LOCUS       NC_016109              24784 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Kitasatospora setae KM-6054, complete sequence.
ACCESSION   NC_016109
VERSION     NC_016109.1
KEYWORDS    RefSeq.
SOURCE      Kitasatospora setae KM-6054
  ORGANISM  Kitasatospora setae KM-6054
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Kitasatosporales; Streptomycetaceae; Kitasatospora.
REFERENCE   1
  AUTHORS   Ichikawa,N., Oguchi,A., Ikeda,H., Ishikawa,J., Kitani,S.,
            Watanabe,Y., Nakamura,S., Katano,Y., Kishi,E., Sasagawa,M.,
            Ankai,A., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Nihira,T., Horinouchi,S., Ohnishi,Y., Hayakawa,M.,
            Kuzuyama,T., Arisawa,A., Nomoto,F., Miura,H., Takahashi,Y. and
            Fujita,N.
  TITLE     Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
            snapshot of the family Streptomycetaceae
  JOURNAL   DNA Res 17 (6), 393-406 (2010)
   PUBMED   21059706
  REMARK    DOI:10.1093/dnares/dsq026
REFERENCE   2  (bases 1 to 8783278)
  AUTHORS   Ichikawa,N., Watanabe,Y., Nakamura,S., Katano,Y., Oguchi,A.,
            Ankai,A., Yashiro,I., Fukui,S., Hashimoto,Y., Kamata,S., Otoguro,M.,
            Tanikawa,S., Ikeda,H., Ishikawa,J., Horinouchi,S., Ohnishi,Y.,
            Hayakawa,M., Nihira,T., Kitani,S., Kuzuyama,T., Arisawa,A.,
            Nomoto,F., Miura,H., Takahashi,Y. and Fujita,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2009) Contact:Director-General Department of
            Biotechnology National Institute of Technology and Evaluation, NITE
            Genome Analysis Center (NGAC), Department of Biotechnology; 2-49-10
            Nishihara, Shibuya-ku, Tokyo 151-0066, Japan URL
            :http://www.bio.nite.go.jp/
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000269985.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 11:32:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,713
            CDSs (total)                      :: 7,605
            Genes (coding)                    :: 7,487
            CDSs (with protein)               :: 7,487
            Genes (RNA)                       :: 108
            rRNAs                             :: 9, 9, 9 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 9, 9 (5S, 16S, 23S)
            tRNAs                             :: 78
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 118
            CDSs (without protein)            :: 118
            Pseudo Genes (ambiguous residues) :: 0 of 118
            Pseudo Genes (frameshifted)       :: 25 of 118
            Pseudo Genes (incomplete)         :: 95 of 118
            Pseudo Genes (internal stop)      :: 9 of 118
            Pseudo Genes (multiple problems)  :: 11 of 118
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:33:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 536144
            Orig. end                         :: 560928
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP010968.1.
            'Otoguro, M. is at NITE Biological Resource Center (NBRC). Ikeda,
            H., Miura, H. and Takahashi Y. are at Kitasato Institute for Life
            Science. Ishikawa, J. is at National Institute of Infectious
            Diseases. Horinouchi, S., Ohnishi, Y. and Kuzuyama, T. are at The
            University of Tokyo. Hayakawa, M. is at University of Yamanashi.
            Nihira, T. and Kitani, S. are at Osaka University. Arisawa A. is at
            Mercian Corp. Nomoto F. is at Nagase & Co. Ltd. The other authors
            are at NITE Genome Analysis Center (NGAC).
            Please visit our web site. URL:http://www.bio.nite.go.jp/
            DOGAN ; Database of Genomes Analyzed at NITE. The database contains
            genome sequence data, physical maps and the genomic and proteomic
            data of the microorganisms analyzed.
            URL:http://www.bio.nite.go.jp/dogan/Top
            The microbial strain and microbial genomic DNA clones used for the
            sequencing project are available through the NBRC.
            URL:http://www.nbrc.nite.go.jp/e/index.html.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24784
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24784
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24784
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14784](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14784
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(520..1485)
                     /locus_tag="KSE_RS02255"
                     /old_locus_tag="KSE_04670"
     CDS             complement(520..1485)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133633.1"
                     /locus_tag="KSE_RS02255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04670"
                     /product="acetylxylan esterase"
                     /protein_id="WP_014133633.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.8e-09, bitscore:
                     35.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAFLSMNLSELREHRPARTEPDDFAAFWAGTLAEARAVPARLDTV
                     AVETGLATVTVEDVTFPGYAGQPIKGWLVRPRGAGGPLPAVVSYVGYGGGRGLAHEHLL
                     WASAGYAHLVMDTRGQGGGWAVGDTSDEAPSAGPAHPGSMTRGVLDPAAYYYRRLYTDA
                     VRAVDAVRTHPGIDPERVLVAGSSQGGGLALAVAGLVPDLAGVVAEVPFLQHIRRATEI
                     TDAFPYKEVADFCKVHRDKVETVFATLAYVDGLHFAARATAPALYSVALMDEVCPPETV
                     FASYHHYRGPKEIAVYPYNGHEGGGAHHVPAMLAFAAKVL"
     gene            complement(1672..2883)
                     /locus_tag="KSE_RS02260"
                     /old_locus_tag="KSE_04680"
     CDS             complement(1672..2883)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133634.1"
                     /locus_tag="KSE_RS02260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04680"
                     /product="serine hydrolase"
                     /protein_id="WP_014133634.1"
                     /transl_table=11
                     /translation="MNEHPPRRTARRIRAVRHAMTATAAAGLALTALVPTSASASASAS
                     AAPAAAPRPDVVQQRLDALVKADGMPAALATVKGRDGRSRTYTAGVGDLATGAGVPVDG
                     QIRAGSNTKAFTAVVVLQLVAEGRVGLDASVDTYLPGLLRGDGVDGRNITVRQLLQHTS
                     GLPDYMLAPALLDFTTIQYRYFEPRELLDGALAQRAVFAPGTGWGYSNTNYLVAGLLIQ
                     KVTGRPYAEEVTRRVIDRIGLRHTYLPATGETALREPHPHGYLNTGDTGEPASGARLVD
                     YTEMDSSMAWAAGAVVSTNSDLNAFYGALLGGRLLPAAQLAQMRSTVPAELLGPGVRYG
                     LGIQSRPLSCGGLVWGHGGTAPGHRSRGGVTEDGRAANITVTTVPEPPAAEHVTDAVDA
                     ALCR"
     gene            complement(2940..4178)
                     /locus_tag="KSE_RS02265"
                     /old_locus_tag="KSE_04690"
     CDS             complement(2940..4178)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133635.1"
