LOCUS       NC_016109              11276 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6175104
            Orig. end                         :: 6186380
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11276
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="30"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11276
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11276
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6276](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6276)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    702..717
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.09"
                     /tool="antismash"
     gene            865..2268
                     /gene="hemG"
                     /locus_tag="KSE_RS27280"
                     /old_locus_tag="KSE_55130"
     CDS             865..2268
                     /EC_number="1.3.3.4"
                     /GO_function="GO:0004729 - oxygen-dependent
                     protoporphyrinogen oxidase activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138585.1"
                     /locus_tag="KSE_RS27280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55130"
                     /product="protoporphyrinogen oxidase"
                     /protein_id="WP_014138585.1"
                     /sec_met_domain="DAO (E-value: 2.4e-09, bitscore: 36.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKPHVVVIGGGIAGLAAAAFLSDAAVRVTVLEASTRFGGKLRGG
                     EVGGVRVDLGAESMLARRPEAVELARLVGLGERLEPPTTAKAALWTRDALRPLPGGQLM
                     GVPGDLDALAASEVLTPEGLERARHERPAEIGEDAPIGRYIADRLGREVVDRLVEPLLG
                     GVYAGHADEISIRAAVPQLLPLARQGGSLTAAIRALSTRAGAGGPVFQGLRGGLGTLPG
                     AVAAHARAHGAELLTGHPVDALRRTPDGWRIATAGRELAADAVVLAVPAPQAAALLAAD
                     APAAAAELRAVEYASMALVTLAFRRADLADSPLTGSGFLVPPVDRRAIKASTFSSNKWG
                     WLERSAPDAFLLRTSLGRHREDAALDLDDAELVARSLADLRTAVGLRAVPYDHAVTRWR
                     AGLPQYPVGHLDRVARIRAHLDALGAVAVCGAAYDGVGIPAVVGGARRAAEHLTPRTSG
                     TRTEGTMGA"
     gene            2265..2975
                     /gene="hemQ"
                     /locus_tag="KSE_RS27285"
                     /old_locus_tag="KSE_55140"
     CDS             2265..2975
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138586.1"
                     /locus_tag="KSE_RS27285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55140"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_014138586.1"
                     /transl_table=11
                     /translation="MTESTEQPVKKKARDLNQVIRYTMWSVFKLKDALPEDRTALTAEV
                     DALFEQLAAKDVVVRGTYDVSGLRADADLMVWWHAEDSDDLQEAYNRFRRTGLGRLLEP
                     VWSNMALHRPAEFNKSHIPAFLADEQPREYVCVYPFVRSYEWYLLPDEERRGMLAEHGK
                     MARGYPDVRANTVASFALGDYEWLLAFEADELHRIVDLMRDLRPSRARLHVREEVPFFT
                     GRRKPVADLLAGLY"
     gene            complement(3031..3801)
                     /locus_tag="KSE_RS27290"
                     /old_locus_tag="KSE_55150"
