LOCUS       NC_016109              24368 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 987213
            Orig. end                         :: 1011581
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azoxy-crosslink"
                     /region_number="6"
                     /rules="(azdH and LPG_synthase_C and azdO and vlmB)"
                     /tool="antismash"
     cand_cluster    1..24368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(azdH and LPG_synthase_C and azdO and
                     vlmB)"
                     /kind="single"
                     /product="azoxy-crosslink"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24368
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:14368]"
                     /cutoff="20000"
                     /detection_rule="(azdH and LPG_synthase_C and azdO and
                     vlmB)"
                     /neighbourhood="10000"
                     /product="azoxy-crosslink"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(azdH and LPG_synthase_C and azdO and
                     vlmB)"
                     /neighbourhood="10000"
                     /product="azoxy-crosslink"
                     /protocluster_number="1"
     misc_feature    complement(2129..2144)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.58"
                     /tool="antismash"
     misc_feature    2130..2144
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     gene            complement(4715..5047)
                     /locus_tag="KSE_RS04330"
                     /old_locus_tag="KSE_08970"
     CDS             complement(4715..5047)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134053.1"
                     /locus_tag="KSE_RS04330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_08970"
                     /product="trypco2 family protein"
                     /protein_id="WP_014134053.1"
                     /transl_table=11
                     /translation="MDIELADAVAAVRDELLKAQSRGAASDLVFEVGPLEMEFEVELRA
                     DAKVGGKFRVWAVSADAEAGVSRGATHRVTFTLTPRLRDGRPALLIHGDPDAPAGPGDL
                     DGYVEN"
     gene            complement(5223..5804)
                     /locus_tag="KSE_RS04335"
                     /old_locus_tag="KSE_08980"
     CDS             complement(5223..5804)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134054.1"
                     /locus_tag="KSE_RS04335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_08980"
                     /product="AAA family ATPase"
                     /protein_id="WP_014134054.1"
                     /transl_table=11
                     /translation="MHRFILTGAPGAGKTTLLRELAARGHRTVPEAATDVIARAQAAGE
                     AEPWTDPDFPLRVLALQRERQRERQWERQNARQGATAAGAVLLHDRSPVCTHALAVYLG
                     RPVPPALAAELERIVDERVYRREVFLVRPIGFCTPSAARRIDYPASLAFERVHQDSYRH
                     YGFRLLDVPPGPVPARADLVADTLARLAPG"
     gene            complement(6020..6571)
                     /locus_tag="KSE_RS04340"
                     /old_locus_tag="KSE_08990"
     CDS             complement(6020..6571)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134055.1"
                     /locus_tag="KSE_RS04340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_08990"
                     /product="EF-hand domain-containing protein"
                     /protein_id="WP_014134055.1"
                     /transl_table=11
                     /translation="MTGLQDRKYGRWFKGADIDGDGFITRRDVLLMSERYITARGLPPD
                     SEGARLLAGQMDGFWTNVIAPMDQDGDGRVDLREMTDGFKRALGDAAQYARQIGPVADC
                     FFDLVDLNGDGKIDLSEFRLMFDAVAAVPGGDSAEVFAALDLDGSGGLDRGEFHQAILE
                     FFYGDDPDAAANHLFGRIDV"
     gene            complement(6641..8938)
                     /locus_tag="KSE_RS04345"
                     /old_locus_tag="KSE_09000"
     CDS             complement(6641..8938)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1134: flavodoxin"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134056.1"
                     /locus_tag="KSE_RS04345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09000"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_033258677.1"
                     /transl_table=11
                     /translation="MPVATHWGSFVAVVDSGRLVRIEPAPDDPAPSPIGPGMVTAADDA
                     ARVLRPAVRKGWLDGLPRTGDRARGADAFVEVGWDEALGLVGGELRRVRERYGDAAVFG
                     GSYGWASAGAFHSAQGQLQRFLALGGGYTDSRNTYSTAALEVVLPHVIGGHPWSYQSRM
                     PMWDEIAEHAELVVAFGGLALKNSQINPGGLARHRTRDLQRRCRDAGVRFVNVSPIRSD
                     TADFLDAEWLPVVPNTDTAAMLGIAHTMLVNGWHDEDFLRRCCTGFDRFADYLLGGADG
                     VPKDAAWAARITGLDRAALTGLARRLTERRSVVMVNYAVQRADHGEQPIWMSVVLAAMA
                     GSMGRPGGGWGAGYATMDATGVAPGRPPVASVPAVPNPVPDFIPVARIADTLLHPGRTI
                     DYDGRRLTLPELRLVYWCGGNPFHHHQDLHRLARAWQAPDTVVVHEAWWNTSAKFADIV
                     LPVATGLEREDFAAGFSDPHLTAMPKVREPAGESRTDHRIFAELAERLGYGTEFTESRT
                     ESEWVRHLYEQTRSALGEAAALPDYDEFRRRGGAPLPPLTGPFPGGFAELRADPAAHPL
                     PTPSGRIEVFSAEIDSFGYDDCAGHPTWYEPAEWLGGERAGRFPLHLVSNQPASRLHSQ
                     YDNGGHSLDSKIRGREPVTINPLDAAARGIADGAVVRVFNDRGGCLAGAILSDEVMPGV
                     VRLSTGAWWDPDQPGLSGTLDRHGNPNVLTADRPCSRLSQGPSALSALVEVEPHGEPLP
                     DVRAFAPPEIER"
     gene            9166..9720
                     /locus_tag="KSE_RS40870"
                     /old_locus_tag="KSE_09010"
     CDS             9166..9720
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS40870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_09010"
                     /product="hypothetical protein"
                     /protein_id="WP_148283057.1"
                     /transl_table=11
                     /translation="MQRPPATGNRPPGLPNGLAWQGRWGPAGRTARPEARIEPEAALSE
                     IGNQQPSAPGADAVLLATGARPATGPFAQRVARLVGLWEADGRSDRWLAGGTAFFLLNC
                     WSMTPGRPATPALRDYLAACRTAAGGGPGWDALLRHRINCPGCGVSWSLENIRACTGCS
                     SYTCDDCQEADHRGEFCEVVG"
     gene            complement(9794..9922)
                     /locus_tag="KSE_RS45610"
                     /old_locus_tag="KSE_09020"
     CDS             complement(9794..9922)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS45610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_09020"
                     /product="hypothetical protein"
                     /protein_id="WP_255518920.1"
                     /transl_table=11
                     /translation="MRARTVDLFIMLCGNPDDSALGAETDRALAELDRLLTAPPGD"
     gene            complement(10001..10996)
                     /locus_tag="KSE_RS04355"
                     /old_locus_tag="KSE_09030"
