LOCUS       NC_016109              24992 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6580669
            Orig. end                         :: 6605661
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24992
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="32"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24992
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24992
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14992](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14992
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    1..15
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(154..3669)
                     /locus_tag="KSE_RS29065"
                     /old_locus_tag="KSE_58730"
     CDS             complement(154..3669)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014805.5"
                     /locus_tag="KSE_RS29065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58730"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_014138940.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.7e-08, bitscore:
                     32.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHIVMLEVALTRGFGFVDDLVDAGAEVSVIVEDLRVYAGVPGFEN
                     RHRAARIIEVPSTRDVLDLAGSVRDRLGPNPVDGVVCVTEHCMPTAAALARDLGVPGES
                     LETVLLMRDKAAVRARLDAAGLGTLRWRTAGSAAEGLAAAAGLGYPLVVKPNAGWASQG
                     VTVAWRPEQVERALRAAFAPPAAAPAAFAPGPDQVLLEEFRFGRHISAELLVQDGRILF
                     YGFSERLPSRPGTTAELGGHFPAEFEQRGAAREFVREVVEALGVRNSPMHIELLVTPTG
                     PELLEVNGRIAGHAVTRQLELALGRSVTADLAALAAGRPVPEVDEPVAAVALRQLWSPY
                     PGTVRAVALPAAAPEVAELRVGVAPGDRVRALDCNYDRYGHVLAVGGTVAEACAAADRA
                     AAAVRVEIERDATADTADQASPDRTDGAPHLLLVLDPAAEGSAELAPERVLAALGGATG
                     RLSVLWTGPAADAAPLRARWERRYAGEWLDAPDEAAAHRALAALRERRPVDAVLGCSPG
                     AARLAELLEGCPALPGAPEPQAAPASAPGTAPGLRVVSYLDGGTVRHLGVYEELPAEPD
                     GSRSLLWRAGPAAAELPAGLLERAEAAARRTGPARGLVRYPDGADRVLPGLDQDARALL
                     DAVFPRPVLALAATAALGLGTVWPEPRPGSALVRVLAAPPGRFRVVAAPEPGPLRDEPA
                     VASVDAPPAAGRVLDGAAVWLRYAVTGADAAACRAVAARVESFTALRHESLARTHVLLV
                     DRSGGRAWTDEDGSAVLPADRYRVSVIGAPPVLAAPVDLAHQADPFDLSALDSAADAIH
                     AVHPVDRVSAGSERLLGPVAELRSRYGAAGDDRDFTRSVRDKALMKRVARAAGIRHAPG
                     GVLHEPALARELLARYGAVVLKPRELSGSQGVAVCRDEAALDRWLRERFTPGQQLAEAF
                     VDAPMCHLDAVVHDGSLLWDVSVYRRDTLAFTRGLPLSSLAPDDPVLRAAAGRLVEQVV
                     EAWRIRSGVLHVEAFVEPDGLTLCEVAARPGGGGIVPAFRATRGVDLRHAKVLIDAGDS
                     PWRLRRDPVGAYAGWTVHYASDGRLAEFDDSAVAAAAVHRAVAGRVGELLPASDFSGTG
                     LSTHVFAADSAARVDELVTLAESAVRIRIEPVGATAGATADGAADATAGGAATVPVPEP
                     AGVAR"
     gene            3925..4509
                     /locus_tag="KSE_RS29070"
                     /old_locus_tag="KSE_58740"
     CDS             3925..4509
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0008752 - FMN reductase (NAD(P)H) activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0052873 - FMN reductase (NADPH) activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138941.1"
                     /locus_tag="KSE_RS29070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58740"
                     /product="NADPH-dependent FMN reductase"
                     /protein_id="WP_014138941.1"
                     /transl_table=11
                     /translation="MSTEPLRVAVIIASVRKGRSGPTIANWFTGVAGRRGSLAVDLVDL
                     ADYDLPNSLTDQPDQELAAKLADIGGRLDRAEAFVVVTPEYNHSFPASLKALIDWHTTQ
                     WQAKPVGFVGYGGLAGGQRAIEHLRQIFAECHMVSVRDAVGFHSHWGLFDNEGNLIDPT
                     HHESAAKSLLDGLEWWGTALRDKKAQQPYGS"
     gene            4515..5789
                     /locus_tag="KSE_RS29075"
                     /old_locus_tag="KSE_58750"
     CDS             4515..5789
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="KSE_RS29075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58750"
                     /product="MFS transporter"
                     /protein_id="WP_051055415.1"
                     /transl_table=11
                     /translation="MPTTRRTGAGVGAGTGTGTVAGRTTARTAARPATARPAAGRSRSA
                     GPPVAGLVAALALVGTLVVGQLYATIPLLPRLGAAWGVPGSTATWATSAFAAPYAVVSL
                     LSGQLARRYGTRAVAVTGVVVLALATACVPFGGGLAAGLALRAVQGAGAGVYVPMAYAC
                     LNARVAPARLPFALTVVSACMAGTVVTGQLESQLLASLLGWRGVFLAWAPLLLLGAAVL
                     HRTLPADRPGRSAAVPAARPAIRPVRLLPLYLAALLCSTGMTAVYTGLQLYGPPALVRD
                     DQAMLALRATALPALLTAVLLAPLLGRVPAPRRATAGFALAALGALGTAATGRHTGGLA
                     LALAVFMLGVATVGPALVQHLGARTTGTPNAPTAMALYGFTLNIGGALGAQLPKATATT
                     TGLGCLLATLLTTCAALLATHRTPP"
     gene            6220..6342
                     /locus_tag="KSE_RS45950"
     CDS             6220..6342
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS45950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255519007.1"
                     /transl_table=11
                     /translation="MLNVLHQVFARCRCAHEWDDFDTAMRALAFDGLLSGITWD"
     gene            complement(6414..6635)
                     /locus_tag="KSE_RS29085"
                     /old_locus_tag="KSE_58770"
     CDS             complement(6414..6635)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138944.1"
                     /locus_tag="KSE_RS29085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58770"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_014138944.1"
                     /transl_table=11
                     /translation="MNAPKADLYAYDLSGAVWRKSSASGGEGECLEVTDLPGGGRAIRD
                     SKNPDRTPLCFTAREWEAAKAGILAGEL"
     gene            complement(6632..7504)
                     /locus_tag="KSE_RS29090"
                     /old_locus_tag="KSE_58780"
     CDS             complement(6632..7504)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138945.1"
                     /locus_tag="KSE_RS29090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58780"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_014138945.1"
                     /transl_table=11
                     /translation="MSNSPLVPTVRRRQLGKALRGLRNTAGLTLDGAAETMGWKGPKLS
                     KIENATQSLRPAELAGLLTVYGVSDPEVSTALDSLAKDAGKRGWWQTYGGVLSPAYADY
                     ISLETDAESIRIYSPGLIPGLLQSAAYARETIAAIAMTRTPEEVTALAEVRQARQAVLS
                     RTGRPPLELWAIIPEAVLHQRFAVRPAIMREQLQRLLDAAELPNVTIQVMPLEATLHPG
                     TIGGFNLIGFPGPLPDVVQLENLLGSSYVEDADGVKLHAAAFERIQAAALPPEDSLALI
                     ARMEEGTRK"
     gene            7705..8127
                     /locus_tag="KSE_RS29095"
                     /old_locus_tag="KSE_58790"
     CDS             7705..8127
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS29095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_58790"
                     /product="ATP-binding protein"
                     /protein_id="WP_014138946.1"
                     /transl_table=11
                     /translation="MDAAADELLQSEPGFYVQDGAAGVIVHLVADRGSLARMRRLAVFR
                     LGKAGIGLDLAQDAELLVSELVGNAVRACGDGVPLVVEVATGTDGVRVRGHDPEPGELP
                     RRCGTTAGDRQAEGGRGAAARFGTCAGLGGRLDAGR"
     gene            8442..9665
                     /gene="fxlM"
                     /locus_tag="KSE_RS29100"
                     /old_locus_tag="KSE_58800"
     CDS             8442..9665
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138947.1"
                     /locus_tag="KSE_RS29100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58800"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_014138947.1"
                     /sec_met_domain="PCMT (E-value: 4.1e-36, bitscore: 123.5,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSIDDSLVRDPGVLRSDMVRALREQDGIRSEPVAAAFAAVPRHR
                     FAPEAPLELVYDPHRTVPVKKDENGLELSVMSAAHLQAVMLEQAGVEPGMKVLEIGSGG
                     VNAAYLQELVGKAGEVTTVDIDCDVIDRARRCLDDAGYPQVRTVLADGESGVPDGSPYD
                     LITVTAAAWDIPPSWISGLAPSGRLVVPLTVCGTTRSIAFDRDRGPESDDEGLVSRSYS
                     LARFVPMQGEGAAEERRVLLREGVAVQTDDVRVPLDAQALNRALDGPRLECWSGAAYDL
                     PDELELYLTFNLSSPARLHAANDVVERGLVEASALFGVPVLVSEDSFAYRTRRENADTG
                     GFESGVVAHGPGAQALADEYATLLRRWARDHRRRGAATFRYLPGPVPVPLPRNAVRRRH
                     GIVTATWR"
     misc_feature    complement(9730..9743)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: medium, score: 18.34"
                     /tool="antismash"
     gene            9733..9915
                     /locus_tag="KSE_RS29105"
                     /old_locus_tag="KSE_58810"
     CDS             9733..9915
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009322874.1"
                     /locus_tag="KSE_RS29105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58810"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_033258224.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.9e-17, bitscore:
                     61.7, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVQLEGPIASARPADEQYDLADFELDITIVEGGPAADQLIRLTN
                     DGCNSTCATACVSCP"
     CDS_motif       9733..9846
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTVQLEGPIASARPADEQYDLADFELDITIVEGGPAAD"
                     /locus_tag="KSE_RS29105_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9847..9915
                     /prepeptide="core"
                     /locus_tag="KSE_RS29105_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.90"