     CDS             complement(3031..3801)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014145395.1"
                     /locus_tag="KSE_RS27290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55150"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_014138587.1"
                     /transl_table=11
                     /translation="MWVLLLVPSCAAAVLSCLRLVRVAAIADAAAGRAPAGVAGRPPGV
                     GLYETAYLAGGPARVVELALVRMAGVGRLHLAHTGWTTVVDPLGRGRLERALIGAIGPE
                     GQCRTSQLKAALAAHPTVRDIGDRLARAGLATPAVVRDHALRAVRQVRYALFGAAAMLL
                     LTVLLSGTDAETARTAVAWYALPLVLTGGTLLMARVDVHAYTAWAAPAGQTLLRTLPCR
                     HTAATATDDDLLTAVAISGPAAVRDPRLRAALDS"
     misc_feature    3772..3787
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     misc_feature    3801..3810
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.33"
                     /tool="antismash"
     misc_feature    complement(3806..3821)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            complement(3893..4960)
                     /locus_tag="KSE_RS27295"
                     /old_locus_tag="KSE_55160"
     CDS             complement(3893..4960)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="KSE_RS27295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55160"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_014138588.1"
                     /transl_table=11
                     /translation="MSNHLFVLAVALVALALTAVTVFNARSRRVTDPLGLPGRGQSLSE
                     VAFLAGGPARVVDTALVRMEREGRLVVSRARRVTVTDDRTADPVERVLVTAAGGRAGRD
                     LSVLRASVTGSPEVQKTGDGLAARGLLRNPAALRAAWRARRLLVLALAAAVAFGAVDTL
                     RWLGEPDRYNVFPPFLGYALLVLFTVVSLVVTRPRRSRITPAGLRQLQLVRGSTPWRPR
                     EVAAEHAELVGAFALDGAAALRDPEHRALREALTGPYSSTVTITLGKRSGRSGRDSGSS
                     GGWDSAAGAGAGAGAGAWCGSSGSSCGASGHSGGHSGGHSGGHSCGGSSHSCGGGGHSC
                     GGGSSCGGGGCGGGS"
     gene            complement(5001..6276)
                     /locus_tag="KSE_RS27305"
                     /old_locus_tag="KSE_55180"
                     /pseudo=""
     CDS             complement(5001..6276)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888544.1"
                     /locus_tag="KSE_RS27305"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55180"
                     /product="DUF692 domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DUF692 (E-value: 6.4e-89, bitscore: 296.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSVIPRLGTGLGWRPEIDTAVERLPGLDWVEVVAENVCADHLP
                     PSLAELRARGVTVVPHGVSLGLGNAAEPDPARLARLAGVAEAVGAPLVSEHLAFVRAGG
                     LEAGHLLPVPRTREALEVVAANVRIAQRELPVPLALENIAAHLAWPDDELTEAQFLAEL
                     VERTGVRLLVDVANLHTNRVNLGVDPAAELDRLPLDALAYVHVAGGVERDGVWHDTHAH
                     PVTAPVLDVLAALCARADPPGVLLERDGAYPPPAELSAELDAIRRVQHLHRRETARV"
     gene            6475..7395
                     /locus_tag="KSE_RS27310"
                     /old_locus_tag="KSE_55190"
     CDS             6475..7395
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014157116.1"