     CDS             complement(10001..10996)
                     /NRPS_PKS="Domain: LPG_synthase_C (17-311). E-value:
                     1.9e-58. Score: 189.8. Matches aSDomain:
                     nrpspksdomains_KSE_RS04355_LPG_synthase_C.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: LPG_synthase_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134059.1"
                     /locus_tag="KSE_RS04355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09030"
                     /product="bifunctional lysylphosphatidylglycerol
                     flippase/synthetase MprF"
                     /protein_id="WP_014134059.1"
                     /sec_met_domain="LPG_synthase_C (E-value: 2.4e-56,
                     bitscore: 189.8, seeds: 74, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREHPSLDYVLEMISIHAESDNPSSFLAVNEGNSYFALPGRDGVI
                     VYRPAGRYLVQFGGPFAPASSYADLVDGFAEFARRQRRTVVGIQLQHRDALIHARHGYT
                     LNQVGASYAVDLEGFTLAGSRHMQLRNKISRAHRGGLTVLEAPYDEWAGAVADVDRRWL
                     PLKGEGAKPLEYLVGQTGGPMQRHRRLFVAVVGSELVGYVSYSPVYGSRPGWMHDLSRR
                     LPDGQTGVMEAVNKAALETFREEGTRWLHFGFTPFTSLADEREIDNHSPGFSWLMRHLW
                     SRGGVVYPAATQLAYKQKWDQSVITTEYVAFSGKPSIEAFVFVWRAANGV"
     aSDomain        complement(10064..10945)
                     /aSDomain="LPG_synthase_C"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KSE_RS04355_LPG_synthase_C.1"
                     /evalue="1.90E-58"
                     /label="KSE_RS04355_LPG_synthase_C.1"
                     /locus_tag="KSE_RS04355"
                     /protein_end="311"
                     /protein_start="17"
                     /score="189.8"
                     /tool="antismash"
                     /translation="AESDNPSSFLAVNEGNSYFALPGRDGVIVYRPAGRYLVQFGGPFA
                     PASSYADLVDGFAEFARRQRRTVVGIQLQHRDALIHARHGYTLNQVGASYAVDLEGFTL
                     AGSRHMQLRNKISRAHRGGLTVLEAPYDEWAGAVADVDRRWLPLKGEGAKPLEYLVGQT
                     GGPMQRHRRLFVAVVGSELVGYVSYSPVYGSRPGWMHDLSRRLPDGQTGVMEAVNKAAL
                     ETFREEGTRWLHFGFTPFTSLADEREIDNHSPGFSWLMRHLWSRGGVVYPAATQLAYKQ
                     KWDQSVITTEYVA"
     misc_feature    10949..10964
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.58"
                     /tool="antismash"
     misc_feature    10954..10968
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.01"
                     /tool="antismash"
     misc_feature    complement(11024..11035)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    11070..11084
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(11098..11108)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            11154..12290
                     /locus_tag="KSE_RS04360"
                     /old_locus_tag="KSE_09040"
     CDS             11154..12290
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: azdH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134060.1"
                     /locus_tag="KSE_RS04360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09040"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_014134060.1"
                     /sec_met_domain="azdH (E-value: 4.2e-178, bitscore: 590.6,
                     seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSLDIARDSCERLHPGMIKSFLEVPLMEREAKGSSVVEVFRRHG
                     GPGLLVPAAYGGLGASALDAVRVTRAIGAHSPSLAAASAMHNFTAALLFALAERVVPPG
                     PEQARILARIAPEGMLLASGWAEGRTQQDILDPVMTAEPTERGFLVNGSKKPCSLARSM
                     DLLTASTILPDDDGGTSLVLLLIPADSPGISVHPFWDSPVLAAAQSDEVRLENVHVPER
                     LVVRGTADDPDRLDDIQSGTFVWFELLVTCAYVGAASALTEMVLQRGRGSTTDRAALAV
                     LTESAVLLTEGTARAVDAGLAGEDAVAAALTTRFAVQRALAGIADQAAELLGGIAFIRE
                     PEIAYLCSALQPLAFHPPGRTSSSRHLIDYYNGGALRI"
     gene            12329..12817
                     /locus_tag="KSE_RS40875"
                     /old_locus_tag="KSE_09050"
     CDS             12329..12817
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: azdO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134061.1"
                     /locus_tag="KSE_RS40875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09050"
                     /product="hypothetical protein"
                     /protein_id="WP_014134061.1"
                     /sec_met_domain="azdO (E-value: 4.7e-69, bitscore: 230.1,
                     seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQANAFESPTTMRLHRAEYLAAFAVSVGLFVAHADRVRWLPAVL
                     LFVYIDVIGYLPGAVAYRRTPGGRISKNYYRAYNLMHSALTQGLVAGVWIWAWGAEWAL
                     LAIPIHLCADRGIFGNFLKPLALPFEPVPDQRFAELTARLFPRGTRGGNPARTPESAT"
     gene            12814..13377
                     /locus_tag="KSE_RS04370"
                     /old_locus_tag="KSE_09060"
     CDS             12814..13377
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016646 - oxidoreductase activity, acting
                     on the CH-NH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.5"
                     /locus_tag="KSE_RS04370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09060"
                     /product="flavin reductase family protein"
                     /protein_id="WP_014134062.1"
                     /transl_table=11
                     /translation="MTRPSGQAPAATPHAVSRRLTTGVSVLTSAHGGSVHAATASTVAV
                     LSQQPLTLAVSLRRNSVLAELATLSGYFVVNVLTSRQAVLADWFAFPRRPRGRAQFGPV
                     DWRTDTATGIPVLTDHLALLTCRIVGRTAVGADDDLIIAEVTAAEAGRGNPLVNYDGRL
                     LDPEFNAVVRRPGWRPRAHEPVLD"
     gene            13388..14368
                     /locus_tag="KSE_RS04375"
                     /old_locus_tag="KSE_09070"
     CDS             13388..14368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azoxy-crosslink: vlmB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134063.1"
                     /locus_tag="KSE_RS04375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09070"
                     /product="VlmB-like protein"
                     /protein_id="WP_014134063.1"
                     /sec_met_domain="vlmB (E-value: 1.5e-172, bitscore: 571.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPIPAETGWDSAPGLLEGAMTLDLTPEQCDLGYWLRGVAQGTL
                     AGRAETGHTDAEPTPEHMRADGPLRDAQVLELSCRSVAEAQATRVLAHYVAQAPDIVEL
                     EFFTTQLVDEARHSMVFRRHLLAMGVPADRLHASIAEVSAEYRREVLEPILDFALTTVR
                     DEGDFVGGVAVFTIIIEGVLAPAAELSERKWNLLDPAAGAIARGAAIDEVRHLTVGSSV
                     VRRHLLRRPERKAALLDIVRRGREIWDGIPDRKHVLRREELFQAGMREHADLLAGYEVW
                     PGQPLLSTTPEQRYAMAEQWTDRMAAARLVHMGLPEAIDLLRLTD"
     gene            14415..16043
                     /locus_tag="KSE_RS04380"
                     /old_locus_tag="KSE_09080"
