
    11581 caagctcttc atatgtaaat gatttcgaag ttccgttttc cccttcatac ataagtgctg
    11641 cttgtgtttt cgttttatcg tctgcaagcc agcgagataa agcagattct acaacgttac
    11701 aagttccctc agtataccac tgtgcaaacg gtgtaccatt ttctaaatct aacacttctg
    11761 tatatggttt catccactga tagccaactg ctctctcagc ttctccccaa aaccaagctg
    11821 tttcttcaat tgacttatta taaaaagctt cgtaatcttc atagcctaat gatttcatcc
    11881 aaccaaataa acgcgttttt tctttatatt cttctgttgg aaaccaaact gcttgtttca
    11941 tgttttcccc tccttgattt tttgagcaag aaagccctaa atagggcttt taaactggat
    12001 atacaggatg tttacgatcc gtgaatactt gatatttact catatacatt tcgaatcgtc
    12061 cttttagctc ttcacgtaaa ttgtttggat gaacaatacc atcaatcacc atctcagatg
    12121 ctaaacggta aatatcaata tctttcttat actcttctcg tttttcagca ataaagcttg
    12181 cacgctcttc ttctggtaaa gctgcaatct tatttgcata tacagcattg accgctgctt
    12241 ctggacccat tactgcaata gaagctgttg gtaatgctaa gcagcaatct ggttcaaacg
    12301 ctggacctgc cattgcatat aagccagctc catatgcttt tcgaacgacg atagaaattt
    12361 tcggtacagt tgcttcactc attgcagaga tcatttttgc accgtgacga ataattccgg
    12421 cacgttctac ttttgtacca atcataaatc caggtacatc tgcaaggaat aataatggaa
    12481 tatggtatgc atcgcataaa tttataaact tcgctgcttt atcagctgaa tcgtggaata
    12541 atacgccgcc cttcatacgc ggctgatttg caataatgcc aattggctta ccatcaatgc
    12601 gtgctaaacc tgtaattagt tcttgagcaa ataatttttt cacttcaaag aaagaacctt
    12661 catcaataat tctgttaatg agatctttca tattgaaagg agcattttga ttttctggaa
    12721 tgatttcttc taacgtttta tcgaactgtt tcggttcttg aggtgtaatc aaaggagtct
    12781 tttctaaata gttacttgga aaataagaaa tatattgtct tgcttgagta attgcatctt
    12841 cttctgtttt acataaaaca tctccgcatc ctgatactga gcaatgcata cgtgctccgc
    12901 ccatttcttc taaagttacc ttctcaccga taaccatttc agccatacgc ggagacccta
    12961 aatacataga agcatttcct tcaaccatca taacaacgtc acaaaatgct ggaatatacg
    13021 caccaccagc tgctgaaggt ccaaataata aacaaatttg tggcactttt ccagataatt
    13081 tcacttggtt ataaaaaatt cttcccgcac cgcggcgtcc agggaacatt tcaacttgat
    13141 ctgtaatacg cgctccagca gaatcaacta aataaactaa cggtacacgt aatttttctg
    13201 ctgtttcttg aattcgtaga attttttcaa ctgtacgtgc tccccatgat ccagctttta
    13261 cagtcgaatc atttgccatt acgcacgcag tacgaccatg tattttacca gtcgcagtta
    13321 caacaccatc agctggtaat ccagtttgtt cacaatttgc aaataatgca tcttccacat
    13381 attcaccatt atcgaataaa agagctaaac gatctcgaac aaaaagtttc ccttttgctt
    13441 tgttttgttc atgatatttc ggtgccccgc cttgcttaat tgtttcaact cgttcttcaa
    13501 atgaattaga ttgttgtttt tgatctaaca tatttactcc cccttataca ttggtttgcg
    13561 tttttccttg aatgcctgta atccttctaa tctatctttc gtatggatta cgccctcata
    13621 cgcctgtttt tccatttgta agccggtatg taaatctact tgaattccat ttgaaattgc
    13681 ttcttttgct aatcgaacag caattggacc atttttagca attcgatctg caatttcaat
    13741 tgctttctct tctagtaaat cagctggtac tacgaattct actaaaccat attctttcgc
    13801 ttcttgcgcc gaaatacgtc ttcctgtata aattaattct ttcgctctac cgactccaat