                     /locus_tag="KSE_RS27310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55190"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_014138591.1"
                     /transl_table=11
                     /translation="MTSQPYRIRPFTPADADGAAEAYRAGRPHLVTTPEVVAWQSRLPH
                     YHLLVAELAGRVVGTARFGPVTESTTPHQGFLTVSVLPERRGTGAGTALLAAAERELAA
                     LGVRDAHSWVDETPEALGFAAARGYRKSGRAGHFGRLDLTAPLPPLPPVPPGVELRTAA
                     DFLDDPYPIYLVDIDGTRAEPGDLVLDDQPYEGWLAEIWQRPDQDHTLTAVAVADGEAV
                     AFSAAQTDGRGAYWSAFTATRSSHRGRGLAKLAKAHSLHLAKARGLTAAYTQNDAGNAP
                     MLAINAWFGYRECATEWKHTRSLSG"
     gene            7505..8035
                     /locus_tag="KSE_RS27315"
                     /old_locus_tag="KSE_55200"
     CDS             7505..8035
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS27315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_55200"
                     /product="hypothetical protein"
                     /protein_id="WP_014138592.1"
                     /transl_table=11
                     /translation="MPRRPRRAARLAAVLPLLAAPAVLAPPAAHAEPVAMVCTGTGQQA
                     YRPGITLTTRPTTVTNTSDLTACTGGPVGSGHHRFGPFATTASCLYTPPTGPDAFDLSW
                     DDGTTSHYEGSYLVTTAGGQLVVTSTGTVTAGRFAGAALREVVAYLAPDLLRCATPQGV
                     TSVSGPITIAVTG"
     gene            complement(8088..10187)
                     /locus_tag="KSE_RS27320"
                     /old_locus_tag="KSE_55210"
     CDS             complement(8088..10187)
                     /EC_number="3.1.21.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_process="GO:0009307 - DNA restriction-modification
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1296: tellurium
                     resistance protein, TerD"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF014404.5"
                     /locus_tag="KSE_RS27320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55210"
                     /product="restriction endonuclease"
                     /protein_id="WP_014138593.1"
                     /transl_table=11
                     /translation="MWSVLAEAQREQHRRAEEQRRAAAAAQREQERARREAQRAAARGE
                     REALRAYQQGRESDAARRTAELDGRVAELRGVLAAGLAGPGFSLALPERPVVPPFDPGP
                     LGVPVPMPDQNWYLVPPPAGPQAYQPGARRQWEEQAARARARFEHDWQAAWAAEQHRQR
                     QLADHRARYDAWAAERHRLLAGQSAQAGLLAGRLRAGEAAAVAEYFEAVVDWREDWPDG
                     FPADGETSWDAAARRLVVRWELPPYEVVPAVGRYRYVRSDDREDEVARPAGQRRELYRE
                     VLAQSALRVLAEVFRADREGLLGSVGLNGVLVATDPATGRDAERCLLAVEVDREVFAGL
                     ALDRVAAVDCLVGALGGRLSARPEKAEPVAEVPASVEPVGPVAAPEPVAADGGGPDLFE
                     MDPLEFEELIAELFRRRGLRTSTTARSGDEGVDVLAEDPDPITGGKIVIQAKRYRRTVP
                     PSAVRDLESTMRRQGANRGILVTTAGFGPGSRKHAEGQPLTLVDGPMLLELLREQGLPG
                     RLGPAAAPAIPVQRSSPAAELTPGQNLVLPHGELRVLFRAGGAAADLTLLLLDADGRVR
                     RDEDFVFYHQPSAERGAVTLDPAGRSATVRTGRLPDSVRRVAVSVNLDADGDGTCADLV
                     DPAVELSSGDGRWVFRPPADPAVSAMLVAEVYRHPADGWKLRAVGQGWSDGLAGLARAH
