LOCUS       NC_016109              22532 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7063552
            Orig. end                         :: 7086084
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22532
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="36"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22532
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22532
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12532](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12532)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(133..147)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.23"
                     /tool="antismash"
     gene            307..1317
                     /locus_tag="KSE_RS31100"
                     /old_locus_tag="KSE_62870"
     CDS             307..1317
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139346.1"
                     /locus_tag="KSE_RS31100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62870"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_014139346.1"
                     /transl_table=11
                     /translation="MSTPPAAPPYPDTLWFTRCPVPTATGIAADRGWLAEEFAAEGIAV
                     RSLQDVPPEVAADHHYTHALTGLFREGGNVPALWARSRGERTRLIGLTWIEERQAILAR
                     ADSGITSAGQLRGLRLAVPRHPIAIDFWRAMALAGHHGALASAGLGWEDVESVDVEAAP
                     GGGQWEAELAALADGRVDAVYVKGALAVEAARRHGAVPAVELDALPDRRHRVNNGTPRP
                     ITVHQQLLDEQPELVARFLAVLLRAADWAADRPEDVARILGAETGAGPEGVAGAYAAGS
                     HRTLHPDLSADRLELLARQEEFLHAHGFLADRVDVHAWADPAPLAAARALLAARS"
     gene            1351..2385
                     /locus_tag="KSE_RS31105"
                     /old_locus_tag="KSE_62880"
     CDS             1351..2385
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139347.1"
                     /locus_tag="KSE_RS31105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62880"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_014139347.1"
                     /transl_table=11
                     /translation="MRTTVRRPLLAATALTAVAALALTACGSSAKDAGASADGKGGAQV
                     VLRVPDPGNSGFLAKGKKDGSLDKALAAAHAKVVWTGSAGPFAPAAQALNADQLDVAQG
                     SITSAVAALAQKPGFKLFAQIEPDVAGEGILVKNDSPIKEIKDLVGKKVAVSQGGTSEY
                     LLLKALEKNGIPTDKVERVYLRADQTSGVFNSGQVDAWATWGTFSIPAIANANAHFLAN
                     GKAVGSDNYAIWAVRSGFAEKHPEVVKAFYGYLHENAAKEKADPAGYLNVFTDAGPTAV
                     TPAEKEIAVDFGKQRAVDSPITDADAARFAVVAKFYADQGVTKSLVDVKPYLIDVNSLA
                     GSGK"
     gene            2382..3230
                     /locus_tag="KSE_RS31110"
                     /old_locus_tag="KSE_62890"
     CDS             2382..3230
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139348.1"
                     /locus_tag="KSE_RS31110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62890"
                     /product="ABC transporter permease"
                     /protein_id="WP_014139348.1"
                     /transl_table=11
                     /translation="MTTSTEQARAAGLVAPRARATATRPRGVSLALRTLGPLALIAAWQ
                     ISSATGALTPDVLASPGQVLQAVQELWGNGQLSDALSTSLTRAALGLLFGAGIGLVLGV
                     VTGFFRLGEELLDSAVQVLRTVPFLALVPLFMVWFGITETAKIALIGVATSFPMYVSAS
                     GGVRNTDRKLVEAMRSFGLSRWAIVREVVLPGALPALLSGLRLSMTLSVIALIAAEEIN
                     STEGIGYLMAQAQNFSRTDVLAVCILIYGLLGLAADGAVRVLERVLMPWRPTGARRGTG
                     R"
     gene            3227..4018
                     /locus_tag="KSE_RS31115"
                     /old_locus_tag="KSE_62900"
     CDS             3227..4018
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139349.1"
                     /locus_tag="KSE_RS31115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62900"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_014139349.1"
                     /transl_table=11
                     /translation="MSATTTTTTTATTPAVHLRGLRRVFGTRAVLDGVDLDIARGEFVA
                     LLGASGTGKTTLLRILGALDRADEGTVLVPPSRTVVFQEPRLIPSKRVLGNVTVGLPRG
                     AATKETGRRALAEVGLADHADAWPGTLSGGEAQRAALARALVREPELLLLDEPFAALDA
                     LTRLRMQDLVGELCRKHRPAVLLVTHDVDEAIRLADRVAVLRDGALVRDETVTVERPRD
                     AADPDFAALRRRLLADLGVHQDSAAPHVNAAPHVTAAQHVN"
     gene            4045..4962
                     /locus_tag="KSE_RS31120"
                     /old_locus_tag="KSE_62910"
     CDS             4045..4962
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139350.1"
                     /locus_tag="KSE_RS31120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62910"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_014139350.1"
                     /transl_table=11
                     /translation="MTVIVGVHRSNPSLYHLARLDYLQQELAPLGESAEFHHYADGTKT
                     GPYLADGTIDFGGTGSTPPITAQAAGHDIVYTAVSAPRPDHGALLVAADGPVHSVADLK
                     GGTVVLGIGSWQTHLLAKALDQHGLSYRDDITAERPAGDEAERLADGRIAGWIAQGAEL
                     AAARRTGAFRELIRTGDVITDRSVFFARRDLAVQRPEVVAAIVTALQRADHWAAANPAE
                     AAAIAAADQGGEAADWQTALAALPWRLEPATAEFVAEQQEAADIFHRVGFIERAVTVAD
                     IHLPELEQPVAAAVAAASPVAKEV"
     gene            4968..6038
                     /locus_tag="KSE_RS31125"
                     /old_locus_tag="KSE_62920"
     CDS             4968..6038
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139351.1"
                     /locus_tag="KSE_RS31125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62920"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_014139351.1"
                     /transl_table=11
                     /translation="MATEVLWYLIPREGHYPWEPEGRRPVDLGYLQHLAATVERLGYTG
                     ALLATDQYDVWTLGSALAAATGPGFQPLLAVHPGLVSPTLLAKMALSFEHLHGPGRLRF
                     NVVNGSTNQLREYGLHVEHDDRYRLSAEYWSLVKRLTSGEVFDHEGEFYQLKNAGGSLR
                     DLPPLREGRIPLWFGGSSPAGIEVAAEHVDVYLTWGEPPHLLKEKLEKVRERAAAHGRT
                     LRLGLRLHLIVRDTEEQAWAAADRLLDVTSEATYARQLGGRADEDGVGWQRQFRQHGGK
                     VPAHARELETHPNLWPGMSLFRPGPGTAVVGSTDQVVERLREYQELGVDTFILSGNPLL
                     EEAYRVAETVLPKLHP"
     gene            complement(6115..7104)
                     /locus_tag="KSE_RS31130"
                     /old_locus_tag="KSE_62930"
     CDS             complement(6115..7104)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139352.1"
                     /locus_tag="KSE_RS31130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62930"
