LOCUS       NC_015600              26034 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Streptococcus pasteurianus ATCC 43144, complete sequence.
ACCESSION   NC_015600
VERSION     NC_015600.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pasteurianus ATCC 43144
  ORGANISM  Streptococcus pasteurianus ATCC 43144
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1
  AUTHORS   Lin,I.H., Liu,T.T., Teng,Y.T., Wu,H.L., Liu,Y.M., Wu,K.M.,
            Chang,C.H. and Hsu,M.T.
  TITLE     Sequencing and comparative genome analysis of two pathogenic
            Streptococcus gallolyticus subspecies: genome plasticity, adaptation
            and virulence
  JOURNAL   PLoS One 6 (5), e20519 (2011)
   PUBMED   21633709
REFERENCE   2  (bases 1 to 2100077)
  AUTHORS   Wu,K.M. and Liu,T.T.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-FEB-2011) Contact:Keh Ming Wu National Yang-Ming
            University, Genome Research Center; 155, Sec.2, Linong Street,
            Taipei, Taiwan 112, Republic of China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 1.1.03.24
            Genome Coverage                   :: 34X
            Sequencing Technology :: 454 GS 20; Illumina GA II; ABI 3730xl
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000270165.1-RS_2024_03_30
            Annotation Date                   :: 03/30/2024 01:05:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,115
            CDSs (total)                      :: 2,036
            Genes (coding)                    :: 1,937
            CDSs (with protein)               :: 1,937
            Genes (RNA)                       :: 79
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 99
            CDSs (without protein)            :: 99
            Pseudo Genes (ambiguous residues) :: 0 of 99
            Pseudo Genes (frameshifted)       :: 56 of 99
            Pseudo Genes (incomplete)         :: 56 of 99
            Pseudo Genes (internal stop)      :: 28 of 99
            Pseudo Genes (multiple problems)  :: 32 of 99
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:43:35
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1131828
            Orig. end                         :: 1157862
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP012054.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26034
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26034
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26034
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16034](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16034)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(667..825)
                     /locus_tag="SGPB_RS11570"
                     /old_locus_tag="SGPB_1088"
     CDS             complement(667..825)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012640.4"
                     /locus_tag="SGPB_RS11570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1088"
                     /product="chorismate-binding protein"
                     /protein_id="WP_253066431.1"
                     /transl_table=11
                     /translation="MTIRPMKATIARGINDAQDFRNKHWLANDSKNRSENMMIVNLLRN
                     DTGRILG"
     misc_feature    835..848
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.52"
                     /tool="antismash"
     misc_feature    complement(836..849)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.95"
                     /tool="antismash"
     gene            complement(897..1100)
                     /locus_tag="SGPB_RS11575"
                     /old_locus_tag="SGPB_1089"
     CDS             complement(897..1100)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012640.4"
                     /locus_tag="SGPB_RS11575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1089"
                     /product="chorismate-binding protein"
                     /protein_id="WP_003065073.1"
                     /transl_table=11
                     /translation="MNITMPQVWESKTDKDEYEKAISEIRQQIRQGNIYQVNYTVQLHN
                     RINSNLFELYNRIVIEQGAKYN"
     gene            complement(1124..1318)
                     /locus_tag="SGPB_RS11415"
                     /old_locus_tag="SGPB_1090"
     CDS             complement(1124..1318)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SGPB_RS11415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SGPB_1090"
                     /product="hypothetical protein"
                     /protein_id="WP_003065075.1"
                     /transl_table=11
                     /translation="MHKKTVVDFKELGHQLIFENPVRILATKLIGDVDAILKKVVHKDI
                     VLLVMSVMRQEKYLKTIFL"
     gene            complement(1334..2221)
                     /gene="rarD"
                     /locus_tag="SGPB_RS05690"
                     /old_locus_tag="SGPB_1091"
     CDS             complement(1334..2221)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /gene="rarD"
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003065078.1"
                     /locus_tag="SGPB_RS05690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1091"
                     /product="EamA family transporter RarD"
                     /protein_id="WP_003065078.1"
                     /transl_table=11
                     /translation="MKKTNLGILFGLITYILWGFLSLYWKLLSGVNSYNTFSYRIIFTV
                     LTMLVYMVLSKNKERYRGEIRQLISHKQELAMAVLASFLIALNWLTYIFAVSHQQATQA
                     SFGYYIMPLVSILLALVFLHERLSPWMTAAIIIAGIGVGILAINTGQPPLVSILLAVTF
                     ALYGLVKKNVKLSSDVAMLVESSVVAPFVLIYLLFFSKETLLDYSLLENVLLLASGIVT
                     AIPLLLFAEAVKRAPLNIIGFIQYINPTIQLAIAVFVFHEKVGNGEVSGFIFIWIAIAI
                     FILGQLMSLRKKSR"
     gene            complement(2208..3074)
                     /gene="thrB"
                     /locus_tag="SGPB_RS05695"
                     /old_locus_tag="SGPB_1092"
     CDS             complement(2208..3074)
                     /EC_number="2.7.1.39"
                     /GO_function="GO:0004413 - homoserine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009088 - threonine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294652.1"
                     /locus_tag="SGPB_RS05695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1092"
                     /product="homoserine kinase"
                     /protein_id="WP_003065082.1"
                     /transl_table=11
                     /translation="MKITVPATSANVGPGFDSVGVAVSKYLTIEILELSERWEVLHDLG
                     DVPSDETNLLITTALQVKADLQPHRIKMVSDIPLARGLGSSSSVIVAGIELANQLAHLQ
                     LSADEKLVIATKIEGHPDNVAPAIFGNLVISSYVNEKVNSAVVAFPEASFVAFIPNYEL
                     KTSDSRNVLPNEFSYKEAVAASSIANVAIAALLTGDLEKAGKAIEADLFHERFRQKLVK
                     EFAPIKEVAHKVGAYATYLSGAGPTIMVLAPKAKEAELVERLAALALDGEVVALHVDTK
                     GVFVEKD"
     gene            complement(3132..4418)
                     /locus_tag="SGPB_RS05700"
                     /old_locus_tag="SGPB_1093"
     CDS             complement(3132..4418)
                     /EC_number="1.1.1.3"
                     /GO_function="GO:0004412 - homoserine dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019313981.1"
                     /locus_tag="SGPB_RS05700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1093"
                     /product="homoserine dehydrogenase"
                     /protein_id="WP_013851896.1"
                     /transl_table=11
                     /translation="MSIKIALLGFGTVASGVPFLLKENPSKITEAAHDRIEITKVLVKD
                     DDERNRLLAAGNDYNFVTNIDDILSDDSIDIVIELMGRIEPARTFITKALEAGKNVVSA
                     NKDLIATHGKELIELAKDKGVAFYYEAAVAGGIPILRTLANSLTSDKVTRILGVLNGTS
                     NFMMTKMVDEGWTYEDALKTAQDLGYAESDPTNDVEGIDAAYKAVILSQFGFGMTIDFD
