LOCUS       NC_016109              21002 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3829521
            Orig. end                         :: 3850523
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21002
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="21"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21002
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21002
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11002](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11002)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(120..1652)
                     /gene="radA"
                     /locus_tag="KSE_RS16910"
                     /old_locus_tag="KSE_34250"
     CDS             complement(120..1652)
                     /GO_function="GO:0003684 - damaged DNA binding [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="radA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136539.1"
                     /locus_tag="KSE_RS16910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34250"
                     /product="DNA repair protein RadA"
                     /protein_id="WP_014136539.1"
                     /transl_table=11
                     /translation="MAARTKTTAKPRPSYRCTECGAQLLKWVGRCPECNAWGTVEEHGA
                     VPVRTTAAGPVSAPARPIGQVDGQVATARSTGVPELDRVLGGGLVPGAVVLLAGEPGVG
                     KSTLLLDVAAKAASDRHRTLYVTGEESAGQVRLRADRIDAISDHLYLAAEQDLGAVLGH
                     IEAVNPSLLILDSVQTIASAELDGAPGGPAQVREVAGALIRASKDRGMATLLVGHVTKD
                     GQIAGPRLLEHLVDVVLSFEGDRHARLRLIRGVKNRYGATDEVGCFELHDEGIVGLADP
                     SGLFLTRRDKAVAGTCLTVTLEGKRPLVAEVQALMVDSQIPSPRRTTSGLESPRIAMIL
                     AVVERHGGVKLGKQDIYTATVGGVKLTEPSADLAIALAVASSSTDTPLPNNLVAIGEVG
                     LAGEVRRVTGVQRRLAEAHRLGFTHALVPPDPGKVPAGMKVVEVSDIGEALRAIPGRRP
                     RSKPKADAAPPARTPADPGAQALARARAQAPVPAYPEELMAGWEPVDSDELA"
     misc_feature    complement(1697..1710)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.7"
                     /tool="antismash"
     gene            1805..3580
                     /locus_tag="KSE_RS16915"
                     /old_locus_tag="KSE_34260"
     CDS             1805..3580
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040218.4"
                     /locus_tag="KSE_RS16915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34260"
                     /product="BACON domain-containing protein"
                     /protein_id="WP_014136540.1"
                     /transl_table=11
                     /translation="MTTGQPHPVDPTPALRAYGAHVDGLFTYCLSVLCEHEAASAAVLE
                     VRDLARRHGDRVDDPALLRAWLYALARHRCLARLEGDAADEDGAPGVPAPGALRERRRE
                     LASLAWPEAAGTDPEQREALELAVRHRLDGAEVAAVLGLSTADAAALLDAAGAEVGRTR
                     TALLVLGVGSCPELAQLGGVGAESWRGWVLGPALRRELVLHLVECPTCRGTAERVAGQL
                     GHGLAGLPGLPLLAAPGPLRPGVAPSGGAAFLTGAAAGRRAAQGPAEPRFDQRGFPRHR
                     MPSAPRGAAVRQRVVTTGVLAAVLAAPVVALWSAHRGGGEEHATAVSSVRVDPTAAPGR
                     RVPVPEPTAVGGAVGALPPAAPVQVLELAGAVAAETSLPTVQGPAVPVPSHGATPLSSP
                     ALSPEPAPPPTAADRDRLTVTAGAYGSRTVLTLTNSGDGPLAWHAVLDVDWLRLSRDGG
                     TLEPGQRITVTVTVDEARAPQSRWTARLALPPSTAVVTLEGGSDHRGVPTPDPAATGSP
                     APTPSASDSGPAEPSPSASASASVSASPPSSPPSSEPPPSSPPASPSPSASGPGSAGPS
                     PSVSASPSGAAAGSP"
     gene            complement(3588..5243)
                     /locus_tag="KSE_RS16920"
                     /old_locus_tag="KSE_34270"
     CDS             complement(3588..5243)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015103 - inorganic anion transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136541.1"
                     /locus_tag="KSE_RS16920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34270"
                     /product="SulP family inorganic anion transporter"
                     /protein_id="WP_014136541.1"
                     /transl_table=11
                     /translation="MGRPKPSDVTSGLVTGLFSIPEGMAYASIAGFNPVAGLFSGVVPA
                     IVGSLTARTVLMVTTLTSAIALTSQSVLGDAGLDPSDAGNVAMLGVLSGVVMLLMGVLR
                     LGVVLSFVSNAVMVGFSTGIALQIVVGVLKDATGYRPQGHNKLAQLGDWLVHAGSWELA
                     ATLVAVATVAVWVLAHAVKRLRTVALLVAMVLVSAGVAVFGTDVELVGGIADIPAALPH
                     FTAPDWSAAWHLLGGALSIALVALAQAAGISPSVPNPDGSKSSVNGDFTAQGLASATGA
                     LFQSLPVGGSLSRTGVAVSAGAGTRWAGVFSGVWLALIVLVLAPLAEHIPMPVIGGLII
                     VVGGELIVGKVPDVRLVLRTSRLSAAAMVVTFLGTTQLPLQQAIILGAVLSLLLYCVQA
                     ARQARLTALVPAGGGRWRIAEVPAELPAGQVTVLAYSGVSLFAELPLIESAWPKAPDGP
                     AVLVLVVRAVPDVPSSSMVKLLRRRNEELGARGGRLIVAGAQPSFVRLTEHTGLAGALG
                     ADGVVPADPVLDASLEEAVARGERWLAGERTAAD"
     gene            complement(5327..5995)
                     /locus_tag="KSE_RS16925"
                     /old_locus_tag="KSE_34280"
     CDS             complement(5327..5995)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136542.1"
                     /locus_tag="KSE_RS16925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34280"
                     /product="GAP family protein"
                     /protein_id="WP_014136542.1"
                     /transl_table=11
                     /translation="MGDAIGQMLASAVGIAISPLPLIAVILMLATPRGRSNGIAFTAGW
                     VVALGAVTTAVVLAGSGIDSSAGTPDWSYWVKLGLGVLFLLLAARQWRGRPRAGQTAEQ