                     /product="aldo/keto reductase"
                     /protein_id="WP_014139352.1"
                     /transl_table=11
                     /translation="MSFLPASDRYDSMTFRRAGRSGVQLPAVSLGLWHNFGDTQPLDVQ
                     RAVLRRAFDRGVTHFDLANNYGPPYGSAERNFGYLFAQDFRPFRDELFIASKAGWDMWP
                     GPYGDGGSRKYLLASLDQSLGRMGLDYVDVFYSHRWDPTTPLEETMGALDTAVRSGRAL
                     YAAISNYPAEQHREAVAILRELGTPCLLNQASYSILNREPEQGLLDAVGETRTALIAYS
                     PLAQGLLTDRYLSGDVPAGSRMSVGHFLKEEALTGAKLEQLRALAKVAEGRGQSLAQLA
                     LSWVLRDERVVSVIIGASSVRQLDQNLDALAAGPLTAEELAEIDRISR"
     misc_feature    complement(7210..7223)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.39"
                     /tool="antismash"
     gene            7253..7717
                     /locus_tag="KSE_RS31135"
                     /old_locus_tag="KSE_62940"
     CDS             7253..7717
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139353.1"
                     /locus_tag="KSE_RS31135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62940"
                     /product="group III truncated hemoglobin"
                     /protein_id="WP_014139353.1"
                     /transl_table=11
                     /translation="MTPPDTAKPDITSRADLEHALRLFYRAAFADPLIGPHFTQIARLD
                     LERHLPRITDFWESALLRTASYRGNALAPHAALHAAAPLTAAHFGRWVQLWRATLDGRH
                     AGPVTERAKAQSQRIAVAMLRRLGEPDTGGGSGGFVPLTAVRLASGGAAP"
     gene            complement(7773..9095)
                     /locus_tag="KSE_RS31140"
                     /old_locus_tag="KSE_62950"
     CDS             complement(7773..9095)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="KSE_RS31140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_62950"
                     /product="MFS transporter"
                     /protein_id="WP_014139354.1"
                     /transl_table=11
                     /translation="MADAPPTPLYRNPDYQRLWLAHALSAFGSQATYIALPLVLLAATH
                     SITDFGLVTFAEIVSSLFAGFPAGVLVDRLSRRTVMLFCDLARTAAFALFALVVLADRV
                     NLPVAVGLAVLNSLLGAPFGPAASAALRHVVPRGQLTTAVSMAQARSAVATLAGPMLGA
                     ALYAVTPVLPFVVDAASFAASALCVLFVRLPREAPGAGRPRAERPPFLKDLTTGLVEVR
                     RSAFLRYTLVNAALVNFVFSGIVVVLVAEGARSGPGGSYHNGLIIAMSGAGNLVGALFS
                     ARAGRTLAPRTLVLAVCWSTALLTPLLALGYGVLFTALVIGLCGLTSPAANAVISAARL
                     HSVPDHLLGRVQTACGIAPALFVPFGPLASGVLLDHFAGSTVLLLNAGVLLLLAAYSTV
                     SGGLRRIPDLREPRASEGPAPEPADRTPKGRLAEPHPVAGT"
     gene            complement(9265..9384)
                     /locus_tag="KSE_RS43690"
     CDS             complement(9265..9384)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="KSE_RS43690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_193365931.1"
                     /transl_table=11
                     /translation="MSEILKLQNLSVADTDEGELNEWSTISNYCHSKIEEDAV"
     CDS_motif       complement(9319..9384)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSEILKLQNLSVADTDEGELNE"
                     /locus_tag="KSE_RS43690_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9265..9318)
                     /prepeptide="core"
                     /locus_tag="KSE_RS43690_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-0.10"
                     /molecular_weight="1910.1"
                     /monoisotopic_mass="1908.9"
                     /core_sequence="WSTISNYCHSKIEEDAV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEILKLQNLSVADTDEGELNE"
                     /leader_location="[9318:9384](-)"
                     /alternative_weights="1928.1"
                     /alternative_weights="1946.1"
                     /alternative_weights="1964.1"
     gene            complement(9444..9563)
                     /locus_tag="KSE_RS43695"
     CDS             complement(9444..9563)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS43695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="class III lanthipeptide"
                     /protein_id="WP_193365932.1"
                     /transl_table=11
                     /translation="MSEILKLQNLSVADTDEGELNDWSTISNHCGSKIEEDAV"
     CDS_motif       complement(9498..9563)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSEILKLQNLSVADTDEGELND"
                     /locus_tag="KSE_RS43695_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9444..9497)
                     /prepeptide="core"
                     /locus_tag="KSE_RS43695_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.00"
                     /molecular_weight="1803.9"
                     /monoisotopic_mass="1802.8"
                     /core_sequence="WSTISNHCGSKIEEDAV"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEILKLQNLSVADTDEGELND"
                     /leader_location="[9497:9563](-)"
                     /alternative_weights="1821.9"
                     /alternative_weights="1840.0"
                     /alternative_weights="1858.0"
     gene            complement(9623..9742)
                     /locus_tag="KSE_RS43700"
     CDS             complement(9623..9742)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="KSE_RS43700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_193365933.1"
                     /transl_table=11
                     /translation="MSEILKLQNLSVTDTDEGELNDWSTISNHCGSKIDEEAL"
     CDS_motif       complement(9677..9742)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSEILKLQNLSVTDTDEGELND"
                     /locus_tag="KSE_RS43700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9623..9676)
                     /prepeptide="core"
                     /locus_tag="KSE_RS43700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="-0.10"
                     /molecular_weight="1818.0"
                     /monoisotopic_mass="1816.9"
                     /core_sequence="WSTISNHCGSKIDEEAL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEILKLQNLSVTDTDEGELND"
                     /leader_location="[9676:9742](-)"
                     /alternative_weights="1836.0"
                     /alternative_weights="1854.0"
                     /alternative_weights="1872.0"
     gene            complement(9800..9919)
                     /locus_tag="KSE_RS43705"
     CDS             complement(9800..9919)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038154.3"
                     /locus_tag="KSE_RS43705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthipeptide"