                     DVAHKGITTITPDDVAVAQELGYVIKLVGDVREVESGISAEVSPTFLPKAHPLASVNDV
                     MNAVFVESIGIGESMYYGPGAGQKPTATSVTADIIRICRRIKDGNVGKPFNEFVRETKL
                     ANPADVKSHYYFAINTPDKKGQLLRLAEIFNSEDISFEQVLQQKANGTRARVVIITHSM
                     SKTQLADVTAKLEAVEDFQVVNTLKVLGE"
     misc_feature    4412..4427
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.54"
                     /tool="antismash"
     misc_feature    complement(4443..4458)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.44"
                     /tool="antismash"
     misc_feature    complement(4721..4735)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.54"
                     /tool="antismash"
     gene            4840..5790
                     /locus_tag="SGPB_RS05705"
                     /old_locus_tag="SGPB_1094"
     CDS             4840..5790
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003065091.1"
                     /locus_tag="SGPB_RS05705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1094"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_003065091.1"
                     /transl_table=11
                     /translation="MEKRRQHQKHSNKPLAIINIILLIACIVASVFLFIALKENNFIFS
                     TTKTEQVSSSSASHTNTTTTSSASTVTSDSSSANTNENEVNWVKQDSNVSVPILMYHAI
                     HVMAAEEASNANLIVDPTTFESHIQRLSEEGYYFLTPEEAYKVLTENVLPNDNSKIVWL
                     TFDDSLWDFYDNAYPILQKYGAKATNNVITSTVGNSGNLSLDEMLEMKANGMSFQDHTV
                     THPDLSASDNATQTSEMEDSKNYLDTNLNQDTIAIAYPAGRYSDTTLQIAANLNYKLGV
                     TTNEGIASASDGLLSLDRIRILPTTTADSLIASIS"
     misc_feature    6194..6208
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: medium, score: 22.82"
                     /tool="antismash"
     gene            6335..6499
                     /locus_tag="SGPB_RS11420"
                     /old_locus_tag="SGPB_1096"
     CDS             6335..6499
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="SGPB_RS11420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1096"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_003065096.1"
                     /transl_table=11
                     /translation="MSDVSRRTFYRHFANKNELLNHYFEQIINRYLTERKYFTETDNFQ
                     DMLAKSMNF"
     gene            complement(6839..8038)
                     /locus_tag="SGPB_RS05715"
                     /old_locus_tag="SGPB_1097"
     CDS             complement(6839..8038)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636594.1"
                     /locus_tag="SGPB_RS05715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1097"
                     /product="site-specific integrase"
                     /protein_id="WP_013851897.1"
                     /transl_table=11
                     /translation="MTTKSSKKYKGVYCDNKGKIFYQIDLGIDPVTGKRVQKKARKNQY
                     GKTFETMKEAYDELVRIKYEFANKVSLENYNMTFENYMNTIYLRAYKQKVQSVTYKTAL
                     PHHKLFIHYFGSKPLKAITPRDCEAFRLHIIENYSENYAKNLWSRFKACMGYAERLGYI
                     SDMPCKALDNPRGKHPETPFWTYAEFQTFIKSFDLHDYEELQRFTAIWLYYMTGVRVSE
                     GLSLCWEDIDFDKKFLKVHTTLEKDENGNWYRKDQTKTPAGERLIELDDITIEVLQVWR
                     KNQFANQDTDFIISRFGDPFCKSTICRIIKRKAQQVGVPVITGKGLRHSHASYLINVLK
                     KDILYVARRMGHADKSTMNTYSHWFNALDKTVSEEITQNIKSAGLDSILCQNSCQTSNL
                     "
     gene            complement(8061..8288)
                     /locus_tag="SGPB_RS05720"
                     /old_locus_tag="SGPB_1098"
     CDS             complement(8061..8288)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106749.1"
                     /locus_tag="SGPB_RS05720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1098"
                     /product="DUF3173 family protein"
                     /protein_id="WP_001258320.1"
                     /transl_table=11
                     /translation="MRTATYKDLMNLGFPEHTSRDIIREAKRIAVKKFEEARKVDHNAV
                     QLSKSPFDNRRLGIAPAEIVEQLIGIPLSK"
     misc_feature    complement(8426..8436)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(8613..9017)
                     /locus_tag="SGPB_RS05725"
                     /old_locus_tag="SGPB_1099"
     CDS             complement(8613..9017)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368528.1"
                     /locus_tag="SGPB_RS05725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1099"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_013851898.1"
                     /transl_table=11
                     /translation="MKYYIHVRGSKIPVTEAVYKSYWQLVNHEKYLNRKDRKFGMLPFT
                     SFEVDGLPLENILPDTTVDVESFVETKLLIEQLNEALLTLSDKEFEIIDALYFRGHTIR
                     EVAIEHEMSATSLFRMRNTILDNLRKFFER"
     gene            complement(9283..9999)
                     /locus_tag="SGPB_RS05730"
                     /old_locus_tag="SGPB_1100"
     CDS             complement(9283..9999)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226539.1"
                     /locus_tag="SGPB_RS05730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1100"
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_001226539.1"
                     /transl_table=11
                     /translation="MRKILFSLVVLIGICTLVACRLVDNKTIEFHDQSFNQFTYKGNDY
                     TIMNQIVDENDLGTVKESFFKTLVIDRNSQKVVTKSNSDTVSLAYSGLYNFSDGLAISI
                     NDSYYKVSLSSDVQSNNEMLSLEEFNNNSAGGELAIDPSDCRIVKFNNKKFRISSDIVS
                     DDKLKEFLGVIADSKTFILNTGQEISKSELNKIDYSGSNSNEKREVWDYGEVYLLAEEG
                     TIAVEINNEFRIARIE"
     gene            complement(10001..11278)
                     /locus_tag="SGPB_RS05735"
                     /old_locus_tag="SGPB_1101"
     CDS             complement(10001..11278)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344171.1"
                     /locus_tag="SGPB_RS05735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1101"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_013851899.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-57, bitscore:
                     191.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDENKVIIDLSEKVFAKFDEQLKRYAEQPNYDLLTLSSGLPGLIL
                     LSSELTSLTSERKYSVRTGKYVNFLVKQMRNYGVLSDSLFSGVSGIGISILHLVEEHPE
                     YHNLLISFNEYIKYYTLSKIENIDIKKISPTDYDIIEGVSGILVYLLSQEQDENDYIIN
                     RIINFLSEFSLKNSTLTGFYVESKNQMSKTESKLYPLGCLNFGLAHGLAGVGIMLSYSK
                     LKGYSNEKSIAAIKKIIMLYEKHELKNYMWKEGLSDIELKKTEKSNLQYEFIRDAWCYG
                     SPGISLLYLYSSLALEDKKLKSKACNILKASIRRSNGLEQSILCHGFSGAIEICLFFKK
                     IYKTTDFDDCIKSLKEKLISDFREDMTYGFNTTAEFENIKTKDNLGYLDGIIGILLTMI
                     ELNNLKVTTNWQRALLLFDDVIKEVK"
     gene            complement(11271..11921)
                     /locus_tag="SGPB_RS11425"
                     /old_locus_tag="SGPB_1102"
     CDS             complement(11271..11921)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="SGPB_RS11425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1102"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_231844739.1"
                     /transl_table=11
                     /translation="MGKNGSGKSTLVKLLSGLYQPSEGQIYYNNESSDVLDLSYYQNNV
                     SVLFQDFVKFELSVRENIGLSDVNSISDSKIKKHIDNLKLNFLTAENNFNLNQRLGTWF
                     NDSRQISGGQWQKVALARTFFKNASIYILDEPSSALDPVSEKEIFDEFVTRSKDKIALF
                     VSHNLMAASRADRIIVMQDGRIIDEGKHDDLISKSKYYRELYYSEKYEEESDG"
     gene            complement(11966..13066)
                     /locus_tag="SGPB_RS11430"
                     /old_locus_tag="SGPB_1103"
     CDS             complement(11966..13066)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="SGPB_RS11430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="SGPB_1103"
                     /product="hypothetical protein"