                     /locus_tag="KSE_RS02265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04690"
                     /product="serine hydrolase"
                     /protein_id="WP_014133635.1"
                     /transl_table=11
                     /translation="MNENALRPHRAHRLREDRQTDRPTGRRTDRRTGRRPGREAGRGVT
                     AVTVAALAAAVVAGVLAPGSASAAPRPDATRQRLDALVKADGVPGALATVKGRDGRSRT
                     YTAGVGDAVTGAKVPVDGQVRIGSNTKAFTAVVVLQLVAEGRVGLDASVDTYLPGLLRG
                     DGVDGRNITVRQLLQHTSGLPEYVDTEGVLADPGRYFEPRELLDAALARKAHFAPGARW
                     EYNNTNYLVAGLIIQKVTGRPLGEEITKRVVDRIGLRHTYFPAPGETTIREAHPKGYLR
                     AADGSLRDYTKLDPSWGWAAGAMVSTNSDLNAFYGALLGGRLLPAAQLAQMRSTVPAEL
                     LGPGVRYGLGLISRPLSCGGVAWGHGGALPGYETFGGTTDDGRAASIAVTGFPAGEEVG
                     KHADQAVDEALCG"
     gene            4465..5805
                     /locus_tag="KSE_RS02270"
                     /old_locus_tag="KSE_04700"
     CDS             4465..5805
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025639.5"
                     /locus_tag="KSE_RS02270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04700"
                     /product="PD-(D/E)XK nuclease family protein"
                     /protein_id="WP_014133636.1"
                     /transl_table=11
                     /translation="MSTDIDGHGVTPARPPGVADRPAPHLRVPDVTPAPPTGGPNPPPR
                     PPWWEENVGAGRWAGVEADLLALPRSRRADRSPTPLQILGARRRESSHEHYLAFLLDPR
                     EDHGLGAGLLAALLELAGRPDLAADPRLDRTRLHRQVSGDASRPDLVATGPAASVVVEL
                     KIDAPEGHRQTTRQADDFAGLAQSAVFVYLTPDGTAPGDGRFRPVAQRDLAGRLARLLA
                     RTSTGPDAAGPDGAGPGAAGRRHAEDYLNDLEAVVGISTDDDEDARFWATHRTALLAAQ
                     AATRRLLTRLPAHTGVALAALADGLGADLVVGHVDYTTSGGHAESAVVLSRPGWLADGV
                     PQLGFGLGIRRRSGGTQGPDLDGAAQHPFHGIYCTHPAVRAELGRRLAHRGWGGHWAWW
                     QYAELTPQPAGTGFLDHNAANVGAAVRDSWLDHIAAVDALWAARHTL"
     gene            complement(6206..6661)
                     /locus_tag="KSE_RS02275"
                     /old_locus_tag="KSE_04710"
     CDS             complement(6206..6661)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS02275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_04710"
                     /product="hypothetical protein"
                     /protein_id="WP_033260223.1"
                     /transl_table=11
                     /translation="MRIKRTAAVTMAFLSVALGGAVAGATTAQAAVPAKFPRVHCSTTK
                     IEVRSLDVAGGPVKCGGALGDPLYCTINGVDHVFAVGTDNAMWARWISPSGVPSDWVSF
                     GGSLTSEIRLYADGSGSLDFSARWSDGHLYEITRNDNGSWINWRRVD"
     gene            6810..6950
                     /locus_tag="KSE_RS42635"
     CDS             6810..6950
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS42635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157850107.1"
                     /transl_table=11
                     /translation="MVVAVEAPARTAPGRRRTARQRTDTDTDTGATATATATATDRNPN
                     A"
     gene            complement(6973..7653)
                     /locus_tag="KSE_RS02280"
                     /old_locus_tag="KSE_04730"
     CDS             complement(6973..7653)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1258: Antibiotic biosynthesis monooxygenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF027615.5"
                     /locus_tag="KSE_RS02280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04730"
                     /product="DUF4937 domain-containing protein"
                     /protein_id="WP_014133638.1"
                     /transl_table=11
                     /translation="MWGKWIGCRVPVAARGRFATAQAAWPAIGDQPGLLGQVGGWDPDG
                     GGALLLGLWADEGAYLRFMRDRHAAVAADSRRSADERHGRAGSGAGYTAIDAAAGEVVL
                     DMPGDAAGLPQALERAALLRVADCRLAPGRGRHFLDVQREVWAPGMAAAGGMLAGVVVR
                     LGEDRHLVATLWSDPAAHRRYADRHLPALRARAVPEDDLRSVSGGALPLEPAWRVLPTG
                     RPRR"
     gene            8196..9146
                     /locus_tag="KSE_RS02285"
                     /old_locus_tag="KSE_04740"
     CDS             8196..9146
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019619.5"
                     /locus_tag="KSE_RS02285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04740"
                     /product="JmjC domain-containing protein"
                     /protein_id="WP_014133639.1"
                     /transl_table=11
                     /translation="MLTELTGDADAFAKAVAEGIPQVFRPTGRPAGLPGVEELETVLNG
                     GLLRVPYVEMVRDGAVVEPELFCATRTVAGRRESGWADPARISALLAEGATLLLPQLDQ
                     WHAGVRAMATDIALHLGRRTEAFCFTTGAGRRGLDVHRDDADVLVVQLAGAKDWTVHEP
                     PADGHWRPGLAPAPGPVALRTALTPGEILYVPRGAPHTATGHRGLSVHLSFTIREATTG
                     RLHAALGEFLTTPGLPTGDLPERPDTSEVLATAAEVLRLGRERLAALTPEELLQLARGP
                     LPAGAAAAPGATSLAGAGLAGAGLLGVEWGMRDTA"
     misc_feature    complement(8242..8256)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.71"
                     /tool="antismash"
     gene            complement(9567..9698)
                     /locus_tag="KSE_RS45575"
                     /old_locus_tag="KSE_04750"
     CDS             complement(9567..9698)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KSE_RS45575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KSE_04750"
                     /product="hypothetical protein"
                     /protein_id="WP_014133640.1"
                     /transl_table=11
                     /translation="MATDMQELFDLDVQDLVAAESPEHEEAAVSLSCEGSCTRPFCI"
     CDS_motif       complement(9615..9698)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MATDMQELFDLDVQDLVAAESPEHEEAA"
                     /locus_tag="KSE_RS45575_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9567..9614)
                     /prepeptide="core"
                     /locus_tag="KSE_RS45575_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="0.20"
                     /molecular_weight="1529.8"
                     /monoisotopic_mass="1528.7"
                     /core_sequence="VSLSCEGSCTRPFCI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MATDMQELFDLDVQDLVAAESPEHEEAA"
                     /leader_location="[9614:9698](-)"
                     /alternative_weights="1547.8"
     misc_feature    9661..9676
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.03"
                     /tool="antismash"
     gene            10001..13552
                     /locus_tag="KSE_RS02290"
                     /old_locus_tag="KSE_04760"
     CDS             10001..13552
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="KSE_RS02290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04760"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_014133641.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.6e-227,