                     PGWMRAIDRFGPPKSAGLAAVLVAANPKNLVLAVGGAVSIATSGASGGGKAVAGALLVL
                     IGSLCTLLPLGVYLLGGARATEVLGGWKAWMSAHNSAIMIVLLLVLGVKYVGDAVSGLA
                     "
     gene            complement(6032..7360)
                     /locus_tag="KSE_RS16930"
                     /old_locus_tag="KSE_34290"
     CDS             complement(6032..7360)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136543.1"
                     /locus_tag="KSE_RS16930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34290"
                     /product="DUF1254 domain-containing protein"
                     /protein_id="WP_014136543.1"
                     /transl_table=11
                     /translation="MADATPEMLAAEAHVYGSPLVAGLVAVDGIVRHGLGSIGPTPWNT
                     FGHAAELGDASSHFVSVNNDTLYSVAPLDLSAGPLLLHVPDTGGAYDVLQFVDAWTNNF
                     AYVGRRSSGTAEQSWLVAPPGWRGTAPEGVPVISSPTAVAVILGRNYCAGPDDIPRVRE
                     LQGQLTLTPVDGGAATGLPEPDPGVPGDLLFLERLRLWAAAFPPAAADVEFQRRFAPIG
                     LHDQGRSPYLDGPPEWAAALAKGLAAGRERVEAATAGADDATGEWAANLHLFDYNLDHL
                     GPGTRDEPQWKIADRRSAYLSRAVAARAGLWGNHAYEAAYATTYHDADGVELTGAHAYT
                     LRFERTPPVGAFWSVTMYGTPEYLLVANEIDRYSIGDRTPGLVYGEDGSLTLYLQRERP
                     TDAAEFANWLPAPEGGFRPMVRMYQPKDEVLDGSYRLPPIRLR"
     gene            complement(7388..8683)
                     /locus_tag="KSE_RS16935"
                     /old_locus_tag="KSE_34300"
     CDS             complement(7388..8683)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136544.1"
                     /locus_tag="KSE_RS16935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34300"
                     /product="DUF1254 domain-containing protein"
                     /protein_id="WP_106437959.1"
                     /transl_table=11
                     /translation="MGNPVGADPAAVRRTAARAWVWGYPLVENYRTIYPQAIDDADPRY
                     VGGFGVFRHYPRPFTPENTDVVTPNNDTPYSWAWLDLRAEPWVLEKPAADRYHVLPVHD
                     LDTAYVGFVGSRATGPGAGRYLVAGPGHRANPPEGFDGVLRADTNLVGIVGRTSSAGPA
                     DVPEVERIQAGYVLKPLSEHLGTPRPVAAEPLWPVWRGEEVLGTLEFFSLLDFLLGFFP
                     TLPADAELRGRLTELGIGSGDFEPAALPAEVRAALLAGIADGRAELVAATDGAATGTTL
                     FGTREQLGTRYLDRACGALKGLYGLPVEEAWYGGWESTAGGRERSVLRFPAGGLPPARF
                     FWSVSMYRLPERLLVANEIDRYSVGDRTPGLVYGEDGSLTLYLQHERPTDAAEFANWLP
                     APEGPYFVAVRAYGPKPELLDGSWQLPTLTAR"
     misc_feature    8713..8727
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.44"
                     /tool="antismash"
     gene            8928..9929
                     /locus_tag="KSE_RS16940"
                     /old_locus_tag="KSE_34310"
     CDS             8928..9929
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013530.5"
                     /locus_tag="KSE_RS16940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34310"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_014136545.1"
                     /transl_table=11
                     /translation="MDILLLGGSKFLGRAYATEALARGHRVTTFNRGVSRTDPPGVEAV
                     HGDRGNPADLERLVDGRTWDAVVDTSGQQPHDVATTARLLDGRAGHYGFVSSIHAFADW
                     PAHPVDADSATLDCPGDLPPDQPFANALKAGCERALTAHFTGPAAILNCGLLIGPHEPI
                     GRLPWWLDRIARGGRVLAPGHPDRPLSLIDARDFAAFGLDLAERRAAGRYVTTAPIRST
                     TTGEFLDACRTATGSDAELVWTPDADLLAADVSPWVELPLWAPATDGWHGTWQADPATA
                     LAAGLRTRPVLDTVTDTWAWLESGGRAEVSYRQLDTPLGIDPAKERRILDGR"
     gene            complement(10001..11002)
                     /locus_tag="KSE_RS16945"
                     /old_locus_tag="KSE_34320"
     CDS             complement(10001..11002)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578694.1"
                     /locus_tag="KSE_RS16945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34320"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_231873377.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.8e-62, bitscore:
                     208.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALLGRARTVVDPALRAAVDTLPDSMRLISGYHLGWLEADGAPSA
                     VGAGKSIRPAMVLAATTAVGGRPQDAVRAAAAVELVHNFTLLHDDVIDRDHTRRHRPTA
                     WRVFGTTGAILAGDAMHSLALRVLAEDPHPAAAAAVRRLADCVVELCAGQQADCSFEQR
                     TDVTLAECLTMAEGKTGALLGCACALGALYAGADAETADAMDAFGREIGLAFQLIDDLI
                     GIWGDPAVTGKPVGADLAARKKSLPVVHALSSGTPAGAELAALYATGRPLSPTELAAAA
                     DAVDRAGGRGWAQTESCDRMAAAIAHLAAAVPDPSGADDLLALAELVTRRTY"
     gene            complement(11484..12890)
                     /locus_tag="KSE_RS16950"
                     /old_locus_tag="KSE_34330"
     CDS             complement(11484..12890)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136547.1"
                     /locus_tag="KSE_RS16950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34330"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_014136547.1"
                     /transl_table=11
                     /translation="MTTETTAGIPQARQQSSLSVAAAKNLASTTKSAPQMQEISNRWLL
                     RALPWVEVSGGTYRVNRRLSYAVGRGRVSFAQTGRQVSVVPPTLREVPVLRGFEDDALL
                     AELAGRFVQRDFAVGDVLIEQGAEIDEVFLVAHGKVDKIGTGKYGDPTVLGTFADGDHI
                     GDEALTVADRRWPYSVKATTSGTVLVLAWPAFQELVDRSEALRDQILAFIADSQLPQTH
                     KGEAAIGMSAGHEGEFDLPTAFVDYELSPREYELSVAQTVLRVHSRVADLYNQPMDQTE
                     HQLRLTVEALRERQEHELVNNPEFGLLSNAEYGQRIQTHSGPPTPDDLDELLCRRRSTK
                     FYLAHPKAIAAFGRECNSRGLYPEAIQFEGKTVPSWRGVPILTCNKIPVVNGTTSILAM