                     GVDVA"
     gene            complement(10336..10740)
                     /gene="msrB"
                     /locus_tag="KSE_RS27325"
                     /old_locus_tag="KSE_55220"
     CDS             complement(10336..10740)
                     /EC_number="1.8.4.12"
                     /GO_function="GO:0033743 - peptide-methionine (R)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138594.1"
                     /locus_tag="KSE_RS27325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_55220"
                     /product="peptide-methionine (R)-S-oxide reductase MsrB"
                     /protein_id="WP_014138594.1"
                     /transl_table=11
                     /translation="MSYEVQKSDAEWRAQLSPEEYHVLREAGTERPFVGEYTDTKTVGV
                     YACRACGAELFSSETKFDSHCGWPSYYAPLAGDSVEYLEDTSLGMRRVEVRCKNCGSHL
                     GHVFEGEGYGTPTDQRYCINSISLTLKPAE"
     misc_feature    complement(11001..11019)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.03"
                     /tool="antismash"
ORIGIN
        1 gggactccag atcggactcg cggcgggtca gctcgctctc cagcgagacc acctcggaca
       61 ggctcttcgc gcccgccatc agcgcccgca cccggtccac gctggcctgc atggacttca
      121 gccggctgtc gacgtcggcg atctggtcgg tcaggtcgtc ggcctggctg ctcaggccca
      181 gccgggtgcc gaccgcgccg agcccgtcca gcacggcctg gtaggacgcg gacgggacct
      241 tcagggtcag cgtggcctgc cggctctcgc ccggcccgcc gcgcaggttc tccccggcca
      301 cgtagccgcc cgcccgggtg accaggtcga cggccctggc gcgggcgtcc tcgaccgcgt
      361 cgacccgcag ggtcagcctg ccctggtagg cgatccggcg gtcggccggg gcggcggtcg
      421 cgccgccgcc gggggtggcc ccggccccgg gcgcggcgtc gcccttgccg ggggcggccg
      481 ccggcttggc ggcgccctgg gcgccggcct gggccccgcc ctgggcgtcg gccgccgcgg
      541 ccgggccgac cgccgacgag gccgtccccg cgcggtcgga tcccgccccg cacccggcca
      601 gcagcagcac cgccgccagc gcccccgccg cgccgattct ccgcacccgc aggtccattc
      661 cggttcctcc ccgtgtcccc ggggcgggcc gaccgcccgt ccccacggct ctgtgacgcg
      721 gcggcccccg gaccggaccc gcactcccgg taccggatgg atcacgcccc ggactcgccc
      781 cggtctcgac accgcccgcg ccgccgcccg aggtcgtccg ggtcgattcc ggcgaaccgg
      841 ataaaggctg ggagactgac cggcatggcg aaacctcacg tggtggtcat cggtggcggg
      901 atcgcgggcc tggccgcggc cgcgttcctc tcggacgcgg cggtacgggt caccgtgctg
      961 gaggcgtcga cgcgcttcgg cgggaagctg cgcggcggtg aggtcggcgg cgtccgggtc
     1021 gacctcggcg ccgagtcgat gctcgcccgc cgccccgagg ccgtcgaact ggcccggctg
     1081 gtcggcctcg gcgagcggct cgaaccgccg accaccgcca aggccgcgct ctggaccagg
     1141 gacgccctgc gcccgctgcc cggcggccaa ctcatgggcg taccgggcga cctggacgcc
     1201 ctcgcggcct ccgaggtgct cacccccgag ggcctggagc gggcccgcca cgagcggccc
     1261 gccgagatcg gcgaggacgc cccgatcggc cgctacatcg ccgaccggct cggccgcgag
     1321 gtggtcgacc ggctggtcga accgctgctc ggcggggtct acgccgggca cgccgacgag
     1381 atctcgatcc gcgccgccgt cccgcaactg ctcccgctgg cccgccaggg cggctcgctg
     1441 accgccgcca tccgcgcact cagcacccgc gccggcgccg gcggaccggt cttccagggc
     1501 ctgcgcggcg gactcggcac cctccccggg gcggtcgccg cccacgcccg cgcgcacggc