                     /protein_id="WP_193365934.1"
                     /transl_table=11
                     /translation="MSEVLKLQNLSVADSDEGELNEWSTISNYCGSKIDEEAL"
     CDS_motif       complement(9854..9919)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSEVLKLQNLSVADSDEGELNE"
                     /locus_tag="KSE_RS43705_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9800..9853)
                     /prepeptide="core"
                     /locus_tag="KSE_RS43705_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.00"
                     /molecular_weight="1844.0"
                     /monoisotopic_mass="1842.9"
                     /core_sequence="WSTISNYCGSKIDEEAL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEVLKLQNLSVADSDEGELNE"
                     /leader_location="[9853:9919](-)"
                     /alternative_weights="1862.0"
                     /alternative_weights="1880.0"
                     /alternative_weights="1898.0"
     gene            complement(10001..12532)
                     /gene="lanKC"
                     /locus_tag="KSE_RS31145"
                     /old_locus_tag="KSE_63000"
     CDS             complement(10001..12532)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="KSE_RS31145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_63000"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_148283181.1"
                     /sec_met_domain="micKC (E-value: 1.4e-230, bitscore: 766.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 2.3e-12, bitscore: 45.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7e-07, bitscore: 27.1,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRNHHLFAGDDPHFYDHPVHGAAKRRFAAVDRPVPAGWRSHQNG
                     SWFFLAPEGAELPDQGWKIHVSAVPAEAAEVIELVTAYCLEAGLPHKFLVSPRVHHLNN
                     GKYARRGSSGKLMTLYPADDERLRDALDGLGPLLAGRRAPYVLGDLRWQDGPLYLRYGG
                     FLERWCTLESGERVLAIARPDGTLVPDRREPYFELPQWLEPPECVAEQLRADEAAAAGQ
                     PGLPYLIERALHFSNGGGVYLARSRTDGGRVVLREARPLAGLDGAGADAVTRLRTEARA
                     LRALAGLEFVPRLLDEFTVWEHHYLAEEYVEGETLRQFLARSNPLTRPEPTAAELARYT
                     EQALDIVRQLELAIDQVHARGYAFGDLHPANVLLRPDGRICLVDFEVAHRPEHEPEPSV
                     ACPGFVAPHATAGFARDRYALDCIRLALFLPYTMLLDLQPAKVDQLADAMAEFFPVPTA
                     HTARVRSGLRRPSVRLPAPEDPFADPADTDGLTAALTRAILASATPHRTDRLFPGDPAG
                     LTDGGHTLEHGAAGVLHALHATGQPVDEEHADWLWRAARRSRDPRPGLYGGLHGAALVL
                     DELGHPQKALDLLDRAGRTDEPSLRNGLAGIGLTLHRLHRATGDGGLRDALDRTAERLA
                     ATLDPAAPPRDGAGLLTGPSGTASFFLHLHQDGGDPAHLDLAARALRADLARCRTSEEG
                     AVNLLDGTRLLPYLGSGSAGVGLLLGHYLRHRPEDEEFARALDGILLAARARLVIFGGL
                     FHGRAGLLALLAEHRDRPGTAEPLARQRRLLGWHAVPYGGGTAFAGDQLHRLSMDLSTG
                     TAGVLLALHAAAGAPLDLPGATLPALAAARP"
     gene            complement(12826..13032)
                     /locus_tag="KSE_RS31150"
                     /old_locus_tag="KSE_63020"
     CDS             complement(12826..13032)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS31150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_63020"
                     /product="hypothetical protein"
                     /protein_id="WP_014139356.1"
                     /transl_table=11
                     /translation="MNATRTARTVLAALLVAGLSAAVGLAVPAHSSPLGTTLRADGPQV
                     SATASPSPTATPTAHTDDVTWGQ"
     misc_feature    13273..13288
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(13473..14105)
                     /locus_tag="KSE_RS31155"
                     /old_locus_tag="KSE_63030"
     CDS             complement(13473..14105)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS31155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_63030"
                     /product="hypothetical protein"
                     /protein_id="WP_014139357.1"
                     /transl_table=11
                     /translation="MSVRTASPRSRAAGRALVLVAVGVSLAGCGLLGPGAQPVGTRSRE
                     VSEQQAERLLDGMREVLGEGRPVALDGQIRMFDGCSDGWRIAAEDEPYRLAIGMRVAVT
                     SEVLPARVRGLRDALAARGLRVGDYRESRPAAGQSMSEPWFTAELTTGDRQDRYTLEVR
                     VGDDTGAGDGKTTVLLTTVSACLEPGEAPAGSPSPSSSPAPSRVPVS"
     misc_feature    14214..14229
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     gene            complement(14278..14661)
                     /locus_tag="KSE_RS31160"
                     /old_locus_tag="KSE_63040"
     CDS             complement(14278..14661)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357860.1"
                     /locus_tag="KSE_RS31160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_63040"
                     /product="hypothetical protein"
                     /protein_id="WP_014139358.1"
                     /transl_table=11
                     /translation="MSTYVSVRGWVECDDRQLALVRELVERAERGPRRYRGGWSFPAEQ
                     PMWGNAVFFAADLRAGEEEHLRELLCRIAALPPSAPMREEDDDERVHGLFLVSHEADGP
                     SEWRLHGGGLHRAPLPAEHAYLV"
     gene            14777..16138
                     /locus_tag="KSE_RS31165"
                     /old_locus_tag="KSE_63050"
     CDS             14777..16138
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012371.5"
                     /locus_tag="KSE_RS31165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_63050"
                     /product="serine hydrolase"
                     /protein_id="WP_014139359.1"
                     /transl_table=11
                     /translation="MTEPGGAERWPYGADVPELLRAYGVPGCSVAVRDADGRERAWAFG
                     QRTAAGGGDRAVGTGTLFQACSLSKPVTALGVLLLAERGELDLDADVNERLAGWRIPPS
                     GGWQPAVTARRLLSHTAGLGPSGFPGYPAGAELPTLLQVLAGTAPANTPGVRPVGLPGF
                     GYAYSGGGTTVLQLLLESVTGRPAAELLRDLVLAPLGMTAARFATAVPADLAAHGHRRG
                     GAPVPGGWARHPELCAAGLWATPAELLRLAAAFQGPATPIGPAAARAALTPHAQVPPGG
                     ASLAGLDRVGLGLFLRTDPAGAVSWFGHAGGNDGYRCYLLAETGSGRAAAVMTNGDGGH
                     ALLSRLIPAIAAHHGWTGLDFTPPYDPPAPVPPGLRPGRWRRTADPAGPGLELALRDGR
                     LELDWPGQPALPLFTASATELLAEDVDLTARLTPAGTLLVEQGGHSVEFAPHEE"
     gene            16217..19615
                     /locus_tag="KSE_RS31170"
                     /old_locus_tag="KSE_63060"
     CDS             16217..19615
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018844355.1"