                     /molecular_weight="2180.5"
                     /monoisotopic_mass="2179.0"
                     /core_sequence="QLIRLTNDGCNSTCATACVSCP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTVQLEGPIASARPADEQYDLADFELDITIVEGGPAAD"
                     /leader_location="[9732:9846](+)"
                     /alternative_weights="2198.5"
     gene            10001..12895
                     /locus_tag="KSE_RS29110"
                     /old_locus_tag="KSE_58820"
     CDS             10001..12895
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020123798.1"
                     /locus_tag="KSE_RS29110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58820"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_033258225.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.4e-21,
                     bitscore: 75.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.2e-110,
                     bitscore: 368.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-25, bitscore:
                     89.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRHIDAALVRAAAWNLDHQTSWPDLVSERADPESWRAWLQQAWQ
                     KQDFAGAVTVASPDLASRVEQIRTGRPIQSADVRRTVLAVLRYLLRARTRATPFGLFAG
                     VAPARIGATATLRVGNEHHATSRTDAASSTALIDRFEQHPALRTHLVLTASTLAVERDG
                     HVVIEHLPSGTAEVGPQHVHVRLTAPVRAALQGARAPIGWGYLAAQLADAFPSAPVIVI
                     DKLISGMVEQRLLVTSLRPAMTVTDPLAALHGHLSHLPPVDADEIRRTPRNMVDLRVDW
                     KLTVPEVVATEAAAAARALTRLAPRAALTGWAEWHGRFLERYGPQATVPVLEAVDALGY
                     PSGFLGATTAPTTSPLPERDGRLIRLAHSAGMQRRLEVELDDAALEELAATHPGHPVQP
                     STELTVRIHATSLPALQGGEFTLHVVGVARSAGATAGRFLDLLGDTDRDRMTKAYAELP
                     AVHRGALLAQISSPPLSTRAGNVARAPQAADLVISLGEHHSQDTGLVPVTDLAVTADAE
                     QLHLVSLSRDRPLHTLLLNAVDLGHHSHPLARFLAEAPVALAVPCTGFLWGIAPSHLPF
                     LPALRYGRTILSPARWRLAHNDLPTAQAPWPEWDQALTRWRRDVRLPERVHLTEADQRI
                     ALDLAESSHRAVLRAHLARDGTVLLHPASEAEDLGWTGGRAHEIVIPLVADQNRAPVRT
                     RGRPVGREHGHLPGCDNRVQLHLYGHRERQDPILTRHLSALLSELGSSRWWFVRYRDSG
                     DHLRLRLNCKPGALGAAFESLGEWARHLRRRGLITHASVETYLPETARFGGPTAIGAAE
                     RFFATDSAAVVAQLAAVGTVDAGALTSASMVDLATGLLGDSAAAMRWLIEHTRTSATAP
                     DRVVYRQAVDLVNNPPAVLGGRVATTWSARREALIAYRGALLATDTRPEDLLPDLLHLH
                     HARMHGPDLDEERRHLHLARAAALSWTARARRTP"
     aSDomain        10457..10726
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KSE_RS29110_Lanthipeptide_LanB_RRE.1"
                     /evalue="8.90E-24"
                     /identifier="RREFam001.1"
                     /label="KSE_RS29110"
                     /locus_tag="KSE_RS29110"
                     /protein_end="242"
                     /protein_start="152"
                     /score="75.0"
                     /tool="antismash"
                     /translation="TASTLAVERDGHVVIEHLPSGTAEVGPQHVHVRLTAPVRAALQGA
                     RAPIGWGYLAAQLADAFPSAPVIVIDKLISGMVEQRLLVTSLRPA"
     gene            12892..14139
                     /locus_tag="KSE_RS29115"
                     /old_locus_tag="KSE_58830"
     CDS             12892..14139
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138950.1"
                     /locus_tag="KSE_RS29115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58830"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_014138950.1"
                     /sec_met_domain="LANC_like (E-value: 7.2e-39, bitscore:
                     132.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTATAATTALTAADRLARALADPNTVWPLGHPDGGRSWPQSLA
                     GGAAGIALLHVERARTGYGDWDTAHTWLLAALDGDISAAANANLYFGAPALAFVTSLAA
                     AASSRYQRVLERLDTATATVTRSRLAAARHRIDRAQRPPMEEFDLIQGLSGLGAYHLSR
                     HPDHEITREVLAYLVRLTEPMPDPSGLPPWWMDVGPTGAPHPDYPGGHGNFGTAHGIGS
                     VLSILSRALLHGLAVPGTADAVERICSWTDRWRQDDETGPWWPGQLTVGQTVGGHLDPA
                     LHPRPSWCYGVSGTARAQQLAGLALGDPKRVNDAEKAILAALRDPRQLAELPDTGLCHG
                     TAGLLHAAWRMATTTGNRAIATELPYLADRLVTALGHDRLDPELLDGAAGAALALHTFG
                     TGLTPAPRWDTFLALA"
     gene            14156..14992
                     /locus_tag="KSE_RS29120"
                     /old_locus_tag="KSE_58840"
     CDS             14156..14992
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138951.1"
                     /locus_tag="KSE_RS29120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58840"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_014138951.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.3e-34, bitscore:
                     118.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHQLPWRQANIMFHDWEQAETTALAHLVPLLRAAEAEGTVAAWFV
                     IRKRPCWRLRYRPVSDGRDPVAQGLDRMTAARYITGWTQSVYEPEVHAFGGPEAMDSAH
                     RLFHRDSRGLTDYLAGQVGTHRRETSLLLCNLMLRSAGLDWYEQGDVWARVAAHRAQPA
                     GTAAGGHEQLQAAVRRLLSVDPHHALRPDGPLAGAAEWARAYADAGEETADLHAAGKLH
                     RGLRDVLAHHVIFAWNRIGLPYAVQAALTFAAKTVVFGPDPVTTSERSAASHVETP"
     gene            14976..16127
                     /locus_tag="KSE_RS29125"
                     /old_locus_tag="KSE_58850"
     CDS             14976..16127
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138952.1"
                     /locus_tag="KSE_RS29125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58850"
                     /product="hypothetical protein"
                     /protein_id="WP_014138952.1"
                     /transl_table=11
                     /translation="MWRLPDAAARRFPLVARPRPACLPLHQRIQALTRLADVAAEQGDP
                     SIASTVLNRAALIASDIGDDTAAGAMCHQHAAAYLHATPLPADAAIRALEPLVNLARLQ
                     LRAGRADQGRQYLLTLFDAVARAAPTDIEGIAVPADLVADTADRHTVRAWLWSVLLADG
                     TRALTTVGRWTEALAHVQTHHGIGRRMLDGRQTAVLAAATTGDRPAVLALLHDTEPGDP
                     WEDAVTAALTALCRPGDRRAAARAAGLWTVLEPGDGLAVFTTRLALTVLDATEPDTPAA
                     RNLARTAIIRTDESGDGYALRDLLAHPAARAVLAAERAEARERALAACALGSGTLPADS
                     RERLDAAVGGAVRVLENALAAPGERRPPAPRAPDPGIRQALKR"
     gene            16285..16899
                     /locus_tag="KSE_RS29130"
                     /old_locus_tag="KSE_58860"
     CDS             16285..16899
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138953.1"
                     /locus_tag="KSE_RS29130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58860"
                     /product="flavodoxin family protein"
                     /protein_id="WP_014138953.1"
                     /transl_table=11
                     /translation="MTNIAVIYYSSTGSTFRLAAAAAEAAEKAGAEVRLRRIAEIAPDA
                     AASRREGAEGFAAETADVPVAELADLEWADGILFGTPVHFGLAAPQLMHFINGTSKLSI
                     EGKLLNKAVSAFAAGSAAHGGQVSAILALHNALTHWGAPIVATGSTEPVLFKPNNGNPY
                     GASAVVGANPGVVADENLEAAAFQARRTLEVASVLKTLDGR"
     gene            16896..17732
                     /locus_tag="KSE_RS29135"
                     /old_locus_tag="KSE_58870"
     CDS             16896..17732
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138954.1"
                     /locus_tag="KSE_RS29135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58870"
                     /product="arylamine N-acetyltransferase"
                     /protein_id="WP_014138954.1"
                     /transl_table=11
                     /translation="MTAVLAAPAARLDEALVDAYLERIGAERPARPDLRALAELQERHV
                     LSVPFENLDYHLDREIHLDARVVDKIVRDGRGGACYEVNPAFGLLLEALGYRVRILAAR
                     VRRPDGLGAPLGHLLLRVDVDGVGHLVDVGFRRVSRRPLPLDTTAPQPDAEGVFAVTEP
                     FDGEQDLLLDGAPLYRVDLRERDLGQFRPSLWWFRTSPDSPFLHDLFCSLPTADGRVTL
                     KGTRLTLRTADGQRTVEELDGDEAVRDAYLTHFGIALARLPRIPVLPAGSSGIQVE"
     gene            17791..18264
                     /locus_tag="KSE_RS29140"
                     /old_locus_tag="KSE_58880"
     CDS             17791..18264
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138955.1"
                     /locus_tag="KSE_RS29140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58880"
                     /product="DUF4440 domain-containing protein"
                     /protein_id="WP_014138955.1"
                     /transl_table=11
                     /translation="MTTQTETGAETEAGAESAADAADRAALFAPVDDPADLPGRFMRAF
                     NARDLQAIDHLFEPGCVRVLTPGNVVSGDGRRAATSSFMALGIPMRLSVRHTYVYDDLA
                     LIIGDYLIEGTKPDGTHVLHQGTATDVCRRGADGHWRYAIDNPPGTDRAADGS"
     gene            18351..18998
                     /locus_tag="KSE_RS29145"
                     /old_locus_tag="KSE_58890"
     CDS             18351..18998
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138956.1"
                     /locus_tag="KSE_RS29145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58890"
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_014138956.1"
                     /transl_table=11
                     /translation="MTNVAIVYYSATGNIHKLAVAAAEAAEKAGAQVRLRRVAEIQEST
                     LAPNYTEWTAAYEEHVSGSREVEVATIDDLDWADAVVWGTPGRYGAMAGPLKHFIDQTF
                     ELHARHGLKNKAMSAFTSTGTPHGGQESTLLSLSNVFYHWGAIIVPPGVTDPILLAPSN
                     GNPYGVSATSGLQAIPGQLAQNVTEDNLKAVGYQTVRTLEIAAALKRGLDNG"
     gene            19209..20798
                     /locus_tag="KSE_RS29150"
                     /old_locus_tag="KSE_58900"
     CDS             19209..20798
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (36-428). E-value: 3e-49.