                     RVGEDNQGVIGLRPGALPDQVEPGLNVRFMGIDEKAVVKYLVSAYYSAAVLVPDAIGVL
                     ENVDVAHWQH"
     gene            13339..14445
                     /locus_tag="KSE_RS16955"
                     /old_locus_tag="KSE_34340"
     CDS             13339..14445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136548.1"
                     /locus_tag="KSE_RS16955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34340"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_014136548.1"
                     /transl_table=11
                     /translation="MTAPVRVWLNRTYAENVFFIDLLRSAPRPVHILATHVDPDSPVLA
                     AADLGALEPDGLSAEAYVEFALAFCARHDVDVFLPRLHQLAISLRHRDFEALGTALVCP
                     PASAISLFASKSDGYRALDAAGLPTPLWRHADTAAELLAAVEEIEATGVPACLKPASGA
                     GGEGFRVLTREPFSLRRLAGYVDSRVQLDQVLAALEASPTPAELLVMPYLDGPEVSVDC
                     LAERDGRVLAAVGRTKQGRRRGFTVDPAYLEPARRLVEEFGVGHLSNVQFRHERHTGRP
                     VVLDINTRPSGGLHQLRVCGLNLPAAALELALGGRPVLPATDELTLGEYTLVSTIQALL
                     PRQSAAPALERIESVAVGTGAELLSTAG"
     misc_feature    13381..13392
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 14.77"
                     /tool="antismash"
     misc_feature    13382..13396
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.86"
                     /tool="antismash"
     gene            complement(14526..15074)
                     /locus_tag="KSE_RS16960"
                     /old_locus_tag="KSE_34350"
     CDS             complement(14526..15074)
                     /EC_number="2.1.1.63"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003908 -
                     methylated-DNA-[protein]-cysteine S-methyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136549.1"
                     /locus_tag="KSE_RS16960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34350"
                     /product="methylated-DNA--[protein]-cysteine
                     S-methyltransferase"
                     /protein_id="WP_014136549.1"
                     /transl_table=11
                     /translation="MDLSWVTVPTPLPSGPMRFGVTARGVASASYTGSYPGAAGPECTD
                     PRRVELVRARVGEYFAGVRRELELPIDWSLAGGPHLVVLRCLLATVGWGRTVTYGELAA
                     RSGVFTDPSEPGVPARTVGQMMGANPLPLLVPCHRVVAADGLGGFGGAWHGVETKRWLL
                     TLEGVLPPTLDWSGPTEAG"
     gene            complement(15174..15398)
                     /locus_tag="KSE_RS16965"
                     /old_locus_tag="KSE_34360"
     CDS             complement(15174..15398)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS16965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_34360"
                     /product="hypothetical protein"
                     /protein_id="WP_014136550.1"
                     /transl_table=11
                     /translation="MPGSMTIGHTDTLVMLSHDDAEHLSAVLAGLSALAASGRLSTEQL
                     AALGAGEAPDRAALATWSRTLAGYLRDHL"
     gene            15623..16990
                     /locus_tag="KSE_RS16970"
                     /old_locus_tag="KSE_34370"
     CDS             15623..16990
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005247 - voltage-gated chloride channel
                     activity [Evidence IEA]"
                     /GO_process="GO:0006821 - chloride transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136551.1"
                     /locus_tag="KSE_RS16970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_34370"
                     /product="chloride channel protein"
                     /protein_id="WP_014136551.1"
                     /transl_table=11
                     /translation="MPAEAAGPSQPPGLRELLRSPGYGRLLLVSALVGVPVSLAAFGFV
                     SLEHELQHWVWESLPDQLGYDRAPWWWPLPALALAGLLLAPIVTRMPGRGGHTPVLGLG
                     GPPTLPVEVPSVVLAALASLPLGAVLGPEAPLMALGSGLALLTVSAAKRANSPMVGPML
                     GAAGSTAAIATIFGSPLVAAVMMIEAAGLGGAQLTLLLLPCLLSSGVGALVFTGFGHWT
                     GLSIGSLNLPSVPKAQLPDAGDFLWGVPLAMAIAVILVAGQTLGHRFAAFTAHRTAVRT
                     VLSAVLVGACIAGYALVTGRSPEEAALSGQAALGQLAADPRSWSVGALLALVLFKGLGW
                     GVALGSLRGGPIFPAVLLGAALGVAAGGLPGLGVEAGLAAGLAASGAAVMRLPVTSTVL
                     AAALLGDQSADSMPLLIVSAVVSFLTATFVHRVAAPRPTAEGDGGGEGRGRGRVAA"
     gene            complement(17162..17515)
                     /locus_tag="KSE_RS42170"
                     /old_locus_tag="KSE_34380"
     CDS             complement(17162..17515)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS42170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_34380"
                     /product="hypothetical protein"
                     /protein_id="WP_014136552.1"
                     /transl_table=11
                     /translation="MFEAGFVLAGTVLPLSLVHRWGRNVPHPVPLLGGRPVPRWLPLGP
                     AAALSVGLLVYFGVGIAQLLGETLHPASRDDTLPLPFLWIAMPAYWLWGLGLGAAALGY
                     ARATRPPCRACGR"
     misc_feature    18631..18648
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     misc_feature    complement(18757..18774)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.11"
                     /tool="antismash"
     misc_feature    complement(18768..18785)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.36"
                     /tool="antismash"
     misc_feature    18958..18973
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    18982..18996