     1561 gccgaactgc tcaccggcca cccggtcgac gcgctgcgcc gcacccccga cggctggcgg
     1621 atcgccaccg ccggccgcga actcgccgcc gacgccgtcg tgctggccgt ccccgccccg
     1681 caggccgccg cgctgctcgc cgccgacgcg cccgccgccg ccgccgaact gcgtgccgtc
     1741 gagtacgcgt cgatggccct ggtcacgctc gccttccgcc gcgccgacct cgcggacagc
     1801 ccgctcaccg gcagcggctt cctcgtcccg ccggtcgacc ggcgcgccat caaggcgtcc
     1861 accttctcca gcaacaagtg gggctggctg gagcgctccg cccccgacgc cttcctgctg
     1921 cgcacctcgc tcggccggca ccgcgaggac gccgccctcg acctggacga cgccgaactc
     1981 gtcgcccgct cgctcgccga cctgcgcacc gccgtcggcc tgcgggccgt cccgtacgac
     2041 cacgccgtca cccgctggcg ggccggactg ccgcagtacc ccgtcggcca cctcgaccgg
     2101 gtcgcccgga tccgcgccca cctcgacgcg ctcggcgcgg tcgccgtctg cggcgcggcg
     2161 tacgacggcg tcggcatccc cgccgtcgtc ggcggcgccc ggcgcgccgc cgagcacctc
     2221 accccccgca ccagcggcac ccgcacggaa gggacaatgg gcgcatgacc gaaagcactg
     2281 agcagcccgt gaagaagaag gcccgcgacc tcaaccaggt catccgctac accatgtggt
     2341 cggtgttcaa gctcaaggac gccctcccgg aggaccgcac cgccctcacc gccgaggtcg
     2401 acgccctctt cgagcagctc gccgccaagg acgtggtggt ccgcggcacc tacgacgtct
     2461 ccggcctgcg cgccgacgcc gacctgatgg tctggtggca cgccgaggac tccgacgacc
     2521 tccaggaggc gtacaaccgc ttccgccgca ccggcctcgg ccgcctgctg gagccggtct
     2581 ggtcgaacat ggcgctgcac cgccccgccg agttcaacaa gtcgcacatc ccggcgttcc
     2641 tcgccgacga gcagccccgc gagtacgtct gcgtctaccc cttcgtccgc tcctacgagt
     2701 ggtacctgct cccggacgag gagcgccggg ggatgctcgc cgagcacggc aagatggccc
     2761 gcggctaccc cgacgtccgc gccaacaccg tcgcgtcctt cgcgctcggc gactacgagt
     2821 ggctgctcgc cttcgaggcc gacgagctgc accggatcgt cgacctgatg cgcgacctgc
     2881 gcccctcccg ggcccggctg cacgtccgcg aggaggtccc gttcttcacc ggccgccgca
     2941 agccggtcgc cgacctgctg gccggcctct actagtgccg ctcgggaccg gccgcaccgg
     3001 gaccggcccg gccggtcccg gcaggggcgg tcaggagtcg agcgcggcgc gcaggcgcgg
     3061 gtcgcggacg gccgccgggc cggagatggc gacggcggtg agcaggtcgt cgtcggtggc
     3121 ggtggcggcg gtgtgccggc agggcagggt gcgcagcagg gtctggccgg ccggggcggc
     3181 ccaggcggtg taggcgtgga cgtcgacccg ggccatcagc agggtgccgc cggtgaggac
     3241 cagcggcagg gcgtaccagg cgacggcggt gcgggcggtc tcggcgtcgg tcccgctgag
     3301 caggacggtg agcagcagca tcgcggccgc cccgaacagc gcgtacctga cctgccggac
     3361 cgcccgcagc gcgtggtcgc ggacgacggc gggggtggcc agcccggccc gggccagccg
     3421 gtcgccgatg tcccggacgg tcgggtgggc ggccagcgcc gccttcagct gggaggtgcg
     3481 gcactggccc tcggggccga tcgcgccgat cagggcccgc tccaggcggc cgcggcccag
     3541 cgggtcgacg acggtggtcc agccggtgtg cgcgaggtgc agccggccca ccccggccat
     3601 ccggaccagc gccagctcga ccacccgggc ggggccgccg gccaggtacg cggtctcgta
     3661 gaggccgacg cccggcgggc ggccggcgac ccccgccggg gcccgcccgg cggcggcgtc
     3721 cgcgatcgcg gcgacccgta ccaggcggag gcaggagagc accgcggcgg cacaggacgg
     3781 gaccagcagc aagacccaca tggtttttgt tctagtcctg tgggtggcgg aaacggaacg
     3841 aatctccgtg ccgcgatacc gaactgtgac gcggcggacg cccggcggac actcaggaac
     3901 cgccgccgca gccgcccccg ccgcagctcg acccgccgcc gcaggagtgc ccgccgccac
     3961 cgcacgagtg cgaggacccg ccgcaggagt ggccccccga gtgcccgccc gagtggcccc