                     Score: 159.6. Matches aSDomain:
                     nrpspksdomains_KSE_RS29150_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138957.1"
                     /locus_tag="KSE_RS29150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58900"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_014138957.1"
                     /sec_met_domain="AMP-binding (E-value: 9.7e-49, bitscore:
                     164.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRIPKNKTILNLGLMAEEAAVRYGANTITLDEAMDALPEAGRRF
                     TVARFADLVAETANRLWAAGVRTRDHVVIHKTNSFDITLFACAAARIGAVPVMLSAHLD
                     GPTVEALLRRLKRPALLTDAAKLDGELAGAPLAELTSLVLSATGARPGATALADLAGAP
                     VRPAVVLDPDEPAMMTHTSGTTGIPKLVVHSSRSIGARYLWQDRVVRLLRKREAVLMHI
                     SYVHSRLYPGIGVLLKRNKPMVFLNDASPERLADALVEHRPGVLETHPNSFLECESILD
                     DPRRPISSVRFFNSTFDAIHPGTMHKFLQASERRSPVFLQVYGQSECGPLIARPYTRGN
                     VLHADGRCQGYPAPGITRYRLVPRNGQPATRETPGYIDVSTAGRALGYYGEEERFQQQV
                     HGEWWRGGDVGYRTKWGCLHLLDREVDVIPTIHSTLEVEDVLLHRLPELTELVIVPGRN
                     KEPLPVVCTRGDAPIDLDRWRAAVADQAAMADPVQLRLDELPRTATAKIKRLELASRLT
                     AAREPQPAGQLC"
     aSDomain        19317..20492
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KSE_RS29150_AMP-binding.1"
                     /evalue="3.00E-49"
                     /label="KSE_RS29150_AMP-binding.1"
                     /locus_tag="KSE_RS29150"
                     /protein_end="428"
                     /protein_start="36"
                     /score="159.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ALPEAGRRFTVARFADLVAETANRLWAAGVRTRDHVVIHKTNSFD
                     ITLFACAAARIGAVPVMLSAHLDGPTVEALLRRLKRPALLTDAAKLDGELAGAPLAELT
                     SLVLSATGARPGATALADLAGAPVRPAVVLDPDEPAMMTHTSGTTGIPKLVVHSSRSIG
                     ARYLWQDRVVRLLRKREAVLMHISYVHSRLYPGIGVLLKRNKPMVFLNDASPERLADAL
                     VEHRPGVLETHPNSFLECESILDDPRRPISSVRFFNSTFDAIHPGTMHKFLQASERRSP
                     VFLQVYGQSECGPLIARPYTRGNVLHADGRCQGYPAPGITRYRLVPRNGQPATRETPGY
                     IDVSTAGRALGYYGEEERFQQQVHGEWWRGGDVGYRTKWGCLHLLDREVDVI"
     CDS_motif       19734..19790
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KSE_RS29150_0001"
                     /evalue="3.90E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="KSE_RS29150"
                     /protein_end="194"
                     /protein_start="175"
                     /score="13.4"
                     /tool="antismash"
                     /translation="AMMTHTSGTTGIPKLVVHS"
     misc_feature    complement(20891..20904)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.74"
                     /tool="antismash"
     gene            20950..22422
                     /locus_tag="KSE_RS29155"
                     /old_locus_tag="KSE_58910"
     CDS             20950..22422
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138958.1"
                     /locus_tag="KSE_RS29155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58910"
                     /product="MFS transporter"
                     /protein_id="WP_014138958.1"
                     /transl_table=11
                     /translation="MSQLAENETARRRRLGLTLALLAFAQLIISIDYNIVYVALPEIGS
                     ALGFTAQNLQWVVSAYAVAFGGFLMLGGRACDLFGPRRMFVLGLSLYAGSSLLGALAQE
                     PGLLIASRAVQGIGGAFLFPATLTLVSTSFAEGKERNRAFAVWGTAGGSGMIVGSLLGG
                     VLTQAFGWSSVFYINVLLAGVAALLAFPLISPDATRKSGRGFDLAGALTSTIGITAVVF
                     ALGQGPVSGWGSLPVVGAFVAGAVLLALFFAIEKRSADPLLPLRLFANRNLTTATAVTF
                     AYMGTFGTLLYFLTVYFQGVHGYNALDTGLAFLVPMVAIAFGAQTAGRLATRYGIRAIM
                     IASLLIGVVGAGIVGVTMAADASYLVLVPGLIVLGVGQGAGYTLMFGAAAVGIEPQDQG
                     IASGAASTTQQVGGAVGLAVLVAVANSGLSGKTGEALRVATSDGTRNAFYLAAVGILIT
                     AVIALGLRKPEPRATTGSTADAAADTLEKAGV"
     gene            complement(22502..23836)
                     /locus_tag="KSE_RS29160"
                     /old_locus_tag="KSE_58920"
     CDS             complement(22502..23836)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138959.1"
                     /locus_tag="KSE_RS29160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58920"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_081539683.1"
                     /transl_table=11
                     /translation="MCTVGEPRLCRLGGPVPDSLWSTPKARSLAEQHRPGELVRLGRQH
                     RDWTLEALERRLGVSPSTVSRLERANRIVDLALLRQAAIEVGMPRHVLVTSLALGPSTG
                     HHTDRVAGSFRQAEESPMRRRTLVAAATVAGPAALLLGLDDALADTPGPTRNAAQLDQV
                     LNRARDLFDTGAHARLLEVLPGLIADAHAAADSRRDLDQARLSTVYSLATAVLIKTGHY
                     DRARLTADRARTWAEVSGSPLAQAAATREAAVVLRHQDRAPAAQRLMLTAVDRLENTGL
                     TTQPQTAAYAQLLCTLAYTAAVAGQRTEAVAMMAEARNAARRLPATPGTGSLFTITPAA
                     ADLYAVSVHWALGDAGAALEAGRNLRPEQFPTAERRARLHTDLARAWWQWGRPEQTANE
                     LLSALRASPAEIRDRSSIRAVVSDLVTRHPRAAGVRELAAAVPLS"
     misc_feature    complement(23420..23422)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23871..23885
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.27"
                     /tool="antismash"
     gene            23976..24431
                     /locus_tag="KSE_RS29165"
                     /old_locus_tag="KSE_58930"
     CDS             23976..24431
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138960.1"
                     /locus_tag="KSE_RS29165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_58930"
                     /product="hypothetical protein"
                     /protein_id="WP_014138960.1"
                     /transl_table=11
                     /translation="MATSTAPADQITGLFRNVRDHVPADLWDKQIGLLMRDHPYDSVMA
                     ARVLGQGYAYLLTAMAHRDEHLGLGPSSLVDIGVHTIVLDTVAYAELCRVHNGGRFLHH
                     VPAVEFKQDGTVPRTAQLIAAEGWEVDLPLWADAAGCSPCHPGNDSH"
     misc_feature    complement(24462..24471)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
ORIGIN
        1 ggtcgtagtc ggccaggtcc tggaggtggt ggaactccag ggacaggtcg agcaggtcgt
       61 agggctcccg gtgggcgcgg accagctcgc cgacggtgtg cagggccagc cggctgcggg
      121 agtcctccgc cgcgctgccg aggaccccga ggatcaccgc gccacccccg ccggctcggg
      181 caccgggacg gtcgccgccc cgcccgccgt tgcgtccgcc gccccgtccg ctgtggcgcc