                     /protein_id="WP_230321715.1"
                     /transl_table=11
                     /translation="MDKFTLKNFFQTILTIPKTIRLIFRIERKYASYLIILNILQSIIP
                     LASLFIYQELINAVLKKGSNIFSVLIVYILMQMMLSILSQLNSYISEKFNMNLSYNLNL
                     KLLKKTSSLNLIDFEQADTYNLIENIVQDSTYKPFQLFNAIIGVITGFLSLLTSIIYVS
                     TWNVAVSTFLLIIPVISLVIFMRVGQLEFLIQWERANSEREVWYINYLLTHDFSFKEIK
                     LNGISQYFIDKYGTLKRNFMNQDLNISKKKVLFRGSLDILLNFINGIAIFMMIQSIRSG
                     KLLVGNFVSLIQAITRVNTYSQSMIQNTYIIYNTSLFMEQLFKFFDMEISNISIQNSRI
                     SRIEKRIDKIKVNNLSFIYPGSVKKL"
     gene            complement(13059..16034)
                     /locus_tag="SGPB_RS05745"
                     /old_locus_tag="SGPB_1104"
     CDS             complement(13059..16034)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400478.1"
                     /locus_tag="SGPB_RS05745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1104"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_013851900.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-88, bitscore:
                     293.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.3e-07,
                     bitscore: 27.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-20, bitscore:
                     70.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHKYTTNNFLVRNAIIGIHELLECDYNSFLETIRENKIFQEQLF
                     VASRSLYESLQKYYSGDSMKRKKINQLSESVYKYYKRSKERSTPFGLFSETSIGSFSST
                     EKLNLNGKTLKKVLLDSEWLIRLVFKIEKEYSRELAYKINPANYQFGDRVVQLFSINDT
                     KIEEVNIKFTKVYQLIDELCCDKYIYFNCIIEKLVESYGEEYRDIATSYIMSLIDSHFL
                     ISNINSELIMNFKFEEFISKVKEIDKQNLYYFKLIVISNLIVEYSELEIGDGIEKLQEI
                     YKLMSSLVETPNFLQIDFYNDGQIQLGNENKTQIVEFAEFLVSNSDHVKRTYLDDYKEK
                     FLDKYGVNREVQLMELFDSNLGIGSPYGYQHPKNDFWESSPSTVYFSEKEELEYLNNFE
                     KALETGGNIQLYNEEDFFNQDKDKINVGFELFFYVNKVDGKSVLSLTNTGCSKNLGASS
                     GRFSILSDKLEHYHQTITQIVENNNHVSGYNSCEITFLPENLRHANVMRTTNVREKVLS
                     LFTNMDKRSQILSEIYIGIDSKNSFYARNFKTKELLKFYSTNMYNQMMFSNELRFLCEI
                     AQEDHFGIFPWEMVYQKFSHIPRIVFKDIIVAPERWRLSGRMLSKDIHQIILENNLPTK
                     FYVDNSDNRILINRNNPLDNQLFEDIVRKSSNKNEELCLSECIFDSHLVEKESTTHISD
                     IVVPVFAKDEIKEPRYIKEILPEVIPTNVRQKIPFDEWLYFKLYMSADRQEEFLSDIMP
                     QILKLVNLDDGMSFYIRYTDPKFHIRLRIRTQNLYKSFEKIQEIFQLCIQNKLISNIDI
                     STYDREIERYGGLERIPLVEEIFCLDTEIVINSLSLIRQKRLDLTLDDLAIIFNYFYLK
                     SFFKDNNKEIIQFLEFACPEHLDSQNRDKNRNTALIDLYLIKGYLINLLPELSKLCQRL
                     KKLSDSCIQLSDDYTYIIYDSIIHVHNNRLFGIKRENETKIYAIIRGLIISEEFRNGHN
                     HG"
     aSDomain        complement(15357..15602)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_SGPB_RS05745_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="8.70E-09"
                     /identifier="RREFam001.1"
                     /label="SGPB_RS05745"
                     /locus_tag="SGPB_RS05745"
                     /protein_end="226"
                     /protein_start="144"
                     /score="27.0"
                     /tool="antismash"
                     /translation="PANYQFGDRVVQLFSINDTKIEEVNIKFTKVYQLIDELCCDKYIY
                     FNCIIEKLVESYGEEYRDIATSYIMSLIDSHFLISNI"
     gene            complement(16275..16442)
                     /locus_tag="SGPB_RS10680"
                     /old_locus_tag="SGPB_1105"
     CDS             complement(16275..16442)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058290.1"
                     /locus_tag="SGPB_RS10680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1105"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_001058290.1"
                     /sec_met_domain="TIGR03731 (E-value: 5.7e-22, bitscore:
                     74.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 4.5e-06, bitscore:
                     22.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNEDFNLDLVTISKENNSGASPRVTSKSLCTPGCKTGILMTCAI
                     KTATCGCHFG"
     CDS_motif       complement(16371..16442)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNEDFNLDLVTISKENNSGASPR"
                     /locus_tag="SGPB_RS10680_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16275..16370)
                     /prepeptide="core"
                     /locus_tag="SGPB_RS10680_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="27.40"
                     /molecular_weight="2989.6"
                     /monoisotopic_mass="2987.5"
                     /core_sequence="VTSKSLCTPGCKTGILMTCAIKTATCGCHFG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNEDFNLDLVTISKENNSGASPR"
                     /leader_location="[16370:16442](-)"
                     /alternative_weights="3007.6"
                     /alternative_weights="3025.7"
                     /alternative_weights="3043.7"
     gene            complement(16790..17476)
                     /locus_tag="SGPB_RS05750"
                     /old_locus_tag="SGPB_1106"
     CDS             complement(16790..17476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001033677.1"
                     /locus_tag="SGPB_RS05750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1106"
                     /product="hypothetical protein"
                     /protein_id="WP_013851901.1"
                     /transl_table=11
                     /translation="MNKILKSELLKLKGSLTLNLILILSIIQLFTIPLYLQFTNNSVVI
                     ENIIFLPMLGYCILASIFSIFLHEQEEKANFFQNIKSEKNSRMIWGIKLISTDLLMVLL
                     GVPVWIVVGVEFNRLSYFVYVGVITWLLLVLLNHLHMLFSLIMGKGGNLVISFIECLFI
                     IFATNKVFLNIFWLPIVLPVNMILEIGKNEIFMILVYLIGFIILSYFCNLAVMNNVEIQ
                     KICKKR"
     gene            complement(17454..18191)
                     /locus_tag="SGPB_RS05755"
                     /old_locus_tag="SGPB_1107"
     CDS             complement(17454..18191)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851902.1"
                     /locus_tag="SGPB_RS05755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1107"
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_013851902.1"
                     /transl_table=11
                     /translation="MTNIFKSEWLKQKSSSDKKLLILIPLLAIFIAFILAGPLNLESFS
                     IYWWEGGFLFTLLGLLFLADYSAEENAGAFQNISLGRYTFTIYLAKILLKFKDVLISTF
                     IFMIIFYGISFLFSGVMSVDIGKDLICLLLIGVSSAWVLPLLYFLAKWINPYLLLATNS
                     LICLLVAPLIAQTSVWFIFPYTYHYKIAYALLHLKPSGDLEAALSGVEISTILISVSLS
                     ILVFVSFLSLLKWRITNEQNSKK"
     gene            complement(18184..18885)
                     /locus_tag="SGPB_RS05760"
                     /old_locus_tag="SGPB_1108"
     CDS             complement(18184..18885)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000452012.1"
                     /locus_tag="SGPB_RS05760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1108"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013851903.1"
                     /transl_table=11
                     /translation="MEVIIQNLRKSYKDKEVLKDVSFKIEEGTICGLLGVNGAGKSTIM
                     KILFGLERADSGEVIFNGKHKDIVEENRFDIGALIESPAIYLNLSAFDNLKTRALLHDI
                     PDERIYEVLQLVGLSDTGKKKAGHFSLGMKQRLGLGMAIITNPDLLILDEPTNGLDPDG
                     IKELLNLIRDLKKSGMTVLLSSHQLSEVSKIADQIVILNQGKIFYDDTNKNSNDLENLF
                     FRIVHGGDGND"
     gene            complement(19076..20419)
                     /locus_tag="SGPB_RS05765"
                     /old_locus_tag="SGPB_1109"
     CDS             complement(19076..20419)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977994.1"