     4021 cggagtgccc ggacgcgccg caggaggagc cggacgagcc gcaccaggcc ccggcgcccg
     4081 cccccgcccc ggccccggcc gcggagtccc agccgccgga cgacccggag tcccgcccgg
     4141 agcgcccgga gcgcttgccg agggtgatgg tcacggtcga ggagtacggc ccggtgagcg
     4201 cctcgcgcag cgcccggtgc tcggggtcgc gcagcgccgc ggcgccgtcc agggcgaacg
     4261 cgccgaccag ctcggcgtgc tcggccgcca cctcccgggg ccgccagggc gtgctgccgc
     4321 ggaccagctg gagctggcgc aggcccgccg gggtgatccg gctccggcgg gggcgggtga
     4381 cgaccaggct gaccaccgtg aacagcacca gcagcgcgta gcccaggaac ggcgggaaga
     4441 cgttgtaccg gtcgggctcg cccagccagc ggagggtgtc gaccgcgccg aacgccaccg
     4501 cggcggccag cgccagcacc agcagccgcc gggcccgcca ggcggcccgc agcgcggccg
     4561 ggttccgcag caggccgcgg gcggccagcc cgtcgccggt cttctgcacc tcggggctgc
     4621 ccgtcacgga ggcgcgcagc acggacaggt cgcgtccggc ccggccgccg gcggcggtga
     4681 ccaggacgcg ctcgaccggg tcggccgtcc ggtcgtcggt gacggtgacc cggcgggccc
     4741 gcgagacgac cagccggccc tcgcgctcca tccggaccag cgcggtgtcg accacccgcg
     4801 cgggcccgcc ggccaggaag gcgacctcgg acagcgactg gccgcgcccg ggcaggccca
     4861 gcgggtcggt gacccggcgg ctgcgcgcgt tgaagacggt gacggcggtg agggcgagcg
     4921 cgaccagcgc gaccgccagg acgaacaggt ggttcgacat cccccgtggt tcctttcggc
     4981 gtcggtggtt cggggtgcgg ctacgggtgc gcgggcgcgc tgcgggcgcg gcgcggcagc
     5041 agccggcccc accgggaggc ggcgggccgc agcaggcggc gcagcgcggg ctgccagcgg
     5101 gcggcgggct cggcggccag cgcccactcg gcgaaggcca gggcgtccgc gcggtagccg
     5161 ccggtgagcg gccggccggc cgcgtagcgg gcgaacagcg gggcgaagtc cgggccgagc
     5221 agttcgggca gttccggcag caggtggccg acggtctccc ggcgcttggc gcgcaggccc
     5281 tcggcctgca cccgcagctg ctccgggtcg aagccgggcg gcggcggggc ggcggccacc
     5341 agggcggcca gcagccgctc ctggcggtgc gccaggtgga cccgggcgag ggcgagttcg
     5401 gcgtcggcgc ggtcgcggat caggtactcg tgctgctcag acacgggcgg tctccctgcg
     5461 gtggaggtgc tggacgcggc ggatggcgtc gagttcggcg gacagttcgg cgggcggcgg
     5521 gtacgcgccg tcccgttcca gcagcacccc gggcgggtcg gcccgcgcgc agagcgcggc
     5581 cagcacgtcc agcacgggcg cggtgaccgg gtgggcgtgg gtgtcgtgcc agacgccgtc
     5641 gcgctcgacg cccccggcga cgtgcacgta ggcgagggcg tccagcggca gccggtcgag
     5701 ctcggcggcc gggtcgacgc ccaggttgac ccggttggtg tgcaggttgg cgacgtccac
     5761 cagcaggcgg acgccggtgc gctcgaccag ttcggccagg aactgggcct cggtcagctc
     5821 gtcgtccggc caggccaggt gggcggcgat gttctccagc gcgagcggca ccggcagctc
     5881 ccgctgggcg atccggacgt tcgcggccac cacctccagc gcctcccggg tgcgcggcac
     5941 cggcagcagg tgcccggcct ccaggccgcc ggcccggacg aacgccaggt gctcgctgac
     6001 cagcggcgcc cccaccgcct cggcgacgcc cgccagccgg gccagccggg ccgggtcggg
     6061 ctcggcggcg ttgcccaggc cgagcgagac gccgtgcggg acgaccgtga cgccgcgggc
     6121 gcgcagctcg gccagcgagg gcggcaggtg gtcggcgcag acgttctcgg cgaccacctc
     6181 cacccagtcg agaccgggca gccgctccac cgcggtgtcg atctcgggcc gccagcccag
     6241 accggtgccc aagcgcggaa taacggacga agacatattt ccaccccctt tcgcggggtt
     6301 ttccggtcat gcgggacccc gttgtcgagg gtgtgtccac ggcgggcgga tgccaagcgg
     6361 gacaccggaa actcagagct gaacttgagc tttccgctcc actgaacgaa cagccgggcg