      241 cgccgtcgcg ccgaccggtt cgatccggat ccggacggcc gactcggcca gcgtgaccag
      301 ctcgtccacc cgggccgccg agtcggcggc gaacacgtgg gtgctcaggc cggtgccgga
      361 gaagtccgag gcgggcagca gctcgccgac ccggcccgcc accgcgcggt gcacggccgc
      421 ggcggccacc gccgagtcgt cgaactcggc cagccgcccg tccgaggcgt agtggaccgt
      481 ccagcccgcg taggcgccga ccgggtcgcg gcgcagccgc cacggcgagt cgcccgcgtc
      541 gatcagcacc ttggcgtgcc gcaggtcgac gccccgggtg gcccggaacg ccgggacgat
      601 gccgccgccg cccggccgcg ccgcgacctc gcacagggtc aggccgtccg gctcgacgaa
      661 cgcctcgacg tgcagcacgc cggagcggat ccgccacgcc tcgaccacct gctcgaccag
      721 ccgcccggcg gcggcccgca ggaccgggtc gtccggggcg aggctggaca gcggcaggcc
      781 ccgggtgaac gcgagggtgt cgcgccggta caccgagacg tcccagagca ggctgccgtc
      841 gtgcaccacc gcgtccaggt ggcacatcgg ggcgtcgacg aacgcctccg ccaactgctg
      901 ccccggggtg aaccgttcgc gcagccagcg gtccagggcg gcctcgtccc ggcagaccgc
      961 gacgccctgc gaaccggaca gctcgcgcgg cttcagcacc accgcgccgt accgggccag
     1021 cagctcccgg gccagggccg gctcgtgcag caccccgccc ggggcgtgcc ggatgcccgc
     1081 cgcccgggcc acccgcttca tcagcgcctt gtcgcggacg ctgcgggtga agtcccggtc
     1141 gtcgcccgcc gcgccgtagc gggagcgcag ctcggcgacc gggccgagca gccgctcgga
     1201 gcccgccgag acccggtcca ccgggtgcac ggcgtggatc gcgtcggccg ccgagtccag
     1261 cgcggacagg tcgaacgggt cggcctggtg cgccaggtcg accggcgcgg ccagcaccgg
     1321 cggcgcgccg atcacactga cccggtaccg gtcggccggc agcaccgccg aaccgtcctc
     1381 gtcggtccag gcccggccgc ccgagcggtc caccagcagc acgtgggtgc gcgccagcga
     1441 ctcgtgccgc agcgccgtga acgactccac ccgggccgcg accgcccggc acgccgcggc
     1501 gtcggccccg gtcaccgcgt agcgcagcca gacggcggcg ccgtccagca cccggccggc
     1561 cgccggcggc gcgtccaccg aggccaccgc cggctcgtcg cgcagcgggc ccggctcggg
     1621 cgccgccacc acccggaacc gcccgggcgg cgcggccagc acccgcacca gcgcgctccc
     1681 cggccgcggc tccggccaga ccgtgcccag cccgagcgcc gccgtcgcgg ccagtgccag
     1741 caccggccgg gggaagaccg cgtccagcag cgcccgggcg tcctggtcca gaccgggcag
     1801 gacgcggtcc gcgccgtccg ggtagcgcac cagcccgcgc gccgggccgg tgcggcgggc
     1861 ggccgcctcg gcccgctcca gcagcccggc gggcagttcg gccgctgctg gcccggcccg
     1921 ccacagcagc gagcgcgagc cgtccggctc cgccgggagc tcctcgtaca cgcccaggtg
     1981 gcggaccgtc ccgccgtcca ggtacgacac cacccgcagg ccgggcgcgg tgccgggcgc
     2041 gctggcgggc gcggcctgcg gttccggggc gccggggagc gccgggcagc cctccaggag
     2101 ctcggcgagc cgggccgcgc ccggcgagca gccgagcacc gcgtcgaccg ggcggcgctc
     2161 gcgcagcgcg gccagggcgc ggtgcgcggc ggcctcgtcc ggggcgtcca gccactcacc
     2221 cgcgtagcgc cgctcccagc gcgcccggag cggcgccgcg tcggccgccg ggccggtcca
     2281 cagcacgctg agccggccgg tggcgccgcc gagcgcggcc agcacccgct ccggggccag
     2341 ctcggcggag ccctcggcgg ccgggtcgag caccagcagc aggtgcgggg cgccgtcggt
     2401 ccggtcgggg gacgcctggt cggcggtgtc ggcagtggcg tcccgctcga tctccacccg
     2461 gacggcggcg gccgcccggt cggcggcggc gcacgcctcc gcgacggtgc cgccgaccgc
     2521 cagcacgtgc ccgtaccggt cgtagttgca gtccagcgcg cgcacccggt cgcccggcgc
     2581 caccccgacc cgcagctcgg ccacctccgg ggcggcggcg ggcagcgcga ccgcgcgcac
     2641 cgtccccggg tacgggctcc acagctgccg cagggcgacc gcggccaccg gctcgtccac
     2701 ctccggcacc ggccggccgg ccgccagcgc ggccaggtcg gcggtgacgc tgcggccgag
     2761 ggcgagctcc agctgccggg tcaccgcgtg gccggcgatc cggccgttga cctccagcag
     2821 ctccgggccg gtcggggtga ccagcagctc gatgtgcatc ggactgttcc gcacccccag
     2881 cgcctccacc acctcccgga cgaactcccg tgccgcgccc cgttgttcga actcggcggg
     2941 gaagtggccg cccagctccg cggtcgtccc ggggcgggac ggcagccgct cggagaagcc
     3001 gtagaagagg atccggccgt cctgcaccag cagttcggcg ctgatgtgcc ggccgaaccg
     3061 gaactcctcc agcagcacct gatcgggacc cggggcgaac gcggcgggcg cggccgccgg
     3121 gggcgcgaac gccgcgcgca gcgcccgctc cacctgctcc ggacgccacg ccacggtgac
     3181 gccctgcgag gcccagcccg cgttcggctt caccaccagc gggtagccga gaccggccgc
     3241 tgcggccagc ccctcggcgg ccgaaccggc cgtccgccag cgcagcgtgc ccagcccggc
     3301 cgcgtccagc cgggcccgga cggcggcctt gtcgcgcatc agcagcacgg tctccagcga
     3361 ctccccgggc acgcccaggt cacgggccag cgcggcggcg gtcggcatgc agtgctcggt
     3421 gacgcagacg accccgtcca ccgggttcgg gccgagccgg tcacgcaccg acccggccag
     3481 gtcgaggacg tcccgggtgg acggcacctc gatgatccgg gcggcccggt gccggttctc
     3541 gaagccgggc accccggcgt agacccggag gtcctcgacg atcacgctga cctcggcccc
     3601 ggcgtccacc aggtcgtcca cgaagccgaa gccgcgggtg agggcaacct ccagcatgac
     3661 gatgtgcatg gtcaatcctt cagggagggc ggtaggtccc gaatcttccg cacccggacc
     3721 acgccgccca gcacggcgcc cacaccacgt caggtcccct cccggcggcc gggcggcggg
     3781 agggcggcgg gagggcggcg gccgcccgag gtgacggact ggccgccggg cgctgtccgc
     3841 cgccccgccc gcccgacgac agtggggacc ccgtggcgcg cccgccggcg cggcccgaac
     3901 aacccgagaa aggtggggga ccgcatgtcc accgaacccc tgcgcgtggc cgtcatcatc
     3961 gcgagcgtcc gcaagggacg ctccggcccg accatcgcca actggttcac cggcgtcgcc
     4021 ggccggcgcg ggagcctggc cgtcgacctg gtcgacctcg ccgactacga cctccccaac
     4081 agcctcaccg accagcccga ccaggaactc gccgccaagc tcgccgacat cggcggccga
     4141 ctcgaccggg ccgaagcctt cgtcgtcgtc acccccgagt acaaccactc cttcccggcc
     4201 tcgctcaagg ccctgatcga ctggcacacc acccagtggc aggccaagcc ggtcggcttc
     4261 gtcggctacg gcggcctggc cggcggccag cgcgccatcg agcacctccg gcagatcttc
     4321 gccgagtgcc acatggtcag cgtccgcgac gccgtcggat tccacagcca ctggggcctg
     4381 ttcgacaacg agggcaacct gatcgacccc acccaccacg aatccgccgc caagtcgctg
     4441 ctcgacggcc tggagtggtg gggcaccgcg ctgcgggaca agaaggcaca gcagccctac
     4501 ggctcctgac cctgatgccg accactcgcc gcacgggcgc cggcgtgggt gcggggacgg
     4561 gcacgggcac ggttgccggc cggaccaccg cccgcaccgc agcccgcccc gccaccgccc
     4621 gtcccgccgc tgggcgttcc cgctccgccg ggccgcccgt cgcggggctg gtggcggcgc
     4681 tggcgctggt cggcacgctg gtggtggggc agctctacgc gacgatcccg ctgctgccgc
     4741 ggctcggtgc cgcctggggg gtccccggct ccaccgcgac ctgggcgacc agcgccttcg
     4801 ccgccccgta cgcggtcgtc tcgctgctca gcgggcaact ggcccgccgg tacggcacgc
     4861 gggcggtggc ggtgaccggc gtcgtggtgc tggcgctggc caccgcgtgc gtcccgttcg
     4921 gcggcggcct cgccgccgga ctcgcgctgc gggccgtgca gggcgcgggc gcgggcgtct
     4981 acgtgccgat ggcgtacgcc tgcctgaacg cccgggtcgc gcccgcccgg ctgccgttcg
     5041 cgctcaccgt cgtctcggcc tgcatggccg gcaccgtcgt caccggccag ctcgaatccc
     5101 agctgctcgc ctcgctgctg ggctggcgcg gggtgttcct ggcctgggcg ccgctgctgc