     CDS             14415..16043
                     /GO_function="GO:0016830 - carbon-carbon lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019752 - carboxylic acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134064.1"
                     /locus_tag="KSE_RS04380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09080"
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="WP_014134064.1"
                     /transl_table=11
                     /translation="MAALPTGIPFGPDDAAWSTGLDRLRTAGATRVSAPSADPRETYPQ
                     LPELPPGRFQLPARGLDATEYAQAEDLFRRYVEDHSSRSLGYQLHWSEDFARRLAPYLG
                     LQLNNIGDPYQHGAFMPNSKVLERAVLDYFASLWNAKWPHRAGDPESYWGYVLTMGASE
                     GNIQALWNARECLSGKPLAGQPRLPADTAHENPNARHPVVFFSRETHYSLTKAVNLLGL
                     DTFHALGSSRYPDANPLGPGTEWPTEVPCVGGVDGPGAIDVEKLSLLVRFFVRRGHPVF
                     VNLNYGSTFKGAFDDVPEAARAVHEICAEYGMAERTFPSDREGTGARPRPGYWIHVDAA
                     LGAAYVPYLRMARAAGLVESAPPPFDFRLPQVHSLTVSAHKWMGAPWPCGVFMTRNGLR
                     MPPPRSSEYIGGTDTTLSGSRNGFSALLMWDYLAHHSYDDLARQAAECDRLARLAHERL
                     LKLQSGLGVDLLVSRSPWSLAVRFRRPDEAILRRYSLAYETLLVDGVERPYAHLYVVPH
                     VTEGLIDALLRDLGQPGAFAGGAAA"
     gene            16040..16999
                     /locus_tag="KSE_RS04385"
                     /old_locus_tag="KSE_09090"
     CDS             16040..16999
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134065.1"
                     /locus_tag="KSE_RS04385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09090"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_014134065.1"
                     /transl_table=11
                     /translation="MSAPRRPLRFGVLLPTREQAVTGRYDAGALLAFARRAEELGFDSL
                     WAGDSLTARPRFDPLVTLSAAGAVTRRVTLGTAAMIPVLRHPLIGANMVAALDHVCGGR
                     LTLGLGAGFPLPETEAEFSAAGVEYAARGRLLRETVSRWREAWAASGAEAGPHLLPPPL
                     RAGGPPLWLAGSDTPRVLRRVAATYDGWLPFLPSADAYRRAWRRVGEHLDLAGRPRGEV
                     VPALYATVTLAADRARAAREMDGYLGRYYRRSLAEMSAFQLCVPGGVEECAKELAEFAL
                     AGTEHFVLRVGSMDFAPHLERIATELLPAVRALVDPTG"
     gene            17035..17460
                     /locus_tag="KSE_RS04390"
                     /old_locus_tag="KSE_09100"
     CDS             17035..17460
                     /GO_function="GO:0051920 - peroxiredoxin activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014664.5"
                     /locus_tag="KSE_RS04390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09100"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_014134066.1"
                     /transl_table=11
                     /translation="MTTYRNAEERHTSGLAKLEEVAGTELKERFLENLRNVSPEFRDYV
                     SDFIYGEIYSREGELDLLEKEQVTLVTLAAQGGLDYELRLHLRAALQLGISPARIADLF
                     IQMSPYAGFPRGLSAILCLKDALSDVTTAEFVREHRR"
     gene            17489..18706
                     /locus_tag="KSE_RS04395"
                     /old_locus_tag="KSE_09110"
     CDS             17489..18706
                     /EC_number="2.6.1.-"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-395). E-value:
                     6.1e-53. Score: 172.1. Matches aSDomain:
                     nrpspksdomains_KSE_RS04395_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003969844.1"
                     /locus_tag="KSE_RS04395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09110"
                     /product="pyridoxal phosphate-dependent aminotransferase"
                     /protein_id="WP_014134067.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.7e-51, bitscore:
                     172.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 1.1e-06, bitscore:
                     26.7, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.7e-09,
                     bitscore: 36.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFIRSSRFAEVRYEIRGPLSEEARVLEEAGRTVLRLNTGDPAAF
                     GFRPPPAFLAEVLLRARHSNGYSDARGLLESRQAVAEWYRAQGVADVGAGDVVLGNGTS
                     ELIAMALQALLEPGDEVLVPSPDYPAWTANTSFASGRPVHYRCDESAGWLPDLDDLAAR
                     VTSRTRAVVLINPNNPTGAVYPGETVEGVLEIARRHGLMVLSDEVYDRILYDGAVHQRP
                     AALGPDVVCLTFGSLSKSYRVAGFRAGWVVLSGHRSSARDYFEGLLALASLRVCANTLG
                     QCAVEVALADPESRGTLNLALPGARLHQQREQAWKRLTAIPGVSCVKPMGAVYAFARLD
                     PEVYKIHDDGRLALDLLRSKRVQIVQGTGFNWPAPDHFRMLTLPRVEVIDTAVNRIERF
                     LADYVQ"
     aSDomain        17585..18673
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KSE_RS04395_Aminotran_1_2.1"
                     /evalue="6.10E-53"
                     /label="KSE_RS04395_Aminotran_1_2.1"
                     /locus_tag="KSE_RS04395"
                     /protein_end="395"
                     /protein_start="32"
                     /score="172.1"
                     /tool="antismash"
                     /translation="TVLRLNTGDPAAFGFRPPPAFLAEVLLRARHSNGYSDARGLLESR
                     QAVAEWYRAQGVADVGAGDVVLGNGTSELIAMALQALLEPGDEVLVPSPDYPAWTANTS
                     FASGRPVHYRCDESAGWLPDLDDLAARVTSRTRAVVLINPNNPTGAVYPGETVEGVLEI
                     ARRHGLMVLSDEVYDRILYDGAVHQRPAALGPDVVCLTFGSLSKSYRVAGFRAGWVVLS
                     GHRSSARDYFEGLLALASLRVCANTLGQCAVEVALADPESRGTLNLALPGARLHQQREQ
                     AWKRLTAIPGVSCVKPMGAVYAFARLDPEVYKIHDDGRLALDLLRSKRVQIVQGTGFNW
                     PAPDHFRMLTLPRVEVIDTAVNR"
     gene            18741..19742
                     /locus_tag="KSE_RS04400"
                     /old_locus_tag="KSE_09120"
     CDS             18741..19742
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134068.1"
                     /locus_tag="KSE_RS04400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09120"
                     /product="serine/threonine dehydratase"
                     /protein_id="WP_014134068.1"
                     /sec_met_domain="PALP (E-value: 9e-60, bitscore: 201.3,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDPAFPAYDDVEAAARRIAGVVRRVPVVAGDADAFGGSEVYLVP
                     EFIQNSGSFKDRGAANFIAAHLESGTVPEAGVVIASGGNAGLACAWAARLHAVRATVFV
                     PETAPRVKVAKLLAYGAEVRRVGTEYAHAAAAAAAFADATGALPSHAYDDPHIAAGAGT
                     LLLEILDQVPGLDSVVVAAGGGGLFTGTAITATTHGVRVVAVEPRTCRCLNAAIEADAV
                     VDVAVDSVAADALGARRASEMALHWARASGADSLLVPDETIVAARRTLWQRYHFGVEHG
                     GATAFAALLSGRYAPEPGERVAVVLCGANTDPTDLATDPPDPAGPAPAPAPA"
     gene            19872..21341
                     /locus_tag="KSE_RS04405"
                     /old_locus_tag="KSE_09130"
     CDS             19872..21341
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1038: phenylalanine-specific permease"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134069.1"