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     misc_feature    20278..20293
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 18.98"
                     /tool="antismash"
     misc_feature    20608..20623
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.48"
                     /tool="antismash"
     misc_feature    20608..20623
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.33"
                     /tool="antismash"
     misc_feature    complement(20833..20848)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.32"
                     /tool="antismash"
ORIGIN
        1 tccttgggcc gacccgaacc gtgtgccgcg gcggccgacg gtctgtctct cgttgttcct
       61 gcgcatgatg ccgatgagca gctgaagtct aactgcgtac ggccgcgacg gggcgtgggt
      121 caggccagtt cgtccgagtc gaccggctcc caacccgcca tcagctcctc cggataggcc
      181 gggaccgggg cctgggcgcg ggcccgggcg agcgcctggg cgcccgggtc ggcgggcgtg
      241 cgggcgggcg gcgcggcgtc cgccttcggc ttcgagcggg ggcggcggcc cgggatcgcg
      301 cgcagcgcct cgccgatgtc ggagacctcc accaccttca tgccggccgg gaccttgccc
      361 gggtccggcg ggacgagcgc gtgggtgaag cccagccggt gcgcctccgc cagccgccgc
      421 tgcacgccgg tcacccgccg cacctcgccc gccaggccga cctcgccgat cgccaccagg
      481 ttgttcggca gcggcgtgtc ggtcgaggac gaggccaccg ccagggcgat cgccaggtcg
      541 gccgacggct cggtgagctt cacgccgccg accgtcgccg tgtagatgtc ctgcttgccg
      601 agcttcacgc cgccgtgccg ctccaccacc gccaggatca tcgcgatccg cggcgactcc
      661 aggcccgagg tggtgcgccg cggcgagggg atctgcgagt ccaccatcag cgcctgcacc
      721 tcggccacca gcgggcgctt gccctccagc gtgacggtca ggcaggtgcc ggcgacggcc
      781 ttgtcgcggc gggtcaggaa caggccggac gggtcggcca ggccgacgat gccctcgtcg
      841 tgcagctcga agcagccgac ctcgtcggtc gcgccgtacc ggttcttcac gccgcggatc
      901 agccgcagcc gggcgtgccg gtcgccctcg aaggagagca ccacgtccac caggtgctcc
      961 agcaggcggg ggccggcgat ctggccgtcc ttggtgacgt ggccgaccag cagggtggcc
     1021 atgccgcggt ccttggaggc ccggatcagc gcgcccgcca cctcgcggac ctgcgccggg
     1081 ccgcccgggg cgccgtccag ctcggcggac gcgatggtct gcaccgagtc caggatcagc
     1141 agcgaggggt tgaccgcctc gatgtggccg agcaccgcgc ccaggtcctg ctcggcggcc
     1201 aggtagaggt ggtcggagat cgcgtcgatc cggtccgcgc gcagccggac ctggccggcc
     1261 gactcctcgc cggtgacgta cagcgtgcgg tgccggtcgc tggcggcctt ggccgcgacg
     1321 tccagcagca gggtcgactt gccgacgccg ggctcgcccg ccagcagcac caccgcgccc
     1381 ggcaccaggc cgccgccgag cacccggtcc agctccggga cgccggtcga gcgggccgtc
     1441 gccacctgcc cgtcgacctg cccgatcggc cgggcgggcg ccgagaccgg ccccgccgcc
     1501 gtcgtccgga ccgggacggc gccgtgctcc tccaccgtgc cccaggcgtt gcactcgggg
     1561 cagcggccga cccacttcag cagttgggcg ccgcactcgg tgcagcggta cgaggggcgc
     1621 ggcttcgcgg tggtcttggt acgggcagcc atgcgggcca cggtagcgcc tcgcaccgac
     1681 aacgcccgga cctcactcga acggcgtcaa ccaggcgaac aaggaatcgg tcctgttacc
     1741 cgaaagaagg acaaacgggg gaaaccttcc gggcggcggg tttcggctgc ctaccgtcgg
     1801 ttccgtgacc accggccagc cccaccccgt cgacccgacc ccggcactcc gggcgtacgg
     1861 cgcgcacgtc gacgggctgt tcacctactg cctgtccgtg ctctgcgagc acgaagccgc
     1921 cagcgcggcc gtcctggaag tccgcgacct cgcccggcgg cacggcgacc gggtcgacga
     1981 cccggcgctg ctgcgcgcct ggctgtacgc gctggcccgg caccgctgcc tggcccgcct
     2041 cgaaggggac gccgccgacg aggacggcgc ccccggcgtc ccggcgcccg gcgcgctgcg
     2101 cgagcggcgg cgcgaactcg cctcgctggc ctggcccgag gcggccggca ccgaccccga
     2161 acagcgcgag gcgctggaac tcgcggtccg ccaccggctg gacggcgcgg aggtcgccgc
     2221 ggtgctcggc ctgagcaccg cggacgccgc cgccctgctg gacgccgccg gcgccgaggt
     2281 cggccggacc aggaccgcgc tgctcgtcct cggcgtcggt tcctgccccg aactcgccca
     2341 gctcggcggc gtcggcgcgg agtcctggcg gggctgggtg ctcggcccgg cgctgcgccg
     2401 cgaactcgtc ctgcacctgg tcgagtgccc cacctgccgg ggcaccgccg aacgggtcgc
     2461 cggccagctc ggccacggcc tcgccgggct gcccggcctg ccgctgctgg ccgcgcccgg
     2521 gccgctgcgc cccggcgtgg cgccgtccgg cggggcggcc ttcctgaccg gcgcggccgc
     2581 gggccggcgg gccgcgcagg gccccgccga accccggttc gaccagcgcg gcttcccccg
     2641 gcaccggatg ccctcggcac cgcgcggcgc cgcggtccgg cagcgggtgg tgaccaccgg
     2701 cgtgctggcc gcggtgctgg ccgcgccggt ggtcgcgctg tggagcgcgc accggggcgg
     2761 cggcgaggag cacgccaccg cggtctcctc ggtgcgggtc gacccgacgg cggcgcccgg
     2821 gcggcgggtg ccggtgcccg agccgaccgc ggtcgggggc gcggtcggcg cgctgccgcc
     2881 ggccgccccg gtgcaggtgc tggagctggc cggcgcggtg gccgcagaaa cgtccctgcc
     2941 gaccgttcag ggcccggcgg tgccggtgcc ctcgcacggc gccaccccgc tctccagccc
     3001 cgcgctgagc cccgagcccg ccccgccgcc gaccgccgcc gaccgggacc ggctgaccgt
     3061 gacggccggc gcgtacggca gccgcaccgt gctgaccctc accaactccg gtgacgggcc
     3121 gctggcctgg cacgccgtgc tggacgtcga ctggctgcgg ctgagccggg acggcggcac
     3181 cctggagccc ggccagcgga tcaccgtcac cgtcaccgtc gacgaggcgc gcgccccgca
     3241 gtcccgctgg accgcgcgcc tggcgctgcc gccgtccacc gccgtggtga ccctggaggg
     3301 cggcagcgac caccgcggcg tccccacccc ggacccggcg gcgaccggga gcccggcgcc
     3361 cacgccgtcc gcgagcgact ccggaccggc cgagccctcg ccgtccgcct ccgcctccgc
     3421 ctcggtctcc gcgtcgccgc cgtcgtcgcc gccctcgtcg gagcccccgc cgtcgtcacc
     3481 cccggcctcg ccctcgccgt cggcctcggg cccgggctcg gccggtccgt ccccgtccgt
     3541 ctccgccagc ccgtccggcg cggccgccgg ctcgccgtga cgggtggtca gtccgccgcg
     3601 gtgcgctcgc cggccagcca gcgctcaccg cgggccaccg cctcctccag cgaggcgtcc
     3661 aggacggggt cggcgggaac gactccgtcc gcgccgagcg cgccggccag cccggtgtgc
     3721 tcggtgagcc ggacgaagga gggctgcgcc ccggcgacga tcagccgtcc gccgcgggcg
     3781 cccagctcct cgttcctccg gcgcagcagc ttgaccatgc tggacgaggg cacgtcgggg