     5161 tgctcggcgc cgccgtcctg caccggacgc tgcccgccga ccgccccgga cgctccgcgg
     5221 ccgtccccgc ggcccggccc gcgatccggc cggtccggct gctgccgctc tacctggccg
     5281 cgctgctctg ctccaccggc atgaccgccg tctacaccgg cctgcaactg tacgggccgc
     5341 ccgcactcgt ccgggacgac caggcgatgc tcgccctgcg cgccaccgcc ctgcccgccc
     5401 tgctcaccgc cgtcctgctc gccccgctgc tcggccgcgt ccccgccccc cgccgggcca
     5461 ccgccggctt cgccctcgcg gccctcggcg ccctcggcac cgccgcgacc ggccggcaca
     5521 ccggcgggct cgccctcgcc ctcgccgtct tcatgctggg cgtcgccacc gtcggcccgg
     5581 ccctggtcca gcacctcggc gcccgcacca ccggcacccc gaacgccccg accgcgatgg
     5641 ccctctacgg cttcaccctc aacatcggcg gcgccctcgg cgcccaactc cccaaagcca
     5701 ccgccaccac caccggcctc ggctgcctcc tcgccaccct cctcaccacc tgcgcggccc
     5761 tcctcgccac ccaccgcacc ccaccctgac ccccgcccgc cacccgggcc cgggggcccc
     5821 ggcgggtgcg ggcggtggtg tccggcgctg tccggtacct gctctggccg taccgactgt
     5881 caggtggtcg ccgtggtcag gggtcaggcc gctatgacgg cccgcaggtg ccgcagagag
     5941 gcttcggcgc cgtcccgaac gtcggggagg gtgctgccgg cgcgcaggat ccgctggagc
     6001 tggtgcggca gccggttccg gcggcgcgag ccagcaggat gacggcttcg gcgcgggcga
     6061 cgggtgtgtg gcgaggtcgc gggtgtgcag gccggacttg cgcagttcgt tgccgtggcg
     6121 gcgcagggcg ccctgtcagc tcgcctcgtg ccccggcgaa ttcgacgccc gcggcatccc
     6181 ctcacctccg cccactgcca ggcccgtcgc ggccggctct tgctcaacgt tctccaccag
     6241 gtcttcgccc gctgccgctg cgcgcacgag tgggacgact tcgacaccgc catgcgcgca
     6301 ctcgccttcg acggcctgct ctcgggtatc acgtgggatt gacaactggg aggccccggg
     6361 ccggcctcgg tgtcaccccg aggccggcgc gcgttcgacc gcgtccgggc agatcagagt
     6421 tcgccggcga ggatgcctgc cttggcggct tcccactcgc gggcggtgaa gcacagcggc
     6481 gtgcggtcgg ggttcttgga gtcgcggatg gctcggcccc caccgggcag gtcggtgacc
     6541 tcaaggcact cgccctctcc tccgctggcg gaggacttgc gccagacggc gccgctgagg
     6601 tcgtaggcgt agaggtcggc cttcggtgcg ttcacttgcg ggttccttct tccatgcgtg
     6661 cgatcagtgc tagcgaatcc tccggcggca gggcagcagc ctggatccgt tcgaaggccg
     6721 cagcgtggag cttcacgccg tcggcgtcct caacgtagga cgatccgagc aggttctcca
     6781 actgcacgac gtcgggcagc ggcccgggga acccgatcaa gttgaatccg ccgatggtgc
     6841 ccgggtgcag ggtggcctcc agcggcatga cctggatcgt cacgttgggc agttcggccg
     6901 cgtcgagcag tcgctgcagt tgctcgcgca tgatggccgg tcgcaccgcg aaacgctggt
     6961 gaaggactgc ttcggggatg atcgcccaca gctccagcgg tgggcggccg gtgcggctga
     7021 ggacagcctg ccgggcctgt cggacctcgg ccagggcggt gacttcctcg ggggtgcggg
     7081 tcatcgcgat cgccgcgatg gtctcgcgcg cgtaggccgc gctctgcaga agcccgggaa
     7141 tcagtcctgg tgagtagatg cggatgctct ccgcgtcggt ctccagcgag atgtagtccg
     7201 cgtaggccgg tgacagcaca ccgccgtagg tctgccacca gcctcgtttg ccggcgtcct
     7261 tggcgaggct gtccagggcg gtggacacct cggggtcgct gacgccgtag accgtcagca
     7321 ggccggcgag ctcggcgggg cggagggact gggtggcgtt ctcgatcttc gagagcttcg
     7381 gccccttcca gcccatggtc tcggccgcac cgtcgagcgt cagcccggcc gtgttgcgca
     7441 gacccctcaa ggctttgccg agctgacggc gccggacggt gggaaccagc ggagagttgg
     7501 acatgcgcag agtgtcgcac tgcccatacg agcaaggcga gccctctcgt tcgaacgctc
     7561 gacccacttg ggtagaaacc ttgcgcccaa ctcaagaagg gtccatgctc tgagggcagg
     7621 cgctaactga tcgtcaatcg acgtcagctg agcgttactt gttccgatgc tgcgcggacg
     7681 ctagcccgca gatagggagg ggccgtggac gcggcagccg acgaactgtt gcagagcgaa
     7741 cccgggttct acgtccagga cggcgcggcg ggtgtgatcg tccacctggt cgccgaccgg
     7801 gggagcctgg cgaggatgcg gcggctggcg gtgttcaggt tgggcaaggc cggcatcggc
     7861 ctcgacctgg cccaggatgc ggagctgctg gtgagcgagc tggtggggaa cgcggtgcgg
     7921 gcgtgcgggg acggagtgcc gctggtcgtc gaggttgcca cgggtacgga cggggtgagg
     7981 gtgaggggcc atgacccgga gccgggtgaa ctgccgcgac gttgtggcac cacggctggc
     8041 gatcggcagg ccgagggcgg tcggggggct gctgctcgct tcggcacttg cgccgggctg
     8101 ggaggtcgcc ttgacgccgg tcggtaagta ggtcaggtgt ctgctgcccc accggccgcc
     8161 ccgaggccgc tccgggtccg gggcgcgccc ggccgcgtga acgccaactg tccaacgcgc
     8221 cagacgaggt gggagcggaa ggagtgaccg aggacatcat gcccaccgac cacgttcggc
     8281 gcggggtgac cccgacggac ccgcagtcga accccgaagc ccgcccccac tgcggcgcgt
     8341 acctacccgc acggcatgga gctctggctg gcgtcctgct gggcgccgga ccgagtcggg
     8401 ccgccgaaag cgccaacttc ccgacagaaa caggtaatcg gatgacttcc atcgacgact
     8461 cgttggtccg cgatcccggc gtgctgcgct cggacatggt ccgtgcgctg cgcgagcagg
     8521 acgggatcag gtccgagccg gtcgccgccg ccttcgcggc ggtgccccgc caccggttcg
     8581 caccggaggc gcctctggag ctcgtctacg atccgcaccg cacggtgccg gtcaagaagg
     8641 acgagaacgg cctggagctc agcgtcatgt ctgccgctca tctgcaggcc gtgatgctgg
     8701 agcaggccgg agtcgagccc ggcatgaagg tattggagat cggttccggc ggcgtcaacg
     8761 ccgcctatct ccaggaactc gtcggcaagg cgggcgaggt caccaccgtc gacatcgact
     8821 gcgatgtcat cgaccgggcc cgacgatgcc tggacgatgc gggatacccc caggtgcgga
     8881 cggtcctggc cgacggtgag agcggcgtgc ccgacggctc tccgtacgac ctgatcaccg
     8941 tcacggccgc cgcgtgggac atccccccgt cgtggatcag cggtctggcg ccgtccggcc
     9001 gtctcgtcgt gccgctgaca gtctgtggca cgacccgctc gatcgccttc gaccgtgacc
     9061 gcggccccga gagcgacgac gagggtctgg tcagccgttc ctacagcctg gcccggttcg
     9121 tgcccatgca gggagaaggg gcggcggaag aacgccgggt actgctccgc gagggtgtgg
     9181 ccgtacagac cgacgacgtg cgggtaccgc tcgacgccca ggcgctgaac cgcgcgctcg
     9241 acgggcccag gctggagtgc tggtccgggg ccgcgtacga cctgcccgac gagttggagc
     9301 tgtacctgac gttcaacctg tcgagcccgg cccgcctgca cgccgccaac gacgtggtgg
     9361 agcgcggcct cgtggaggcg tccgcgctgt tcggggtgcc cgtcctggtg agcgaggaca
     9421 gcttcgccta ccgcacccgc cgcgagaacg cggacaccgg cggcttcgag agcggcgtgg
     9481 tcgcccacgg gcccggtgcc caggcgctcg ccgacgagta cgccacgctg cttcgccgct
     9541 gggcccgtga ccaccgtcgt cggggtgccg cgacgttccg ctacctgccg ggccccgtgc
     9601 ccgttcccct gccccggaac gccgtccggc gacgccacgg catcgtcacg gcgacctggc
     9661 gctgagactc ccgggccccg acctggggtc cgggccgtgc accatcaacc gatctgcccc
     9721 aaggaggcat gcatgaccgt gcagttggag ggccccatcg cgtccgcgcg gccggccgac
     9781 gagcagtacg acctggccga cttcgagctg gacatcacca tcgtcgaggg cggtcccgcc
     9841 gcggaccagc tcatccgcct gacgaacgac ggctgcaact ccacgtgcgc caccgcgtgc
     9901 gtgagctgcc cgtagccggt cggagcgcgt tcatcacggt gcccggccgc gcccagccca
     9961 tgggcgcggc cgggcaccgc tcggcagaga aggggggctc atgtaccgcc acatcgacgc
    10021 ggcactggtt cgggctgctg cctggaacct cgaccaccag acgtcctggc cggacctcgt
    10081 cagcgagcga gcagacccgg aatcgtggcg agcatggctg caacaggctt ggcagaaaca