                     /locus_tag="KSE_RS04405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09130"
                     /product="APC family permease"
                     /protein_id="WP_014134069.1"
                     /transl_table=11
                     /translation="MTASEPPARDGRLVRTLTTPKIVFIIIAAAAPLAAMVFTVPLAFS
                     IGTGPSVPALFVFAGLTLLCFTSGYAAISRRISHAGGFYTYIAAGLGRPVAVAGGLIAV
                     IAYNTVTIGLLGAFAYFAHSVTASYGLDVPWEAWAGAGLLSIGVLGYRHVEFSARVLSV
                     LMVCEMAVLLALDVAVLAHRGLAALPAQSFSPGLIAAPGLGVSVMFAFASFIGFESASL
                     YGEEARDPGRSVPRATVIAVLLVAGFYALTSWVAVGAVGPANVRATASGHLDDLFFDLG
                     DSYLGGVTSTVMQVLLCTSLFAGWLALHNAANRYMFVLGRDRVLPRWLDAVHPRHGALH
                     HACVAQSVTSAVVAAFFAAAGIDPYLGMSTSMLGLGTLGVIALQALASLSVLGYYRGRR
                     RGHWWRTRMAPALGAVGLVAAAVLVVRNFPVLTGTTNPVVTALPWLLPLAGAIGVGHAH
                     RMRARHGERYAALAGVEHAGRGGAARPDGRD"
     gene            complement(21404..22666)
                     /gene="serS"
                     /locus_tag="KSE_RS04410"
                     /old_locus_tag="KSE_09140"
     CDS             complement(21404..22666)
                     /EC_number="6.1.1.11"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004828 - serine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006434 - seryl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="serS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014134070.1"
                     /locus_tag="KSE_RS04410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_09140"
                     /product="serine--tRNA ligase"
                     /protein_id="WP_014134070.1"
                     /transl_table=11
                     /translation="MHPLRDLLSPEAVTALARRGYRLDADSLAELAALRSRLVAERDAL
                     HAAIRITTRRHRPATQEDAAEGRDLRQRAGDLAAQLREAEQRLRDFLLAVPNTPLECVP
                     PGRADEAAVELRQWGARPEFGFAPRDHVALGAGSGILDLERAGRVSGARFAVLRGAGAR
                     LERALASFLLDLHTREHGYVEMSVPHLVTRESMTATGQLPKFADDLFGTRAAERELFLI
                     PTAEVPLVNLFRGETLSSAALPLAVTAHTACFRSEAGSYGRDTRGVIRLHEFAKVELVR
                     LCAAQDARHEHEVLLGHAEEALRRLGLHYRVVELRTGDLGFSARRTYDLEVWLPGQQRY
                     REISSVSDCGTFQGRRAGIKVKTAGANEFAATLNGSGLPIGRTMAALLEQFQREDGSVA
                     VPAALVPHTGFEVIAPDGGVR"
     misc_feature    complement(23634..23652)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.76"
                     /tool="antismash"
     misc_feature    complement(24013..24027)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 cagcgcgtcc cgcagtcgca ggcaccgggc caggccgggc tggaccagtg cgggctggtc
       61 ctcggcgacg ctccgcagcc ggtcgatggc ctcgcgcagg ccggcgcgcg ccgtgtcgag
      121 gtcggtgccg gtcagcaggc gcacctcgcc gtagaggtag agggcgtcca cgatcaggag
      181 tccggtcggg gcctcgctgt cgcgtagcag ggtgacggcc cgcgtggtgg tctccgccgc
      241 ctgctcgccc tggccgtcgt gggccaggca gaggcccagt acggccatgg ccgcggccag
      301 cgcggcctgg ccgcggcccg ggttggcctg gccgcggccc gggttggcct ggtgcatccg
      361 gtgctggagg tcgacggcct cggtggcgtc gtccagcgct ccggggagcg gcggccgccg
      421 gcgtgcccgg acgcgggccc gggtcgtcag ggcgttggcc acgatgcctt cgaaggcttc
      481 cgcgccgctg ccgttgatct gccgggccgc ccggaccgcg cggtccagaa cttcggcggc
      541 ggacggttcg tccaggtcgt cgagcagcgc gccgtgcgtg gtgagcgtca tcgcgatccc
      601 ggcgtggcgg ttggggtcgc cgtccggtgt ccgttcgaag gcggcgcgga tctcctccag
      661 cacgtccagt gcctcggtct gtcggccggc tgcccagagc accgggacct gggtcgtcag
      721 ggccagggcc ggtgcgggca tctgcgcgtt ccactcgctg cgggacagcg ctcgccacag
      781 ttcgacggac tcggtgatgt gggccgcggc ctcgctcgcg cggtccagtc ggctcagcac
      841 gccggcgagg tcggcgaggg cccgggcgag ggcgacgcgc cgttcggggg tcggctcggc
      901 ctcccagcgt tcgcgatgga tcgccagcac ctcggccgcg atctcggcgc cttccagcag
      961 ccgtccgctg ccgacgagtt ggtactggaa gtgggtgagg ttggcgagca gctccggctg
     1021 gtggtggtcg gggtcgacca gcgccagttc acgctgtgcc gcgatcacca cgcgcagcgc
     1081 cgccagtgcc tcctccggcc ggccggccag gcccagcagc gcgctgagcg tggcgaggat
     1141 gcccgcggac tcggggtggg ccgccgtggg tgtcgcggcc gtgaccgcct cggcggccag
     1201 gtcggccgcc tcttcccgcc gtccggtctt gtccaggcag atcgcgtggg tggtgagcaa
     1261 ccgggccagc agcgggttgt gggcgtcggg gtcctcggcg gccagttccc gggcgatccg
     1321 tacgccctcc gcgcaggcgg ggagtccctc ggcggggcgg ccggccagcc ggtgggcgtc
     1381 ggcgatgttg ttcaggctgc gtgcgaggtt cggccgggcg gggccggcca ggtggccggg
     1441 gagggcgcgg tagatgccga ccgcctgctc cagcttggcg agtgactccg ccggccggtc
     1501 ggcggcaccc aggcacagtg ccagggtgca gagcgccatc gcgtggtcgg tggcgtgggc
     1561 gtcgggcagt tcgcggtgca gctcggcgta gagggcgacg gcgcgttcgg ccgcgcgcac
     1621 cgcctccgcc gcccggccga ccgtgtacag ctcgttggcg tacgagttga gcgtcatcgc
     1681 gaacatgtcg cggtggggca atggttgacg ctccgtcact tcttcgtaga tctgcacggc
     1741 ttcgctcacc gcggccagcg cctcggtgct ccggccgacc cgtcgcaggg cgatggagta
     1801 cgagttgagc acctgggcca gtccgtcccg gtaggcggcc ggccggccct cggcgaggcg
     1861 gcggcggacg gccacggact cctcgacggc ccgcatcgcc tcctggtcgc ggccggcgtc
     1921 ggcgaggcag ttggagagcg tgcccagcgc gatggccagc aacggctggt gggcgtccgg
     1981 ccgttggcgg gccagcgggc gcagcagggt ggtcgcctgt cggctccggt ccagggcttc
     2041 ggcgttgcgt cccgcctcgt tgtggtgcaa cgccaggttg tgcagtgcgc ggaccagcga
     2101 gatcgcgagc gcctcaccgc cggtggcggc gaccaggcgt tccagtcgtg ccaccgcctc
     2161 ctcccggagc ggcagcgcga gttgcggctg gccgaggtcg ccgtgcacgc tggcgagggt
     2221 gccgaccgtg atgggcaggt actccggctt ctccagggcg ccgcgctccg cgagttcccg
     2281 gttgagggcg acggcctgcg cggccggggc gagtgcttcg gccggccggc ccaggctgag
     2341 caggaagagc gcctggttgt tgaggcaccc gctcagcttg ttccggtggg ccgtcccgag
     2401 ttcggtcgcg aacccgtgct cggccagcgc gggttggagc agcgcgatgg cttcctcgac
     2461 caccgccagg gcgcggcccc actccccggt gtcggcgtac cccttgccca gcgcccgcag
     2521 gtcggtgacc agcgccagca ggtcgggccc gttgccgacc aaggcggccc ggcggtgcgc
     2581 gaccaggcgc tccatcagcc gtacggccca gggcccgagg tggtaggagt ggtcgggcag
     2641 gacgtccagc cacgcctcca gtcgcccgat gtccgtcccc ggggcgtcga gcagtgcctc
     2701 cagcgcggcg agcagcggtt cgggccgctc gacctggggc accacggcga gggcgggcag
     2761 ggccagttcg tcgggccggt cggcgcagag ccgggtgagt accgggccca gctcggcccg
     2821 cagcggctgg tggccggccg cgcggctgag cacggtgagc atccgctcgg ctgacgggcc
     2881 gtcggctccg gcggccagcg cgggcagcag gtggcgacgg gtgagcacgc ggccgcccgc
     2941 gaagcgttcg gccagccggt cgggttgcag tccgccccag tgcgcgagac cggtgcggtc
     3001 gggtgggtag gcggcggcga gccagtcgcc gaacttccag cggttccctt cgtcggccag
     3061 tccgcgcacc cggcgcaggg ctccgtcgac ccgctcgggg gtgtccgcgc cgagcagcac
     3121 cacggccgcc agggcgtccc ggaacagctc ggcgtcgggc gcctggtcgg tcgggatgcc
     3181 gcgggccgcc agcaggccgt tccagtagcg tgcttcgtgg cccagcaggc gttgctcgac