    13861 taatctcggt aaacgctgag taccacctgc tccaggtata attgcaagag aagtttcagt
    13921 aagacctaga cttgcagtgt cagaagcaat tctaaaatca caagctaagc ttaattcagt
    13981 acctccacca agtgcgattc cattaatagc agcaataact ggttgtggta attgttccac
    14041 catctccata gtagaacgaa tcatacccac agcatggcga acttgttctt cactcatgtt
    14101 ggcacgctct tttagatcag caccagcgca aaatgctttt tcgccatccc ctgttaaaat
    14161 aacaacgcgc gtatttgatt cttcgtttat ttgagttaat atagtttgta attcttctaa
    14221 taatgccaaa gataatgagt ttgcttgtct ttcacgattt aacgaaatct ttacaacgtg
    14281 cggtgtaaca tagtcaactg aaatgttttg taattgtagc atcttctcac ctacttatcg
    14341 ttttatgttg aagcgctcta tacacatgac tcggtaattg gatatttaac ttactttgaa
    14401 taaactgact agctctcaat aacttttctt catcaatatt agtttggact cccagcttat
    14461 ggagcatatg cactaagtca tcagtagcaa cattacccga tgctcctggt gcataaggac
    14521 atcctccgag tccaccacaa gaactatcaa acgttgtaat accatattct aaagacttaa
    14581 ctacattcgc cagagccatt ccatacgtat tatgaaaatg cattgcaaac tgcgaagcat
    14641 catacctctt taatagatgt tctaatactt gttctacttg taatggattc gctacaccaa
    14701 tcgtgtcacc gagagaaact tcataaatgc cgtatgaaaa tagttgatta catatttcgt
    14761 caactgctgt ggcacttata tccccttcat aaggacatcc aaatacagta gaaacatagc
    14821 ctcttacctt tttaccttcg aacgttgcct gttttgttat atcttcaatt acagctaatg
    14881 cttctttaat agatttatta atattacttt tattgtgaga ttcacttgct gataaaaaaa
    14941 cattcacctc atctacattt tgcaaaaaag ctcgttccaa accattttga tttggaacaa
    15001 gcgctgcata tgtaacattt ggatcccttt ttagctcaga aaatacatca cttgcatctg
    15061 ctaatgcagg aacccattta gggtgaacga atgaggaaac ttcaacgtac gacaatcccg
    15121 cttctgtaag tagttgaatc cattttactt tatcttttgt gccaacaatc tttttttcat
    15181 tctgtaagcc atcacgtggc ccgacttctt taatgacagc aaaattaggt agtttcaatt
    15241 cgcttccccc tatatctccc tattcaattt ctagtaatac atctccttca tttacaaaat
    15301 cgccttcttg tacgttaatt ttcataacag ttccggcttc ttctgaaacg attggaattt
    15361 ccattttcat agattccaaa atgacgacat cctgctcttc ctctactgta tctcctactc
    15421 ctacaactat cttccaaaca tttcctgcca tcgatgcata tactttcgtc atcatttttt
    15481 cccccttaat attcataaat cttatttttt aacaagttgt ttcgttacga aacccgttgt
    15541 ataaatacca cttttgaaca catcgtctcc gagcacttgc agtagcatcg gtgtatttgt
    15601 tttaatacct tcaattttta actcttctag agcaattttt aattttgaaa tcgcttcttc
    15661 acgagtttca ccatgtgcga ttactttcgc aatcattgga tcatagaaag gtgtaatcgt
    15721 tacttgattc tccaaaaagt gatcaatacg tatatttgtc ggtaacgtta aatctgtaat
    15781 tttcccaggt gatgggaaga atgttttcgg atcttctgca taaatacgag cctcaatggc
    15841 atgaccacta cgttttacat catcctgtgt aaatgatagc ttctcaccat atgcgataag
    15901 taattgttgt tcaactaagt ctaacccagt aatttcttct gtaactggat gttctacttg
    15961 taatctcgta ttcatttcta agaaataaaa gttcttttga tcatctacaa gaaactcaac
    16021 tgtacctgca tttgtataac caagtgcttt agcagcttgt acagcaactt ctcccatagc
    16081 ctttcgtgta ccctcatcta aaaatggtga aggtgcttct tcaattactt tttgatttcg