    10141 ggacttcgca ggtgccgtta cggtcgccag ccccgatctc gcgagccggg tggaacagat
    10201 ccgcaccggt cgaccgatcc agagcgctga cgttcggcgt acggtgctcg cggttctgcg
    10261 ctacctgctg cgagcccgca cccgcgccac tccgttcggc ctgttcgccg gtgtcgcccc
    10321 cgcgcgcatc ggtgccacgg ccacgctgcg cgtgggcaac gagcaccatg ccacctccag
    10381 gaccgacgcg gcgtccagca cggcgctgat cgatcggttc gagcagcacc cggcgctgcg
    10441 gacccacctg gtgctgaccg cctccaccct cgcggtggag cgtgacggac acgtggtgat
    10501 cgagcacctc ccgagcggaa ccgccgaggt gggaccgcaa cacgtgcacg tgcgcctgac
    10561 cgctcccgtc cgcgcggcgc tccagggcgc gcgagcaccg atcgggtggg gttacctcgc
    10621 tgcgcaactg gccgacgcct tcccgagcgc accggtcatc gtgatcgaca agctcatctc
    10681 gggcatggtc gagcagcggc tcctggtcac cagcctgcgc cccgcgatga cggtcaccga
    10741 cccgctcgcc gccctccacg gccacctgtc acatctcccg cccgtcgatg cggacgagat
    10801 acgtcggacg cccaggaaca tggtcgacct gcgggtggac tggaagttga ccgtccccga
    10861 ggtagtggcc accgaggcgg ccgcggcggc gcgggcgctt acccggctgg ctccccgagc
    10921 tgccctgacc ggctgggccg aatggcacgg ccggttcctg gagcggtacg ggccgcaggc
    10981 gaccgtgccc gttctggaag ccgtcgacgc gctcggatac ccgtccggct tcctcggtgc
    11041 caccaccgcg ccgacgacct ccccgctgcc cgagcgcgac ggtcggctca tcaggctcgc
    11101 ccacagcgca ggcatgcagc gccgcctgga agtcgagctc gacgacgccg cgttggagga
    11161 actggccgcc acccaccccg gccacccggt gcagccgagc accgaactga cggttcgcat
    11221 ccacgcaacc agcctccccg ccctccaagg aggcgagttc acgctgcacg tcgtcggtgt
    11281 ggcgcgttcg gccggtgcca ctgcgggccg tttcctggac ctgctggggg acaccgaccg
    11341 cgaccgcatg accaaggcgt acgccgagct gccggcagtg caccggggcg cactcctcgc
    11401 acagatcagt tcgccaccgc tgtccactcg cgccgggaac gttgcccgag ccccacaggc
    11461 agccgatctg gtcatctcgc tcggagagca ccacagccag gacaccggcc tggttcccgt
    11521 gacggacctg gcggtcaccg ccgatgccga acagctgcac ttggtctcgc tctcccgtga
    11581 ccgccccctg cacaccctgc tcctcaacgc cgtggacctg ggccaccact cccatccact
    11641 ggcccgcttc ctggccgagg cacccgtcgc gctggccgtc ccctgcaccg ggttcctgtg
    11701 gggcatcgcc ccctcccatc tgccgttcct accggctctg cgctacgggc ggacgatcct
    11761 gtccccggcc cgctggcgcc tcgcccacaa cgacctgcct actgcccaag caccatggcc
    11821 cgagtgggac caggccctga cccggtggcg ccgtgacgta cgcctgcccg aacgggtcca
    11881 cctgaccgaa gccgaccagc gcatcgcctt ggacctcgcc gagtcctcgc accgggctgt
    11941 gttgcgcgca cacctggcgc gcgacggcac agtgctgctg caccccgctt ccgaagccga
    12001 ggacctgggt tggaccggcg ggcgggcaca cgagatcgtc atccccctgg tcgctgacca
    12061 gaacagggcg ccggtccgaa cgcgaggccg gcccgtgggc cgggagcacg ggcacctgcc
    12121 cggatgcgac aaccgcgtcc aactccacct gtacgggcac cgcgagcggc aggacccgat
    12181 cctgacgcgg cacctgtcgg ccctgttgag cgaactgggc tcctcccgct ggtggttcgt
    12241 ccggtaccgc gattccggcg accacctccg cctccggctg aactgcaagc ccggggcgct
    12301 cggcgccgct ttcgagtccc tcggagagtg ggcccggcac ctgcgccgcc gtggcctgat
    12361 cacccacgcc agtgtggaga cctacctccc ggagaccgcg cggttcggcg gccccaccgc
    12421 gatcggggcg gccgagaggt tcttcgccac cgactccgct gccgtcgtgg cccaactcgc
    12481 cgccgtcggc acggttgacg cgggtgccct gacctccgcg agcatggtcg acctcgccac
    12541 cggcctgctc ggcgacagcg ccgcggcgat gcgatggctc atcgaacaca cccgcaccag
    12601 cgccactgcc cccgaccgtg tcgtctaccg ccaagcggtc gacctggtga acaacccgcc
    12661 ggccgtcctg ggcgggcggg tcgccaccac ctggtccgcg cgacgcgaag cactgatcgc
    12721 ctaccggggc gcgctcctgg ccacggacac acgccccgag gacctgctgc cagacctgtt
    12781 gcacctccac cacgcccgga tgcacgggcc cgacctggac gaggagcgga gacacctgca
    12841 cctggccagg gcagccgcct tgagctggac ggcacgagca cggaggacac cgtgaccacc
    12901 acagccacgg ctgccaccac cgcgctgacc gcagccgacc ggctcgcccg ggcactggcc
    12961 gacccgaaca ccgtatggcc actcggccac cccgacggcg gccgttcctg gccgcagtcg
    13021 ctggcaggag gagccgcggg catcgccctg ctgcacgtcg agcgcgcccg caccggctac
    13081 ggggactggg acaccgcgca cacctggctc ctcgccgccc tggacgggga catcagcgcg
    13141 gcagccaacg ccaacctgta cttcggcgcg ccggcgctcg ctttcgtcac gtccctcgcg
    13201 gcggccgcgt cgagccgcta ccagcgcgtc ctggaacgcc tggacaccgc gaccgccacg
    13261 gtcacccgca gccgcctggc cgccgcccgc caccgcatcg accgcgccca gcggcccccc
    13321 atggaagagt tcgacctgat ccagggcctg tccggactgg gcgcctacca cctgagccgc
    13381 caccccgacc acgagatcac ccgggaggtg ctcgcctacc tcgtccgcct gaccgagccg
    13441 atgcccgacc cgagcgggct gccgccctgg tggatggacg tcggaccgac cggcgcaccc
    13501 caccccgact accccggcgg ccacggcaac ttcggcaccg cccacggcat cggctccgtc
    13561 ctgtccatcc tgtccagggc cctgctccac ggcctggccg tgcccggcac ggccgacgcg
    13621 gtcgagcgga tctgctcctg gaccgaccgc tggcgccagg acgacgagac gggcccttgg
    13681 tggccgggcc agctcaccgt cggacagacg gtcggcgggc acctcgatcc ggccctgcac
    13741 ccccgaccgt cctggtgcta cggcgtcagc ggaaccgccc gtgcccagca gttggccgga
    13801 ctcgcactcg gcgatccgaa gcgggtgaac gatgccgaga aggcgatcct cgcggccctg
    13861 cgcgacccgc ggcaactggc cgagctcccc gataccggcc tgtgccacgg cacggccggc
    13921 ctgctgcatg ccgcatggcg gatggccacc accaccggaa accgcgcgat cgcgacggaa
    13981 ctgccctacc tggccgaccg attggtcacc gcgctcggcc acgaccgtct cgacccggaa
    14041 ctgctcgatg gagccgccgg ggcggcgctc gccctgcaca ccttcggcac ggggctcacg
    14101 cccgcaccgc gctgggacac cttcctcgct ctggcatgaa ccccggaggc ccacgatgca
    14161 ccaactcccc tggcgccaag ccaacatcat gttccacgac tgggagcaag ccgagaccac
    14221 cgccttggcc cacctcgtcc cgcttcttcg tgccgccgag gccgaaggca ccgtcgccgc
    14281 gtggttcgtc atccgcaaga gaccctgctg gcgcttgcgc taccggcctg tctccgacgg
    14341 gcgtgacccc gtcgcgcaag ggctcgaccg gatgacggcc gcccggtaca tcacgggctg
    14401 gacgcagagc gtctacgagc ccgaggtcca cgccttcggc ggccccgaag ccatggacag
    14461 cgctcaccgg ctcttccacc gcgacagtcg cggcctcacc gactacctgg cgggccaggt
    14521 cggcacccac cgccgcgaga cctccctgct cctgtgcaac ctcatgctgc gatcagccgg
    14581 gctggactgg tacgagcagg gcgacgtgtg ggcccgagtc gccgcccacc gcgcccagcc
    14641 cgccggcacc gcagcaggcg gccacgagca gctgcaggcc gccgtccgcc gcctgctctc
    14701 ggtggacccg caccacgctc tgcgaccgga cggcccgctc gccggtgccg ccgagtgggc
    14761 ccgcgcctac gccgacgccg gggaggagac ggccgacctc cacgccgcgg ggaagctcca
    14821 ccgcggcctg cgcgacgtcc tggcgcacca cgtgatcttc gcctggaacc ggatcggcct
    14881 gccgtacgcc gtccaggccg cgctcacctt cgccgccaag accgtcgtct tcggcccgga
    14941 ccccgtcacc acgtccgaga ggagtgcggc cagccatgtg gagactccct gacgccgccg
    15001 cccggcgctt ccccctcgtc gcccggccgc gaccggcttg cctccccctg caccaacgca