                     bitscore: 753.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-13,
                     bitscore: 50.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.2e-33, bitscore:
                     113.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKKSHTAHQDAIFTATGPVLLRTPALPLPPRHRRAEPAASASPA
                     GSADSAHWGSPGGDPLGEQIGECFADRLVEAAADPVLREAIEISSPSLADLLERAVPAV
                     AAPEDGPRAAELHLAELRPAALRRAAEAVGRYRLRMATRATPFGLMAAVGTARFGARAE
                     VGWEGGERRAFRPDLGWLLPLLDRLRTDPQVLGSLLLAVDQQAVLRGDRLVLPYLPDRS
                     TLPESTAEAVPGAGRPVAERTVRATPVVRAVVRLAERPVSHAELLAGLAAGFPTAPAEA
                     IAGLVRTLVAQGFLLTDLVPPPHSTDLLGHVLERLPGEHPVRGELAAVRGLLARAAGLP
                     RGRATGVLREARRRMLRLGPAERPLHADLALVGGVVLPEQVRVEVEQAAGVLWRLSPPV
                     GAPEHLRSYHAEFVERYGIDSPVPLAELLDADTGLGPPAGYRRPVGPRGAANPEPARAR
                     TEREAARNRVLAELVAGALVDREPGGPLPEVVLDDELLDRLAPLAEESEEQESQAGSAA
                     ETPPASLELYAELAADSLAELDAGRFRLVLSPTAGSDRAGATFGRFASHLANSGSNSGS
                     GSGSGGSDPDSYGNDSYGDDNSNGGGRLLAEAAGALPDDDEVLYAHLEFTPYRPRHANI
                     ALTPRWLGHRVVVSAFPDPSGPAVLALDDLVVVADAERLGVYSRELGREVRADAHHALN
                     LRTGAPNAARFLQETALGGHRPWQPWDWGAAASSPVLPRVRRGRVVLAPASWRLTAPVP
                     DSAAPYGDWADGLARWRRRWGVPAAVRLLSGDQRISLDLDDPWHRRLLYGQCRADRPTV
                     LQEDLGAGSSGGWLPGPDGAHAAEIVVPLRPAGTGPTAKATAAKATTAQASAQATARTG
                     VPARRVLPAPHPRTVELPGGEWLFARIGAVETRHDEILADRLPELLARVPGQVDRWFFV
                     RYRDPAPHLRLRFHGEPSALTGELLPALHDWAHGLRRSGLAADLRLEGYAPEADRYGGP
                     EVLADAERVFHADSLVALAALRLVRTARGTPGELLAAANLTATARDFLAARPVPVPVGP
                     WVAATYPKSEAHQRIFRTQRAAALRAIGPDGPAAPAGGLLPADAALAGAWRLRAERLAA
                     YAPRLAGPVAGPALASLLHMGHNRLIGIDREAERRAYALARGALEAHRARHRTTTTTTT
                     TAPAPTAPAPVTPDEER"
     aSDomain        10613..10906
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KSE_RS02290_Lanthipeptide_LanB_RRE.1"
                     /evalue="5.50E-16"
                     /identifier="RREFam001.1"
                     /label="KSE_RS02290"
                     /locus_tag="KSE_RS02290"
                     /protein_end="302"
                     /protein_start="204"
                     /score="50.0"
                     /tool="antismash"
                     /translation="QAVLRGDRLVLPYLPDRSTLPESTAEAVPGAGRPVAERTVRATPV
                     VRAVVRLAERPVSHAELLAGLAAGFPTAPAEAIAGLVRTLVAQGFLLTDLVPP"
     gene            13549..14784
                     /locus_tag="KSE_RS02295"
                     /old_locus_tag="KSE_04770"
     CDS             13549..14784
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="KSE_RS02295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04770"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_014133642.1"
                     /sec_met_domain="LANC_like (E-value: 6.7e-40, bitscore:
                     135.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTEALQAVTARLSRPDATATTADSAGLGTGRSGAALALAVLAG
                     PDQEVRRAAHGHLAAAVRAPGAMRGGGLYSGAAAVLFAARVMARGPGEYRGLVDTLTPR
                     VAESAAGRAAALRADLAAGAGLRAHTFDAVSGAAGLGRLLLELAPDGPGTAEVLSALVE
                     LAAPTDGPLPRWWTAAAPDPEPVPAPEPVPAPGPGGGPTRSRGHLNFGLAHGIPGPLAL
                     LSLAGARNVRVPGQDEAVEALADRLIAHQLPSGGWPLTLSIEQAERRAVPADPPVRAAW
                     CYGTPGAARALFLAGRALGRADWQQAAVAALDNALADSGSWNLNGPGLCHGTGGLLRIV
                     QRMAADSGSAALAARLPALATATARDLTAALAADAPATLLEGTAGAALALHGHLNSPAG
                     EGTDWDACLLLS"
     gene            complement(15112..15900)
                     /locus_tag="KSE_RS02300"
                     /old_locus_tag="KSE_04780"
     CDS             complement(15112..15900)
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006604566.1"
                     /locus_tag="KSE_RS02300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04780"
                     /product="PP2C family serine/threonine-protein phosphatase"
                     /protein_id="WP_033260225.1"
                     /transl_table=11
                     /translation="MPYVVVSALSHDGVVRDHNEDSLVLGPWTLCATSTDSPQSLVFPY
                     GETPVVVAVADGLGGHPAGDVASALTVRHLAAAGPHLRGEQDVTDELHACHAALREASE
                     ADPALAGMATTVAGAVFADGHVTVFNVGDSQVYAITPDRGDGVGLRLLSTDDSPPPAPG
                     RRTSHLITQTVGGATAPEDFRPHLVRLPAEPGARYLLCTDGLTDPVAPEELAALLTEAD
                     AEADGDAQGDDQRALVDLWRAAIRAGGPDNVTLALVRIEE"
     misc_feature    complement(15854..15869)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            complement(16021..16194)
                     /locus_tag="KSE_RS02305"
                     /old_locus_tag="KSE_04790"
     CDS             complement(16021..16194)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133644.1"
                     /locus_tag="KSE_RS02305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04790"
                     /product="CsbD family protein"
                     /protein_id="WP_014133644.1"
                     /transl_table=11
                     /translation="MSTGDKIQNAAEKAKGAAKEAAGKAVGNERMEAEGKAEQAKGDLK
                     QAGEKAKDAFKH"
     gene            complement(16285..16713)
                     /locus_tag="KSE_RS02310"
                     /old_locus_tag="KSE_04800"
     CDS             complement(16285..16713)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.5"
                     /locus_tag="KSE_RS02310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04800"
                     /product="ATP-binding protein"
                     /protein_id="WP_014133645.1"
                     /transl_table=11
                     /translation="MPHHDARPPLPEAAVPGGQPPPSVRTAGQARAALTRLLEAAGHPG
                     GRVLADAHLAVTELVANAVHHGGGLTGFVARIGPGGTRLVVEVEDADDRHPVAQPLHDR
                     DPAAAGGRGWAIVQALTDSCHVEALPVGGKRIRVTFAL"
     gene            complement(16875..17237)
                     /locus_tag="KSE_RS02315"
                     /old_locus_tag="KSE_04810"
     CDS             complement(16875..17237)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.5"
                     /locus_tag="KSE_RS02315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04810"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_157850108.1"
                     /transl_table=11
                     /translation="MTDHTPGTPEPTVLHLRGDLDHDNEREVAAEVEAAAARSAGLLVL
                     DVSAVTFADSSALRTLVLAQQRAEEAGGALVLLGPLGPALRRLLEITATDGYFTVADTL
                     PQARAAAGAARRPDSA"
     gene            17491..21234
                     /locus_tag="KSE_RS02320"
                     /old_locus_tag="KSE_04820"