     3841 acggcccgca ccaccagcac cagcaccgcc gggccgtccg gcgccttcgg ccaggccgac
     3901 tcgatcagcg gcagctccgc gaacaggctg acaccgctgt aggccagcac ggtgacctgc
     3961 ccggcgggca gttcggcggg cacctcggcg atccgccagc ggccgccgcc ggccgggacg
     4021 agcgcggtca gccgggcctg ccgggcggcc tgcacgcagt agagcagcag cgagagcacc
     4081 gcgccgagga tgatcgcctg ctgcagcggc agctgggtgg tgcccaggaa ggtgaccacc
     4141 atcgcggcgg cggacagccg cgaggtccgc agcaccagcc ggacgtccgg gaccttgccg
     4201 acgatcagct cgccgccgac cacgatgatc agcccgccga tcaccggcat cgggatgtgc
     4261 tcggcgagcg gcgccaggac cagcacgatc agcgccagcc agacgccgga gaacacgccc
     4321 gcccagcggg tcccggcccc ggccgagacc gcgacgccgg tgcgcgacag cgagccgccg
     4381 accggcagcg actggaacag cgcgccggtg gcactggcca ggccctgcgc ggtgaagtcg
     4441 ccgttgacgc tggacttcga gccgtccggg ttgggcaccg acgggctgat cccggccgcc
     4501 tgggcgagcg ccaccagcgc gatcgacagc gccccgccga gcaggtgcca ggccgccgac
     4561 cagtcgggcg cggtgaagtg cggcagcgcg gccgggatgt cggcgatgcc gccgaccagc
     4621 tccacgtccg tgccgaacac tgccacgccc gcgctgacca gcaccatcgc caccagcagc
     4681 gccaccgtcc ggagccgctt caccgcgtgc gccagcaccc acaccgcgac ggtcgccacc
     4741 gcgaccagcg tcgccgcgag ctcccaggaa ccggcgtgca ccagccagtc gccgagctgc
     4801 gccagcttgt tgtggccctg cggccggtac ccggtggcgt ccttgagcac gccgaccacg
     4861 atctgcagcg cgatgccggt cgagaagccg accatcaccg cgttcgacac gaagctcagc
     4921 accaccccga gccgcagcac gcccatcagc agcatcacca cgccggacag cacgcccagc
     4981 atcgccacgt tcccggcgtc ggacgggtcg agcccggcgt cgcccagcac gctctgcgag
     5041 gtcagcgcga tggcgctggt cagcgtggtg accatcagca cggtacgggc ggtcagcgag
     5101 ccgacgatcg ccgggacgac gccggagaac aggcccgcga ccgggttgaa gccggcgatc
     5161 gacgcgtacg ccatgccctc cgggatcgag aacaggccgg tgaccagccc ggaggtgacg
     5221 tcgctcggct tcgggcggcc caacgaacga cccagcgacc ggcccagcga ccggccccgg
     5281 ccttgcaacg acggccgccc ccggccgggc ggcgccggcc ggcccatcag gccagccccg
     5341 acacggcgtc gccgacgtac ttcacgccca ggaccagcag cagcacgatc atgatcgccg
     5401 agttgtgcgc ggacatccac gccttccagc cgcccagcac ctcggtcgcc cgcgccccgc
     5461 ccagcaggta gacgcccagc ggcagcagcg tgcacagcga gccgatcagc accagcagcg
     5521 ccccggcgac cgccttgccg ccgccgctcg cgccgctggt ggcgatcgag accgcgccgc
     5581 cgaccgccag caccaggttc ttcgggttgg cggcgaccag caccgccgcc aaccccgccg
     5641 acttcggcgg gccgaaccgg tcgatcgccc gcatccagcc gggctgctca gcggtctgcc
     5701 ccgcgcgcgg ccgcccccgc cactgccgag ccgccagcag caggaacagc acgcccagcc
     5761 cgagcttcac ccagtacgac cagtccggcg tccccgcgct gctgtcgatg cccgaaccgg
     5821 ccagcaccac cgcggtggtg accgcgccca gcgccaccac ccagcccgcc gtgaacgcga
     5881 tgccgttgga ccgcccgcgc ggggtggcca gcatcaggat caccgcgatc agcggcagcg
     5941 gactgatcgc gatgccgacc gccgaggcca gcatctgccc gatcgcgtca cccatccccg
     6001 ttcccgcctc tcctcgggtt cgcccttccg gtcagcgcag ccggatcggg ggcagccggt
     6061 aactcccgtc cagcacctcg tccttcggct ggtacatccg caccatcggc cggaagccgc
     6121 cctccggcgc gggcagccag ttcgcgaact cggcggcgtc ggtgggccgt tcgcgctgga
     6181 ggtagagcgt cagcgagccg tcctcgccgt acaccaggcc gggcgtgcgg tcgccgatcg
     6241 agtaccggtc gatctcgttg gcgaccagca ggtactccgg ggtgccgtac atcgtcaccg
     6301 accagaacgc gcccaccggc ggggtccgct cgaaccgcag ggtgtacgcg tgcgcgccgg
     6361 tcagctcgac gccgtccgcg tcgtggtagg tggtggcgta cgcggcctcg taggcgtggt
     6421 tgccccacag gccggcccgg gcggccaccg cgcgggacag gtaggcggag cggcggtcgg
     6481 cgatcttcca ctgcggctcg tcgcgggtgc cggggccgag gtggtccagg ttgtagtcga
     6541 acaggtgcag gttcgcggcc cactcgccgg tggcgtcgtc ggcgccggcg gtcgccgcct
     6601 ccacccgctc ccggcccgcc gccagaccct tggccagcgc cgccgcccac tccggcgggc
     6661 cgtccaggta cggcgagcgg ccctggtcgt gcaggccgat cggggcgaag cggcgctgga
     6721 actccacgtc ggcggcggcg ggcgggaacg cggccgccca gagccgcagc cgctccagga
     6781 acagcaggtc cccggggacg cccgggtcgg gctccgggag gcccgtcgcg gcgcccccgt
     6841 ccaccggggt gagcgtcaac tgcccctgga gttcgcgcac tcggggaatg tcgtccggcc
     6901 cggcgcagta gttgcgcccg aggatcacgg cgaccgccgt cggcgagctg atcaccggca
     6961 cgccctccgg cgccgtcccg cgccaaccgg gcggggccac cagccaggac tgctcggcgg
     7021 taccggacga acgacggccc acgtaggcga agttgttcgt ccaggcgtcg acgaactgca
     7081 gcacgtcgta cgcgccgccg gtgtccggga cgtgcagcag cagcgggccg gccgacaggt
     7141 ccagcggggc gaccgagtac agcgtgtcgt tgttcaccga cacgaagtgc gaggaggcgt
     7201 cgccgagttc ggcggcatgg ccgaaggtgt tccacggcgt cggaccgatc gagcccagcc
     7261 cgtggcggac gatgccgtcc accgcgacca agcccgccac cagcggggag ccgtacacgt
     7321 gggcctcggc ggccagcatt tcgggtgtgg cgtcagccat ccgaacgtcc ttgtctgatc
     7381 gggtacttca gcgggcggtg agggtgggga gctgccaact tccgtccagc agctcgggct
     7441 tcggaccgta ggcgcgcacc gcgacgaagt acgggccctc gggagcgggc agccagttcg
     7501 cgaactcggc ggcgtcggtg ggccgttcgt gctggaggta gagcgtcagc gagccgtcct
     7561 cgccgtacac caggccgggc gtgcggtcgc cgaccgagta ccggtcgatc tcgttggcga
     7621 ccagcagccg ctccggcagg cggtacatcg acaccgacca gaagaaccgg gccggcggga
     7681 ggccgccggc cgggaagcgc agcacggacc gctcccggcc gcccgccgtc gactcccaac
     7741 cgccgtacca ggcctcctcg accggcagcc cgtacaggcc cttgagggcg ccgcaggccc
     7801 ggtccaggta gcgggtgccc agctgctccc gggtgccgaa gagggtggtg ccggtggccg
     7861 cgccgtccgt cgccgcgacc agctccgccc ggccgtccgc gatgcccgcg agcagcgccg
     7921 cacgcacctc ggcgggcagc gccgccggct cgaagtcacc gctgccgatg cccagttcgg
     7981 tcagtcggcc gcgcagctcg gcatccgcgg gcagggtcgg gaagaagccc agcaggaagt
     8041 ccagcaggga gaagaactcc agcgtgccga gcacctcctc gccccgccag accggccaga
     8101 gcggctcggc ggcgaccggg cgcggcgtgc ccaggtgctc gctcagcggc ttcagcacgt