                     /locus_tag="KSE_RS31170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_63060"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_014139360.1"
                     /transl_table=11
                     /translation="MVRITVLGTLTAHVAGAATRLGGPRQRGVLAQLLVARGTAVPADR
                     LIDDLWDGRPPAKAATSLQAYVSNLRRLLEPARGPRQEARLLVSEAGGYALRGVRTDAQ
                     DFEDLLAGPGPGVDSGIDGDGAERLRRALALWQGPAYHEFADRPWAVPEITRLEELRTT
                     ARESAVEADLAAGRARSAAQAAAALVDDHPLREETWRLLALALWHAGRQAEALAAIRRA
                     RDYFAAELGLDPGPLLTAVESAILHQRTEDLAPRPRTTPAPAPATPAPAVPSAAPPAPS
                     ASDGALAVRGGPGAGRARVFVGRDGEVAALLGAAGRARGGAGFALVAGEAGAGKSTLLG
                     RVRESLEADGWRVVAGRCPESAGAPAAWAWTEVLRELAWHEPATASDPLLDPLLADPQP
                     SGRQDARSGRFRLHRAVVARLHDAARTAPLAVLLDDLHAADPETRELLGELAADQSFES
                     PAGGLLVVAALRPGEGELADVLARLARRSPVRVPLGGLAEPDAGRLIEAVCAAPVRPET
                     VRALAERTGGNPFYLAESAQLLALEGDSTALRQVPQGVRDVLRRRFERLPAPAVDLLRL
                     AAVAGRESDVDLLLRAGGQDEETATEAVEAAVAGGLLLEPRPGTVRFAHVLVRDTLYAD
                     LGGLRRARLHGRIGHALHGLRPGELAALAHHFTEAATAGTAALAVDHCVRAAEAAERRY
                     AHPSAVNLLRQAVDNLERAAERPGEDRAARRIDLLGALLRAQVRAGQVTAATETKAHAL
                     RLARESGREDLLIAAWTAWTEPTPWVTHPYGAFDREAVDQLTRLLRRTDLPPATRCRLL
                     DALTQELDCAGSPEAVTAGREAVAIARGEDDPRLLCLALTARARSCDHELAPIDRAEVA
                     SELAELAAEHDLPAYRWHAEHLAATAAAVHGDLPALRRHMAAAEEIAHRYGLAEFVDVV
                     LFQRGMLELAADRVEDAVALYERALTGLRERGSLHAGGLGALIRIVIAYRQGRLADTLP
                     LIEEHREQYGPLVADVTALALLAAGHGPEAARRARGEGHGIQADYFRSLFLHLRADLVI
                     ALDERAEAAELLDEMRPLAHLVAGAASTSIAIRPIALTLAELATHLGRTAEAAEYYRRA
                     AEVAHRWEAPGWAAEAAAGLRALQT"
     gene            19799..22021
                     /locus_tag="KSE_RS31175"
                     /old_locus_tag="KSE_63070"
     CDS             19799..22021
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035: MMPL domain-containing transport protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014139361.1"
                     /locus_tag="KSE_RS31175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_63070"
                     /product="MMPL family transporter"
                     /protein_id="WP_014139361.1"
                     /transl_table=11
                     /translation="MSTLLGRLGGAAAARPWRTVAAWVLLIVAVLGLAQVFGGEPHDDY
                     RVPGTRSTAGMDLLNARFPESSGTSARVVVHDRGGRALPAEPLEALRGRLAALPHALPV
                     GQPIPSRAGDTALLTVGYDVKVTAFKGSTGLDALREAARATTDAGYQVEFGGELPEHFS
                     APNGMAEGIGMAAALVILVVALGTVVAAGLPLLVALAGLGAGTGLITLLSALTDISNIA
                     PTVASMVGLGVGIDYALLLVSRHVEGLRRGLDARAAAAEANATAGSSVVVAGSTVLVSL
                     FGLKLAGLSVYASFGYATFATVGAVMAASLTLVPALAALAGPRLLRRAERRAPATAPAT
                     ATAPATAFAGQAPAAAPTRTERWARMIGRRPVAAAVLSLAVLLGLAAPLLGMRTWPQDA
                     GSQASGNTTRKAYDLVAAAYGPGANGPLLLAVDLGRLPEPELPALAARLAADPEVAAVQ
                     PARINAARDAAVISVQPKTGPQDEATAKLLERLRDHELPGGVEVTGQVAAFSDISDRLA
                     QRLWVVIPFVVVLSLILLTVLFRAPVIAVKAAAMNLLSVAAAYGVMTAVFQHDAGAKLL
                     GLPHAVPVSSWVPILMFTILFGLSMDYEVFLLARVREDWLATGDARGSVVRGLSATGRV
                     ISSAAAIMVAVFTGFAIDPDITVKMIGVGMAAAVLVDATVVRMVLVPATMTLLGRLNWW
                     LPRWLDRLLPELAIESAEPTGPAGSAQPAGSPSGTPAERPEPTVKV"
     misc_feature    complement(22121..22138)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 13.88"
                     /tool="antismash"
     misc_feature    complement(22223..22239)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.48"
                     /tool="antismash"
ORIGIN
        1 ctcaacggcc gtggttttcc caggatatgg gggtgatcac tgcggaagtg tgtcggcggt
       61 gttgcggctg cccggccttc tgtgaacagg tgatcccatc atctggcaag gcttgattcc
      121 accccggccg gatggaacgc tcagtccatc agccggttcg agcaggaggg agtccaccgt
      181 gaagacgcac cggtgccact cctcctgttg tcgctgaccg ccccgacgcc ctttccccgc
      241 cgcgccgttc ttcccatcat gcggaagatt ccgcgtgcgc ctcctgccga attccggagc
      301 cccgccatga gcacgccccc cgccgcgccg ccgtaccccg acaccctctg gttcacccgc
      361 tgcccggtgc cgaccgcgac cggcatcgcc gccgaccgcg gctggctggc cgaggagttc
      421 gccgccgagg gcatcgcggt ccgctcgctg caggacgtcc cgccggaggt cgccgccgac
      481 caccactaca cccacgcgct gaccggcctc ttccgggagg gcggcaacgt cccggcgctg
      541 tgggcgcgtt cgcgcggcga gcggaccagg ctgatcggcc tgacctggat cgaggagcgc
      601 caggcgatcc tggcccgggc cgacagcggc atcacctccg ccgggcagct gcgcgggctg
      661 cggctcgcgg tgccccggca cccgatcgcg atcgacttct ggcgggcgat ggcgctggcc
      721 ggccaccacg gcgcgctggc ctcggccgga ctcggctggg aggacgtcga gtcggtcgac
      781 gtcgaggccg cgcccggcgg cggccagtgg gaggccgaac tggccgcgct ggcggacggc
      841 cgggtggacg ccgtgtacgt caagggggcg ctcgccgtgg aggccgcgcg ccgccacggg
      901 gcggtgcccg ccgtggagtt ggacgcgctg ccggaccgcc gccaccgggt caacaacggc
      961 accccccgcc cgatcaccgt gcaccagcaa ctcctggacg agcagcccga gttggtcgcc
     1021 cgcttcctgg ccgtactgct gcgggccgcc gactgggcgg ccgaccggcc ggaggacgtc
     1081 gcccggatcc tcggcgccga gaccggcgcc ggaccggagg gcgtcgcggg cgcctacgcg
     1141 gccggcagcc accgcaccct gcaccccgac ctctccgcgg accgcctcga actgctcgcg
     1201 cggcaggagg agttcctgca cgcccacggc ttcctcgccg accgggtcga cgtccacgcc
     1261 tgggccgacc ccgccccgct ggccgccgcc cgcgccctgc tcgccgcccg ctcctgacct
     1321 tcccgacgac cccctctgtt ggagaacccc atgcgcacca ccgtccgccg cccgctgctc
     1381 gccgccaccg cgctgaccgc cgtcgccgcg ctcgccctga ccgcctgcgg ctcctccgcg
     1441 aaggacgccg gggcctccgc cgacggcaag ggcggcgccc aggtggtgct gcgggtgccc
     1501 gaccccggca actccggctt cctcgccaag ggcaagaagg acggctcgct ggacaaggcg
     1561 ctggccgccg cgcacgccaa ggtggtgtgg accggcagcg ccggcccgtt cgcccccgcc
     1621 gcgcaggccc tgaacgccga ccaactggac gtcgcccagg gctcgatcac ctcggccgtc
     1681 gccgcgctcg cccagaagcc cggcttcaag ctgttcgcgc agatcgagcc ggacgtcgcc
     1741 ggcgagggca tcctggtgaa gaacgactcg ccgatcaagg agatcaagga cctggtcggg
     1801 aagaaggtcg ccgtctcgca gggcggcacc tccgagtacc tgctgctcaa ggcgctggag
     1861 aagaacggca tcccgaccga caaggtcgag cgggtctacc tgcgggccga ccagacctcc
     1921 ggcgtgttca actccggcca ggtcgacgcc tgggcgacct ggggcacctt ctcgatcccg
     1981 gccatcgcca acgcgaacgc ccacttcctg gccaacggca aggccgtcgg cagcgacaac
     2041 tacgcgatct gggcggtgcg ttcgggcttc gccgagaagc accccgaggt ggtcaaggcg
     2101 ttctacggct acctgcacga gaacgccgcc aaggagaagg ccgacccggc cggctacctc
     2161 aacgtgttca ccgacgccgg cccgaccgcc gtcacccccg ccgagaagga gatcgccgtc