     6421 ggtgggggaa attcagcagc gcacggacgg actactggct aacgtgacat gcctatgact
     6481 tcgcagccgt accgcatccg accgttcacc cccgccgacg ccgacggggc cgccgaggcc
     6541 taccgggcgg gccgcccgca cctggtcacc acccccgagg tggtcgcctg gcagagccgc
     6601 ctgccgcact accacctgct ggtcgccgag ctggccggcc gggtcgtcgg caccgcccgg
     6661 ttcggcccgg tgaccgagag caccaccccg caccagggct tcctcaccgt cagcgtgctc
     6721 cccgagcggc gcggcaccgg cgccggcacc gcgctgctcg ccgccgccga gcgcgagctc
     6781 gccgccctcg gcgtccggga cgcgcacagc tgggtcgacg agacccccga ggccctcggc
     6841 ttcgccgccg cccgcggcta ccgcaagagc ggccgggccg gccacttcgg ccgcctcgac
     6901 ctgaccgccc cgctgccccc gctgccgccc gtcccgcccg gcgtcgaact gcgcaccgcc
     6961 gccgacttcc tggacgaccc gtacccgatc tacctggtcg acatcgacgg cacccgcgcc
     7021 gaacccggcg acctcgtcct cgacgaccag ccgtacgagg gctggctggc cgagatctgg
     7081 cagcgccccg accaggacca caccctcacc gcggtggccg tcgccgacgg cgaggcggtg
     7141 gccttctccg ccgcccagac cgacggccgc ggcgcctact ggtcggcctt caccgcgacc
     7201 cgctccagcc accgcggccg cggcctcgcc aagctcgcca aggcccactc gctgcacctg
     7261 gccaaggccc gcggcctgac cgccgcctac acccagaacg acgccggcaa cgcgccgatg
     7321 ctcgccatca acgcctggtt cggctaccgc gagtgcgcga ccgagtggaa gcacacccgg
     7381 tccctgagcg gctgaccgcg cggcaccccg cccccgtccg ggggaagccg ggggagcggc
     7441 ggtacgggaa ccgggccggg ccgggaacga gggcacccac ccctcccctc ccgaaggagc
     7501 ccccgtgccc cgccgccccc gccgcgccgc ccgcctcgcc gccgtcctgc cgctgctcgc
     7561 cgccccggcc gtgctcgccc cgcccgccgc ccacgccgag ccggtggcga tggtctgcac
     7621 cggtaccggg cagcaggcgt accgccccgg catcaccctc accacccggc cgaccacggt
     7681 caccaacacc tccgacctga ccgcctgcac cggcggcccg gtcggctccg gccaccaccg
     7741 gttcgggccg ttcgcgacca ccgcgagctg cctgtacacc ccgccgaccg gccccgacgc
     7801 cttcgacctc agctgggacg acggcaccac cagccactac gagggcagct acctggtgac
     7861 cacggccggc ggccagctcg tggtcaccag caccggcacc gtcaccgccg gccgcttcgc
     7921 gggcgcggcg ctgcgcgagg tggtcgccta cctcgccccc gacctgctgc ggtgcgccac
     7981 cccgcagggc gtcaccagcg tctccgggcc gatcaccatc gccgtcaccg gctgagccgc
     8041 ggccgtcccg cgcggcggcc gcggccgccg ccgctcggga cgctccgcta cgcgacgtcc
     8101 acgccgtggg cgcgggccag acccgccagg ccgtccgacc agccctggcc gaccgcccgg
     8161 agcttccacc cgtcggccgg gtgccggtag acctcggcga ccagcatcgc ggagaccgcc
     8221 gggtcggccg gcggccggaa cacccagcgg ccgtcgccgg aagagagctc gaccgccggg
     8281 tcgaccaggt ccgcgcaggt gccgtcgccg tccgcgtcca ggttgaccga gacggccacc
     8341 cgccggaccg agtccggcag tcgcccggtc cgcacggtcg cgctgcgccc ggccgggtcg
     8401 agcgtgacgg cgccgcgctc cgcgctcggc tggtggtaga agacgaagtc ctcgtcccgc
     8461 cggaccctgc cgtccgcgtc gagcagcagc agcgtcaggt cggccgcggc cccgcccgcc
     8521 cggaacagca cccgcagctc gccgtgcggc agcaccaggt tctggcccgg cgtcaactcg
     8581 gccgccgggg agctgcgttg aacggggatc gcgggggcgg ccgccgggcc gaggcggccc
     8641 gggaggccct gctcgcggag cagctccagc agcatcggcc cgtcgaccag ggtgagcggc
     8701 tggccctcgg cgtgcttgcg cgaaccgggc ccgaagcccg ccgtggtgac caggatgccc
     8761 cggttggcac cctgccggcg catcgtcgac tccaggtcgc ggacggcgct cggcgggacg
     8821 gtcctgcggt agcgcttggc ctggatgacg atcttcccgc cggtgatcgg gtccgggtcc