     CDS             17491..21234
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133647.1"
                     /locus_tag="KSE_RS02320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KSE_04820"
                     /product="SpoIIE family protein phosphatase"
                     /protein_id="WP_014133647.1"
                     /transl_table=11
                     /translation="MFGADPVVGADLARVDWAATPLGDPARWPQSLRSAVDTMLSSRFS
                     MWMAWGPELTFLCNGAYRRDTLGGKYPWALGRPFREVWAEVWADARPRIEHVLTEGEAT
                     WDEALLLYLERSGYPEETYHTFSYSPLRDEADEVAGVLCVVSEDTQRVVAERRLATLRD
                     LGSDPGAVRTEDEFLAFGAGQLARNPHDLPFTLVYLFDERGGARLAAASGVPDGHPAAP
                     ALIGPGQEGPWPVAAVRGGAPASVALPARGAFADLPRGAWEVPPRQARVVPLNGPDGGG
                     PSGFLVVGLNPHRPPDDGCLDFVGLVADRLAAGVASARGHEAQRRRAEQLAELDRAKTV
                     FFSNISHELRTPLTLIAGPAEDLRRRLADADPDVREDAETIHRNALRLGRLVDTLLDFS
                     RIEAGRMRARPRPVDLAAVTAELAAVFRPAVQRAGLTLEIDCPPLSAPVAVDPGLWEKV
                     VFNLLGNALKFTPEGTVRVRVRERDGRALVSVEDTGIGVPAAELPRLFDRFHRVEDARA
                     RSHEGSGIGLALAKELVELHDGTITAASTAGSGTTFTVDLPLAVGHSPAPAERPAAEAE
                     AFLQEALRWDVLPDEPGTEPATAPATDPAPGTAAHVLVVDDNADMRDYLARVLRGAGHR
                     VTAVGDGGRALAVLRAAPPGSPPGSGAGSPPELVISDVMMPGVDGLQLVAALRADPRTA
                     ALPVLLLSARAGRDDAVDGFESGADDYLVKPFATADLLVRVRAALRLARLRERHSRWQE
                     ALVDSLQDAFFVCDEDGAVVRVNAAFGAVLGYGPEGVPYPVPHPWWPDPAADPEGRRRA
                     TEALAGAQESGRGSATVPAVHRDGHRVWTHSTFNRVTDPATGRAVTVGTFRDVTTEYYA
                     VQRESAMAALTDCLARAAGAEEALAGALAELRGLWRADRVLAVRFDRGGGRPRLVAAGP
                     GPDWAGLPEEQRAALAALADAPALTPVPGPSWTGVRLEHPDGPLALAVELGGHRPFTRE
                     DELLLALLGGRLAQGLGRAHRIDQQRETAIALQHAILGPARLPEGFAARYEPATPPLEV
                     GGDWYDTVPLPDGRIGVIVGDCVGRGLAAAGVMGQLRSACRALLLQDHSPSRTLSALDA
                     FAAALPGAVCSTVFCGVLDPASGELRYSSAGHPPGVLVLADGGTELLEGGRALPLAVRI
                     GRPRPEAAAVLPGGSTLLLYTDGLVERRREGLAEGIARAGRAVVSGAGLPTAELPDHVT
                     ARLAPAGGYEDDVAVLLYRRPA"
     misc_feature    complement(22070..22084)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    complement(23759..23773)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.18"
                     /tool="antismash"
ORIGIN
        1 gcggccagcc cgtccggcac cgcgacgggg gtgaggtcgg aggtggggaa gtccatggtg
       61 accgcgccgt cgggcccggt ctcggcggtc aggatcccgc agcgggcggt gaaccggacc
      121 gggccggtgg ccgtgccggt ggtgtgcagg acgtgcgcgg tggccagggt ggcgtggccg
      181 cacatgtcca cctcggtgac gggcgtgaac cagcgcagcg cccagtccgc gtccccgccg
      241 ggcggcagcg ggtgggcgaa ggccgtctcg gagaggttga cctcggcggc cacccgctgc
      301 agccagtcgt ccgccgggaa gccggcggag tccagcagca cgaccgcggc cgggttgccg
      361 ccgaacgggc ggtcggtgaa ggcgtcgacg attcgaatcc gcatgccccg gaaggtacgg
      421 cagcgacggc ccggcggcca aggactgaca cctgcgcccg ggcgctgccc aggccaccgc
      481 cgcgtccggg gcaccgacgc gtccgggacg gcgccgcgct cagagcacct tcgccgcgaa
      541 ggccagcatc gcggggacgt ggtgcgcgcc gccgccctcg tggccgttgt acgggtagac
      601 cgcgatctcc ttcgggccgc ggtagtggtg gtaggaggcg aagacggtct ccggcgggca
      661 cacctcgtcc atcagcgcga ccgagtacag cgccggggcg gtggcgcggg ccgcgaagtg
      721 caggccgtcg acgtaggcga gggtggcgaa gacggtctcc accttgtcgc ggtggacctt
      781 gcagaagtcg gcgacctcct tgtacgggaa ggcgtcggtg atctcggtgg cgcgccggat
      841 gtgctggagg aacggcacct cagcgaccac cccggccagg tccggcacca ggcccgcgac
      901 ggccagggcc agcccgccgc cctggctgct gcccgccacc agcacccgtt ccgggtcgat
      961 cccggggtgg gtgcggacgg cgtccacggc gcgcaccgcg tcggtgtaga gccgccggta
     1021 gtagtaggcg gccgggtcga gcacgccccg ggtcatcgag ccggggtggg ccgggcccgc
     1081 gctgggcgcc tcgtcggagg tgtcgccgac cgcccacccg ccgccctgcc cccgggtgtc
     1141 catcaccagg tgcgcgtacc ccgcgctcgc ccacagcagg tgctcgtgcg ccaggccccg
     1201 gccgccgccg tacccgacgt agctcaccac cgccggcagc ggccccccgg ccccgcgcgg
     1261 acgcaccagc cagcccttga tcggctgccc cgcgtacccg gggaaggtga cgtcctcgac
     1321 cgtgacggtg gccagtccgg tctcgaccgc gacggtgtcc agccgggcgg ggacggccct
     1381 ggcctcggcc agggtgcccg cccagaaggc ggcgaagtcg tcgggttcgg tccgggccgg
     1441 ccggtgttcg cgcagctcgg acaggttcat cgagaggaag gccatgaccg gcgaggatag
     1501 gcgcggggcg cggcccggcc aatgccgggt ggcaccccgc gccggaaaac cgggccgtgg
     1561 cggggccgtc gccgtgaaag ttacatcggg cccggccccg ctcctccgat ccccgcccgc
     1621 ttcccgctgc ccggcccgac cgggtccggt ccggccgggg cgccggccgg gtcagcggca
     1681 gagcgccgcg tcgaccgcgt cggtcacgtg ctcggcggcg ggcggctccg ggacggtggt
     1741 gacggtgatg ttcgcggccc ggccgtcctc cgtgacgccg ccccggctcc ggtggcccgg
     1801 ggcggtgccg ccgtggcccc agaccagtcc gccgcagctc agcggcctgc tctggatccc
     1861 gaggccgtag cggacgccgg ggccgagcag ctcggcgggc acggtgctgc gcatctgggc
     1921 gagctgggcg gcgggcagca gtcggccgcc gagcagcgcg ccgtagaacg cgttgaggtc
     1981 gctgttggtc gacaccacgg cgcccgcggc ccaggccatc gacgagtcca tctcggtgta
     2041 gtcgaccagc cgcgctcccg aggcgggttc gccggtgtcg ccggtgttca ggtagccgtg
     2101 cgggtggggc tcgcggaggg cggtctcccc ggtggcgggg aggtaggtgt ggcgcaggcc
     2161 gatccggtcg atgacccgcc tggtgacctc ctcggcgtag gggcggccgg tcaccttctg
     2221 gatcagcagg ccggcgacca ggtagttggt gttgctgtac ccccagccgg tgccgggggc
     2281 gaacaccgcc cgctgggcca gtgccccgtc gaggagttcg cgcggctcga agtaccggta
     2341 ctggatggtg gtgaagtcga gcagcgccgg ggcgagcatg tagtcgggca ggccgctggt
     2401 gtgctggagc agttgacgga ccgtgatgtt ccggccgtcg acgccgtcgc cgcgcagcag
     2461 gccgggcagg taggtgtcga cgctggcgtc caggccgacc cggccctccg cgaccagttg
     2521 caggaccacg acggcggtga acgccttggt gttgctgccg gcccggatct gcccgtcgac
     2581 cgggaccccg gccccggtcg ccaggtcgcc gacgccggcg gtgtaggtgc ggctgcggcc
     2641 gtcccgcccc ttgacggtgg cgagggcggc gggcatcccg tccgccttca ccagcgcgtc
     2701 gaggcgctgc tgcacgacgt ccgggcgcgg tgcggcggcg ggcgcggctg aggctgaggc
     2761 tgaggctgag gctgaggtcg ggacgagggc ggtcagcgcg agtccggcgg cggccgtggc
     2821 cgtcatcgcg tgccggaccg cgcggatgcg gcgcgccgtg cggcgcgggg ggtgttcgtt
     2881 catcggggct ccttcttcgc tcttcgctgg cggggggtgg tgcgagccgg tgcggccggt
     2941 cagccgcaga gcgcctcgtc cacggcctgg tccgcgtgct tgccgacctc ctcgccggcc
     3001 gggaacccgg tcacggcgat gctcgcggcg cggccgtcgt cggtggtgcc gccgaaggtc
     3061 tcgtagccgg ggagcgcccc gccgtgcccc caggcgaccc cgccgcagga gagcgggcgg
     3121 ctgatcaggc cgaggccgta gcggacgccg gggccgagca gttcggcggg cacggtgctg
     3181 cgcatctggg cgagctgggc ggcgggcagc agtcggccgc cgagcagcgc gccgtagaag
     3241 gcgttgaggt cgctgttggt ggacaccatc gcgccggccg cccagcccca ggacgggtcg
     3301 agcttcgtgt agtcgcgcag cgatccgtcg gcggcccgca ggtagccctt ggggtgcgcc
     3361 tcgcggatcg tcgtctcgcc gggggcgggg aagtaggtgt ggcgcaggcc gatccggtcg
     3421 acgacccgct tggtgatctc ctcgccgagc gggcggccgg tcaccttctg gatgatcagg