                     /locus_tag="SGPB_RS05765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1109"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_043910208.1"
                     /transl_table=11
                     /translation="MMKRYSINKRILRTVLEIVIGTVANVIMLLVLSYVLIFTGQLNTY
                     GTDYHISISDSKSASSIKNQMDYSVFDYVLFDSDNGELVSGKYQKQDLQYYKEVFDTGS
                     SVSKGSILFTEYENSDFILVIRRPTMPEFVNRNFRHISYNLVSYLFFIVLELLLISISV
                     IRLLREFTKNFRLIEKISLNMGIPGMDIGHKETEILECNNILLTLYQKDEELTKLLEME
                     KKDKEDLSFQVAALAHDIKTPLTVLKGNIELLEMTNLDEKQLDFMSSMNHSVGIFEKYF
                     NSMVNYSRLLIEDKNYREDIELAEFLDELSLEYRDIMSSKKINFQIVNESHTRVIKGNR
                     LNLDRALINILSNATRFCSEEGKVVLTISESSNFISFEIWNNGLPFTEESLKDGGKLFY
                     TENKGRNDKHYGIGLSFAQKIAMRHQGQLILSNPQNGGAQVTLLIKKF"
     gene            complement(20397..21095)
                     /locus_tag="SGPB_RS05770"
                     /old_locus_tag="SGPB_1110"
     CDS             complement(20397..21095)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000276750.1"
                     /locus_tag="SGPB_RS05770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1110"
                     /product="response regulator transcription factor"
                     /protein_id="WP_013851905.1"
                     /transl_table=11
                     /translation="MYKILVVDDDFEIVKLMRTILEMKNYNVTTYQEVRLPIKISDFDG
                     FDLILLDVMMPNVDGLQICKQIRKSVSSPIIFVSAKDSEDDIVSGLNLGGDDYITKPFS
                     VNQLVAKVAAHLKREERYRNAESNESVIRELLPLTFYLQEKLVCVNGEAISLTKREYDI
                     LELLSSKTNKVYTREEIYECVYDDEADALFRSISEYIYQIRVKFVPYGINPIKTIRGMG
                     YKWNDEKIFN"
     gene            complement(21136..22509)
                     /locus_tag="SGPB_RS05775"
                     /old_locus_tag="SGPB_1111"
     CDS             complement(21136..22509)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000719507.1"
                     /locus_tag="SGPB_RS05775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1111"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_013851906.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.9e-37, bitscore:
                     125.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIGLLSNVFISLFIVILASGSVSSGVSANENKEISYNVLVSEN
                     KSIEDVEDVLQSQGIKVTDKIPEINFLTISTEKSEDTIKKENSNYIDDIVIDNTMTVKP
                     NITYLYGDKVYTNTNLDFWGNQWDMQKSISTGSKFQHKSSGKATIGVIDSGITYDNPDI
                     YSHIISVQNFTSDLETGIVDNQNVVDKIGHGTSVVGQISSSGEYLGIAPDMKIRMYRVF
                     DEGNAQDQWILKALIQAAKDDVDVINLSLGEYLLRDSTDEDDDTALINIYQRAINYAHN
                     QGSVVVASVGDEGMDLQNQDELKNYLGSLRGKDYSQVDGTVQDIPAELDNVVTVGSVDD
                     NDLVSSFSNQGNDDIDIYATGGGSQALSKVGYDKWVADKLYEKEWILVPTLEGKYTYAY
                     GTSISTPKVSAALGLIIEKYNLKDQPDEAIRILYDNCFLSNNGNNGQIRLLNITNFVQ"
     gene            complement(22614..24488)
                     /locus_tag="SGPB_RS05780"
                     /old_locus_tag="SGPB_1112"
     CDS             complement(22614..24488)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000261813.1"
                     /locus_tag="SGPB_RS05780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1112"
                     /product="SAG1250 family conjugative relaxase"
                     /protein_id="WP_013851907.1"
                     /transl_table=11
                     /translation="MVVTKHFAVHGNKYRKSLIKYILNPAKTDQLKLVSDFGMSNYLDF
                     PNYEEIVEMYQANLVNNDRLYDSRNDRQQIKQNKIHAHHLIQSFSPEDNLTPEEINRIG
                     YETIKELTGGNFRFIVTTHTDRSHVHNHILINSVDLNSHKKLKWDYAQERNLRMISDRL
                     SKEAGAKIITPNRYSHEKFVTYRKSNHKFELKQRLYFLMENSKDLDDFLSKAEALNVQI
                     DFSRKYARFLMTDMPMKRVIRGKQLDKRQPYTEEYFREHFAKRAIEQCLDFLLPRVRDL
                     SQLLEFARELNLAMSLKQKNVAFTLTKNSQSITVNNQKVSSKNLYDVQFFETYFEKRGE
                     VPDIDQSQLISDFEGYCEEQDKEKLAYEDLQEAYQAFKEKRDQAQEFEVVLADHQIDKL
                     VKDGLFIRMNYGVKKDGLVFIPNRHLDIKETESGKHYHAFIRETAQFFIYNKEASELNR
                     YMRGRELIRQLTNDSQTISKRKRPTIDTLKKKIEEINLLIELGTENKSYQDIKDEIIKD
                     IAQLDLTITEIQEHIDHLNKVAEVLLNLDNNDIENRRLAKYDYAKMNLTAAIKLEQVEK
                     EIEIYQIKLDKSIDDYEYLIRRLEKFVKILNEIDSSKDELKFEHSEKM"
     gene            complement(24475..24840)
                     /locus_tag="SGPB_RS05785"
                     /old_locus_tag="SGPB_1113"
     CDS             complement(24475..24840)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000263054.1"
                     /locus_tag="SGPB_RS05785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1113"
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_013851908.1"
                     /transl_table=11
                     /translation="MENRYRTNLKKVFLTDQELANLNNHISQSSCQNFSAYARKVLLNP
                     NMTFLTIDTSNYQDSVFELRRIGNNINQIAKTVNQTKLLTVEQRDNLKTGIGQLIAEVD
                     KDFYVKCQKLREFYGSH"
     gene            complement(24843..25205)
                     /locus_tag="SGPB_RS05790"
                     /old_locus_tag="SGPB_1114"
     CDS             complement(24843..25205)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851909.1"
                     /locus_tag="SGPB_RS05790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="SGPB_1114"
                     /product="SAG1252 family conjugative relaxosome accessory
                     protein"
                     /protein_id="WP_013851909.1"
                     /transl_table=11
                     /translation="MTESYRTIRKEINLTLEEFEQIQLLMRKENAEQFSPFVRQKLLDI
                     VNNKDDIRDWFILWQSQKTEQISRDILQVATLAERGHQVTSEHLRIILTCVQELMTEVE
                     KAVPLSSEFRDKYMGG"
     misc_feature    complement(25313..25327)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 19.31"
                     /tool="antismash"
ORIGIN
        1 acgctattac acacagaaaa atatggttag cattctccaa atctgtcttt gctaaatagc
       61 gtgcagttac ttctccttgt tgaataaaat acttcctatg cataccatct aatattccaa
      121 cttcaactat cagagtataa taaatcccat tgatttctaa aataatattc cctattgaag
      181 tttcttgcgg atagccatca ctagaaatga aaacttgttc cttatcagaa ttaggaatat
      241 gagggcgata acttatttta aaataggtaa aaggggaatc acacgcttct tctctttgaa
      301 ccaatttagc ctgtaaaaac gttgagggca aatctagtgt cttaagcaat tctgaaattt
      361 tatctaaaaa ttctgtttca gaaaaaggcc atccaaaaaa tcgagccgaa cttttttaaa
      421 cgctttgtat gctctttagg gaaaattacc ttttttgtgt catcttagca gctgttaaaa
      481 tatcgaatgg gggctgtgat ttatacaaaa aagcagtgtt tctctgtact cactttccca
      541 ttcactattc caagtaatcc ccccccacca acaccgtata ttgcttgatc atccttcacc
      601 tgaattgttc taatagcaac gttaaaaatt gctctgtcat cgtgaggcaa acacattcca
      661 ataaaatcac cctaaaatac gtcccgtatc atttcttaga agattgacaa tcatcatatt
      721 ttcagagcga ttcttactat cattagctaa ccaatgttta tttctaaaat cttgcgcatc
      781 attaatccca cgagcaatgg tagctttcat tggacgtatt gtcaattttg aaccattttt
      841 tcaaaaaata attctggact cattgataag atggcaaaat catcatgttc aatatactaa
      901 ttatatttgg caccttgttc aatcactatc cgattgtaaa gctcaaaaag attcgaatta
      961 attctattat gaagttgtac agtataatta acttgataaa tatttccctg acgaatttgt
     1021 tgtctaattt ctgagatagc tttctcatat tcatctttat ccgtcttaga ttcccaaact
     1081 tgtggcattg tgatattcat ctcgtcatca agaggaaaag tctttacaga aaaattgttt
     1141 tcaaatactt ttcctgcctc ataactgaca taaccaacaa cacaatatcc ttgtgaacta
     1201 ccttcttaag aatagcatct acatcaccaa ttaactttgt tgctaatatt cttactggat
     1261 tttcaaaaat taattggtgt cccaactctt tgaaatcaac cacagtcttt ttatgcatcc
     1321 aaactccttg tctttacctg cttttcttcc gcaacgacat cagctgtcct aagataaaaa
     1381 tagcaatcgc tatccagatg aaaataaaac cactaacttc tccattgcct accttttcgt
     1441 gaaaaacgaa cacggctatt gccagttgaa ttgtgggatt gatgtactgg ataaacccaa
     1501 tgatattcaa cggcgcacgt tttaccgctt ctgcaaacag caacaaaggg atcgctgtca