     8161 acccggcctg gatccgctcg acctccggca cgtcggcggg ccccgccgag gacgtccgtc
     8221 cgacgatccc gaccaggttg gtgtcggccc gcagcacccc gtcgaagccc tccggcgggt
     8281 tcgcccggtg ccccgggccc gcgaccaggt agcggcccgc gccgggcccg gtggcgcgtg
     8341 agccgacgaa gccgacgtac gcggtgtcca ggtcgtgcac cggcagcacg tggtagcggt
     8401 cggcggcggg cttctccagc acccacggct cggcccgcag gtccagccac gcccacgagt
     8461 acggggtgtc gttgttgggc gtcaccacgt ccgtgttctc cggggtgaac ggccgcgggt
     8521 agtgccggaa cacgccgaac cccccgacgt accgggggtc cgcgtcgtcg atcgcctgcg
     8581 ggtagatcgt ccggtagttc tccaccagcg ggtaccccca gacccacgcc cgcgccgccg
     8641 tccgccgcac cgccgccgga tccgcgccga ccgggttgcc catctcgccc acccttctcc
     8701 cccacaaaag ggaatatcca gacatagcgg tacacccgga tgctatgtgc tcccttttcg
     8761 atcggcactc cggcggcatc ggcactccgg cggcgaggac ggacggggac cgggcgcgcg
     8821 gccggcggtc tgccggtggt ctgccggtgg tctgccggcg gcagaaccgc tccgccgccg
     8881 gtgaacacgg cgcatggacg gccccggcgg cggagaccct cgaaggcatg gacatccttc
     8941 tgctcggcgg atccaagttc ctcggccgcg cctacgccac cgaggccctc gcccgcggcc
     9001 accgcgtcac caccttcaac cgcggcgtca gccgcaccga cccgcccggc gtcgaggccg
     9061 tccacggcga ccgcggcaac cccgccgacc tggagcgcct cgtcgacggc cggacctggg
     9121 acgccgtcgt cgacacctcg gggcagcagc cccacgacgt cgccaccacc gcccggctgc
     9181 tcgacggccg cgccgggcac tacggcttcg tctcctcgat ccacgccttc gccgactggc
     9241 ccgcccaccc cgtcgacgcc gactccgcca ccctcgactg ccccggcgac ctcccgcccg
     9301 accagccctt cgccaatgcg ctcaaggccg gctgcgaacg cgccctgacc gcgcacttca
     9361 ccggacccgc cgcgatcctc aactgcggcc tgctgatcgg cccgcacgaa cccatcggcc
     9421 gcctcccctg gtggctcgac cggatcgccc gcggcggccg cgtcctcgcc cccggccacc
     9481 ccgaccgccc gctcagcctc atcgacgccc gcgacttcgc cgcgttcggc ctcgacctcg
     9541 ccgaacggcg ggccgccgga cgctacgtca ccaccgcgcc gatccgctcc accaccaccg
     9601 gcgagttcct cgacgcctgc cgcaccgcga ccggctccga cgccgaactc gtctggaccc
     9661 cggacgccga cctgctcgcc gccgacgtct ccccctgggt cgaactcccg ctctgggccc
     9721 ccgccaccga cggctggcac ggcacctggc aggccgaccc cgccaccgcc ctcgccgccg
     9781 gcctccggac ccgcccggtc ctcgacaccg tcaccgacac ctgggcctgg ctcgaatccg
     9841 gcggccgcgc cgaggtcagc taccggcagc tcgacacacc gctcggcatc gacccggcga
     9901 aggaacggcg gatcctcgac gggcggtagg cgggccgggc gtcccggccg gtacgtccgg
     9961 ctggtgcgtc cggctggtgc gtccggccgg tggcgtccgg ttagtacgtc cggcgggtga
    10021 cgagttcggc gagggccagc aggtcgtcgg cgccggacgg gtccgggacg gccgcggcga
    10081 ggtgggcgat ggcggcggcc atccggtcgc agctctcggt ctgggcccag ccgcggccgc
    10141 ccgcgcggtc gaccgcgtcg gcggcggcgg cgagttcggt ggggctgagc gggcggccgg
    10201 tggcgtacag cgcggcgagc tccgcgccgg ccggggtgcc ggaggagagg gcgtggacga
    10261 ccgggaggga cttcttgcgg gcggccaggt cggcgccgac cggcttgccg gtgaccgcgg
    10321 gatcgcccca gatgccgatc aggtcgtcga tcagctggaa ggccagtccg atctcgcggc
    10381 cgaaggcgtc catcgcgtcg gcggtctccg cgtccgcccc cgcgtacagc gcgccgagcg
    10441 cgcacgcgca gccgagcagg gcgccggtct tgccctcggc catggtcagg cactcggcga
    10501 gggtgacgtc ggtgcgctgc tcgaaggagc agtcggcctg ctggcccgcg cacagctcga
    10561 ccacgcagtc ggcgaggcgg cggacggccg cggcggccgc cgggtgcggg tcctcggcga
    10621 gcacccgcag ggccagcgag tgcatggcgt cgccggccag gatcgcgccc gtggtgccga
    10681 acacccgcca ggcggtgggc cggtggcggc gggtgtggtc gcggtcgatg acgtcgtcgt
    10741 gcagcagcgt gaagttgtgc accagctcga cggcggccgc ggcccggacc gcgtcctgcg
    10801 gacggccgcc gaccgcggtg gtcgcggcca gcaccatcgc cgggcggatc gacttgcccg
    10861 cgccgaccgc gctcggggcg ccgtccgcct ccagccagcc caggtggtag ccggagatca
    10921 gccgcatcga gtccgggagg gtgtcgaccg ccgcccgcag cgccgggtcg acgacggtac
    10981 gggcccggcc gagcagggcc atcgcctcgg cggtgtcgcg cccgccgtcg acggccgcga
    11041 ccgtcgcgtt ctcgccgtgc tgcccgcgtt cgggcacggt gatggccatg gtggatcctc
    11101 cccctcgacg gccccggctg cggggcggcg tgaatgtgcg ctgacggtcc gccaggcggt
    11161 gcagcggtga agcggacggg ccgtcgggcg cggtgcgcgg gctgacgggc gcggtgcgcg
    11221 ggctgacagg cgcggcgcgc gggctgacag gcgcggcgcg cgggctgaca ggcgcggcgc
    11281 gcgggctgac aggcgcggcg cgcgggctga cgggcgcggc ccgggcgggc cggcggatga
    11341 ctcccctacg gccggccgac ccgcccgggc ggcgggacgt gcggtggaac gtgcggtgga
    11401 acggcgacac cggccggtac cggaacggac gagcaccgga acggacggac gggcgggccc
    11461 aggacggtgg gcccgcccgg tggtcagtgc tgccagtggg cgacgtccac gttctccagg
    11521 acgccgatcg cgtcgggaac gaggaccgcc gccgagtagt aggcgctgac caggtacttg
    11581 accacggcct tctcgtcgat gcccatgaag cggacgttca ggccgggctc gacctggtcc
    11641 gggagcgcgc cggggcgcag gccgatcacg ccctggttgt cctcgccgac gcgcatcgcc
    11701 aggatcgagg tggtgccgtt gaccaccggg atcttgttgc aggtcaggat cgggacgccg
    11761 cgccagctcg gcaccgtctt gccctcgaac tggatcgcct ccgggtacag cccgcggctg
    11821 ttgcactccc ggccgaaggc ggcgatcgcc ttcgggtggg ccaggtagaa cttggtgctg
    11881 cggcggcggc agagcagctc gtccaggtcg tccggggtgg gcgggccgga gtgggtctgg
    11941 atccgctgcc cgtactcggc gttgctgagc aggccgaact ccgggttgtt gaccagctcg
    12001 tgctcctgcc gctcgcgcag cgcctcgacg gtcagccgga gctggtgctc ggtctggtcc
    12061 atcggctggt tgtagaggtc ggcgacccgg ctgtgcaccc gcagcaccgt ctgcgcgacg
    12121 ctcaactcgt actcgcgcgg cgagagttcg tagtcgacga aggccgtcgg caggtcgaac
    12181 tcgccctcgt ggccggccga catcccgatc gccgcctcgc ccttgtgggt ctgcgggagc
    12241 tgcgagtcgg cgatgaaggc gaggatctgg tcgcgcagcg cctcggagcg gtcgaccagc
    12301 tcctggaagg ccggccaggc cagcaccagc acggtgcccg aggtggtcgc cttcacgctg
    12361 tagggccagc ggcggtcggc gacggtgagc gcctcgtcgc cgatgtggtc gccgtccgcg