     3481 ccggcgacca ggtagttggt gttgttgtac tcccaccggg cgccgggcgc gaagtgggcc
     3541 ttccgggcca gcgcggcgtc gaggagttcg cgcggctcga agtaccgtcc ggggtcggcg
     3601 agcacgccct cggtgtccac gtactcgggc aggccgctgg tgtgctggag cagttgacgg
     3661 accgtgatgt tccggccgtc gacgccgtcg ccgcgcagca ggccgggcag gtaggtgtcg
     3721 acgctcgcgt ccaggccgac ccggccctcc gcgaccagct ggaggaccac gacggcggtg
     3781 aacgccttgg tgttgctgcc gatccgcacc tgcccgtcca ccgggacctt ggcgccggtc
     3841 accgcgtcgc cgacgccggc cgtgtaggtg cggctgcggc cgtcccgccc cttgacggtg
     3901 gcgagggcgc cgggcacccc gtccgccttc accagcgcgt cgaggcgctg ccgggtcgcg
     3961 tccggccggg gcgcggccga ggccgagccc ggcgccagga ctccggccac cacggcggcg
     4021 gccagcgcgg ccacggtcac cgcggtgacg ccccggccgg cctcccggcc ggggcgtcgg
     4081 ccggtgcgcc gatcggtgcg tcggccggtg ggccgatcgg tttgccggtc ctcgcggagg
     4141 cggtgggcgc ggtgcgggcg cagtgcgttc tcgttcacgg ggaaaccctt ctggggaggg
     4201 cgccggagct cttcgcggcg ccctccaaga ggaccatccg acggaccgtc aatccgtccg
     4261 cgccgaggac gagaaggcac ccgggaaccc gctccggggc gacccccgtc ccgggaccct
     4321 gctcccggga cgacgagccc cgccggcacc gtgtaccgag cagcgcgacc ggtcgtcggg
     4381 cggtcgcgac atggagcaga atgtgcggca ccgcccccgg ggtgtgggcg gcaggccatc
     4441 ggcggggcgg gagtacctga gcacatgagc acggacatcg acgggcacgg ggtcacgccc
     4501 gcccgcccac cgggcgttgc ggaccgcccc gcaccgcacc tccgggtccc ggacgtgacc
     4561 cccgccccac cgacgggcgg tcccaacccg cccccgcgcc cgccctggtg ggaagagaac
     4621 gtcggggcgg gccgctgggc cggtgtcgag gccgacctgc tggcgctgcc gcgctcccgg
     4681 cgggccgacc gctcgccgac cccgctgcag atcctcggcg cgcggcggcg ggagagcagc
     4741 cacgagcact acctggcgtt cctcctcgat ccgcgggagg accacggctt gggcgcgggc
     4801 ctgctggccg ccctgctgga actggcgggc cgccccgatc tggccgccga cccgcgcctc
     4861 gaccgcaccc ggctgcaccg gcaggtctcc ggcgacgcca gccggccgga cctggtcgcc
     4921 accggccccg cagcttcggt ggtcgtcgag ttgaagatcg acgccccgga aggccaccgg
     4981 cagacgaccc gtcaggcgga cgacttcgcc ggtctggcgc agtcggccgt gttcgtctac
     5041 ctcaccccgg acggcaccgc accgggcgac gggcgcttcc gccccgtcgc acagcgcgac
     5101 ttggccggac gcctggcccg gctgctcgcc cggaccagca cggggcccga cgccgcagga
     5161 cccgacggcg caggaccggg cgccgcgggg cgccgacatg ccgaggacta cctgaacgac
     5221 ctggaggccg tggtgggcat cagcaccgac gacgacgagg acgcccgttt ctgggccacc
     5281 caccgcaccg cgctgctggc cgcgcaggcc gcgacccggc ggctgctgac gcgccttccg
     5341 gcacacaccg gcgtcgcgct ggccgccctc gccgacggcc tcggggcgga cctcgtcgtc
     5401 ggacacgtcg actacacgac gtccggcggc cacgcggaga gcgccgtcgt cctcagccgc
     5461 cccggctggc tggccgacgg cgtcccgcag ctcggcttcg gcctcgggat ccgccgcagg
     5521 agcggcggca cccagggccc cgacctggac ggggcggccc agcacccgtt ccacggcatc
     5581 tactgcaccc acccggcagt gcgcgcggaa ctcggacgcc gcctcgccca ccggggctgg
     5641 ggagggcact gggcctggtg gcagtacgcg gagttgactc cgcaaccggc gggcaccggc
     5701 ttcctcgacc acaacgcggc gaacgtcggt gccgcggtcc gcgacagctg gcttgatcac
     5761 atcgccgcgg tcgacgcgct gtgggccgcg cgccacaccc tctgagcacg cacttcaccg
     5821 ttcgaggcgc tgcggcggca ggccggtggc ggaggtgccc gggccgacgg cggggacgtc
     5881 ggcggcgcgg tgccgcggtc cacgcgctgg gcaccgacgg cccgatccac gagaacgacc
     5941 agcgcgctcc gggcacgggc aaccggtccg gctggaccct cgcgctcggc acccgtcggt
     6001 ggggctcgtc cggttctgac cgggacgggc cgtgggaccg gcacggtcat ggaccgtgcc
     6061 ggtccgggtc ggacggacgt cgtcccggcc ggtgaggcgg tgaggcggta aggcggcgag
     6121 gcgcgcggcc ccgccgggac cgaagcggcc cgccgcctcg ccggcggccc ccggaacggg
     6181 tgacgcccgg tcacccggtg cctcctcagt cgacgcggcg ccagttgatc caggagccgt
     6241 tgtcgttgcg ggtgatctcg tacaggtggc cgtcggacca gcgggcgctg aagtccaggc
     6301 tgccggagcc gtcggcgtac agccggatct cgctcgtgag gctgcccccg aacgagaccc
     6361 agtcgctggg gacgccggac gggctgatcc accgcgccca catggcattg tcggtcccga
     6421 ccgcgaagac gtggtcgacg ccgttgatgg tgcagtagag cgggtcgccc agggcaccgc
     6481 cgcacttgac cgggccgccg gccacgtcga gggacctcac ctcgatcttg gtggtgctgc
     6541 agtggacacg ggggaacttc gcggggacgg ccgcctgcgc cgtcgtggcg ccggcgaccg
     6601 cgccccccag cgccacgctc aggaatgcca tcgtgacggc ggcggtcctc ttgatcctca
     6661 acacccgggt ctcctcggtg gtggtggtcg agcgctactg gcccgttcga cgtgcccgcg
     6721 tccccacccg gttcggtccc gtccgccggg ccgcccgatc ctgccccatc gggcaaccgc
     6781 gcctacccgt acgaacgcgc gcaccgggaa tggtcgtcgc ggtcgaggcc cccgcgagga
     6841 ccgccccggg aaggcgccgc accgcgcggc agcgcaccga caccgacacc gacaccggcg
     6901 ccaccgccac cgccaccgcc accgccaccg accggaaccc gaacgcctga taccggcaaa
     6961 actgccgggg actcacctcc tcggacggcc ggtcggcagg acccgccagg ccggttccag
     7021 cggcagggcg ccgccgctca ccgaccggag gtcgtcctcg gggacggccc tggccctcag
     7081 ggccggcagg tgccggtcgg cgtagcggcg gtgggccgcc gggtcggacc acagggtcgc
     7141 gaccaggtgg cggtcctccc ccagccggac gacgaccccc gccagcatgc ccccggccgc
     7201 cgccatgccg ggcgcccaca cctcgcgctg gacgtcgagg aagtgcctcc cgcgaccggg
     7261 cgccagccga cagtccgcga cccgcagcag cgcggcccgc tccagcgcct gcggcaggcc
     7321 ggccgcgtcc cccggcatgt cgaggacgac ctcgccggcg gcggcgtcga tcgcggtgta
     7381 gccggccccg ctgccggccc ggccgtgccg ctcgtccgcg ctccgccgac tgtcggcggc
     7441 cacggcggcg tgccggtcgc gcatgaagcg caggtaggcg ccctcgtcag cccacaggcc
     7501 cagcagcagg gcgccgccgc cgtccgggtc ccagccgccg acctgcccga gcagtccggg
     7561 ctggtcgccg atcgccggcc aggcggcctg tgccgtggcg aaccgccccc gcgcggccac
     7621 cggcacccgg cacccgatcc acttgcccca catccgccgc ccgcctcccg atcgccaccg
     7681 gccgccaccc cgcccaccca tgatcgaccg ccgcccccga gcagcgtcaa tccgcccacg
     7741 gaccccaccg accgggacca ccgacgtacg accctctccc acggaagcgg aagccgaccg
     7801 gcaccggcac cggtatcagt acgggtcgga acagcccctc cgacagccgc tcgactgccc
     7861 gtccccccgg ccctcccagc gtccgatgac cggtgaacgg cgggccaaag tggccggttt
     7921 ccgatctggc ggcgggtacc gtccaccggt tccccttggt catccgcccg ttccggaacg
     7981 ggcgccggcc gaccgccggc agccctccgg acggtcggcc acaccgccgg acgggacgcc
     8041 ccgcaccggg caagccgagg agagggagcg agcggacgat ggaacggacc acggggcagc
     8101 agccgacgcg gaggcaggaa ccggggccgg ggcggggagc ggggccgggg cggggagcgg
     8161 ggccggggcg gggagcgggg cagcctccga gccgcgtgct gaccgagctg acgggcgacg
     8221 ccgacgcgtt cgccaaggcc gtggcggagg gcatcccgca ggtgttccga cccaccgggc
     8281 ggcccgccgg actgcccggg gtcgaggagt tggagacggt actgaacggc ggcctgctgc
     8341 gcgtcccgta cgtggagatg gtgcgggacg gcgcggtcgt cgagcccgaa ctcttctgcg
     8401 ccacccgcac ggtggccggg cggcgcgaga gcggctgggc ggaccccgcc cggatctccg
     8461 ccctgctcgc cgagggcgcc accctgctgc tgccccaact cgaccagtgg cacgccgggg
     8521 tacgggccat ggccaccgac atcgccctcc acctgggccg tcgcaccgag gcgttctgct
     8581 tcaccacggg cgcgggccgc cgcggcctgg acgtgcaccg cgacgacgcg gacgtcctgg
     8641 tcgtccaact cgccggcgcg aaggactgga ccgtccacga gccccccgcc gacggccact
     8701 ggcgccccgg cctcgccccc gcccccggac cggtcgccct gcgcacggcc ctcacccccg
     8761 gcgagatcct ctacgtcccg cgcggcgccc cgcacacggc aacgggccac cggggcctgt