     1561 caatgccaga tgctaaaagt aacacgtttt ctagcaagct ataatctaat aaagtttctt
     1621 ttgaaaagaa tagcaaatag ataagcacaa aaggggcgac aacactactt tctaccaaca
     1681 tagcaacgtc actggataac ttgacatttt tcttaaccag tccatacaaa gcaaaggtaa
     1741 ctgctaacag tatcgaaaca agaggcggtt gccctgtatt aattgctaaa attcccacac
     1801 caatgcctgc aatgataatc gcagcagtca tccatggact caatcgttca tgtaggaaaa
     1861 ctaatgctaa taatattgac acaaggggca taatataata gccaaaacta gcttgtgttg
     1921 cctgctggtg actaactgca aagatataag ttaaccaatt caatgcaatc aaaaaacttg
     1981 ccaaaacagc catagcaagt tcttgcttat gactgataag ttggcgaatt tcaccacggt
     2041 atcgctcctt atttttggat aaaaccatgt aaaccaacat tgttaaaaca gtaaaaataa
     2101 tgcgataaga aaaggtgtta tatgaattaa cacctgaaag taatttccaa taaagggata
     2161 aaaagcccca caaaatatag gttattaagc caaacaaaat ccccaaatta gtctttttca
     2221 acaaaaactc ctttagtatc aacgtgaagt gcgacaactt caccatccaa agcaagcgct
     2281 gcaagacgct caacaagctc tgcttctttt gcttttggag ccaagaccat aatcgttgga
     2341 cctgcaccag ataggtaagt tgcataggca ccaaccttgt gagctacttc tttaatcggt
     2401 gcaaattctt taactaattt ttggcggaaa cgttcatgga aaaggtcagc ttcaatcgct
     2461 tttccagctt tttccaaatc acctgttaga agcgctgcaa tagctacatt ggcaattgat
     2521 gaggcagcaa cagcttcctt ataagaaaac tcatttggca atacattgcg gctatcgcta
     2581 gtctttaatt cataattagg aatgaacgcc acaaaagagg cttcaggaaa ggcaacaacg
     2641 gcactattga ccttttcatt aacataagat gaaataacaa gattaccaaa aatagctggc
     2701 gcaacattgt ctggatgccc ttcaattttt gtcgcaatca ccaatttttc atcagctgaa
     2761 agctgcaaat gagccagctg attagctaac tcaattccag ctacaataac tgatgaagac
     2821 gaccctaatc ctcgtgccaa tgggatatct gaaaccattt taatacgatg tggttgtagg
     2881 tcagctttca cttgtaaagc tgtcgtaatc aaaagattcg tttcgtcact aggaacatcc
     2941 cccaaatcat gtaaaacctc ccatctttca gaaagctcta aaatctcaat cgttaagtac
     3001 ttagaaaccg ctacgccgac cgaatcaaag cctggtccaa cattagcaga ggttgctggt
     3061 actgtaattt tcatatcatt atcatactca aaagtagtct tgagcttttc ctttcactta
     3121 atcagttatt attattcgcc taatacttta agtgtattaa ccacttggaa atcttctact
     3181 gcttccaatt tagctgttac atcagccaac tgtgttttac tcattgagtg tgtgatgata
     3241 accacacgcg cacgtgtacc attggctttt tgttgaagca cttgttcaaa tgaaatatct
     3301 tcagaattga aaatttcagc taaacgaagc aattgacctt ttttatcggg ggtattaatc
     3361 gcaaagtaat agtgactctt cacatcagcg ggatttgcca attttgtttc acgaacaaat
     3421 tcattaaatg gtttcccaac attaccgtct ttaatacgac gacaaatacg gataatatca
     3481 gcagttacag acgttgctgt tggtttttga ccagcaccag gtccataata cattgattcc
     3541 ccgataccga ttgactccac aaaaacagca ttcataacat cgttgacact agcaagtgga
     3601 tgtgcttttg gcaaaaaagt cggtgaaact tctgctgaaa tacctgattc aacttcacgt
     3661 acatctccga ccaatttgat gacatagcca agttcttgag cgacagcaac atcatctggt
     3721 gtgattgttg tgattccctt atgtgcaaca tcatcaaaat caatcgtcat tccaaaacca
     3781 aattggctta aaataacagc tttataggct gcatcgatac cttcgacgtc atttgttggg
     3841 tcactttcag cataaccaag atcttgagct gttttaagcg catcttcgta agtccaacct
     3901 tcgtcaacca ttttagtcat cataaagtta gatgtaccat taagaacacc caaaatacgt
     3961 gtaactttat cagaagtaag cgaattagca agtgtacgaa gaattgggat accaccagcg
     4021 acagctgctt cataatagaa agcaacaccc ttgtctttag caagttcaat taattcttta
     4081 ccatgagtgg caatcaagtc tttattggca gaaacaacat tctttcctgc ttcaagtgct
     4141 tttgtaataa atgtacgagc aggctcaata cgtcccatta attcaataac aatgtcaatg
     4201 ctatcatcac tcaaaatgtc atcaatattt gtaacgaaat tataatcatt tccagcagct
     4261 aataaacgat ttctttcgtc atcatctttg acaagaacct tagtgatttc aatcctgtca
     4321 tgggctgctt cagtaatttt tgatggattt tctttcaaaa ggaaaggaac accactggca
     4381 acagtaccaa aaccgagtaa agcaattttt attgacatct ttttctcctt aataagcaaa
     4441 tttcgaacag aaattgaact aaagtaccca atttcatttg tttatgtttg ttatcattaa
     4501 ataagacgca gtggttgagt gggttctaat tcgctgatca atcagctttt acaaccctac
     4561 tcaaactgtg cggaagtggg aataaaacag ttcagtgaac tgttttaggc aacaataaga
     4621 aattaaaact tattgaaaaa tcaagtttca aagaaactac tgatctctgt cccactctca
     4681 aataaaaaca tttcctacat tataccataa aattattcag aatttacaga aaaataacgt
     4741 cctttgaaaa tctttccata atttacaata aacagttccc tttgtcttaa aaaaatagta
     4801 caataggagt agacttttgc gaggagatcg ttaaatatta tggaaaaacg tcgtcaacat
     4861 caaaaacata gcaacaagcc attagctatt ataaatatta ttctattaat agcctgtatt
     4921 gtcgcaagtg tttttctttt tatagcttta aaggagaaca acttcatttt ttcaacaact
     4981 aaaaccgaac aagtgtcatc atcaagtgct agccatacaa atactaccac aacttcttct
     5041 gcatcaacgg tgacaagcga cagctcttct gctaatacca atgaaaacga ggttaactgg
     5101 gtaaaacagg attcaaatgt ctctgtaccc attcttatgt atcacgctat ccacgttatg
     5161 gctgcggaag aagcttcaaa tgctaatctc atcgtcgatc cgacaacatt tgaaagccat
     5221 attcaacgtc tttctgaaga gggttactac tttttaacac ccgaagaagc ctacaaagtt
     5281 ttaacagaaa atgtgcttcc aaacgacaat agtaaaattg tttggttaac gtttgatgat
     5341 agtctttggg atttttatga caatgcttac cctatcttgc aaaaatacgg tgcaaaagca
     5401 acaaacaatg tcattacaag cactgttgga aatagcggaa atttatcact tgatgaaatg
     5461 ttagaaatga aagcaaacgg catgtctttc caagaccaca ccgtgacaca tcccgacttg
     5521 tcagctagtg ataacgcaac tcagacttct gaaatggagg attctaaaaa ctatctcgat
     5581 accaatctta atcaagatac tatcgctatc gcctatccag ctgggcgtta ttctgacaca
     5641 acacttcaaa ttgcagcaaa ccttaattat aaactcggcg taacgaccaa cgaaggtatt
     5701 gccagtgcta gcgacggctt attatcatta gaccgtatcc gtatcttgcc gacaacaact
     5761 gctgatagcc ttatcgcaag tattagctaa catatcataa aagccccctt tcaaaaaaag
     5821 agggctttct tgctataatc gcattggtat cagcttattg ctatttattt ttcttatgat
     5881 ttttaacgaa actatagatt aagaaagcta aatttcctaa aaaaagcgcc gaccataaat
     5941 acacaaatac catatttaaa tgggcaatat tgtaaataat tgccacaaag aaaataatca
     6001 aatagatgac tgacatgtaa taaaaagaat tattttgcat acgtcacagc tccttcaacc
     6061 tgtcatatct catcataatt ttagaaagac tgtctattat tgggcaggga tctaaaattt
     6121 tttcgcatta cagaagaaac ttaccaaaac tagataaaac gaagcttaat tggattaaaa
     6181 ttttatactt atcttatcat tttgtaaaaa catttttatg tgggcattat tttatctata
     6241 ttttagatta gagtgataga atgagattaa tatatagcta taaaaacaag aaaatgaaag
     6301 ctatgaggac atcaaaatta aggatgttct tgatttgtca gacgtttcaa gacgaacatt
     6361 ttaccggcat tttgccaata aaaatgaatt gctaaatcac tattttgaac aaattatcaa
     6421 tcgttacctt actgaaagaa agtattttac cgaaacggat aattttcagg atatgttggc
     6481 taaatcaatg aacttttagc atcaagaacg tgaaatattg catatcttga taaaacacca
     6541 acactacatt ttttctttca ccaattcaac gagcatgcta aggaagttta tatgagcatc
     6601 acacttccat ggttcgctta tagcggagaa atcgataaaa agaactatac aaaatctagt
     6661 ttgctataga gtctgttttt ttattctaaa caatttgatc ctttttgaac acaaaaaaat
     6721 cgctactcct aggaatagcg atttaataag gttcattagc ctacttgagt agtcacccta
     6781 ttatttaaga gtaacaattg cacaacctgt taaatgtgca gtatcaaggg gtttgagttc
     6841 ataaatttga agtttggcag gaattttggc ataaaattga atccaaccct gcacttttaa
     6901 tattttgtgt gatttcttca gaaactgttt tatctaaagc attaaaccaa tgactatatg
     6961 tgttcattgt tgatttatca gcatgaccca ttcgtcttgc cacatataaa atatcttttt
     7021 tcaaaacatt tattagataa gaggcatgac tatgtctaag acctttccct gttataacag
     7081 gcactcctac ttgctgcgct ttacgtttga tgatgcgaca aatggttgat ttacaaaaag
     7141 gatctccaaa tcttgaaatg ataaaatctg tatcttgatt tgcaaactga ttttttcgcc
     7201 aaacttgaag tacttcaata gttatatcat ccaattcaat aagtcgttca cctgctggag
     7261 tctttgtttg gtctttacga taccaatttc cattttcatc tttctccaag gttgtatgta
     7321 cctttaggaa ttttttatca aaatcaatat cctcccaaca taaagataaa ccttcactca
     7381 ctcgtacacc tgtcatataa tataaccaga tggcagtaaa tcgttgtaat tcttcataat
     7441 catgtaagtc aaatgatttg ataaatgtct gaaactccgc ataggtccaa aatggagttt
     7501 ctggatgctt acctctagga ttatctaatg ctttacaagg catatctgaa atatagccaa
     7561 gtctttctgc ataacccata caagctttaa accttgacca taaatttttc gcatagtttt
     7621 cagaataatt ttctatgata tgtaatctaa aagcctcgca atctctagga gttattgctt