    16141 gcgctgcact gaacattcgc gttcccataa atacactgta ttaccatgtg tatctgctaa
    16201 aagctgaatt tcaatatgat gtgcatctgc tatatagcgt tctaagtaca tttctccgtt
    16261 accaaagaaa ttttgcgctc ttgttttatt actttcaaat gctttggtga gcgtttgctc
    16321 agtttccatc aactgcattc caatgcctcc gccgcccgcg gatgccttaa gcattaatgg
    16381 ataaccaatt tgtttcgcaa tttcaattgc ttcttcagca gtttcaatat ttgtagtaat
    16441 acctggaact actggcacat ctgctgcttg catcgctata cgtgactcaa ttttacttcc
    16501 catcttagta atgatttctt ctgaaggacc gataaatacg attccttctt ctttacagcg
    16561 aatcggaaaa gatggattct ctgataataa tccgtacccc ggatggattg cttcagcatt
    16621 tgtcttctta gctatttcaa taattttttc aaggtttaaa tagctttctt ggacacgtgg
    16681 accgcctact aagtaagctt catttgccaa ttttacatga agggcatttt catcagcctc
    16741 agaataaata gcaacggtac gaatgccaag tttttgacaa gttttcataa tgcgaactgc
    16801 gatttccccg cgattagcaa ttaatatttt ttgaaacata gtgactcctc ctttttatct
    16861 acatcctaaa tgtcttgcaa ttacgagacg ttgaatttca gaagttcctt caccaatttc
    16921 taaaagtttt gcatcacgaa tatatcgttc aacttcatat tcgcgcatat agccatatcc
    16981 accatggatt tgtactgcat gatttgctat acgacttgca gcttcagacg caaacaactt
    17041 tgccatagcc gcttctttac cgaaaggttt atcgttatct tttaaccaag ctgctttatg
    17101 tactaaatta cgcgctaatt ctacttcagt cgccatatca gccaatttaa attgaatcgc
    17161 ttggaaatta gaaatcggtt ttccaaattg ttgacgttct ttcgcatatt gcaatgcacg
    17221 ttcaaatgca gattgtgcaa tacctactgc taatgctgca attgaaatac gtcctccatc
    17281 aagtgtatat aagaattgtt taaatccttt atttacatca ccaagaatat tttctttcgg
    17341 tacacgtaca ccatcaagta cgatttcaca agtattagaa gcacgaacac ccatcttatc
    17401 gtaagggctt gaaatcgtta atccttcact agtagtcggt acgataaatg cagaaatacg
    17461 ttttttacca ttgtcttcaa aaccgttgat agcggttaca ataattgtat ttgcatactc
    17521 tgcgtttgta atccagcact tttcaccact aataacatat tcatcgccat ctaaaattgc
    17581 tttcgtttgt gtgccccctg catcagatcc agcatttggc tccgttaatc cgaaagcacc
    17641 taacgtttta cctgacgcca ttggaactaa aaatttctgt ttttgttctt ctgtaccgaa
    17701 ataataaatt ggagaagcac ctaatgaaat tgttgcagca tagcttaaac ctgttccacc
    17761 acaagcacga ccaatctctt caacagctaa cgcgtacgat aacgtatcgc cacctgaacc
    17821 tccatactct tccgggaatg ggatacctaa taatcctagt tcgcccattt tttgaaatgt
    17881 ttcatatgga aattccgcag ttttgtcata atatacagct ttcggtgcga tttccttttc
    17941 agcaaaatca cgtaccattt ctttaatcat ttgtttttcg cgagttagag taaattccat
    18001 tccgctacac accccttatc gaatattgag tttcgacagc gtgcgagttt ctactacaaa
    18061 cattacttct taaaagacac gaatattagt tagacaattg ctataattct gtcataactt
    18121 aattttaaaa cagattctgt accaatgcac aaaaaaattc ctacattgtt ctacaacaac
    18181 ataggaggtt ttgtgtcgaa ttatgtaatt tattgtttaa taatctctac cttttcccga
    18241 atcagaaatt tctactaacc cttcagggta tggttcgaaa tatgtttgtc ttaataaata
    18301 cttttcatca aatcgaatgg cccatgtttt taaaatgaca agtaaactac taagtgggat
    18361 tttcttttca gaatacttct gtaacagctc taaaaaatga tctttttctt gtttttttag