     8821 cggtccacct gtcgttcacc atccgggagg caaccaccgg acgcctgcac gccgccctcg
     8881 gcgaattcct gaccacaccc ggcctgccga ccggtgacct gcccgaacgc ccggacacga
     8941 gcgaggtact ggccacagcc gccgaggtac tgcgactcgg ccgcgagcgc ctggccgcgc
     9001 tgaccccgga ggagctgctg cagctcgccc gggggccgct gcccgccggg gcggcggctg
     9061 cgccgggtgc gacgagcctg gcaggggcgg ggctggcggg agcggggctg ctgggggttg
     9121 agtggggcat gcgggacacg gcataggtga cgcgtcacgc atgccgtgac atgcgtgacg
     9181 tggcaataca tgacgcgaca ttgatgacac gtcacgcatg acgggacatg tgtgacgtga
     9241 catcgatgcc tcatcacaca tgtcgcgaca tgcatgacac gtcacgggtg acgcgtcatc
     9301 aatgcagcgt cacccgtgtc gcgacacgga tgacgtgcga tccatgacgt gacaccgatg
     9361 acgcagcaac gtatgccgcg acatcgatga cgaggcatgc atgacgcgac acacgtgatg
     9421 gcgcatgcgt gtcacaacac gcatgacgcg acacgcacga cagggcgcgg cgccccggac
     9481 cgcccgaacg gcccgtggta ccgcgcccgt cgtagccgtg cagcagccga ctcagcgcac
     9541 cggaccgatg ggcccggtca cgccggtcag atacagaacg ggcgggtgca ggaaccctca
     9601 caggagaggc tcacggcggc ttcctcgtgc tcggggctct cggcggcaac gaggtcctgc
     9661 acgtcgaggt cgaacagctc ctgcatgtcg gtggccatgg gggcgtccct tcgtcggtgc
     9721 cgcgactggc cgcggcgggc tgctgcggac gctaggcatc ctgcgtatgc atcgacaagg
     9781 agtgcgcacg gatgaatgga caaattcagc caactcttga tgatcctccg tcaaccatgg
     9841 acagttcggg gacgtcggga tagaacggtc cggccggatc acccggcaca ccagcaccac
     9901 gactacgcag cacggcaccg ccgtaccgca gcacaggacc gcagcacagg accgcacggc
     9961 cggacgaaag cacggcagta ccaggcactc ggggagcacg gtggggaaga agtcgcacac
    10021 ggcacaccag gacgcgatct tcaccgccac cggccccgtt ctgctccgta ctcccgcgct
    10081 gcccctcccg ccacgccatc gccgcgccga acccgcagca tcagccagcc ccgccggctc
    10141 tgccgactct gcccactggg gaagcccggg aggcgatccg ctcggcgagc agatcggtga
    10201 gtgcttcgcc gaccggctcg tcgaggccgc cgccgatccg gtgctgcgcg aggcgatcga
    10261 gatctccagc ccttcgctgg ccgacctgct ggagcgggcc gtcccggccg tggcggctcc
    10321 cgaggacgga cctcgcgccg ccgaactcca tctcgccgag ctccgccccg ccgcgctgcg
    10381 gcgggcggcc gaggcggtcg ggcggtaccg gttgcggatg gcgacccggg cgacgccctt
    10441 cgggttgatg gccgccgtcg ggacggcccg cttcggggct cgggccgagg ttggttggga
    10501 gggcggcgag cgccgcgcgt tccgtccgga cctgggctgg ttgctgccgt tgttggaccg
    10561 gctgcgcacc gatccgcagg tgctggggtc gctgctgctg gccgtggacc agcaggccgt
    10621 gctgcgcggg gaccgactcg tcctgccgta cctgcccgac cgctcgaccc tgccggagag
    10681 cacggcggag gccgttcccg gcgccggccg gccggtcgcc gagcggactg tccgcgcgac
    10741 gcccgtcgtg cgtgccgtcg tccggttggc cgaacggcct gtgtcgcacg ccgagttgct
    10801 ggcggggttg gccgccgggt tcccgaccgc gcccgccgag gcgatcgcgg ggctggtccg
    10861 cacgctggtc gcgcaggggt tcctgctcac cgacctggtg ccgccgccgc acagcaccga
    10921 cctgctgggg cacgtcctgg agcggctgcc cggcgagcac ccggtacgcg gcgaactggc
    10981 ggcggttcgc ggcctgttgg cgcgggcggc ggggttgccg cgggggcggg ccaccggtgt
    11041 gctgcgggag gctcggcggc ggatgctccg actcgggccc gccgagcggc cgttgcacgc
    11101 ggacctcgcg ctggtgggcg gggtggtgct gcccgagcag gtgcgggtcg aggtcgagca
    11161 ggccgccggt gtgctgtggc ggctctcccc gccggtcggc gcgcccgaac atctgcgctc
    11221 ctaccacgcg gagttcgtcg agcggtacgg catcgacagt cccgtcccac tggccgaact
    11281 gctcgacgcc gacaccggtc tcggcccgcc cgccggctac cgccgcccgg tcggcccgcg
    11341 cggcgcggcg aacccggagc ccgcccgtgc ccggaccgag cgggaggccg cccggaaccg
    11401 ggtgctggcc gaactggtcg cgggcgcact ggtcgaccgc gagcccggcg gtccgctgcc
    11461 ggaggtggtc ctcgacgacg aactgttgga ccgactggcc ccgttggcgg aggagagcga
    11521 ggaacaggag agtcaggcgg gcagcgccgc cgagactccg cccgcctcgc tggagctgta
    11581 cgccgagctc gccgccgact cgctcgccga gctggacgcc gggcggttcc gcctggtgct
    11641 ctcccccacc gccggcagcg accgggccgg agccaccttc ggccgcttcg cctcccacct
    11701 cgccaactcc ggctccaact ccggctccgg ctccggctcc ggcggctccg accccgacag
    11761 ctacggcaac gacagctacg gcgacgacaa cagcaacggc ggcggcaggc tgctcgccga
    11821 ggcagccgga gcactgcccg atgatgacga agtcctgtac gcgcacctgg agttcacccc
    11881 gtaccgcccc cggcacgcga acatcgcgct caccccgcgc tggctcggcc accgggtcgt
    11941 cgtcagcgcc tttcccgacc cgagcggccc ggccgtcctc gcgttggacg acctggtcgt
    12001 cgtggccgat gccgagcgcc tcggcgtgta ctcccgcgaa ctcggccggg aggtgcgggc
    12061 ggacgcgcac cacgcgctca acctccgtac gggtgcgccg aacgcggccc ggttcctgca
    12121 agaaacggcg ctcggcggcc accgcccctg gcagccctgg gactggggtg cggcggcgag
    12181 ttcccccgtg ctgccgaggg tccgccgggg gcgggtcgtc ctggcgcccg cgtcctggcg
    12241 gctgaccgct cctgtgcccg actcggcagc gccgtacggg gattgggccg acggcctggc
    12301 ccgctggcgt cggcggtggg gcgttcccgc cgccgtgcgg ctgctcagcg gggaccagcg
    12361 gatcagtctc gacctggacg atccgtggca ccgccgcctg ctgtacgggc agtgccgggc
    12421 cgaccggccc accgtcctgc aggaggacct gggcgccggt tcgtccggcg gctggctgcc
    12481 cggtccggac ggcgcgcacg ccgccgagat cgtcgtcccg ctgcgcccgg ccggcaccgg
    12541 ccccaccgcg aaggccaccg ccgcgaaagc caccaccgcg caggccagcg cgcaggccac
    12601 cgcgcggacc ggcgtaccgg cccgccgggt gctgcccgcg ccgcaccccc gtacggtcga
    12661 actcccgggc ggggaatggc tgttcgcccg gatcggggcc gtcgaaacga ggcacgacga
    12721 gatcctcgcc gaccggctgc ccgagctgct ggcccgggtt cccgggcagg tggaccgctg
    12781 gttcttcgtc cgctaccggg atccggcgcc gcacctgcgg ctgcgcttcc acggcgaacc
    12841 gtccgcgctg acaggcgagt tgctgcccgc gctgcacgac tgggcgcacg ggctgcgccg
    12901 gtccgggctg gccgccgacc tgcggctgga ggggtacgcg cccgaggccg accggtacgg
    12961 cggaccggag gtgctggccg acgcggagcg ggtcttccac gccgacagcc tggttgcgct
    13021 ggccgcgctg cggctggtcc ggacggcccg gggtacgccc ggtgagctgc tcgccgccgc
    13081 caacctgacc gccaccgccc gggacttcct ggccgcccgt cccgtcccgg tgccggtcgg
    13141 gccgtgggtc gccgcgacct atcccaagtc cgaggcgcac caacggattt tccgcaccca
    13201 gcgggccgcc gcactgcgcg ccatcggccc ggacggcccc gccgcgcccg ccggcggtct
    13261 gctacctgcc gacgccgccc tcgccggggc gtggcggctc cgcgccgagc ggctcgccgc
    13321 gtacgcgccc cggctcgccg gccccgtcgc ggggcccgcg ctcgcctcgc tcctgcacat
    13381 gggccacaac cggctgatcg gcatcgaccg ggaggccgag cgccgcgcct acgccctcgc
    13441 ccgcggcgcc ctcgaagccc accgggcccg ccatcgcacc acgaccacca ccaccaccac
    13501 cgcaccggcc cccaccgcac cggcccctgt caccccggac gaggagcgat gacgcccacc
    13561 gaagcgctgc aggcggtcac cgcccgactg tcccgccccg acgccaccgc gaccaccgcc
    13621 gacagcgccg gactcgggac cgggcgcagc ggcgcggcgc tcgccctcgc cgtgctggcg
    13681 gggccggacc aggaggtgcg ccgggccgcg cacgggcacc tcgcggcggc ggtgcgggcg
    13741 ccgggcgcga tgcggggcgg tgggctctac tcgggcgccg ccgcggtgct gttcgccgcc
    13801 cgggtgatgg cccgggggcc gggcgagtac cgaggtctgg tggacaccct gacgccccgg
    13861 gtcgcggagt ccgccgccgg acgggcggcc gcgctgcggg ccgacctggc ggcgggggcg
    13921 gggctgcggg cgcacacctt cgacgccgtc tcgggcgcgg ccggtctggg ccggctgctg
    13981 ctggagctgg cgccggacgg ccccggcacg gccgaggtgc tgtccgcgct ggtcgaactc
    14041 gccgccccga cggacggacc gctgccccgc tggtggaccg cggccgcccc cgaccccgag
    14101 cccgtgccgg ctcccgaacc cgtgccggcc cccgggcccg gaggtggccc gacacgctcc