     3241 gtcgtcgggg cgcccggggt cgccgatcag gccggaccgg ccggcgggct tcggcgggtc
     3301 ggtcggcccg ccggcgtcca acaggtcggc cagcgcggtc atgtgcaggg tcagcaggtt
     3361 ggcgaagccg gggtcggcga ggtcgcgctc gggtagggcg gccgccagtg cggtccacgg
     3421 ggtgcggcct tccgcggccg ggagccgggc cgcgaaggcg agcgccgccg cgcggtacag
     3481 cgccgggcgt ccgtcggggt cctcgcccag cggcggcagc gggatcgccg cggcgcgccc
     3541 gagcacggcg gcggtggccg ggctgagttc gcgcgcgtgg tcccaccagt cgccgtcggt
     3601 gcgcgcgatc agcaccacct tgaacgacag ttcgcgcggc cgggtgaccg ccagcaaccg
     3661 gccgacctgc tggagccggt tctccgcgta gtcgagcacc accagcatcc ggcgggtggt
     3721 ccgctggagc ggggtgagcc gctcggcggt cagctcctcg tcggagcgca gccagaccgc
     3781 ggtccagcgg ccgtggtcgg cgccgtcgga cggggtgacc agctgccggg ccagctcccg
     3841 caccagccgc gtcttgccct ggccgccggg gccgtgcagc agcagggctt cgaccccgtc
     3901 ctgccggcac cagttgacca ggtcggacag caggtcccgc cggccgtgga acccgaccgt
     3961 ctcccgttcg ggccgcagca gcgcgctggg tgagcggtcg gcgcccgcca ggccgagcga
     4021 ctcggggccg gccagcgggg cgaactcgac ggcctccaag tggagcgcgt ccgcgccgtg
     4081 ctccgccagc gccgcgcgga aggaggcgtc gcggagcagc aggtaggcgg gcacggcttc
     4141 gagccggccg tgctcggagt gggccacctc ggcggccacc accccgacca cgaagccgtc
     4201 gcagaggagg gcggccccgg agagtccgcc ccagggcacg acctcccccg tccagtgcgg
     4261 cagcggggtg ccgaggtcga cgacgtagcg gttggacagc gccagactgg cggggttgac
     4321 ggtgccgctc tcctgccaca cgtcggtgta ggccttgcgg gcgggcccgt cggccgtggc
     4381 gcggtactgg gcgagttcgg gcgagccctg gacctggcac gcacggtccg tcaggtcggt
     4441 gacgaactcc ccccagcgcg cgcccggcgt acccgccgcc cgccagcgcg ggtccgccac
     4501 ccgcagcagc gcggcgtcat cgcgtccgcc gccggtgccc cgccagacca cagcggcggt
     4561 cgtcggctgc cggtcgccgg gccggtggac cggcacggct tcggcgcctt cgaccacatg
     4621 ggccgaggtc agcaccagcg cggggccgat caggtagccg gatcccttgc cgtgcggtcc
     4681 gtcgaccagg accacccgcg tctcggccac cggttcagtt ctccacgtag ccgtcgaggt
     4741 cgccggggcc cgccggggcg tcggggtcgc cgtggatcaa cagggccggg cggccgtcgc
     4801 gcagtctcgg cgtcagggtg aaggtgaccc ggtgcgtggc gccgcgcgag acgccggcct
     4861 cggcgtcggc ggagaccgcc cagacccgga acttgccgcc gaccttggcg tcggcacgca
     4921 gttcgacctc gaactccatc tccagcgggc cgacttcgaa gaccaggtcg gaagcggccc
     4981 ccctgctctg ggccttcagc agttcgtccc gcacggctgc caccgcgtca gcgagttcga
     5041 tgtccatgtc gccgtcccct cccctggctc ctggcgtcgc cggacacgat aacggctgac
     5101 ggatcacggc gcgggcgatc accgcggaac gttcccgagc cgctcgtcgc caccgccaag
     5161 gggtcggccg agcgacttcg gcgaggttct ccccggcgga acgaccccgg cccggcgggg
     5221 tgtcagccgg gggccagtcg ggccagggtg tcggcgacca ggtcggcccg ggcggggacg
     5281 ggtccgggcg ggacgtcgag cagccggaag ccgtagtggc ggtaggagtc ctggtggacg
     5341 cgctcgaacg cgagcgaggc cgggtagtcg atccggcggg cggcgctcgg ggtgcagaag
     5401 ccgatcgggc ggaccaggaa cacctcgcgc cggtacaccc gctcgtcgac gatccgttcc
     5461 agttcggcgg ccagcgcggg cgggacggga cgccccaggt acaccgccag cgcgtgcgtg
     5521 cacaccggcg agcggtcgtg cagcaggacg gccccggcgg ccgtcgcgcc ctgtcgtgcg
     5581 ttctgccgtt cccactgccg ttcccgctgc cgttcccgct gcagggcgag cacccgcagc
     5641 gggaagtccg ggtcggtcca cggttcggcc tcgccggccg cctgggcccg ggcgatcacg
     5701 tcggtggcgg cctccgggac ggtccggtgg ccgcgggcgg ccaactcccg tagcagggtg
     5761 gtctttccgg cgcccggggc gccggtgagg atgaagcggt gcatggcggt cgactccggt
     5821 tcggcgcgcg ggacgggcgg tcgcggtgcg gtacggaggc ggggagcggg gcgccgacac
     5881 ggcgcggaag gcggcggggc ccggcgggga gggctgcacc cgcggacgcc tggcgtacgg
     5941 cgtacgccac cgggggtccg cccggcggcc cgaaccgggg gcccgccccg gttcgcgtcg
     6001 ccgggccggc gcgccgccgt cagacgtcga tccggccgaa caggtggttg gcggcggcgt
     6061 ccgggtcgtc gccgtagaag aactccagga tcgcctggtg gaactcgccc cggtccagtc
     6121 cgccggagcc gtccaggtcc agcgcggcga agacctcggc gctgtccccg ccggggaccg
     6181 cggcgaccgc gtcgaacatc agccggaact cggacaggtc gatcttcccg tcgccgttga
     6241 ggtcgaccag gtcgaagaag cagtcggcga ccggcccgat ctgccgcgcg tactgggcgg
     6301 cgtcgccgag cgcgcgcttg aagccgtcgg tcatctcgcg gaggtcgacc cgcccgtcgc
     6361 cgtcctggtc catcggggcg atgacgttcg tccagaagcc gtccatctgc ccggcgagca
     6421 gccgggcgcc ctcggagtcg ggcggcaggc cgcgggcggt gatgtagcgc tcgctcatca
     6481 gcaggacgtc ccgccgggtg atgaatccgt cgccgtcgat gtcggcaccc ttgaaccacc
     6541 ggccgtactt gcggtcttgc agtccagtca tggtgacgca cggtatcgag ccgcccggcc
     6601 gcgggcaatc gaacgggcgg gcggcggccg gacgccccga tcagcgttcg atttccggcg
     6661 gggcaaaggc ccgcacatcg ggcaggggtt cgccatgggg ttcgacctcg accagcgcgc
     6721 tgagcgcgct cggcccctgc gagaggcgcg agcacggccg gtcggcggtg aggacgttcg
     6781 ggttgccgtg acggtcgagc gtgccgctca ggcctggctg gtccgggtcc caccaggcgc
     6841 cggtggagag ccggacgacg cccggcatca cctcgtccga gaggatcgcg cccgccaggc
     6901 agccgccccg gtcgttgaag acccggacga ccgcgccgtc cgcgatgccg cgcgcggccg
     6961 cgtccagcgg gttgatcgtc accggttcgc ggccgcggat cttcgagtcg aggctgtggc
     7021 cgccgttgtc gtactggctg tgcaggcggg aggccggctg gttggagacc aggtgcagcg
     7081 ggaagcggcc ggcccgctcg ccgccgagcc actcggccgg ctcgtaccag gtcgggtgcc
     7141 cggcgcagtc gtcgtagccg aaggagtcga tctcggccga gaagacctcg atccggccgg
     7201 acggcgtcgg cagcgggtgg gccgccgggt cggcccggag ctcggcgaag ccgccgggga
     7261 acggcccggt cagcggcggg agcggggcgc cgccgcgccg ccggaactcg tcgtagtccg
     7321 gcagcgcggc ggcctcgccg agcgcgctcc tggtctgctc gtagaggtgc ctgacccact
     7381 cggactcggt ccgcgactcg gtgaactccg ttccgtagcc gagccgttcg gccagttcgg
     7441 cgaagatccg gtggtcggtg cgcgactcgc cggccggttc gcggaccttc ggcatcgcgg
     7501 tgaggtgcgg gtcggagaag ccggccgcga agtcctcgcg ctccaggccg gtggcgaccg
     7561 ggaggacgat gtccgcgaac ttggccgagg tgttccacca cgcctcgtgc accaccaccg
     7621 tgtcgggcgc ctgccaggcc cgggccagcc ggtgcaggtc ctggtggtgg tggaacgggt
     7681 tgccgccgca ccagtagacc aggcgcagct cgggcagggt gaggcggcgg ccgtcgtagt
     7741 cgatggtccg gcccgggtgc agcagggtgt cggcgatccg ggcgaccggg atgaagtccg
     7801 gcaccgggtt ggggacggcg ggcaccgagg ccaccggggg gcggccgggg gcgacgccgg
     7861 tcgcgtccat cgtcgcgtag cccgcgcccc agccgccgcc ggggcgtccc atcgagcccg
     7921 ccatcgctgc cagcaccacg gacatccaga tcggctgttc gccgtggtcg gcccgctgga
     7981 ccgcgtagtt gaccatgacc accgagcgcc gctcggtgag gcggcgggcc aggccggtga
     8041 gcgccgcccg gtcgaggccg gtgatccggg cggcccaggc ggcgtccttg gggacgccgt
     8101 cggccccgcc gagcaggtag tcggcgaagc ggtcgaagcc ggtgcagcag cggcgcagga
     8161 agtcctcgtc gtgccagccg ttgaccagca tggtgtgcgc gatgccgagc atcgcggcgg
     8221 tgtcggtgtt cgggacgacg ggcagccact cggcgtcgag gaagtcggcg gtgtcgctgc
     8281 ggatcgggct gacgttgacg aaccgcaccc cggcgtcgcg gcagcggcgc tgcaggtcgc
     8341 gggtccggtg ccgggccagg ccgcccgggt tgatctggct gttcttcagg gccaggccgc
     8401 cgaacgccac cacgagttcg gcgtgctcgg cgatctcgtc ccacatcggc atccgggact
     8461 ggtagctcca cgggtgcccg ccgatcacgt gcggcaggac cacctccagc gccgcggtgc