     2221 gacttcggca agcagcgcgc cgtcgactcg ccgatcaccg acgccgacgc cgcccggttc
     2281 gccgtggtcg ccaagttcta cgccgaccag ggcgtcacca agagcctggt cgacgtcaag
     2341 ccctacctga tcgacgtcaa ctccctggcc gggagcggaa agtgaccacc agtaccgaac
     2401 aggcccgggc cgcggggctg gtcgccccgc gggcccgcgc caccgccacc cggccgcgcg
     2461 gcgtctcgct cgccctgcgc accctgggtc cgctggccct gatcgccgcc tggcagatct
     2521 cctccgcgac cggcgccctc acccccgacg tgctcgcctc gcccggccag gtcctgcaag
     2581 ccgtccagga gttgtggggc aacgggcagc tgtccgacgc gctctccacc tcgctgaccc
     2641 gggccgccct cggcctgctg ttcggcgccg gcatcggcct ggtgctcggc gtggtcaccg
     2701 gattcttccg gctcggcgag gaactgctcg actcggcggt ccaagtcctg cgcaccgtac
     2761 cgttcctggc gctggtgccg ctgttcatgg tctggttcgg catcaccgag acggcgaaga
     2821 tcgcgctgat cggcgtggcc acctccttcc cgatgtacgt ctccgcgtcc ggcggcgtcc
     2881 gcaacaccga ccgcaaactc gtcgaggcga tgcgcagctt cggcctctcc cgctgggcga
     2941 tcgtccgcga ggtggtgctc cccggcgcgc tgcccgcgct gctctccggg ctgcggctgt
     3001 cgatgacgct cagcgtgatc gcgctgatcg ccgccgagga gatcaactcc accgagggga
     3061 tcggctacct gatggcccag gcgcagaact tctcgcgcac cgacgtgctc gccgtctgca
     3121 tcctgatcta cggcctgctc ggcctcgccg ccgacggcgc ggtccgcgtc ctggaacgcg
     3181 tcctgatgcc ctggcggccc accggagcac gacgggggac cggacgatga gcgccaccac
     3241 gaccaccacc acgaccgcga ccacccccgc cgtccacctc cggggcctgc gccgggtgtt
     3301 cggcacccgg gccgtcctgg acggcgtcga cctggacatc gcccgcggcg agttcgtcgc
     3361 cctgctcggc gcctccggca ccggcaagac caccctgctg cggatcctcg gcgcgctcga
     3421 ccgcgccgac gagggcaccg tgctcgtgcc gccctcgcgc accgtggtgt tccaggagcc
     3481 ccggctgatc ccgtccaagc gggtcctcgg caacgtcacc gtcggcctgc cgcgcggcgc
     3541 cgccaccaag gagaccggcc gccgggccct cgccgaggtc ggcctcgccg accacgccga
     3601 cgcctggccc ggcaccctct ccggcggcga ggcccagcgc gccgccctcg cccgggccct
     3661 cgtccgcgaa cccgaactgc tgctgctcga cgagccgttc gccgccctgg acgccctcac
     3721 ccggctgcgc atgcaggacc tggtcggcga gctgtgccgc aagcaccggc cggccgtcct
     3781 gctggtcacc cacgacgtgg acgaggcgat ccggctcgcc gaccgggtgg ccgtgctgcg
     3841 cgacggcgcg ctcgtccggg acgagaccgt caccgtcgaa cgcccccggg acgccgccga
     3901 ccccgacttc gcggcgctcc gccgccgcct gctcgccgac ctcggcgtgc accaggactc
     3961 cgcagcaccg cacgtcaacg cagcaccgca cgtcaccgca gcacagcacg tcaactagcc
     4021 tcccccgcaa gagaagagac cgccatgacc gtcatcgtcg gtgtgcaccg ctccaacccg
     4081 tcgctctacc acctggcccg actcgactac ctccagcagg agttggcccc gctcggcgag
     4141 agcgccgagt tccaccacta cgcggacggc accaagaccg gcccctacct ggccgacggc
     4201 accatcgact tcggcggcac cggctccacc ccgccgatca ccgcgcaggc cgccggacac
     4261 gacatcgtct acaccgccgt ctccgcgccc cgccccgacc acggcgcgct gctggtcgcc
     4321 gccgacggcc cggtgcactc ggtcgccgac ctcaagggcg gcaccgtggt gctcggcatc
     4381 ggctcctggc agacccacct gctcgccaag gccctcgacc agcacggcct ctcctaccgc
     4441 gacgacatca ccgccgagcg cccggccggc gacgaggccg agcggctggc cgacggccgg
     4501 atcgccggct ggatcgccca gggcgccgaa ctcgccgccg cccgccgcac cggggcgttc
     4561 cgcgagctga tccgcaccgg cgacgtcatc accgaccgct cggtgttctt cgcccgccgc
     4621 gacctcgccg tccagcgccc cgaggtggtc gccgccatcg tcaccgccct ccagcgcgcc
     4681 gaccactggg ccgccgccaa ccccgccgag gccgccgcga tcgccgccgc cgaccagggc
     4741 ggcgaggccg ccgactggca gaccgcgctc gccgccctgc cctggcgact ggagcccgcc
     4801 accgccgagt tcgtcgccga acagcaggag gccgccgaca tcttccaccg ggtcggcttc
     4861 atcgagcgcg ccgtcaccgt cgccgacatc cacctgcccg agctggagca gcccgtcgcc
     4921 gccgccgtcg ccgccgcctc cccggtcgcg aaggaggtct gagcgccatg gccaccgaag
     4981 tcctctggta cctgatcccc cgcgagggcc actacccgtg ggagcccgaa ggccgccgcc
     5041 cggtcgacct cggctacctc cagcacctgg ccgccaccgt cgaacgcctc ggctacaccg
     5101 gcgcgctgct cgccaccgac cagtacgacg tgtggacgct cggctccgcg ctcgccgccg
     5161 ccaccggccc cggcttccag ccgctgctcg ccgtccaccc cggcctggtc tcgcccaccc
     5221 tgctggccaa gatggcgctc tccttcgagc acctgcacgg ccccggccgg ctgcgcttca
     5281 acgtggtcaa cggctccacc aaccagctgc gcgagtacgg cctgcacgtc gagcacgacg
     5341 accgctaccg gctctccgcc gagtactgga gcctggtcaa gcgcctcacc agcggcgaag
     5401 tcttcgacca cgaaggcgag ttctaccagc tgaagaacgc cggcggctcg ctccgcgacc
     5461 tcccgccgct gcgcgaggga cgcatcccgc tctggttcgg cggctcctcc ccggccggca
     5521 tcgaggtcgc cgccgaacac gtcgacgtct acctcacctg gggcgaaccc ccgcacctgc
     5581 tcaaggagaa gctggagaag gtccgcgagc gcgccgccgc ccacggccgc accctgcggc
     5641 tcggcctgcg cctgcacctg atcgtccgcg acaccgagga gcaggcctgg gccgccgccg
     5701 accggctgct cgacgtcacc agcgaggcca cctacgcccg ccagctcggc ggccgggccg
     5761 acgaggacgg cgtcggctgg cagcgccagt tccgccagca cggcggcaag gtcccggccc
     5821 acgcccgcga gctggagacc caccccaacc tgtggcccgg catgagcctg ttccggcccg
     5881 gccccggcac cgccgtggtc ggctccaccg accaggtcgt cgaacgactg cgcgagtacc
     5941 aggagttggg cgtcgacacc ttcatcctct ccggcaaccc gctgctggag gaggcctacc
     6001 gggtcgccga gaccgtgctg ccgaagctcc acccctgagc caccgcaccc ccgcgaccga
     6061 acgggcgggc ggccgaactc cccccggccg cccgcccgtt cggcgctctt ccggctaccg
     6121 gctgatccgg tcgatctccg ccagctcctc ggcggtcagc ggaccggccg ccagcgcgtc
     6181 caggttctgg tccaactgcc gcacgctcga cgcgccgatg atcaccgaca ccacccgctc
     6241 gtcccgcagc acccaggaca gcgccaactg cgccaggctc tgcccgcgcc cctccgcgac
     6301 cttcgccagc gcccgcagct gctccagctt cgcgccggtc agcgcctcct ccttcaggaa
     6361 gtggcccacc gacatccgcg acccggccgg cacgtcaccc gacaggtaac ggtccgtcaa
     6421 taggccctgc gccagcggcg agtaggcgat cagcgcggtc cgcgtctcgc ccaccgcgtc
     6481 cagcaacccc tgctccggct cccggttcag gatcgagtag ctcgcctggt tcagcaggca
     6541 cggcgtcccc agctcgcgca ggatcgccac cgcctcccgg tgctgctccg ccgggtagtt
     6601 ggagatcgcc gcgtacagcg cccggcccga gcgcaccgcc gtgtccagcg cccccatcgt
     6661 ctcctccagc ggggtggtcg ggtcccaccg gtgcgagtag aagacgtcga cgtagtccag
     6721 gcccatccgg cccagcgact ggtccaggct cgccagcagg tacttgcggc tgccgccgtc
     6781 cccgtacggg cccggccaca tgtcccagcc cgccttcgag gcgatgaaca gctcgtcccg
     6841 gaacggacgg aagtcctgcg cgaacaggta gccgaagttg cgctccgcac tgccgtacgg
     6901 cggaccgtag ttgttcgcca ggtcgaagtg cgtcaccccc cggtcgaagg cccggcgcag
     6961 caccgcgcgc tgcacgtcca gcggctgggt gtcaccgaag ttgtgccaca ggccgagcga
     7021 gacggcgggc agctgcacgc cgctgcgccc ggcgcggcgg aaggtcatcg agtcgtagcg
     7081 gtcgcttgcg gggaggaagc tcatggccag catcctgcca ggtgagggcc cccgacggga
     7141 ccaacggccc tgcccgtgga cacccgcccc gacgtaccct ggccgggcgg agcagcgcgc
     7201 caccacccgt cacggcgcgt gaccgcggac gaccgcacca ggaggccccg ccgtgacacc
     7261 gccggacacc gccaaaccgg acatcaccag ccgggccgac ctcgaacacg ccctccggct