    14161 cggggtcacc tcaacttcgg tctggcgcac gggattccgg gcccgctggc gctgctctcg
    14221 ctggccgggg cacggaatgt ccgggtgccc ggtcaggacg aggcggtcga ggcgctcgcg
    14281 gatcggctca tcgcccatca actgccttcc ggtggctggc cgttgacgct gagcatcgag
    14341 caggcggaac ggagagccgt accggccgac ccgccggtcc gggcggcctg gtgctacggc
    14401 acgcccggtg cggcgcgggc actgttcctg gccggacggg cgctgggccg cgccgactgg
    14461 cagcaggccg ccgtcgccgc actcgacaac gccctggcgg acagcggtag ttggaacctg
    14521 aacggcccgg gcctctgcca cggcaccggc ggcctgctgc ggatcgtcca gcggatggcc
    14581 gcggactccg gctccgccgc cctggccgcc cggctgcccg ccctcgccac ggcgaccgcc
    14641 cgggacctca ccgccgccct ggccgccgac gccccggcca ccctcctgga gggcaccgcc
    14701 ggcgcggccc tggcgctgca cggccacctc aactcccctg cgggggaagg gaccgactgg
    14761 gacgcctgcc tgctcctgag ctgagtccgc cgacgccccg gggccgccac cggcctctcc
    14821 tgtcctgccg gaaggcggaa acctcagggc ttcggtcccc cgggaagggc aggaactttc
    14881 gcggccgccg aagagcgcca cccttacgct tcccctcatc cgcagggtga ccgcgcgctc
    14941 caccggccac ctcccgcggc acagcgatca agtcgcttgc accacaggcg agtccacctt
    15001 ccctccggag ccggaacgcc gctcgaaccc ggggcgcgcg gtttcaaggc gtgcgggggc
    15061 cgggtcggcg ggcggcgcgg aagcggcccg ccggaacgcg cggctccccg gtcactcctc
    15121 gatccggacc agggcgaggg tgacgttgtc cgggccgccg gcccggatcg cggcccgcca
    15181 gaggtcgacc agggcgcgct ggtcgtcgcc ctgtgcgtcg ccgtcggcct cggcgtcggc
    15241 ctcggtgagc agggcggcca gttcctcggg ggcgaccggg tcggtgaggc cgtcggtgca
    15301 cagcaggtag cgggcgccgg gttcggcggg cagccggacg aggtgcggcc ggaagtcctc
    15361 cggggcggtg gcgccgccca ccgtctgggt gatcaggtgg ctggtgcgcc ggccgggggc
    15421 gggcggcggg ctgtcgtcgg tgctgagcag gcgcagtccg acgccgtcgc cgcggtccgg
    15481 ggtgatcgcg tagacctggc tgtcgccgac gttgaacacg gtgacgtgcc cgtccgcgaa
    15541 gaccgccccg gcgacggtgg tcgccatgcc ggccagtgcg gggtcggcct cggacgcctc
    15601 ccgcagggcg gcgtggcagg cgtgcagttc gtcggtgacg tcctgttcgc cgcgcaggtg
    15661 cggcccggcc gcggcgaggt ggcggaccgt gagcgcggag gcgacgtccc ccgccgggtg
    15721 cccgccgagg ccgtccgcga cggcgaccac caccggggtc tccccgtacg ggaagaccag
    15781 gctctgcggg ctgtcggtcg aggtggcgca cagcgtccac ggtccgagga cgaggctgtc
    15841 ctcgttgtgg tcgcggacca ctccgtcatg gctgagcgca ctgacgacga cgtacggcaa
    15901 cttccctgcc cttcaccgag cccccgtgcg agatctgtcg ccgccattct cctcaccccg
    15961 ccgcccgggc gtgtcgcggg gccccggcgg cgtaccgccg gggccccgcg ggggaggtgc
    16021 tcagtgcttg aaggcgtcct tggccttctc gccggcctgc ttgaggtcgc ccttggcctg
    16081 ctcggccttg ccctcggcct ccatccgctc gttgccgacc gccttgccgg cggcctcctt
    16141 cgcggcgccc ttggccttct cggcggcgtt ctggatcttg tcgcccgtgc tcatggtggc
    16201 ctcccgaccg tcggttccga cactgtcgac gtgccgtatg ccccggttcg ccggaaagat
    16261 gcacccgttt cgggggcgtt ctccctacag cgcgaaggtg acccggatgc gcttgccgcc
    16321 gacgggcagc gcttcgacgt ggcagctgtc ggtgagggcc tggacgatgg cccagccgcg
    16381 gccgccggcg gcggccgggt cgcggtcgtg caggggttgg gcgaccgggt ggcggtcgtc
    16441 ggcgtcctcg acctcgacga ccagcctggt cccgccgggg ccgatccggg cgacgaagcc
    16501 ggtcaggccg ccgccgtggt gcacggcgtt ggcgacgagc tcggtcaccg cgaggtgcgc
    16561 gtcggcgagc acccggccgc cggggtgccc ggcggcctcc agcagccggg tgagggcggc
    16621 gcgggcctgg cccgccgtcc gcacggacgg gggcggctgc cctcccggga cggcggcctc
    16681 cgggagcggc ggccgtgcgt cgtggtgggg catgaacgac ctcgaatcgt cttcggcacc
    16741 gggtgtgccg gctggcgagg ccggacgtgc ggcgggatcg ggtgacgtgt gccccgaggg
    16801 ggccggatga tgcggccggg acggcgcgcg gtgggacgga accggagtgg cgacggaacc
    16861 ggagtggcgc gcggtcaggc ggaatcgggg cggcgcgcgg ctccggcggc ggcccgggcc
    16921 tgcgggaggg tgtcggcgac ggtgaagtac ccgtcggtgg cggtgatctc cagcaggcgc
    16981 cggagcgcgg gcccgagcgg tccgagcagg accagggcgc cgccggcctc ctccgcgcgc
    17041 tgctgggcca gtaccagggt ccgcagggcg gaggagtcgg cgaaggtgac cgccgagacg
    17101 tcgaggacga ggaggccggc gctgcgggcg gcggcggcct ccacctcggc ggcgacttcg
    17161 cgctcgttgt cgtggtcgag gtctccgcgc aggtgcagca ccgtcggctc gggtgtcccc
    17221 ggggtgtggt cggtcatggc ggccatggta agccgcgtcc ggcggctccc ggtcggcccg
    17281 ggtccccgtg gtcctcccgg gcggggagcc gacggggagc gggcgggggg cgggcggccg
    17341 ccgggagggt cgggcgggtt gcccgggcgg ggagcgggca gccgcaggag ccggggcgcg
    17401 tacccggcac aatggacggc ggtaccgcgg tgggcggggc cgaggtcggg cggagggagg
    17461 gacccgttgg cgcgggagcg gtcgcgggag gtgttcggcg ccgatccggt ggtgggcgcc
    17521 gacctggcgc gggtggactg ggcggcgacg ccgctgggcg acccggcgcg ctggccgcag
    17581 agcctgcgtt cggcggtgga cacgatgctg tcctcgcggt tctcgatgtg gatggcctgg
    17641 ggcccggagc tgacgttcct ctgcaacggc gcgtaccggc gcgacacact gggcggcaag
    17701 tacccgtggg cgctgggccg cccgttccgg gaggtgtggg cggaggtctg ggcggacgcc
    17761 cggccgcgga tcgagcacgt gctgaccgag ggcgaggcga cctgggacga ggcgctgctg
    17821 ctgtacctgg agcggtccgg ctaccccgag gagacctacc acaccttctc ctacagcccg
    17881 ttgcgcgacg aggcggacga ggtggcgggc gtgctgtgcg tggtcagcga ggacacccag
    17941 cgggtcgtcg cggagcgccg gctggcgacg ctgcgcgacc tggggtccga cccgggggcg
    18001 gtgcgcaccg aggacgagtt cctggcgttc ggcgccgggc agctcgcccg caacccgcac
    18061 gacctgccct tcaccctggt ctacctgttc gacgagcggg gcggcgcccg gctggccgcg
    18121 gcctccggcg tgccggacgg gcacccggcc gcgcccgcgc tgatcgggcc cggccaggag
    18181 gggccgtggc cggtcgcggc ggtccgcggc ggcgcgcccg cctccgtggc gctgccggcc
    18241 cggggcgcgt tcgccgacct gccgcgcggg gcctgggagg tgccgccccg gcaggcccgg
    18301 gtggtgccgc tgaacggtcc ggacggcggc gggccgagcg ggttcctggt cgtcggcctc
    18361 aacccgcacc gcccgccgga cgacggctgc ctcgacttcg tcggcctggt cgcggaccgg
    18421 ctggcggcgg gggtcgccag cgcccgcggg cacgaggcac agcggcggcg ggcggagcag
    18481 ctggccgagc tggaccgggc gaagaccgtg ttcttctcga acatcagcca cgagctgcgc
    18541 accccgctga cgctgatcgc cggcccggcc gaggacctgc ggcgacggct cgcggacgcc
    18601 gacccggacg tccgggagga cgcggagacc atccaccgca acgcgctgcg gctgggccgg
    18661 ctggtggaca ccctgctgga cttctcccgg atcgaggcgg gccggatgcg ggcccggccc
    18721 cggccggtgg acctggcggc ggtcaccgcc gagctggcgg ccgtgttccg tccggcggtc
    18781 cagcgggccg ggctgacctt ggagatcgac tgcccgccgc tgagcgcccc ggtcgcggtg
    18841 gacccggggc tgtgggagaa ggtggtcttc aacctgctgg gcaacgccct gaagttcacc
    18901 cccgagggga cggtgcgggt gcgggtgcgc gagcgggacg ggcgggccct ggtcagtgtc
    18961 gaggacaccg ggatcggggt cccggccgcg gagctgccgc gactgttcga ccgcttccac
    19021 cgggtcgagg acgcccgggc gcgctcgcac gagggcagcg ggatcggcct ggccctggcc
    19081 aaggaactcg tcgagctgca cgacgggacg atcaccgccg cctccaccgc gggcagcggc
    19141 accaccttca ccgtcgacct gccgctggcc gtcggccact cccccgcccc ggcggagcgc
    19201 ccggccgccg aggcggaggc gttcctccag gaggccctgc gctgggacgt cctcccggac
    19261 gagcccggca ccgagcccgc gacggcaccc gcgacggacc ccgcgcccgg cacggccgcg
    19321 cacgtcctgg tcgtcgacga caacgccgac atgcgcgact acctggcccg ggtcctgcgc
    19381 ggcgcgggcc accgggtcac cgcggtcggc gacggcggcc gggcgctggc cgtcctgcgc