     8521 tgtacgtgtt gcgcgagtcg gtgtagccgc cgccgagcgc caggaagcgc tgcaactgcc
     8581 cctgcgcgct gtggaaggcg cccgcgctcg cccagccgta ggagccgccg aacaccgcgg
     8641 cgtccccgta ccgctcccgg acccggcgca gttcgccgcc gaccagcccg agcgcctcgt
     8701 cccacccgac ctcgacgaag gcgtccgcgc cgcgcgcccg gtcgccggtc cgcggcaggc
     8761 cgtccagcca gcccttgcgc acggcggggc gcagcacccg ggcggcgtcg tcggcggccg
     8821 tcaccatgcc ggggccgatc ggcgagggcg ccgggtcgtc cggcgccggc tcgatcctga
     8881 ccagccggcc ggagtcgacc accgcgacga aactgcccca gtgcgtggcc accggcatcc
     8941 gtcgttccac cgtgcaccaa ctccgtcccc gccgcgtccg tcgtcgcccg ccgggccgct
     9001 cggcacgggg gcggctgccg gggacgagcc tgcccgcgcc gccgggcccg catgcggggc
     9061 gccgggggcg ccgtcccgct tcggggtggc tttcggcgac ttcccggacc gggcggcggc
     9121 gcggtcgcta cgatgcgacg ggcgtgcggt cgcccgccga ggcgggtgca gcggcccccg
     9181 gcgaccggaa accgcccgcc gggcctgccc aacggcctag catggcaggg tcgttgggga
     9241 ccggccggac ggacggcccg ccccgaagca cgcatcgagc cggaggccgc cctgtcggag
     9301 atcgggaacc agcagccgtc ggcgcccggc gccgacgcgg tgctgctcgc cacgggcgcg
     9361 cgccccgcca ccggaccgtt cgcccagcgg gtcgcccgcc tggtcggact ctgggaggcc
     9421 gacgggaggt ccgaccgctg gctggccggc ggcacggcgt tcttcctgct gaactgctgg
     9481 tcgatgaccc cgggtcggcc ggccaccccc gccctccggg actacctcgc agcgtgccga
     9541 accgccgccg gcggcggccc cggctgggac gccctgctcc gccatcgcat caactgcccg
     9601 ggctgcggcg tcagttggag cctggagaac atccgggcgt gcaccggctg ctcgtcctac
     9661 acctgcgacg actgccagga ggcggaccac cggggggagt tctgcgaggt cgtgggctga
     9721 ccgccgcggg ccggtcggac gggctccgcc cggcccgcgg cggtcagccg accggttccc
     9781 ggcccgaaag ggctcagtcg ccggggggag ccgtcagcag ccggtcgagt tcggcgaggg
     9841 cccggtcggt ctcggcgccg agggcgctgt cgtccgggtt gccgcagagc atgatgaaca
     9901 ggtcgaccgt acgggctcgc acggcttcca gttccgagct ttcaggtgcg ggtttcacgg
     9961 ccgtttcctt cctctctcgc agttttcggt ccgcatcgga tcacaccccg ttggcggccc
    10021 gccagacgaa cacgaacgcc tctatgctcg gcttcccgga gaaggccacg tattccgtgg
    10081 tgatgacgct ctggtcccat ttctgtttgt aggccagctg cgtcgccgcc gggtacacca
    10141 cgcctccccg gctccacagg tgccgcatga gccaggagaa tccggggctg tggttgtcga
    10201 tctcccgctc gtcggcgagg gaggtgaacg gggtgaatcc gaagtgcagc cagcgcgtgc
    10261 cctcctcccg gaaggtctcc agcgcggcct tgttgaccgc ctccatgact ccggtctggc
    10321 cgtccggcag ccgccggctg aggtcgtgca tccagccggg gcgggagccg tagaccgggg
    10381 agtacgagac gtagcccacc agttcggagc cgacgacggc gacgaagagt cggcggtggc
    10441 gctgcatcgg tccgccggtc tggccgacca ggtactccag cggcttggcg ccctcgccct
    10501 tgagcggcag ccagcggcgg tccacgtcgg cgacggcccc ggcccattcg tcgtagggcg
    10561 cctccaggac ggtcaggccg ccgcggtggg cgcgggagat cttgttgcgc agttgcatgt
    10621 gccgggatcc ggcgagggtg aaaccctcca ggtccaccgc gtaggaggcg ccgacctggt
    10681 tgagggtgta gccgtgccgg gcgtggatca gggcgtcgcg gtgctgtagt tggatgccga
    10741 ccaccgtgcg ccgctgccgc cgggcgaact cggcgaaacc gtcgaccaga tcggcgtacg
    10801 aggaggccgg ggcgaagggc cccccgaact gcaccaggta gcggccggcc ggccggtaga
    10861 cgatcacgcc gtcccgcccg gggagggcga agtaggagtt cccctcgttg accgcgagga
    10921 acgaactcgg attgtcggac tcggcgtgaa tgctgatcat ttcgaggacg tagtccaggg
    10981 acgggtgttc gcgcatgccg ccatcatctt ccggcggaac acggcgttca attccccgtc
    11041 cgcgtttttc tcgggattgt cagcggggca tcagcatcag cgatcggtag gtcgaccgtc
    11101 acattgccgt gccatgctct cgtccgagcc gagagaatac ggaggacgca tccatgcgat
    11161 cgctcgacat cgcccgtgat tcctgtgagc ggctgcaccc cggaatgatc aagtcgttcc
    11221 tggaggtccc cctcatggag cgcgaggcca aggggagttc cgtggtcgag gtcttccgca
    11281 ggcacggcgg gccggggctg ctggtgccgg ccgcctacgg ggggctcgga gcgagcgccc
    11341 tcgacgcggt ccgggtgacc cgggcgatcg gcgcccactc cccgtcgctg gccgcggcct
    11401 ccgcgatgca caacttcacc gccgcgctgc tgttcgcgct cgccgagcgc gtggtgccgc
    11461 cggggccgga gcaggcgcgg atcctggcgc ggatcgcgcc ggagggcatg ctgctcgcct
    11521 ccggctgggc cgagggccgg acccagcagg acatcctcga cccggtgatg acggccgaac
    11581 cgaccgagcg gggcttcctc gtcaacggct ccaagaagcc ctgctcgctg gcccgttcca
    11641 tggacctgct gaccgcgagc accatcctgc ccgacgatga cggcggaacg tcgctggtgc
    11701 tgctgctcat ccccgcggac tccccgggca tctcggtgca cccgttctgg gacagcccgg
    11761 tcctcgccgc ggcgcagagc gacgaagtgc ggctggagaa cgtccacgta ccggagcggc
    11821 tggtcgtccg gggaaccgcc gacgaccccg accggctcga cgacatccag agcggcacct
    11881 tcgtctggtt cgaactcctg gtgacctgcg cctacgtcgg tgccgcctcg gccctgaccg
    11941 agatggtgct gcagcgcggg cggggcagca cgaccgaccg cgcggcgctg gcggtcctga
    12001 ccgagtcggc cgtgctcctc acggagggca ccgcgcgcgc ggtggacgcc gggctggccg
    12061 gcgaggacgc cgtggcggcg gccctgacca cccggttcgc cgtgcagcgg gcactggccg
    12121 ggatagccga ccaggccgcg gagctgctcg gcgggatcgc gttcatccgc gagcccgaga
    12181 tcgcctacct ctgctcggcc ctccagccgc tcgccttcca cccgccgggg cgcaccagtt
    12241 cctcccggca cctgatcgac tactacaacg gcggagcgct gcggatctga ccgtccggct
    12301 ccgagccacc cgcagggagt gcccacccat ggaccaagcc aacgccttcg agtcaccgac
    12361 caccatgcgc ctgcaccgcg ccgagtacct cgcggccttc gccgtctccg tcgggctgtt
    12421 cgtcgcccac gccgaccggg tccgctggct gcccgcggtc ctgctcttcg tctacatcga
    12481 cgtgatcggc tacctccccg gggccgtcgc ctaccgccgg acgcccggcg gccggatctc
    12541 caagaactac taccgggcct acaacctgat gcacagcgcg ctgacccagg gactggtcgc
    12601 cggcgtgtgg atctgggcct ggggagcgga atgggccctg ctcgccatcc ccatccacct
    12661 gtgcgcggac cgcgggatct tcgggaactt cctcaagccc ctggccctgc ccttcgagcc
    12721 cgtgcccgac cagcggttcg ccgagttgac cgcgcggctc ttcccccgcg ggacgcgcgg
    12781 ggggaatccg gcccggactc cggagagcgc gacgtgacgc ggccgtcggg acaggctccg
    12841 gcggccaccc cgcacgccgt ctcccgccgg ctcaccaccg gcgtgtcggt cctgacctcg
    12901 gcccacggcg gctcggtgca cgcggccacg gcgagcacgg tcgccgtcct ctcccagcag
    12961 ccgctgacct tggccgtctc gctgcgccgg aactcggtgc tcgccgaact cgccaccctg
    13021 tcggggtact tcgtcgtcaa cgtgctcacc tcccggcagg cggtgctcgc cgactggttc
    13081 gccttcccgc gccggccgcg gggacgcgcg cagttcggcc cggtggactg gcgcaccgac
    13141 accgccaccg gcatcccggt gctgacggac cacctggcgc tgctcacctg ccggatcgtc
    13201 ggccggacgg cggtgggtgc cgacgacgac ctgatcatcg ccgaggtgac cgcggcggaa
    13261 gcaggccggg gcaaccccct ggtcaactac gacggccgcc tgctcgaccc cgagttcaac
    13321 gccgtcgtcc gccggcccgg atggcgcccc cgcgcccacg aacccgtcct cgactaggag
    13381 gagcacgatg tccgcaccga tccccgcgga aaccggatgg gactccgccc ccggtctcct
    13441 ggagggggcg atgaccctcg acctcacccc ggagcagtgc gacctcgggt actggctgcg
    13501 cggcgtcgcc cagggcaccc tggccggacg cgccgagacc ggtcacaccg acgccgagcc
    13561 gacgccggag cacatgcggg ccgacggacc gctgcgcgac gcccaggtcc tggagctgtc
    13621 ctgccgctcg gtggcggagg cgcaggccac ccgggtcctc gcccactacg tggcgcaggc
    13681 tccggacatc gtcgagctgg agttcttcac cacccagctg gtcgacgagg cgcggcactc
    13741 catggtgttc cgccggcacc tgctcgccat gggcgtgccc gcggaccggc tgcacgcgag