    18421 ctttgtttta aaatatccga aaatgtgctc acatacattt acattcgatg tatagcgagg
    18481 cgcgcgaata aataattcat ataaagtctt ctcatagtta tcaaatacga cttcaattgt
    18541 ttcatttttt tgatttgcaa taatacgccc taattctttt tgtttcacct gattatatgc
    18601 cataaataaa tacttataat ctgattgaaa cgctacgagt tcttttatgt ttttagtatg
    18661 tttaatcatt ttgtaatgcg cgattgtaaa caatcttgta aagaaatgct ctctaataat
    18721 aaaattcgac aatctacctt cttcttcaat tggaagatgc gaaaattttt ttattactgc
    18781 tccaccaaat aatccagttc cttttccttt tactggccct ttttcaaaac cagaatagat
    18841 tttcacatca cgagttccgc aacttggcga acgattcttc aaaataaaac cgtcaacttc
    18901 aggtaatgtt tgtaaaaatg catttgaaaa ttcattcatt ttttcagtta catcttctcg
    18961 tattgacggt tgtacaagcc tattcgcacc atttttttct acaatacgta tcgtttcacg
    19021 aggagtccct aaaccaattt ctacttcagg acatacaggt ataaatgtaa caaatggctg
    19081 caagtttcga attgttaaat ctggaaccat ctctccatta taacgacagg catcaaattc
    19141 taaacattta cttacaacaa ttatcggttt agcaaattgt cgcatcacat tacctccgtg
    19201 gcgttagtcc atacaatata aattgaatcg tattttcaat ttccacttca tcgtcccatt
    19261 tctcttccgg caataataaa aacctcgtta agagcaaccc taatacagct gataaagtaa
    19321 gacgtaatac ggaagatggt ggaagttcaa taatttcccc ttcttcttga aactttgcaa
    19381 tcagcttttt aaaatgtaca agcagttctg tttctattaa ttgttgtatt tcacttttta
    19441 gttccggctg aaatggtact tcttgaatta atatttttat cattggaaag tgctttttag
    19501 caaattcaaa tctattttga attattactc ttaaaagcac ttcatacgat tcatactctg
    19561 ttttaaatat ttcttttgca aaggcttgta cgaaaaatgg tgcagcaaac tttgttaagg
    19621 tcggcatcac gactgcaaac aataaatctt ttttcgtttt atagtagcgg aagattgttc
    19681 cttccgctac accagctcgc tttgcaattt cactcgttga agttgaggcg tacccttttt
    19741 ctccaaacat atcaacagct gcctctaata tacgcatttg acgttcatta cgtttatcag
    19801 cattcgttgc ggcaactaat tcttccagcc aatccttctt catttattgt gctccttttt
    19861 atcatcatta tattttgcga tgtttcttta atgcaaatac atttcctact gcaaataata
    19921 gtgaaaaaag tagtaataca gtaagatcta atgcaatctc tgtaaaccct tgattccgaa
    19981 tcattacttg tctcatagcg tcagcaccat atgtgagtgg aaataattta cctaacattt
    20041 gtaaccatgt attcatggat tccattggaa acaacccaga aaagaagact tgtggcacga
    20101 taacaagcgg tataaattga atcatttgaa attcattatt tgcgtatgcc gataaaaatg
    20161 tgcctaatgt tagtgcagtt aaagaaagca tacatgttat aagtagcgtt agccatattg
    20221 agccagctac atataaatct aaaatataaa ctgaaaaact tacaattata atagattgta
    20281 taagtgcaaa gattccaaaa ccaataatat atcctaaaac tatttcccat cttctcactg
    20341 gtgtggacaa taacctctct aatgtaccac ttaaacgttc tcttacaaaa gatactccgg
    20401 acaatataaa tacaaagaaa aatgtaaaga aaccaattaa tacgggacca agcccatcga
    20461 acatcgtaat gtctttagag ccatgtaaat aatccacttc aggcttcatc attgatacat
    20521 tattcttctc tgtactcttt tgcaatactt gaagtactgc acggtttttt gatgaatcac
    20581 tgccttctaa tagaagattc atttttccat tttctaaatg aattactgca tctacctttt
    20641 gcttttctaa ttccgaaatt gctttgtctt tactatattc ataaattgat gcttcttgat