    19441 gcggcaccgc ccgggtcgcc gcccgggtcg ggggcggggt cgccgcccga gctggtgatc
    19501 agcgacgtga tgatgcccgg cgtggacggc ctgcaactgg tcgcggcgct gcgcgccgat
    19561 ccgcgcacgg cggccctgcc ggtgctgctg ctctcggcgc gggccgggcg ggacgacgcc
    19621 gtggacggtt tcgagtcggg ggcggacgac tacctggtga agcccttcgc caccgccgac
    19681 ctgctggtcc gggtgcgcgc ggcgctgcgg ctggcgcggc tgcgcgagcg gcactcgcgc
    19741 tggcaggagg cgctggtgga ctcgctgcag gacgccttct tcgtctgcga cgaggacggc
    19801 gcggtggtcc gggtcaacgc ggcgttcggc gccgtgctgg gctacggccc ggagggggtg
    19861 ccctacccgg tgccgcaccc gtggtggccg gatccggcgg ccgacccgga gggccggcgg
    19921 cgggcgaccg aggcgctggc cggcgcgcag gagagcgggc gcggcagcgc caccgtgccg
    19981 gccgtgcacc gggacggcca ccgggtgtgg acgcactcga ccttcaaccg ggtgacggac
    20041 ccggcgaccg ggcgcgccgt cacggtgggc accttccggg acgtcacgac cgagtactac
    20101 gccgtccagc gggagagcgc catggcggcg ctgaccgact gcctggctcg ggcggccggg
    20161 gccgaggagg cgctggccgg cgcgctggcg gagctgcgcg ggctgtggcg ggccgaccgg
    20221 gtgctggcgg tgcgcttcga ccggggtggc ggtcgacccc ggctggtggc cgccggaccg
    20281 gggccggact gggcggggtt gccggaggag cagcgggcgg cgctggccgc gctggccgac
    20341 gcgccggcgc tcactcccgt cccggggccg tcgtggaccg gtgtccggct ggagcacccg
    20401 gacgggccgc tggccctggc ggtggagctg ggcgggcacc ggccgttcac ccgggaggac
    20461 gagctgctgc tggcgctgct gggcgggcgg ctcgcccagg ggctgggccg ggcgcaccgg
    20521 atcgaccagc agcgcgagac ggcgatcgcc ctccagcacg ccatcctggg gccggcccgg
    20581 ctgccggagg gtttcgcggc ccggtacgag ccggccaccc cgccgttgga ggtgggcggc
    20641 gactggtacg acaccgtgcc gctgccggac ggccggatcg gcgtcatcgt gggcgactgc
    20701 gtcgggcgcg ggctggccgc ggcgggggtg atggggcagt tgcgcagcgc ctgccgggcc
    20761 ctgctgctcc aggaccacag cccgtcccgg acgctgtccg cgctggacgc gttcgcggcg
    20821 gcgctgcccg gggcggtctg cagcacggtg ttctgcgggg tcctcgaccc cgcctccggt
    20881 gagctgcgct actccagcgc cgggcacccg ccgggcgtgc tggtcctggc ggacggcggc
    20941 acggagctgt tggagggcgg ccgcgccctg ccgctggccg tgcggatcgg tcggccgcgc
    21001 ccggaggcgg cggcggtcct gccgggcggc tcgacgctgc tgctgtacac ggacgggctg
    21061 gtggagcggc ggcgcgaagg gctggccgag ggcatcgcgc gggccgggcg cgcggtggtg
    21121 tcgggcgcgg gtctgccgac ggccgagctg ccggaccacg tgacggcccg gctggccccg
    21181 gccggcgggt acgaggacga cgtggccgtg ctgctctacc ggcggccggc ctgaccgccg
    21241 ccggcctggc cgccgaccct cgtgagcagg ggttttgccc ccgctcgcgg cggctggggt
    21301 agcctcgccc gaggcccggc ggcacccctg aacggctggt tcccggtggc ctgtgcgctt
    21361 tgttcggttg cccggccgca gggcggggtg tggcaggagg cggagctttc gatggctggc
    21421 tcgacgacgt cgcgggacgc gcggcaggga gcggtggccg atcggtcgac gatcggtgag
    21481 gccgagctcc gttcgctgtt ggcggggctg acggcggtgc gggacgggaa tttcagcacc
    21541 aagctggccg gtacctcgga cggtctgctg ggtgagatcg cgaccgtgtt caacggcatg
    21601 gtggaccagc tgtcgcggtt cacctccgag gtgacccggg tggcccgcga ggtcggcacc
    21661 gaggggcagt tgggcggcca ggccgtggtg ccgggggtgt ccggcacctg ggaggacctg
    21721 accgactcgg tcaacgcgat ggcgggcaac ctgaccaccc aggtccgcga catcgcgcag
    21781 gtcgccaccg cggtcgccaa gggcgacctg tcgcagaaga tcaccgtgga cgcccggggc
    21841 gagatcctgg agctgaagaa caccgtcaac acgatggtcg accagctgag ttcgttcgcc
    21901 ggcgaggtca cccgcgtcgc ccgcgaggtc ggcaccgagg gcatcctcgg cggccaggcg
    21961 gacgtgaagg gcgtctccgg gacgtggcgc gacctgaccg actcggtgaa ctcgatggcg
    22021 ggcaacctga ccggccaggt ccgggcgatc gcgcaggtcg ccaccgcggt ggccgagggc
    22081 gacctgtcgc agaagatcac cgtggacgcc cggggcgaga tcctggagct gaaggacacc
    22141 atcaacacga tggtcgacca gctgagttcg ttcgccggcg aggtcacccg cgtcgcccgc
    22201 gaggtcggta ccgagggccg gctcggcggc caggcggacg tccgcgacgt gtccggcacc
    22261 tggcgtgacc tgaccgagtc ggtgaacgtg atggccgaca acctgaccgc gcaggtccgg
    22321 gcgatcgcgc aggtcacgac ggcggtcgcc aagggcgacc tgacgcagaa gatccgggtg
    22381 gacgcccggg gcgagatcct ggagctgaag gagaccatca acacgatggt cgaccagctc
    22441 tccgcgttcg ccgacgaggt gacccgggtg gcccgcgagg tcggcacggc cggcaacctg
    22501 ggcgggcagg cgaccgtccg gggcgtctcc ggcacctgga aggacctgac cgacaacgtc
    22561 aacgtgatgg cgtccaacct gaccggccag gtccgctcga tcgcgcaggt cgccaccgcg
    22621 gtggcgcgcg gcgacctcag ccagaagatc accgtcgagg cggagggcga ggtcgccgcg
    22681 ctggccgggg tgatcaacac gatggtggac accctgtcgg cgttcgcgga cgaggtgacc
    22741 cgggtagccc gcgaggtcgg caccgagggc atcctcggcg gccaggcccg ggtgccgaac
    22801 gtcgcgggca cctggaagga cctgaccgac aacgtcaact tcatggcgca caacctgacc
    22861 tcgcaggtcc gcaacatcgc gcaggtcacc accgcggtcg ccaacggcga cctgacccgg
    22921 aagatcgacg tcgacgcgcg cggcgagatc ctggagctga agaccaccat caacacgatg
    22981 gtcgaccagc tgagctcgtt cgccgccgag gtgacccgcg tcgcccgcga ggtcggcagt
    23041 gagggccggc tcggcggcca ggccgaggtg gagggcgtct ccggcacctg gaagcgcctc
    23101 accgagaacg tcaacgagct cgccgggaac ctcacccggc aggtccgcgc gatcgccgag
    23161 gtgaccagcg cggtcgccgc gggcgacctg acccgctcga tcaccgtcga cgcgtccggc
    23221 gaggtcgccg acctcaagga caacatcaac gccatggtcg gctcgctgcg cgagaccacc
    23281 cgcgccaacg aggaacagga ctggctgaag accaacctgg cccgcttctc cggcctgctg
    23341 cagggccggc gcgacctggc cgtggtcgcc gaggcggtga tggacgagct caccccgctg
    23401 gtcggcgcgc aggtcggcgc gttctacctg gccgaggaga ccgacggcgg gacggtgctg
    23461 cggctgatcg gctcgtacgc gtacccggac ggcgggcggc ccaccagctt ccggctgggc
    23521 gagtcgttcg tcgggcaggc cgcgcgcagc cggcgcacca tcgccgcgga cgccctcccc
    23581 gcgggctacc tggcggcctc ctccggcctg ggccggaccg aggagctgtc gctgctggtc
    23641 gtcccgatcg tggtggagga ccaggtgctc ggcgtgatcg agctggcctc gatccggccg
    23701 tacccggccg tgcaccgggc cttcctggac cagctgatgg agaccgtcgg cgtcaacctg
    23761 aacacgatcg tcgccaacgc ccgcaccgac gagctgctgg gcgagtcgca gcggctgacc
    23821 tccgaactgc aggcccgctc gcaggagttg caggccaggc aggaggagct ccaggcgtcc
    23881 aacgcggaac tggaggagaa ggccgcgctg ctggccgccc agaaccggga catcgagacc
    23941 aagaacctgg agatcgagca ggcccggcag gagctggagg agcgggcgca ccagctctcg
    24001 ctggcctcga cctacaagtc ggagttcctg gcgaacatga gccacgagct gcgcaccccg
    24061 ctgaacagcc tgctgatcct ggcccagctg ctcgcccaga acccgacccg gaacctgacg
    24121 gccaagcagg tcgagtacgc gggcatcatc cactcggcgg gctcggacct gctccagctg
    24181 atcaacgaca tcctggacct gtcgaaggtc gaggccggga agatggacct cagcccggag
    24241 ccggtggcgc tgcgcagcct gctggactac gccgaggcca ccttcaagcc gctgaccggg
    24301 cagaagaacc tggccttcac cgtccgcacc tcgcccgacg tgccggagcg gctggtcacc
    24361 gacgactacc ggctgcgcca ggtgctgcgg aacctgctct ccaacgcggt gaagttcacc
    24421 gagcagggcc gggtcgagct gcggatcggc ctcgccccgc aggaccggat ccccgagggg
    24481 gtgcggcgcg gcgggccggt gctggccttc caggtctccg acaccggcat cggcatcgcg
    24541 ccgcagcacc tggagagcgt cttcggcgcg ttccagcagg ccgacggcac caccagccgc
    24601 aagtacggcg gcaccgggct cggcctgtcc atcagccggg agatcgccta cctgctgggc
    24661 ggggcgatca ccgccgagag cgtgctgggc gccggcagca ccttcacgct gttcctgccg
    24721 gtcagccgtc cggagttcct cgccctggag accgagccgc ggtccggcgc gccggagcgg
    24781 gggc
//