     7681 ttaatggctt agaaccaaaa taatgaataa aaagtttatg atgaggaaga gccgtcttat
     7741 atgtcacaga ctgaactttt tgcttatatg ctcttaaata aattgtgttc atatagtttt
     7801 caaaagtcat attgtaattt tctaaactga ctttgttggc aaattcatat tttatacgaa
     7861 ctaattcgtc atatgcttct ttcatcgttt caaaggtttt accatattga ttttttctag
     7921 ctttcttttg tacccttttg ccagttactg ggtcgattcc taaatcaatc tgataaaata
     7981 tctttccctt attatcacaa taaacacctt tgtatttttt actacttttt gttgtcattt
     8041 ggattctcac tttctaaatg ttatttagat agtggaatcc ctattaattg ttccacaatt
     8101 tctgctggtg cgatacctag tcttcgattg tcaaagggcg atttacttaa ttgtaccgca
     8161 ttatggtcaa ctttgcgagc ttcttcaaac ttttttacag caattctttt agcttcacga
     8221 ataatgtctc tagaggtatg ttcaggaaat cctaagttca ttaaatcttt atatgtagca
     8281 gttctcataa tctttcctcc ttcaaatcac taagtttttt tacacgctag atgggatttg
     8341 aatggttagt tcaatcatgg gaatttcacc cgctgtcctt ttacgatggc agcctgaacg
     8401 gtcagaagta tcattgtcat tatttgtgtc atggcagata ggttaccatc ctatttttga
     8461 ataaatgatt ttcgctcatt tcctggcgca ttacattcta ttgctcaaca aataaataaa
     8521 gtcccaccta gaattattca attgtcaatg ggcaaaaaga gactaaaaat tcctctcact
     8581 ataaagagtg aattttttag tctcctgttt cgttatcttt caaaaaattt tcgtaggttg
     8641 tccaaaattg tatttctcat ccgaaataga ctagtcgcag acatctcgtg ctctattgct
     8701 acttctctga tggtatgtcc tctaaaatac agagcatcaa taatttcaaa ctctttatca
     8761 gataaggtta ataaagcctc atttagttgc tcaataagga gcttggtttc tacaaaactt
     8821 tcaacatcaa cagtagtatc tggcagtata ttttctagtg gcaacccatc tacttcgaat
     8881 gatgtaaaag gtaacatgcc gaatttccta tcttttctat taagatattt ctcgtgattt
     8941 accaattgcc aataactttt ataaactgct tctgttacag gaattttact acctctaaca
     9001 tgaatataat atttcatttc atcctccttt tatgactctt ctaagtctta agaggagggc
     9061 tccttatttc aaccatagat atttctcact ttttattcag cttgagaagt tctcgccact
     9121 ataagagtga aaatatggtg cctttgttcc cataaaaaat atatgtaaaa aaacagcaag
     9181 ctctcctgaa cttgctgatc tatattttaa taagtttctg tttataggta acaataagat
     9241 attttgctat ataagcaatg taatacctag ataatctata atttattcta tgcgcgctat
     9301 tctaaattca ttattaatct caacagctat ggttccttct tctgctaaca aataaacttc
     9361 tccgtaatcc caaacttctc ttttttcatt agaattagaa ccagaataat ctattttatt
     9421 tagttctgat ttagaaattt cttgtcccgt attcaaaata aatgtttttg aatctgctat
     9481 tactcctaga aattctttta gtttatcatc agatacaata tcagatgaaa tacgaaattt
     9541 tttattatta aatttaacta tcctacaatc agatggatca attgcaagtt ccccacctgc
     9601 tgaattatta ttgaactctt ccaagctcag catttcatta ttggattgca catccgaact
     9661 caaagaaacc ttataataag aatcatttat agaaatagct aaaccatcac taaaattata
     9721 gagcccacta tatgctaatg atactgtatc actattactt ttagtaacaa ctttctggct
     9781 atttctatca attactaatg ttttaaaaaa agattccttc acagtaccta gatcattttc
     9841 atcaacaatt tgattcatga ttgtataatc atttccttta tatgtaaatt gattaaatga
     9901 ttgatcatga aactctattg ttttattgtc taccaatcta catgcaacta aagtgcaaat
     9961 tccaataaga acaactaagc taaataaaat tttcctcatg ctacttcacc tcctttataa
    10021 catcatcaaa taataagagt gccctttgcc aatttgttgt aacctttaag ttatttagtt
    10081 cgatcattgt taacagaatt ccaattattc catctaaata accaagatta tcttttgttt
    10141 ttatattttc aaattccgca gtagtattaa aaccatatgt catgtcttct ctaaaatcac
    10201 taattaactt ttccttaaga gattttatac agtcatcaaa atcagttgtt ttataaattt
    10261 ttttaaaaaa taggcaaatc tcaattgctc cagaaaatcc gtgacataaa atagattgtt
    10321 ccaaaccatt acttctcctg atggatgctt tcaagatgtt acaagcttta gattttagtt
    10381 tcttatcttc tagagccaaa cttgaataca gatatagtaa actaattcct gggctaccgt
    10441 agcaccacgc atctcgaata aattcatact gtaaattgct tttttctgtt ttctttagtt
    10501 caatatcgct taatccctct ttccacatat aattttttaa ctcgtgtttt tcgtataaca
    10561 ttataatttt tttgattgct gcaatagatt tttcattaga atagcctttt aattttgaat
    10621 aagacaacat tatgccaaca cccgcaaggc cgtgtgctaa accaaaattt agacatccta
    10681 acggataaag cttagactct gtcttggaca tttgattctt tgattccaca tagaagcctg
    10741 ttaaagtaga attttttagt gaaaactcag ataagaaatt gataattctg tttattatat
    10801 aatcattttc atcttgctcc tgagataaaa gataaactaa tattccagat actccttcta
    10861 tgatgtcata atctgtagga gagattttct taatatctat attttcaatc ttacttaacg
    10921 tatagtactt aatgtactca ttaaaactaa tcaataagtt atgatattct gggtgttctt
    10981 caactaaatg aagtatactt attccaattc cagaaactcc tgaaaataaa gaatccgata
    11041 aaacaccata atttctcatt tgtttaacca gaaagttaac atatttaccc gttctaacgg
    11101 agtattttct ttcactagtt aaacttgtca attctgaaga taataatatc aatccaggta
    11161 aaccagaaga caaggtcaat aaatcataat tcggttgttc agcatatctt tttaactgct
    11221 catcaaattt agcaaatact ttctcagata aatcaataat aactttattt tcatccatca
    11281 gactcctcct cgtacttttc tgaatagtaa agttccctat aatatttaga tttacttata
    11341 aggtcgtcat gttttccttc atcaataatt cgtccatctt gcataactat aattcgatct
    11401 gctctactcg cagccattag attatgtgac acaaacaaag caatcttatc tttagaacga
    11461 gttacaaatt catcaaatat ttctttctct gaaacaggat caagcgctga acttggttca
    11521 tccaaaatgt atatgcttgc attcttgaag aaagtcctag ccaatgctac tttttgccat
    11581 tgtcctcctg aaatttgtct actatcgtta aaccaggtcc ctaaacgttg attaaggttg
    11641 aaattgtttt ctgcggttaa gaaatttaat tttaagttat caatatgttt ctttattttg
    11701 gagtcagata tactgtttac atcacttagg ccaatatttt ctctcacaga taattcaaac
    11761 ttcacaaagt cctgaaaaag aacagaaaca ttattttgat aataactcaa gtctaggaca
    11821 tcactagatt cgttattata atatatttga ccctctgaag gttggtataa tcccgatagt
    11881 aattttacta aggtactctt accagaacca ttcttcccca caattgctac aagttcaccc
    11941 ttattaaact caacattaat atcctctaaa gttttttgac acttcctgga tagataaaag
    12001 agagattatt gacttttatt ttgtcaatgc gcttttcaat tcttgagatt ctactattct
    12061 gaattgaaat attacttatt tccatatcaa aaaatttaaa taattgttcc atgaataaac
    12121 ttgtgttata gatgatataa gtattttgga tcatagattg tgagtaggta tttacacgag
    12181 ttattgcttg aataaggctt acaaaattac ctactaaaag tttaccgctt cgaattgact
    12241 gtatcatcat aaaaatagct ataccattaa taaaattcaa taaaatatcc aaacttcctc
    12301 tgaaaagaac tttctttttc gaaatattca aatcctgatt cataaaattt cttttcaatg
    12361 ttccatattt atcaatgaaa tattgactaa taccatttag tttaatctct ttaaatgaaa
    12421 aatcatgagt aagaagataa ttgatgtacc aaacttccct ctccgaattt gctcgctccc
    12481 attgaatcaa aaattctagc tggccaacac gcataaaaat tactaaggaa ataacaggaa
    12541 ttatcagtaa aaaagtcgat actgccacat tccaagtgga cacataaata atacttgtta
    12601 ataaagatag aaaccctgta atcacaccaa tgatagcatt gaaaagttgg aacggcttat
    12661 atgtactatc ttgtacaata ttttcaatga gattgtatgt atctgcttgt tcaaaatcta
    12721 ttaaatttag agatgatgtt tttttcaata acttcaaatt gagattatag gacaagttca
    12781 tattaaattt ctcacttata tatgagttta actgacttag tattgatagc atcatttgca
    12841 ttaatatata gacaattaat actgaaaaaa tgttacttcc tttttttaaa acagcattga
    12901 ttaattcttg atagataaat aagcttgcta aaggaattat tgattgtaat atgtttaaaa
    12961 ttattagata gctagcatat tttctttcta ttcgaaaaat taatcttatt gttttaggaa
    13021 ttgtcaaaat tgtttgaaaa aaatttttta gtgtaaattt atccatgatt gtgcccattt
    13081 ctaaattctt cactgattat caatccgcga attatagcat aaatcttagt ctcattttct
    13141 ctctttatac caaataagcg attattgtgt acatgaatga tactatcata aatgatatat
    13201 gtatagtcat ctgacaattg aatacaactg tctgataatt tcttaagtct ttgacatagt
    13261 ttagatagtt ctggaagaag atttattaaa tatcccttta ttaagtacaa atcaattaat
    13321 gcagtattcc tatttttatc tctattttgg ctgtctaaat gctctggaca agcaaattct
    13381 aaaaattgta ttatttcttt attgttatct ttaaaaaatg atttgagata aaagtagtta
    13441 aatattattg ctaaatcatc tagggttaaa tctaatcttt tctgccgaat taaacttaat
    13501 gaattgatga ctatttcagt atctagacaa aaaatttctt ctaccaaagg aattctttct
    13561 agtcccccat acctttcgat ttctctgtca tacgttgaaa tatctatatt tgatattaac
    13621 ttgttttgta tgcagagttg aaaaatctct tgaatttttt caaaactttt atataaattc
    13681 tgcgttctta tccttagtcg gatatgaaat tttggatcag tatatctgat atagaagctc
    13741 atcccatcat ctaaatttac taacttcaaa atttgaggca ttatatccga aagaaattcc