    12421 aaggtgccga gcacggtcgg gtcgccgtac ttgccggtgc cgatcttgtc gaccttgccg
    12481 tgcgcgacca ggaacacctc gtcgatctcg gcgccctgct cgatcagcac gtcgccgacg
    12541 gcgaagtcgc gctggacgaa gcggccggcc agctcggcca gcagcgcgtc gtcctcgaac
    12601 ccgcgcagca ccgggacctc gcgcagcgtc ggcgggacga cgctgacctg gcgaccggtc
    12661 tgcgcgaagc tcacccggcc ccggccgacc gcgtacgaga ggcgccggtt gacccggtag
    12721 gtgccgcccg agacctcgac ccagggcagc gcgcggagca gccagcgatt gctgatctcc
    12781 tgcatctgcg gggccgactt ggtggtcgac gcgaggttct tggcggccgc caccgagagg
    12841 ctgctctgct gcctcgcttg ggggattccg gcggtcgttt cggtcgtcat ttcggcgggg
    12901 cccctgatcg tgtcgacggc acgttgcggc aaccatgctg acggccgttc aggtgaggcg
    12961 gcaatcactc gtgggggtga ttcaggtgcg tgcgcgcaat agtgcgacca gcggactgga
    13021 gcgatcatcg tccgattcac gccccctccc ggcgggccgc cggacgtctc cggacacctc
    13081 cggacgcctc cgcgcggtgc cccgcgaagg gcctcgcgag gggcccgtcg gggccgctcc
    13141 gaagggtcgc cgagaggctt gtcgggaccc cttcaggacc ccctcgtttc ggacgtccgc
    13201 gcagctcacc caccccctgt tcgaatccct gcggaacagc gctatggtgg ccccctcacc
    13261 gcgtggtgac cgccgccgca gcgcaggcga accggtcggt gacctcccat cggcacgccc
    13321 ttctccaggg agaccctcgt gaccgcgccc gtccgcgtct ggctgaaccg cacctacgcc
    13381 gagaacgtct tcttcatcga tctgctgcgc tccgcgccgc gccccgttca catcctggcc
    13441 acccacgtcg accccgactc ccccgtgctc gccgccgccg acctgggtgc cctggaaccc
    13501 gacggcctct cggccgaggc gtacgtcgaa ttcgcgctcg ccttctgcgc ccgccacgac
    13561 gtggacgtct tcctgccccg cctgcaccaa ctcgcgatct cgctgcgcca ccgcgacttc
    13621 gaggcgctcg gcaccgccct ggtctgcccg cccgcctcgg cgatctcgct gttcgccagc
    13681 aagagcgacg gctaccgggc gctggacgcc gccggactgc ccaccccgct gtggcggcac
    13741 gccgacaccg cggccgaact gctcgccgcc gtcgaggaga tcgaggcgac cggcgtcccg
    13801 gcctgcctca agccggcctc cggcgcgggc ggcgagggat tccgcgtcct gacccgcgag
    13861 ccgttcagcc tccgccggct cgccgggtac gtcgactccc gggtccaact cgaccaggtg
    13921 ctggccgcgt tggaggcatc gccgaccccc gccgaactgc tggtgatgcc ctacctggac
    13981 ggccccgagg tctcggtcga ctgcctcgcc gaacgcgacg gacgggtact ggccgcggtc
    14041 ggccgcacca agcagggccg ccgccgcggc ttcaccgtcg accccgccta cctggagccg
    14101 gcccgccgcc tggtcgagga gttcggcgtc ggccacctgt ccaacgtcca gttccggcac
    14161 gagcggcaca ccggccgccc ggtcgtcctc gacatcaaca cccgcccgtc cggcggcctg
    14221 caccagctcc gggtgtgcgg actcaacctg cccgccgccg cgctcgaact cgccctcggc
    14281 ggacggcccg tgctccccgc gacggacgaa ctcacgctcg gcgagtacac cttggtctcc
    14341 accatccagg cgctactgcc ccggcagtcc gcggcgcccg cgctggagcg gatcgagagc
    14401 gtcgccgtcg gcaccggcgc ggaactcctc tccaccgcag gctagttgcg attgctgccg
    14461 tcggccctgg actggccgtc cctcgccctg gcgagccggc cgtttccggt cggccctcgc
    14521 cctggctagc cggcctccgt cggacccgac cagtcgaggg tcggcggcag tacgccctcc
    14581 agcgtgagca gccagcgctt cgtctccacc ccgtgccacg ccccgccgaa accgcccaac
    14641 ccgtccgccg ccaccacccg gtggcacggc accagcagcg gcagcgggtt cgcgcccatc
    14701 atctgcccca ccgtccgggc cggtaccccc ggctcggacg ggtcggtgaa caccccgctg
    14761 cgggcggcga gttcaccgta ggtgacggtc cggccccagc cgaccgtcgc caacaggcag
    14821 cgcagcacca ccaggtgcgg accaccggcc agcgaccagt cgatcggcag ctccaactcc
    14881 cgccgcacgc ccgcgaagta ctcacccacc cgggcccgca ccagctccac ccgccgcgga
    14941 tccgtgcact cgggcccggc cgcccccggg tagctgcccg tgtagctggc ggacgccacg
    15001 ccccgggcgg tcaccccgaa ccgcatcggc ccgctcggca agggggtcgg gacggtcacc
    15061 caggagaggt ccatccctcc actctaagga ctccgccgca gggaccccgg gggttcggcg
    15121 agaacggcgg agaacccccg gggcacaccg cccggggctc cggacgccgg gccctacagg
    15181 tggtcgcgga ggtagccggc cagggtgcgg gaccaggtgg ccagggcggc gcggtccggg
    15241 gcctcgcccg caccgagcgc ggcgagctgc tcggtggaga ggcggccgct cgcggccagc
    15301 gcggagaggc ccgcgaggac ggccgagagg tgttcggcgt cgtcgtggct gagcatcacg
    15361 agggtgtcgg tgtggccgat ggtcatggag ccgggcatct cgtcctcctc ggtcggtcct
    15421 cgatcggtcc tccgtccacc gtacgaccgc cggagccggg tcgcgcgggg tcgcgtgggg
    15481 tcgtgtgtgg tgggagtgga gggagggggc gggtctgcga ggggcggggg cggctcgccc
    15541 gttcggacca cccggatggc cgggggcggg gcgcccggcg gacggtcagg ggacggtgtc
    15601 cgacgggtga cagggagcgc agatgccagc agaggccgcc ggtccgtccc aaccgcccgg
    15661 tctgcgggag ctgctgcgca gccccggcta cgggcggttg ctgctggtgt cggcgctggt
    15721 cggggtgccg gtctcgctgg cggcgttcgg cttcgtgagc ctggagcacg agctgcagca
    15781 ctgggtgtgg gagtcgctgc cggaccagct cggctacgac cgggcaccct ggtggtggcc
    15841 gctgcccgcg ctggccttgg ccggtctgct gctggccccg atcgtgaccc ggatgcccgg
    15901 ccggggcgga cacacccccg tcctcgggct gggcggcccg ccgaccctgc cggtggaggt
    15961 gccgtcggtc gtcctggccg cgctggcctc cctcccgctg ggcgcggtac tcggcccgga
    16021 ggcaccgctg atggcactgg gcagcgggct ggcgctgctg acggtgagcg cggcgaaacg
    16081 ggcgaacagc ccgatggtcg gaccgatgct gggcgcggcc ggatcgacgg cggcgatcgc
    16141 cacgatcttc ggcagcccgc tggtcgcggc cgtgatgatg atcgaggcag cgggcctggg
    16201 cggggcgcag ctgaccctgc tgctgctgcc gtgcctgctc tcctccggcg tgggcgcgct
    16261 ggtgttcacc gggttcggac actggaccgg cctgtcgatc ggctcgctga acctgccgtc
    16321 cgtcccgaag gcgcaactgc cggacgccgg ggacttcctg tggggcgtgc cgctggcgat
    16381 ggcgatcgcg gtgatcctgg tcgcggggca gaccctgggc caccgcttcg ccgcgttcac
    16441 ggcccaccgg acggcggtgc ggacggtgct gtccgcggtg ctggtgggtg cctgcatcgc
    16501 cgggtacgcg ctggtgaccg gacgctcccc cgaggaggcg gcactgtccg gccaggccgc
    16561 gctgggacag ctcgcggcgg acccgcggag ctggtcggtg ggcgcgctgc tggccctcgt
    16621 cctgttcaag ggcctgggct ggggtgtggc cctgggatcg ctccgcggcg gcccgatctt
    16681 cccggcggtc ctgctgggcg ccgccctcgg cgtggcggcc ggcggcctgc ccggcctggg