    20701 ttttcattgc ttttactata ggagcaggta catcgactac agcaatatgc ggtatatagt
    20761 ctttttgtgt aaatattagc gataataacc aaagtaataa cattggtgcc ccaaacatca
    20821 ttgctaaaga acgcttatct cgaaaaaatt gacgaatgat acggatgact acaccattaa
    20881 ctctcatgat tcaatcactc cttctaacat aaagacatct tcaattcgtc cagaagatgt
    20941 ttgttttttc aattcctccg gtgtgccaat cgcaactaaa ttcccttctc taattagccc
    21001 tagacgttcg caaaactcag cttcatccat aatgtgcgtt gttacaataa tagttgttcc
    21061 tttcttttta aggtcataaa acttctccca aatcgatttt cgaagtagag gatctatccc
    21121 aactgttggc tcatctaaaa ttaatatttc tggttcatga aggagtgcta tcgccaatga
    21181 taaacgtttt ttcattccac ctgaaaaatg ctgtacttgc tttttcgtat gctctgataa
    21241 ttgcaaaagt tcaaaaactt ctacgattct ctctttctta cgcttacctt ttaacccata
    21301 catcgttgca ataaaatctg cattttcata tgccgatagt tcttcgtata atgcatcagc
    21361 ctgagccata taaccaattc ttttcatttc atttagatta ggcatgtttg tattaaaaac
    21421 aattacatcc cctgtagttg actcattaat acctgcaatc attttaatga gtgttgtttt
    21481 ccctgatccg gaaggtccaa ccaagccaaa aatttctgct ttttctactt gcagcgaaag
    21541 gttatgcaaa acttcttttt ccccaaattt ttttgataca tctcgtaaaa taattgaagg
    21601 ttgctgcact aaaaatcccc cttttcttta aaatgagtga gtactcactt ttattttact
    21661 ctcgaattat tatatgtcaa acttttcaaa catatatttt ttctgttatt tactaaatca
    21721 atgaaacaga gtcgacatta gaatatcttt tcttaaagtc gactctgttt cattgtaaat
    21781 tatttgattt ttgttatgtt tttaaattta aataccttct aattctagca acatctaatg
    21841 aatattcgat aactatttgc tgtattggta atataaccgt ttccggatat aaatgtgcat
    21901 attgtaacgt ttctgcatac ttttccaacc gtttttctaa atactttaca atttgctcag
    21961 gatgacttac taataaagac gtactataat aatgaatttg ctcctcaatc gccgtatatt
    22021 cttcaatttc aaattcttta tgcatttgta caccccttta tatttttaat attgcttaat
    22081 aataactatt ttaactcgac taatttttaa gttttttgat tatttacact ataacaaact
    22141 caataggtca aattttgtta ctttatgtaa cgttgaaaaa ttttaacaaa attgtaatgg
    22201 aaacttgtac tcaagaaaaa ctacctttaa attattctcc tgaacaaaaa agccgtacag
    22261 attaatttaa ctgcacgact acaatctcag gtctattaaa aactctttgc ggaatgatac
    22321 tattgcctaa tcctctacta actatcatag acgtattttg ttgttcatat aaacccgctg
    22381 tatatttggg cagtattcct tgattaggag caactaatcc cccgataaaa ggtaaccgaa
    22441 cttgcccccc atgtgcatga cccgataaca ctaaatctac ttgctcatca gcatatgctt
    22501 ctaaaaattc aggcctatgg gataataata cattatacct atctggcagc gtttcaattt
    22561 ttgcttttac aattgcatct tttacaatac ttccttcatc aatatctcca gtattaaatt
    22621 ccggatcatc aattcctaac aagtttattt cgtgtcctcc cttttgtatt attacatgtt
    22681 catttcttaa aacagtgaca tgctgtttct ttaatttttt ttctaaactg ttatatttcc
    22741 ctgaccattt ttcatgattt cctgtcacaa aatataccgg atattccttc acaagttctc
    22801 gtattacttg catactcatt tctgcatcgt acgatttact gtctattaaa tcacccgtaa
    22861 tagcaataat atctggattt atgcttttta ctttttgaat taaaacgtct tgattatcac
    22921 caaatttttt attatgtaaa tctgaaattt gtagtatttt atatccttta aaagaagagg