     7321 gttctaccgc gccgccttcg ccgacccgct gatcggcccg cacttcaccc agatcgcccg
     7381 cctcgacctg gagcgccacc tcccccgcat caccgacttc tgggagagcg ccctgctgcg
     7441 caccgcctcc taccgcggca acgcgctcgc cccgcacgcc gcgctgcacg ccgccgcccc
     7501 gctcaccgcc gcccacttcg gccgctgggt ccaactctgg cgcgccaccc tcgacggccg
     7561 ccacgccggc cccgtcaccg aacgcgccaa ggcccagtcg cagcgcatcg ccgtcgccat
     7621 gctgcgccgc ctcggcgaac ccgacaccgg cggcggcagc ggcggcttcg tcccgctcac
     7681 cgccgtccgg ctggcctccg gcggcgccgc gccctgaccg gcgggccgac cgggccggcc
     7741 gggctggtcc ggggcgggcc ggggcgggcc ggtcaggtgc cggccaccgg atgcggctcc
     7801 gcgagccgac ccttcggcgt acggtcggcc ggctccggcg ccggcccctc ggacgcccgg
     7861 ggctcgcgca ggtccgggat gcggcgcagg ccgccgctca ccgtgctgta cgcggccagc
     7921 agcagcagga cgcccgcgtt cagcagcagc acggtggacc cggcgaagtg gtccagcagc
     7981 acgccgctgg ccagcgggcc gaacgggacg aacagcgcgg gcgcgatgcc gcaggccgtc
     8041 tgcacccgcc ccagcaggtg gtcggggacg gagtgcagcc gggccgccga gatcaccgcg
     8101 ttcgcggccg gcgaggtcag cccgcacagg ccgatcacca gcgcggtgaa cagcaccccg
     8161 tagccgagcg ccagcagcgg cgtcagcagc gccgtgctcc agcacaccgc cagcaccagg
     8221 gtgcgcgggg cgagggtgcg cccggcccgc gccgagaaga gcgcaccgac caggttgccc
     8281 gcgcccgaca tcgcgatgat cagcccgttg tggtagctgc cgcccggccc ggagcgcgcg
     8341 ccctccgcga ccagcaccac cacgatgccg ctgaacacga agttcaccag cgccgcgttc
     8401 accagcgtgt accgcaggaa cgcgctgcgc cgcacctcca ccagcccggt cgtcaagtcc
     8461 ttgaggaacg gcggccgttc ggcccgcggc cggcccgccc ccggcgcctc cctcggcagc
     8521 cggacgaaca gcacgcacag cgcggacgcc gcgaacgagg ccgcgtcgac cacgaacggc
     8581 agcaccggcg tcacggcgta cagcgccgcc cccagcatcg gcccggccag cgtggcgacc
     8641 gccgaacggg cctgggccat cgacaccgcg gtggtcaact ggccgcgcgg caccacgtgc
     8701 cgcagcgccg ccgacgcggc cggcccgaac ggcgcgccga gcaggctgtt gagcaccgcc
     8761 agccccaccg cgaccggcag gttcacccgg tcggcgagca ccaccagcgc gaacagcgcg
     8821 aacgcggcgg tccgggccag gtcgcagaac agcatcacgg tgcggcggct cagccggtcg
     8881 accagcaccc cggccgggaa gccggcgaac agcgaggaga cgatctccgc gaaggtgacc
     8941 agcccgaagt cggtgatcga gtgggtcgcc gccagcagga ccaggggcag cgcgatgtac
     9001 gtcgcctgcg agccgaacgc ggacagcgcg tgggcgagcc acaggcgctg gtagtcggga
     9061 ttgcggtaca gcggggtggg cggggcgtca gccacggcgg tcctcccgga gccggatcga
     9121 gcgggggtcg aatggggaat cgggtggcaa cggaacggcc ggggcggccg gcgccgtcga
     9181 agggcaccgg ccgccccggc cgttcccggt cgcgccccac gggggtgagg ggccgcgacc
     9241 gggggcctgt ggagcacgcg acggtcagac cgcgtcctct tcgatcttgc tgtggcagta
     9301 gttggagatg gtgctccact cgttgagctc gccctcgtcg gtgtcggcga cggacaggtt
     9361 ctgcagcttc aggatctcgg acatggtgaa ctcctctggg gtgtctggtc gttggtcgtt
     9421 gtgcgcagta gtgcgaggac tgctcagacc gcgtcctctt cgatcttgct gccgcagtgg
     9481 ttggagatgg tgctccagtc gttgagctcg ccctcgtcgg tgtcggcgac ggacaggttc
     9541 tgcagcttca ggatctcgga catggtgaac tcctctgggg tgtctggtcg ttggtcgttg
     9601 tgcgcagtgg tacgggggct gctcagagcg cttcttcgtc gatcttgctg ccgcagtggt
     9661 tggagatggt gctccagtcg ttgagctcgc cttcgtcggt gtcggtgacg gacaggttct
     9721 gcagcttcag gatctcggac atggtgaact ccctggtttt ggttggttgt cggtgcgtcg
     9781 gcaatgcagg acgggctgct cagagcgctt cttcgtcgat cttgctgccg cagtagttgg
     9841 agatggtgct ccactcgttg agctcgccct cgtcgctgtc ggcgaccgac aggttctgca
     9901 gcttcaggac ctcggacatc gtgaactccc ttgtttcggt ggtgcgtcga ctcccgggcg
     9961 gtcgcccggg aggggcaggt ggggcccggc ggcagcgggc tcaggggcgg gcggccgcca
    10021 gggccggcag ggtggcgccg ggcaggtcca gcggcgcgcc ggcggcggcg tgcagggcca
    10081 gcaggacgcc ggcggtgccg gtggagaggt ccatcgacag gcggtgcagc tggtcgccgg
    10141 cgaacgcggt gcccccgccg tacgggacgg cgtgccagcc gagcaggcgc cgctggcggg
    10201 cgagcggttc ggcggtgccg gggcggtcgc ggtgttcggc gagcagggcc agcaggccgg
    10261 cccggccgtg gaacagcccg ccgaagatca ccagccgggc gcgggcggcc agcaggatcc
    10321 cgtccagggc gcgggcgaac tcctcgtcct cgggccggtg ccgcaggtag tggccgagca
    10381 gcaggccgac tccggcgctg ccgctgccca ggtaggggag cagccgggtg ccgtccagca
    10441 ggttgaccgc gccctcctcg ctggtgcggc agcgcgccag gtcggcgcgc agggcgcggg
    10501 cggccaggtc gaggtgggcc gggtcgccgc cgtcctggtg caggtgcagg aagaacgagg
    10561 cggtcccgct cgggccggtc agcagtccgg cgccgtcccg gggcggtgcg gccgggtcga
    10621 gggtggcggc gagccgttcg gcggtgcggt cgagggcgtc gcgcaggccg ccgtcgccgg
    10681 tggcgcggtg cagccggtgc agggtcagtc cgatgccggc caggccgttg cggagcgacg
    10741 gctcgtcggt ccggccggcc cggtcgagga ggtccagggc cttttgcggg tggccgagtt
    10801 cgtccaggac gagggcggcc ccgtgcaggc cgccgtacag gccgggccgc gggtcgcggc
    10861 tgcggcgggc ggcccgccac agccagtcgg cgtgctcctc gtcgaccggc tgcccggtgg
    10921 cgtgcagggc gtgcaggacg ccggccgcgc cgtgctccag ggtgtggccg ccgtcggtca
    10981 gcccggccgg gtcgcccggg aagaggcggt cggtgcggtg cggggtggcg gaggccagga
    11041 tcgcccgggt gagcgcggcg gtcagcccgt cggtgtcggc cgggtcggcg aacgggtcct
    11101 cgggggcagg gagtcggacg gaggggcggc gcaggccgct gcgcacccgt gcggtgtggg
    11161 cggtcgggac ggggaagaac tcggccatgg cgtccgcgag ttggtcgacc ttcgcgggct
    11221 ggaggtcgag cagcatggtg tacggcagga acagcgcgag ccggatgcag tccagcgcgt
    11281 acctgtcccg ggcgaagccg gccgtggcgt gcggggcgac gaaccccggg caggcgaccg
    11341 agggttcggg ctcgtgctcc gggcggtgcg cgacctcgaa gtcgaccagg cagatccggc
    11401 cgtccgggcg gagcagcacg ttggcggggt gcaggtcgcc gaacgcgtag ccgcgggcgt
    11461 gcacttggtc gatcgccagc tccaactggc ggacgatgtc cagggcttgc tcggtgtacc
    11521 gggccagctc ggcggcggtc ggctcggggc gggtcagcgg gttggagcgg gccaggaact
    11581 ggcgcagcgt ctcgccctcg acgtactcct ccgccaggta gtggtgctcc cagacggtga
    11641 actcgtccag cagccggggg acgaactcca gcccggccag ggcgcgcagg gcccgcgcct
    11701 cggtgcgcag ccgggtgacc gcgtcggccc cggccccgtc cagtccggcc agcggccggg
    11761 cctcgcgcag caccacccgg ccgccgtcgg tccggctgcg ggccaggtag acgccgccgc
    11821 cgttggagaa gtgcagcgcc cgctcgatca ggtagggcag ccccggctgg ccggccgcgg
    11881 cggcctcgtc ggcgcgcagc tgctcggcca cgcactccgg cggctccagc cactgcggca
    11941 gttcgaagta cggctcgcgc cggtccggga cgagggtgcc gtccggccgg gcgatcgcca
    12001 gcacccgctc gccgctctcc agcgtgcacc agcgctccag gaagccgccg taccgcaggt
    12061 acagcggacc gtcctgccag cgcaggtcgc cgagcacgta cggggcgcgg cggccggcca
    12121 gcagcgggcc cagcccgtcc agtgcgtcgc ggagccgctc gtcgtcggcc gggtacagcg
    12181 tcatcagctt gccgctgctg ccccggcggg cgtacttgcc gttgttcagg tggtgcaccc
    12241 gcgggctgac caggaacttg tgcggcaggc ccgcctccag gcagtaggcg gtgaccagtt
    12301 cgatcacctc ggcggcttcg gccggcaccg cggagacgtg gatcttccag ccctggtccg