     8881 tcggccagca cgtccacgcc ctcgtcgccg ctgcgcgcgg tggtgctggt gcgcaggccc
     8941 cggcggcgga acagctcggc gatcagctcc tcgaactcca gcgggtccat ctcgaacagg
     9001 tcaggacccc cgccgtccgc cgccacgggc tccggcgccg ccaccggccc caccggctcg
     9061 accgaggccg gcacctcggc gaccggctcg gccttctccg gccgggccga cagccgcccg
     9121 cccagcgcgc cgaccaggca gtccaccgcg gcgacccggt ccagcgcgag gcccgcgaag
     9181 acctcccggt cgacctcgac ggccagcagg cagcgctcgg cgtcccgccc ggtcgccggg
     9241 tcggtggcca ccagcacgcc gttcaggccg accgagccga gcagcccctc gcggtcggcc
     9301 cggaacacct ccgccagcac ccgcagcgcg ctctgcgcca gcacctcgcg gtacagctcc
     9361 cggcgctgcc cggccggccg ggccacctcg tcctcgcggt cgtccgagcg gacgtaccgg
     9421 taccggccca ccgccggcac cacctcgtac ggcggcagct cccagcgcac caccagccgg
     9481 cgggcggcgg cgtcccaaga ggtctcgccg tcggcgggga agccgtccgg ccagtcctcg
     9541 cgccagtcga cgaccgcctc gaagtactcg gcgaccgccg ccgcctcgcc cgcccgcagc
     9601 cgcccggcca gcagcccggc ctgcgcggac tgcccggcca gcagccggtg ccgctcggcc
     9661 gcccacgcgt cgtaccgcgc ccggtggtcg gccagctgcc gctgccggtg ctgctcggcc
     9721 gcccaggccg cctgccagtc gtgctcgaac ctcgcccggg cccgcgccgc ctgctcctcc
     9781 cactgccgcc gcgcccccgg ctggtacgcc tgcgggcccg ccgggggcgg caccaggtac
     9841 cagttctggt ccggcatcgg caccggcacg cccagcggac cggggtcgaa cggcggcacc
     9901 accggccgct ccggcagcgc cagcgagaac cccgggccgg ccagcccggc cgccagcacc
     9961 ccgcgcagct cggcgacccg cccgtccagt tcggccgtcc gccgggccgc gtccgactcc
    10021 cgcccctgct ggtacgccct cagcgcctcg cgctcgcccc gggccgccgc ccgctgggcc
    10081 tcccgccggg cccgctcctg ctcgcgctgc gcggccgcgg ccgcccggcg ctgctcctcc
    10141 gcccggcggt gctgctcgcg ctgcgcctcg gccagtaccg accacacccc ggaagaccgc
    10201 cgccgtgcca cgcccgcccc acccacgtcc ccagacccgt tcggaaggtg atcagtctcg
    10261 cacgcccgcg ggcacgcgcg agggccctcc ccggccgccc ggggagggcc ctcgtcggcg
    10321 cggccggccg gcggcctact cggcgggctt cagcgtcagc gagatcgagt tgatgcagta
    10381 ccgctggtcg gtcggggtgc cgtacccctc gccctcgaag acgtgcccga ggtgcgagcc
    10441 gcagttcttg cagcgcacct cgacccggcg catgccgagg ctggtgtcct ccaggtactc
    10501 caccgagtcg ccggccagcg gcgcgtagta cgacggccag ccgcagtgcg agtcgaactt
    10561 cgtctcgctg ctgaacagct cggcgccgca cgcccggcag gcgtagacgc cgaccgtctt
    10621 ggtgtcggtg tactcgccga cgaacggccg ctcggtgccg gcctcgcgga gcacgtggta
    10681 ctcctccggg gacagctggg cgcgccactc ggcgtcggac ttctggacct cgtagctcac
    10741 ggcagtctcc agctcgggac ggggacggac ggacacgtca gacagcaggt gcaacgtccg
    10801 ccagggcggc cagaatttcc ggccccaggt tggtgacgtc gcccgcgccc atggtcagca
    10861 ccaggtcgcc gggcgcggcc agcgcggcca gcaccgcggg cgcggccgcg aagtcgtgct
    10921 cggcccggac gtccgccccg gcccggcggg ccgcgtcgat gatcagctcg gcggtgacgc
    10981 ccgggatcgg gtcctcgcgc gccgggtaga tgtccagcac caccgaggcg tccgccagcg
    11041 ccagcgccag ccccatctcc tcggccagct gctgggtccg ggagaacagg tgcggctgga
    11101 acaccaccag cacccggccc gcccccgccg cctcccggat cgcctccagg tcggccgcca
    11161 tctcggtcgg gtggtgcgcg tacgagtcga tcacctgggt gccgcgcgcc tcgcccttca
    11221 gctgcagccg ccgccgcacc ccggtgtacg cgcccagcgc cttcgccagc ccctcc
//