    15061 tccaggcgct gacccgactc gcggacgtcg cggccgagca gggcgacccg agcatcgcct
    15121 cgaccgtcct caaccgcgct gccctgatcg cctccgacat cggcgacgac accgccgccg
    15181 gcgcgatgtg ccaccagcac gccgccgcct acctgcacgc caccccgctg cctgccgacg
    15241 ctgcgatccg cgccctcgaa cccctcgtca acctcgctcg cctccaactc cgcgccggcc
    15301 gggcagatca aggccgccag tacctcctga cgctgttcga cgccgtcgcc agggccgccc
    15361 ccaccgacat cgagggcatc gccgtccccg cagacctcgt cgcagacacg gccgaccgcc
    15421 acaccgtccg cgcctggctg tggtccgtcc tgctcgcgga cggcacccgc gccttgacca
    15481 ccgtcggccg ttggacggag gcactcgccc acgtccagac gcaccacggc atcggccggc
    15541 gcatgctcga cggccgccag accgccgtcc tcgccgccgc caccaccggc gaccgccccg
    15601 ccgtcctcgc cctcctccac gacaccgaac ccggcgaccc gtgggaggac gccgtcaccg
    15661 ccgccctcac cgccctgtgc cgccccggcg accggcgcgc cgccgcgcgc gccgccggcc
    15721 tgtggaccgt cctcgaaccg ggcgacggcc tcgccgtgtt caccacccgc ctcgcgctca
    15781 ccgtcctcga cgccaccgaa cccgacacac ccgccgcccg gaacctcgcc cggaccgcca
    15841 tcatccgaac ggatgaatcc ggcgacggct acgccctgcg cgacctcctc gcccaccccg
    15901 ccgcccgcgc cgtcctggcc gccgagcgag ccgaagcccg cgaacgggcc ctcgccgcct
    15961 gcgcgctggg cagcggcacc ctccccgcgg actcccggga gcggctggac gccgcggtcg
    16021 gcggcgccgt ccgggtactc gaaaacgcac tcgccgcccc gggcgagcgg cgcccgcccg
    16081 ctcctcgggc accggatccg ggcatccggc aggccctgaa gcgctgagac ctgccaccgc
    16141 gcacggcaga gccggagccg ccgtggacct gacggactgt ccggtcgggg ctcgggccgg
    16201 gcgggggcgt ggcgggagga tcgttctcgg cccccgggag cagggagtgg gccggagacg
    16261 accagccagg gagcgcagca cgccatgacg aacatcgcgg tcatctacta ctcgtccacc
    16321 ggttcgacgt tccggctggc ggccgcggcc gccgaggcgg cggagaaggc gggcgcggag
    16381 gtccggctgc gccggatcgc ggagatagcg ccggacgcgg ccgcctcccg gcgggagggt
    16441 gccgaggggt tcgcggcgga gaccgcggac gtgccggtgg ccgagctggc ggacctggag
    16501 tgggcggacg gcatcctgtt cgggacgccg gtgcacttcg ggctggccgc gccgcagttg
    16561 atgcacttca tcaacgggac gtcgaagctc tcgatcgagg gcaagctgct gaacaaggcg
    16621 gtctcggcgt tcgcggccgg ttcggcggcg cacggcggcc aggtgtcggc gatcctggcg
    16681 ctgcacaacg cgctgaccca ctggggcgcg ccgatcgtcg cgacgggttc gaccgagccg
    16741 gtgctgttca agccgaacaa cggcaacccg tacggcgcgt cggcggtggt cggcgcgaac
    16801 ccgggcgtgg tggcggacga gaacctggag gccgcggcct tccaggcccg ccggaccctc
    16861 gaggtcgcgt cggtgctgaa gaccctggac ggccggtgac cgccgtgctc gcggcccccg
    16921 ccgcccgcct ggacgaggcc ctggtcgacg cgtacctgga gcggatcggc gccgagcgcc
    16981 cggcccggcc ggacctgcgc gcgctggccg agctgcagga acggcacgtg ctgtcggtcc
    17041 cgttcgagaa cctggactac cacctcgacc gggagatcca cctggacgcc cgggtcgtcg
    17101 acaagatcgt ccgggacggc cggggcggcg cctgctacga ggtgaacccg gcgttcggcc
    17161 tgctgctgga ggcgctcggc taccgggtcc ggatcctcgc cgcccgggtc cgccgcccgg
    17221 acggcctggg cgcgccgctg gggcacctgc tgctccgggt ggacgtcgac ggcgtcggtc
    17281 acctggtgga cgtcggcttc cgccgggtca gccgccggcc gctgccgctg gacaccaccg
    17341 cgccgcagcc cgacgccgag ggcgtcttcg ccgtcaccga accgttcgac ggcgaacagg
    17401 acctgctgct ggacggcgcc ccgctctacc gggtcgacct gcgcgagcgc gacctgggcc
    17461 agttccggcc ctcgctctgg tggttccgca cctcgccgga ctcaccgttc ctgcacgacc
    17521 tgttctgctc gctgcccacc gccgacgggc gggtgaccct caagggcacc cggctgaccc
    17581 tgcggacggc cgacgggcag cgtacggtcg aggagttgga cggcgacgag gcggtacggg
    17641 acgcctacct gacccacttc gggatcgcgc tcgcgcggct cccgaggatc cccgtgctcc
    17701 cggccggctc gtccggcatc caggtcgagt gagcgccgag caagcccagg tcgagcaact
    17761 gcccacccgc aagcccgccg aggagttccg atgacgaccc agaccgagac cggggccgag
    17821 accgaggccg gggccgagag cgcggcggac gccgccgacc gggccgcgct cttcgccccg
    17881 gtcgacgacc ccgccgacct gcccggacgc ttcatgcgcg cgttcaacgc ccgtgacctg
    17941 caggcgatcg accacctctt cgagcccggc tgcgtccgcg tcctgacccc cgggaacgtg
    18001 gtgtccggcg acggccgccg ggccgcgacc agcagtttca tggcgctcgg catcccgatg
    18061 cggctgagcg tccggcacac ctacgtgtac gacgacctgg ccctgatcat cggcgactac
    18121 ctgatcgagg gaaccaagcc ggacggcacg cacgtgctcc accagggcac cgccaccgac
    18181 gtctgccgcc gcggcgcgga cggccactgg cgctacgcga tcgacaaccc gcccggcacc
    18241 gaccgcgccg ccgacggctc ctgacgtccg cgcctcccgt acgaagaacc gcagccactc
    18301 gccgcgcggc agcacagtcg cggcggcgga gaagagagag ctctcacccc atgaccaacg
    18361 tagcgatcgt ctactactcg gcgaccggga acatccacaa gctcgcggtc gccgccgccg
    18421 aggccgccga gaaggccggc gcccaggtcc ggctgcgccg cgtcgccgag atccaggaga
    18481 gcaccctggc cccgaactac accgagtgga ccgccgccta cgaggagcac gtctcgggca
    18541 gccgcgaggt cgaggtcgcc accatcgacg acctggactg ggcggacgcc gtcgtctggg
    18601 gcaccccggg ccgctacggc gcgatggccg gcccgctcaa gcacttcatc gaccagacct
    18661 tcgaactgca cgcccggcac ggcctgaaga acaaggcgat gtccgccttc acctccaccg
    18721 gcaccccgca cggcggccag gagtcgaccc tgctgtcgct ctccaacgtc ttctaccact
    18781 ggggcgcgat catcgtgccg cccggcgtca ccgacccgat cctgctcgcc cccagcaacg
    18841 gcaacccgta cggcgtgagc gccacctccg gcctgcaggc gatccccggc cagctggcgc
    18901 agaacgtcac cgaggacaac ctgaaggcgg tcggctacca gaccgtccgc accctggaga
    18961 tcgccgcggc cctgaagcga ggtctcgaca acggctgacc ccgtattccc cccccgagca
    19021 acacgcacat ccggcgcatc cacaggtccg ccgcggctcc ggccgcggcg gacctgtcgc
    19081 gttcggccgg cctctcgacg gcaaggatcg gcgcaggtca gcggcggtca gtgggggtca
    19141 actcgctgat gtgacacagt caatcggccg tcctgtcggc ctgcggccgc ctctgcgagc
    19201 gtggaagcat gctccggatc cccaagaaca agacaatcct gaatctcggc ctgatggccg
    19261 aggaggctgc tgttcgatac ggcgccaaca ccatcaccct cgacgaggcc atggacgccc
    19321 tgccggaggc ggggcgccgg ttcaccgtgg cccggttcgc cgacctggtc gccgagaccg
    19381 ccaaccggct gtgggcggcg ggcgtccgca cccgcgacca cgtcgtcatc cacaagacca
    19441 acagcttcga catcacgctg ttcgcctgcg ccgccgcccg gatcggcgcc gtgcccgtga
    19501 tgctctccgc gcacctcgac ggcccgaccg tcgaagcgct gctgcggcgg ctcaagcgcc
    19561 cggcgctgct caccgacgcc gccaagctcg acggcgagct ggccggcgcg ccgctggccg
    19621 aactcacctc gctggtgctc tccgcgaccg gtgcgcggcc cggcgcgacc gcgctcgccg
    19681 acctggccgg cgccccggtc cgcccggccg tcgtgctcga cccggacgag cccgcgatga
    19741 tgacccacac ctccggcacc accggcatcc ccaagctggt cgtccactcg tcccgctcga
    19801 tcggcgcccg ctacctctgg caggaccggg tggtgcggct gctgcgcaag cgcgaggccg
    19861 tgctgatgca catctcgtac gtgcactccc ggctgtaccc cgggatcggc gtgctgctga
    19921 agcgcaacaa gccgatggtg ttcctgaacg acgcctcccc ggagcggctg gccgacgcgc
    19981 tggtcgagca ccgccccggc gtcctggaga cccacccgaa ctcgttcctg gagtgcgagt