    13801 catcgccgag gtctccgccg agtaccggcg cgaggtcctc gaaccgatcc tcgacttcgc
    13861 cctgaccacg gtcagggacg aaggggactt cgtcgggggc gtcgccgtct tcaccatcat
    13921 catcgaaggc gtgctggcgc cggccgccga gctgagcgag cgcaagtgga acctgctcga
    13981 cccggccgcg ggggccatcg cccgcggtgc cgcgatcgac gaggtccgcc acctgacggt
    14041 cggcagctcc gtggtgcgcc ggcacctgct gcggcggccg gagcgcaagg cggcgctgct
    14101 cgacatcgtc cgccgggggc gggagatctg ggacggcatc cccgaccgca agcacgtcct
    14161 gcgccgcgag gagctgttcc aggccgggat gcgggagcac gccgacctgc tggccggcta
    14221 cgaggtgtgg cccggccagc ccctgctgtc gaccaccccc gagcagcgct acgccatggc
    14281 ggagcagtgg accgaccgga tggcggcggc ccgcctggtc cacatgggcc tgcccgaggc
    14341 gatcgacctg ctgcgcctga ccgactgagc cgacgggcac gacagagccg gaccaccggc
    14401 aggaaggaac accgatggcc gcccttccca cgggcatacc gttcggaccg gacgacgctg
    14461 cctggagcac gggcctcgac cggctgcgca ccgccggcgc cacccgggtg tccgcaccca
    14521 gcgcggatcc gcgcgagacc tacccccagc tgccggaact accgccggga aggttccagt
    14581 tgcccgcgcg cggcctggac gcgaccgagt acgcccaggc cgaggacctc ttccgccgct
    14641 acgtcgagga ccactcctcc cgcagcctcg gctaccagct gcactggtcc gaggacttcg
    14701 cccgcaggct cgcgccctac ctcgggctcc agctgaacaa catcggggac ccgtaccagc
    14761 acggcgcgtt catgccgaac tcgaaggtgc tggaacgggc ggtcctcgac tacttcgcct
    14821 cgctgtggaa cgccaagtgg ccgcaccggg ccggggaccc ggagtcctac tggggctacg
    14881 tcctgaccat gggagccagc gagggcaaca tccaggccct gtggaacgcc cgcgagtgcc
    14941 tgtccggcaa accgctggcc gggcagccgc gcctcccggc ggacaccgcc cacgagaacc
    15001 cgaacgcgcg gcacccggtg gtgttcttca gccgggagac gcactactcg ctcaccaagg
    15061 cggtcaacct cctggggctc gacaccttcc acgcgctggg cagcagccgc tatccggacg
    15121 ccaaccccct gggccccggc accgagtggc ccaccgaggt cccgtgcgtc gggggcgtcg
    15181 acgggcccgg cgccatcgac gtggagaagc tgtccctgct ggtgcgcttc ttcgtccgcc
    15241 ggggacaccc ggtgttcgtc aacctcaact acggctccac cttcaagggc gccttcgacg
    15301 acgtgcccga agccgcccgg gcggtgcacg agatctgcgc cgagtacggc atggccgaac
    15361 ggaccttccc ctccgaccgg gaagggaccg gcgccaggcc ccggcccggc tactggatcc
    15421 acgtggacgc cgcgctgggg gccgcctacg ttccttacct gcggatggcc cgagcggccg
    15481 gcctggtcga gtcggcaccg ccccccttcg acttccggct gccgcaggtc cactccctca
    15541 cggtgagcgc ccacaagtgg atgggcgccc cctggccctg cggcgtcttc atgacccgca
    15601 acgggctgcg gatgcccccg ccgcgttcct ccgagtacat cggcggcacc gacacgacgc
    15661 tgtcgggatc gcgcaacggc ttctccgccc tgctgatgtg ggactacctc gcccaccact
    15721 cctacgacga cctggcccgg caggccgccg agtgcgaccg cctcgcccgg ctggcccacg
    15781 agcggctgtt gaagctgcag agcggcctcg gcgtcgacct cctcgtctcg cgcagcccgt
    15841 ggtccctggc cgtgcgcttc cgccgcccgg acgaggcgat cctgcgccgc tactcgctgg
    15901 cgtacgagac gctcctggtg gacggtgtgg agcgccccta cgcccacctg tacgtggtgc
    15961 cgcacgtgac cgagggcctg atcgacgcgc tgctgcggga cctcgggcag ccgggggcgt
    16021 tcgccggggg agcggcggca tgagcgctcc ccgccggccc ctgcggttcg gcgtgctgct
    16081 gccgaccagg gaacaggccg tcaccgggcg gtacgacgcg ggggcgctgc tggccttcgc
    16141 ccggcgggcc gaggagctgg gattcgattc gctgtgggcg ggcgactccc tgaccgcccg
    16201 cccccgtttc gaccccttgg tcaccctgtc ggcggcgggt gccgtgaccc ggcgcgtcac
    16261 gctgggcacg gccgccatga ttcccgtcct gcgccacccg ctgatcgggg ccaacatggt
    16321 cgccgcgctg gaccacgtct gcggggggcg gctgacgctg gggctggggg cgggcttccc
    16381 ccttccggag accgaggcgg agttctccgc cgccggggtc gagtacgccg cgcgcggccg
    16441 actgctgcgg gagacggtgt cccgctggcg cgaggcgtgg gcggcctccg gtgccgaggc
    16501 cggaccccac ctcctgccgc cgcccctgcg cgcggggggc ccgccgttgt ggctggccgg
    16561 cagcgacacg ccgcgggtgc tgcgccgagt ggccgccacc tacgacggct ggctcccctt
    16621 cctcccctcc gccgacgcct accggcgggc ctggcggcgc gtcggggagc acctggacct
    16681 ggcgggccgg ccgcgcggcg aggtggtgcc ggccctgtac gccaccgtca ccctcgcggc
    16741 ggaccgcgcg cgggccgcgc gggagatgga cggctacctg ggtcgctact accggcgctc
    16801 cctggcggag atgtccgcct tccagctgtg cgtaccgggc ggggtcgagg agtgcgcgaa
    16861 ggagctcgcc gagttcgccc tcgccggtac cgagcacttc gtcctgcgcg tcggctccat
    16921 ggacttcgcc ccgcacctcg aacggatcgc caccgagctg ctgccggcgg tccgcgccct
    16981 cgtcgatccg accggatgaa cacccgaacc tccccccgac ccgagaggaa caccatgacc
    17041 acctaccgga acgcggaaga acggcacacc agcggcctgg ccaaactcga ggaggtggcg
    17101 ggaaccgagc tcaaggagcg gttcctggag aacctccgga acgtgtcccc cgagttcagg
    17161 gactacgtct ccgacttcat ctacggcgag atctacagcc gcgagggcga actggacctg
    17221 ttggagaagg agcaggtcac cctggtcacg ctcgccgccc agggcggtct ggactacgag
    17281 ctccgcctgc acctgcgggc cgccctccag ttggggatat cgcccgcccg gatcgccgac
    17341 ctgttcatcc agatgagccc gtacgccggc ttcccccggg gcctgagcgc gatcctctgc
    17401 ctcaaggacg ccctgtccga cgtcaccacc gccgagttcg tccgggaaca ccgccggtag
    17461 cggtgcccga accgtccgag gaggacagat ggtgttcatc cggtcgagcc gcttcgcgga
    17521 ggtcaggtac gagatccgcg ggccgctgag cgaggaggcg cgggtgttgg aggaggccgg
    17581 caggaccgtg ctccggctga acacggggga cccggcggcc ttcggcttcc gtccgccgcc
    17641 cgccttcctc gccgaggtgc tcctcagggc ccgccacagc aacggctaca gcgacgcccg
    17701 cggactcctg gagtcccggc aggcggtggc cgagtggtac cgcgcccagg gggtggcgga
    17761 cgtgggcgcc ggggacgtgg tcctgggcaa cgggacctcc gaactgatcg ccatggccct
    17821 ccaggcgctc ctggagccgg gggacgaggt cctggtcccc tcccccgact accccgcctg
    17881 gacggcgaac acctccttcg cctccgggcg cccggtgcac taccggtgcg acgagtcggc
    17941 cggctggctg cccgatctcg acgacctggc cgcccgggtg acctcccgca cccgggcggt
    18001 ggtcctcatc aaccccaaca accccaccgg tgcggtctac ccgggggaga ccgtcgaggg
    18061 cgtgctggag atcgcccgcc ggcacggcct gatggtgctg tccgacgagg tctacgaccg
    18121 gatcctgtac gacggggcgg tgcaccagcg cccggccgcg ctgggccccg acgtggtctg
    18181 cctcaccttc ggcagcctgt ccaagtcgta ccgggtcgcc ggcttccgcg ccgggtgggt
    18241 ggtcctgtcg ggtcatcgga gcagcgcccg ggactacttc gaggggctgc tggccctggc
    18301 gtccctgcgg gtgtgcgcca acaccctggg ccagtgcgcg gtggaggtcg ccctcgccga
    18361 cccggagtcc cgggggaccc tcaacctggc ccttcccggg gcccggctgc accagcagcg
    18421 cgaacaggcg tggaaacggc tgaccgccat ccccggggtc agctgcgtca agccgatggg
    18481 ggccgtgtac gccttcgccc ggctggaccc ggaggtctac aagatccacg acgacgggcg
    18541 gctggccctg gacctgctgc ggagcaagcg ggtccagatc gtgcagggca ccggtttcaa
    18601 ctggcccgcg cccgaccact tccggatgct cacgctcccc cgtgtcgagg tcatcgacac
    18661 cgccgtcaac cgcatcgagc ggttcctcgc cgactacgtc caatgaccgg cgaccgcctt
    18721 cccgaccctg gagcgcaccc gtgaacgacc ccgcctttcc ggcctacgac gacgtcgagg
    18781 ccgccgccag gcgcatcgcc ggcgtcgtgc gccgcgtccc ggtcgtcgcg ggggacgccg
    18841 acgccttcgg cggctccgag gtgtacctgg tgcccgagtt catccagaac tccggctcct
    18901 tcaaggaccg cggcgcggcc aacttcatcg ccgcgcacct ggagtcgggc acggtgcccg
    18961 aggccggcgt ggtgatcgcc tccggcggga acgcgggcct ggcgtgcgcc tgggccgccc
    19021 ggctgcacgc ggtccgggcc acggtcttcg tgcccgagac cgcgccgcgg gtcaaggtcg