    12361 gcagttcggc gccctcgggg gcgaggaaga accaggagcc gttctggtgg ctccgccaac
    12421 ccgccgggac gggacggtcg acggcggcga accggcgctt cgcggcgccg tgcacggggt
    12481 ggtcgtagaa gtgcggatcg tccccggcga acaggtggtg attgcgtttc acgtcgtcca
    12541 cccctttccg tgattcggag attcagcgat tcggtcattc ggtgattgtg gtgaatgcgg
    12601 agaatttctc ggcgatctcc ccggccggcc gccgccggaa gcggattccg gtgcggccgc
    12661 gcctattcgg gggagccggg tggatcaggc gacgacccag ccctcgttca ggttgcggcg
    12721 ggtgtcgccg aggacgcggt cggtgcgctc cgcggactcc ggcgagtcgg cgaggaagtt
    12781 cgacgtggcg tgcatagcgg gctccttggc gaagatcggt gggtatcact gaccccaggt
    12841 cacgtcgtcg gtgtgggccg tcggcgtggc ggtgggcgac ggggacgcgg tggcggacac
    12901 ctgcgggccg tcggcccgga gggtggtgcc gagcggggag gagtgcgccg gaacggccag
    12961 gccgacggcg gccgagaggc cggcgacgag gagtgcggcg agcacggtgc gggccgtacg
    13021 ggtggcgttc acggaattct ctcccctggt gaaatcgaat ctgctgcggc atcctccggg
    13081 ttttcccgga gtgttcccgt gccgtcggct ttcgggattc cgcgctttcg ggattccgcg
    13141 ctttccggtc tcgtgctccc cggcgctttc ctccctgccg acacctctac tctggcgcgt
    13201 ccggcggggg cgtggaaggc cgtcggggtg gacggaagtt gtcctggcac aagtcgtcca
    13261 ctcgtcccac ccgtcacacc ggcctcacca gcccccgggt gcacgcgaac cgccccgtgc
    13321 ccctccggtt cggcccggga ccggtccgga agcggcacgg acggcggtgg cacgggcggt
    13381 ggcgggggtc gcggggcggc ggcggagcgc tgaagcggcg gcggaacggg ggcggtcggc
    13441 ggccgtggac ggaagcggcc ccggccgcgc ggtcaggaga ccggcacgcg ggagggagcg
    13501 ggggaggagg acggggacgg gctcccggcc ggggcctcgc cgggctccag gcacgccgac
    13561 acggtcgtca gcagcaccgt ggtcttcccg tcgcccgcgc ccgtgtcgtc gccgacccgc
    13621 acctccagcg tgtaccggtc ctgccggtcc ccggtggtca gctcggccgt gaaccagggc
    13681 tcggacatcg actggccggc cgccggccgg gactcccggt agtcgccgac ccgcaggccc
    13741 cgcgcggcca gcgcgtcccg cagccccctg acccgggcgg gcagcacctc gctcgtcacg
    13801 gccacccgca tcccgatggc cagccggtac ggctcgtcct cggcggcgat ccgccagccg
    13861 tccgagcagc cgtcgaacat ccggatctgg ccgtcgagcg ccaccggccg cccctcgccc
    13921 agcacctccc gcatcccgtc gagcagccgc tccgcctgct gctcgctgac ctcccggctc
    13981 cgcgtcccca ccggctgcgc ccccgggccg agcagcccgc agcccgcgag cgagacaccc
    14041 accgccacca ggacgagcgc gcggccggcg gcgcgggaac gggggctggc ggtacgtacg
    14101 gacatgctgt tcttccctca catcgctgac ctgcacggcg gcccgccccg gcgccggcga
    14161 ccggcgggag gacggagtcc gtccgctaca cgcccgggcc cccgcccggg gttgtcacga
    14221 ctttccgacg ccccctgccg agccggggag ccgtggagcg gacagggcgc acaggaccta
    14281 gaccaggtag gcgtgctccg ccgggagcgg ggcgcggtgc agcccgccgc cgtgcagccg
    14341 ccactccgac gggccgtccg cctcgtggct gaccaggaac agcccgtgca cccgctcgtc
    14401 gtcgtcctcc tcccgcatcg gcgcggacgg cggcagggcc gcgatccggc acagcagctc
    14461 gcggaggtgc tcctcctcac cggcccgcag gtcggcggcg aagaacaccg cgttgcccca
    14521 catcggctgc tcggccggga agctccagcc gccccggtag cggcgcggcc cccgctccgc
    14581 gcgctccacc agctcccgga ccagcgccaa ctgccggtcg tcgcactcca cccagccccg
    14641 gaccgacacg tacgtactca tccgcgcagt atcgcagccc gaccgcccgc cgggccggcc
    14701 ggaaaaccgg gtggcagcgc gcccgcccgc cggtaacgtc accgaggagc ggtgaccggg
    14761 cgacggggga gggccgatga cggaaccggg cggggccgaa cgctggccgt acggcgcgga
    14821 cgtgcccgaa ctgctgcgcg cgtacggcgt gccgggctgc tcggtggccg tccgggacgc
    14881 cgacggccgc gagcgcgcct gggcgttcgg gcagcgcacg gcggccggcg gcggcgaccg
    14941 cgcggtcggc accggcacgc tgttccaagc ctgttcgctg agcaagcccg tcaccgcgct
    15001 cggcgtgctg ctgctcgccg aacgcggcga actcgacctg gacgccgacg tcaacgagcg
    15061 gctcgccggc tggcggatcc cgcccagcgg cggctggcag cccgccgtca ccgcccgccg
    15121 gctgctcagc cacaccgccg gcctcggccc ctccggcttc cccggctacc cggccggtgc
    15181 cgaactgccc accctgctcc aggtgttggc cggaaccgcg cccgccaaca cgcccggtgt
    15241 ccggcccgtc ggcctgcccg gcttcggata cgcctactcg ggcggcggca ccaccgtgct
    15301 gcaactgctg ctcgaatcgg tcaccggacg gcccgccgcc gaactgctcc gcgacctcgt
    15361 cctcgccccg ctcggcatga cggccgcccg gttcgccacc gccgtccccg ccgacctcgc
    15421 cgcccacggc caccggcgcg gcggcgcccc cgtccccggc ggctgggccc gccaccccga
    15481 gctgtgcgcc gccggactct gggccacccc cgccgaactg ctgcgcctcg ccgccgcgtt
    15541 ccagggcccc gccaccccga tcggccccgc cgccgcccgg gccgccctca ctccgcacgc
    15601 ccaagtaccg ccgggcggcg cctcgttggc cgggctcgac cgggtcggcc tcggcctctt
    15661 cctgcgcacc gacccggccg gcgcggtcag ctggttcggc cacgccggcg gcaacgacgg
    15721 ctaccgctgc tacctgctgg ccgagaccgg cagcggacgc gccgccgccg tgatgaccaa
    15781 cggcgacggc ggccacgccc tgctctcccg gctgatcccc gcgatcgccg cccaccacgg
    15841 ctggaccggc ctcgacttca ccccgcccta cgacccgccc gcccccgtcc cgcccggcct
    15901 ccgccccggc cgctggcgcc gcaccgccga ccccgccggg cccggcctcg aactcgccct
    15961 ccgcgacggc cggttggagc tcgactggcc cggccagccc gccctgccgc tgttcaccgc
    16021 ctccgccacc gaactcctcg ccgaggacgt cgacctcacc gcccggctca cccccgccgg
    16081 caccctgctg gtcgaacagg gcggtcacag cgtggagttc gctccgcacg aagagtgagc
    16141 gcaccccgcc tggaagccgc tcggaacgca ggtcggcgac ggtcgccgga cgccatcgca
    16201 taggctcgac cccacgatgg tgcggatcac tgtgctcggg acactgacgg cgcacgtggc
    16261 gggggccgcc acccggttgg gaggcccgcg ccagcgtggc gtgctcgccc aactcctggt
    16321 cgcgcgcggg acggccgtcc ccgccgaccg gctgatcgac gacctctggg acggccgccc
    16381 gcccgccaag gccgccacct ccctccaggc gtacgtctcc aacctgcgcc gcctgctcga
    16441 acccgcccgc ggcccccgcc aggaggcccg cctgctggtc agcgaagcgg gcggctacgc
    16501 gctgcgcggc gtccgcaccg acgcccagga cttcgaggac ctgctcgccg gccccggccc
    16561 cggtgtcgac agcggcatcg acggcgacgg cgccgagcgg ctgcgccggg cgctcgcgct
    16621 ctggcagggc ccggcctacc acgagttcgc cgaccgcccg tgggccgtcc ccgagatcac
    16681 ccggctggaa gaactgcgca ccaccgcccg cgagtccgcc gtcgaagccg acctcgccgc
    16741 cggacgcgcc cgctctgccg cgcaggccgc cgccgccctc gtcgacgacc accccctgcg
    16801 cgaagagacc tggcgcctgc tcgccctcgc cctctggcac gccggccgcc aggccgaggc
    16861 cctcgccgcg atccgccgcg cccgcgacta cttcgccgcc gaactcggcc tcgacccggg
    16921 cccgctgctc accgccgtcg aatccgcgat cctgcaccag cgcaccgagg acctcgcccc
    16981 ccggccccgc accacccccg cgcccgcgcc cgccaccccc gcgcccgccg tcccctccgc
    17041 cgcgccgccc gccccgtccg cgtcggacgg cgccctcgcc gtgcgcggcg ggcccggggc
    17101 cgggcgggcg cgggtgttcg tcgggcggga cggggaggtg gcggcgctgc tgggagcggc
    17161 cgggcgggcc cgcggcgggg cggggttcgc gctggtcgcc ggggaggccg gggccggcaa
    17221 gtcgacgctg ctgggccggg tccgggagtc cctggaggcg gacggctggc gggtggtggc
    17281 cggccgctgc ccggagagcg cgggcgcccc cgccgcttgg gcgtggaccg aggtgctgcg
    17341 cgaactcgcc tggcacgaac cggccaccgc ctccgacccg ctgctcgacc cgctgctcgc
    17401 cgacccgcag ccgagcggac ggcaggacgc ccgctcgggc cggttccggc tgcaccgggc