    20041 ccatcctcga cgacccgcgc aggccgatct ccagcgtccg cttcttcaac agcaccttcg
    20101 acgccatcca ccccggcacc atgcacaagt tcctccaggc gtccgagcgc cgcagcccgg
    20161 tcttcctcca ggtgtacggc cagagcgagt gcggtccgct gatcgcccgc ccctacaccc
    20221 gcggcaacgt cctgcacgcc gacggccgct gccagggcta cccggccccc ggcatcaccc
    20281 gctaccgcct ggtcccgcgc aacgggcagc cggccacccg cgagaccccc ggctacatcg
    20341 acgtctccac cgccggccgc gccctcggct actacggcga ggaggagcgc ttccagcagc
    20401 aggtgcacgg cgagtggtgg cgcggcggcg acgtcggcta ccgcaccaag tggggctgcc
    20461 tgcacctgct ggaccgcgag gtcgacgtca tccccaccat ccactccacc ctcgaggtcg
    20521 aggacgtcct gctgcaccgg ctgccggaac tcaccgaact ggtcatcgtc cccggccgga
    20581 acaaggaacc gctgccggtc gtctgcaccc gtggcgacgc cccgatcgac ctcgaccgct
    20641 ggcgcgccgc cgtcgccgac caggccgcca tggcggaccc ggtccagctg cggctcgacg
    20701 aactgccgcg caccgccacc gcgaagatca agcgcctgga gctggcctcc cgcctgacgg
    20761 ccgcccggga accgcagccc gccggacagc tctgctgacc cgccctgccc caccggccct
    20821 caccggccgc ctgacttccc tgacctcccc gacctccctg acctccctga cctcccgaag
    20881 aaccaccgag tgacgaagcg tcaccccacc gacccgcgaa ccccacccct gacccgaagg
    20941 aagaccccga tgtcacagct cgccgagaac gagacggccc gccgccgccg gctcgggctg
    21001 accctggccc tgctggcctt cgcccagctc atcatctcca tcgactacaa catcgtgtac
    21061 gtcgcccttc ccgagatcgg ctcggccctc ggcttcaccg cgcagaacct ccagtgggtg
    21121 gtcagcgcct acgccgtcgc cttcggcggg ttcctgatgc tcggcggccg cgcctgcgac
    21181 ctgttcggcc cgcgccggat gttcgtcctc ggcctcagcc tgtacgccgg ctcctcgctg
    21241 ctcggcgccc tcgcccagga gcccggcctg ctgatcgcct cccgcgccgt gcagggcatc
    21301 ggcggcgcgt tcctcttccc cgccaccctc accctggtct ccaccagctt cgccgagggc
    21361 aaggagcgca accgcgcctt cgccgtctgg ggcaccgccg gcggcagcgg catgatcgtc
    21421 ggctcgctgc tcggcggcgt cctcacccag gcgttcggct ggagctcggt cttctacatc
    21481 aacgtgctgc tggccggcgt cgccgcgctg ctcgccttcc cgctgatcag ccccgacgcc
    21541 acccgcaaga gcggccgcgg cttcgacctg gccggcgcgc tcacctccac catcggcatc
    21601 accgccgtgg tcttcgccct cggccagggc ccggtctccg gctggggctc gctgccggtc
    21661 gtcggcgcct tcgtcgccgg cgccgtgctc ctcgcgctgt tcttcgcgat cgagaagcgc
    21721 tccgcggacc cgctgctccc gctgcgcctg ttcgccaacc gcaacctcac caccgccacc
    21781 gccgtcacct tcgcctacat gggcaccttc ggcaccctgc tgtacttcct caccgtctac
    21841 ttccagggcg tgcacggcta caacgccctc gacaccggcc tggcgttcct cgtcccgatg
    21901 gtcgccatcg ccttcggcgc ccagaccgcg ggccgcctgg ccacccgcta cggcatccgc
    21961 gccatcatga tcgcctcgct gctgatcggc gtcgtcggcg ccggcatcgt cggcgtcacc
    22021 atggccgccg acgcctccta cctggtcctc gtccccggcc tgatcgtgct gggcgtcggc
    22081 cagggcgccg gctacaccct gatgttcggc gccgccgcgg tcggcatcga accccaggac
    22141 cagggcatcg cctccggcgc cgcctccacc acccagcagg tcggcggcgc cgtcggcctc
    22201 gccgtcctgg tcgccgtcgc caactccggc ctgtccggca agaccggcga ggccctgcgc
    22261 gtcgccacct ccgacggcac ccgcaacgcc ttctacctcg ccgccgtcgg catcctcatc
    22321 accgccgtca tcgccctcgg cctccgcaag cccgaacccc gcgccaccac cggctccacc
    22381 gccgacgcgg ccgccgacac cctggagaag gccggcgtct gacccgcccc ctcccgcccc
    22441 acccctgcga gagccccccg ccacccggcg gggggctctc gcacgcgcgc ggccgggccg
    22501 ttcaggagag ggggacggcg gcggcgagct cccgaacccc tgcggctcgc gggtggcggg
    22561 tcacgaggtc gctgacgacc gctcggatgg aggatcggtc gcggatctcg gccgggctcg
    22621 ctcggagtgc cgagagaagt tcgttcgccg tctgctctgg gcgcccccac tgccaccagg
    22681 cgcgtgccag gtcggtgtgc agtcgggcgc gccgttcggc ggtggggaac tgctccggcc
    22741 gcaggttgcg gccggcttcg agggcggccc ctgcgtcgcc gagggcccag tggacgctga
    22801 cggcgtagag gtcggccgct gccggggtga tggtgaacag gctcccggtg ccgggggtgg
    22861 cgggcagtcg gcgggcggcg ttccgggctt cggccatcat ggcgacggct tccgtgcgct
    22921 ggccggcgac cgccgcggtg taggcgaggg tgcacagcag ttgggcgtag gccgccgtct
    22981 ggggctgggt ggtgagtccg gtgttctcca ggcggtcgac ggcggtgagc atcagccgct
    23041 gcgcggcggg ggcccggtcc tggtgcctca gcacgacggc cgcctcgcgg gtggcggcgg
    23101 cctgggccag cggcgagccg gacacctctg cccaggtacg ggcgcggtcc gcggtcaacc
    23161 gggcccggtc gtagtggccg gtcttgatca ggactgcggt ggcgaggctg tagaccgtgg
    23221 acagccgggc ctggtcgagg tcgcgccggg agtcggcggc ggcgtgggcg tcggcgatca
    23281 ggccgggcag aacctcaagg agtcgggcgt gcgctccggt gtcgaacagg tcgcgggcgc
    23341 ggttcaggac ctggtcgagc tgcgcggcgt tgcgggtcgg cccgggtgtg tcggcgagcg
    23401 cgtcgtccag ccctaggagt aaggccgccg gcccggccac ggtggcggcg gcgacaagcg
    23461 ttcggcggcg cataggactc tcctcggcct ggcggaaact gccggccact ctatccgtgt
    23521 ggtggccggt cgacgggccc agcgcaaggg aagtcaccag tacgtggcgc ggcattccga
    23581 cttcgatcgc ggcctgccga aggagtgcca ggtccacgat tcggttggcg cgttcgagac
    23641 ggctgaccgt ggagggcgag actcccaggc ggcgctcgag ggcttccagt gtccagtcgc
    23701 ggtgctggcg tcccaggcgc accagttcac ctgggcggtg ctgctccgcc agcgaccggg
    23761 ctttcggggt gctccacagt gagtccggca cgggacctcc caggcgacac aaccggggct
    23821 caccaacggt acacatgatc cgacagtccg tcgacgatgc ttgcatgccg tgcaaaacag
    23881 ttccagggta agcaagttga ccactccggc tatccgggtg gtggtgtgct gttcgcaccg
    23941 tccggggcca tcccggaccc gaagtcggag gaaccatggc aacctcgacc gctcccgccg
    24001 accagatcac cggcctgttc cggaacgtgc gtgaccacgt ccccgccgac ctgtgggaca
    24061 agcagatcgg cctgctgatg cgcgaccacc cctacgactc cgtcatggcc gcccgcgtcc
    24121 tggggcaggg ctacgcctac ctgctcaccg cgatggccca ccgcgacgag cacctgggtc
    24181 tgggccccag ctcgctggtg gacatcggcg tccacacgat cgtcctggac accgtcgcct
    24241 acgccgagct gtgccgtgtc cacaacggcg gccgcttcct gcaccacgtg ccggccgtcg
    24301 agttcaagca ggacggcacc gtgccgcgca ccgcccagct gatcgccgcc gagggctggg
    24361 aggtggacct gcccttgtgg gcggacgccg ccggctgcag cccctgccac cccggcaacg
    24421 actcgcactg accggtcatc gggcggcccc gggacccccg gggccgcctt ccgcccggga
    24481 gggtggagtt cccccgaagt cctccgccgg tacgcggcgg gcgcgaggat ggcacgggtg
    24541 acgaccaccc cgccggacct ctggcaccac tacggccgcg cccgctccga cagcgaccgc
    24601 gccgttcctc cggttttctc ctgggtctgg gcccaggacg cgggccccgg ggccgaggtc
    24661 ctgggcgacg tcaccggcct cgtcgtcgcc gacctcggcg ccggtgtcgc ccgccacgcc
    24721 gcccacctcg tcgcccgcca cgccccggcc cgggtcgacg ccgtcgactc ctccgccgcc
    24781 cagcacgcga gggcgcgtga cctgtacggc cacctcgcgc cgcggttgcg cgccgtgcac
    24841 gccgacgcgg tcgaccactt ggacgcccac cccggctcgt acgacgtcct ctgctcggtg
    24901 ttcgggagtc tggacttcac cgatccccgc cgactgctcc ccgccgctgc ccgggccctt
    24961 cggccgggcg ggctgctggt ggcttccact ct
//