    16741 cgtcgaggcg ggcctggccg ccggcctggc cgcgagcggc gcggcggtca tgcggctgcc
    16801 ggtgaccagc acggtgctgg cggcagcgct gctgggcgac cagtcggcgg attcgatgcc
    16861 gctgctgatc gtctcggcgg tggtgtcgtt cctgaccgcg acgttcgtgc accgggtggc
    16921 cgcgcctcgg ccgacggcgg agggggacgg gggaggggaa gggcggggcc ggggtcgggt
    16981 ggcggcttga gatcggtgtc gtgacaccgg tgcgctggca tcggtgtcac gacaccgatg
    17041 ccgggacatt catgctgcgg catcgatgtc acgacactgg tgtcgcgaca tcggtgtcac
    17101 gacatcgacg cgccatcacc ctcgcgcccc gcccacccac tccgccaccc ccaccccccg
    17161 ctcaccggcc gcaggcgcgg cacggcggcc gggtggcgcg ggcgtagccg agggcggcgg
    17221 cgcccaggcc gaggccccac agccagtagg cgggcatcgc gatccacagg aagggcagcg
    17281 gcagcgtgtc gtcgcgggac gccgggtgga gcgtctcgcc gagcagttgg gcgatgccga
    17341 cgccgaagta caccagcagt ccgaccgaga gcgcggcggc cgggccgagc ggcagccagc
    17401 ggggcaccgg gcggccgccg agcagcggga cggggtgcgg gacgttccgg ccccagcggt
    17461 ggacgaggga gagcggcagg acggtgccgg ccaggacgaa gccggcctcg aacacggcga
    17521 gggagagtcg ctcggccgtc ccgagcggtc ccgggctacc gaagcccagt ccgtactggg
    17581 cgaggatccg cagccagcag gaggcgaccg ccccgtagcc ggccaggcgg gcccagcgcg
    17641 gggtgcgggt gcgggcggcg gggtcgtgcg ggtcgccggt gcggccgcag cggggcagtc
    17701 gccgcgcagg cggcggtggg cgcgggcagc ggcggccagc aggacggcgg tcgcggcgca
    17761 gccggtccgg ctgaggaaac ccgccgccga gccggggagg cccagcccgg gcagcaggcc
    17821 gccgaccacg tccagcagca ggaacgggca gctcagcagc aggacggcgg ccaccgcagc
    17881 ggccccggcg agcagtccgg ggcggtagcg gcgggcccgg tgcaggccgt atccgagcgc
    17941 cgcggcggcg gcggacaggc cgaccgtccc ccagcgggga acgaccagca ggtcggtgcc
    18001 gagccgaccg aaggacgggg cgtggccgag tgcccaccag gtctgcgtca gcccgtacgc
    18061 gagggcggcg gcgagcgcgg cggccgccgt ccggggcggg tggtgggtgc ggtctgccat
    18121 ggcgtccacg ctaggcagcg gcgggtgggc cgggcatcgg ccgcggggag ggccgcgcgg
    18181 gggcggggca ggtcgcggga aggacggggc gcctacccgg cgaggagatt gacgtcctgt
    18241 cggatcgtcc gccaggagga ggcggtggcg gggcaacgcc cccgcatggc aaggctgttg
    18301 gcgcggcgcc gacctgtccg ccggcaacag cggcggcagc agcagcgaca gcgagagcga
    18361 cagcgacggt ggtggccggg ggcgcgcggt ctcccgttgc cggcggcgtt ctcgcgggcc
    18421 gacctcgcgc gcccccggca ctctccgttc aggacggtgg ctccccctcg ggccgccgtc
    18481 ctgcggatcc gccgtccgcg cggctccggc gagcggcggc cgggagcgcg gggcggcggg
    18541 gcgcggccgg tgccggggtt cgggcgggcc gcgggtcgat ggggccaggc cggtggcggc
    18601 ggggcccggg gcggggtcag gaccaggcga tatcccgtcg accggaacgg gccggggcgg
    18661 accgggtgtt cgccatgctg atctccgtac ggtgccggac cggtgcggcc ctggtggatg
    18721 gttcgcggtg ggacgggaca agcctggagc gccccggcaa ccggccgata acatcggcct
    18781 aacgtgcgcc gacgaagcgt cggacggggg gcacgcgaac ggggagcagc acggtgcgct
    18841 tcggtttgct cggcactctg acggcccatg acggagtggc cgaccggccg gtccagggcc
    18901 ccaaagcccg taccctgctg gccgtcctgc tgctgaacgc cgaccggccc gtctcgctcg
    18961 accgcctgct cgacgcgctc tggggcgacc ggccccccgc caccgccgaa gcctcgctgc
    19021 gcaacctggt ctcccggctg cgccggacac tcggcgacga ggacggacag cgactgcggt
    19081 ccaccccgtc cggctaccaa ctctcgctga cagacgacga gttggacact cgacagttcg
    19141 aggccgcgat ccgccgggcc cgctccgcgc acgaggccgg cgacctgtcc gccgtactgg
    19201 ccgagaccgc caccgcactc ggcctctggc gcggcgagcc gctggccgac ctcccggagg
    19261 cggccggggg cggcgcggcg gccgagcagt ggcgggagag ccgcctgcag gccttggagt
    19321 ggcgcttcga cgccgagttg ggcctgggcc gcccgcacgc gccgctgccc gaactcaccc
    19381 gcctggtccg cgagcacccg ctgcgcgagg tcttccacgc ccagctgatg ctggccctgc
    19441 acctgaccgg ctccagggcc cgggccctgg aggtgcacca gcgcctgcgc accgccctga
    19501 tcgaggagtt gggcatcgaa cccggcccca ccgtccgggc cgcgcaccag cggatcctcg
    19561 ccgagccgcc gaccgaaccg agcaacccag ccgaacaggc tgaacagtcg gccgaggcgg
    19621 ccgaggcggc caaggcggca accgaagcgc cgcccgctcc ggccgccacg ctctcggccg
    19681 accgcccaag gccgtcccaa ctcccgctcg tgtcaccgta cttcgttgga cgccaagagc
    19741 aactggcaac cctccgggac gcgttgaccg acacctcgga gcagcccgcg atcgtcgtgg
    19801 tcagcggcct ggccggcgtc ggcaagtccg ccctcgcggt gcgctgcgcc accgacctgc
    19861 ggggcgagtt cccggacggg cagctgttcc tgaacctgcg cggcgccacc cccggcctga
    19921 ccccgctcac cgcccacgcc gcgctcaccg cgctgctgcc cgccctcgac gccgcgcggg
    19981 gcggcgtccc cgaggacacc gacggcgccg ccgccctgct gcgcaccgcc ctggcaggca
    20041 cccgcaccct gctcgtcctg gacgacgcag ccgacctcgc ccaggtccgc ccgctgctgc
    20101 cgaccgcccc cggctgcgcc gtcctggtca ccagccgctc ccccatgcac gccctggacc
    20161 acgcgctgca cctgcggctg gacgtcctct ccgagcacga cggcatcgcc ctggtcgaac
    20221 gcgccgccgg ccgcaccagt gcggaccggt cggtggtcgc catcgagcgg accgacctgg
    20281 cccgcctggt ccggctctgc ggccggcacc cgctcgccct gcggatcgcc ggcgcccggc
    20341 tggccgcccg ccgcaccctc cccgtccggc acctggtcgg ccggctggag gagcacgagg
    20401 accggctgga cgagctcgaa ctcgacgacc tgagcatccg ccgctcgctc gccctgacgt
    20461 acgactcgct gcgcggctcc gcccgccggc cggacgtccg ggccgccgcc gccctcgccg
    20521 cgatcggcac cctcgacctc cccgactact ccgccccgct gctcgccgct gtcctgcgga
    20581 tcacccccgc ccaggccgcc accgccctcg accgcctggt cgaggtcgcc ctgctcgacg
    20641 agccccgccc cgaccggtac gccccgcacg acctggtccg cgactacgcc cgcgaactcg
    20701 tccccgaccc cgccgaccgc accggccacg tccgggccgc gctcgactgg taccgctcgc
    20761 tgaccgtccg gatggccttc gccctcgacc ccggctccgc cctgacccgg gagctgccgc
    20821 cggtcgcccc cgccgaccag ctggaccacg agggcgcgct ggccgccggc gacgccgagt
    20881 tcggcaacct gctgctcctg gtcgaacagc tcaccgccac gaactgggcg acctccgccg
    20941 aggtctcccc gctggcccgg gcgctcttcc cctacctgcg ggtccgcccg cacgcggacg
    21001 cg
//