    17461 cgtcgtcgcc cggctgcacg acgcggcccg gaccgcgccg ctcgccgtgc tgttggacga
    17521 cctgcacgcc gccgacccgg aaacccggga gctgctgggc gagttggccg ccgaccagtc
    17581 cttcgagagc ccggccggcg gcctgctggt ggtggccgcg ctgcgccccg gcgagggtga
    17641 actcgcggac gtgctggccc ggttggcccg ccgctcgccg gtccgggtgc cgctcggcgg
    17701 cctcgccgag ccggacgcgg gccggctgat cgaggcggtg tgtgccgcgc cggtccgccc
    17761 ggagaccgtc cgggcgctgg ccgaacgcac cggcggcaac ccgttctacc ttgcggagag
    17821 cgcccaactc ctcgccctgg aaggcgactc caccgccctg cggcaggtcc cgcagggagt
    17881 cagggacgtg ctgcgccgcc gcttcgagcg gctgcccgcg cccgccgtcg acctgctgcg
    17941 gctggcggcc gtcgcgggcc gggagagcga cgtcgacctg ctgctgcggg ccggcgggca
    18001 ggacgaggag accgcgaccg aggccgtcga ggcggccgtc gcgggcggcc tgctgctcga
    18061 accccgcccc gggaccgtcc ggttcgccca cgtgctggtc cgcgacaccc tgtacgccga
    18121 cctcggcggc ctgcgccggg cccgcctgca cggccggatc gggcacgccc tgcacggcct
    18181 gcgccccggc gaactcgccg cactggccca ccacttcacc gaggccgcga ccgccgggac
    18241 ggccgccctc gcggtcgacc actgcgtccg ggccgccgag gccgccgagc ggcgctacgc
    18301 ccaccccagc gccgtcaacc tgctccggca ggccgtcgac aacctggagc gcgccgccga
    18361 acgccccggc gaggaccggg ccgcccgccg gatcgacctg ctcggcgcgc tgctgcgggc
    18421 ccaggtccgg gccgggcagg tcaccgccgc gaccgagacc aaggcgcacg cgctccgact
    18481 cgcccgggag agcggccggg aggacctgct gatcgccgcc tggacggcct ggaccgagcc
    18541 caccccgtgg gtcacccacc cgtacggcgc cttcgaccgg gaggccgtcg accagctcac
    18601 ccggctgctg cgccgcaccg acctgccgcc cgccacccgc tgccgattgc tcgacgcgct
    18661 cacccaggaa ctcgactgcg cgggctcccc ggaggccgtc acggccggcc gggaggccgt
    18721 cgcgatcgcc cgcggcgagg acgacccgcg gctgctctgc ctcgccctca ccgcccgggc
    18781 ccgttcctgc gaccacgagt tggcgcccat cgaccgggcc gaagtggcct ccgaactcgc
    18841 cgagttggcc gccgagcacg acctgcccgc ctaccgctgg cacgccgagc acctcgccgc
    18901 caccgccgcg gccgtgcacg gcgacctgcc cgcgctgcgc cgccacatgg ccgccgccga
    18961 ggagatcgcg caccgctacg ggctggccga gttcgtcgac gtggtgctgt tccagcgcgg
    19021 catgctggaa ctcgccgccg accgggtcga ggacgccgtc gccctgtacg agcgggcgct
    19081 gaccggcctg cgcgagcgcg gctcgctgca cgccgggggc ctgggcgcgc tgatccggat
    19141 cgtgatcgcg taccggcagg gccggctcgc cgacaccctc ccgctgatcg aggagcaccg
    19201 cgagcagtac ggcccgctgg tcgccgacgt caccgcgctc gccctgctcg ccgccggcca
    19261 cggccccgag gcggcccgcc gggcccgcgg cgagggccac ggcatccagg ccgactactt
    19321 ccgctcgctg ttcctgcacc tgcgcgcgga cctggtcatc gccctggacg aacgcgccga
    19381 ggccgccgaa ctcctcgacg agatgcgccc gttggcccac ctggtggcgg gcgcggcctc
    19441 cacctcgatc gcgatccgcc cgatcgccct caccctcgcc gaactcgcca cccacctggg
    19501 ccgcaccgcc gaagccgccg agtactaccg ccgggccgcc gaggtcgccc accgctggga
    19561 ggcccccggc tgggccgccg aggccgccgc cggcctccga gccctgcaga cctgacccga
    19621 cctgatccgg cccggcccgg tcccgggcac ccgaccggtc ccgggcaccc gaccggcccg
    19681 ggaacgccgg cgggcgccgg gccgccgact tggagcgggg ccgccaagtg gcctccaagc
    19741 agcgcctccc acactggggt tcgacaccgc atcgaccgct gcacggaagg ctcctgcaat
    19801 gtccacactc ctcggccgcc tcggcggggc cgcggcggcc cggccctggc gcaccgtcgc
    19861 ggcctgggtg ctgctgatcg tcgcggtcct gggcctggcc caggtcttcg gcggcgaacc
    19921 gcacgacgac taccgcgttc ccggcacccg ctcgaccgcg ggcatggacc tgctgaacgc
    19981 gcgcttcccg gagagctccg ggaccagcgc ccgggtggtg gtccacgacc ggggcggccg
    20041 cgcgctgccc gccgagccgc tggaggcgct gcgcggccgg ctcgccgcgc tgccgcacgc
    20101 gctgccggtc ggccagccga taccgtcccg ggcgggcgac accgcgctgc tgacggtcgg
    20161 ctacgacgtg aaggtcaccg cgttcaaggg ctcgaccggg ctggacgcgc tgcgcgaggc
    20221 ggcccgggcc accaccgacg ccgggtacca ggtggagttc ggcggcgaac tgccggagca
    20281 cttcagcgcc ccgaacggga tggccgaggg catcggcatg gccgccgccc tggtgatcct
    20341 ggtggtcgcg ctcggcacgg tggtcgcggc cggcctgccg ctgctggtcg cgctggccgg
    20401 cctcggcgcc gggacggggc tgatcaccct gctgtcggcg ctcaccgaca tcagcaacat
    20461 cgcccccacc gtggcgtcca tggtcggcct cggcgtcggc atcgactacg cgctgctgct
    20521 ggtctcccgg cacgtcgagg ggctgcgccg gggactggac gcccgggcgg ccgccgccga
    20581 ggcgaacgcc accgcgggct cctccgtggt ggtggccgga tcgaccgtgc tggtctcgct
    20641 gttcggcctc aagctggccg gcctgtcggt ctacgcctcg ttcggctacg cgaccttcgc
    20701 gaccgtcggc gccgtgatgg cggcctcgct gaccctggtg cccgcgctcg ccgccctggc
    20761 cggcccgcgc ctgctccgcc gcgccgagcg ccgcgccccg gccaccgccc ccgccaccgc
    20821 gacggccccc gccaccgcct tcgccgggca ggccccggcc gccgccccga cccggaccga
    20881 gcgctgggcc cggatgatcg gtcgccgccc ggtcgccgcc gcggtcctct cgctggcggt
    20941 gctgctcggc ctggccgccc cgctgctcgg catgcggacc tggccgcagg atgccggcag
    21001 ccaggcgtcc ggcaacacca cccgcaaggc gtacgacctg gtcgccgccg cgtacggccc
    21061 cggcgcgaac gggccgctgc tgctggcggt cgacctcggc cggctgccgg agcccgaact
    21121 gcccgcactg gcggcccggt tggccgcgga cccggaggtg gccgcggtcc agccggcccg
    21181 gatcaacgcg gcccgggacg ccgccgtgat cagcgtccag ccgaagaccg gcccgcagga
    21241 cgaggccacc gcgaagctgc tggagcggct gcgcgaccac gaactgccgg gcggcgtcga
    21301 ggtgaccggc caggtcgcgg cgttctccga catctccgac cggctcgcgc agcggctctg
    21361 ggtggtgatc ccgttcgtgg tcgtgctgtc gctgatcctg ctgaccgtgc tgttccgggc
    21421 gccggtgatc gcggtcaagg ccgccgcgat gaacctgctg tcggtggccg ccgcgtacgg
    21481 cgtgatgacg gcggtcttcc agcacgacgc gggcgcgaag ctgctcggcc tgccgcacgc
    21541 ggtgccggtc tccagctggg tgccgatcct gatgttcacc atcctgttcg gcctgtcgat
    21601 ggactacgag gtcttcctgc tggcccgggt ccgcgaggac tggctggcca ccggcgacgc
    21661 ccgcggcagc gtggtgcgcg gcctgtccgc caccggacgg gtgatcagca gcgccgccgc
    21721 gatcatggtg gcggtcttca ccggcttcgc gatcgacccc gacatcaccg tcaagatgat
    21781 cggcgtcggc atggccgccg ccgtcctggt ggacgccacc gtggtccgga tggtcctggt
    21841 ccccgccacc atgaccctgc tcggccgcct caactggtgg ctgccccgct ggctcgaccg
    21901 cctcctgccc gagctggcca tcgagtccgc cgagcccacc ggccccgccg gttccgccca
    21961 gcccgccggg tccccgtccg gcacccccgc cgagcggccg gagccgacgg tgaaggtctg
    22021 acccgcccgc tcccgcccgt gggccccgcc gtacgcacgg cggggcccac gggcgtgcgg
    22081 gggaccggcc ccggataagt cggatgatca tgacggcgtg ttaaatcgga cataacgtaa
    22141 cagttcggct ctaatatcct catgagcctc ctgcgtgaga acgccgttct cgccctcttc
    22201 ttctgcctgg gtctgggcta cctggtcgga aaactacgcg tcggaccgat ccaactgggc
    22261 ggcatctgcg gcgtcctgat cgtctcgatg ctggtcggag cccagcacgt ctcggtgaac
    22321 gccgacgtca agaacgtggc gttcgcgctg ttcatcttct cgctcggcta catcgccggc
    22381 ccgcagttct tcgccaacat gaacgccaag ggcctgcgct tcggcgtgct ctccgtcatg
    22441 gaggcggtcg tcgtcgtgct gatggcgctc ggcatcgcca agggcttcga cctcgacgtc
    22501 ggcaccgccg ccggcatcct ggccggcgcc gc
//