    13801 tcttgcctat ctgccgacat atacaattta aagtagagcc attcatcaaa tggtattttc
    13861 tgtctaacat ttgtcggaat aacctctggt aatatttctt ttatgtacct aggttcctta
    13921 atttcatcct tagcaaatac tggaacaact atatcagaaa tatgagttgt agattccttc
    13981 tctacaaggt gtgaatcaaa aatacactct gatagacata attcttcatt tttattacta
    14041 ctttttctta caatatcttc aaaaagttga ttatctaatg gattattacg gttaattaat
    14101 attcgattat cactgttatc aacataaaat tttgtcggaa gattgttttc aagaataatc
    14161 tgatgaatat ccttcgacaa catccttcca ctaagcctcc aacgttcagg agcaacaata
    14221 atgtccttaa atactattct aggaatatga gaaaattttt gataaaccat ctcccaaggg
    14281 aatattccga aatgatcttc ttgagctatc tcacataaaa accgtaattc attgctaaac
    14341 atcatttggt tatacatatt tgtactataa aattttaaga gttccttagt tttgaaattt
    14401 ctagcataaa aactattctt agaatcaata ccaatatata tttcagataa aatttgactt
    14461 ctcttatcca tattcgtaaa aagtgataat actttttctc tgacatttgt tgtgcgcata
    14521 acattagcat gacgaagatt ctctggtaaa aatgttattt cacaagagtt ataccctgat
    14581 acgtgattat tgttttcaac aatttgagtg atagtttgat gataatgttc caatttatct
    14641 gatagaatag aaaacctgcc tgagctagct cctaagttct tagaacatcc tgtattagtt
    14701 aagcttagta cgcttttacc atctacttta ttaacataaa agaacaactc aaatcctaca
    14761 ttgattttat ctttgtcttg attaaaaaaa tcttcttcat tataaagttg aatatttcca
    14821 cctgtttcta aggctttttc aaaattattg agatattcta attcttcttt ttcactaaaa
    14881 tatacagtag aaggcgaaga ttcccagaaa tcatttttgg ggtgctgata tccatatgga
    14941 gaaccaattc ctaaattaga atcaaacaac tccatcaact gaacttctct atttactccg
    15001 tacttatcta aaaatttttc tttataatca tctaaataag tacgctttac atgatctgaa
    15061 ttacttacta gaaactcagc aaattctact atctgagttt tattttcatt acctaattgg
    15121 atttgaccat cattataaaa atcaatttga agaaaattag gggtttcaac taacgatgac
    15181 attaacttgt agatttcttg aagcttttca atcccatccc caatttccaa ttcagaatat
    15241 tcaacaatta agttgctaat tactattagt ttaaaataat aaagattttg cttatcgatt
    15301 tctttgactt tagaaatgaa ttcttcaaac ttaaaattca ttattaattc tgaattaata
    15361 tttgaaatta gaaaatgact atcaatcaaa ctcatgatat atgatgttgc aatatctcga
    15421 tactcttcac cataggattc aacaagtttt tctataatac agttaaaata tatatattta
    15481 tcacaacaaa gctcatcaat aagttgataa actttagtga actttatgtt gacttcttca
    15541 attttagtat catttataga aaacaattga acaactctat ctccaaattg atagttggct
    15601 ggatttattt tataggctaa ttctcgagaa tattccttct caatcttaaa aactagacgt
    15661 attaaccatt ctgaatccaa gagtactttt tttaatgttt ttccattcaa gtttaatttc
    15721 tctgtagaag aaaatgaacc tattgaagtt tcactaaata aaccaaatgg tgttgagcgc
    15781 tccttactac gcttataata tttatataca gattctgata attggttgat ttttttcctt
    15841 ttcattgaat caccactata atatttttga agcgattcat ataaactcct gctggctaca
    15901 aatagttgct cctggaatat cttattctct cttattgttt ctaaaaatga attataatca
    15961 cattccaaca attcatgtat tccaatgatt gcattacgaa ccaaaaaatt atttgtagta
    16021 tatttatgtt ccattagcag ctccaacttc taaattattt ttataaatct tcaaatatta
    16081 ttttggaaat ttataaaaat aaaggtagta gactactatc cactaccttt attttagcaa
    16141 tagacatatt cgtctaagga gtaatatcct aagcaaatat tctaatattt agagagacct
    16201 tactcgaaaa gacatagagt ccctttcttt cttagtcaaa atttgcaaac agatagttac
    16261 taaacaaata aattttatcc aaaatggcaa ccacaagttg cagttttgat tgcacaggtc
    16321 atcaaaatac ccgtcttaca tccaggagta cataatgatt tactagttac ccgaggtgaa
    16381 gctcctgagt tgttttcctt tgagattgtg acaagatcca aattaaaatc ttcattgttc
    16441 ataataaaat tcctccaatt attttttctt tgttcgaaca aatatattgt aagataccta
    16501 gttcagaatt tgttcataat tagagagaat gaacaaattt tttatttaga atgcatgaaa
    16561 tatttatact gatactctgg acaattaaat aaaaagatag ttgaccaatg aaactgctga
    16621 aaaagtctga tatttttaaa atatcatgaa caatactgtc ttgaaaagat aataaaatag
    16681 acataaaaag cggatgatct gcaatcttta gatttcaaaa tatgctgtca ttcgcttttt
    16741 atctattgaa ttttgttgta ttctactctt ttagtgacct ctaaccaatt tacctctttt
    16801 tacatatttt ttgaatttca acattattca taacagctaa attacaaaaa tacgataata
    16861 tgataaaacc aattaagtat actagaatca taaaaatttc atttttccca atttctagaa
    16921 tcatattaac aggtaaaacg ataggcaacc agaagatatt taaaaatact ttattggttg
    16981 caaatataat aaacagacat tcgataaaag aaattactag attccctccc tttcccatga
    17041 taagactaaa taacatatgt aaatggttaa gtaagactaa taataaccaa gtaatcacac
    17101 caacatacac aaagtaagag agtctattaa attcaactcc taccactatc caaactggaa
    17161 ctcccagtaa aaccataagt aagtctgtcg aaataagctt tattccccaa atcattctac
    17221 tatttttttc gctttttata ttttgaaaga aatttgcttt ttcctcttgt tcatgaagaa
    17281 aaatagagaa aattgatgct aatatacaat atcctaacat aggtaaaaaa atgatatttt
    17341 caattacaac tgaattattt gtaaactgta aataaagagg aattgtgaat aattgaataa
    17401 ttgataaaat taaaataaga tttaaagtaa gagagccttt caactttagc aactcacttt
    17461 ttagaatttt gttcattagt tatcctccac ttcaacaaac taaggaaact cacaaaaact
    17521 aagattgaaa gagatactga tattaaaatt gtcgatattt caactccact taatgctgcc
    17581 tctaaatcac ctgagggttt taaatgtaaa agagcataag caattttata gtgataagta
    17641 taaggaaata tgaaccaaac cgatgtctga gctattagag gagcaactaa taagcaaata
    17701 agagaatttg tagccaacaa caagtaggga tttatccact ttgctagaaa atataatagt
    17761 ggtaataccc aagcagaaga aacaccaata agtaataaac aaatcaaatc tttaccaatg
    17821 tctactgaca tcacacctga aaaaagaaat gagatgccat aaaatattat cataaaaata
    17881 aaggttgaaa tcaaaacatc cttgaacttc aacagtatct tcgctaaata aatagtaaac
    17941 gtatatctac ccaagctaat attttgaaac gcacctgcat tctcctccgc gctataatca
    18001 gctaaaaaca ataacccaag gagagtgaaa aggaatcctc cctcccacca ataaattgaa
    18061 aaactttcta aattgagagg tcctgctagt atgaaagcta taaaaattgc tagcaaagga
    18121 ataaggatta gtaatttttt atcagaacta gatttttgct tcagccactc agatttaaaa
    18181 atattagtca tttccatcac ctccatggac aattctaaag aataggtttt ctaaatcatt
    18241 tgaattctta ttagtatcat cgtaaaaaat cttgccctga ttcagtataa cgatttgatc
    18301 cgcaattttg ctgacttcac ttagttgatg gctggacaag aggactgtca ttccagattt
    18361 ttttagatcc ctaattaaat ttagcaattc ttttatccca tctggatcta gaccattagt
    18421 tggctcatct aaaattaata aatcaggatt ggtaataatt gccattccta aaccaagtcg
    18481 ttgcttcatt cctaatgaaa agtgccctgc cttctttttt ccagtatcag ataaaccaac
    18541 caactgaagt acctcataaa ttctttcatc tggaatatca tgtagcaatg ctcgtgtttt
    18601 taaattgtca aatgcagaaa gattcaaata gatagcagga gattcaatca acgctccaat
    18661 atcaaatcta ttttcttcta caatatcctt atgctttcca ttgaaaatga cttctccact
    18721 atcagctctt tctaacccaa aaagaatttt cataatggtg gatttcccag ccccatttac
    18781 tcccagaaga ccacaaatag taccttcttc aattttaaat gaaacgtctt ttaaaacttc
    18841 tttgtcttta tagctttttc ttagattttg aatgataact tccatttttt tgcctccatt
    18901 tcttttatta taatacaaaa gaaatttcag tatttgttca gaaaaaaaga ttgagcaaaa
    18961 agtcgatatc tcattgattt tttcaaattt tcgaaacaaa aaaccgcata aaatcaacgt
    19021 ttgtaaatga aagatttcat gcggttttgt ttatattagg ctttttgacc agcccctaaa
    19081 attttttaat taataaagta acctgtgcac caccattttg tggatttgag agtattaatt
    19141 gaccttgatg tctcatagct atcttttgag caaatgaaag tcctattccg taatgcttat
    19201 catttcttcc tttattctct gtgtaaaaaa gttttcctcc atctttaaga gactcttctg
    19261 taaatggtaa accattattc caaatctcaa aactgataaa gttagaactt tcagatatag
    19321 tcagtaccac cttgccctct tctgaacaaa atctagtcgc attagataag atatttatca
    19381 aagctcgatc taagttgaga cgatttcctt taatcactct ggtatgggat tcattaacta
    19441 tttgaaaatt aatttttttt gaagacataa tatctcgata ttctaatgat aattcatcaa
    19501 gaaattctgc taattcaata tcttcccgat aattcttatc ctcaattagc aaccttgagt
    19561 aattaaccat tgaattaaaa tacttttcaa atataccaac actatgattc attgaagaca
    19621 taaaatctaa ttgtttttca tctagattag tcatctcaag caactcgata ttccccttta
    19681 aaacagttaa tggtgtttta atatcatgtg ctaatgcagc aacttgaaat gacaaatctt
    19741 ctttatcttt tttctccatt tctaataact ttgtcaactc ttcgtctttt tgataaagcg
    19801 tcaataaaat gttattacat tctaggattt cagtttcttt atgtccaata tccattcctg
    19861 gtattcccat attcagagat attttttcaa ttaaacgaaa attttttgta aattctctta