    19081 ccaagctcct cgcgtacggc gcggaggtgc gccgggtcgg caccgagtac gcccacgcgg
    19141 cggccgcggc ggccgcgttc gcggacgcca ccggcgcgct cccctcgcac gcctacgacg
    19201 atccccacat cgccgccggc gccggcacgc tcctgctgga gatcctcgac caggtccccg
    19261 ggctcgacag cgtcgtcgtg gccgccggag ggggcggcct gttcaccggg accgccatca
    19321 ccgccaccac ccacggcgtc cgggtcgtcg ccgtcgagcc ccgtacctgc cggtgcctga
    19381 acgccgccat cgaggccgac gcggtggtcg acgtggcggt cgactccgtg gccgccgacg
    19441 cgctgggcgc gcgtcgcgcc agcgagatgg cgctgcactg ggcgcgcgcg tccggcgccg
    19501 actcgctcct ggtgcccgac gagacgatcg tcgcggcccg tcggaccctg tggcagcgct
    19561 accacttcgg cgtcgagcac gggggagcca cggccttcgc cgccctgctc tccggtcgct
    19621 acgccccgga acccggcgag cgggtggcgg tcgtcctgtg cggggcgaac accgatccga
    19681 cggacctcgc caccgacccg cccgaccccg cgggccccgc tcccgccccg gcgcccgcgt
    19741 gaagcgcgcc ggcgccgacc gctcgacgcc gcgaagagcc tcggcagccg gggagaccgt
    19801 gcgcccggcc gcccgccacg ccccggagcg gcccccgtcc cctttccccg tcgctccttc
    19861 cgggagtccg catgaccgcc tccgaaccgc ccgcccgtga cgggcggctg gtgcgcaccc
    19921 tcaccactcc gaagatcgtc ttcatcatca tcgccgccgc cgcaccgctg gccgcgatgg
    19981 tcttcaccgt gccgctcgcc ttctcgatcg gcaccgggcc gagcgtgccc gcgctcttcg
    20041 tcttcgccgg gctgacgctg ctctgcttca cctccggcta cgccgccatc agccgccgga
    20101 tcagccacgc cggcggcttc tacacctaca tcgcggcggg cctcggccgc cccgtcgccg
    20161 tggcgggcgg tctgatcgcg gtgatcgcct acaacaccgt gaccatcggg ctgctcgggg
    20221 cgttcgccta cttcgcgcac agcgtcaccg cctcgtacgg cctcgacgtg ccctgggagg
    20281 cgtgggcggg cgcggggctg ctgtccatcg gcgtcctcgg ctaccgccac gtggagttca
    20341 gcgcccgggt gctctcggtc ctgatggtgt gcgagatggc ggtgctcctc gcgctcgacg
    20401 tcgccgtgct ggcgcaccgg ggtctggccg cgctgcccgc gcagtccttc tcccccgggc
    20461 tgatcgccgc ccccggcctc ggcgtgtcgg tgatgttcgc cttcgcctcg ttcatcggtt
    20521 tcgagtcggc ttcgctctac ggggaggagg cccgcgatcc cgggcggagc gttccgcgcg
    20581 ccacggtcat cgccgtgctg ctggtcgccg gcttctacgc gctgaccagt tgggtggccg
    20641 tgggcgccgt cggcccggcg aacgtgcgcg ccacggcgtc cggccacctg gacgacctct
    20701 tcttcgacct gggcgacagc tatctcggcg gcgtgacgag cacggtcatg caggtgctgc
    20761 tgtgcacgag cctgttcgcg gggtggctgg ccctgcacaa cgccgcgaac cggtacatgt
    20821 tcgtcctcgg gcgtgaccgg gtgctgcccc ggtggctgga cgcggtccat ccccggcacg
    20881 gggcgctgca ccacgcgtgc gtcgcccaga gcgtgaccag cgccgtcgtg gccgccttct
    20941 tcgcggcggc ggggatcgac ccctacctgg gaatgtccac gagcatgctg ggcctcggca
    21001 cgctcggcgt gatcgccctg caggcgctcg cgtcgctctc cgtcctgggc tactaccgcg
    21061 ggcggcggcg ggggcactgg tggcggacca ggatggcgcc ggccctcggc gcggtcggtc
    21121 tggtggccgc ggcggtcctg gtggtgcgga acttccccgt cctgacgggg acgaccaatc
    21181 ccgtggtgac ggccctgccg tggctgctcc ccctggccgg cgcgatcggg gtcggccacg
    21241 cccaccggat gcgggccagg cacggcgagc ggtacgcggc cctggccggg gtggagcacg
    21301 ccggccgcgg cggggcggcc cgcccggacg gccgggactg acggggtccg ctccgcgcgc
    21361 gccccggggc ccgccccgct cccccggggc cggcccgacc gggtcacctc acgccaccgt
    21421 ccggggcgat gacctcgaag ccggtgtggg ggaccagtgc ggcggggacg gcgaccgagc
    21481 cgtcctcgcg ttggaactgc tccaggagcg ccgccatggt ccgtccgatc ggcagccccg
    21541 aaccgttgag cgtggccgcg aactcgttgg cccccgcggt cttcaccttg atgccggcgc
    21601 gacgtccctg gaaggtgccg cagtcactga ccgaggagat ctcgcggtac ctctgctggc
    21661 ccgggagcca gacctccagg tcgtacgtgc ggcgggccga gaacccgagg tcaccggtgc
    21721 gcagctcgac cacccggtag tgcaggccca acctgcgcag tgcctcctcg gcgtgcccga
    21781 ggaggacctc gtgctcgtgc cgggcgtcct gggccgcgca gaggcggacc agctccacct
    21841 tggcgaactc gtgcaggcgg atgacgcccc gggtgtcccg gccgtaggaa ccggcttcgg
    21901 agcggaagca ggcggtgtgc gcggtcaccg cgagcggcag cgcggcggac gacagggtct
    21961 cgccccggaa caggttgacc agggggacct cggccgtggg gatcaggaag agctcgcgct
    22021 cggccgcccg ggtgccgaac aggtcgtcgg cgaacttcgg gagctggccg gtggccgtca
    22081 tgctctcgcg ggtcaccagg tgggggacgc tcatctcgac gtagccgtgc tcgcgcgtgt
    22141 ggaggtcgag caggaacgag gcgagcgcgc gttcgagcct cgccccggct ccccgcagga
    22201 cggcgaagcg cgccccggag acccgccccg cccgttcgag gtcgaggatg ccgctgcccg
    22261 cgccgagcgc cacgtggtcg cggggggcga agccgaactc gggccgggcg ccccactgcc
    22321 gcagctcgac cgccgcctcg tcggcccgac cgggcggcac gcactccagc ggggtgttcg
    22381 gcaccgcgag caggaagtcg cgcagccgct gctccgcctc gcggagctgt gccgcgaggt
    22441 cgccggcgcg ctgccgcagg tcgcggcctt cggcggcgtc ctcctgcgtc gccggccggt
    22501 gccggcgggt ggtgatccgg atggccgcgt gcagggcgtc ccgttcggcc accaggcggg
    22561 aacggagtgc ggcgagctcc gcgagggagt cggcgtcgag ccggtacccg cgccgcgcga
    22621 gcgcggtcac ggcctccggc gagagcaggt cacgcagagg gtgcacggat tgcctcctgg
    22681 agggagcggc gtcccgcgaa ggtcgcccgc tgggatcgga tcgtgtgccg tcgcgatggg
    22741 gcaccggtgc gcgggagccg cgcggccggg tggggagggt ggtggcgcgg gccggtctcc
    22801 cccgggggcc gggggggtgg tgggggtggt gatcgcgttc cccgggaggg gacttccgcc
    22861 aggggaggtg ttcgcgcgcc cggcccgcgc cggaaggcgc ccgcgccggg ccgcctccgc
    22921 cgcgtcgcgc ggcgacgggt gccactcgcc ggaggggccc gcggtggaaa cgaccgtgcg
    22981 ttcccccgtc ccatgctgcc cggtgcccct gacgcgctgc tgactgcggg gtgacaccgc
    23041 cgcccggccc gtccgccggc cgctccgcgc atccggccgg tccggcatcg cctcggcggt
    23101 ggccctcccg tgccgcggcg ggccgtgctc cttaactccg ccgccgaact gaacagaagt
    23161 ccgttcgaaa cggcttgcca tctggtgttc gaatggcgga ccgtagcggc tgggcgcact
    23221 gtccgtcagg gggccgacgg aggcagcgcc cgatctcctc gaagcacgtg cgtgtgctcc
    23281 ggtcccgctc gtggtgcgga ccgagcggga ccgcgcccct ggggacgggg gcggcggagc
    23341 ccgggcggcc gtgggcaaac ggcctccacc cgggcgacgg gacgactccc gcgaccggac
    23401 cggccggtgg tcaccgcctg cggggaccgg gccctccgga gcggacggtg cggcacccgc
    23461 ccgaccgtgc gtccggtcgt cgcgggacgt cccgccggag tctcccgacc cacgggcccg
    23521 ccgaccgggc cgccggtcgt gttcgatcgc ccaccccgag ggagcgggcg gggttcccct
    23581 cccctgcgcc ctgccttccc gacagcacgc accgacgttc cgacaaggga gttgctgtgc
    23641 ttttcttcag gatcctggga cccctcgaaa tcggagcccc cggagacgcg tggcagccga
    23701 acggagggcg ccaggccatc ctcctgtcgt ccctcctggt gagcgacggc catttcatga
    23761 ccaccgaggc cctggtcgac gagatctggg gggacagccc gccgtccggc gcgctgaacg
    23821 ccttgcaggc ccaggtcagc cggctacgcc ggcggctgtc ctcgctgtcg tccggatccg
    23881 tcaggttggc cgcgctgtcc ggcggttacc tcctcgacat ccggagcagg gacctggacg
    23941 cctcggtgtt caccgagggg ctcgaacggg tccggacgaa ggcggcgggc gggaccttgc
    24001 actcgtccga ggtggccgac ctgctcaagc tgtggcgcgg gcccgtcctg ggcgggctga
    24061 ccggaggaag cgtctgcgcg gccgcgacga ttcggtacga ggagttgcgg ctgcacgcgc
    24121 tggagttccg ctacgagtgc gagatcgacg agggcggtcg ccccgacatc atcgccgagc
    24181 tgaagggcct cgtcgccgcc cacccctacc gggagcgctt cctggtgcag ctcgtggtgg
    24241 cgctctgccg ggtggggcgg caggccgacg ccctccatgc ctgccggcgg caccgcgcgg
    24301 tgctgctgca ggacctgggg atcgacccgt caccgaccgt gcggaagctg gagcacgcca
    24361 tcctgcac
//