    22981 gaattttact agaggttatt ttaacctcag ttatacttat taaattgttt tgtaaatata
    23041 aaaagatact aatgcctact aatataccaa taattaatat gattctttta atcttcttgt
    23101 tcatacttcc tcctaaaatc ttaatcagta ctacagttca caataaatat tacgtgccct
    23161 tcgcattcag aataactgaa attttttaat tgatttgtag tatttgttat agttttatac
    23221 gccacttata aaatttttca atcgcatgcg tgtatgatgt catgctcatt tctcagtaat
    23281 tttatagcag atcactggaa tctcttcata atattaacat ttatcttact tagtttgata
    23341 actatatcat gataattcct atagtttttt ataaaaatat tgtgtacttt tctcgaagta
    23401 tatacgacat ttgattacaa atatattatt accactacga ttttaatttg tttaaaacgt
    23461 acaaagagag aattgaaaca ctaaattgcc ttatgaaaag gtattactgt attatttatt
    23521 agaaaattga aaaaacatgt gtagatagct atcattgtaa gtgcatatat aattaacttt
    23581 aattttctga cataatttca cataattctt aaactatttt tttgcgtgca ttatgaaata
    23641 aaatattgcc ccatgtcagt ctttaaaaaa ttatatatca taactttaag ggaggaagaa
    23701 aactatgaag atgaaaagaa aaatcatgat gacgacagca cttgcagcta cattggctac
    23761 aggtgcacta ccaagtacat cggtgtttgc tgctgaaaaa gaggctccta tccaacaaga
    23821 agagacacag atgagtattc aaccatttgc acaaaataat ttggaaacag cagttaaagc
    23881 tgccttaaat ggtccagaag ttaaaaaaat taaagtattt gagcatgaat ttaatgtaaa
    23941 accaattgaa gtagtaaatt taggtggcgg taaaacatat gttaagggac aaatttctca
    24001 tcatttaagt tttcgtccag atgatcaatt ttattatgag tttacagtgc aagatggaaa
    24061 ggtaatagat aagcctgtat ttaatattga tagaggtggt tggacaccat ttactgctcc
    24121 acttttatca attcttgctg cgtataatgg gattccagta aatccaaatg atttaaatgc
    24181 acttggtcaa caaattggga aagttataga tggaagctgg gaacatgcag cccaatctat
    24241 cgcaactgta gttagtttaa gttttaatga atagaatttt taaattttta ttagcattgt
    24301 agagatccac ttttcctaag tagccttgtt ataagaaatt ctgaaacagc tataaataga
    24361 tttttaccac tcagtcacat tatcttgatt tgttaaccac cttatcattc attatatgtc
    24421 acaaaataga agtctttttt aagacttctg ttttgtttgt atacagtaca gcggaaagtt
    24481 tgttttttac ctatctatgc ttcaattctt taagaatccg tttgactatt agatacaatt
    24541 tattacaaca aactattaaa atctcaaata acttcctacc ctattttgat tttttcaaac
    24601 acaaaaattc attactttaa gaatgaaaac aatagatgta gtaaaaaatc atcttgtttt
    24661 attatatcta ttgtttaaaa gtcaggagag ataaaatgaa caaaataaaa atgaggaatt
    24721 tttttaaaat tagtatcctt acttgtttca cactagcaag tttaagtaca ccatctacta
    24781 tttttgctga tagtcatcca ggttattcct atgaatccaa tataggctat caaaacccag
    24841 catggatgtc gaaagtagca gattcaacaa aattgagtga aatatctatt ccagggactc
    24901 acggtacaat ggctttacat ggagcaagtt ttcttgatga aaatttgaca agaaatcaaa
    24961 ctatgagtct accacaacaa ttaaattccg gaattcgata tgtagatatg cgtgttaaac
    25021 gtgtaaaaga ttcttttgca atgtaccatg ggattgtaaa tcaaaaagca atgtttgaag
    25081 atgtattaaa agaggcaatt caatttttaa aagatcatcc tacagaaaca attttaatgc
    25141 gcttaaaaga agaaactact cctgaaagtg gctcactatc attcgaggaa atacttaata
    25201 aatacaaaga ccttaattct tcctattttt gggatccg
//