    19921 agagcctgat aacggagata gagatgagta gtaactctag cactataaaa aacaaataag
    19981 agactaaatt ataggaaata tgtcgaaagt ttcgatttac aaattcgggc attgttggtc
    20041 ttctaataac caaaataaaa tctgagtttt catattctgt aaacaatata gaacccttgc
    20101 taaccgaact tccagtatca aaaacttctt tataatattg taaatcctgt ttttgatatt
    20161 ttccagagac caattcgcca ttatcgctat caaacaatac ataatcaaag acagagtaat
    20221 ccatttgatt cttaatactg ctagcagatt tactatcact aattgaaata tgatagtctg
    20281 ttccatatgt attcaactga cctgtaaaaa taagaacgta gctcaataca agcaacataa
    20341 taacatttgc aactgtacca atcactattt caaggactgt ccttaaaatc cgcttattaa
    20401 ttgaatatct tttcatcatt ccacttatat cccatccccc ttattgtttt aatgggatta
    20461 attccatagg gaacaaactt gactctaatt tgataaatat attccgaaat tgaacgaaat
    20521 aatgcatctg cttcatcatc atagacacat tcatagattt cttctcttgt ataaacctta
    20581 tttgtcttac tagataatag ctctaaaata tcatattccc ttttagtaag agaaatagct
    20641 tcaccattaa cacacacgag tttttcttga aggtaaaatg ttagtggaag taattctcga
    20701 ataacagatt cattagattc agcatttcta taacgttctt ctcgttttaa atgcgctgca
    20761 accttggcaa ctagttgatt aacactaaat ggctttgtta tataatcgtc accaccaaga
    20821 tttaagccag atacaatatc atcttcagaa tcttttgcac tgacaaaaat aatcggagag
    20881 gatactgatt tacgaatctg tttacagatt tgcagaccat caacattagg catcataaca
    20941 tcaagcaata ttaaatcaaa tccatcaaaa tcacttattt ttataggaag cctaacttct
    21001 tgataagtcg tcacattata gtttttcatt tctaaaattg ttcgcatcaa ttttacaatt
    21061 tcaaaatcat catcaactac caaaatctta tacatactag gtacctcttt tatctcatac
    21121 tactatttta cactattatt gcacaaaatt tgtaatattt agtagcctaa tttgtccatt
    21181 gtttccatta ttactaagaa aacaattatc atataaaatt cgaatagctt catctggttg
    21241 gtccttcaaa ttatactttt ctataatcaa tcctaaagct gcagagactt taggagtcga
    21301 aattgaagtc ccatatgcat atgtatactt tccttcaagc gttggaacaa gaatccattc
    21361 tttttcatat aatttatcag ctacccattt atcatatcct actttagaaa gcgcttgact
    21421 tccacctccc gttgcataga tatcgatgtc atcattccct tgatttgaga aactagatac
    21481 aagatcgtta tcatctactg aaccaactgt aacaacattg tctaattcag ccggaatatc
    21541 ttgtacagtt ccatcaactt gactataatc ttttcctctt aaactaccaa ggtagttttt
    21601 taattcatct tgattctgta aatccatccc ttcatcacct actgaagcaa caacaacgga
    21661 accttgatta tgagcataat taattgcccg ttgatagata ttgatcaaag ctgtatcatc
    21721 atcttcatca gtggaatctc ttaacaaata ttctcctaaa ctaaggttaa taacatcaac
    21781 atcatctttt gctgcttgaa tgagcgcttt gagaatccat tggtcttgag cattcccttc
    21841 atcaaaaaca cgatacattc gtattttcat gtcaggtgct atccctaaat attctccact
    21901 tgatgaaatt tgtcccacaa cagaggtccc atgcccaatt ttatctacaa cattttggtt
    21961 atcaactatt cctgtttcca aatctgatgt gaaattttgt actgaaataa tgtgtgaata
    22021 aatatctgga ttatcatatg taataccaga atctattaca ccaattgttg ctttaccaga
    22081 ggacttatgt tgaaatttac ttccagtact aatactcttt tgcatatccc actgatttcc
    22141 ccaaaaatct aaattagtat ttgtataaac cttgtcccca tacaaataag taatattagg
    22201 ctttacagtc atagtattat ctataactat gtcatcaata taattagagt tttctttttt
    22261 tattgtatct tcactttttt cggtagaaat agttaaaaaa tttatttcag gtattttatc
    22321 agtaacttta attccttggc tttgtaaaac atcttctacg tcctcaatag atttattttc
    22381 actaactaaa acattataac taatttcctt attttcatta gcacttactc ctgatgacac
    22441 agaaccgcta gctaatataa caataaacaa tgatataaaa acattcgaca ataagcctat
    22501 ctttttcata atatcatctc cttagttttt tattcctttt tatcaatttt atttcagaat
    22561 ttcttcagag tactcaatat ttggtatcaa taaatccgaa aaatgctatt ctttcacatt
    22621 ttttcactgt gttcaaattt tagttcatcc ttgcttgagt ctatttcatt taaaattttg
    22681 acaaactttt ccaacctcct tattaaatac tcataatcat ctattgactt atctaactta
    22741 atttgataga tttcgatttc tttctcaact tgttccagtt ttatagccgc agttagattc
    22801 atcttggcat agtcatattt ggccaagcgg cggttctcta tatcgttatt gtccaggtta
    22861 agcaagactt ccgcaacctt gttgagatga tctatgtgtt cctgaatctc tgtaatggtc
    22921 aaatctaatt gagcaatatc cttaataatc tcgtctttaa tatcttgata agacttattc
    22981 tccgtaccca actcaataag aagattaatc tcttcaatct ttttcttaag tgtatcaatg
    23041 gtcggtcttt ttcttttaga gatagtctgg ctatcattgg ttaactgacg aatgagttca
    23101 cgccctcgca tatagcgatt gagttcggac gcctccttat tgtaaatgaa aaattgtgcg
    23161 gtctcacgga taaaggcatg gtagtgttta ccactctctg tctctttaat atctaaatga
    23221 cggtttggga taaagaccaa gccatctttt ttaacgccgt aattcattct gataaagaga
    23281 ccatctttga ctaacttatc aatctgatgg tcagctaaga cgacctcaaa ctcttgagcc
    23341 tggtctcgtt tctccttaaa tgcctgataa gcctcttgca agtcttcata agctagcttt
    23401 tccttatctt gttcctcaca atatccctca aagtcggaaa taagttgcga ctggtcaata
    23461 tcaggaactt ctccacgttt ctcaaagtaa gtctcgaaaa attgaacatc gtagagattt
    23521 ttggaactga ctttttgatt attgactgta atgctctgac tattttttgt tagagtaaac
    23581 gccacattct tttgttttag agacatagca aggttgagtt ctcttgcaaa ctccaaaagt
    23641 tgtgaaaggt cacgaactct gggtaagaga aaatctaaac attgctcaat cgctcgcttg
    23701 gcaaagtgct ctcgaaagta ttcctcggta tagggttgac gtttatctag ttgcttgcct
    23761 ctaataactc gcttcatagg catatccgtc atcaaaaaac gcgcgtattt tcttgaaaaa
    23821 tcaatctgaa cattcaatgc ttctgccttg gataaaaagt cgtccaaatc cttactattc
    23881 tccatcagaa aataaagacg ttgcttcaat tcaaatttgt gattactttt gcgataggtc
    23941 acaaacttct catgagaata acggttcggt gtgataattt tggcacctgc ttctttggaa
    24001 agacggtcag aaatcatccg taaatttctc tcctgagcat aatcccattt gagtttctta
    24061 tgagaattga ggtcaacaga attgatgagg atatggttat gaacatgcga cctatccgta
    24121 tgggttgtca caataaagcg aaagtttccg ccagtcaact cctttatcgt ctcataacca
    24181 atacgattga tttcttcagg tgtaagatta tcctcaggtg agaatgactg gataagatga
    24241 tgagcatgaa ttttattttg cttgatttgt tgccggtcat ttctcgaatc ataaagccta
    24301 tcattattga ctaagtttgc ctgatacatc tcaactattt cttcataatt agggaagtcg
    24361 aggtaattgc tcattccaaa atctgaaacc aatttgagtt ggtcagtctt agctggattt
    24421 agaatatact tgataagact tttacggtat ttgttgccat gaaccgcaaa atgcttagtg
    24481 actaccataa aattccctca acttttgaca cttgacatag aagtccttat caacttccgc
    24541 aatcagctga cctatgcccg ttttcaaatt atctcgctgc tctactgtca gaagttttgt
    24601 ctgattgact gttttagcta tctggttaat gttattgcca attcgacgta attcaaaaac
    24661 cgagtcttgg tagttactgg tatcaattgt taaaaaggtc atatttggat taagcaaaac
    24721 ctttctggca taagcagaaa aattttgaca agaactttgg ctaatatgat tgttcaggtt
    24781 cgcaagttcc tggtctgtta aaaagacttt tttgagattg gttcgataac gattttccat
    24841 atctaacctc ccatatactt atctcgaaat tctgaactga gtggtactgc cttctctact
    24901 tctgtcatca gttcttgaac acaagtcaat ataattctta agtgttctga cgtgacctga
    24961 tggcctcgtt ccgctagagt cgctacctgt aaaatatctc tactgatttg ttctgttttt
    25021 tgagattgcc acagaataaa ccaatctctg atgtcatcct tgttattgac aatgtccaat
    25081 agtttttgtc tgacaaaggg agaaaactgc tccgcattct cctttctcat cagtagttga
    25141 atctgctcaa attcctcaag cgtcaagttg atttccttac gaattgtccg ataactttct
    25201 gtcatgatga tacactcctt ctcacatttc cctctagcgg gttagcaccg ataccgtatc
    25261 tgatacgggg gcttcctaaa agcctcaaat cttccctttt cggcttttgc gagctcagat
    25321 attgtgtcca caatatccca aaaatcatat cgccagcgga tcaaaatctt ccagttttga
    25381 cagctaacga taagataact tggtggctcc gcccccaaac ccccagtgaa aaatcatgga
    25441 ttgatttttt taggaatgat attaggataa tagaggtgat ttggaaaagg tatcacacat
    25501 gaaaaacgag ggtaagaaaa aagagagccg aagctctcag tgctatactt aagccaaact
    25561 attattgtga ttaactagtt cttcaaaaat aatttgaaat atatccttct ctataaaact
    25621 ccttagcatt cttatatttt cgaaagaatt tacatgtttt ctataagttt cacgtaaacc
    25681 acaattttct ataatatttt tatcttcctc tgatagcctt gacgttacat tttcaaatat
    25741 attatcaatt acctgaagta gctcgctctc cgttaagttt tgaaatttta tttttaaatc
    25801 aattctagag aatataggaa gtccaagttt ttctgctatt tctttatcat tacaaaaatt
    25861 tgttgttaat acaaatatac agttagaaac atctacagag taatttatat cttccaactc
    25921 cccttcgtca aacatttgat aaaaaacatt gtataaacca gtatttacct tgtcaaattc
    25981 atcaattaag acaatgtttg tttctcttga caataaatct tttgccaacg aact
//
